                         SEQUENCE LISTING

<110>  National University of Singapore
 
<120>  CHIMERIC RECEPTOR THAT TRIGGERS ANTIBODY-DEPENDENT CELL 
       CYTOTOXICITY AGAINST MULTIPLE TUMORS

<130>  N0565.70000WO00

<150>  US 62/026,243
<151>  2014-07-18

<150>  US 61/892,218
<151>  2013-10-17

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  2
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
1               5                   10                  15      


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
            20                  25                  30          


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
        35                  40                  45              


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
    50                  55                  60                  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
65                  70                  75                  80  


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
                85                  90                  95      


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
            100                 105                 110         


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
        115                 120                 125             


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
    130                 135                 140                 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
145                 150                 155                 160 


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
                165                 170                 175     


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
            180                 185                 190         


<210>  3
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  4
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
cttctgcagg gggcttgttg ggagtaaaaa tgtgtc                                 36


<210>  8
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
gacacatttt tactcccaac aagccccctg cagaag                                 36


<210>  9
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcatgc ggactgaaga tctcccaaag gctgtggtgt tcctggagcc tcaatggtac      120

agggtgctcg agaaggacag tgtgactctg aagtgccagg gagcctactc ccctgaggac      180

aattccacac agtggtttca caatgagagc ctcatctcaa gccaggcctc gagctacttc      240

attgacgctg ccacagtcga cgacagtgga gagtacaggt gccagacaaa cctctccacc      300

ctcagtgacc cggtgcagct agaagtccat atcggctggc tgttgctcca ggcccctcgg      360

tgggtgttca aggaggaaga ccctattcac ctgaggtgtc acagctggaa gaacactgct      420

ctgcataagg tcacatattt acagaatggc aaaggcagga agtattttca tcataattct      480

gacttctaca ttccaaaagc cacactcaaa gacagcggct cctacttctg cagggggctt      540

gttgggagta aaaatgtgtc ttcagagact gtgaacatca ccatcactca aggtttggca      600

gtgtcaacca tctcatcatt ctttccacct gggtaccaaa ccacgacgcc agcgccgcga      660

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      720

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      780

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt      840

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      900

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga      960

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1020

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1080

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1140

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1200

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1260

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a              1311


<210>  10
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ggcatgcgga ctgaagatct cccaaaggct gtggtgttcc tggagcctca atggtacagg       60

gtgctcgaga aggacagtgt gactctgaag tgccagggag cctactcccc tgaggacaat      120

tccacacagt ggtttcacaa tgagagcctc atctcaagcc aggcctcgag ctacttcatt      180

gacgctgcca cagtcgacga cagtggagag tacaggtgcc agacaaacct ctccaccctc      240

agtgacccgg tgcagctaga agtccatatc ggctggctgt tgctccaggc ccctcggtgg      300

gtgttcaagg aggaagaccc tattcacctg aggtgtcaca gctggaagaa cactgctctg      360

cataaggtca catatttaca gaatggcaaa ggcaggaagt attttcatca taattctgac      420

ttctacattc caaaagccac actcaaagac agcggctcct acttctgcag ggggcttgtt      480

gggagtaaaa atgtgtcttc agagactgtg aacatcacca tcactcaagg tttggcagtg      540

tcaaccatct catcattctt tccacctggg taccaa                                576


<210>  11
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  12
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  13
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  14
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  15
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  16
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
1               5                   10                  15      


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
            20                  25                  30          


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
        35                  40                  45              


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
    50                  55                  60                  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
65                  70                  75                  80  


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
                85                  90                  95      


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
            100                 105                 110         


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
        115                 120                 125             


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
    130                 135                 140                 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
145                 150                 155                 160 


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
                165                 170                 175     


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
            180                 185                 190         


<210>  17
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcatgc ggactgaaga tctcccaaag gctgtggtgt tcctggagcc tcaatggtac      120

agggtgctcg agaaggacag tgtgactctg aagtgccagg gagcctactc ccctgaggac      180

aattccacac agtggtttca caatgagagc ctcatctcaa gccaggcctc gagctacttc      240

attgacgctg ccacagtcga cgacagtgga gagtacaggt gccagacaaa cctctccacc      300

ctcagtgacc cggtgcagct agaagtccat atcggctggc tgttgctcca ggcccctcgg      360

tgggtgttca aggaggaaga ccctattcac ctgaggtgtc acagctggaa gaacactgct      420

ctgcataagg tcacatattt acagaatggc aaaggcagga agtattttca tcataattct      480

gacttctaca ttccaaaagc cacactcaaa gacagcggct cctacttctg cagggggctt      540

tttgggagta aaaatgtgtc ttcagagact gtgaacatca ccatcactca aggtttggca      600

gtgtcaacca tctcatcatt ctttccacct gggtaccaaa ccacgacgcc agcgccgcga      660

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      720

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      780

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt      840

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      900

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga      960

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1020

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1080

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1140

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1200

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1260

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a              1311


<210>  18
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
ggcatgcgga ctgaagatct cccaaaggct gtggtgttcc tggagcctca atggtacagg       60

gtgctcgaga aggacagtgt gactctgaag tgccagggag cctactcccc tgaggacaat      120

tccacacagt ggtttcacaa tgagagcctc atctcaagcc aggcctcgag ctacttcatt      180

gacgctgcca cagtcgacga cagtggagag tacaggtgcc agacaaacct ctccaccctc      240

agtgacccgg tgcagctaga agtccatatc ggctggctgt tgctccaggc ccctcggtgg      300

gtgttcaagg aggaagaccc tattcacctg aggtgtcaca gctggaagaa cactgctctg      360

cataaggtca catatttaca gaatggcaaa ggcaggaagt attttcatca taattctgac      420

ttctacattc caaaagccac actcaaagac agcggctcct acttctgcag ggggcttttt      480

gggagtaaaa atgtgtcttc agagactgtg aacatcacca tcactcaagg tttggcagtg      540

tcaaccatct catcattctt tccacctggg taccaa                                576


