                         SEQUENCE LISTING

<110>  Salk Institute for Biological Studies
 
<120>  CHIMERIC FIBROBLAST GROWTH FACTOR (FGF) 2/FGF1 PEPTIDES AND 
       METHODS OF USE

<130>  7158-91663-02

<150>  61/893,696
<151>  2013-10-21

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  465
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(465)

<400>  1
atg gca gcc ggg agc atc acc acg ctg ccc gcc ttg ccc gag gat ggc         48
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly           
1               5                   10                  15                

ggc agc ggc gcc ttc ccg ccc ggc cac ttc aag gac ccc aag cgg ctg         96
Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu           
            20                  25                  30                    

tac tgc aaa aac ggg ggc ttc ttc ctg cgc atc cac ccc gac ggc cga        144
Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg           
        35                  40                  45                        

gtt gac ggg gtc cgg gag aag agc gac cct cac atc aag cta caa ctt        192
Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu           
    50                  55                  60                            

caa gca gaa gag aga gga gtt gtg tct atc aaa gga gtg tgt gct aac        240
Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn           
65                  70                  75                  80            

cgt tac ctg gct atg aag gaa gat gga aga tta ctg gct tct aaa tgt        288
Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys           
                85                  90                  95                

gtt acg gat gag tgt ttc ttt ttt gaa cga ttg gaa tct aat aac tac        336
Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr           
            100                 105                 110                   

aat act tac cgg tca agg aaa tac acc agt tgg tat gtg gca ctg aaa        384
Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys           
        115                 120                 125                       

cga act ggg cag tat aaa ctt gga tcc aaa aca gga cct ggg cag aaa        432
Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys           
    130                 135                 140                           

gct ata ctt ttt ctt cca atg tct gct aag agc                            465
Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser                               
145                 150                 155                               


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  3
<211>  465
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(465)

<400>  3
atg gct gcc agc ggc atc acc tcg ctt ccc gca ctg ccg gag gac ggc         48
Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly           
1               5                   10                  15                

ggc gcc gcc ttc cca cca ggc cac ttc aag gac ccc aag cgg ctc tac         96
Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr           
            20                  25                  30                    

tgc aag aac ggc ggc ttc ttc ctg cgc atc cat ccc gac ggc cgc gtg        144
Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val           
        35                  40                  45                        

gat ggc gtc cgc gag aag agc gac cca cac gtc aaa cta caa ctc caa        192
Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln           
    50                  55                  60                            

gca gaa gag aga gga gtt gtg tct atc aag gga gtg tgt gcc aac cgg        240
Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg           
65                  70                  75                  80            

tac ctt gct atg aag gaa gat gga cgg ctg ctg gct tct aag tgt gtt        288
Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val           
                85                  90                  95                

aca gaa gag tgt ttc ttc ttt gaa cga ctg gaa tct aat aac tac aat        336
Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn           
            100                 105                 110                   

act tac cgg tca cgg aaa tac tcc agt tgg tat gtg gca ctg aaa cga        384
Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg           
        115                 120                 125                       

act ggg cag tat aaa ctc gga tcc aaa acg gga cct gga cag aag gcc        432
Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala           
    130                 135                 140                           

ata ctg ttt ctt cca atg tct gct aag agc tga                            465
Ile Leu Phe Leu Pro Met Ser Ala Lys Ser                                   
145                 150                                                   


<210>  4
<211>  154
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210>  5
<211>  468
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(468)

<400>  5
atg gct gaa ggg gaa atc acc acc ttc aca gcc ctg acc gag aag ttt         48
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe           
1               5                   10                  15                

aat ctg cct cca ggg aat tac aag aag ccc aaa ctc ctc tac tgt agc         96
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser           
            20                  25                  30                    

aac ggg ggc cac ttc ctg agg atc ctt ccg gat ggc aca gtg gat ggg        144
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly           
        35                  40                  45                        

aca agg gac agg agc gac cag cac att cag ctg cag ctc agt gcg gaa        192
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu           
    50                  55                  60                            

agc gtg ggg gag gtg tat ata aag agt acc gag act ggc cag tac ttg        240
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu           
65                  70                  75                  80            

gcc atg gac acc gac ggg ctt tta tac ggc tca cag aca cca aat gag        288
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu           
                85                  90                  95                

gaa tgt ttg ttc ctg gaa agg ctg gag gag aac cat tac aac acc tat        336
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr           
            100                 105                 110                   

ata tcc aag aag cat gca gag aag aat tgg ttt gtt ggc ctc aag aag        384
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys           
        115                 120                 125                       

aat ggg agc tgc aaa cgc ggt cct cgg act cac tat ggc cag aaa gca        432
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala           
    130                 135                 140                           

atc ttg ttt ctc ccc ctg cca gtc tct tct gat taa                        468
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp                               
145                 150                 155                               


<210>  6
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  7
<211>  468
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(468)

<400>  7
atg gct gaa ggg gag atc aca acc ttc gca gcc ctg acc gag agg ttc         48
Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe           
1               5                   10                  15                

aac ctg cct cta gga aac tac aaa aag ccc aaa ctg ctc tac tgc agc         96
Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser           
            20                  25                  30                    

aac ggg ggc cac ttc ttg agg atc ctt cct gat ggc acc gtg gat ggg        144
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly           
        35                  40                  45                        

aca agg gac agg agc gac cag cac att cag ctg cag ctc agt gcg gaa        192
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu           
    50                  55                  60                            

agt gcg ggc gaa gtg tat ata aag ggt acg gag acc ggc cag tac ttg        240
Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu           
65                  70                  75                  80            

gcc atg gac acc gaa ggg ctt tta tac ggc tcg cag aca cca aat gag        288
Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu           
                85                  90                  95                

gaa tgt ctg ttc ctg gaa agg ctg gaa gaa aac cat tat aac act tac        336
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr           
            100                 105                 110                   

acc tcc aag aag cat gcg gag aag aac tgg ttt gtg ggc ctc aag aag        384
Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys           
        115                 120                 125                       

aac ggg agc tgt aag cgc ggt cct cgg act cac tat ggc cag aaa gcc        432
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala           
    130                 135                 140                           

atc ttg ttt ctg ccc ctc ccg gtg tct tct gac tag                        468
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp                               
145                 150                 155                               


<210>  8
<211>  155
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  9
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2/FGF1 chimeric protein sequence (FGF24)


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  FGF2 portion

<220>
<221>  MISC_FEATURE
<222>  (22)..(158)
<223>  FGF1 portion

<400>  9

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu 
            20                  25                  30          


Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr 
        35                  40                  45              


Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu 
    50                  55                  60                  


Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly 
65                  70                  75                  80  


Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr 
                85                  90                  95      


Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr 
            100                 105                 110         


Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly 
        115                 120                 125             


Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly 
    130                 135                 140                 


Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155             


<210>  10
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2/FGF1 chimeric protein sequence (FGF24.1)


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  FGF2 portion

<220>
<221>  MISC_FEATURE
<222>  (22)..(158)
<223>  FGF1 portion

<400>  10

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Phe Ala Phe Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu 
            20                  25                  30          


Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr 
        35                  40                  45              


Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu 
    50                  55                  60                  


Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly 
65                  70                  75                  80  


Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr 
                85                  90                  95      


Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr 
            100                 105                 110         


Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly 
        115                 120                 125             


Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly 
    130                 135                 140                 


Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155             


<210>  11
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2/FGF1 chimeric protein sequence (FGF24.2)


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  FGF2 portion

<220>
<221>  MISC_FEATURE
<222>  (22)..(158)
<223>  FGF1 portion

<400>  11

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu 
            20                  25                  30          


Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr 
        35                  40                  45              


Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu 
    50                  55                  60                  


Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly 
65                  70                  75                  80  


Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr 
                85                  90                  95      


Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr 
            100                 105                 110         


Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly 
        115                 120                 125             


Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly 
    130                 135                 140                 


Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155             


<210>  12
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2/FGF1 chimeric protein sequence (FGF24 without the MAAGSITTL 
       signal sequence)


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  FGF2 portion

<220>
<221>  MISC_FEATURE
<222>  (13)..(149)
<223>  FGF1 portion

<400>  12

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly Asn 
1               5                   10                  15      


Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu 
            20                  25                  30          


Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp 
        35                  40                  45              


Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr 
    50                  55                  60                  


Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly 
65                  70                  75                  80  


Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu 
                85                  90                  95      


Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala 
            100                 105                 110         


Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg 
        115                 120                 125             


Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu 
    130                 135                 140                 


Pro Val Ser Ser Asp 
145                 


<210>  13
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2/FGF1 chimeric protein sequence (FGF24 with an N-terminal M 
       instead of the MAAGSITTL signal sequence)


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  FGF2 portion

<220>
<221>  MISC_FEATURE
<222>  (14)..(140)
<223>  FGF1 portion

<400>  13

Met Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly 
1               5                   10                  15      


Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe 
            20                  25                  30          


Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser 
        35                  40                  45              


Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val 
    50                  55                  60                  


Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp 
65                  70                  75                  80  


Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu 
                85                  90                  95      


Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His 
            100                 105                 110         


Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys 
        115                 120                 125             


Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro 
    130                 135                 140                 


Leu Pro Val Ser Ser Asp 
145                 150 


<210>  14
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FGF24 coding sequence

<400>  14
atggccgctg gctcaatcac gacgctgccg gctctgccgg aagatggtgg ctcaggtgcc       60

tttccgccgg gtaactacaa aaaaccgaaa ctgctgtatt gcagcaacgg cggtcatttt      120

ctgcgtattc tgccggatgg caccgtcgac ggtacgcgtg atcgcagtga ccagcacatt      180

cagctgcaac tgagcgcgga atctgtgggt gaagtttata tcaaatcaac cgaaacgggc      240

cagtacctgg ccatggatac cgacggcctg ctgtacggtt cgcaaacgcc gaatgaagaa      300

tgcctgtttc tggaacgtct ggaagaaaac cattacaaca cctacatcag taaaaaacac      360

gcggagaaaa actggttcgt tggcctgaag aaaaacggtt cctgtaaacg cggcccgcgc      420

acccattacg gtcaaaaagc cattctgttt ctgccgctgc cggtttcgtc cgactaa         477


<210>  15
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FGF24.1 coding sequence

<400>  15
atggccgctg gctcaatcac gacgctgccg gctctgccgg aagatggtgg ctcattcgcc       60

tttccgccgg gtaactacaa aaaaccgaaa ctgctgtatt gcagcaacgg cggtcatttt      120

ctgcgtattc tgccggatgg caccgtcgac ggtacgcgtg atcgcagtga ccagcacatt      180

cagctgcaac tgagcgcgga atctgtgggt gaagtttata tcaaatcaac cgaaacgggc      240

cagtacctgg ccatggatac cgacggcctg ctgtacggtt cgcaaacgcc gaatgaagaa      300

tgcctgtttc tggaacgtct ggaagaaaac cattacaaca cctacatcag taaaaaacac      360

gcggagaaaa actggttcgt tggcctgaag aaaaacggtt cctgtaaacg cggcccgcgc      420

acccattacg gtcaaaaagc cattctgttt ctgccgctgc cggtttcgtc cgactaa         477


<210>  16
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FGF24.2 coding sequence

<400>  16
atggccgctg gctcaatcac gacgctgccg gctctgccgg aagatggtgg ctcattcaac       60

ctgccgccgg gtaactacaa aaaaccgaaa ctgctgtatt gcagcaacgg cggtcatttt      120

ctgcgtattc tgccggatgg caccgtcgac ggtacgcgtg atcgcagtga ccagcacatt      180

cagctgcaac tgagcgcgga atctgtgggt gaagtttata tcaaatcaac cgaaacgggc      240

cagtacctgg ccatggatac cgacggcctg ctgtacggtt cgcaaacgcc gaatgaagaa      300

tgcctgtttc tggaacgtct ggaagaaaac cattacaaca cctacatcag taaaaaacac      360

gcggagaaaa actggttcgt tggcctgaag aaaaacggtt cctgtaaacg cggcccgcgc      420

acccattacg gtcaaaaagc cattctgttt ctgccgctgc cggtttcgtc cgactaa         477


<210>  17
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human FGF1 codon optimized for improved expression in bacteria


<220>
<221>  CDS
<222>  (1)..(468)

<400>  17
atg gct gaa ggc gaa atc acg acg ttc acc gct ctg acg gaa aaa ttc         48
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe           
1               5                   10                  15                

aat ctg ccg ccg ggt aac tac aaa aaa ccg aaa ctg ctg tat tgc agc         96
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser           
            20                  25                  30                    

aac ggc ggt cat ttt ctg cgt att ctg ccg gat ggc acc gtc gac ggt        144
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly           
        35                  40                  45                        

acg cgt gat cgc agt gac cag cac att cag ctg caa ctg agc gcg gaa        192
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu           
    50                  55                  60                            

tct gtg ggt gaa gtt tat atc aaa tca acc gaa acg ggc cag tac ctg        240
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu           
65                  70                  75                  80            

gcc atg gat acc gac ggc ctg ctg tac ggt tcg caa acg ccg aat gaa        288
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu           
                85                  90                  95                

gaa tgc ctg ttt ctg gaa cgt ctg gaa gaa aac cat tac aac acc tac        336
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr           
            100                 105                 110                   

atc agt aaa aaa cac gcg gag aaa aac tgg ttc gtt ggc ctg aag aaa        384
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys           
        115                 120                 125                       

aac ggt tcc tgt aaa cgc ggc ccg cgc acg cat tac ggt cag aaa gca        432
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala           
    130                 135                 140                           

atc ctg ttc ctg ccg ctg ccg gtc tcc tcc gac taa                        468
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp                               
145                 150                 155                               


<210>  18
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


