                         SEQUENCE LISTING

<110>  Lpath, Inc.
       Wojciak, Jon
       Dickerson, Cindy
       Visentin, Barbara
       Sabbadini, Roger
 
<120>  COMPOSITIONS AND METHODS FOR BINDING CYSTEINYL LEUKOTRIENES 
       (cysLTs) FOR TREATMENT OF DISEASE

<130>  LPT-3500-PC

<150>  US 61/895,896
<151>  2013-10-25

<150>  US 61/909,845
<151>  2013-11-27

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  1
tatgcaaggc ttacaaccac a                                                 21


<210>  2
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  2
ggccacgcgt cgactagtac gggggggggg                                        30


<210>  3
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  3
cacaattttc ttgtccacct tggtgc                                            26


<210>  4
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  4
ccttgaccag gcatccca                                                     18


<210>  5
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  5
ctcattcctg ttgaagctct tgacaat                                           27


<210>  6
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  6
ctcattcctg ttgaagctct tgacaatggg                                        30


<210>  7
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  7
agttgttcaa gaagcacacg a                                                 21


<210>  8
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His 
1               5                   10  


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Arg Val Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  10
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Pro Leu Tyr Tyr Tyr Asp Gly Arg Ser Gly Tyr 
1               5                   10          


<210>  11
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  11

Arg Ala Ser Ser Asp Val Arg Tyr Met Tyr 
1               5                   10  


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Tyr Thr Ser Asn Leu Ala Ser 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Gln Phe Thr Thr Ser Pro Trp Thr 
1               5                   


<210>  14
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Tyr Tyr Ile His 
1               5   


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  16

Gly Tyr Ser Ile Thr Ser Ser Tyr Ser Trp Asn 
1               5                   10      


<210>  17
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  17

Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  18

000 
          


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  19

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Gly 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  20

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  21

Leu Gln Tyr Ala Ser Phe Pro Arg Thr 
1               5                   


<210>  22
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  22

Ser Ser Tyr Ser Trp Asn 
1               5       


<210>  23
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Tyr Ser Ile Thr Ser Ser Tyr 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Tyr Ile Phe Thr Asn Tyr Trp Met His 
1               5                   10  


<210>  25
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  25

Arg Ile His Pro Ser Asp Ser Asp Thr Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  26

Thr Leu Lys Trp Asp Val Gly Tyr 
1               5               


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Ser Ala Ser Ser Ser Ile Asn Ser Thr Tyr 
1               5                   10  


<210>  28
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Thr Ser Thr Leu Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Ala Ser Ser Ser Ile Asn Ser Met Tyr 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  31

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  32
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  32

Arg Ile Leu Pro Ser Asn Ser Asp Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  33
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  33

Thr Leu Asn Trp Asp Val Gly Tyr 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  34

Ser Ala Ser Ser Ser Val Ser Ser Met Tyr 
1               5                   10  


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

Arg Thr Ser Lys Leu Ala Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  X=unknown

<400>  37

Gly Tyr Xaa Phe Thr Xaa Tyr Xaa Xaa His 
1               5                   10  


<210>  38
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  X=unknown

<400>  38

Arg Xaa Xaa Pro Xaa Xaa Xaa Xaa Thr Xaa Tyr Asn Gln Lys Phe Xaa 
1               5                   10                  15      


Xaa 
    


<210>  39
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  X=unknown

<400>  39

Thr Leu Xaa Trp Asp Val Gly Tyr 
1               5               


<210>  40
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  X=unknown

<400>  40

Xaa Ala Ser Ser Xaa Xaa Xaa Xaa Xaa Tyr 
1               5                   10  


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  X=unknown

<400>  41

Xaa Thr Ser Xaa Leu Ala Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  X= unknown

<400>  42

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  43
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  43

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Met Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Pro Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Pro Leu Tyr Tyr Tyr Asp Gly Arg Ser Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  44
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  44

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Thr Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Asp Val Arg Tyr Met 
            20                  25                  30          


Tyr Trp His Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  45
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  45

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Arg Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  46
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln 
            100                 105         


<210>  47
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  47

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Arg Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Leu Lys Trp Asp Val Gly Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  48
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Ser Thr 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105     


<210>  49
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  49

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Ser Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105     


<210>  50
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  50

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Leu Pro Ser Asn Ser Asp Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Leu Asn Trp Asp Val Gly Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  51
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  51

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Pro Trp Ile Cys 
        35                  40                  45              


Arg Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105     


<210>  52
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  52

Lys Leu Ala Ala Thr Met Lys His Leu Trp Phe Phe Leu Leu Leu Val 
1               5                   10                  15      


Ala Ala Pro Arg Trp Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly 
            20                  25                  30          


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 
        35                  40                  45              


Ser Gly Tyr Ser Ile Thr Ser Ser Tyr Ser Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Tyr Tyr Ser Gly 
65                  70                  75                  80  


Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
            100                 105                 110         


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Arg Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140 


<210>  53
<211>  425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  53
aagcttgccg ccaccatgaa acatctgtgg ttcttccttc tcctggtggc agctcccaga       60

tgggtcctgt cccaagtgca gttgcaggaa tcaggcccag gcctggtgaa accaagcgag      120

acactgagct tgacctgcac tgtgtccggt tactcaatca cctcctctta cagctggaac      180

tggatcaggc agccacctgg aaagggcctt gagtggatcg ggaatatcta ttactctggc      240

tccactaact ataatccttc cctgaaatcc agggtgacca tttctgttga tacaagtaaa      300

aaccagttct ctcttaaact ttctagtgtg actgcagcag atacagcagt ctattattgt      360

gcccgacccc gggtttgggg ccagggaacc actgtaaccg tttcttctgc cagcaccaag      420

ggccc                                                                  425


<210>  54
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  55
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  55
aagcttgccg ccaccatgga catgagggtc cccgctcagc tcctggggct cctgctactc       60

tggctccgag gtgccagatg tgacatccag atgacacagt caccatcttc ccttagcgcc      120

tctgttggcg accgcgtcac cattacttgt agagctagcc aggagatttc tggctatctc      180

ggctggtatc aacaaaaacc cggtaaagct ccaaagctgc tcatctatgc tgctagcact      240

cttgactctg gtgttccatc tcgcttctca ggtagtgggt ccgggactga tttcaccctc      300

actatttcta gcctgcagcc tgaagacttc gccacttact attgcctgca gtacgcatct      360

ttcccacgga catttggaca gggcaccaaa cttgagataa agcgtacg                   408


<210>  56
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  56

Lys Leu Ala Ala Thr Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Trp Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Gly Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr 
65                  70                  75                  80  


Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135     


<210>  57
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  58
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  59
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  59

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  60
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  61
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  62
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  63
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  63

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  64
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  65
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Arg Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  69
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Arg Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  74
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  74

Gly Tyr Ser Ile Thr Ser Gly Tyr Ser Trp Asn 
1               5                   10      


<210>  75
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  75

Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Gly Trp 
1               5                   10          


<210>  76
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  76

Leu Gln Tyr Ala Arg Phe Pro Arg Thr 
1               5                   


