                         SEQUENCE LISTING

<110>  Lubris, LLC
 
<120>  Control of Rheological Properties of Mixed Hyaluronate/Lubricin 
       Solutions

<130>  LUB-026WO;1237-2026WO

<150>  SN 61/894366
<151>  2013-10-22

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1404
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          


Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              


Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  


Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      


Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         


Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             


Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 


Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         


Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             


Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 


Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 


Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     


Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         


Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             


Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 


Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 


Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     


Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         


Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             


Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         


Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             


Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 


Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         


Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             


Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 


Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         


Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             


Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 


Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 


Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     


Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         


Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 


Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 


Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     


Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp Lys Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 


Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 


Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     


Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         


Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             


Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 


Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 


Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     


Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         


Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             


Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 


Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 


Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     


Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         


Thr Thr Thr Glu Ile Met Asn Lys  Pro Glu Glu Thr Ala  Lys Pro Lys 
        995                 1000                 1005             


Asp Arg  Ala Thr Asn Ser Lys  Ala Thr Thr Pro Lys  Pro Gln Lys 
    1010                 1015                 1020             


Pro Thr  Lys Ala Pro Lys Lys  Pro Thr Ser Thr Lys  Lys Pro Lys 
    1025                 1030                 1035             


Thr Met  Pro Arg Val Arg Lys  Pro Lys Thr Thr Pro  Thr Pro Arg 
    1040                 1045                 1050             


Lys Met  Thr Ser Thr Met Pro  Glu Leu Asn Pro Thr  Ser Arg Ile 
    1055                 1060                 1065             


Ala Glu  Ala Met Leu Gln Thr  Thr Thr Arg Pro Asn  Gln Thr Pro 
    1070                 1075                 1080             


Asn Ser  Lys Leu Val Glu Val  Asn Pro Lys Ser Glu  Asp Ala Gly 
    1085                 1090                 1095             


Gly Ala  Glu Gly Glu Thr Pro  His Met Leu Leu Arg  Pro His Val 
    1100                 1105                 1110             


Phe Met  Pro Glu Val Thr Pro  Asp Met Asp Tyr Leu  Pro Arg Val 
    1115                 1120                 1125             


Pro Asn  Gln Gly Ile Ile Ile  Asn Pro Met Leu Ser  Asp Glu Thr 
    1130                 1135                 1140             


Asn Ile  Cys Asn Gly Lys Pro  Val Asp Gly Leu Thr  Thr Leu Arg 
    1145                 1150                 1155             


Asn Gly  Thr Leu Val Ala Phe  Arg Gly His Tyr Phe  Trp Met Leu 
    1160                 1165                 1170             


Ser Pro  Phe Ser Pro Pro Ser  Pro Ala Arg Arg Ile  Thr Glu Val 
    1175                 1180                 1185             


Trp Gly  Ile Pro Ser Pro Ile  Asp Thr Val Phe Thr  Arg Cys Asn 
    1190                 1195                 1200             


Cys Glu  Gly Lys Thr Phe Phe  Phe Lys Asp Ser Gln  Tyr Trp Arg 
    1205                 1210                 1215             


Phe Thr  Asn Asp Ile Lys Asp  Ala Gly Tyr Pro Lys  Pro Ile Phe 
    1220                 1225                 1230             


Lys Gly  Phe Gly Gly Leu Thr  Gly Gln Ile Val Ala  Ala Leu Ser 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Lys Asn Trp  Pro Glu Ser Val Tyr  Phe Phe Lys 
    1250                 1255                 1260             


Arg Gly  Gly Ser Ile Gln Gln  Tyr Ile Tyr Lys Gln  Glu Pro Val 
    1265                 1270                 1275             


Gln Lys  Cys Pro Gly Arg Arg  Pro Ala Leu Asn Tyr  Pro Val Tyr 
    1280                 1285                 1290             


Gly Glu  Thr Thr Gln Val Arg  Arg Arg Arg Phe Glu  Arg Ala Ile 
    1295                 1300                 1305             


Gly Pro  Ser Gln Thr His Thr  Ile Arg Ile Gln Tyr  Ser Pro Ala 
    1310                 1315                 1320             


Arg Leu  Ala Tyr Gln Asp Lys  Gly Val Leu His Asn  Glu Val Lys 
    1325                 1330                 1335             


Val Ser  Ile Leu Trp Arg Gly  Leu Pro Asn Val Val  Thr Ser Ala 
    1340                 1345                 1350             


Ile Ser  Leu Pro Asn Ile Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr 
    1355                 1360                 1365             


Ala Phe  Ser Lys Asp Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg 
    1370                 1375                 1380             


Thr Ala  Arg Ala Ile Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys 
    1385                 1390                 1395             


Val Trp  Tyr Asn Cys Pro 
    1400                 


<210>  2
<211>  5040
<212>  DNA
<213>  Homo sapiens

<400>  2
gcggccgcga ctattcggta cctgaaaaca acgatggcat ggaaaacact tcccatttac       60

ctgttgttgc tgctgtctgt tttcgtgatt cagcaagttt catctcaaga tttatcaagc      120

tgtgcaggga gatgtgggga agggtattct agagatgcca cctgcaactg tgattataac      180

tgtcaacact acatggagtg ctgccctgat ttcaagagag tctgcactgc ggagctttcc      240

tgtaaaggcc gctgctttga gtccttcgag agagggaggg agtgtgactg cgacgcccaa      300

tgtaagaagt atgacaagtg ctgtcccgat tatgagagtt tctgtgcaga agtgcataat      360

cccacatcac caccatcttc aaagaaagca cctccacctt caggagcatc tcaaaccatc      420

aaatcaacaa ccaaacgttc acccaaacca ccaaacaaga agaagactaa gaaagttata      480

gaatcagagg aaataacaga agaacattct gtttctgaaa atcaagagtc ctcctcctcc      540

tcctcctctt cctcttcttc ttcaacaatt tggaaaatca agtcttccaa aaattcagct      600

gctaatagag aattacagaa gaaactcaaa gtaaaagata acaagaagaa cagaactaaa      660

aagaaaccta cccccaaacc accagttgta gatgaagctg gaagtggatt ggacaatggt      720

gacttcaagg tcacaactcc tgacacgtct accacccaac acaataaagt cagcacatct      780

cccaagatca caacagcaaa accaataaat cccagaccca gtcttccacc taattctgat      840

acatctaaag agacgtcttt gacagtgaat aaagagacaa cagttgaaac taaagaaact      900

actacaacaa ataaacagac ttcaactgat ggaaaagaga agactacttc cgctaaagag      960

acacaaagta tagagaaaac atctgctaaa gatttagcac ccacatctaa agtgctggct     1020

aaacctacac ccaaagctga aactacaacc aaaggccctg ctctcaccac tcccaaggag     1080

cccacgccca ccactcccaa ggagcctgca tctaccacac ccaaagagcc cacacctacc     1140

accatcaagt ctgcacccac cacccccaag gagcctgcac ccaccaccac caagtctgca     1200

cccaccactc ccaaggagcc tgcacccacc accaccaagg agcctgcacc caccactccc     1260

aaggagcctg cacccaccac caccaaggag cctgcaccca ccaccaccaa gtctgcaccc     1320

accactccca aggagcctgc acccaccacc cccaagaagc ctgccccaac tacccccaag     1380

gagcctgcac ccaccactcc caaggagcct acacccacca ctcccaagga gcctgcaccc     1440

accaccaagg agcctgcacc caccactccc aaagagcctg cacccactgc ccccaagaag     1500

cctgccccaa ctacccccaa ggagcctgca cccaccactc ccaaggagcc tgcacccacc     1560

accaccaagg agccttcacc caccactccc aaggagcctg cacccaccac caccaagtct     1620

gcacccacca ctaccaagga gcctgcaccc accactacca agtctgcacc caccactccc     1680

aaggagcctt cacccaccac caccaaggag cctgcaccca ccactcccaa ggagcctgca     1740

cccaccaccc ccaagaagcc tgccccaact acccccaagg agcctgcacc caccactccc     1800

aaggaacctg cacccaccac caccaagaag cctgcaccca ccgctcccaa agagcctgcc     1860

ccaactaccc ccaaggagac tgcacccacc acccccaaga agctcacgcc caccaccccc     1920

gagaagctcg cacccaccac ccctgagaag cccgcaccca ccacccctga ggagctcgca     1980

cccaccaccc ctgaggagcc cacacccacc acccctgagg agcctgctcc caccactccc     2040

aaggcagcgg ctcccaacac ccctaaggag cctgctccaa ctacccctaa ggagcctgct     2100

ccaactaccc ctaaggagcc tgctccaact acccctaagg agactgctcc aactacccct     2160

aaagggactg ctccaactac cctcaaggaa cctgcaccca ctactcccaa gaagcctgcc     2220

cccaaggagc ttgcacccac caccaccaag gagcccacat ccaccacctc tgacaagccc     2280

gctccaacta cccctaaggg gactgctcca actaccccta aggagcctgc tccaactacc     2340

cctaaggagc ctgctccaac tacccctaag gggactgctc caactaccct caaggaacct     2400

gcacccacta ctcccaagaa gcctgccccc aaggagcttg cacccaccac caccaagggg     2460

cccacatcca ccacctctga caagcctgct ccaactacac ctaaggagac tgctccaact     2520

acccccaagg agcctgcacc cactaccccc aagaagcctg ctccaactac tcctgagaca     2580

cctcctccaa ccacttcaga ggtctctact ccaactacca ccaaggagcc taccactatc     2640

cacaaaagcc ctgatgaatc aactcctgag ctttctgcag aacccacacc aaaagctctt     2700

gaaaacagtc ccaaggaacc tggtgtacct acaactaaga ctcctgcagc gactaaacct     2760

gaaatgacta caacagctaa agacaagaca acagaaagag acttacgtac tacacctgaa     2820

actacaactg ctgcacctaa gatgacaaaa gagacagcaa ctacaacaga aaaaactacc     2880

gaatccaaaa taacagctac aaccacacaa gtaacatcta ccacaactca agataccaca     2940

ccattcaaaa ttactactct taaaacaact actcttgcac ccaaagtaac tacaacaaaa     3000

aagacaatta ctaccactga gattatgaac aaacctgaag aaacagctaa accaaaagac     3060

agagctacta attctaaagc gacaactcct aaacctcaaa agccaaccaa agcacccaaa     3120

aaacccactt ctaccaaaaa gccaaaaaca atgcctagag tgagaaaacc aaagacgaca     3180

ccaactcccc gcaagatgac atcaacaatg ccagaattga accctacctc aagaatagca     3240

gaagccatgc tccaaaccac caccagacct aaccaaactc caaactccaa actagttgaa     3300

gtaaatccaa agagtgaaga tgcaggtggt gctgaaggag aaacacctca tatgcttctc     3360

aggccccatg tgttcatgcc tgaagttact cccgacatgg attacttacc gagagtaccc     3420

aatcaaggca ttatcatcaa tcccatgctt tccgatgaga ccaatatatg caatggtaag     3480

ccagtagatg gactgactac tttgcgcaat gggacattag ttgcattccg aggtcattat     3540

ttctggatgc taagtccatt cagtccacca tctccagctc gcagaattac tgaagtttgg     3600

ggtattcctt cccccattga tactgttttt actaggtgca actgtgaagg aaaaactttc     3660

ttctttaagg attctcagta ctggcgtttt accaatgata taaaagatgc agggtacccc     3720

aaaccaattt tcaaaggatt tggaggacta actggacaaa tagtggcagc gctttcaaca     3780

gctaaatata agaactggcc tgaatctgtg tattttttca agagaggtgg cagcattcag     3840

cagtatattt ataaacagga acctgtacag aagtgccctg gaagaaggcc tgctctaaat     3900

tatccagtgt atggagaaat gacacaggtt aggagacgtc gctttgaacg tgctatagga     3960

ccttctcaaa cacacaccat cagaattcaa tattcacctg ccagactggc ttatcaagac     4020

aaaggtgtcc ttcataatga agttaaagtg agtatactgt ggagaggact tccaaatgtg     4080

gttacctcag ctatatcact gcccaacatc agaaaacctg acggctatga ttactatgcc     4140

ttttctaaag atcaatacta taacattgat gtgcctagta gaacagcaag agcaattact     4200

actcgttctg ggcagacctt atccaaagtc tggtacaact gtccttagac tgatgagcaa     4260

aggaggagtc aactaatgaa gaaatgaata ataaattttg acactgaaaa acattttatt     4320

aataaagaat attgacatga gtataccagt ttatatataa aaatgttttt aaacttgaca     4380

atcattacac taaaacagat ttgataatct tattcacagt tgttattgtt tacagaccat     4440

ttaattaata tttcctctgt ttattcctcc tctccctccc attgcatggc tcacacctgt     4500

aaaagaaaaa agaatcaaat tgaatatatc ttttaagaat tcaaaactag tgtattcact     4560

taccctagtt cattataaaa aatatctagg cattgtggat ataaaactgt tgggtattct     4620

acaacttcaa tggaaattat tacaagcaga ttaatccctc tttttgtgac acaagtacaa     4680

tctaaaagtt atattggaaa acatggaaat attaaaattt tacactttta ctagctaaaa     4740

cataatcaca aagctttatc gtgttgtata aaaaaattaa caatataatg gcaataggta     4800

gagatacaac aaatgaatat aacactataa cacttcatat tttccaaatc ttaatttgga     4860

tttaaggaag aaatcaataa atataaaata taagcacata tttattatat atctaaggta     4920

tacaaatctg tctacatgaa gtttacagat tggtaaatat cacctgctca acatgtaatt     4980

atttaataaa actttggaac attaaaaaaa taaattggag gcttaaaaaa aaaaaaaaaa     5040


