                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
       Yang, Jing
       Ouwehand, Willem 

 
<120>  DIAGNOSTIC METHODS FOR PAR4 ANTAGONIST THERAPY

<130>  3338.006PC01/C-K/NPS

<140>  To be assigned
<141>  Herewith

<150>  61/895,968
<151>  2013-10-25

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Ala Tyr Pro Gly Lys Phe 
1               5       


<210>  2
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  2

Ala Tyr Pro Gly Trp Leu Val Lys Asn Gly 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  3

Ala Xaa Pro Gly Trp Leu Val Lys Asn Gly 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  4

Ala Xaa Pro Gly Trp Leu Val Lys Asn 
1               5                   


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  5

Ala Xaa Pro Gly Trp Leu Val Lys 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  6

Ala Xaa Pro Gly Trp Leu Val 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  7

Ala Xaa Pro Gly Trp Leu 
1               5       


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  8

Ala Xaa Pro Gly Trp 
1               5   


<210>  9
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  9

Ala Xaa Pro Gly 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Ala Tyr Pro Gly 
1               


<210>  11
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Ala Tyr Pro Gly Gln Val Cys Ala Asn Asp 
1               5                   10  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Trp(5-OH)

<400>  12

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = (D,L)-Trp(5-Br)

<400>  13

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  14

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Bzt

<400>  15

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Tpi

<400>  16

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  17

Ala Xaa Pro Gly His Leu Val 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Tza

<400>  18

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 3-Thi

<400>  19

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 3-Fur

<400>  20

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = His(Bzl)

<400>  21

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  22

Ala Xaa Pro Gly Phe Leu Val 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<400>  23

Ala Xaa Pro Gly Tyr Leu Val 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Phe(penta-F)

<400>  24

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 2-Pya

<400>  25

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 3-Pya

<400>  26

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 4-Pya

<400>  27

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Dpa

<400>  28

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 3-Pya(4-Tolyl)

<400>  29

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Bip(2-Methyl)

<400>  30

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-Naphthyl-Ala

<400>  31

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 2-Naphthyl-Ala

<400>  32

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Tyr(Bzl)

<400>  33

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Phe(4-F)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Styryl-Ala

<400>  34

Ala Xaa Pro Gly Xaa Leu Val 
1               5           


<210>  35
<211>  866
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  DOMAIN
<222>  (623)..(864)
<223>  C-terminal domain

<400>  35

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  36
<211>  491
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(30)

<220>
<221>  DOMAIN
<222>  (232)..(488)
<223>  C-terminal domain

<400>  36

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  37
<211>  453
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(26)

<220>
<221>  DOMAIN
<222>  (170)..(416)
<223>  C-terminal domain

<400>  37

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  38
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val 
1               5                   10                  15      


Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu 
            20                  25                  30          


Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr 
        35                  40                  45              


Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr 
    50                  55                  60                  


Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn 
65                  70                  75                  80  


Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys 
                85                  90                  95      


Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn 
            100                 105                 110         


Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn 
        115                 120                 125             


Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys 
    130                 135                 140                 


Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr 
145                 150                 155                 160 


Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu 
                165                 170                 175     


Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro 
            180                 185                 190         


Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His 
        195                 200                 205             


Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser 
    210                 215                 220                 


Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser 
225                 230                 235                 240 


Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln 
                245                 250                 255     


Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn 
            260                 265                 270         


Met Thr Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys 
        275                 280                 285             


Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val 
    290                 295                 300                 


Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys 
305                 310                 315                 320 


Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp 
                325                 330                 335     


Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe 
            340                 345                 350         


Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys 
        355                 360                 365             


Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile 
    370                 375                 380                 


Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser 
385                 390                 395                 400 


Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys 
                405                 410                 415     


Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn 
            420                 425                 430         


Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys 
        435                 440                 445             


Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro 
    450                 455                 460                 


Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu 
465                 470                 475                 480 


Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly 
                485                 490                 495     


Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro 
            500                 505                 510         


Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly 
        515                 520                 525             


Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr 
    530                 535                 540                 


Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp 
545                 550                 555                 560 


Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe 
                565                 570                 575     


Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe 
            580                 585                 590         


Asn Val Gly Ser Thr Cys His Phe Ser Cys Asp Asn Gly Phe Lys Leu 
        595                 600                 605             


Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala 
    610                 615                 620                 


Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Leu 
625                 630                 635                 640 


Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg 
                645                 650                 655     


His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys 
            660                 665                 670         


Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro 
        675                 680                 685             


Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys 
    690                 695                 700                 


Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu 
705                 710                 715                 720 


Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu 
                725                 730                 735     


Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly 
            740                 745                 750         


His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile 
        755                 760                 765             


Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly 
    770                 775                 780                 


Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg 
785                 790                 795                 800 


Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly 
                805                 810                 815     


Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro 
            820                 825                 830 


<210>  39
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  39

Ser Phe Phe Leu Arg Arg 
1               5       


