                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
 
<120>  Anti-PD-L1 Monoclonal Antibodies And Fragments Thereof

<130>  DFS-126.25

<140>  PCT/US2014/062149
<141>  2014-10-24

<150>  61/895,543
<151>  2013-10-25

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Homo sapiens PD-L1m 
       C-terminal peptide"

<400>  1

Cys Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu 
1               5                   10                  15      


Glu Glu Thr 
            


<210>  2
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK amino acid 
       sequence"

<400>  2

Met Arg Cys Leu Val Gln Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ser Thr Ala Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys 
    130         


<210>  3
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK cDNA sequence"

<400>  3
atgaggtgcc ttgttcagtt tctggggctg cttgtgctct ggatccctgg atccactgca       60

gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc      120

atctcctgca ggtccagtaa gagtctccta catagtaatg gcatcactta tttgtattgg      180

tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgatttcac actgagaatc      300

agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacctccg      360

ctcacgttcg gtgctgggac caagctggag ctgaaa                                396


<210>  4
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK signal peptide
       cDNA sequence"

<400>  4
atgaggtgcc ttgttcagtt tctggggctg cttgtgctct ggatccctgg atccactgca       60


<210>  5
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK framework 1 
       cDNA sequence"

<400>  5
gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc       60

atctcctgc                                                               69


<210>  6
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L1 cDNA 
       sequence"

<400>  6
aggtccagta agagtctcct acatagtaat ggcatcactt atttgtat                    48


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L1 amino 
       acid sequence"

<400>  7

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  8
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK framework 2 
       cDNA sequence"

<400>  8
tggtatctgc agaagccagg ccagtctcct cagctcctga tttat                       45


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L2 cDNA 
       sequence"

<400>  9
cagatgtcca accttgcctc a                                                 21


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L2 amino 
       acid sequence"

<400>  10

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  11
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK framework 3 
       cDNA sequence"

<400>  11
ggagtcccag acaggttcag tggcagtggg tcaggaactg atttcacact gagaatcagc       60

agagtggagg ctgaggatgt gggtgtttat tactgt                                 96


<210>  12
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L3 cDNA 
       sequence"

<400>  12
gctcaaaatc tagaacctcc gctcacg                                           27


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK CDR-L3 amino 
       acid sequence"

<400>  13

Ala Gln Asn Leu Glu Pro Pro Leu Thr 
1               5                   


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vK J segment cDNA
       sequence"

<400>  14
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  15
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH amino acid 
       sequence"

<400>  15

Met Lys Cys Ser Trp Val Ile Val Phe Leu Met Ala Val Val Ile Gly 
1               5                   10                  15      


Ile Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Ser Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Phe Gly Leu Asn Ile 
        35                  40                  45              


Lys Asp Tyr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Lys Thr Ala Tyr Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Tyr Thr Ser Ser Asp 
                85                  90                  95      


Thr Ala Tyr Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Lys Thr Gly Gly Tyr Asp Val Tyr Phe Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  16
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH cDNA sequence"

<400>  16
atgaaatgca gctgggtcat cgtcttcctg atggcagtgg ttataggaat caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaggtcag gggcctcagt caagttgtcc      120

tgcacagctt ttggcctcaa cattaaagac tactatatac actgggtaaa acagaggcct      180

gaacagggcc tggagtggat tggatggatt gatcctgaga atggtaaaac tgcatatgcc      240

ccgaagttcc agggcaaggc cactctgact gcatacacgt cctccgacac agcctacctg      300

cacctcagca gcctgacatc tgaggacact gccgtctatt actgtaagac tggtggttac      360

gacgtctatt ttctggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            414


<210>  17
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH signal peptide
       cDNA sequence"

<400>  17
atgaaatgca gctgggtcat cgtcttcctg atggcagtgg ttataggaat caattca          57


<210>  18
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH framework 1 
       cDNA sequence"

<400>  18
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttttggcct caacattaaa                                        90


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H1 cDNA 
       sequence"

<400>  19
gactactata tacac                                                        15


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H1 amino 
       acid sequence"

<400>  20

Asp Tyr Tyr Ile His 
1               5   


<210>  21
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH framework 2 
       cDNA sequence"

<400>  21
tgggtaaaac agaggcctga acagggcctg gagtggattg ga                          42


<210>  22
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H2 cDNA 
       sequence"

<400>  22
tggattgatc ctgagaatgg taaaactgca tatgccccga agttccaggg c                51


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H2 amino 
       acid sequence"

<400>  23

Trp Ile Asp Pro Glu Asn Gly Lys Thr Ala Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH framework 3 
       cDNA sequence"

<400>  24
aaggccactc tgactgcata cacgtcctcc gacacagcct acctgcacct cagcagcctg       60

acatctgagg acactgccgt ctattactgt aagact                                 96


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H3 cDNA 
       sequence"

<400>  25
ggtggttacg acgtctattt tctggactac                                        30


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH CDR-H3 amino 
       acid sequence"

<400>  26

Gly Gly Tyr Asp Val Tyr Phe Leu Asp Tyr 
1               5                   10  


<210>  27
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: 9A11 vH J segment cDNA
       sequence"

<400>  27
tggggtcaag gaacctcagt caccgtctcc tca                                    33


<210>  28
<211>  968
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (59)..(793)

<400>  28
gcttcccgag gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaag         58

atg agg ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg        106
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu           
1               5                   10                  15                

aac gca ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat        154
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr           
            20                  25                  30                    

ggt agc aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta        202
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu           
        35                  40                  45                        

gac ctg gct gca cta att gtc tat tgg gaa atg gag gat aag aac att        250
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile           
    50                  55                  60                            

att caa ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc        298
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser           
65                  70                  75                  80            

tac aga cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat        346
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn           
                85                  90                  95                

gct gca ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac        394
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr           
            100                 105                 110                   

cgc tgc atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg        442
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val           
        115                 120                 125                       

aaa gtc aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg        490
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val           
    130                 135                 140                           

gat cca gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac        538
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr           
145                 150                 155                 160           

ccc aag gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt        586
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser           
                165                 170                 175               

ggt aag acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat        634
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn           
            180                 185                 190                   

gtg acc agc aca ctg aga atc aac aca aca act aat gag att ttc tac        682
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr           
        195                 200                 205                       

tgc act ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg        730
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu           
    210                 215                 220                           

gtc atc cca ggt aat att ctg aat gtg tcc att aaa ata tgt cta aca        778
Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr           
225                 230                 235                 240           

ctg tcc cct agc acc tagcatgatg tctgcctatc atagtcattc agtgattgtt        833
Leu Ser Pro Ser Thr                                                       
                245                                                       

gaataaatga atgaatgaat aacactatgt ttacaaaata tatcctaatt cctcacctcc      893

attcatccaa accatattgt tacttaataa acattcagca gatatttatg gaataaaaaa      953

aaaaaaaaaa aaaaa                                                       968


<210>  29
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  30
<211>  1553
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (53)..(922)

<400>  30
cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa ag atg agg       58
                                                          Met Arg         
                                                          1               

ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg aac gca        106
Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala           
        5                   10                  15                        

ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat ggt agc        154
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser           
    20                  25                  30                            

aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta gac ctg        202
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu           
35                  40                  45                  50            

gct gca cta att gtc tat tgg gaa atg gag gat aag aac att att caa        250
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln           
                55                  60                  65                

ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc tac aga        298
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg           
            70                  75                  80                    

cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat gct gca        346
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala           
        85                  90                  95                        

ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac cgc tgc        394
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys           
    100                 105                 110                           

atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg aaa gtc        442
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val           
115                 120                 125                 130           

aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg gat cca        490
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro           
                135                 140                 145               

gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac ccc aag        538
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys           
            150                 155                 160                   

gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt ggt aag        586
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys           
        165                 170                 175                       

acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat gtg acc        634
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr           
    180                 185                 190                           

agc aca ctg aga atc aac aca aca act aat gag att ttc tac tgc act        682
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr           
195                 200                 205                 210           

ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg gtc atc        730
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile           
                215                 220                 225               

cca gaa cta cct ctg gca cat cct cca aat gaa agg act cac ttg gta        778
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val           
            230                 235                 240                   

att ctg gga gcc atc tta tta tgc ctt ggt gta gca ctg aca ttc atc        826
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile           
        245                 250                 255                       

ttc cgt tta aga aaa ggg aga atg atg gat gtg aaa aaa tgt ggc atc        874
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile           
    260                 265                 270                           

caa gat aca aac tca aag aag caa agt gat aca cat ttg gag gag acg        922
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr           
275                 280                 285                 290           

taatccagca ttggaacttc tgatcttcaa gcagggattc tcaacctgtg gtttaggggt      982

tcatcggggc tgagcgtgac aagaggaagg aatgggcccg tgggatgcag gcaatgtggg     1042

acttaaaagg cccaagcact gaaaatggaa cctggcgaaa gcagaggagg agaatgaaga     1102

aagatggagt caaacaggga gcctggaggg agaccttgat actttcaaat gcctgagggg     1162

ctcatcgacg cctgtgacag ggagaaagga tacttctgaa caaggagcct ccaagcaaat     1222

catccattgc tcatcctagg aagacgggtt gagaatccct aatttgaggg tcagttcctg     1282

cagaagtgcc ctttgcctcc actcaatgcc tcaatttgtt ttctgcatga ctgagagtct     1342

cagtgttgga acgggacagt atttatgtat gagtttttcc tatttatttt gagtctgtga     1402

ggtcttcttg tcatgtgagt gtggttgtga atgatttctt ttgaagatat attgtagtag     1462

atgttacaat tttgtcgcca aactaaactt gctgcttaat gatttgctca catctagtaa     1522

aacatggagt atttgtaaaa aaaaaaaaaa a                                    1553


<210>  31
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


