                         SEQUENCE LISTING

<110>  Kapurniotu, Aphrodite
 
<120>  Modified segments of islet amyloid polypeptide

<130>  203908

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  37
<212>  PRT
<213>  human

<400>  1

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  2
<211>  11
<212>  PRT
<213>  human

<400>  2

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His 
1               5                   10      


<210>  3
<211>  7
<212>  PRT
<213>  human

<400>  3

Asn Phe Gly Ala Ile Leu Ser 
1               5           


<210>  4
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  4

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Gly Gly Gly Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  5
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  5

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala Ala Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  6

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Val Val Val Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  7

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu Leu Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  8

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ile Ile Ile Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = Nle (norleucine)

<400>  9

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = 2-Aoc (2-aminooctanoic acid)

<400>  10

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  11
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  11

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Phe Phe Phe Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = ChA (cyclohexylalanin)

<400>  12

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = Dap (2,3-diaminopropionic acid)

<400>  13

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  14
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  14

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Lys Lys Lys Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  15
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = acetylated lysine

<400>  15

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  16

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Arg Arg Arg Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = ornithine

<400>  17

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  18
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  18

Lys Lys Lys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  19
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  19

Lys Lys Lys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu 
1               5                   10                  15      


Leu Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  20
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  20

Glu Glu Glu Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  21
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  21

Glu Glu Glu Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Glu Glu Glu 
            20                  25          


<210>  22
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP

<400>  22

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Pro Pro Pro Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  23
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = Aoc (8-aminooctanoic acid)

<400>  23

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  24
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = Adc (8-aminodecanoic acid)

<400>  24

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  25
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = p-aminomethylbenzoic acid covalently linked via amide bond 
       with p-aminobenzoic acid

<400>  25

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  26
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  26

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Gly Gly Gly Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  27
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  27

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala Ala Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  28
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  28

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Val Val Val Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  29
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  29

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu Leu Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  30
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  30

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ile Ile Ile Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = Nle (norleucine)

Gly-17 and Ile-19 are N-methylated

<400>  31

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  32
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = 2-Aoc (2-aminooctanoic acid)

       Gly-17 and Ile-19 are N-methylated

<400>  32

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  33
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  33

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Phe Phe Phe Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  34
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = ChA (cyclohexylalanin)

Gly-17 and Ile-19 are N-methylated

<400>  34

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  35
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = Dap (2-3-diaminopropionic acid)

       Gly-17 and Ile-19 are N-methylated

<400>  35

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  36
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  36

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Lys Lys Lys Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = acetylated lysine

Gly-17 and Ile-19 are N-methylated

<400>  37

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  38

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Arg Arg Arg Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa = ornithine

Gly-17 and Ile-19 are N-methylated

<400>  39

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Xaa Xaa Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  40
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-20 and Ile-22 are N-methylated

<400>  40

Lys Lys Lys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  41
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-20 and Ile-22 are N-methylated

<400>  41

Lys Lys Lys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu 
1               5                   10                  15      


Leu Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  42
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-20 and Ile-22 are N-methylated

<400>  42

Glu Glu Glu Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Lys Lys Lys 
            20                  25          


<210>  43
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-20 and Ile-22 are N-methylated

<400>  43

Glu Glu Glu Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala 
1               5                   10                  15      


Ala Asn Phe Gly Ala Ile Leu Ser Glu Glu Glu 
            20                  25          


<210>  44
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Gly-17 and Ile-19 are N-methylated

<400>  44

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Pro Pro Pro Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  45
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = Aoc (8-aminooctanoic acid)

       Gly-15 and Ile-17 are N-methylated

<400>  45

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  46
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = Adc (8-aminodecanoic acid)

       Gly-15 and Ile-17 are N-methylated

<400>  46

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  47
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = p-aminomethylbenzoic acid covalently linked via amide bond 
       with p-aminobenzoic acid

Gly-15 and Ile-17 are N-methylated

<400>  47

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Xaa Asn Phe Gly Ala 
1               5                   10                  15      


Ile Leu Ser 
            


<210>  48
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Ala-6, Leu-9, Val-10, Gly-17 and Ile-19 are N-methylated

<400>  48

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala Ala Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  49
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Leu-9, Gly-17 and Ile-19 are N-methylated

<400>  49

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala Ala Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  50
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Ala-6, Leu-9, Val-10, Gly-17 and Ile-19 are N-methylated

<400>  50

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu Leu Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  51
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Leu-9, Gly-17 and Ile-19 are N-methylated

<400>  51

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu Leu Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  52
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Ala-6, Leu-9 and Val-10 are N-methylated

<400>  52

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Leu Leu Leu Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  53
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified IAPP


<220>
<221>  MISC_FEATURE
<223>  Leu-5, Ala-6, Leu-9 and Val-10 are N-methylated

<400>  53

Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ala Ala Ala Asn Phe 
1               5                   10                  15      


Gly Ala Ile Leu Ser 
            20      


<210>  54
<211>  37
<212>  PRT
<213>  human


<220>
<221>  MISC_FEATURE
<223>  Gly-24 and Ile-26 are N-methylated

<400>  54

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  55
<211>  40
<212>  PRT
<213>  human

<400>  55

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  56
<211>  42
<212>  PRT
<213>  human

<400>  56

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


