                         SEQUENCE LISTING

<110>  The Centre for Drug Research and Development
       University of British Columbia
 
<120>  ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME

<130>  V88220WO

<140>  PCT/CA2014/051020
<141>  2014-10-21

<150>  61/893,817
<151>  2013-10-21

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Leu Glu Thr Val Phe 
225                 230                 235                 240 


His His Val Ser Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
                245                 250                 255     


Pro Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Ala Ser Ser Val Ile 
            260                 265                 270         


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
        275                 280                 285             


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
    290                 295                 300                 


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
305                 310                 315                 320 


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
                325                 330                 335     


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
            340                 345                 350         


Ser Glu Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala 
        355                 360                 365             


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
    370                 375                 380                 


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
385                 390                 395                 400 


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
                405                 410                 415     


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
            420                 425                 430         


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
        435                 440                 445             


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
    450                 455                 460                 


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
465                 470                 475                 480 


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
                485                 490                 495     


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
            500                 505                 510         


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
        515                 520                 525             


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
    530                 535                 540                 


Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
545                 550                 555             


<210>  2
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence for the heavy chain variable region

       anti-podocalyxin antibody

<400>  2
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggcgg agtccggggg tcgcctggtc acgcctggca cacccctgac actcacctgc      120

acagcctctg gaatcgacct cagtagctat gcaatgggct gggtccgcca ggctccaggg      180

aaggggctgg aatacatcgg attcatttat gctagtggca gtatattcta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agcctgacaa ccgaggacac ggccacctat ttctgtgcca gagcgggata ttattttggt      360

ggtaattatg atcttaactt gtggggccaa ggcaccctgg tcaccgtctc ttca            414


<210>  3
<211>  138
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for the heavy chain variable region

       anti-podocalyxin antibody

<400>  3

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Ala Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Tyr Ile Gly Phe Ile Tyr Ala Ser Gly Ser Ile Phe Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Ala Gly Tyr Tyr Phe Gly Gly Asn Tyr Asp Leu Asn Leu Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135             


<210>  4
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid sequence for the light chain variable region 

       anti-podocalyxin antibody

<400>  4
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgctg acattgtgct gacccagact ccagcctcgg tggaggtagc tgtgggaggc      120

acagtcacca tcaagtgcca ggccagtcag agcattagta attacttagc ctggtatcag      180

cggaaaccag ggcagcctcc caggctcctg atctacaggg catccactct ggcatctggg      240

gtctcatcgc ggttcaaagg cagtggatct gggacacagt tcactctcac catcagcggc      300

gtggagtgtg ccgatgctgc cacttactac tgtcaacagg gttatgtcag taataatctt      360

gataatattt tcggcggagg gaccgaggtg gtggtcaaa                             399


<210>  5
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for the light chain variable region

       anti-podocalyxin antibody

<400>  5

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ile Val Leu Thr Gln Thr Pro Ala 
            20                  25                  30          


Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
        35                  40                  45              


Ser Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Arg Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Arg Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly 
65                  70                  75                  80  


Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Tyr Val Ser Asn Asn Leu Asp Asn Ile Phe Gly Gly Gly Thr 
        115                 120                 125             


Glu Val Val Val Lys 
    130             


<210>  6
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR1

<400>  6

Ser Tyr Ala Met Gly 
1               5   


<210>  7
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1) 

VH CDR2

<400>  7

Phe Ile Tyr Ala Ser Gly Ser Ile Phe Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1) 

VH CDR3

<400>  8

Ala Gly Tyr Tyr Phe Gly Gly Asn Tyr Asp Leu Asn Leu 
1               5                   10              


<210>  9
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1) 

Vk CDR1

<400>  9

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

Vk CDR2

<400>  10

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  11
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

Vk CDR3

<400>  11

Gln Gln Gly Tyr Val Ser Asn Asn Leu Asp Asn Ile 
1               5                   10          


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR1

<400>  12

Gly Ile Asp Leu Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR1

<400>  13

Gly Ile Asp Leu Ser Ser Tyr Ala 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR2

<400>  14

Phe Ile Tyr Ala Ser Gly Ser Ile 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR2

<400>  15

Ile Tyr Ala Ser Gly Ser Ile 
1               5           


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

VH CDR3

<400>  16

Ala Arg Ala Gly Tyr Tyr Phe Gly Gly Asn Tyr Asp Leu Asn Leu 
1               5                   10                  15  


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

Vk CDR1

<400>  17

Gln Ser Ile Ser Asn Tyr 
1               5       


<210>  18
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 83 (Ab-1)

Vk CDR2

<400>  18

Arg Ala Ser 
1           


<210>  19
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR1

<400>  19

Ser Tyr Val Met His 
1               5   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR1

<400>  20

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR1

<400>  21

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  22
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR2

<400>  22

Tyr Ile His Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR2

<400>  23

Tyr Ile His Pro Tyr Asn Asp Gly Thr 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR2

<400>  24

Ile His Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR3

<400>  25

Ser Trp Asp Trp Tyr Phe Asp Val 
1               5               


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

VH CDR3

<400>  26

Ala Arg Ser Trp Asp Trp Tyr Phe Asp Val 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

Vk CDR1

<400>  27

Ser Ala Asn Ser Asn Val Arg Tyr Ile His 
1               5                   10  


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

Vk CDR1

<400>  28

Ser Asn Val Arg Tyr 
1               5   


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

Vk CDR2

<400>  29

Asp Thr Ser Lys Leu Ser Ser 
1               5           


<210>  30
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

Vk CDR2

<400>  30

Asp Thr Ser 
1           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Podocalyxin Antibody 3G2

Vk CDR3

<400>  31

Gln Gln Trp Ile Ser Asn Pro Leu Thr 
1               5                   


<210>  32
<211>  452
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized light chain variable nucleotide sequence 
       Podo_83_humanized_light_ver_1_nucleotide_sequence

<400>  32
tttaaacgga tctctagcga attcgccacc atggacatgc gcgtgccagc gcagctgctg       60

ggcctgctcc tcctgtggct cccagacacc cgttgcgaca ttcaaatgac ccagtcccca      120

tccagtctga gtgcgtctgt cggcgatagg gtcaccatca catgtcaggc ttcccagtcc      180

atttccaatt atctcgcttg gtaccagcag aagcctggaa aggtgcccaa actgttgatc      240

taccgcgctt ccactctcgc tagtggcgtg ccctcccggt ttagcggcag cggaagcggc      300

acagatttca ctctgactat ctcctccctg cagcctgagg acgtggctac ctactattgc      360

caacagggct acgtgtctaa taacctggac aatatctttg gaggcgggac cgaggtcgtg      420

gtcaagcgta cggtggctgc accatctgtc tt                                    452


<210>  33
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized light chain variable amino acid sequence 
       Podo_83_humanized_light_ver_1_amino_acid_sequence

<400>  33

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Val Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Tyr Val Ser Asn Asn Leu Asp Asn Ile Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys 
    130         


<210>  34
<211>  480
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized heavy chain variable nucleotide sequence

       Podo_83_humanized_ver_1_nucleotide_sequence

<400>  34
aagtttaaac ggatctctag cgaattcgcc accatggagt ttggtttgtc ctgggtgttc       60

ctggtggcaa tcctcaaagg ggtgcaatgc gaggtccagc tggtggagag cgggggcgga      120

ctggtgcagc ctggagggtc cttgaggctg agctgtgctg cctctggcat tgatctgtcc      180

tcttatgcca tgggttgggt ccgccaggcc cccggcaagg gtctcgagtg ggtgagcttt      240

atttacgcct ctggctccat cttctacgca tcttgggcga aggggcgctt caccatcagt      300

agggacaact ctaagaatac cttgtatctg cagatgaact ccctgcgggc cgaagatacc      360

gctgtgtatt actgcgcccg ggcaggctac tatttcggcg gaaattacga tctcaatctc      420

tggggccagg gcacactggt gaccgtgtcc tctgctagca ccaagggccc atcggtcttc      480


<210>  35
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized heavy chain variable amino acid sequence

       Podo_83_humanized_ver_1_amino_acid_sequence

<400>  35

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu 
        35                  40                  45              


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Phe Ile Tyr Ala Ser Gly Ser Ile Phe Tyr Ala Ser 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Ala Gly Tyr Tyr Phe Gly Gly Asn Tyr Asp Leu Asn 
        115                 120                 125             


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140 


<210>  36
<211>  477
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized heavy chain variable nucleotide sequence

       Podo_83_humanized_ver_2_nucleotide_sequence

<400>  36
aagtttaaac ggatctctag cgaattcgcc accatggagt ttggtttgtc ctgggtgttc       60

ctggtggcaa tcctcaaagg ggtgcaatgc gaggtccagc tggtggagag cgggggcgga      120

ctggtgcagc ctggagggtc cttgaggctg agctgtgctg cctctggcat tgatctgtcc      180

tcttatgcca tgggttgggt ccgccaggcc cccggcaagg gtctcgagtg ggtgagcttt      240

atttacgcct ctggctccat cttctacgca tcttgggcga aggggcgctt caccatcagt      300

agggacaact ctaatacctt gtatctgcag atgaactccc tgcgggccga agataccgct      360

gtgtattact gcgcccgggc aggctactat ttcggcggaa attacgatct caatctctgg      420

ggccagggca cactggtgac cgtgtcctct gctagcacca agggcccatc ggtcttc         477


<210>  37
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized heavy chain variable amino acid sequence

       Podo_83_humanized_ver_2_amino_acid_sequence

<400>  37

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu 
        35                  40                  45              


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Phe Ile Tyr Ala Ser Gly Ser Ile Phe Tyr Ala Ser 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Ala Gly Tyr Tyr Phe Gly Gly Asn Tyr Asp Leu Asn Leu 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 


<210>  38
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VH nucleotide sequence

mPodo_3G2_vH_NT

<400>  38
atgggatgga gctggatctt tctcctgtca ggaactgcag gtgtccactc tgaggtccag       60

ctgcagcagt ctggacctga actggtaaag cctggggctt cagtgaagat gtcctgcaag      120

gcttctggat acacattcac tagctatgtt atgcactggg tgaagcagaa gcctgggcag      180

ggccttgagt ggattggata tattcatcct tacaatgatg gtactaatta caatgagaag      240

ttcaaaggca aggccacact gacttcagac aaatcgtcca acacagccta catggaactc      300

agcagcctga cctctgagga ctctgcggtc tattactgtg caagatcatg ggactggtac      360

ttcgatgtct ggggcgcagg gaccacggtc accgtctcct ca                         402


<210>  39
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH amino acid sequence

mPodo_3G2_vH_AA

<400>  39

Met Gly Trp Ser Trp Ile Phe Leu Leu Ser Gly Thr Ala Gly Val His 
1               5                   10                  15      


Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        35                  40                  45              


Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Tyr Ile His Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala 
                85                  90                  95      


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Ser Trp Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser 
    130                 


<210>  40
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vk nucleotide sequence 

mPodo_3G2_vk_NT

<400>  40
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatatcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc caactcaaat gtaagataca ttcactggca ccagcagaag      180

tcaggcacct cccccaaaag atggatttat gacacatcca aactgtcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag caacatggag      300

gctgaagatg ctgccactta ttactgccag cagtggatta gtaacccact cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  41
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vk amino acid sequence

mPodo_3G2_vk_AA

<400>  41

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Asn 
        35                  40                  45              


Ser Asn Val Arg Tyr Ile His Trp His Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ser Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ile Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  42
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Pro Ser Ser Val Ile 
225                 230                 235                 240 


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
                245                 250                 255     


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
            260                 265                 270         


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
        275                 280                 285             


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
    290                 295                 300                 


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
305                 310                 315                 320 


Ser Glu Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala 
                325                 330                 335     


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
            340                 345                 350         


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
        355                 360                 365             


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
    370                 375                 380                 


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
385                 390                 395                 400 


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
                405                 410                 415     


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
            420                 425                 430         


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
        435                 440                 445             


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
    450                 455                 460                 


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
465                 470                 475                 480 


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
                485                 490                 495     


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
            500                 505                 510         


Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
        515                 520                 525     


