                         SEQUENCE LISTING

<110>  Dyax Corp.
 
<120>  DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES

<130>  D0617.70057WO00

<150>  US 61/893,542
<151>  2013-10-21

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (15)..(29)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (39)..(50)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  Xaa can be any amino acid except for Cys

<220>
<221>  misc_feature
<222>  (56)..(58)
<223>  Xaa can be any amino acid except for Cys

<400>  1

Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Cys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa 
            20                  25                  30          


Phe Xaa Xaa Gly Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Cys Xaa Xaa Xaa Cys Xaa Xaa Xaa 
    50                  55              


<210>  2
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Glu Ala Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys 
1               5                   10                  15      


Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys 
            20                  25                  30          


Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu 
        35                  40                  45              


Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp 
    50                  55                  60  


<210>  3
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210>  4
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
1               5                   10                  15      


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
        35                  40                  45              


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
                85                  90                  95      


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
            100                 105                 110         


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
        115                 120                 125             


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
    130                 135                 140                 


Gln Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
145                 150                 155                 160 


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
                165                 170                 175     


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Val His Val Gln Lys 
            180                 185                 190         


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
    210                 215                 220                 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
225                 230                 235                 240 


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
                245                 250                 255     


Thr Ile Ala Glu Asn Ser 
            260         


<210>  5
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Val Ser Pro Pro His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu 
                405                 410                 415     


Arg Asp Ser Gly Lys Glu Gln Gly His Thr Arg Arg His Asp Trp Gly 
            420                 425                 430         


His Glu Lys Gln Arg Lys His Asn Leu Gly His Gly His Lys His Glu 
        435                 440                 445             


Arg Asp Gln Gly His Gly His Gln Arg Gly His Gly Leu Gly His Gly 
    450                 455                 460                 


His Glu Gln Gln His Gly Leu Gly His Gly His Lys Phe Lys Leu Asp 
465                 470                 475                 480 


Asp Asp Leu Glu His Gln Gly Gly His Val Leu Asp His Gly His Lys 
                485                 490                 495     


His Lys His Gly His Gly His Gly Lys His Lys Asn Lys Gly Lys Lys 
            500                 505                 510         


Asn Gly Lys His Asn Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser 
        515                 520                 525             


Glu Asp Ser Thr Thr Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly 
    530                 535                 540                 


Pro Thr Pro Ile Pro Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe 
545                 550                 555                 560 


Ser Asp Phe Gln Asp Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile 
                565                 570                 575     


Ser Pro Ala Pro Ile Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln 
            580                 585                 590         


Ile Asp Pro Asn Gly Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp 
        595                 600                 605             


Thr Thr Ser Pro Lys Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu 
    610                 615                 620                 


Ile Asn Pro Thr Thr Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr 
625                 630                 635                 640 


Asp Gly Leu Ser 
                


<210>  6
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp Leu Phe 
1               5                   10                  15      


Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn Gln Ser 
            20                  25                  30          


Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys Thr Val 
        35                  40                  45              


Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu Gly Asp 
    50                  55                  60                  


Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr Lys Asp 
65                  70                  75                  80  


Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly Lys Arg 
                85                  90                  95      


Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile Thr Pro 
            100                 105                 110         


Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly Cys Val 
        115                 120                 125             


His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu Arg His 
    130                 135                 140                 


Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu Phe Met 
145                 150                 155                 160 


Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly Leu Asn 
                165                 170                 175     


Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys Glu Asn 
            180                 185                 190         


Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly Asp Thr 
        195                 200                 205             


Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg Ile Ala 
    210                 215                 220                 


Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe Val Gln 
225                 230                 235                 240 


Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro Thr Asn 
                245                 250                 255     


Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys Leu Asn 
            260                 265                 270         


Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val Lys Lys 
        275                 280                 285             


Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp Phe Val 
    290                 295                 300                 


Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu Thr Glu 
305                 310                 315                 320 


Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn Ala Glu 
                325                 330                 335     


Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val Asn Cys 
            340                 345                 350         


Gln Pro Leu Gly Met Ile Ser Leu Met Lys 
        355                 360         


<210>  7
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr Thr Val Ser Pro Pro 
1               5                   10                  15      


His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu Arg Asp Ser Gly Lys 
            20                  25                  30          


Glu Gln Gly His Thr Arg Arg His Asp Trp Gly His Glu Lys Gln Arg 
        35                  40                  45              


Lys His Asn Leu Gly His Gly His Lys His Glu Arg Asp Gln Gly His 
    50                  55                  60                  


Gly His Gln Arg Gly His Gly Leu Gly His Gly His Glu Gln Gln His 
65                  70                  75                  80  


Gly Leu Gly His Gly His Lys Phe Lys Leu Asp Asp Asp Leu Glu His 
                85                  90                  95      


Gln Gly Gly His Val Leu Asp His Gly His Lys His Lys His Gly His 
            100                 105                 110         


Gly His Gly Lys His Lys Asn Lys Gly Lys Lys Asn Gly Lys His Asn 
        115                 120                 125             


Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser Glu Asp Ser Thr Thr 
    130                 135                 140                 


Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly Pro Thr Pro Ile Pro 
145                 150                 155                 160 


Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe Ser Asp Phe Gln Asp 
                165                 170                 175     


Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile Ser Pro Ala Pro Ile 
            180                 185                 190         


Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln Ile Asp Pro Asn Gly 
        195                 200                 205             


Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp Thr Thr Ser Pro Lys 
    210                 215                 220                 


Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu Ile Asn Pro Thr Thr 
225                 230                 235                 240 


Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr Asp Gly Leu Ser 
                245                 250                 255 


