                         SEQUENCE LISTING

<110>  Isis Pharmaceuticals, Inc.
 
<120>  METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS

<130>  DVCM0038WO

<150>  61/893,569
<151>  2013-10-21

<150>  61/952,678
<151>  2014-03-13

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
tcttggttac atgaaatccc                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
ctcagtaaca ttgacaccac                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  3
agcttnnnnn nnnnnnnnnn                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  4
agcatnnnnn nnnnnnnnnn                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  5
aatggnnnnn nnnnnnnnnn                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  6
acggcnnnnn nnnnnnnnnn                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  7
gcagannnnn nnnnnnnnnn                                                   20


<210>  8
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (4)..(17)
<223>  n is a, c, g, or t

<400>  8
ggtnnnnnnn nnnnnnn                                                      17


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  9
gcagcnnnnn nnnnnnnnnn                                                   20


<210>  10
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  n is a, c, g, or t

<400>  10
ggannnnnnn nnnnnn                                                       16


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  11
gcacannnnn nnnnnnnnnn                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  12
tgctcnnnnn nnnnnnnnnn                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  13
tggtgnnnnn nnnnnnnnnn                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  14
tgcaannnnn nnnnnnnnnn                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  15
tgtcannnnn nnnnnnnnnn                                                   20


<210>  16
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (4)..(18)
<223>  n is a, c, g, or t

<400>  16
tgannnnnnn nnnnnnnn                                                     18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  17
ttcatnnnnn nnnnnnnnnn                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  18
tcacannnnn nnnnnnnnnn                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  19
ccagcnnnnn nnnnnnnnnn                                                   20


<210>  20
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  n is a, c, g, or t

<400>  20
ctannnnnnn nnnnnn                                                       16


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  21
ccttgnnnnn nnnnnnnnnn                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  n is a, c, g, or t

<400>  22
ccttcnnnnn nnnnnnnnnn                                                   20


