                         SEQUENCE LISTING

<110>  uniQure IP B.V.
 
<120>  Treatment of neurological diseases using adeno-associated virus 
       (AAV) comprising   AAV-5 capsid proteins

<130>  P6046883EP

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  145
<212>  DNA
<213>  adeno-associated virus 2

<400>  1
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg    120

gccaactcca tcactagggg ttcct                                          145


<210>  2
<211>  183
<212>  DNA
<213>  adeno-associated virus 2

<400>  2
gcgcggtacc ccatggagga acccctagtg atggagttgg ccactccctc tctgcgcgct     60

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg    120

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca agatatccca tggggtaccg    180

cgc                                                                  183


<210>  3
<211>  2203
<212>  DNA
<213>  adeno-associated virus 5

<400>  3
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag     60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa    120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga    180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag    240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag    300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc    360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc    420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc    480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc    540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca    600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc    660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc    720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc    780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc    840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg    900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc    960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag   1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc   1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc   1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac   1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt   1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc   1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc   1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg   1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg   1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc   1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc   1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc   1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc   1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac   1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc   1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac   1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc   1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc   2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac   2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt   2160

acccgacccc tttaacccat tcatgtcgca taccctcaat aaa                     2203


<210>  4
<211>  724
<212>  PRT
<213>  adeno-associated virus 5

<400>  4

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  5
<211>  1876
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  CDS
<222>  (11)..(1876)

<400>  5
cgcagccgcc atg ccg ggg ttt tac gag att gtg att aag gtc ccc agc        49
           Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser          
           1               5                   10                       

gac ctt gac gag cat ctg ccc ggc att tct gac agc ttt gtg aac tgg       97
Asp Leu Asp Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp         
    15                  20                  25                          

gtg gcc gag aag gaa tgg gag ttg ccg cca gat tct gac atg gat ctg      145
Val Ala Glu Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu         
30                  35                  40                  45          

aat ctg att gag cag gca ccc ctg acc gtg gcc gag aag ctg cag cgc      193
Asn Leu Ile Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg         
                50                  55                  60              

gac ttt ctg acg gaa tgg cgc cgt gtg agt aag gcc ccg gag gcc ctt      241
Asp Phe Leu Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu         
            65                  70                  75                  

ttc ttt gtg caa ttt gag aag gga gag agc tac ttc cac atg cac gtg      289
Phe Phe Val Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val         
        80                  85                  90                      

ctc gtg gaa acc acc ggg gtg aaa tcc atg gtt ttg gga cgt ttc ctg      337
Leu Val Glu Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu         
    95                  100                 105                         

agt cag att cgc gaa aaa ctg att cag aga att tac cgc ggg atc gag      385
Ser Gln Ile Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu         
110                 115                 120                 125         

ccg act ttg cca aac tgg ttc gcg gtc aca aag acc aga aat ggc gcc      433
Pro Thr Leu Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala         
                130                 135                 140             

gga ggc ggg aac aag gtg gtg gat gag tgc tac atc ccc aat tac ttg      481
Gly Gly Gly Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu         
            145                 150                 155                 

ctc ccc aaa acc cag cct gag ctc cag tgg gcg tgg act aat atg gaa      529
Leu Pro Lys Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu         
        160                 165                 170                     

cag tat tta agc gcc tgt ttg aat ctc acg gag cgt aaa cgg ttg gtg      577
Gln Tyr Leu Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val         
    175                 180                 185                         

gcg cag cat ctg acg cac gtg tcg cag acg cag gag cag aac aaa gag      625
Ala Gln His Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu         
190                 195                 200                 205         

aat cag aat ccc aat tct gat gcg ccg gtg atc aga tca aaa act tca      673
Asn Gln Asn Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser         
                210                 215                 220             

gcc agg tac atg gag ctg gtc ggg tgg ctc gtg gac aag ggg att acc      721
Ala Arg Tyr Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr         
            225                 230                 235                 

tcg gag aag cag tgg atc cag gag gac cag gcc tca tac atc tcc ttc      769
Ser Glu Lys Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe         
        240                 245                 250                     

aat gcg gcc tcc aac tcg cgg tcc caa atc aag gct gcc ttg gac aat      817
Asn Ala Ala Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn         
    255                 260                 265                         

gcg gga aag att atg agc ctg act aaa acc gcc ccc gac tac ctg gtg      865
Ala Gly Lys Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val         
270                 275                 280                 285         

ggc cag cag ccc gtg gag gac att tcc agc aat cgg att tat aaa att      913
Gly Gln Gln Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile         
                290                 295                 300             

ttg gaa cta aac ggg tac gat ccc caa tat gcg gct tcc gtc ttt ctg      961
Leu Glu Leu Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu         
            305                 310                 315                 

gga tgg gcc acg aaa aag ttc ggc aag agg aac acc atc tgg ctg ttt     1009
Gly Trp Ala Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe         
        320                 325                 330                     

ggg cct gca act acc ggg aag acc aac atc gcg gag gcc ata gcc cac     1057
Gly Pro Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His         
    335                 340                 345                         

act gtg ccc ttc tac ggg tgc gta aac tgg acc aat gag aac ttt ccc     1105
Thr Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro         
350                 355                 360                 365         

ttc aac gac tgt gtc gac aag atg gtg atc tgg tgg gag gag ggg aag     1153
Phe Asn Asp Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys         
                370                 375                 380             

atg acc gcc aag gtc gtg gag tcg gcc aaa gcc att ctc gga gga agc     1201
Met Thr Ala Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser         
            385                 390                 395                 

aag gtg cgc gtg gac cag aaa tgc aag tcc tcg gcc cag ata gac ccg     1249
Lys Val Arg Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro         
        400                 405                 410                     

act ccc gtg atc gtc acc tcc aac acc aac atg tgc gcc gtg att gac     1297
Thr Pro Val Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp         
    415                 420                 425                         

ggg aac tca acg acc ttc gaa cac cag cag ccg ttg caa gac cgg atg     1345
Gly Asn Ser Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met         
430                 435                 440                 445         

ttc aaa ttt gaa ctc acc cgc cgt ctg gat cat gac ttt ggg aag gtc     1393
Phe Lys Phe Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val         
                450                 455                 460             

acc aag cag gaa gtc aaa gac ttt ttc cgg tgg gca aag gat cac gtg     1441
Thr Lys Gln Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val         
            465                 470                 475                 

gtt gag gtg gag cat gaa ttc tac gtc aaa aag ggt gga gcc aag aaa     1489
Val Glu Val Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys         
        480                 485                 490                     

aga ccc gcc ccc agt gac gca gat ata agt gag ccc aaa cgg gtg cgc     1537
Arg Pro Ala Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg         
    495                 500                 505                         

gag tca gtt gcg cag cca tcg acg tca gac gcg gaa gct tcg atc aac     1585
Glu Ser Val Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn         
510                 515                 520                 525         

tac gca gac agg tac caa aac aaa tgt tct cgt cac gtg ggc atg aat     1633
Tyr Ala Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn         
                530                 535                 540             

ctg atg ctg ttt ccc tgc aga caa tgc gag aga atg aat cag aat tca     1681
Leu Met Leu Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser         
            545                 550                 555                 

aat atc tgc ttc act cac gga cag aaa gac tgt tta gag tgc ttt ccc     1729
Asn Ile Cys Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro         
        560                 565                 570                     

gtg tca gaa tct caa ccc gtt tct gtc gtc aaa aag gcg tat cag aaa     1777
Val Ser Glu Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys         
    575                 580                 585                         

ctg tgc tac att cat cat atc atg gga aag gtg cca gac gct tgc act     1825
Leu Cys Tyr Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr         
590                 595                 600                 605         

gcc tgc gat ctg gtc aat gtg gat ttg gat gac tgc atc ttt gaa caa     1873
Ala Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln         
                610                 615                 620             

taa                                                                 1876


<210>  6
<211>  621
<212>  PRT
<213>  adeno-associated virus 2

<400>  6

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  7
<211>  1194
<212>  DNA
<213>  Artificial

<220>
<223>  AAV2 Rep52 AcMNPV optimized


<220>
<221>  misc_feature
<223>  AcMNPV optimized Rep52 coding sequence

<400>  7
atggaattgg tcggttggtt ggtggacaag ggtattacct cggagaagca atggatacaa     60

gaagatcaag cctcatacat ctcgtttaat gcggcatcca actcgcgtag ccaaatcaaa    120

gctgccttgg acaatgcggg caagattatg agcctgacta aaaccgcccc cgactacctg    180

gtgggccagc aacccgtgga agacatttcc agcaatcgca tctataagat tttggagtta    240

aacggctacg atcctcaata tgcggcttcc gtatttttgg gctgggcgac gaaaaagttt    300

ggcaaaagaa acaccatttg gttgtttgga cctgcaacta cgggaaaaac aaacatagcg    360

gaggccatag cccacactgt acctttttat ggctgcgtta actggaccaa tgagaacttt    420

ccattcaacg actgtgtcga caagatggtt atttggtggg aggaaggcaa aatgaccgct    480

aaagtcgtgg agtcggccaa agcaatttta ggaggcagca aagtgcgcgt agaccagaaa    540

tgcaaaagct ctgcgcagat agacccgaca ccggtgatcg ttacaagcaa cacgaacatg    600

tgcgccgtga ttgacggtaa cagtacgaca ttcgaacacc aacaaccgtt gcaagaccga    660

atgttcaaat ttgaattgac gcgccgactg gatcatgatt ttggcaaggt aacaaaacaa    720

gaagtcaaag acttctttcg ttgggcaaag gatcacgttg ttgaagtgga acatgaattt    780

tacgtcaaaa aaggtggtgc taagaaaaga cccgccccga gtgatgcaga tataagtgag    840

cccaaacgag tgagagaatc ggttgcgcag ccaagcacgt cagatgcgga agcttcgata    900

aactacgcag accgctacca aaacaaatgt tctcgtcacg taggcatgaa cttaatgttg    960

tttccctgca gacaatgtga gagaatgaat cagaatagta atatctgttt cactcacggc   1020

cagaaagact gtttagaatg ctttccggtg tcagaatctc aacccgtttc tgtcgtaaaa   1080

aaggcgtatc aaaaattatg ctatattcat catatcatgg gaaaagtgcc agacgcttgt   1140

actgcctgcg atctggttaa tgtggatttg gatgactgta tctttgaaca ataa         1194


