                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Vaults Engineered for Hydrophobic Drug Delivery

<130>  034044.142WO1

<150>  US 61/892,951
<151>  2013-10-18

<150>  US 61/939,130
<151>  2014-02-12

<150>  US 62/028,247
<151>  2014-06-23

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  1
tgcacacaac actggcagga tgctgtgcct tggacagaac tcctcagtct acagacagag       60

gatggcttct ggaaacttac accagaactg ggacttatat taaatcttaa tacaaatggt      120

ttgcacagct ttcttaaaca aaaaggcatt caatctctag gtgtaaaagg aagagaatgt      180

ctcctggacc taattgccac aatgctggta ctacagttta ttcgcaccag gttggaaaaa      240

gagggaatag tgttcaaatc actgatgaaa atggatgacc cttctatttc caggaatatt      300

ccctgggctt ttgaggcaat aaagcaagca agtgaatggg taagaagaac tgaaggacag      360

tacccatcta tctgcccacg gcttgaactg gggaacgact gggactctgc caccaagcag      420

ttgctgggac tccagcccat aagcactgtg tcccctcttc atagagtcct ccattacagt      480

caaggctaa                                                              489


<210>  2
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Thr Gln His Trp Gln Asp Ala Val Pro Trp Thr Glu Leu Leu Ser 
1               5                   10                  15      


Leu Gln Thr Glu Asp Gly Phe Trp Lys Leu Thr Pro Glu Leu Gly Leu 
            20                  25                  30          


Ile Leu Asn Leu Asn Thr Asn Gly Leu His Ser Phe Leu Lys Gln Lys 
        35                  40                  45              


Gly Ile Gln Ser Leu Gly Val Lys Gly Arg Glu Cys Leu Leu Asp Leu 
    50                  55                  60                  


Ile Ala Thr Met Leu Val Leu Gln Phe Ile Arg Thr Arg Leu Glu Lys 
65                  70                  75                  80  


Glu Gly Ile Val Phe Lys Ser Leu Met Lys Met Asp Asp Pro Ser Ile 
                85                  90                  95      


Ser Arg Asn Ile Pro Trp Ala Phe Glu Ala Ile Lys Gln Ala Ser Glu 
            100                 105                 110         


Trp Val Arg Arg Thr Glu Gly Gln Tyr Pro Ser Ile Cys Pro Arg Leu 
        115                 120                 125             


Glu Leu Gly Asn Asp Trp Asp Ser Ala Thr Lys Gln Leu Leu Gly Leu 
    130                 135                 140                 


Gln Pro Ile Ser Thr Val Ser Pro Leu His Arg Val Leu His Tyr Ser 
145                 150                 155                 160 


Gln Gly 
        


<210>  3
<211>  1724
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Met Gly Ile Phe Ala Asn Cys Ile Phe Cys Leu Lys Val Lys 
1               5                   10                  15      


Tyr Leu Pro Gln Gln Gln Lys Lys Lys Leu Gln Thr Asp Ile Lys Glu 
            20                  25                  30          


Asn Gly Gly Lys Phe Ser Phe Ser Leu Asn Pro Gln Cys Thr His Ile 
        35                  40                  45              


Ile Leu Asp Asn Ala Asp Val Leu Ser Gln Tyr Gln Leu Asn Ser Ile 
    50                  55                  60                  


Gln Lys Asn His Val His Ile Ala Asn Pro Asp Phe Ile Trp Lys Ser 
65                  70                  75                  80  


Ile Arg Glu Lys Arg Leu Leu Asp Val Lys Asn Tyr Asp Pro Tyr Lys 
                85                  90                  95      


Pro Leu Asp Ile Thr Pro Pro Pro Asp Gln Lys Ala Ser Ser Ser Glu 
            100                 105                 110         


Val Lys Thr Glu Gly Leu Cys Pro Asp Ser Ala Thr Glu Glu Glu Asp 
        115                 120                 125             


Thr Val Glu Leu Thr Glu Phe Gly Met Gln Asn Val Glu Ile Pro His 
    130                 135                 140                 


Leu Pro Gln Asp Phe Glu Val Ala Lys Tyr Asn Thr Leu Glu Lys Val 
145                 150                 155                 160 


Gly Met Glu Gly Gly Gln Glu Ala Val Val Val Glu Leu Gln Cys Ser 
                165                 170                 175     


Arg Asp Ser Arg Asp Cys Pro Phe Leu Ile Ser Ser His Phe Leu Leu 
            180                 185                 190         


Asp Asp Gly Met Glu Thr Arg Arg Gln Phe Ala Ile Lys Lys Thr Ser 
        195                 200                 205             


Glu Asp Ala Ser Glu Tyr Phe Glu Asn Tyr Ile Glu Glu Leu Lys Lys 
    210                 215                 220                 


Gln Gly Phe Leu Leu Arg Glu His Phe Thr Pro Glu Ala Thr Gln Leu 
225                 230                 235                 240 


Ala Ser Glu Gln Leu Gln Ala Leu Leu Leu Glu Glu Val Met Asn Ser 
                245                 250                 255     


Ser Thr Leu Ser Gln Glu Val Ser Asp Leu Val Glu Met Ile Trp Ala 
            260                 265                 270         


Glu Ala Leu Gly His Leu Glu His Met Leu Leu Lys Pro Val Asn Arg 
        275                 280                 285             


Ile Ser Leu Asn Asp Val Ser Lys Ala Glu Gly Ile Leu Leu Leu Val 
    290                 295                 300                 


Lys Ala Ala Leu Lys Asn Gly Glu Thr Ala Glu Gln Leu Gln Lys Met 
305                 310                 315                 320 


Met Thr Glu Phe Tyr Arg Leu Ile Pro His Lys Gly Thr Met Pro Lys 
                325                 330                 335     


Glu Val Asn Leu Gly Leu Leu Ala Lys Lys Ala Asp Leu Cys Gln Leu 
            340                 345                 350         


Ile Arg Asp Met Val Asn Val Cys Glu Thr Asn Leu Ser Lys Pro Asn 
        355                 360                 365             


Pro Pro Ser Leu Ala Lys Tyr Arg Ala Leu Arg Cys Lys Ile Glu His 
    370                 375                 380                 


Val Glu Gln Asn Thr Glu Glu Phe Leu Arg Val Arg Lys Glu Val Leu 
385                 390                 395                 400 


Gln Asn His His Ser Lys Ser Pro Val Asp Val Leu Gln Ile Phe Arg 
                405                 410                 415     


Val Gly Arg Val Asn Glu Thr Thr Glu Phe Leu Ser Lys Leu Gly Asn 
            420                 425                 430         


Val Arg Pro Leu Leu His Gly Ser Pro Val Gln Asn Ile Val Gly Ile 
        435                 440                 445             


Leu Cys Arg Gly Leu Leu Leu Pro Lys Val Val Glu Asp Arg Gly Val 
    450                 455                 460                 


Gln Arg Thr Asp Val Gly Asn Leu Gly Ser Gly Ile Tyr Phe Ser Asp 
465                 470                 475                 480 


Ser Leu Ser Thr Ser Ile Lys Tyr Ser His Pro Gly Glu Thr Asp Gly 
                485                 490                 495     


Thr Arg Leu Leu Leu Ile Cys Asp Val Ala Leu Gly Lys Cys Met Asp 
            500                 505                 510         


Leu His Glu Lys Asp Phe Pro Leu Thr Glu Ala Pro Pro Gly Tyr Asp 
        515                 520                 525             


Ser Val His Gly Val Ser Gln Thr Ala Ser Val Thr Thr Asp Phe Glu 
    530                 535                 540                 


Asp Asp Glu Phe Val Val Tyr Lys Thr Asn Gln Val Lys Met Lys Tyr 
545                 550                 555                 560 


Ile Ile Lys Phe Ser Met Pro Gly Asp Gln Ile Lys Asp Phe His Pro 
                565                 570                 575     


Ser Asp His Thr Glu Leu Glu Glu Tyr Arg Pro Glu Phe Ser Asn Phe 
            580                 585                 590         


Ser Lys Val Glu Asp Tyr Gln Leu Pro Asp Ala Lys Thr Ser Ser Ser 
        595                 600                 605             


Thr Lys Ala Gly Leu Gln Asp Ala Ser Gly Asn Leu Val Pro Leu Glu 
    610                 615                 620                 


Asp Val His Ile Lys Gly Arg Ile Ile Asp Thr Val Ala Gln Val Ile 
625                 630                 635                 640 


Val Phe Gln Thr Tyr Thr Asn Lys Ser His Val Pro Ile Glu Ala Lys 
                645                 650                 655     


Tyr Ile Phe Pro Leu Asp Asp Lys Ala Ala Val Cys Gly Phe Glu Ala 
            660                 665                 670         


Phe Ile Asn Gly Lys His Ile Val Gly Glu Ile Lys Glu Lys Glu Glu 
        675                 680                 685             


Ala Gln Gln Glu Tyr Leu Glu Ala Val Thr Gln Gly His Gly Ala Tyr 
    690                 695                 700                 


Leu Met Ser Gln Asp Ala Pro Asp Val Phe Thr Val Ser Val Gly Asn 
705                 710                 715                 720 


Leu Pro Pro Lys Ala Lys Val Leu Ile Lys Ile Thr Tyr Ile Thr Glu 
                725                 730                 735     


Leu Ser Ile Leu Gly Thr Val Gly Val Phe Phe Met Pro Ala Thr Val 
            740                 745                 750         


Ala Pro Trp Gln Gln Asp Lys Ala Leu Asn Glu Asn Leu Gln Asp Thr 
        755                 760                 765             


Val Glu Lys Ile Cys Ile Lys Glu Ile Gly Thr Lys Gln Ser Phe Ser 
    770                 775                 780                 


Leu Thr Met Ser Ile Glu Met Pro Tyr Val Ile Glu Phe Ile Phe Ser 
785                 790                 795                 800 


Asp Thr His Glu Leu Lys Gln Lys Arg Thr Asp Cys Lys Ala Val Ile 
                805                 810                 815     


Ser Thr Met Glu Gly Ser Ser Leu Asp Ser Ser Gly Phe Ser Leu His 
            820                 825                 830         


Ile Gly Leu Ser Ala Ala Tyr Leu Pro Arg Met Trp Val Glu Lys His 
        835                 840                 845             


Pro Glu Lys Glu Ser Glu Ala Cys Met Leu Val Phe Gln Pro Asp Leu 
    850                 855                 860                 


Asp Val Asp Leu Pro Asp Leu Ala Ser Glu Ser Glu Val Ile Ile Cys 
865                 870                 875                 880 


Leu Asp Cys Ser Ser Ser Met Glu Gly Val Thr Phe Leu Gln Ala Lys 
                885                 890                 895     


Gln Ile Thr Leu His Ala Leu Ser Leu Val Gly Glu Lys Gln Lys Val 
            900                 905                 910         


Asn Ile Ile Gln Phe Gly Thr Gly Tyr Lys Glu Leu Phe Ser Tyr Pro 
        915                 920                 925             


Lys His Ile Thr Ser Asn Thr Thr Ala Ala Glu Phe Ile Met Ser Ala 
    930                 935                 940                 


Thr Pro Thr Met Gly Asn Thr Asp Phe Trp Lys Thr Leu Arg Tyr Leu 
945                 950                 955                 960 


Ser Leu Leu Tyr Pro Ala Arg Gly Ser Arg Asn Ile Leu Leu Val Ser 
                965                 970                 975     


Asp Gly His Leu Gln Asp Glu Ser Leu Thr Leu Gln Leu Val Lys Arg 
            980                 985                 990         


Ser Arg Pro His Thr Arg Leu Phe  Ala Cys Gly Ile Gly  Ser Thr Ala 
        995                 1000                 1005             


Asn Arg  His Val Leu Arg Ile  Leu Ser Gln Cys Gly  Ala Gly Val 
    1010                 1015                 1020             


Phe Glu  Tyr Phe Asn Ala Lys  Ser Lys His Ser Trp  Arg Lys Gln 
    1025                 1030                 1035             


Ile Glu  Asp Gln Met Thr Arg  Leu Cys Ser Pro Ser  Cys His Ser 
    1040                 1045                 1050             


Val Ser  Val Lys Trp Gln Gln  Leu Asn Pro Asp Ala  Pro Glu Ala 
    1055                 1060                 1065             


Leu Gln  Ala Pro Ala Gln Val  Pro Ser Leu Phe Arg  Asn Asp Arg 
    1070                 1075                 1080             


Leu Leu  Val Tyr Gly Phe Ile  Pro His Cys Thr Gln  Ala Thr Leu 
    1085                 1090                 1095             


Cys Ala  Leu Ile Gln Glu Lys  Glu Phe Cys Thr Met  Val Ser Thr 
    1100                 1105                 1110             


Thr Glu  Leu Gln Lys Thr Thr  Gly Thr Met Ile His  Lys Leu Ala 
    1115                 1120                 1125             


Ala Arg  Ala Leu Ile Arg Asp  Tyr Glu Asp Gly Ile  Leu His Glu 
    1130                 1135                 1140             


Asn Glu  Thr Ser His Glu Met  Lys Lys Gln Thr Leu  Lys Ser Leu 
    1145                 1150                 1155             


Ile Ile  Lys Leu Ser Lys Glu  Asn Ser Leu Ile Thr  Gln Phe Thr 
    1160                 1165                 1170             


Ser Phe  Val Ala Val Glu Lys  Arg Asp Glu Asn Glu  Ser Pro Phe 
    1175                 1180                 1185             


Pro Asp  Ile Pro Lys Val Ser  Glu Leu Ile Ala Lys  Glu Asp Val 
    1190                 1195                 1200             


Asp Phe  Leu Pro Tyr Met Ser  Trp Gln Gly Glu Pro  Gln Glu Ala 
    1205                 1210                 1215             


Val Arg  Asn Gln Ser Leu Leu  Ala Ser Ser Glu Trp  Pro Glu Leu 
    1220                 1225                 1230             


Arg Leu  Ser Lys Arg Lys His  Arg Lys Ile Pro Phe  Ser Lys Arg 
    1235                 1240                 1245             


Lys Met  Glu Leu Ser Gln Pro  Glu Val Ser Glu Asp  Phe Glu Glu 
    1250                 1255                 1260             


Asp Gly  Leu Gly Val Leu Pro  Ala Phe Thr Ser Asn  Leu Glu Arg 
    1265                 1270                 1275             


Gly Gly  Val Glu Lys Leu Leu  Asp Leu Ser Trp Thr  Glu Ser Cys 
    1280                 1285                 1290             


Lys Pro  Thr Ala Thr Glu Pro  Leu Phe Lys Lys Val  Ser Pro Trp 
    1295                 1300                 1305             


Glu Thr  Ser Thr Ser Ser Phe  Phe Pro Ile Leu Ala  Pro Ala Val 
    1310                 1315                 1320             


Gly Ser  Tyr Leu Thr Pro Thr  Thr Arg Ala His Ser  Pro Ala Ser 
    1325                 1330                 1335             


Leu Ser  Phe Ala Ser Tyr Arg  Gln Val Ala Ser Phe  Gly Ser Ala 
    1340                 1345                 1350             


Ala Pro  Pro Arg Gln Phe Asp  Ala Ser Gln Phe Ser  Gln Gly Pro 
    1355                 1360                 1365             


Val Pro  Gly Thr Cys Ala Asp  Trp Ile Pro Gln Ser  Ala Ser Cys 
    1370                 1375                 1380             


Pro Thr  Gly Pro Pro Gln Asn  Pro Pro Ser Ala Pro  Tyr Cys Gly 
    1385                 1390                 1395             


Ile Val  Phe Ser Gly Ser Ser  Leu Ser Ser Ala Gln  Ser Ala Pro 
    1400                 1405                 1410             


Leu Gln  His Pro Gly Gly Phe  Thr Thr Arg Pro Ser  Ala Gly Thr 
    1415                 1420                 1425             


Phe Pro  Glu Leu Asp Ser Pro  Gln Leu His Phe Ser  Leu Pro Thr 
    1430                 1435                 1440             


Asp Pro  Asp Pro Ile Arg Gly  Phe Gly Ser Tyr His  Pro Ser Ala 
    1445                 1450                 1455             


Tyr Ser  Pro Phe His Phe Gln  Pro Ser Ala Ala Ser  Leu Thr Ala 
    1460                 1465                 1470             


Asn Leu  Arg Leu Pro Met Ala  Ser Ala Leu Pro Glu  Ala Leu Cys 
    1475                 1480                 1485             


Ser Gln  Ser Arg Thr Thr Pro  Val Asp Leu Cys Leu  Leu Glu Glu 
    1490                 1495                 1500             


Ser Val  Gly Ser Leu Glu Gly  Ser Arg Cys Pro Val  Phe Ala Phe 
    1505                 1510                 1515             


Gln Ser  Ser Asp Thr Glu Ser  Asp Glu Leu Ser Glu  Val Leu Gln 
    1520                 1525                 1530             


Asp Ser  Cys Phe Leu Gln Ile  Lys Cys Asp Thr Lys  Asp Asp Ser 
    1535                 1540                 1545             


Ile Pro  Cys Phe Leu Glu Leu  Lys Glu Glu Asp Glu  Ile Val Cys 
    1550                 1555                 1560             


Thr Gln  His Trp Gln Asp Ala  Val Pro Trp Thr Glu  Leu Leu Ser 
    1565                 1570                 1575             


Leu Gln  Thr Glu Asp Gly Phe  Trp Lys Leu Thr Pro  Glu Leu Gly 
    1580                 1585                 1590             


Leu Ile  Leu Asn Leu Asn Thr  Asn Gly Leu His Ser  Phe Leu Lys 
    1595                 1600                 1605             


Gln Lys  Gly Ile Gln Ser Leu  Gly Val Lys Gly Arg  Glu Cys Leu 
    1610                 1615                 1620             


Leu Asp  Leu Ile Ala Thr Met  Leu Val Leu Gln Phe  Ile Arg Thr 
    1625                 1630                 1635             


Arg Leu  Glu Lys Glu Gly Ile  Val Phe Lys Ser Leu  Met Lys Met 
    1640                 1645                 1650             


Asp Asp  Pro Ser Ile Ser Arg  Asn Ile Pro Trp Ala  Phe Glu Ala 
    1655                 1660                 1665             


Ile Lys  Gln Ala Ser Glu Trp  Val Arg Arg Thr Glu  Gly Gln Tyr 
    1670                 1675                 1680             


Pro Ser  Ile Cys Pro Arg Leu  Glu Leu Gly Asn Asp  Trp Asp Ser 
    1685                 1690                 1695             


Ala Thr  Lys Gln Leu Leu Gly  Leu Gln Pro Ile Ser  Thr Val Ser 
    1700                 1705                 1710             


Pro Leu  His Arg Val Leu His  Tyr Ser Gln Gly 
    1715                 1720                 


<210>  4
<211>  5175
<212>  DNA
<213>  Homo sapiens

<400>  4
atggtgatgg gaatctttgc aaattgtatc ttctgtttga aagtgaagta cttacctcag       60

cagcagaaga aaaagctaca aactgacatt aaggaaaatg gcggaaagtt ttccttttcg      120

ttaaatcctc agtgcacaca tataatctta gataatgctg atgttctgag tcagtaccaa      180

ctgaattcta tccaaaagaa ccacgttcat attgcaaacc cagattttat atggaaatct      240

atcagagaaa agagactctt ggatgtaaag aattatgatc cttataagcc cctggacatc      300

acaccacctc ctgatcagaa ggcgagcagt tctgaagtga aaacagaagg tctatgcccg      360

gacagtgcca cagaggagga agacactgtg gaactcactg agtttggtat gcagaatgtt      420

gaaattcctc atcttcctca agattttgaa gttgcaaaat ataacacctt ggagaaagtg      480

ggaatggagg gaggccagga agctgtggtg gtggagcttc agtgttcgcg ggactccagg      540

gactgtcctt tcctgatatc ctcacacttc ctcctggatg atggcatgga gactagaaga      600

cagtttgcta taaagaaaac ctctgaagat gcaagtgaat actttgaaaa ttacattgaa      660

gaactgaaga aacaaggatt tctactaaga gaacatttca cacctgaagc aacccaatta      720

gcatctgaac aattgcaagc attgcttttg gaggaagtca tgaattcaag cactctgagc      780

caagaggtga gcgatttagt agagatgatt tgggcagagg ccctgggcca cctggaacac      840

atgcttctca agccagtgaa caggattagc ctcaacgatg tgagcaaggc agaggggatt      900

ctccttctag taaaggcagc actgaaaaat ggagaaacag cagagcaatt gcaaaagatg      960

atgacagagt tttacagact gatacctcac aaaggcacaa tgcccaaaga agtgaacctg     1020

ggactattgg ctaagaaagc agacctctgc cagctaataa gagacatggt taatgtctgt     1080

gaaactaatt tgtccaaacc caacccacca tccctggcca aataccgagc tttgaggtgc     1140

aaaattgagc atgttgaaca gaatactgaa gaatttctca gggttagaaa agaggttttg     1200

cagaatcatc acagtaagag cccagtggat gtcttgcaga tatttagagt tggcagagtg     1260

aatgaaacca cagagttttt gagcaaactt ggtaatgtga ggcccttgtt gcatggttct     1320

cctgtacaaa acatcgtggg aatcttgtgt cgagggttgc ttttacccaa agtagtggaa     1380

gatcgtggtg tgcaaagaac agacgtcgga aaccttggaa gtgggattta tttcagtgat     1440

tcgctcagta caagtatcaa gtactcacac ccgggagaga cagatggcac cagactcctg     1500

ctcatttgtg acgtagccct cggaaagtgt atggacttac atgagaagga ctttccctta     1560

actgaagcac caccaggcta cgacagtgtg catggagttt cacaaacagc ctctgtcacc     1620

acagactttg aggatgatga atttgttgtc tataaaacca atcaggttaa aatgaaatat     1680

attattaaat tttccatgcc tggagatcag ataaaggact ttcatcctag tgatcatact     1740

gaattagagg aatacagacc tgagttttca aatttttcaa aggttgaaga ttaccagtta     1800

ccagatgcca aaacttccag cagcaccaag gccggcctcc aggatgcctc tgggaacttg     1860

gttcctctgg aggatgtcca catcaaaggg agaatcatag acactgtagc ccaggtcatt     1920

gtttttcaga catacacaaa taaaagtcac gtgcccattg aggcaaaata tatctttcct     1980

ttggatgaca aggccgctgt gtgtggcttc gaagccttca tcaatgggaa gcacatagtt     2040

ggagagatta aagagaagga agaagcccag caagagtacc tagaagccgt gacccagggc     2100

catggcgctt acctgatgag tcaggatgct ccggacgttt ttactgtaag tgttggaaac     2160

ttacccccta aggctaaggt tcttataaaa attacctaca tcacagaact cagcatcctg     2220

ggcactgttg gtgtcttttt catgcccgcc accgtagcac cctggcaaca ggacaaggct     2280

ttgaatgaaa accttcagga tacagtagag aagatttgta taaaagaaat aggaacaaag     2340

caaagcttct ctttgactat gtctattgag atgccgtatg tgattgaatt cattttcagt     2400

gatacacatg aactgaaaca aaagcgcaca gactgcaaag ctgtcattag caccatggaa     2460

ggcagctcct tagacagcag tggattttct ctccacatcg gtttgtctgc tgcctatctc     2520

ccaagaatgt gggttgaaaa acatccagaa aaagaaagcg aggcttgcat gcttgtcttt     2580

caacccgatc tcgatgtcga cctccctgac ctagccagtg agagcgaagt gattatttgt     2640

cttgactgct ccagttccat ggagggtgtg acattcttgc aagccaagca aatcaccttg     2700

catgcgctgt ccttggtggg tgagaagcag aaagtaaata ttatccagtt cggcacaggt     2760

tacaaggagc tattttcgta tcctaagcat atcacaagca ataccacggc agcagagttc     2820

atcatgtctg ccacacctac catggggaac acagacttct ggaaaacact ccgatatctt     2880

agcttattgt accctgctcg agggtcacgg aacatcctcc tggtgtctga tgggcacctc     2940

caggatgaga gcctgacatt acagctcgtg aagaggagcc gcccgcacac caggttattc     3000

gcctgcggta tcggttctac agcaaatcgt cacgtcttaa ggattttgtc ccagtgtggt     3060

gccggagtat ttgaatattt taatgcaaaa tccaagcata gttggagaaa acagatagaa     3120

gaccaaatga ccaggctatg ttctccgagt tgccactctg tctccgtcaa atggcagcaa     3180

ctcaatccag atgcgcccga ggccctgcag gccccagccc aggtgccatc cttgtttcgc     3240

aatgatcgac tccttgtcta tggattcatt cctcactgca cacaagcaac tctgtgtgca     3300

ctaattcaag agaaagaatt ttgtacaatg gtgtcgacta ctgagcttca gaagacaact     3360

ggaactatga tccacaagct ggcagcccga gctctaatca gagattatga agatggcatt     3420

cttcacgaaa atgaaaccag tcatgagatg aaaaaacaaa ccttgaaatc tctgattatt     3480

aaactcagta aagaaaactc tctcataaca caatttacaa gctttgtggc agttgagaaa     3540

agggatgaga atgagtcgcc ttttcctgat attccaaaag tttctgaact tattgccaaa     3600

gaagatgtag acttcctgcc ctacatgagc tggcaggggg agccccaaga agccgtcagg     3660

aaccagtctc ttttagcatc ctctgagtgg ccagaattac gtttatccaa acgaaaacat     3720

aggaaaattc cattttccaa aagaaaaatg gaattatctc agccagaagt ttctgaagat     3780

tttgaagagg atggcttagg tgtactacca gctttcacat caaatttgga acgtggaggt     3840

gtggaaaagc tattggattt aagttggaca gagtcatgta aaccaacagc aactgaacca     3900

ctatttaaga aagtcagtcc atgggaaaca tctacttcta gcttttttcc tattttggct     3960

ccggccgttg gttcctatct taccccgact acccgcgctc acagtcctgc ttccttgtct     4020

tttgcctcat atcgtcaggt agctagtttc ggttcagctg ctcctcccag acagtttgat     4080

gcatctcaat tcagccaagg ccctgtgcct ggcacttgtg ctgactggat cccacagtcg     4140

gcgtcttgtc ccacaggacc tccccagaac ccaccttctg caccctattg tggcattgtt     4200

ttttcaggga gctcattaag ctctgcacag tctgctccac tgcaacatcc tggaggcttt     4260

actaccaggc cttctgctgg caccttccct gagctggatt ctccccagct tcatttctct     4320

cttcctacag accctgatcc catcagaggt tttgggtctt atcatccctc tgcttactct     4380

ccttttcatt ttcaaccttc cgcagcctct ttgactgcca accttaggct gccaatggcc     4440

tctgctttac ctgaggctct ttgcagtcag tcccggacta ccccagtaga tctctgtctt     4500

ctagaagaat cagtaggcag tctcgaagga agtcgatgtc ctgtctttgc ttttcaaagt     4560

tctgacacag aaagtgatga gctatcagaa gtacttcaag acagctgctt tttacaaata     4620

aagtgtgata caaaagatga cagtatcccg tgctttctgg aattaaaaga agaggatgaa     4680

atagtgtgca cacaacactg gcaggatgct gtgccttgga cagaactcct cagtctacag     4740

acagaggatg gcttctggaa acttacacca gaactgggac ttatattaaa tcttaataca     4800

aatggtttgc acagctttct taaacaaaaa ggcattcaat ctctaggtgt aaaaggaaga     4860

gaatgtctcc tggacctaat tgccacaatg ctggtactac agtttattcg caccaggttg     4920

gaaaaagagg gaatagtgtt caaatcactg atgaaaatgg atgacccttc tatttccagg     4980

aatattccct gggcttttga ggcaataaag caagcaagtg aatgggtaag aagaactgaa     5040

ggacagtacc catctatctg cccacggctt gaactgggga acgactggga ctctgccacc     5100

aagcagttgc tgggactcca gcccataagc actgtgtccc ctcttcatag agtcctccat     5160

tacagtcaag gctaa                                                      5175


<210>  5
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Thr Glu Glu Phe Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Met 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Thr Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Ala Gln Gly Leu Val Leu Phe Asp Val Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Leu Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asp Gly Asp Lys Val Val Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Arg Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Ile Ile Arg Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Trp Asp Arg Asp Gly Lys Glu Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Thr Thr Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Arg Arg Asn Phe Arg Asp Phe Arg Gly 
225                 230                 235                 240 


Val Ser Arg Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val His Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro His Asn Tyr Cys Val Ile Leu Asp Pro Val 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Gln Leu Glu Gln Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Arg Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Asp Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp His Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Glu 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Pro Gly Val Glu Glu Leu Leu Asn Lys Gly Gln Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Glu Lys Asp Thr Ala Lys Ser Leu Gln Pro 
        435                 440                 445             


Leu Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Glu Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Ser Leu Gly Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Val Asn Asp Arg Lys Asp Pro Gln Glu Thr Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Thr Ala Val Phe Gly Phe Glu Thr 
        595                 600                 605             


Ser Glu Ala Lys Gly Pro Asp Gly Met Ala Leu Pro Arg Pro Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Leu Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Thr Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Gln Arg Val Gln Lys Val Arg Glu Leu 
        755                 760                 765             


Glu Leu Val Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Glu Val Glu Val Lys Lys Phe Lys Gln Met Thr Glu 
785                 790                 795                 800 


Ala Ile Gly Pro Ser Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Thr Pro Ile Asn Leu Phe Asn Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Met Gly Pro Glu Gly Gln Pro Leu Gly Arg Arg Val Ala Ser 
    850                 855                 860                 


Gly Pro Ser Pro Gly Glu Gly Ile Ser Pro Gln Ser Ala Gln Ala Pro 
865                 870                 875                 880 


Gln Ala Pro Gly Asp Asn His Val Val Pro Val Leu Arg 
                885                 890             


<210>  6
<211>  2682
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcaactg aagagttcat catccgcatc cccccatacc actatatcca tgtgctggac       60

cagaacagca acgtgtcccg tgtggaggtc gggccaaaga cctacatccg gcaggacaat      120

gagagggtac tgtttgcccc catgcgcatg gtgaccgtcc ccccacgtca ctactgcaca      180

gtggccaacc ctgtgtctcg ggatgcccag ggcttggtgc tgtttgatgt cacagggcaa      240

gttcggcttc gccacgctga cctcgagatc cggctggccc aggacccctt ccccctgtac      300

ccaggggagg tgctggaaaa ggacatcaca cccctgcagg tggttctgcc caacactgcc      360

ctccatctaa aggcgctgct tgattttgag gataaagatg gagacaaggt ggtggcagga      420

gatgagtggc ttttcgaggg acctggcacg tacatccccc ggaaggaagt ggaggtcgtg      480

gagatcattc aggccaccat catcaggcag aaccaggctc tgcggctcag ggcccgcaag      540

gagtgctggg accgggacgg caaggagagg gtgacagggg aagaatggct ggtcaccaca      600

gtaggggcgt acctcccagc ggtgtttgag gaggttctgg atttggtgga cgccgtcatc      660

cttacggaaa agacagccct gcacctccgg gctcggcgga acttccggga cttcagggga      720

gtgtcccgcc gcactgggga ggagtggctg gtaacagtgc aggacacaga ggcccacgtg      780

ccagatgtcc acgaggaggt gctgggggtt gtgcccatca ccaccctggg cccccacaac      840

tactgcgtga ttctcgaccc tgtcggaccg gatggcaaga atcagctggg gcagaagcgc      900

gtggtcaagg gagagaagtc ttttttcctc cagccaggag agcagctgga acaaggcatc      960

caggatgtgt atgtgctgtc ggagcagcag gggctgctgc tgagggccct gcagcccctg     1020

gaggaggggg aggatgagga gaaggtctca caccaggctg gggaccactg gctcatccgc     1080

ggacccctgg agtatgtgcc atctgccaaa gtggaggtgg tggaggagcg ccaggccatc     1140

cctctagacg agaacgaggg catctatgtg caggatgtca agaccggaaa ggtgcgcgct     1200

gtgattggaa gcacctacat gctgacccag gacgaagtcc tgtgggagaa agagctgcct     1260

cccggggtgg aggagctgct gaacaagggg caggaccctc tggcagacag gggtgagaag     1320

gacacagcta agagcctcca gcccttggcg ccccggaaca agacccgtgt ggtcagctac     1380

cgcgtgcccc acaacgctgc ggtgcaggtg tacgactacc gagagaagcg agcccgcgtg     1440

gtcttcgggc ctgagctggt gtcgctgggt cctgaggagc agttcacagt gttgtccctc     1500

tcagctgggc ggcccaagcg tccccatgcc cgccgtgcgc tctgcctgct gctggggcct     1560

gacttcttca cagacgtcat caccatcgaa acggcggatc atgccaggct gcaactgcag     1620

ctggcctaca actggcactt tgaggtgaat gaccggaagg acccccaaga gacggccaag     1680

ctcttttcag tgccagactt tgtaggtgat gcctgcaaag ccatcgcatc ccgggtgcgg     1740

ggggccgtgg cctctgtcac tttcgatgac ttccataaga actcagcccg catcattcgc     1800

actgctgtct ttggctttga gacctcggaa gcgaagggcc ccgatggcat ggccctgccc     1860

aggccccggg accaggctgt cttcccccaa aacgggctgg tggtcagcag tgtggacgtg     1920

cagtcagtgg agcctgtgga tcagaggacc cgggacgccc tgcaacgcag cgtccagctg     1980

gccatcgaga tcaccaccaa ctcccaggaa gcggcggcca agcatgaggc tcagagactg     2040

gagcaggaag cccgcggccg gcttgagcgg cagaagatcc tggaccagtc agaagccgag     2100

aaagctcgca aggaactttt ggagctggag gctctgagca tggccgtgga gagcaccggg     2160

actgccaagg cggaggccga gtcccgtgcg gaggcagccc ggattgaggg agaagggtcc     2220

gtgctgcagg ccaagctaaa agcacaggcc ttggccattg aaacggaggc tgagctccag     2280

agggtccaga aggtccgaga gctggaactg gtctatgccc gggcccagct ggagctggag     2340

gtgagcaagg ctcagcagct ggctgaggtg gaggtgaaga agttcaagca gatgacagag     2400

gccataggcc ccagcaccat cagggacctt gctgtggctg ggcctgagat gcaggtaaaa     2460

ctgctccagt ccctgggcct gaaatcaacc ctcatcaccg atggctccac tcccatcaac     2520

ctcttcaaca cagcctttgg gctgctgggg atggggcccg agggtcagcc cctgggcaga     2580

agggtggcca gtgggcccag ccctggggag gggatatccc cccagtctgc tcaggcccct     2640

caagctcctg gagacaacca cgtggtgcct gtactgcgct aa                        2682


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gly Cys Gly Cys Pro Cys Gly Cys Gly Ala 
1               5                   10          


<210>  8
<211>  905
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-hMVP based on Homo sapien

<400>  8

Met Ala Gly Cys Gly Cys Pro Cys Gly Cys Gly Ala Met Ala Thr Glu 
1               5                   10                  15      


Glu Phe Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His Val Leu Asp 
            20                  25                  30          


Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys Thr Tyr Ile 
        35                  40                  45              


Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Met Arg Met Val Thr 
    50                  55                  60                  


Val Pro Pro Arg His Tyr Cys Thr Val Ala Asn Pro Val Ser Arg Asp 
65                  70                  75                  80  


Ala Gln Gly Leu Val Leu Phe Asp Val Thr Gly Gln Val Arg Leu Arg 
                85                  90                  95      


His Ala Asp Leu Glu Ile Arg Leu Ala Gln Asp Pro Phe Pro Leu Tyr 
            100                 105                 110         


Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln Val Val Leu 
        115                 120                 125             


Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe Glu Asp Lys 
    130                 135                 140                 


Asp Gly Asp Lys Val Val Ala Gly Asp Glu Trp Leu Phe Glu Gly Pro 
145                 150                 155                 160 


Gly Thr Tyr Ile Pro Arg Lys Glu Val Glu Val Val Glu Ile Ile Gln 
                165                 170                 175     


Ala Thr Ile Ile Arg Gln Asn Gln Ala Leu Arg Leu Arg Ala Arg Lys 
            180                 185                 190         


Glu Cys Trp Asp Arg Asp Gly Lys Glu Arg Val Thr Gly Glu Glu Trp 
        195                 200                 205             


Leu Val Thr Thr Val Gly Ala Tyr Leu Pro Ala Val Phe Glu Glu Val 
    210                 215                 220                 


Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr Ala Leu His 
225                 230                 235                 240 


Leu Arg Ala Arg Arg Asn Phe Arg Asp Phe Arg Gly Val Ser Arg Arg 
                245                 250                 255     


Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu Ala His Val 
            260                 265                 270         


Pro Asp Val His Glu Glu Val Leu Gly Val Val Pro Ile Thr Thr Leu 
        275                 280                 285             


Gly Pro His Asn Tyr Cys Val Ile Leu Asp Pro Val Gly Pro Asp Gly 
    290                 295                 300                 


Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu Lys Ser Phe 
305                 310                 315                 320 


Phe Leu Gln Pro Gly Glu Gln Leu Glu Gln Gly Ile Gln Asp Val Tyr 
                325                 330                 335     


Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Arg Ala Leu Gln Pro Leu 
            340                 345                 350         


Glu Glu Gly Glu Asp Glu Glu Lys Val Ser His Gln Ala Gly Asp His 
        355                 360                 365             


Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala Lys Val Glu 
    370                 375                 380                 


Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Glu Asn Glu Gly Ile 
385                 390                 395                 400 


Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val Ile Gly Ser 
                405                 410                 415     


Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys Glu Leu Pro 
            420                 425                 430         


Pro Gly Val Glu Glu Leu Leu Asn Lys Gly Gln Asp Pro Leu Ala Asp 
        435                 440                 445             


Arg Gly Glu Lys Asp Thr Ala Lys Ser Leu Gln Pro Leu Ala Pro Arg 
    450                 455                 460                 


Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn Ala Ala Val 
465                 470                 475                 480 


Gln Val Tyr Asp Tyr Arg Glu Lys Arg Ala Arg Val Val Phe Gly Pro 
                485                 490                 495     


Glu Leu Val Ser Leu Gly Pro Glu Glu Gln Phe Thr Val Leu Ser Leu 
            500                 505                 510         


Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala Leu Cys Leu 
        515                 520                 525             


Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile Glu Thr Ala 
    530                 535                 540                 


Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp His Phe Glu 
545                 550                 555                 560 


Val Asn Asp Arg Lys Asp Pro Gln Glu Thr Ala Lys Leu Phe Ser Val 
                565                 570                 575     


Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser Arg Val Arg 
            580                 585                 590         


Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys Asn Ser Ala 
        595                 600                 605             


Arg Ile Ile Arg Thr Ala Val Phe Gly Phe Glu Thr Ser Glu Ala Lys 
    610                 615                 620                 


Gly Pro Asp Gly Met Ala Leu Pro Arg Pro Arg Asp Gln Ala Val Phe 
625                 630                 635                 640 


Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln Ser Val Glu 
                645                 650                 655     


Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser Val Gln Leu 
            660                 665                 670         


Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala Lys His Glu 
        675                 680                 685             


Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu Arg Gln Lys 
    690                 695                 700                 


Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu Leu Leu Glu 
705                 710                 715                 720 


Leu Glu Ala Leu Ser Met Ala Val Glu Ser Thr Gly Thr Ala Lys Ala 
                725                 730                 735     


Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly Glu Gly Ser 
            740                 745                 750         


Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile Glu Thr Glu 
        755                 760                 765             


Ala Glu Leu Gln Arg Val Gln Lys Val Arg Glu Leu Glu Leu Val Tyr 
    770                 775                 780                 


Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln Gln Leu Ala 
785                 790                 795                 800 


Glu Val Glu Val Lys Lys Phe Lys Gln Met Thr Glu Ala Ile Gly Pro 
                805                 810                 815     


Ser Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met Gln Val Lys 
            820                 825                 830         


Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr Asp Gly Ser 
        835                 840                 845             


Thr Pro Ile Asn Leu Phe Asn Thr Ala Phe Gly Leu Leu Gly Met Gly 
    850                 855                 860                 


Pro Glu Gly Gln Pro Leu Gly Arg Arg Val Ala Ser Gly Pro Ser Pro 
865                 870                 875                 880 


Gly Glu Gly Ile Ser Pro Gln Ser Ala Gln Ala Pro Gln Ala Pro Gly 
                885                 890                 895     


Asp Asn His Val Val Pro Val Leu Arg 
            900                 905 


<210>  9
<211>  2718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CP-hMVP cDNA based on Homo sapien

<400>  9
atggcaggct gcggttgtcc atgcggttgt ggcgccatgg caactgaaga gttcatcatc       60

cgcatccccc cataccacta tatccatgtg ctggaccaga acagcaacgt gtcccgtgtg      120

gaggtcgggc caaagaccta catccggcag gacaatgaga gggtactgtt tgcccccatg      180

cgcatggtga ccgtcccccc acgtcactac tgcacagtgg ccaaccctgt gtctcgggat      240

gcccagggct tggtgctgtt tgatgtcaca gggcaagttc ggcttcgcca cgctgacctc      300

gagatccggc tggcccagga ccccttcccc ctgtacccag gggaggtgct ggaaaaggac      360

atcacacccc tgcaggtggt tctgcccaac actgccctcc atctaaaggc gctgcttgat      420

tttgaggata aagatggaga caaggtggtg gcaggagatg agtggctttt cgagggacct      480

ggcacgtaca tcccccggaa ggaagtggag gtcgtggaga tcattcaggc caccatcatc      540

aggcagaacc aggctctgcg gctcagggcc cgcaaggagt gctgggaccg ggacggcaag      600

gagagggtga caggggaaga atggctggtc accacagtag gggcgtacct cccagcggtg      660

tttgaggagg ttctggattt ggtggacgcc gtcatcctta cggaaaagac agccctgcac      720

ctccgggctc ggcggaactt ccgggacttc aggggagtgt cccgccgcac tggggaggag      780

tggctggtaa cagtgcagga cacagaggcc cacgtgccag atgtccacga ggaggtgctg      840

ggggttgtgc ccatcaccac cctgggcccc cacaactact gcgtgattct cgaccctgtc      900

ggaccggatg gcaagaatca gctggggcag aagcgcgtgg tcaagggaga gaagtctttt      960

ttcctccagc caggagagca gctggaacaa ggcatccagg atgtgtatgt gctgtcggag     1020

cagcaggggc tgctgctgag ggccctgcag cccctggagg agggggagga tgaggagaag     1080

gtctcacacc aggctgggga ccactggctc atccgcggac ccctggagta tgtgccatct     1140

gccaaagtgg aggtggtgga ggagcgccag gccatccctc tagacgagaa cgagggcatc     1200

tatgtgcagg atgtcaagac cggaaaggtg cgcgctgtga ttggaagcac ctacatgctg     1260

acccaggacg aagtcctgtg ggagaaagag ctgcctcccg gggtggagga gctgctgaac     1320

aaggggcagg accctctggc agacaggggt gagaaggaca cagctaagag cctccagccc     1380

ttggcgcccc ggaacaagac ccgtgtggtc agctaccgcg tgccccacaa cgctgcggtg     1440

caggtgtacg actaccgaga gaagcgagcc cgcgtggtct tcgggcctga gctggtgtcg     1500

ctgggtcctg aggagcagtt cacagtgttg tccctctcag ctgggcggcc caagcgtccc     1560

catgcccgcc gtgcgctctg cctgctgctg gggcctgact tcttcacaga cgtcatcacc     1620

atcgaaacgg cggatcatgc caggctgcaa ctgcagctgg cctacaactg gcactttgag     1680

gtgaatgacc ggaaggaccc ccaagagacg gccaagctct tttcagtgcc agactttgta     1740

ggtgatgcct gcaaagccat cgcatcccgg gtgcgggggg ccgtggcctc tgtcactttc     1800

gatgacttcc ataagaactc agcccgcatc attcgcactg ctgtctttgg ctttgagacc     1860

tcggaagcga agggccccga tggcatggcc ctgcccaggc cccgggacca ggctgtcttc     1920

ccccaaaacg ggctggtggt cagcagtgtg gacgtgcagt cagtggagcc tgtggatcag     1980

aggacccggg acgccctgca acgcagcgtc cagctggcca tcgagatcac caccaactcc     2040

caggaagcgg cggccaagca tgaggctcag agactggagc aggaagcccg cggccggctt     2100

gagcggcaga agatcctgga ccagtcagaa gccgagaaag ctcgcaagga acttttggag     2160

ctggaggctc tgagcatggc cgtggagagc accgggactg ccaaggcgga ggccgagtcc     2220

cgtgcggagg cagcccggat tgagggagaa gggtccgtgc tgcaggccaa gctaaaagca     2280

caggccttgg ccattgaaac ggaggctgag ctccagaggg tccagaaggt ccgagagctg     2340

gaactggtct atgcccgggc ccagctggag ctggaggtga gcaaggctca gcagctggct     2400

gaggtggagg tgaagaagtt caagcagatg acagaggcca taggccccag caccatcagg     2460

gaccttgctg tggctgggcc tgagatgcag gtaaaactgc tccagtccct gggcctgaaa     2520

tcaaccctca tcaccgatgg ctccactccc atcaacctct tcaacacagc ctttgggctg     2580

ctggggatgg ggcccgaggg tcagcccctg ggcagaaggg tggccagtgg gcccagccct     2640

ggggagggga tatcccccca gtctgctcag gcccctcaag ctcctggaga caaccacgtg     2700

gtgcctgtac tgcgctaa                                                   2718


<210>  10
<211>  2627
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Lys Leu His Gly His Val Ser Ala His Pro Asp Ile Leu Ser 
1               5                   10                  15      


Leu Glu Asn Arg Cys Leu Ala Met Leu Pro Asp Leu Gln Pro Leu Glu 
            20                  25                  30          


Lys Leu His Gln His Val Ser Thr His Ser Asp Ile Leu Ser Leu Lys 
        35                  40                  45              


Asn Gln Cys Leu Ala Thr Leu Pro Asp Leu Lys Thr Met Glu Lys Pro 
    50                  55                  60                  


His Gly Tyr Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Gln 
65                  70                  75                  80  


Cys Leu Ala Thr Leu Ser Asp Leu Lys Thr Met Glu Lys Pro His Gly 
                85                  90                  95      


His Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Arg Cys Leu 
            100                 105                 110         


Ala Thr Leu Pro Ser Leu Lys Ser Thr Val Ser Ala Ser Pro Leu Phe 
        115                 120                 125             


Gln Ser Leu Gln Ile Ser His Met Thr Gln Ala Asp Leu Tyr Arg Val 
    130                 135                 140                 


Asn Asn Ser Asn Cys Leu Leu Ser Glu Pro Pro Ser Trp Arg Ala Gln 
145                 150                 155                 160 


His Phe Ser Lys Gly Leu Asp Leu Ser Thr Cys Pro Ile Ala Leu Lys 
                165                 170                 175     


Ser Ile Ser Ala Thr Glu Thr Ala Gln Glu Ala Thr Leu Gly Arg Trp 
            180                 185                 190         


Phe Asp Ser Glu Glu Lys Lys Gly Ala Glu Thr Gln Met Pro Ser Tyr 
        195                 200                 205             


Ser Leu Ser Leu Gly Glu Glu Glu Glu Val Glu Asp Leu Ala Val Lys 
    210                 215                 220                 


Leu Thr Ser Gly Asp Ser Glu Ser His Pro Glu Pro Thr Asp His Val 
225                 230                 235                 240 


Leu Gln Glu Lys Lys Met Ala Leu Leu Ser Leu Leu Cys Ser Thr Leu 
                245                 250                 255     


Val Ser Glu Val Asn Met Asn Asn Thr Ser Asp Pro Thr Leu Ala Ala 
            260                 265                 270         


Ile Phe Glu Ile Cys Arg Glu Leu Ala Leu Leu Glu Pro Glu Phe Ile 
        275                 280                 285             


Leu Lys Ala Ser Leu Tyr Ala Arg Gln Gln Leu Asn Val Arg Asn Val 
    290                 295                 300                 


Ala Asn Asn Ile Leu Ala Ile Ala Ala Phe Leu Pro Ala Cys Arg Pro 
305                 310                 315                 320 


His Leu Arg Arg Tyr Phe Cys Ala Ile Val Gln Leu Pro Ser Asp Trp 
                325                 330                 335     


Ile Gln Val Ala Glu Leu Tyr Gln Ser Leu Ala Glu Gly Asp Lys Asn 
            340                 345                 350         


Lys Leu Val Pro Leu Pro Ala Cys Leu Arg Thr Ala Met Thr Asp Lys 
        355                 360                 365             


Phe Ala Gln Phe Asp Glu Tyr Gln Leu Ala Lys Tyr Asn Pro Arg Lys 
    370                 375                 380                 


His Arg Ala Lys Arg His Pro Arg Arg Pro Pro Arg Ser Pro Gly Met 
385                 390                 395                 400 


Glu Pro Pro Phe Ser His Arg Cys Phe Pro Arg Tyr Ile Gly Phe Leu 
                405                 410                 415     


Arg Glu Glu Gln Arg Lys Phe Glu Lys Ala Gly Asp Thr Val Ser Glu 
            420                 425                 430         


Lys Lys Asn Pro Pro Arg Phe Thr Leu Lys Lys Leu Val Gln Arg Leu 
        435                 440                 445             


His Ile His Lys Pro Ala Gln His Val Gln Ala Leu Leu Gly Tyr Arg 
    450                 455                 460                 


Tyr Pro Ser Asn Leu Gln Leu Phe Ser Arg Ser Arg Leu Pro Gly Pro 
465                 470                 475                 480 


Trp Asp Ser Ser Arg Ala Gly Lys Arg Met Lys Leu Ser Arg Pro Glu 
                485                 490                 495     


Thr Trp Glu Arg Glu Leu Ser Leu Arg Gly Asn Lys Ala Ser Val Trp 
            500                 505                 510         


Glu Glu Leu Ile Glu Asn Gly Lys Leu Pro Phe Met Ala Met Leu Arg 
        515                 520                 525             


Asn Leu Cys Asn Leu Leu Arg Val Gly Ile Ser Ser Arg His His Glu 
    530                 535                 540                 


Leu Ile Leu Gln Arg Leu Gln His Gly Lys Ser Val Ile His Ser Arg 
545                 550                 555                 560 


Gln Phe Pro Phe Arg Phe Leu Asn Ala His Asp Ala Ile Asp Ala Leu 
                565                 570                 575     


Glu Ala Gln Leu Arg Asn Gln Ala Leu Pro Phe Pro Ser Asn Ile Thr 
            580                 585                 590         


Leu Met Arg Arg Ile Leu Thr Arg Asn Glu Lys Asn Arg Pro Arg Arg 
        595                 600                 605             


Arg Phe Leu Cys His Leu Ser Arg Gln Gln Leu Arg Met Ala Met Arg 
    610                 615                 620                 


Ile Pro Val Leu Tyr Glu Gln Leu Lys Arg Glu Lys Leu Arg Val His 
625                 630                 635                 640 


Lys Ala Arg Gln Trp Lys Tyr Asp Gly Glu Met Leu Asn Arg Tyr Arg 
                645                 650                 655     


Gln Ala Leu Glu Thr Ala Val Asn Leu Ser Val Lys His Ser Leu Pro 
            660                 665                 670         


Leu Leu Pro Gly Arg Thr Val Leu Val Tyr Leu Thr Asp Ala Asn Ala 
        675                 680                 685             


Asp Arg Leu Cys Pro Lys Ser Asn Pro Gln Gly Pro Pro Leu Asn Tyr 
    690                 695                 700                 


Ala Leu Leu Leu Ile Gly Met Met Ile Thr Arg Ala Glu Gln Val Asp 
705                 710                 715                 720 


Val Val Leu Cys Gly Gly Asp Thr Leu Lys Thr Ala Val Leu Lys Ala 
                725                 730                 735     


Glu Glu Gly Ile Leu Lys Thr Ala Ile Lys Leu Gln Ala Gln Val Gln 
            740                 745                 750         


Glu Phe Asp Glu Asn Asp Gly Trp Ser Leu Asn Thr Phe Gly Lys Tyr 
        755                 760                 765             


Leu Leu Ser Leu Ala Gly Gln Arg Val Pro Val Asp Arg Val Ile Leu 
    770                 775                 780                 


Leu Gly Gln Ser Met Asp Asp Gly Met Ile Asn Val Ala Lys Gln Leu 
785                 790                 795                 800 


Tyr Trp Gln Arg Val Asn Ser Lys Cys Leu Phe Val Gly Ile Leu Leu 
                805                 810                 815     


Arg Arg Val Gln Tyr Leu Ser Thr Asp Leu Asn Pro Asn Asp Val Thr 
            820                 825                 830         


Leu Ser Gly Cys Thr Asp Ala Ile Leu Lys Phe Ile Ala Glu His Gly 
        835                 840                 845             


Ala Ser His Leu Leu Glu His Val Gly Gln Met Asp Lys Ile Phe Lys 
    850                 855                 860                 


Ile Pro Pro Pro Pro Gly Lys Thr Gly Val Gln Ser Leu Arg Pro Leu 
865                 870                 875                 880 


Glu Glu Asp Thr Pro Ser Pro Leu Ala Pro Val Ser Gln Gln Gly Trp 
                885                 890                 895     


Arg Ser Ile Arg Leu Phe Ile Ser Ser Thr Phe Arg Asp Met His Gly 
            900                 905                 910         


Glu Arg Asp Leu Leu Leu Arg Ser Val Leu Pro Ala Leu Gln Ala Arg 
        915                 920                 925             


Ala Ala Pro His Arg Ile Ser Leu His Gly Ile Asp Leu Arg Trp Gly 
    930                 935                 940                 


Val Thr Glu Glu Glu Thr Arg Arg Asn Arg Gln Leu Glu Val Cys Leu 
945                 950                 955                 960 


Gly Glu Val Glu Asn Ala Gln Leu Phe Val Gly Ile Leu Gly Ser Arg 
                965                 970                 975     


Tyr Gly Tyr Ile Pro Pro Ser Tyr Asn Leu Pro Asp His Pro His Phe 
            980                 985                 990         


His Trp Ala Gln Gln Tyr Pro Ser  Gly Arg Ser Val Thr  Glu Met Glu 
        995                 1000                 1005             


Val Met  Gln Phe Leu Asn Arg  Asn Gln Arg Leu Gln  Pro Ser Ala 
    1010                 1015                 1020             


Gln Ala  Leu Ile Tyr Phe Arg  Asp Ser Ser Phe Leu  Ser Ser Val 
    1025                 1030                 1035             


Pro Asp  Ala Trp Lys Ser Asp  Phe Val Ser Glu Ser  Glu Glu Ala 
    1040                 1045                 1050             


Ala Cys  Arg Ile Ser Glu Leu  Lys Ser Tyr Leu Ser  Arg Gln Lys 
    1055                 1060                 1065             


Gly Ile  Thr Cys Arg Arg Tyr  Pro Cys Glu Trp Gly  Gly Val Ala 
    1070                 1075                 1080             


Ala Gly  Arg Pro Tyr Val Gly  Gly Leu Glu Glu Phe  Gly Gln Leu 
    1085                 1090                 1095             


Val Leu  Gln Asp Val Trp Asn  Met Ile Gln Lys Leu  Tyr Leu Gln 
    1100                 1105                 1110             


Pro Gly  Ala Leu Leu Glu Gln  Pro Val Ser Ile Pro  Asp Asp Asp 
    1115                 1120                 1125             


Leu Val  Gln Ala Thr Phe Gln  Gln Leu Gln Lys Pro  Pro Ser Pro 
    1130                 1135                 1140             


Ala Arg  Pro Arg Leu Leu Gln  Asp Thr Val Gln Gln  Leu Met Leu 
    1145                 1150                 1155             


Pro His  Gly Arg Leu Ser Leu  Val Thr Gly Gln Ser  Gly Gln Gly 
    1160                 1165                 1170             


Lys Thr  Ala Phe Leu Ala Ser  Leu Val Ser Ala Leu  Gln Ala Pro 
    1175                 1180                 1185             


Asp Gly  Ala Lys Val Ala Pro  Leu Val Phe Phe His  Phe Ser Gly 
    1190                 1195                 1200             


Ala Arg  Pro Asp Gln Gly Leu  Ala Leu Thr Leu Leu  Arg Arg Leu 
    1205                 1210                 1215             


Cys Thr  Tyr Leu Arg Gly Gln  Leu Lys Glu Pro Gly  Ala Leu Pro 
    1220                 1225                 1230             


Ser Thr  Tyr Arg Ser Leu Val  Trp Glu Leu Gln Gln  Arg Leu Leu 
    1235                 1240                 1245             


Pro Lys  Ser Ala Glu Ser Leu  His Pro Gly Gln Thr  Gln Val Leu 
    1250                 1255                 1260             


Ile Ile  Asp Gly Ala Asp Arg  Leu Val Asp Gln Asn  Gly Gln Leu 
    1265                 1270                 1275             


Ile Ser  Asp Trp Ile Pro Lys  Lys Leu Pro Arg Cys  Val His Leu 
    1280                 1285                 1290             


Val Leu  Ser Val Ser Ser Asp  Ala Gly Leu Gly Glu  Thr Leu Glu 
    1295                 1300                 1305             


Gln Ser  Gln Gly Ala His Val  Leu Ala Leu Gly Pro  Leu Glu Ala 
    1310                 1315                 1320             


Ser Ala  Arg Ala Arg Leu Val  Arg Glu Glu Leu Ala  Leu Tyr Gly 
    1325                 1330                 1335             


Lys Arg  Leu Glu Glu Ser Pro  Phe Asn Asn Gln Met  Arg Leu Leu 
    1340                 1345                 1350             


Leu Val  Lys Arg Glu Ser Gly  Arg Pro Leu Tyr Leu  Arg Leu Val 
    1355                 1360                 1365             


Thr Asp  His Leu Arg Leu Phe  Thr Leu Tyr Glu Gln  Val Ser Glu 
    1370                 1375                 1380             


Arg Leu  Arg Thr Leu Pro Ala  Thr Val Pro Leu Leu  Leu Gln His 
    1385                 1390                 1395             


Ile Leu  Ser Thr Leu Glu Lys  Glu His Gly Pro Asp  Val Leu Pro 
    1400                 1405                 1410             


Gln Ala  Leu Thr Ala Leu Glu  Val Thr Arg Ser Gly  Leu Thr Val 
    1415                 1420                 1425             


Asp Gln  Leu His Gly Val Leu  Ser Val Trp Arg Thr  Leu Pro Lys 
    1430                 1435                 1440             


Gly Thr  Lys Ser Trp Glu Glu  Ala Val Ala Ala Gly  Asn Ser Gly 
    1445                 1450                 1455             


Asp Pro  Tyr Pro Met Gly Pro  Phe Ala Cys Leu Val  Gln Ser Leu 
    1460                 1465                 1470             


Arg Ser  Leu Leu Gly Glu Gly  Pro Leu Glu Arg Pro  Gly Ala Arg 
    1475                 1480                 1485             


Leu Cys  Leu Pro Asp Gly Pro  Leu Arg Thr Ala Ala  Lys Arg Cys 
    1490                 1495                 1500             


Tyr Gly  Lys Arg Pro Gly Leu  Glu Asp Thr Ala His  Ile Leu Ile 
    1505                 1510                 1515             


Ala Ala  Gln Leu Trp Lys Thr  Cys Asp Ala Asp Ala  Ser Gly Thr 
    1520                 1525                 1530             


Phe Arg  Ser Cys Pro Pro Glu  Ala Leu Gly Asp Leu  Pro Tyr His 
    1535                 1540                 1545             


Leu Leu  Gln Ser Gly Asn Arg  Gly Leu Leu Ser Lys  Phe Leu Thr 
    1550                 1555                 1560             


Asn Leu  His Val Val Ala Ala  His Leu Glu Leu Gly  Leu Val Ser 
    1565                 1570                 1575             


Arg Leu  Leu Glu Ala His Ala  Leu Tyr Ala Ser Ser  Val Pro Lys 
    1580                 1585                 1590             


Glu Glu  Gln Lys Leu Pro Glu  Ala Asp Val Ala Val  Phe Arg Thr 
    1595                 1600                 1605             


Phe Leu  Arg Gln Gln Ala Ser  Ile Leu Ser Gln Tyr  Pro Arg Leu 
    1610                 1615                 1620             


Leu Pro  Gln Gln Ala Ala Asn  Gln Pro Leu Asp Ser  Pro Leu Cys 
    1625                 1630                 1635             


His Gln  Ala Ser Leu Leu Ser  Arg Arg Trp His Leu  Gln His Thr 
    1640                 1645                 1650             


Leu Arg  Trp Leu Asn Lys Pro  Arg Thr Met Lys Asn  Gln Gln Ser 
    1655                 1660                 1665             


Ser Ser  Leu Ser Leu Ala Val  Ser Ser Ser Pro Thr  Ala Val Ala 
    1670                 1675                 1680             


Phe Ser  Thr Asn Gly Gln Arg  Ala Ala Val Gly Thr  Ala Asn Gly 
    1685                 1690                 1695             


Thr Val  Tyr Leu Leu Asp Leu  Arg Thr Trp Gln Glu  Glu Lys Ser 
    1700                 1705                 1710             


Val Val  Ser Gly Cys Asp Gly  Ile Ser Ala Cys Leu  Phe Leu Ser 
    1715                 1720                 1725             


Asp Asp  Thr Leu Phe Leu Thr  Ala Phe Asp Gly Leu  Leu Glu Leu 
    1730                 1735                 1740             


Trp Asp  Leu Gln His Gly Cys  Arg Val Leu Gln Thr  Lys Ala His 
    1745                 1750                 1755             


Gln Tyr  Gln Ile Thr Gly Cys  Cys Leu Ser Pro Asp  Cys Arg Leu 
    1760                 1765                 1770             


Leu Ala  Thr Val Cys Leu Gly  Gly Cys Leu Lys Leu  Trp Asp Thr 
    1775                 1780                 1785             


Val Arg  Gly Gln Leu Ala Phe  Gln His Thr Tyr Pro  Lys Ser Leu 
    1790                 1795                 1800             


Asn Cys  Val Ala Phe His Pro  Glu Gly Gln Val Ile  Ala Thr Gly 
    1805                 1810                 1815             


Ser Trp  Ala Gly Ser Ile Ser  Phe Phe Gln Val Asp  Gly Leu Lys 
    1820                 1825                 1830             


Val Thr  Lys Asp Leu Gly Ala  Pro Gly Ala Ser Ile  Arg Thr Leu 
    1835                 1840                 1845             


Ala Phe  Asn Val Pro Gly Gly  Val Val Ala Val Gly  Arg Leu Asp 
    1850                 1855                 1860             


Ser Met  Val Glu Leu Trp Ala  Trp Arg Glu Gly Ala  Arg Leu Ala 
    1865                 1870                 1875             


Ala Phe  Pro Ala His His Gly  Phe Val Ala Ala Ala  Leu Phe Leu 
    1880                 1885                 1890             


His Ala  Gly Cys Gln Leu Leu  Thr Ala Gly Glu Asp  Gly Lys Val 
    1895                 1900                 1905             


Gln Val  Trp Ser Gly Ser Leu  Gly Arg Pro Arg Gly  His Leu Gly 
    1910                 1915                 1920             


Ser Leu  Ser Leu Ser Pro Ala  Leu Ser Val Ala Leu  Ser Pro Asp 
    1925                 1930                 1935             


Gly Asp  Arg Val Ala Val Gly  Tyr Arg Ala Asp Gly  Ile Arg Ile 
    1940                 1945                 1950             


Tyr Lys  Ile Ser Ser Gly Ser  Gln Gly Ala Gln Gly  Gln Ala Leu 
    1955                 1960                 1965             


Asp Val  Ala Val Ser Ala Leu  Ala Trp Leu Ser Pro  Lys Val Leu 
    1970                 1975                 1980             


Val Ser  Gly Ala Glu Asp Gly  Ser Leu Gln Gly Trp  Ala Leu Lys 
    1985                 1990                 1995             


Glu Cys  Ser Leu Gln Ser Leu  Trp Leu Leu Ser Arg  Phe Gln Lys 
    2000                 2005                 2010             


Pro Val  Leu Gly Leu Ala Thr  Ser Gln Glu Leu Leu  Ala Ser Ala 
    2015                 2020                 2025             


Ser Glu  Asp Phe Thr Val Gln  Leu Trp Pro Arg Gln  Leu Leu Thr 
    2030                 2035                 2040             


Arg Pro  His Lys Ala Glu Asp  Phe Pro Cys Gly Thr  Glu Leu Arg 
    2045                 2050                 2055             


Gly His  Glu Gly Pro Val Ser  Cys Cys Ser Phe Ser  Thr Asp Gly 
    2060                 2065                 2070             


Gly Ser  Leu Ala Thr Gly Gly  Arg Asp Arg Ser Leu  Leu Cys Trp 
    2075                 2080                 2085             


Asp Val  Arg Thr Pro Lys Thr  Pro Val Leu Ile His  Ser Phe Pro 
    2090                 2095                 2100             


Ala Cys  His Arg Asp Trp Val  Thr Gly Cys Ala Trp  Thr Lys Asp 
    2105                 2110                 2115             


Asn Leu  Leu Ile Ser Cys Ser  Ser Asp Gly Ser Val  Gly Leu Trp 
    2120                 2125                 2130             


Asp Pro  Glu Ser Gly Gln Arg  Leu Gly Gln Phe Leu  Gly His Gln 
    2135                 2140                 2145             


Ser Ala  Val Ser Ala Val Ala  Ala Val Glu Glu His  Val Val Ser 
    2150                 2155                 2160             


Val Ser  Arg Asp Gly Thr Leu  Lys Val Trp Asp His  Gln Gly Val 
    2165                 2170                 2175             


Glu Leu  Thr Ser Ile Pro Ala  His Ser Gly Pro Ile  Ser His Cys 
    2180                 2185                 2190             


Ala Ala  Ala Met Glu Pro Arg  Ala Ala Gly Gln Pro  Gly Ser Glu 
    2195                 2200                 2205             


Leu Leu  Val Val Thr Val Gly  Leu Asp Gly Ala Thr  Arg Leu Trp 
    2210                 2215                 2220             


His Pro  Leu Leu Val Cys Gln  Thr His Thr Leu Leu  Gly His Ser 
    2225                 2230                 2235             


Gly Pro  Val Arg Ala Ala Ala  Val Ser Glu Thr Ser  Gly Leu Met 
    2240                 2245                 2250             


Leu Thr  Ala Ser Glu Asp Gly  Ser Val Arg Leu Trp  Gln Val Pro 
    2255                 2260                 2265             


Lys Glu  Ala Asp Asp Thr Cys  Ile Pro Arg Ser Ser  Ala Ala Val 
    2270                 2275                 2280             


Thr Ala  Val Ala Trp Ala Pro  Asp Gly Ser Met Ala  Val Ser Gly 
    2285                 2290                 2295             


Asn Gln  Ala Gly Glu Leu Ile  Leu Trp Gln Glu Ala  Lys Ala Val 
    2300                 2305                 2310             


Ala Thr  Ala Gln Ala Pro Gly  His Ile Gly Ala Leu  Ile Trp Ser 
    2315                 2320                 2325             


Ser Ala  His Thr Phe Phe Val  Leu Ser Ala Asp Glu  Lys Ile Ser 
    2330                 2335                 2340             


Glu Trp  Gln Val Lys Leu Arg  Lys Gly Ser Ala Pro  Gly Asn Leu 
    2345                 2350                 2355             


Ser Leu  His Leu Asn Arg Ile  Leu Gln Glu Asp Leu  Gly Val Leu 
    2360                 2365                 2370             


Thr Ser  Leu Asp Trp Ala Pro  Asp Gly His Phe Leu  Ile Leu Ala 
    2375                 2380                 2385             


Lys Ala  Asp Leu Lys Leu Leu  Cys Met Lys Pro Gly  Asp Ala Pro 
    2390                 2395                 2400             


Ser Glu  Ile Trp Ser Ser Tyr  Thr Glu Asn Pro Met  Ile Leu Ser 
    2405                 2410                 2415             


Thr His  Lys Glu Tyr Gly Ile  Phe Val Leu Gln Pro  Lys Asp Pro 
    2420                 2425                 2430             


Gly Val  Leu Ser Phe Leu Arg  Gln Lys Glu Ser Gly  Glu Phe Glu 
    2435                 2440                 2445             


Glu Arg  Leu Asn Phe Asp Ile  Asn Leu Glu Asn Pro  Ser Arg Thr 
    2450                 2455                 2460             


Leu Ile  Ser Ile Thr Gln Ala  Lys Pro Glu Ser Glu  Ser Ser Phe 
    2465                 2470                 2475             


Leu Cys  Ala Ser Ser Asp Gly  Ile Leu Trp Asn Leu  Ala Lys Cys 
    2480                 2485                 2490             


Ser Pro  Glu Gly Glu Trp Thr  Thr Gly Asn Met Trp  Gln Lys Lys 
    2495                 2500                 2505             


Ala Asn  Thr Pro Glu Thr Gln  Thr Pro Gly Thr Asp  Pro Ser Thr 
    2510                 2515                 2520             


Cys Arg  Glu Ser Asp Ala Ser  Met Asp Ser Asp Ala  Ser Met Asp 
    2525                 2530                 2535             


Ser Glu  Pro Thr Pro His Leu  Lys Thr Arg Gln Arg  Arg Lys Ile 
    2540                 2545                 2550             


His Ser  Gly Ser Val Thr Ala  Leu His Val Leu Pro  Glu Leu Leu 
    2555                 2560                 2565             


Val Thr  Ala Ser Lys Asp Arg  Asp Val Lys Leu Trp  Glu Arg Pro 
    2570                 2575                 2580             


Ser Met  Gln Leu Leu Gly Leu  Phe Arg Cys Glu Gly  Ser Val Ser 
    2585                 2590                 2595             


Cys Leu  Glu Pro Trp Leu Gly  Ala Asn Ser Thr Leu  Gln Leu Ala 
    2600                 2605                 2610             


Val Gly  Asp Val Gln Gly Asn  Val Tyr Phe Leu Asn  Trp Glu 
    2615                 2620                 2625         


<210>  11
<211>  7884
<212>  DNA
<213>  Homo sapiens

<400>  11
atggaaaaac tccatgggca tgtgtctgcc catccagaca tcctctcctt ggagaaccgg       60

tgcctggcta tgctccctga cttacagccc ttggagaaac tacatcagca tgtatctacc      120

cactcagata tcctctcctt gaagaaccag tgcctagcca cgcttcctga cctgaagacc      180

atggaaaaac cacatggata tgtgtctgcc cacccagaca tcctctcctt ggagaaccag      240

tgcctggcca cactttctga cctgaagacc atggagaaac cacatggaca tgtttctgcc      300

cacccagaca tcctctcctt ggagaaccgg tgcctggcca ccctccctag tctaaagagc      360

actgtgtctg ccagcccctt gttccagagt ctacagatat ctcacatgac gcaagctgat      420

ttgtaccgtg tgaacaacag caattgcctg ctctctgagc ctccaagttg gagggctcag      480

catttctcta agggactaga cctttcaacc tgccctatag ccctgaaatc catctctgcc      540

acagagacag ctcaggaagc aactttgggt cgttggtttg attcagaaga gaagaaaggg      600

gcagagaccc aaatgccttc ttatagtctg agcttgggag aggaggagga ggtggaggat      660

ctggccgtga agctcacctc tggagactct gaatctcatc cagagcctac tgaccatgtc      720

cttcaggaaa agaagatggc tctactgagc ttgctgtgct ctactctggt ctcagaagta      780

aacatgaaca atacatctga ccccaccctg gctgccattt ttgaaatctg tcgtgaactt      840

gccctcctgg agcctgagtt tatcctcaag gcatctttgt atgccaggca gcagctgaac      900

gtccggaatg tggccaataa catcttggcc attgctgctt tcttgccggc gtgtcgcccc      960

cacctgcgac gatatttctg tgccattgtc cagctgcctt ctgactggat ccaggtggct     1020

gagctttacc agagcctggc tgagggagat aagaataagc tggtgcccct gcccgcctgt     1080

ctccgtactg ccatgacgga caaatttgcc cagtttgacg agtaccagct ggctaagtac     1140

aaccctcgga agcaccgggc caagagacac ccccgccggc caccccgctc tccagggatg     1200

gagcctccat tttctcacag atgttttcca aggtacatag ggtttctcag agaagagcag     1260

agaaagtttg agaaggccgg tgatacagtg tcagagaaaa agaatcctcc aaggttcacc     1320

ctgaagaagc tggttcagcg actgcacatc cacaagcctg cccagcacgt tcaagccctg     1380

ctgggttaca gatacccctc caacctacag ctcttttctc gaagtcgcct tcctgggcct     1440

tgggattcta gcagagctgg gaagaggatg aagctgtcta ggccagagac ctgggagcgg     1500

gagctgagcc tacgggggaa caaagcgtcg gtctgggagg aactcattga aaatgggaag     1560

cttcccttca tggccatgct tcggaacctg tgcaacctgc tgcgggttgg aatcagttcc     1620

cgccaccatg agctcattct ccagagactc cagcatggga agtcggtgat ccacagtcgg     1680

cagtttccat tcagatttct taacgcccat gatgccattg atgccctcga ggctcaactc     1740

agaaatcaag cattgccctt tccttcgaat ataacactga tgaggcggat actaactaga     1800

aatgaaaaga accgtcccag gcggaggttt ctttgccacc taagccgtca gcagcttcgt     1860

atggcaatga ggatacctgt gttgtatgag cagctcaaga gggagaagct gagagtacac     1920

aaggccagac agtggaaata tgatggtgag atgctgaaca ggtaccgaca ggccctagag     1980

acagctgtga acctctctgt gaagcacagc ctgcccctgc tgccaggccg cactgtcttg     2040

gtctatctga cagatgctaa tgcagacagg ctctgtccaa agagcaaccc acaagggccc     2100

ccgctgaact atgcactgct gttgattggg atgatgatca cgagggcgga gcaggtggac     2160

gtcgtgctgt gtggaggtga cactctgaag actgcagtgc ttaaggcaga agaaggcatc     2220

ctgaagactg ccatcaagct ccaggctcaa gtccaggagt ttgatgaaaa tgatggatgg     2280

tccctgaata cttttgggaa atacctgctg tctctggctg gccaaagggt tcctgtggac     2340

agggtcatcc tccttggcca aagcatggat gatggaatga taaatgtggc caaacagctt     2400

tactggcagc gtgtgaattc caagtgcctc tttgttggta tcctcctaag aagggtacaa     2460

tacctgtcaa cagatttgaa tcccaatgat gtgacactct caggctgtac tgatgcgata     2520

ctgaagttca ttgcagagca tggggcctcc catcttctgg aacatgtggg ccaaatggac     2580

aaaatattca agattccacc acccccagga aagacagggg tccagtctct ccggccactg     2640

gaagaggaca ctccaagccc cttggctcct gtttcccagc aaggatggcg cagcatccgg     2700

cttttcattt catccacttt ccgagacatg cacggggagc gggacctgct gctgaggtct     2760

gtgctgccag cactgcaggc ccgagcggcc cctcaccgta tcagccttca cggaatcgac     2820

ctccgctggg gcgtcactga ggaggagacc cgtaggaaca gacaactgga agtgtgcctt     2880

ggggaggtgg agaacgcaca gctgtttgtg gggattctgg gctcccgtta tggatacatt     2940

ccccccagct acaaccttcc tgaccatcca cacttccact gggcccagca gtacccttca     3000

gggcgctctg tgacagagat ggaggtgatg cagttcctga accggaacca acgtctgcag     3060

ccctctgccc aagctctcat ctacttccgg gattccagct tcctcagctc tgtgccagat     3120

gcctggaaat ctgactttgt ttctgagtct gaagaggccg catgtcggat ctcagaactg     3180

aagagctacc taagcagaca gaaagggata acctgccgca gatacccctg tgagtggggg     3240

ggtgtggcag ctggccggcc ctatgttggc gggctggagg agtttgggca gttggttctg     3300

caggatgtat ggaatatgat ccagaagctc tacctgcagc ctggggccct gctggagcag     3360

ccagtgtcca tcccagacga tgacttggtc caggccacct tccagcagct gcagaagcca     3420

ccgagtcctg cccggccacg ccttcttcag gacacagtgc aacagctgat gctgccccac     3480

ggaaggctga gcctggtgac ggggcagtca ggacagggca agacagcctt cctggcatct     3540

cttgtgtcag ccctgcaggc tcctgatggg gccaaggtgg caccattagt cttcttccac     3600

ttttctgggg ctcgtcctga ccagggtctt gccctcactc tgctcagacg cctctgtacc     3660

tatctgcgtg gccaactaaa agagccaggt gccctcccca gcacctaccg aagcctggtg     3720

tgggagctgc agcagaggct gctgcccaag tctgctgagt ccctgcatcc tggccagacc     3780

caggtcctga tcatcgatgg ggctgatagg ttagtggacc agaatgggca gctgatttca     3840

gactggatcc caaagaagct tccccggtgt gtacacctgg tgctgagtgt gtctagtgat     3900

gcaggcctag gggagaccct tgagcagagc cagggtgccc acgtgctggc cttggggcct     3960

ctggaggcct ctgctcgggc ccggctggtg agagaggagc tggccctgta cgggaagcgg     4020

ctggaggagt caccatttaa caaccagatg cgactgctgc tggtgaagcg ggaatcaggc     4080

cggccgctct acctgcgctt ggtcaccgat cacctgaggc tcttcacgct gtatgagcag     4140

gtgtctgaga gactccggac cctgcctgcc actgtccccc tgctgctgca gcacatcctg     4200

agcacactgg agaaggagca cgggcctgat gtccttcccc aggccttgac tgccctagaa     4260

gtcacacgga gtggtttgac tgtggaccag ctgcacggag tgctgagtgt gtggcggaca     4320

ctaccgaagg ggactaagag ctgggaagaa gcagtggctg ctggtaacag tggagacccc     4380

taccccatgg gcccgtttgc ctgcctcgtc cagagtctgc gcagtttgct aggggagggc     4440

cctctggagc gccctggtgc ccggctgtgc ctccctgatg ggcccctgag aacagcagct     4500

aaacgttgct atgggaagag gccagggcta gaggacacgg cacacatcct cattgcagct     4560

cagctctgga agacatgtga cgctgatgcc tcaggcacct tccgaagttg ccctcctgag     4620

gctctgggag acctgcctta ccacctgctc cagagcggga accgtggact tctttcgaag     4680

ttccttacca acctccatgt ggtggctgca cacttggaat tgggtctggt ctctcggctc     4740

ttggaggccc atgccctcta tgcttcttca gtccccaaag aggaacaaaa gctccccgag     4800

gctgacgttg cagtgtttcg caccttcctg aggcagcagg cttcaatcct cagccagtac     4860

ccccggctcc tgccccagca ggcagccaac cagcccctgg actcacctct ttgccaccaa     4920

gcctcgctgc tctcccggag atggcacctc caacacacac tacgatggct taataaaccc     4980

cggaccatga aaaatcagca aagctccagc ctgtctctgg cagtttcctc atcccctact     5040

gctgtggcct tctccaccaa tgggcaaaga gcagctgtgg gcactgccaa tgggacagtt     5100

tacctgttgg acctgagaac ttggcaggag gagaagtctg tggtgagtgg ctgtgatgga     5160

atctctgctt gtttgttcct ctccgatgat acactctttc ttactgcctt cgacgggctc     5220

ctggagctct gggacctgca gcatggttgt cgggtgctgc agactaaggc tcaccagtac     5280

caaatcactg gctgctgcct gagcccagac tgccggctgc tagccaccgt gtgcttggga     5340

ggatgcctaa agctgtggga cacagtccgt gggcagctgg ccttccagca cacctacccc     5400

aagtccctga actgtgttgc cttccaccca gaggggcagg taatagccac aggcagctgg     5460

gctggcagca tcagcttctt ccaggtggat gggctcaaag tcaccaagga cctgggggca     5520

cccggagcct ctatccgtac cttggccttc aatgtgcctg ggggggttgt ggctgtgggc     5580

cggctggaca gtatggtgga gctgtgggcc tggcgagaag gggcacggct ggctgccttc     5640

cctgcccacc atggctttgt tgctgctgcg cttttcctgc atgcgggttg ccagttactg     5700

acggctggag aggatggcaa ggttcaggtg tggtcagggt ctctgggtcg gccccgtggg     5760

cacctgggtt ccctttctct ctctcctgcc ctctctgtgg cactcagccc agatggtgat     5820

cgggtggctg ttggatatcg agcggatggc attaggatct acaaaatctc ttcaggttcc     5880

cagggggctc agggtcaggc actggatgtg gcagtgtccg ccctggcctg gctaagcccc     5940

aaggtattgg tgagtggtgc agaagatggg tccttgcagg gctgggcact caaggaatgc     6000

tcccttcagt ccctctggct cctgtccaga ttccagaagc ctgtgctagg actggccact     6060

tcccaggagc tcttggcttc tgcctcagag gatttcacag tgcagctgtg gccaaggcag     6120

ctgctgacgc ggccacacaa ggcagaagac tttccctgtg gcactgagct gcggggacat     6180

gagggccctg tgagctgctg tagtttcagc actgatggag gcagcctggc caccgggggc     6240

cgggatcgga gtctcctctg ctgggacgtg aggacaccca aaacccctgt tttgatccac     6300

tccttccctg cctgtcaccg tgactgggtc actggctgtg cctggaccaa agataaccta     6360

ctgatatcct gctccagtga tggctctgtg gggctctggg acccagagtc aggacagcgg     6420

cttggtcagt tcctgggtca tcagagtgct gtgagcgctg tggcagctgt ggaggagcac     6480

gtggtgtctg tgagccggga tgggaccttg aaagtgtggg accatcaagg cgtggagctg     6540

accagcatcc ctgctcactc aggacccatt agccactgtg cagctgccat ggagccccgt     6600

gcagctggac agcctgggtc agagcttctg gtggtaaccg tcgggctaga tggggccaca     6660

cggttatggc atccactctt ggtgtgccaa acccacaccc tcctgggaca cagcggccca     6720

gtccgtgctg ctgctgtttc agaaacctca ggcctcatgc tgaccgcctc tgaggatggt     6780

tctgtacggc tctggcaggt tcctaaggaa gcagatgaca catgtatacc aaggagttct     6840

gcagccgtca ctgctgtggc ttgggcacca gatggttcca tggcagtatc tggaaatcaa     6900

gctggggaac taatcttgtg gcaggaagct aaggctgtgg ccacagcaca ggctccaggc     6960

cacattggtg ctctgatctg gtcctcggca cacacctttt ttgtcctcag tgctgatgag     7020

aaaatcagcg agtggcaagt gaaactgcgg aagggttcgg cacccggaaa tttgagtctt     7080

cacctgaacc gaattctaca ggaggactta ggggtgctga caagtctgga ttgggctcct     7140

gatggtcact ttctcatctt ggccaaagca gatttgaagt tactttgcat gaagccaggg     7200

gatgctccat ctgaaatctg gagcagctat acagaaaatc ctatgatatt gtccacccac     7260

aaggagtatg gcatatttgt cctgcagccc aaggatcctg gagttctttc tttcttgagg     7320

caaaaggaat caggagagtt tgaagagagg ctgaactttg atataaactt agagaatcct     7380

agtaggaccc taatatcgat aactcaagcc aaacctgaat ctgagtcctc atttttgtgt     7440

gccagctctg atgggatcct atggaacctg gccaaatgca gcccagaagg agaatggacc     7500

acaggtaaca tgtggcagaa aaaagcaaac actccagaaa cccaaactcc agggacagac     7560

ccatctacct gcagggaatc tgatgccagc atggatagtg atgccagcat ggatagtgag     7620

ccaacaccac atctaaagac acggcagcgt agaaagattc actcgggctc tgtcacagcc     7680

ctccatgtgc tacctgagtt gctggtgaca gcttcgaagg acagagatgt taagctatgg     7740

gagagaccca gtatgcagct gctgggcctg ttccgatgcg aagggtcagt gagctgcctg     7800

gaaccttggc tgggcgctaa ctccaccctg cagcttgccg tgggagacgt gcagggcaat     7860

gtgtactttc tgaattggga atga                                            7884


<210>  12
<211>  98
<212>  RNA
<213>  Homo sapiens

<400>  12
ggcuggcuuu agcucagcgg uuacuucgac aguucuuuaa uugaaacaag caaccugucu       60

ggguuguucg agacccgcgg gcgcucucca guccuuuu                               98


<210>  13
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  13
ggcuggcuuu agcucagcgg uuacuucgag uacauuguaa ccaccucucu gggugguucg       60

agacccgcgg gugcuuucca gcucuuuu                                          88


<210>  14
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  14
ggcuggcuuu agcucagcgg uuacuucgcg ugucaucaaa ccaccucucu ggguuguucg       60

agacccgcgg gcgcucucca gcccucuu                                          88


<210>  15
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Asn Leu Arg Leu Pro Met Ala Ser Ala Leu Pro Glu Ala Leu Cys 
1               5                   10                  15      


Ser Gln Ser Arg Thr Thr Pro Val Asp Leu Cys Leu Leu Glu Glu Ser 
            20                  25                  30          


Val Gly Ser Leu Glu Gly Ser Arg Cys Pro Val Phe Ala Phe Gln Ser 
        35                  40                  45              


Ser Asp Thr Glu Ser Asp Glu Leu Ser Glu Val Leu Gln Asp Ser Cys 
    50                  55                  60                  


Phe Leu Gln Ile Lys Cys Asp Thr Lys Asp Asp Ser Ile Pro Cys Phe 
65                  70                  75                  80  


Leu Glu Leu Lys Glu Glu Asp Glu Ile Val Cys Thr Gln His Trp Gln 
                85                  90                  95      


Asp Ala Val Pro Trp Thr Glu Leu Leu Ser Leu Gln Thr Glu Asp Gly 
            100                 105                 110         


Phe Trp Lys Leu Thr Pro Glu Leu Gly Leu Ile Leu Asn Leu Asn Thr 
        115                 120                 125             


Asn Gly Leu His Ser Phe Leu Lys Gln Lys Gly Ile Gln Ser Leu Gly 
    130                 135                 140                 


Val Lys Gly Arg Glu Cys Leu Leu Asp Leu Ile Ala Thr Met Leu Val 
145                 150                 155                 160 


Leu Gln Phe Ile Arg Thr Arg Leu Glu Lys Glu Gly Ile Val Phe Lys 
                165                 170                 175     


Ser Leu Met Lys Met Asp Asp Pro Ser Ile Ser Arg Asn Ile Pro Trp 
            180                 185                 190         


Ala Phe Glu Ala Ile Lys Gln Ala Ser Glu Trp Val Arg Arg Thr Glu 
        195                 200                 205             


Gly Gln Tyr Pro Ser Ile Cys Pro Arg Leu Glu Leu Gly Asn Asp Trp 
    210                 215                 220                 


Asp Ser Ala Thr Lys Gln Leu Leu Gly Leu Gln Pro Ile Ser Thr Val 
225                 230                 235                 240 


Ser Pro Leu His Arg Val Leu His Tyr Ser Gln Gly 
                245                 250         


<210>  16
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu 
1               5                   10                  15      


Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Gln Leu 
            20                  25                  30      


<210>  17
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A2-29 from Hepatitis C Virus as attached to MVP

<400>  17

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr 
            20                  25                  30      


<210>  18
<211>  33
<212>  PRT
<213>  Staphylococcus aureus

<400>  18

Phe Asn Met Gln Gln Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp 
            20                  25                  30          


Asp 
    


<210>  19
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  19

Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu Ser Asp Phe Lys Thr 
1               5                   10                  15      


Trp Leu Lys Ala 
            20  


<210>  20
<211>  28
<212>  PRT
<213>  Hepatitis C virus

<400>  20

Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu Ser 
1               5                   10                  15      


Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro 
            20                  25              


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer based on based on Hepatitis C Virus and Rattus 
       norvegicus

<400>  21
gaattcacca tggccggttc ctggc                                             25


<210>  22
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer based on Hepatitis C Virus and Rattus norvegicus

<400>  22
ccttgctcac ccatggttgg catgag                                            26


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A-rMVP partial sequence based on Hepatitis C Virus and Rattus 
       norvegicus

<400>  23

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met 
            20                  25                  30          


Ala Thr Glu Glu 
        35      


<210>  24
<211>  861
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Met Ala Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly 
225                 230                 235                 240 


Val Leu His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro 
        435                 440                 445             


Ser Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met 
        595                 600                 605             


Ser Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Asn Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met 
        755                 760                 765             


Glu Leu Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys 
    850                 855                 860     


<210>  25
<211>  2583
<212>  DNA
<213>  Rattus norvegicus

<400>  25
atggcaactg aagaggccat catccgcatc cccccatacc actacatcca tgtgctggac       60

cagaacagta atgtgtcccg tgtggaggtt ggaccaaaga cctacatccg gcaggacaat      120

gagagggtac tgtttgcccc agttcgcatg gtgaccgtcc ccccacgcca ctactgcata      180

gtggccaacc ctgtgtcccg ggacacccag agttctgtgt tatttgacat cacaggacaa      240

gtccgactcc ggcacgctga ccaggagatc cgactagccc aggacccctt ccccctgtat      300

ccaggggagg tgctggaaaa ggacatcacc ccactgcagg tggttctgcc caacacagca      360

ctgcatctta aggcgttgct ggactttgag gataagaatg gagacaaggt catggcagga      420

gacgagtggc tatttgaggg acctggcacc tacatcccac agaaggaagt ggaagtcgtg      480

gagatcattc aggccacagt catcaaacag aaccaagcac tgcggctaag ggcccgaaag      540

gagtgctttg accgggaggg caaggggcgc gtgacaggtg aggagtggct ggtccgatcc      600

gtgggggctt acctcccagc tgtctttgaa gaggtgctgg atctggtgga tgctgtgatc      660

cttacagaaa agactgccct gcacctccgg gctctgcaga acttcaggga ccttcgggga      720

gtgctccacc gcaccgggga ggaatggtta gtgacagtgc aggacacaga agcccatgtt      780

ccagatgtct atgaggaggt gcttggggta gtacccatca ccaccctggg acctcgacac      840

tactgtgtca ttcttgaccc aatgggacca gacggcaaga accagctggg acaaaagcgt      900

gttgtcaagg gagagaagtc ctttttcctc cagccaggag agaggctgga gcgaggcatc      960

caggatgtgt atgtgctgtc agagcagcag gggctgctac tgaaggcact gcagcccctg     1020

gaggagggag agagcgagga gaaggtctcc catcaggccg gagactgctg gctcatccgt     1080

gggcccctgg agtatgtgcc atctgcaaaa gtggaggtgg tggaggagcg tcaggctatc     1140

cctctggacc aaaatgaggg catctatgtg caggatgtca agacggggaa ggtgcgggct     1200

gtgattggaa gcacctacat gctgactcag gatgaagtcc tgtgggaaaa ggagctgcct     1260

tctggggtgg aggagctgct gaacttgggg catgaccctc tggcagacag gggtcagaag     1320

ggcacagcca agccccttca gccctcagct ccaaggaaca agacccgagt ggtcagctac     1380

cgtgtcccgc acaatgcagc ggtgcaggtc tatgactaca gagccaagag agcccgtgtg     1440

gtctttgggc ccgagctagt gacactggat cctgaggagc agttcacagt attgtccctt     1500

tctgccgggc gacccaagcg tcctcatgcc cgccgtgcac tctgcctact gctgggacct     1560

gatttcttta ctgatgtcat caccatcgaa actgcagatc atgccaggtt gcagctgcag     1620

cttgcctaca actggcactt tgaactgaag aaccggaatg accctgcaga ggcagccaag     1680

cttttctccg tgcctgactt cgtgggtgac gcctgcaagg ccattgcatc ccgagtccgg     1740

ggggctgtag cctctgtcac ctttgatgac ttccataaaa actcagcccg gatcattcga     1800

atggctgttt ttggctttga gatgtctgaa gacacaggtc ctgatggcac actcctgccc     1860

aaggctcgag accaggcagt ctttccccaa aacgggctgg tagtcagcag tgtggatgtg     1920

cagtcagtgg agcccgtgga ccagaggacc cgggatgccc ttcagcgcag cgttcagctg     1980

gccatcgaaa ttaccaccaa ctcccaggag gcagcagcca agcacgaggc tcagagactg     2040

gaacaggaag cccgtggtcg gcttgagagg cagaagatct tggaccagtc agaagctgaa     2100

aaagcccgca aggaactctt ggagcttgag gctatgagca tggctgtgga gagcacgggt     2160

aatgccaaag cagaggctga gtcccgtgca gaggcagcga ggatcgaagg agaaggctct     2220

gtgctgcagg ccaagctcaa ggcacaggcg ctagccattg agacggaggc tgagttggag     2280

cgagtaaaga aagtacgaga gatggaactg atctatgccc gggcccagtt ggagctggag     2340

gtgagcaagg cgcagcagct tgccaatgtg gaggcaaaga agttcaagga gatgacagag     2400

gcactgggcc ccggcaccat cagggacctg gctgtggccg ggccagagat gcaggtgaaa     2460

cttctccagt ccctgggcct gaaatccact ctcatcaccg atggctcgtc tcccatcaac     2520

ctcttcagca cagccttcgg gttgctgggg ctggggtctg atggtcagcc gccagcacag     2580

aag                                                                   2583


<210>  26
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A-rMVP fusion protein based on Hepatitis C Virus and Rattus 
       norvegicus

<400>  26

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met 
            20                  25                  30          


Ala Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His 
        35                  40                  45              


Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys 
    50                  55                  60                  


Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg 
65                  70                  75                  80  


Met Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val 
                85                  90                  95      


Ser Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val 
            100                 105                 110         


Arg Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe 
        115                 120                 125             


Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln 
    130                 135                 140                 


Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe 
145                 150                 155                 160 


Glu Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe 
                165                 170                 175     


Glu Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu 
            180                 185                 190         


Ile Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg 
        195                 200                 205             


Ala Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly 
    210                 215                 220                 


Glu Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe 
225                 230                 235                 240 


Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr 
                245                 250                 255     


Ala Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val 
            260                 265                 270         


Leu His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu 
        275                 280                 285             


Ala His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile 
    290                 295                 300                 


Thr Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly 
305                 310                 315                 320 


Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu 
                325                 330                 335     


Lys Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln 
            340                 345                 350         


Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu 
        355                 360                 365             


Gln Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala 
    370                 375                 380                 


Gly Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala 
385                 390                 395                 400 


Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn 
                405                 410                 415     


Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val 
            420                 425                 430         


Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys 
        435                 440                 445             


Glu Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro 
    450                 455                 460                 


Leu Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser 
465                 470                 475                 480 


Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn 
                485                 490                 495     


Ala Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val 
            500                 505                 510         


Phe Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val 
        515                 520                 525             


Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala 
    530                 535                 540                 


Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile 
545                 550                 555                 560 


Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp 
                565                 570                 575     


His Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu 
            580                 585                 590         


Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser 
        595                 600                 605             


Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys 
    610                 615                 620                 


Asn Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser 
625                 630                 635                 640 


Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln 
                645                 650                 655     


Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln 
            660                 665                 670         


Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser 
        675                 680                 685             


Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala 
    690                 695                 700                 


Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu 
705                 710                 715                 720 


Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu 
                725                 730                 735     


Leu Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn 
            740                 745                 750         


Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly 
        755                 760                 765             


Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile 
    770                 775                 780                 


Glu Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu 
785                 790                 795                 800 


Leu Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln 
                805                 810                 815     


Gln Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala 
            820                 825                 830         


Leu Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met 
        835                 840                 845             


Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr 
    850                 855                 860                 


Asp Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu 
865                 870                 875                 880 


Gly Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys 
                885                 890         


<210>  27
<211>  2679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NS5A-rMVP cDNA based on Hepatitis C Virus and Rattus norvegicus

<400>  27
atggccggtt cctggctaag ggacatctgg gactggatat gcgaggtgct gagcgacttt       60

aagacctggc tgaaagccaa gctcatgcca accatggcaa ctgaagaggc catcatccgc      120

atccccccat accactacat ccatgtgctg gaccagaaca gtaatgtgtc ccgtgtggag      180

gttggaccaa agacctacat ccggcaggac aatgagaggg tactgtttgc cccagttcgc      240

atggtgaccg tccccccacg ccactactgc atagtggcca accctgtgtc ccgggacacc      300

cagagttctg tgttatttga catcacagga caagtccgac tccggcacgc tgaccaggag      360

atccgactag cccaggaccc cttccccctg tatccagggg aggtgctgga aaaggacatc      420

accccactgc aggtggttct gcccaacaca gcactgcatc ttaaggcgtt gctggacttt      480

gaggataaga atggagacaa ggtcatggca ggagacgagt ggctatttga gggacctggc      540

acctacatcc cacagaagga agtggaagtc gtggagatca ttcaggccac agtcatcaaa      600

cagaaccaag cactgcggct aagggcccga aaggagtgct ttgaccggga gggcaagggg      660

cgcgtgacag gtgaggagtg gctggtccga tccgtggggg cttacctccc agctgtcttt      720

gaagaggtgc tggatctggt ggatgctgtg atccttacag aaaagactgc cctgcacctc      780

cgggctctgc agaacttcag ggaccttcgg ggagtgctcc accgcaccgg ggaggaatgg      840

ttagtgacag tgcaggacac agaagcccat gttccagatg tctatgagga ggtgcttggg      900

gtagtaccca tcaccaccct gggacctcga cactactgtg tcattcttga cccaatggga      960

ccagacggca agaaccagct gggacaaaag cgtgttgtca agggagagaa gtcctttttc     1020

ctccagccag gagagaggct ggagcgaggc atccaggatg tgtatgtgct gtcagagcag     1080

caggggctgc tactgaaggc actgcagccc ctggaggagg gagagagcga ggagaaggtc     1140

tcccatcagg ccggagactg ctggctcatc cgtgggcccc tggagtatgt gccatctgca     1200

aaagtggagg tggtggagga gcgtcaggct atccctctgg accaaaatga gggcatctat     1260

gtgcaggatg tcaagacggg gaaggtgcgg gctgtgattg gaagcaccta catgctgact     1320

caggatgaag tcctgtggga aaaggagctg ccttctgggg tggaggagct gctgaacttg     1380

gggcatgacc ctctggcaga caggggtcag aagggcacag ccaagcccct tcagccctca     1440

gctccaagga acaagacccg agtggtcagc taccgtgtcc cgcacaatgc agcggtgcag     1500

gtctatgact acagagccaa gagagcccgt gtggtctttg ggcccgagct agtgacactg     1560

gatcctgagg agcagttcac agtattgtcc ctttctgccg ggcgacccaa gcgtcctcat     1620

gcccgccgtg cactctgcct actgctggga cctgatttct ttactgatgt catcaccatc     1680

gaaactgcag atcatgccag gttgcagctg cagcttgcct acaactggca ctttgaactg     1740

aagaaccgga atgaccctgc agaggcagcc aagcttttct ccgtgcctga cttcgtgggt     1800

gacgcctgca aggccattgc atcccgagtc cggggggctg tagcctctgt cacctttgat     1860

gacttccata aaaactcagc ccggatcatt cgaatggctg tttttggctt tgagatgtct     1920

gaagacacag gtcctgatgg cacactcctg cccaaggctc gagaccaggc agtctttccc     1980

caaaacgggc tggtagtcag cagtgtggat gtgcagtcag tggagcccgt ggaccagagg     2040

acccgggatg cccttcagcg cagcgttcag ctggccatcg aaattaccac caactcccag     2100

gaggcagcag ccaagcacga ggctcagaga ctggaacagg aagcccgtgg tcggcttgag     2160

aggcagaaga tcttggacca gtcagaagct gaaaaagccc gcaaggaact cttggagctt     2220

gaggctatga gcatggctgt ggagagcacg ggtaatgcca aagcagaggc tgagtcccgt     2280

gcagaggcag cgaggatcga aggagaaggc tctgtgctgc aggccaagct caaggcacag     2340

gcgctagcca ttgagacgga ggctgagttg gagcgagtaa agaaagtacg agagatggaa     2400

ctgatctatg cccgggccca gttggagctg gaggtgagca aggcgcagca gcttgccaat     2460

gtggaggcaa agaagttcaa ggagatgaca gaggcactgg gccccggcac catcagggac     2520

ctggctgtgg ccgggccaga gatgcaggtg aaacttctcc agtccctggg cctgaaatcc     2580

actctcatca ccgatggctc gtctcccatc aacctcttca gcacagcctt cgggttgctg     2640

gggctggggt ctgatggtca gccgccagca cagaagtga                            2679


<210>  28
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A-NS5A-rMVP fusion protein based on Hepatitis C Virus and 
       Rattus norvegicus

<400>  28

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met 
            20                  25                  30          


Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu 
        35                  40                  45              


Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met Ala 
    50                  55                  60                  


Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His Val 
65                  70                  75                  80  


Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys Thr 
                85                  90                  95      


Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg Met 
            100                 105                 110         


Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val Ser 
        115                 120                 125             


Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val Arg 
    130                 135                 140                 


Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe Pro 
145                 150                 155                 160 


Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln Val 
                165                 170                 175     


Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe Glu 
            180                 185                 190         


Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe Glu 
        195                 200                 205             


Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu Ile 
    210                 215                 220                 


Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg Ala 
225                 230                 235                 240 


Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly Glu 
                245                 250                 255     


Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe Glu 
            260                 265                 270         


Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr Ala 
        275                 280                 285             


Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val Leu 
    290                 295                 300                 


His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu Ala 
305                 310                 315                 320 


His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile Thr 
                325                 330                 335     


Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly Pro 
            340                 345                 350         


Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu Lys 
        355                 360                 365             


Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln Asp 
    370                 375                 380                 


Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu Gln 
385                 390                 395                 400 


Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala Gly 
                405                 410                 415     


Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala Lys 
            420                 425                 430         


Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn Glu 
        435                 440                 445             


Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val Ile 
    450                 455                 460                 


Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys Glu 
465                 470                 475                 480 


Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro Leu 
                485                 490                 495     


Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser Ala 
            500                 505                 510         


Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn Ala 
        515                 520                 525             


Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val Phe 
    530                 535                 540                 


Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val Leu 
545                 550                 555                 560 


Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala Leu 
                565                 570                 575     


Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile Glu 
            580                 585                 590         


Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp His 
        595                 600                 605             


Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu Phe 
    610                 615                 620                 


Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser Arg 
625                 630                 635                 640 


Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys Asn 
                645                 650                 655     


Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser Glu 
            660                 665                 670         


Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln Ala 
        675                 680                 685             


Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln Ser 
    690                 695                 700                 


Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser Val 
705                 710                 715                 720 


Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala Lys 
                725                 730                 735     


His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu Arg 
            740                 745                 750         


Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu Leu 
        755                 760                 765             


Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn Ala 
    770                 775                 780                 


Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly Glu 
785                 790                 795                 800 


Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile Glu 
                805                 810                 815     


Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu Leu 
            820                 825                 830         


Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln Gln 
        835                 840                 845             


Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala Leu 
    850                 855                 860                 


Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met Gln 
865                 870                 875                 880 


Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr Asp 
                885                 890                 895     


Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu Gly 
            900                 905                 910         


Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys 
        915                 920             


<210>  29
<211>  2772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NS5A-NS5A-rMVP cDNA based on Hepatitis C Virus and Rattus 
       norvegicus

<400>  29
atggccggtt cctggctaag ggacatctgg gactggatat gcgaggtgct gagcgacttt       60

aagacctggc tgaaagccaa gctcatgcca accatggccg gttcctggct aagggacatc      120

tgggactgga tatgcgaggt gctgagcgac tttaagacct ggctgaaagc caagctcatg      180

ccaaccatgg caactgaaga ggccatcatc cgcatccccc cataccacta catccatgtg      240

ctggaccaga acagtaatgt gtcccgtgtg gaggttggac caaagaccta catccggcag      300

gacaatgaga gggtactgtt tgccccagtt cgcatggtga ccgtcccccc acgccactac      360

tgcatagtgg ccaaccctgt gtcccgggac acccagagtt ctgtgttatt tgacatcaca      420

ggacaagtcc gactccggca cgctgaccag gagatccgac tagcccagga ccccttcccc      480

ctgtatccag gggaggtgct ggaaaaggac atcaccccac tgcaggtggt tctgcccaac      540

acagcactgc atcttaaggc gttgctggac tttgaggata agaatggaga caaggtcatg      600

gcaggagacg agtggctatt tgagggacct ggcacctaca tcccacagaa ggaagtggaa      660

gtcgtggaga tcattcaggc cacagtcatc aaacagaacc aagcactgcg gctaagggcc      720

cgaaaggagt gctttgaccg ggagggcaag gggcgcgtga caggtgagga gtggctggtc      780

cgatccgtgg gggcttacct cccagctgtc tttgaagagg tgctggatct ggtggatgct      840

gtgatcctta cagaaaagac tgccctgcac ctccgggctc tgcagaactt cagggacctt      900

cggggagtgc tccaccgcac cggggaggaa tggttagtga cagtgcagga cacagaagcc      960

catgttccag atgtctatga ggaggtgctt ggggtagtac ccatcaccac cctgggacct     1020

cgacactact gtgtcattct tgacccaatg ggaccagacg gcaagaacca gctgggacaa     1080

aagcgtgttg tcaagggaga gaagtccttt ttcctccagc caggagagag gctggagcga     1140

ggcatccagg atgtgtatgt gctgtcagag cagcaggggc tgctactgaa ggcactgcag     1200

cccctggagg agggagagag cgaggagaag gtctcccatc aggccggaga ctgctggctc     1260

atccgtgggc ccctggagta tgtgccatct gcaaaagtgg aggtggtgga ggagcgtcag     1320

gctatccctc tggaccaaaa tgagggcatc tatgtgcagg atgtcaagac ggggaaggtg     1380

cgggctgtga ttggaagcac ctacatgctg actcaggatg aagtcctgtg ggaaaaggag     1440

ctgccttctg gggtggagga gctgctgaac ttggggcatg accctctggc agacaggggt     1500

cagaagggca cagccaagcc ccttcagccc tcagctccaa ggaacaagac ccgagtggtc     1560

agctaccgtg tcccgcacaa tgcagcggtg caggtctatg actacagagc caagagagcc     1620

cgtgtggtct ttgggcccga gctagtgaca ctggatcctg aggagcagtt cacagtattg     1680

tccctttctg ccgggcgacc caagcgtcct catgcccgcc gtgcactctg cctactgctg     1740

ggacctgatt tctttactga tgtcatcacc atcgaaactg cagatcatgc caggttgcag     1800

ctgcagcttg cctacaactg gcactttgaa ctgaagaacc ggaatgaccc tgcagaggca     1860

gccaagcttt tctccgtgcc tgacttcgtg ggtgacgcct gcaaggccat tgcatcccga     1920

gtccgggggg ctgtagcctc tgtcaccttt gatgacttcc ataaaaactc agcccggatc     1980

attcgaatgg ctgtttttgg ctttgagatg tctgaagaca caggtcctga tggcacactc     2040

ctgcccaagg ctcgagacca ggcagtcttt ccccaaaacg ggctggtagt cagcagtgtg     2100

gatgtgcagt cagtggagcc cgtggaccag aggacccggg atgcccttca gcgcagcgtt     2160

cagctggcca tcgaaattac caccaactcc caggaggcag cagccaagca cgaggctcag     2220

agactggaac aggaagcccg tggtcggctt gagaggcaga agatcttgga ccagtcagaa     2280

gctgaaaaag cccgcaagga actcttggag cttgaggcta tgagcatggc tgtggagagc     2340

acgggtaatg ccaaagcaga ggctgagtcc cgtgcagagg cagcgaggat cgaaggagaa     2400

ggctctgtgc tgcaggccaa gctcaaggca caggcgctag ccattgagac ggaggctgag     2460

ttggagcgag taaagaaagt acgagagatg gaactgatct atgcccgggc ccagttggag     2520

ctggaggtga gcaaggcgca gcagcttgcc aatgtggagg caaagaagtt caaggagatg     2580

acagaggcac tgggccccgg caccatcagg gacctggctg tggccgggcc agagatgcag     2640

gtgaaacttc tccagtccct gggcctgaaa tccactctca tcaccgatgg ctcgtctccc     2700

atcaacctct tcagcacagc cttcgggttg ctggggctgg ggtctgatgg tcagccgcca     2760

gcacagaagt ga                                                         2772


<210>  30
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A-rMVP-Z domain fusion protein based on Hepatitis C Virus and 
       Rattus norvegicus

<400>  30

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met 
            20                  25                  30          


Ala Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His 
        35                  40                  45              


Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys 
    50                  55                  60                  


Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg 
65                  70                  75                  80  


Met Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val 
                85                  90                  95      


Ser Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val 
            100                 105                 110         


Arg Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe 
        115                 120                 125             


Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln 
    130                 135                 140                 


Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe 
145                 150                 155                 160 


Glu Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe 
                165                 170                 175     


Glu Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu 
            180                 185                 190         


Ile Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg 
        195                 200                 205             


Ala Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly 
    210                 215                 220                 


Glu Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe 
225                 230                 235                 240 


Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr 
                245                 250                 255     


Ala Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val 
            260                 265                 270         


Leu His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu 
        275                 280                 285             


Ala His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile 
    290                 295                 300                 


Thr Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly 
305                 310                 315                 320 


Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu 
                325                 330                 335     


Lys Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln 
            340                 345                 350         


Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu 
        355                 360                 365             


Gln Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala 
    370                 375                 380                 


Gly Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala 
385                 390                 395                 400 


Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn 
                405                 410                 415     


Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val 
            420                 425                 430         


Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys 
        435                 440                 445             


Glu Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro 
    450                 455                 460                 


Leu Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser 
465                 470                 475                 480 


Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn 
                485                 490                 495     


Ala Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val 
            500                 505                 510         


Phe Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val 
        515                 520                 525             


Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala 
    530                 535                 540                 


Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile 
545                 550                 555                 560 


Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp 
                565                 570                 575     


His Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu 
            580                 585                 590         


Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser 
        595                 600                 605             


Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys 
    610                 615                 620                 


Asn Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser 
625                 630                 635                 640 


Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln 
                645                 650                 655     


Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln 
            660                 665                 670         


Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser 
        675                 680                 685             


Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala 
    690                 695                 700                 


Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu 
705                 710                 715                 720 


Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu 
                725                 730                 735     


Leu Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn 
            740                 745                 750         


Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly 
        755                 760                 765             


Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile 
    770                 775                 780                 


Glu Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu 
785                 790                 795                 800 


Leu Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln 
                805                 810                 815     


Gln Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala 
            820                 825                 830         


Leu Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met 
        835                 840                 845             


Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr 
    850                 855                 860                 


Asp Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu 
865                 870                 875                 880 


Gly Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys Phe Asn Met Gln 
                885                 890                 895     


Gln Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro Asn Leu Asn Glu 
            900                 905                 910         


Glu Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp Asp 
        915                 920                 925 


<210>  31
<211>  2778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NS5A-rMVP-Z domain cDNA based on Hepatitis C Virus and Rattus 
       norvegicus

<400>  31
atggccggtt cctggctaag ggacatctgg gactggatat gcgaggtgct gagcgacttt       60

aagacctggc tgaaagccaa gctcatgcca accatggcaa ctgaagaggc catcatccgc      120

atccccccat accactacat ccatgtgctg gaccagaaca gtaatgtgtc ccgtgtggag      180

gttggaccaa agacctacat ccggcaggac aatgagaggg tactgtttgc cccagttcgc      240

atggtgaccg tccccccacg ccactactgc atagtggcca accctgtgtc ccgggacacc      300

cagagttctg tgttatttga catcacagga caagtccgac tccggcacgc tgaccaggag      360

atccgactag cccaggaccc cttccccctg tatccagggg aggtgctgga aaaggacatc      420

accccactgc aggtggttct gcccaacaca gcactgcatc ttaaggcgtt gctggacttt      480

gaggataaga atggagacaa ggtcatggca ggagacgagt ggctatttga gggacctggc      540

acctacatcc cacagaagga agtggaagtc gtggagatca ttcaggccac agtcatcaaa      600

cagaaccaag cactgcggct aagggcccga aaggagtgct ttgaccggga gggcaagggg      660

cgcgtgacag gtgaggagtg gctggtccga tccgtggggg cttacctccc agctgtcttt      720

gaagaggtgc tggatctggt ggatgctgtg atccttacag aaaagactgc cctgcacctc      780

cgggctctgc agaacttcag ggaccttcgg ggagtgctcc accgcaccgg ggaggaatgg      840

ttagtgacag tgcaggacac agaagcccat gttccagatg tctatgagga ggtgcttggg      900

gtagtaccca tcaccaccct gggacctcga cactactgtg tcattcttga cccaatggga      960

ccagacggca agaaccagct gggacaaaag cgtgttgtca agggagagaa gtcctttttc     1020

ctccagccag gagagaggct ggagcgaggc atccaggatg tgtatgtgct gtcagagcag     1080

caggggctgc tactgaaggc actgcagccc ctggaggagg gagagagcga ggagaaggtc     1140

tcccatcagg ccggagactg ctggctcatc cgtgggcccc tggagtatgt gccatctgca     1200

aaagtggagg tggtggagga gcgtcaggct atccctctgg accaaaatga gggcatctat     1260

gtgcaggatg tcaagacggg gaaggtgcgg gctgtgattg gaagcaccta catgctgact     1320

caggatgaag tcctgtggga aaaggagctg ccttctgggg tggaggagct gctgaacttg     1380

gggcatgacc ctctggcaga caggggtcag aagggcacag ccaagcccct tcagccctca     1440

gctccaagga acaagacccg agtggtcagc taccgtgtcc cgcacaatgc agcggtgcag     1500

gtctatgact acagagccaa gagagcccgt gtggtctttg ggcccgagct agtgacactg     1560

gatcctgagg agcagttcac agtattgtcc ctttctgccg ggcgacccaa gcgtcctcat     1620

gcccgccgtg cactctgcct actgctggga cctgatttct ttactgatgt catcaccatc     1680

gaaactgcag atcatgccag gttgcagctg cagcttgcct acaactggca ctttgaactg     1740

aagaaccgga atgaccctgc agaggcagcc aagcttttct ccgtgcctga cttcgtgggt     1800

gacgcctgca aggccattgc atcccgagtc cggggggctg tagcctctgt cacctttgat     1860

gacttccata aaaactcagc ccggatcatt cgaatggctg tttttggctt tgagatgtct     1920

gaagacacag gtcctgatgg cacactcctg cccaaggctc gagaccaggc agtctttccc     1980

caaaacgggc tggtagtcag cagtgtggat gtgcagtcag tggagcccgt ggaccagagg     2040

acccgggatg cccttcagcg cagcgttcag ctggccatcg aaattaccac caactcccag     2100

gaggcagcag ccaagcacga ggctcagaga ctggaacagg aagcccgtgg tcggcttgag     2160

aggcagaaga tcttggacca gtcagaagct gaaaaagccc gcaaggaact cttggagctt     2220

gaggctatga gcatggctgt ggagagcacg ggtaatgcca aagcagaggc tgagtcccgt     2280

gcagaggcag cgaggatcga aggagaaggc tctgtgctgc aggccaagct caaggcacag     2340

gcgctagcca ttgagacgga ggctgagttg gagcgagtaa agaaagtacg agagatggaa     2400

ctgatctatg cccgggccca gttggagctg gaggtgagca aggcgcagca gcttgccaat     2460

gtggaggcaa agaagttcaa ggagatgaca gaggcactgg gccccggcac catcagggac     2520

ctggctgtgg ccgggccaga gatgcaggtg aaacttctcc agtccctggg cctgaaatcc     2580

actctcatca ccgatggctc gtctcccatc aacctcttca gcacagcctt cgggttgctg     2640

gggctggggt ctgatggtca gccgccagca cagaagttta acatgcagca gcagcgccgc     2700

ttttacgagg ccctgcacga ccccaacctg aacgaggagc agcgcaacgc caagattaag     2760

agcattcgcg acgactag                                                   2778


<210>  32
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-rMVP fusion protein based on Rattus norvegicus

<400>  32

Met Ala Gly Cys Gly Cys Pro Cys Gly Cys Gly Ala Met Ala Thr Glu 
1               5                   10                  15      


Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His Val Leu Asp 
            20                  25                  30          


Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys Thr Tyr Ile 
        35                  40                  45              


Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg Met Val Thr 
    50                  55                  60                  


Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val Ser Arg Asp 
65                  70                  75                  80  


Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val Arg Leu Arg 
                85                  90                  95      


His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe Pro Leu Tyr 
            100                 105                 110         


Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln Val Val Leu 
        115                 120                 125             


Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe Glu Asp Lys 
    130                 135                 140                 


Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe Glu Gly Pro 
145                 150                 155                 160 


Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu Ile Ile Gln 
                165                 170                 175     


Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg Ala Arg Lys 
            180                 185                 190         


Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly Glu Glu Trp 
        195                 200                 205             


Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe Glu Glu Val 
    210                 215                 220                 


Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr Ala Leu His 
225                 230                 235                 240 


Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val Leu His Arg 
                245                 250                 255     


Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu Ala His Val 
            260                 265                 270         


Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile Thr Thr Leu 
        275                 280                 285             


Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly Pro Asp Gly 
    290                 295                 300                 


Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu Lys Ser Phe 
305                 310                 315                 320 


Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln Asp Val Tyr 
                325                 330                 335     


Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu Gln Pro Leu 
            340                 345                 350         


Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala Gly Asp Cys 
        355                 360                 365             


Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala Lys Val Glu 
    370                 375                 380                 


Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn Glu Gly Ile 
385                 390                 395                 400 


Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val Ile Gly Ser 
                405                 410                 415     


Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys Glu Leu Pro 
            420                 425                 430         


Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro Leu Ala Asp 
        435                 440                 445             


Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser Ala Pro Arg 
    450                 455                 460                 


Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn Ala Ala Val 
465                 470                 475                 480 


Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val Phe Gly Pro 
                485                 490                 495     


Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val Leu Ser Leu 
            500                 505                 510         


Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala Leu Cys Leu 
        515                 520                 525             


Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile Glu Thr Ala 
    530                 535                 540                 


Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp His Phe Glu 
545                 550                 555                 560 


Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu Phe Ser Val 
                565                 570                 575     


Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser Arg Val Arg 
            580                 585                 590         


Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys Asn Ser Ala 
        595                 600                 605             


Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser Glu Asp Thr 
    610                 615                 620                 


Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln Ala Val Phe 
625                 630                 635                 640 


Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln Ser Val Glu 
                645                 650                 655     


Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser Val Gln Leu 
            660                 665                 670         


Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala Lys His Glu 
        675                 680                 685             


Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu Arg Gln Lys 
    690                 695                 700                 


Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu Leu Leu Glu 
705                 710                 715                 720 


Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn Ala Lys Ala 
                725                 730                 735     


Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly Glu Gly Ser 
            740                 745                 750         


Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile Glu Thr Glu 
        755                 760                 765             


Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu Leu Ile Tyr 
    770                 775                 780                 


Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln Gln Leu Ala 
785                 790                 795                 800 


Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala Leu Gly Pro 
                805                 810                 815     


Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met Gln Val Lys 
            820                 825                 830         


Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr Asp Gly Ser 
        835                 840                 845             


Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu Gly Leu Gly 
    850                 855                 860                 


Ser Asp Gly Gln Pro Pro Ala Gln Lys 
865                 870             


<210>  33
<211>  2847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CP-rMVP cDNA based on Rattus norvegicus

<400>  33
gaattcgcgg ccgcgtcgac tgtggcttgc agctgccagc taccctgcta aatgtttggt       60

gggaaaagct tgggattcac catggcaggc tgcggttgtc catgcggttg tggcgccatg      120

gcaactgaag aggccatcat ccgcatcccc ccataccact acatccatgt gctggaccag      180

aacagtaatg tgtcccgtgt ggaggttgga ccaaagacct acatccggca ggacaatgag      240

agggtactgt ttgccccagt tcgcatggtg accgtccccc cacgccacta ctgcatagtg      300

gccaaccctg tgtcccggga cacccagagt tctgtgttat ttgacatcac aggacaagtc      360

cgactccggc acgctgacca ggagatccga ctagcccagg accccttccc cctgtatcca      420

ggggaggtgc tggaaaagga catcacccca ctgcaggtgg ttctgcccaa cacagcactg      480

catcttaagg cgttgctgga ctttgaggat aagaatggag acaaggtcat ggcaggagac      540

gagtggctat ttgagggacc tggcacctac atcccacaga aggaagtgga agtcgtggag      600

atcattcagg ccacagtcat caaacagaac caagcactgc ggctaagggc ccgaaaggag      660

tgctttgacc gggagggcaa ggggcgcgtg acaggtgagg agtggctggt ccgatccgtg      720

ggggcttacc tcccagctgt ctttgaagag gtgctggatc tggtggatgc tgtgatcctt      780

acagaaaaga ctgccctgca cctccgggct ctgcagaact tcagggacct tcggggagtg      840

ctccaccgca ccggggagga atggttagtg acagtgcagg acacagaagc ccatgttcca      900

gatgtctatg aggaggtgct tggggtagta cccatcacca ccctgggacc tcgacactac      960

tgtgtcattc ttgacccaat gggaccagac ggcaagaacc agctgggaca aaagcgtgtt     1020

gtcaagggag agaagtcctt tttcctccag ccaggagaga ggctggagcg aggcatccag     1080

gatgtgtatg tgctgtcaga gcagcagggg ctgctactga aggcactgca gcccctggag     1140

gagggagaga gcgaggagaa ggtctcccat caggccggag actgctggct catccgtggg     1200

cccctggagt atgtgccatc tgcaaaagtg gaggtggtgg aggagcgtca ggctatccct     1260

ctggaccaaa atgagggcat ctatgtgcag gatgtcaaga cggggaaggt gcgggctgtg     1320

attggaagca cctacatgct gactcaggat gaagtcctgt gggaaaagga gctgccttct     1380

ggggtggagg agctgctgaa cttggggcat gaccctctgg cagacagggg tcagaagggc     1440

acagccaagc cccttcagcc ctcagctcca aggaacaaga cccgagtggt cagctaccgt     1500

gtcccgcaca atgcagcggt gcaggtctat gactacagag ccaagagagc ccgtgtggtc     1560

tttgggcccg agctagtgac actggatcct gaggagcagt tcacagtatt gtccctttct     1620

gccgggcgac ccaagcgtcc tcatgcccgc cgtgcactct gcctactgct gggacctgat     1680

ttctttactg atgtcatcac catcgaaact gcagatcatg ccaggttgca gctgcagctt     1740

gcctacaact ggcactttga actgaagaac cggaatgacc ctgcagaggc agccaagctt     1800

ttctccgtgc ctgacttcgt gggtgacgcc tgcaaggcca ttgcatcccg agtccggggg     1860

gctgtagcct ctgtcacctt tgatgacttc cataaaaact cagcccggat cattcgaatg     1920

gctgtttttg gctttgagat gtctgaagac acaggtcctg atggcacact cctgcccaag     1980

gctcgagacc aggcagtctt tccccaaaac gggctggtag tcagcagtgt ggatgtgcag     2040

tcagtggagc ccgtggacca gaggacccgg gatgcccttc agcgcagcgt tcagctggcc     2100

atcgaaatta ccaccaactc ccaggaggca gcagccaagc acgaggctca gagactggaa     2160

caggaagccc gtggtcggct tgagaggcag aagatcttgg accagtcaga agctgaaaaa     2220

gcccgcaagg aactcttgga gcttgaggct atgagcatgg ctgtggagag cacgggtaat     2280

gccaaagcag aggctgagtc ccgtgcagag gcagcgagga tcgaaggaga aggctctgtg     2340

ctgcaggcca agctcaaggc acaggcgcta gccattgaga cggaggctga gttggagcga     2400

gtaaagaaag tacgagagat ggaactgatc tatgcccggg cccagttgga gctggaggtg     2460

agcaaggcgc agcagcttgc caatgtggag gcaaagaagt tcaaggagat gacagaggca     2520

ctgggccccg gcaccatcag ggacctggct gtggccgggc cagagatgca ggtgaaactt     2580

ctccagtccc tgggcctgaa atccactctc atcaccgatg gctcgtctcc catcaacctc     2640

ttcagcacag ccttcgggtt gctggggctg gggtctgatg gtcagccgcc agcacagaag     2700

tgatccggca gcccggggaa gacttgctct cccaggctct ccgaagcagc catgctgtgc     2760

cttaggtcaa cactgactgc actgacaatg gataaaataa attgacaact gtaaaaaaaa     2820

aaaaaaagtc gacgcggccg cgaattc                                         2847


<210>  34
<211>  905
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP-rMVP-Z domain fusion protein based on Rattus norvegicus

<400>  34

Met Ala Gly Cys Gly Cys Pro Cys Gly Cys Gly Ala Met Ala Thr Glu 
1               5                   10                  15      


Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His Val Leu Asp 
            20                  25                  30          


Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys Thr Tyr Ile 
        35                  40                  45              


Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg Met Val Thr 
    50                  55                  60                  


Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val Ser Arg Asp 
65                  70                  75                  80  


Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val Arg Leu Arg 
                85                  90                  95      


His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe Pro Leu Tyr 
            100                 105                 110         


Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln Val Val Leu 
        115                 120                 125             


Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe Glu Asp Lys 
    130                 135                 140                 


Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe Glu Gly Pro 
145                 150                 155                 160 


Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu Ile Ile Gln 
                165                 170                 175     


Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg Ala Arg Lys 
            180                 185                 190         


Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly Glu Glu Trp 
        195                 200                 205             


Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe Glu Glu Val 
    210                 215                 220                 


Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr Ala Leu His 
225                 230                 235                 240 


Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val Leu His Arg 
                245                 250                 255     


Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu Ala His Val 
            260                 265                 270         


Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile Thr Thr Leu 
        275                 280                 285             


Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly Pro Asp Gly 
    290                 295                 300                 


Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu Lys Ser Phe 
305                 310                 315                 320 


Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln Asp Val Tyr 
                325                 330                 335     


Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu Gln Pro Leu 
            340                 345                 350         


Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala Gly Asp Cys 
        355                 360                 365             


Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala Lys Val Glu 
    370                 375                 380                 


Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn Glu Gly Ile 
385                 390                 395                 400 


Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val Ile Gly Ser 
                405                 410                 415     


Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys Glu Leu Pro 
            420                 425                 430         


Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro Leu Ala Asp 
        435                 440                 445             


Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser Ala Pro Arg 
    450                 455                 460                 


Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn Ala Ala Val 
465                 470                 475                 480 


Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val Phe Gly Pro 
                485                 490                 495     


Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val Leu Ser Leu 
            500                 505                 510         


Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala Leu Cys Leu 
        515                 520                 525             


Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile Glu Thr Ala 
    530                 535                 540                 


Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp His Phe Glu 
545                 550                 555                 560 


Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu Phe Ser Val 
                565                 570                 575     


Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser Arg Val Arg 
            580                 585                 590         


Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys Asn Ser Ala 
        595                 600                 605             


Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser Glu Asp Thr 
    610                 615                 620                 


Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln Ala Val Phe 
625                 630                 635                 640 


Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln Ser Val Glu 
                645                 650                 655     


Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser Val Gln Leu 
            660                 665                 670         


Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala Lys His Glu 
        675                 680                 685             


Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu Arg Gln Lys 
    690                 695                 700                 


Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu Leu Leu Glu 
705                 710                 715                 720 


Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn Ala Lys Ala 
                725                 730                 735     


Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly Glu Gly Ser 
            740                 745                 750         


Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile Glu Thr Glu 
        755                 760                 765             


Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu Leu Ile Tyr 
    770                 775                 780                 


Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln Gln Leu Asn 
785                 790                 795                 800 


Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala Leu Gly Pro Gly 
                805                 810                 815     


Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met Gln Val Lys Leu 
            820                 825                 830         


Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr Asp Gly Ser Ser 
        835                 840                 845             


Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu Gly Leu Gly Ser 
    850                 855                 860                 


Asp Gly Gln Pro Pro Ala Gln Lys Phe Asn Met Gln Gln Gln Arg Arg 
865                 870                 875                 880 


Phe Tyr Glu Ala Leu His Asp Pro Asn Leu Asn Glu Glu Gln Arg Asn 
                885                 890                 895     


Ala Lys Ile Lys Ser Ile Arg Asp Asp 
            900                 905 


<210>  35
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CP-rMVP-Z cDNA based on Rattus norvegicus

<400>  35
gaattcgcgg ccgcgtcgac tgtggcttgc agctgccagc taccctgcta aatgtttggt       60

gggaaaagct tgggattcac catggcaggc tgcggttgtc catgcggttg tggcgccatg      120

gcaactgaag aggccatcat ccgcatcccc ccataccact acatccatgt gctggaccag      180

aacagtaatg tgtcccgtgt ggaggttgga ccaaagacct acatccggca ggacaatgag      240

agggtactgt ttgccccagt tcgcatggtg accgtccccc cacgccacta ctgcatagtg      300

gccaaccctg tgtcccggga cacccagagt tctgtgttat ttgacatcac aggacaagtc      360

cgactccggc acgctgacca ggagatccga ctagcccagg accccttccc cctgtatcca      420

ggggaggtgc tggaaaagga catcacccca ctgcaggtgg ttctgcccaa cacagcactg      480

catcttaagg cgttgctgga ctttgaggat aagaatggag acaaggtcat ggcaggagac      540

gagtggctat ttgagggacc tggcacctac atcccacaga aggaagtgga agtcgtggag      600

atcattcagg ccacagtcat caaacagaac caagcactgc ggctaagggc ccgaaaggag      660

tgctttgacc gggagggcaa ggggcgcgtg acaggtgagg agtggctggt ccgatccgtg      720

ggggcttacc tcccagctgt ctttgaagag gtgctggatc tggtggatgc tgtgatcctt      780

acagaaaaga ctgccctgca cctccgggct ctgcagaact tcagggacct tcggggagtg      840

ctccaccgca ccggggagga atggttagtg acagtgcagg acacagaagc ccatgttcca      900

gatgtctatg aggaggtgct tggggtagta cccatcacca ccctgggacc tcgacactac      960

tgtgtcattc ttgacccaat gggaccagac ggcaagaacc agctgggaca aaagcgtgtt     1020

gtcaagggag agaagtcctt tttcctccag ccaggagaga ggctggagcg aggcatccag     1080

gatgtgtatg tgctgtcaga gcagcagggg ctgctactga aggcactgca gcccctggag     1140

gagggagaga gcgaggagaa ggtctcccat caggccggag actgctggct catccgtggg     1200

cccctggagt atgtgccatc tgcaaaagtg gaggtggtgg aggagcgtca ggctatccct     1260

ctggaccaaa atgagggcat ctatgtgcag gatgtcaaga cggggaaggt gcgggctgtg     1320

attggaagca cctacatgct gactcaggat gaagtcctgt gggaaaagga gctgccttct     1380

ggggtggagg agctgctgaa cttggggcat gaccctctgg cagacagggg tcagaagggc     1440

acagccaagc cccttcagcc ctcagctcca aggaacaaga cccgagtggt cagctaccgt     1500

gtcccgcaca atgcagcggt gcaggtctat gactacagag ccaagagagc ccgtgtggtc     1560

tttgggcccg agctagtgac actggatcct gaggagcagt tcacagtatt gtccctttct     1620

gccgggcgac ccaagcgtcc tcatgcccgc cgtgcactct gcctactgct gggacctgat     1680

ttctttactg atgtcatcac catcgaaact gcagatcatg ccaggttgca gctgcagctt     1740

gcctacaact ggcactttga actgaagaac cggaatgacc ctgcagaggc agccaagctt     1800

ttctccgtgc ctgacttcgt gggtgacgcc tgcaaggcca ttgcatcccg agtccggggg     1860

gctgtagcct ctgtcacctt tgatgacttc cataaaaact cagcccggat cattcgaatg     1920

gctgtttttg gctttgagat gtctgaagac acaggtcctg atggcacact cctgcccaag     1980

gctcgagacc aggcagtctt tccccaaaac gggctggtag tcagcagtgt ggatgtgcag     2040

tcagtggagc ccgtggacca gaggacccgg gatgcccttc agcgcagcgt tcagctggcc     2100

atcgaaatta ccaccaactc ccaggaggca gcagccaagc acgaggctca gagactggaa     2160

caggaagccc gtggtcggct tgagaggcag aagatcttgg accagtcaga agctgaaaaa     2220

gcccgcaagg aactcttgga gcttgaggct atgagcatgg ctgtggagag cacgggtaat     2280

gccaaagcag aggctgagtc ccgtgcagag gcagcgagga tcgaaggaga aggctctgtg     2340

ctgcaggcca agctcaaggc acaggcgcta gccattgaga cggaggctga gttggagcga     2400

gtaaagaaag tacgagagat ggaactgatc tatgcccggg cccagttgga gctggaggtg     2460

agcaaggcgc agcagcttgc caatgtggag gcaaagaagt tcaaggagat gacagaggca     2520

ctgggccccg gcaccatcag ggacctggct gtggccgggc cagagatgca ggtgaaactt     2580

ctccagtccc tgggcctgaa atccactctc atcaccgatg gctcgtctcc catcaacctc     2640

ttcagcacag ccttcgggtt gctggggctg gggtctgatg gtcagccgcc agcacagaag     2700

tttaacatgc agcagcagcg ccgcttttac gaggccctgc acgaccccaa cctgaacgag     2760

gagcagcgca acgccaagat taagagcatt cgcgacgact agggtacc                  2808


<210>  36
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS5A-NS5A-rMVP-Z domain fusion protein based on Hepatitis C Virus
       and Rattus norvegicus

<400>  36

Met Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 
1               5                   10                  15      


Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met 
            20                  25                  30          


Ala Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu 
        35                  40                  45              


Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Thr Met Ala 
    50                  55                  60                  


Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile His Val 
65                  70                  75                  80  


Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro Lys Thr 
                85                  90                  95      


Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val Arg Met 
            100                 105                 110         


Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro Val Ser 
        115                 120                 125             


Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln Val Arg 
    130                 135                 140                 


Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro Phe Pro 
145                 150                 155                 160 


Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu Gln Val 
                165                 170                 175     


Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp Phe Glu 
            180                 185                 190         


Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu Phe Glu 
        195                 200                 205             


Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val Glu Ile 
    210                 215                 220                 


Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu Arg Ala 
225                 230                 235                 240 


Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr Gly Glu 
                245                 250                 255     


Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val Phe Glu 
            260                 265                 270         


Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys Thr Ala 
        275                 280                 285             


Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly Val Leu 
    290                 295                 300                 


His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr Glu Ala 
305                 310                 315                 320 


His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro Ile Thr 
                325                 330                 335     


Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met Gly Pro 
            340                 345                 350         


Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly Glu Lys 
        355                 360                 365             


Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile Gln Asp 
    370                 375                 380                 


Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala Leu Gln 
385                 390                 395                 400 


Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln Ala Gly 
                405                 410                 415     


Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser Ala Lys 
            420                 425                 430         


Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln Asn Glu 
        435                 440                 445             


Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala Val Ile 
    450                 455                 460                 


Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu Lys Glu 
465                 470                 475                 480 


Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp Pro Leu 
                485                 490                 495     


Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro Ser Ala 
            500                 505                 510         


Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His Asn Ala 
        515                 520                 525             


Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val Val Phe 
    530                 535                 540                 


Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr Val Leu 
545                 550                 555                 560 


Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg Ala Leu 
                565                 570                 575     


Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr Ile Glu 
            580                 585                 590         


Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn Trp His 
        595                 600                 605             


Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys Leu Phe 
    610                 615                 620                 


Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala Ser Arg 
625                 630                 635                 640 


Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His Lys Asn 
                645                 650                 655     


Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met Ser Glu 
            660                 665                 670         


Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp Gln Ala 
        675                 680                 685             


Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val Gln Ser 
    690                 695                 700                 


Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg Ser Val 
705                 710                 715                 720 


Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala Ala Lys 
                725                 730                 735     


His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu Glu Arg 
            740                 745                 750         


Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys Glu Leu 
        755                 760                 765             


Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly Asn Ala 
    770                 775                 780                 


Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu Gly Glu 
785                 790                 795                 800 


Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala Ile Glu 
                805                 810                 815     


Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met Glu Leu 
            820                 825                 830         


Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala Gln Gln 
        835                 840                 845             


Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu Ala Leu 
    850                 855                 860                 


Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu Met Gln 
865                 870                 875                 880 


Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile Thr Asp 
                885                 890                 895     


Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu Leu Gly 
            900                 905                 910         


Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys Phe Asn Met Gln Gln 
        915                 920                 925             


Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro Asn Leu Asn Glu Glu 
    930                 935                 940                 


Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp Asp 
945                 950                 955     


