                         SEQUENCE LISTING

<110>  Biokine Therapeutics Ltd.
       BIOLINERX LTD.
       PELED, Amnon
       ABRAHAM, Michal
 
<120>  METHODS OF TREATING ACUTE MYELOID LEUKEMIA WITH A FLT3 MUTATION

<130>  59549

<150>  US 61/897,921
<151>  2013-10-31

<150>  US 61/945,302
<151>  2014-02-27

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  1

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  2

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  3

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  4

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<400>  5

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' acetylated citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  6

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' acetylated citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  7

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<400>  8

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<400>  9

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  10

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  11

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATED

<400>  12

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  13

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  14

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (11)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  15

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Xaa Xaa Cys Arg 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  16

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  17

Arg Glu Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  18

Arg Arg Xaa Cys Tyr Glu Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  19

Arg Arg Xaa Cys Tyr Arg Glu Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  20

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  21

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Glu Xaa Cys Arg 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  22

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Glu 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' amidated

<400>  23

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  24

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  25

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  26

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  27

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Xaa Arg Xaa Cys Arg 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  28

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED D-glutamic acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  29

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  30

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Xaa Arg Xaa Cys Arg 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  31

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  32

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Guanyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  33

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Tetramethylguanyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  34

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  35
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Tetramethylguanyl-arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  35

Xaa Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  36
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  amidated

<400>  36

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  37

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  38
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-aminopentanoyl-arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  38

Xaa Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  39
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-desamino-arginyl

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  39

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Guanyl-arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  40

Xaa Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Succinyl-arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  41

Xaa Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Glutaryl-arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  42

Xaa Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  43
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  desaminoTMG-APA (formula IV in the specification)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  43

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R-CH2 - formula (V) in the specification

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  c' amidated

<400>  44

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  45
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  c' amidated

<400>  45

Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10              


<210>  46
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  tetramethylguanyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  46

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  6-aminohexanoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  47

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  6-aminohexanoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  48

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' amidated

<400>  49

Arg Arg Xaa Cys Tyr Xaa Arg Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' amidated

<400>  50

Arg Arg Xaa Cys Tyr Xaa Arg Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  51
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  51

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N' ACETYLATED

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  52

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  derivatization by a NH-methyl group

<400>  53

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  derivatization by a NH-ethyl group

<400>  54

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  derivatization by NH-isopropyl

<400>  55

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-fluorobenzoyl-arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  derivatization with a tyramine residue

<400>  56

Xaa Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  57

Ala Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  58

Arg Arg Xaa Cys Tyr Ala Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  59
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  59

Arg Arg Xaa Cys Tyr Arg Ala Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-alanine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  60

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  61

Arg Arg Xaa Cys Tyr Arg Lys Xaa Ala Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  62
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  62

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Ala Arg Xaa Cys Arg 
1               5                   10                  


<210>  63
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  63

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Ala Xaa Cys Arg 
1               5                   10                  


<210>  64
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  64

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  65
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  65

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  66

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  67
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  67

Arg Arg Xaa Cys Tyr Arg Xaa Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' AMIDATED

<400>  68

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  69
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  69

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  70
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  70

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  71
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<400>  71

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  72
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-((2-naphthyl) alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-citrulline

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  citrulline

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C' Amidated

<400>  72

Xaa Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  73
<211>  2982
<212>  DNA
<213>  Homo sapiens

<400>  73
atgccggcgt tggcgcgcga cggcggccag ctgccgctgc tcgttgtttt ttctgcaatg       60

atatttggga ctattacaaa tcaagatctg cctgtgatca agtgtgtttt aatcaatcat      120

aagaacaatg attcatcagt ggggaagtca tcatcatatc ccatggtatc agaatccccg      180

gaagacctcg ggtgtgcgtt gagaccccag agctcaggga cagtgtacga agctgccgct      240

gtggaagtgg atgtatctgc ttccatcaca ctgcaagtgc tggtcgacgc cccagggaac      300

atttcctgtc tctgggtctt taagcacagc tccctgaatt gccagccaca ttttgattta      360

caaaacagag gagttgtttc catggtcatt ttgaaaatga cagaaaccca agctggagaa      420

tacctacttt ttattcagag tgaagctacc aattacacaa tattgtttac agtgagtata      480

agaaataccc tgctttacac attaagaaga ccttacttta gaaaaatgga aaaccaggac      540

gccctggtct gcatatctga gagcgttcca gagccgatcg tggaatgggt gctttgcgat      600

tcacaggggg aaagctgtaa agaagaaagt ccagctgttg ttaaaaagga ggaaaaagtg      660

cttcatgaat tatttgggac ggacataagg tgctgtgcca gaaatgaact gggcagggaa      720

tgcaccaggc tgttcacaat agatctaaat caaactcctc agaccacatt gccacaatta      780

tttcttaaag taggggaacc cttatggata aggtgcaaag ctgttcatgt gaaccatgga      840

ttcgggctca cctgggaatt agaaaacaaa gcactcgagg agggcaacta ctttgagatg      900

agtacctatt caacaaacag aactatgata cggattctgt ttgcttttgt atcatcagtg      960

gcaagaaacg acaccggata ctacacttgt tcctcttcaa agcatcccag tcaatcagct     1020

ttggttacca tcgtagaaaa gggatttata aatgctacca attcaagtga agattatgaa     1080

attgaccaat atgaagagtt ttgtttttct gtcaggttta aagcctaccc acaaatcaga     1140

tgtacgtgga ccttctctcg aaaatcattt ccttgtgagc aaaagggtct tgataacgga     1200

tacagcatat ccaagttttg caatcataag caccagccag gagaatatat attccatgca     1260

gaaaatgatg atgcccaatt taccaaaatg ttcacgctga atataagaag gaaacctcaa     1320

gtgctcgcag aagcatcggc aagtcaggcg tcctgtttct cggatggata cccattacca     1380

tcttggacct ggaagaagtg ttcagacaag tctcccaact gcacagaaga gatcacagaa     1440

ggagtctgga atagaaaggc taacagaaaa gtgtttggac agtgggtgtc gagcagtact     1500

ctaaacatga gtgaagccat aaaagggttc ctggtcaagt gctgtgcata caattccctt     1560

ggcacatctt gtgagacgat ccttttaaac tctccaggcc ccttcccttt catccaagac     1620

aacatctcat tctatgcaac aattggtgtt tgtctcctct tcattgtcgt tttaaccctg     1680

ctaatttgtc acaagtacaa aaagcaattt aggtatgaaa gccagctaca gatggtacag     1740

gtgaccggct cctcagataa tgagtacttc tacgttgatt tcagagaata tgaatatgat     1800

ctcaaatggg agtttccaag agaaaattta gagtttggga aggtactagg atcaggtgct     1860

tttggaaaag tgatgaacgc aacagcttat ggaattagca aaacaggagt ctcaatccag     1920

gttgccgtca aaatgctgaa agaaaaagca gacagctctg aaagagaggc actcatgtca     1980

gaactcaaga tgatgaccca gctgggaagc cacgagaata ttgtgaacct gctgggggcg     2040

tgcacactgt caggaccaat ttacttgatt tttgaatact gttgctatgg tgatcttctc     2100

aactatctaa gaagtaaaag agaaaaattt cacaggactt ggacagagat tttcaaggaa     2160

cacaatttca gtttttaccc cactttccaa tcacatccaa attccagcat gcctggttca     2220

agagaagttc agatacaccc ggactcggat caaatctcag ggcttcatgg gaattcattt     2280

cactctgaag atgaaattga atatgaaaac caaaaaaggc tggaagaaga ggaggacttg     2340

aatgtgctta catttgaaga tcttctttgc tttgcatatc aagttgccaa aggaatggaa     2400

tttctggaat ttaagtcgtg tgttcacaga gacctggccg ccaggaacgt gcttgtcacc     2460

cacgggaaag tggtgaagat atgtgacttt ggattggctc gagatatcat gagtgattcc     2520

aactatgttg tcaggggcaa tgcccgtctg cctgtaaaat ggatggcccc cgaaagcctg     2580

tttgaaggca tctacaccat taagagtgat gtctggtcat atggaatatt actgtgggaa     2640

atcttctcac ttggtgtgaa tccttaccct ggcattccgg ttgatgctaa cttctacaaa     2700

ctgattcaaa atggatttaa aatggatcag ccattttatg ctacagaaga aatatacatt     2760

ataatgcaat cctgctgggc ttttgactca aggaaacggc catccttccc taatttgact     2820

tcgtttttag gatgtcagct ggcagatgca gaagaagcga tgtatcagaa tgtggatggc     2880

cgtgtttcgg aatgtcctca cacctaccaa aacaggcgac ctttcagcag agagatggat     2940

ttggggctac tctctccgca ggctcaggtc gaagattcgt ag                        2982


<210>  74
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


