                         SEQUENCE LISTING

<110>  OPKO BIOLOGICS LTD.
       FARES, Fuad
       FIMA, Udi Eyal
 
<120>  LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND 
       ADMINISTERING SAME

<130>  P-9520-PC6

<150>  14/059,134
<151>  2013-10-21

<150>  14/309,496
<151>  2014-06-19

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
        195                 200                 205             


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
    210                 215                 220     


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
        195                 200                 205             


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser 
    210                 215                 220                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
225                 230                 235                 240 


Pro Ser Asp Thr Pro Ile Leu Pro Gln 
                245                 


<210>  3
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ser Ser Ser Ser Lys 
            20                  25                  30          


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
        35                  40                  45              


Asp Thr Pro Ile Leu Pro Gln Ala Pro Pro Arg Leu Ile Cys Asp Ser 
    50                  55                  60                  


Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu Ala Glu Asn Ile 
65                  70                  75                  80  


Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val 
                85                  90                  95      


Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly 
            100                 105                 110         


Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala 
        115                 120                 125             


Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu 
    130                 135                 140                 


Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro 
                165                 170                 175     


Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr 
            180                 185                 190         


Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu 
        195                 200                 205             


Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg Ser Ser Ser 
    210                 215                 220                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
225                 230                 235                 240 


Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro 
                245                 250                 255     


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
            260                 265                 270         


Pro Ile Leu Pro Gln 
        275         


<210>  4
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
        195                 200                 205             


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ala Pro Pro 
    210                 215                 220                 


Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala 
225                 230                 235                 240 


Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu 
                245                 250                 255     


Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp 
            260                 265                 270         


Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu 
        275                 280                 285             


Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn 
    290                 295                 300                 


Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val 
305                 310                 315                 320 


Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln 
                325                 330                 335     


Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg 
            340                 345                 350         


Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn 
        355                 360                 365             


Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr 
    370                 375                 380                 


Gly Asp Arg 
385         


<210>  5
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ser Ser Ser Ser Lys 
            20                  25                  30          


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
        35                  40                  45              


Asp Thr Pro Ile Leu Pro Gln Ala Pro Pro Arg Leu Ile Cys Asp Ser 
    50                  55                  60                  


Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu Ala Glu Asn Ile 
65                  70                  75                  80  


Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val 
                85                  90                  95      


Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly 
            100                 105                 110         


Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala 
        115                 120                 125             


Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu 
    130                 135                 140                 


Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro 
                165                 170                 175     


Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr 
            180                 185                 190         


Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu 
        195                 200                 205             


Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    210                 215                 220     


<210>  6
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ser Ser Ser Ser Lys 
            20                  25                  30          


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
        35                  40                  45              


Asp Thr Pro Ile Leu Pro Gln Ala Pro Pro Arg Leu Ile Cys Asp Ser 
    50                  55                  60                  


Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu Ala Glu Asn Ile 
65                  70                  75                  80  


Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val 
                85                  90                  95      


Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly 
            100                 105                 110         


Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala 
        115                 120                 125             


Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu 
    130                 135                 140                 


Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu 
145                 150                 155                 160 


Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro 
                165                 170                 175     


Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr 
            180                 185                 190         


Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu 
        195                 200                 205             


Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg Ser Ser Ser 
    210                 215                 220                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
225                 230                 235                 240 


Pro Ser Asp Thr Pro Ile Leu Pro Gln 
                245                 


<210>  7
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for EPO-CTP constructs

<400>  7
aatctagagg tcatcatggg ggtgc                                             25


<210>  8
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for EPO-CTP constructs

<400>  8
attgcggccg cggatccaga agacctttat tg                                     32


<210>  9
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for EPO-CTP constructs

<400>  9
taaatattgg ggtgtccgag ggccc                                             25


<210>  10
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for EPO-CTP constructs

<400>  10
ccaatattac cacaagcccc accacgcctc at                                     32


<210>  11
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for EPO-CTP constructs

<400>  11
tgcggccgcg gatccttatc tgtcccctgt cctgc                                  35


<210>  12
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for EPO-CTP constructs

<400>  12
gccctgctgt cggaagc                                                      17


<210>  13
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for EPO-CTP constructs

<400>  13
attgcggccg cggatccaga agacctttat tg                                     32


<210>  14
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for EPO-CTP constructs

<400>  14
ctttgaggaa gaggagccca ggactgggag gc                                     32


<210>  15
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for EPO-CTP constructs

<400>  15
cctgggctcc tcttcctcaa aggc                                              24


<210>  16
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  17
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  CTP amino acid sequence

<400>  17

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


Pro Gln 
        


<210>  18
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  CTP amino acid sequence

<400>  18

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  19
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly 
            20                  25          


<210>  20
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  20
tctagaggtc atcatggggg tgcacgaatg tcctgcctgg ctgtggcttc tcctgtccct       60

tctgtcgctc cctctgggcc tcccagtcct gggctcctct tcctcaaagg cccctccccc      120

gagccttcca agtccatccc gactcccggg gccctcggac accccaatat taccacaagc      180

cccaccacgc ctcatctgtg acagccgagt cctggagagg tacctcttgg aggccaagga      240

ggccgagaat atcacgacgg gctgtgctga acactgcagc ttgaatgaga atatcactgt      300

cccagacacc aaagttaatt tctatgcctg gaagaggatg gaggtcgggc agcaggccgt      360

agaagtctgg cagggcctgg ccctgctgtc ggaagctgtc ctgcggggcc aggccctgtt      420

ggtcaactct tcccagccgt gggagcccct gcagctgcat gtggataaag ccgtcagtgg      480

ccttcgcagc ctcaccactc tgcttcgggc tctgggagcc cagaaggaag ccatctcccc      540

tccagatgcg gcctcagctg ctccactccg aacaatcact gctgacactt tccgcaaact      600

cttccgagtc tactccaatt tcctccgggg aaagctgaag ctgtacacag gggaggcctg      660

caggacaggg gacagatcct cttcctcaaa ggcccctccc ccgagccttc caagtccatc      720

ccgactcccg gggccctcgg acaccccgat cctcccacaa taaaggtctt ctggatccgc      780

ggccgc                                                                 786


<210>  21
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  21
tctagaggtc atcatggggg tgcacgaatg tcctgcctgg ctgtggcttc tcctgtccct       60

tctgtcgctc cctctgggcc tcccagtcct gggctcctct tcctcaaagg cccctccccc      120

gagccttcca agtccatccc gactcccggg gccctcggac accccaatat taccacaagc      180

cccaccacgc ctcatctgtg acagccgagt cctggagagg tacctcttgg aggccaagga      240

ggccgagaat atcacgacgg gctgtgctga acactgcagc ttgaatgaga atatcactgt      300

cccagacacc aaagttaatt tctatgcctg gaagaggatg gaggtcgggc agcaggccgt      360

agaagtctgg cagggcctgg ccctgctgtc ggaagctgtc ctgcggggcc aggccctgtt      420

ggtcaactct tcccagccgt gggagcccct gcagctgcat gtggataaag ccgtcagtgg      480

ccttcgcagc ctcaccactc tgcttcgggc tctgggagcc cagaaggaag ccatctcccc      540

tccagatgcg gcctcagctg ctccactccg aacaatcact gctgacactt tccgcaaact      600

cttccgagtc tactccaatt tcctccgggg aaagctgaag ctgtacacag gggaggcctg      660

caggacaggg gacagatcct cttcctcaaa ggcccctccc ccgagccttc caagtccatc      720

ccgactcccg gggccctccg acacaccaat cctgccacag agcagctcct ctaaggcccc      780

tcctccatcc ctgccatccc cctcccggct gcctggcccc tctgacaccc ctatcctgcc      840

tcagtgatga aggtcttctg gatccgcggc cgc                                   873


<210>  22
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Ser Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
        195                 200                 205             


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
    210                 215                 220     


<210>  23
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Val Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  24
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Ser Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  25
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  25

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  26
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser 
            20      


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  XbaI Forward primer for HGH-CTP constructs

<400>  27
ctctagagga catggccac                                                    19


<210>  28
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for HGH-CTP constructs

<400>  28
acagggaggt ctgggggttc tgca                                              24


<210>  29
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for HGH-CTP constructs

<400>  29
tgcagaaccc ccagacctcc ctgtgc                                            26


<210>  30
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for HGH-CTP constructs

<400>  30
ccaaactcat caatgtatct ta                                                22


<210>  31
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  XbaI Forward primer for HGH-CTP constructs

<400>  31
ctctagagga catggccac                                                    19


<210>  32
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for HGH-CTP constructs

<400>  32
cgaactcctg gtaggtgtca aaggc                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for HGH-CTP constructs

<400>  33
gcctttgaca cctaccagga gttcg                                             25


<210>  34
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  NotI Reverse primer for HGH-CTP constructs

<400>  34
acgcggccgc atccagacct tcatcactga ggc                                    33


<210>  35
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for HGH-CTP constructs

<400>  35
gcggccgcgg actcatcaga agccgcagct gccc                                   34


<210>  36
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  37
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Ser Ser Ser Lys Ala Pro 
    210                 215                 220                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
225                 230                 235                 240 


Pro Ile Leu Pro Gln 
                245 


<210>  38
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Ser Ser Ser Lys Ala Pro 
    210                 215                 220                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
225                 230                 235                 240 


Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
                245                 250                 255     


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
            260                 265                 270         


Gln 
    


<210>  39
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Ser Ser Ser Lys Ala 
            20                  25                  30          


Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp 
        35                  40                  45              


Thr Pro Ile Leu Pro Gln Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
    50                  55                  60                  


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
65                  70                  75                  80  


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
                85                  90                  95      


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
            100                 105                 110         


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
        115                 120                 125             


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
    130                 135                 140                 


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
145                 150                 155                 160 


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
                165                 170                 175     


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
            180                 185                 190         


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
        195                 200                 205             


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
    210                 215                 220                 


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
225                 230                 235                 240 


Gly Ser Cys Gly Phe Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
                245                 250                 255     


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
            260                 265                 270         


Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
        275                 280                 285             


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
    290                 295                 300     


<210>  40
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Ser Ser Ser Lys Ala 
            20                  25                  30          


Pro Pro Pro Ser Leu Pro Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
        35                  40                  45              


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
    50                  55                  60                  


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
65                  70                  75                  80  


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
                85                  90                  95      


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
            100                 105                 110         


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
        115                 120                 125             


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
    130                 135                 140                 


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
145                 150                 155                 160 


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
                165                 170                 175     


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
            180                 185                 190         


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
        195                 200                 205             


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
    210                 215                 220                 


Gly Ser Cys Gly Phe Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
225                 230                 235                 240 


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
                245                 250                 255     


Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
            260                 265                 270         


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
        275                 280                 285 


<210>  41
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Ser Ser Ser Lys Ala 
            20                  25                  30          


Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp 
        35                  40                  45              


Thr Pro Ile Leu Pro Gln Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
    50                  55                  60                  


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
65                  70                  75                  80  


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
                85                  90                  95      


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
            100                 105                 110         


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
        115                 120                 125             


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
    130                 135                 140                 


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
145                 150                 155                 160 


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
                165                 170                 175     


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
            180                 185                 190         


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
        195                 200                 205             


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
    210                 215                 220                 


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
225                 230                 235                 240 


Gly Ser Cys Gly Phe Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
                245                 250                 255     


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
            260                 265                 270         


Gln 
    


<210>  42
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Ser Ser Ser Lys Ala 
            20                  25                  30          


Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp 
        35                  40                  45              


Thr Pro Ile Leu Pro Gln Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
    50                  55                  60                  


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
65                  70                  75                  80  


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
                85                  90                  95      


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
            100                 105                 110         


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
        115                 120                 125             


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
    130                 135                 140                 


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
145                 150                 155                 160 


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
                165                 170                 175     


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
            180                 185                 190         


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
        195                 200                 205             


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
    210                 215                 220                 


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
225                 230                 235                 240 


Gly Ser Cys Gly Phe 
                245 


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CTP amino acid sequence

<400>  43

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro 
1               5                   10          


<210>  44
<211>  853
<212>  DNA
<213>  Homo sapiens

<400>  44
tctagaggac atggccaccg gcagcaggac cagcctgctg ctggccttcg gcctgctgtg       60

cctgccatgg ctgcaggagg gcagcgccag ctcttcttct aaggctccac ccccatctct      120

gcccagcccc agcagactgc cgggccccag cgacacaccc attctgcccc agttccccac      180

catccccctg agcaggctgt tcgacaacgc catgctgagg gctcacaggc tgcaccagct      240

ggcctttgac acctaccagg agttcgagga agcctacatc cccaaggagc agaagtacag      300

cttcctgcag aacccccaga cctccctgtg cttcagcgag agcatcccca cccccagcaa      360

cagagaggag acccagcaga agagcaacct ggagctgctg aggatctccc tgctgctgat      420

ccagagctgg ctggagcccg tgcagttcct gagaagcgtg ttcgccaaca gcctggtgta      480

cggcgccagc gacagcaacg tgtacgacct gctgaaggac ctggaggagg gcatccagac      540

cctgatgggc cggctggagg acggcagccc caggaccggc cagatcttca agcagaccta      600

cagcaagttc gacaccaaca gccacaacga cgacgccctg ctgaagaact acgggctgct      660

gtactgcttc agaaaggaca tggacaaggt ggagaccttc ctgaggatcg tgcagtgcag      720

aagcgtggag ggcagctgcg gcttcagctc cagcagcaag gcccctcccc cgagcctgcc      780

ctccccaagc aggctgcctg ggccctccga cacaccaatc ctgcctcagt gatgaaggtc      840

tggatgcggc cgc                                                         853


<210>  45
<211>  937
<212>  DNA
<213>  Homo sapiens

<400>  45
tctagaggac atggccaccg gcagcaggac cagcctgctg ctggccttcg gcctgctgtg       60

cctgccatgg ctgcaggagg gcagcgccag ctcttcttct aaggctccac ccccatctct      120

gcccagcccc agcagactgc cgggccccag cgacacaccc attctgcccc agttccccac      180

catccccctg agcaggctgt tcgacaacgc catgctgagg gctcacaggc tgcaccagct      240

ggcctttgac acctaccagg agttcgagga agcctacatc cccaaggagc agaagtacag      300

cttcctgcag aacccccaga cctccctgtg cttcagcgag agcatcccca cccccagcaa      360

cagagaggag acccagcaga agagcaacct ggagctgctg aggatctccc tgctgctgat      420

ccagagctgg ctggagcccg tgcagttcct gagaagcgtg ttcgccaaca gcctggtgta      480

cggcgccagc gacagcaacg tgtacgacct gctgaaggac ctggaggagg gcatccagac      540

cctgatgggc cggctggagg acggcagccc caggaccggc cagatcttca agcagaccta      600

cagcaagttc gacaccaaca gccacaacga cgacgccctg ctgaagaact acgggctgct      660

gtactgcttc agaaaggaca tggacaaggt ggagaccttc ctgaggatcg tgcagtgcag      720

aagcgtggag ggcagctgcg gcttcagctc cagcagcaag gcccctcccc cgagcctgcc      780

ctccccaagc aggctgcctg ggccctccga cacaccaatc ctgccacaga gcagctcctc      840

taaggcccct cctccatccc tgccatcccc ctcccggctg cctggcccct ctgacacccc      900

tatcctgcct cagtgatgaa ggtctggatg cggccgc                               937


<210>  46
<211>  889
<212>  DNA
<213>  Homo sapiens

<400>  46
tctagaggac atggccaccg gcagcaggac cagcctgctg ctggccttcg gcctgctgtg       60

cctgccatgg ctgcaggagg gcagcgccag ctcttcttct aaggctccac ccccgagcct      120

gcccttcccc accatccccc tgagcaggct gttcgacaac gccatgctga gggctcacag      180

gctgcaccag ctggcctttg acacctacca ggagttcgag gaagcctaca tccccaagga      240

gcagaagtac agcttcctgc agaaccccca gacctccctg tgcttcagcg agagcatccc      300

cacccccagc aacagagagg agacccagca gaagagcaac ctggagctgc tgaggatctc      360

cctgctgctg atccagagct ggctggagcc cgtgcagttc ctgagaagcg tgttcgccaa      420

cagcctggtg tacggcgcca gcgacagcaa cgtgtacgac ctgctgaagg acctggagga      480

gggcatccag accctgatgg gccggctgga ggacggcagc cccaggaccg gccagatctt      540

caagcagacc tacagcaagt tcgacaccaa cagccacaac gacgacgccc tgctgaagaa      600

ctacgggctg ctgtactgct tcagaaagga catggacaag gtggagacct tcctgaggat      660

cgtgcagtgc agaagcgtgg agggcagctg cggcttcagc tccagcagca aggcccctcc      720

cccgagcctg ccctccccaa gcaggctgcc tgggccctcc gacacaccaa tcctgccaca      780

gagcagctcc tctaaggccc ctcctccatc cctgccatcc ccctcccggc tgcctggccc      840

ctctgacacc cctatcctgc ctcagtgatg aaggtctgga tgcggccgc                  889


<210>  47
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  48
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


Gln 
    


<210>  49
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala 
            20                  25      


<210>  50
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for EPO-CTP constructs

<400>  50
gcttccgaca gcagggc                                                      17


