б

<110>  ҽҩƼ޹˾
<120>  һֳЧ˴ݼںϵ
<130>  2013
<160>  5     
<170>  PatentIn version 3.5
<210>  1
<211>  1482
<212>  DNA
<213>  hFSH-CTP-hFSH-L-vIgG2Fc
<400>  1

atgaagaccc tgcagttctt tttcctgttt tgctgttgga aggcaatctg ctgtaactca        60
tgtgagctga ctaatatcac cattgccatc gaaaaagagg aatgcaggtt ctgtattagt       120
atcaacacta cctggtgcgc tggctactgt tatacaaggg atctggtgta taaggaccca       180
gcacggccca aaatccagaa gacatgcact ttcaaagaac tggtgtacga gactgtgagg       240
gtccctggct gtgcccacca tgctgattcc ctgtacactt atccagtggc cacccagtgc       300
cactgtggaa agtgcgatag tgactcaaca gactgtactg tgcgaggcct gggaccttct       360
tactgcagtt ttggcgaaat gaaggagccc cgtttccagg attccagctc tagtaaagct       420
ccccctcctt ccctgccctc accctcaaga ctgcctggac cttccgacac tcccatcctg       480
ccacaggccc ccgatgtgca ggactgccct gaatgtactc tgcaggagaa ccccttcttt       540
tctcagcccg gcgctcctat cctgcagtgt atgggatgct gttttagtag agcatatcct       600
accccactgc gctcaaagaa aacaatgctg gtccagaaga atgtgacaag cgaatctact       660
tgctgtgtgg ctaaatccta caaccgcgtg accgtgatgg gcggcttcaa ggtggagaat       720
cacacagcat gccattgttc tacttgctac taccataaga gtggatccgg tggcggttcc       780
ggtggaggcg gaagcggcgg tggaggatca gtggagtgcc ctccatgtcc agcaccccct       840
gtcgcaggtc catctgtgtt cctgtttcca cccaagccta aagacactct gatgatctcc       900
cgcaccccag aagtcacctg tgtggtcgtg gatgtgagcc atgaagaccc cgaggtccag       960
ttcaattggt acgtggatgg cgtcgaggtg cacaacgcta agacaaaacc tagagaagag      1020
cagttcaact ctacctttcg cgtcgtgagt gtgctgacag tcgtgcacca ggactggctg      1080
aatggcaagg agtataagtg caaagtgagc aacaaaggac tgcctgcctc aatcgaaaag      1140
actatttcca agaccaaagg acagccaaga gagccccagg tgtacaccct gcctccaagc      1200
cgcgaagaga tgactaaaaa tcaggtctct ctgacctgtc tggtgaaggg gttttatcct      1260
agtgatatcg ccgtggaatg ggagtcaaac ggtcagccag agaacaatta caagaccaca      1320
ccccctatgc tggacagcga tgggtctttc tttctgtata gcaaactgac agtggacaag      1380
tctcggtggc agcagggtaa cgtcttctct tgcagtgtga tgcacgaagc actgcacaat      1440
cattacaccc agaagtcact gtcactgagc ccaggaaaat ga                         1482


<210>  2
<211>  493
<212>  PRT
<213>  hFSH-CTP-hFSH-L-vIgG2Fc
<400>  2

Met Lys Thr Leu Gln Phe Phe Phe Leu Phe Cys Cys Trp Lys Ala Ile 
1               5                   10                  15      

Cys Cys Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
            20                  25                  30          

Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
        35                  40                  45              

Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
    50                  55                  60                  

Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
65                  70                  75                  80  

Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
                85                  90                  95      

Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
            100                 105                 110         

Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
        115                 120                 125             

Glu Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
    130                 135                 140                 

Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
145                 150                 155                 160 

Pro Gln Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu 
                165                 170                 175     

Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly 
            180                 185                 190         

Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr 
        195                 200                 205             

Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala 
    210                 215                 220                 

Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn 
225                 230                 235                 240 

His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser Gly Ser 
                245                 250                 255     

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Glu 
            260                 265                 270         

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        275                 280                 285             

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
            340                 345                 350         

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             

Val Ser Asn Lys Gly Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
        435                 440                 445             

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490             



<210>  3
<211>  92
<212>  PRT
<213>  hFSH  
<400>  3

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
1               5                   10                  15      

Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
            20                  25                  30          

Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
        35                  40                  45              

Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
    50                  55                  60                  

Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
65                  70                  75                  80  

Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90          


<210>  4
<211>  33
<212>  PRT
<213>  CTP
<400>  4

Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
1               5                   10                  15

Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro
            20                  25                  30
Gln


<210>  5
<211>  111
<212>  PRT
<213>  hFSH °
<400>  5

Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys Glu Glu 
1               5                   10                  15      

Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly Tyr Cys 
            20                  25                  30          

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
        35                  40                  45              

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro 
    50                  55                  60                  

Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val Ala Thr 
65                  70                  75                  80  

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr Val 
                85                  90                  95      

Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys Glu 
            100                 105                 110     

