                         SEQUENCE LISTING

<110>  The University of Nottingham
 
<120>  Glycans as functional cancer targets and antibodies thereto

<130>  JA70261P.WOP

<150>  GB1319374.3
<151>  2013-11-01

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  475
<212>  PRT
<213>  Mus musculus

<400>  1

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Val Ile Asn Pro Ala Ile Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Glu Arg Phe Thr Ile Leu Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Ser Arg Ser Thr Met Ile Thr Thr Arg Asp Pro 
        115                 120                 125             


Ser Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Val Pro Gly Cys 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Lys Trp Asn Tyr Gly Ala Leu Ser 
            180                 185                 190         


Ser Gly Val Arg Thr Val Ser Ser Val Leu Gln Ser Gly Phe Tyr Ser 
        195                 200                 205             


Leu Ser Ser Leu Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr 
    210                 215                 220                 


Val Ile Cys Asn Val Ala His Pro Ala Ser Lys Thr Glu Leu Ile Lys 
225                 230                 235                 240 


Arg Ile Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Cys Pro Pro Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser 
    290                 295                 300                 


Trp Phe Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg 
305                 310                 315                 320 


Glu Ala Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile 
                325                 330                 335     


Gln His Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        355                 360                 365             


Gly Arg Ala Gln Thr Pro Gln Val Tyr Thr Ile Pro Pro Pro Arg Glu 
    370                 375                 380                 


Gln Met Ser Lys Lys Lys Val Ser Leu Thr Cys Leu Val Thr Asn Phe 
385                 390                 395                 400 


Phe Ser Glu Ala Ile Ser Val Glu Trp Glu Arg Asn Gly Glu Leu Glu 
                405                 410                 415     


Gln Asp Tyr Lys Asn Thr Pro Pro Ile Leu Asp Ser Asp Gly Thr Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Thr Asp Ser Trp Leu Gln Gly 
        435                 440                 445             


Glu Ile Phe Thr Cys Ser Val Val His Glu Ala Leu His Asn His His 
    450                 455                 460                 


Thr Gln Lys Asn Leu Ser Arg Ser Pro Gly Lys 
465                 470                 475 


<210>  2
<211>  1425
<212>  DNA
<213>  Mus musculus

<400>  2
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatga actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ttattaatcc tgcaatatac      240

tatgctgagt ctgtgaaaga gaggttcacc atattaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggaa tttattactg ttccaggtct      360

actatgatta cgacaaggga cccgtcccgg tacttcgatg tctggggcgc agggaccacg      420

gtcaccgtct cctcagctac aacaacagcc ccatctgtct atcccttggt ccctggctgc      480

agtgacacat ctggatcctc ggtgacactg ggatgccttg tcaaaggcta cttccctgag      540

ccggtaactg taaaatggaa ctatggagcc ctgtccagcg gtgtgcgcac agtctcatct      600

gtcctgcagt ctgggttcta ttccctcagc agcttggtga ctgtaccctc cagcacctgg      660

cccagccaga ctgtcatctg caacgtagcc cacccagcca gcaagactga gttgatcaag      720

agaatcgagc ctagaatacc caagcccagt acccccccag gttcttcatg cccacctggt      780

aacatcttgg gtggaccatc cgtcttcatc ttccccccaa agcccaagga tgcactcatg      840

atctccctaa cccccaaggt tacgtgtgtg gtggtggatg tgagcgagga tgacccagat      900

gtccatgtca gctggtttgt ggacaacaaa gaagtacaca cagcctggac acagccccgt      960

gaagctcagt acaacagtac cttccgagtg gtcagtgccc tccccatcca gcaccaggac     1020

tggatgaggg gcaaggagtt caaatgcaag gtcaacaaca aagccctccc agcccccatc     1080

gagagaacca tctcaaaacc caaaggaaga gcccagacac ctcaagtata caccataccc     1140

ccacctcgtg aacaaatgtc caagaagaag gttagtctga cctgcctggt caccaacttc     1200

ttctctgaag ccatcagtgt ggagtgggaa aggaacggag aactggagca ggattacaag     1260

aacactccac ccatcctgga ctcagatggg acctacttcc tctacagcaa gctcactgtg     1320

gatacagaca gttggttgca aggagaaatt tttacctgct ccgtggtgca tgaggctctc     1380

cataaccacc acacacagaa gaacctgtct cgctcccctg gtaaa                     1425


<210>  3
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 
        35                  40                  45              


Ile His Asn Phe Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Val Leu Val Tyr Asn Ala Lys Thr Leu Pro Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Thr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  4
<211>  702
<212>  DNA
<213>  Mus musculus

<400>  4
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccaacctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gaacaagtga gaatattcac aattttttaa catggtatca gcagaaacag      180

ggaaaatctc ctcaggtcct ggtctataat gcaaaaacct taccagatgg tgtgccatca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      300

gaagattttg ggacttatta ctgtcaacat ttttggagta gtccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         702


<210>  5
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Tyr Leu Gly Leu Asn Cys Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Val Ile Asn Pro Ala Ile Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Glu Arg Phe Thr Ile Leu Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Ser Arg Ser Thr Met Ile Thr Thr Arg Asp Pro 
        115                 120                 125             


Ser Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  6
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtacttgg gactgaactg tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaaactcg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatga actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ttattaatcc tgcaatatac      240

tatgctgagt ctgtgaaaga gaggttcacc atattaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggaa tttattactg ttccaggtct      360

actatgatta cgacaaggga cccgtcccgg tacttcgatg tctggggcgc agggaccacg      420

gtcaccgtct ccagcgcttc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1425


<210>  7
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 
        35                  40                  45              


Ile His Asn Phe Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Val Leu Val Tyr Asn Ala Lys Thr Leu Pro Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  8
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  8
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccaacctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gaacaagtga gaatattcac aattttttaa catggtatca gcagaaacag      180

ggaaaatctc ctcaggtcct ggtctataat gcaaaaacct taccagatgg tgtgccatca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      300

gaagattttg ggacttatta ctgtcaacat ttttggagta gtccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgtacggta gcgccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


<210>  9
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Ile Asn Pro Ala Ile Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Leu Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Ser Arg Ser Thr Met Ile Thr Thr Arg Asp Pro 
        115                 120                 125             


Ser Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Val Pro Gly Cys 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Lys Trp Asn Tyr Gly Ala Leu Ser 
            180                 185                 190         


Ser Gly Val Arg Thr Val Ser Ser Val Leu Gln Ser Gly Phe Tyr Ser 
        195                 200                 205             


Leu Ser Ser Leu Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr 
    210                 215                 220                 


Val Ile Cys Asn Val Ala His Pro Ala Ser Lys Thr Glu Leu Ile Lys 
225                 230                 235                 240 


Arg Ile Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Cys Pro Pro Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser 
    290                 295                 300                 


Trp Phe Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg 
305                 310                 315                 320 


Glu Ala Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile 
                325                 330                 335     


Gln His Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        355                 360                 365             


Gly Arg Ala Gln Thr Pro Gln Val Tyr Thr Ile Pro Pro Pro Arg Glu 
    370                 375                 380                 


Gln Met Ser Lys Lys Lys Val Ser Leu Thr Cys Leu Val Thr Asn Phe 
385                 390                 395                 400 


Phe Ser Glu Ala Ile Ser Val Glu Trp Glu Arg Asn Gly Glu Leu Glu 
                405                 410                 415     


Gln Asp Tyr Lys Asn Thr Pro Pro Ile Leu Asp Ser Asp Gly Thr Tyr 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Thr Asp Ser Trp Leu Gln Gly 
        435                 440                 445             


Glu Ile Phe Thr Cys Ser Val Val His Glu Ala Leu His Asn His His 
    450                 455                 460                 


Thr Gln Lys Asn Leu Ser Arg Ser Pro Gly Lys 
465                 470                 475 


<210>  10
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  10
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgttgcct ctggattcac ttttagtgac gcctggatga actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ctattaatcc tgcaatatac      240

tatgctgagt ctgtgaaagg gaggttcacc atattaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggaa tttattactg ttccaggtct      360

actatgatta cgacaaggga cccgtcccgg tacttcgatg tctggggcgc agggaccacg      420

gtcaccgtct cctcagctac aacaacagcc ccatctgtct atcccttggt ccctggctgc      480

agtgacacat ctggatcctc ggtgacactg ggatgccttg tcaaaggcta cttccctgag      540

ccggtaactg taaaatggaa ctatggagcc ctgtccagcg gtgtgcgcac agtctcatct      600

gtcctgcagt ctgggttcta ttccctcagc agcttggtga ctgtaccctc cagcacctgg      660

cccagccaga ctgtcatctg caacgtagcc cacccagcca gcaagactga gttgatcaag      720

agaatcgagc ctagaatacc caagcccagt acccccccag gttcttcatg cccacctggt      780

aacatcttgg gtggaccatc cgtcttcatc ttccccccaa agcccaagga tgcactcatg      840

atctccctaa cccccaaggt tacgtgtgtg gtggtggatg tgagcgagga tgacccagat      900

gtccatgtca gctggtttgt ggacaacaaa gaagtacaca cagcctggac acagccccgt      960

gaagctcagt acaacagtac cttccgagtg gtcagtgccc tccccatcca gcaccaggac     1020

tggatgaggg gcaaggagtt caaatgcaag gtcaacaaca aagccctccc agcccccatc     1080

gagagaacca tctcaaaacc caaaggaaga gcccagacac ctcaagtata caccataccc     1140

ccacctcgtg aacaaatgtc caagaagaag gttagtctga cctgcctggt caccaacttc     1200

ttctctgaag ccatcagtgt ggagtgggaa aggaacggag aactggagca ggattacaag     1260

aacactccac ccatcctgga ctcagatggg acctacttcc tctacagcaa gctcactgtg     1320

gatacagaca gttggttgca aggagaaatt tttacctgct ccgtggtgca tgaggctctc     1380

cataaccacc acacacagaa gaacctgtct cgctcccctg gtaaa                     1425


<210>  11
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 
        35                  40                  45              


Ile His Asn Phe Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Val Leu Val Tyr Asn Ala Lys Thr Leu Pro Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Glu Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  12
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  12
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccaacctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gaacaagtga gattattcac aattttttaa catggtatca gcagaaacag      180

ggaaaatctc ctcaggtcct ggtctataat gcaaaaacct taccagatgg tgtgccatca      240

aggttcagtg gcagtggatc agaaacacaa tattctctca agatcaacag cctgcagcct      300

gaagattttg ggacttatta ctgtcaacat ttttggagta gtccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         702


<210>  13
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Ile Asn Pro Ala Ile Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Leu Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Ser Thr Met Ile Thr Thr Arg Asp Pro Ser Arg Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
145                 150                 155                 160 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
                165                 170                 175     


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
            180                 185                 190         


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
        195                 200                 205             


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
    210                 215                 220                 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
225                 230                 235                 240 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
                245                 250                 255     


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            260                 265                 270         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly Lys 
                485     


<210>  14
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  14
atgtacttgg gactgaactg tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaaactcg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgttgcct ctggattcac ttttagtgac gcctggatga actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ctattaatcc tgcaatatac      240

tatgctgagt ctgtgaaagg gaggttcacc atattaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggaa tttattactg ttccaggtct      360

actatgatta cgacaaggga cccgtcccgg tacttcgatg tctggggcgc agggaccacg      420

gtcaccgtct ccagcgcttc caccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcaccg tctggggcgc agggaccacg gtcaccgtct ccagcgcttc caccaagggc      540

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      600

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      660

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      720

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      780

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      840

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      900

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      960

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1020

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1080

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1140

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1200

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1260

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1320

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1380

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1440

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1500

ctgtctccgg gtaaa                                                      1515


<210>  15
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 
        35                  40                  45              


Ile His Asn Phe Leu Thr Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Val Leu Val Tyr Asn Ala Lys Thr Leu Pro Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  16
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  16
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccaacctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gaacaagtga gaatattcac aattttttaa catggtatca gcagaaacag      180

ggaaaatctc ctcaggtcct ggtctataat gcaaaaacct taccagatgg tgtgccatca      240

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      300

gaagattttg ggacttatta ctgtcaacat ttttggagta gtccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgtacggta gcgccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


