                               SEQUENCE LISTING

<110> BIOGEN IDEC MA INC.
 
<120> ANTI-S1P4 ANTIBODIES AND USES THEREOF

<130> 13751-0154WO1

<140>
<141>

<150> 61/894,095
<151> 2013-10-22

<150> CN 201310492244.1
<151> 2013-10-18

<160> 65    

<170> PatentIn version 3.5

<210> 1
<211> 384
<212> PRT
<213> Homo sapiens

<400> 1
Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe Arg Ser Arg Glu Val Cys Arg Ala Val Leu Ser 
305                 310                 315                 320 


Phe Leu Cys Cys Gly Cys Leu Arg Leu Gly Met Arg Gly Pro Gly Asp 
                325                 330                 335     


Cys Leu Ala Arg Ala Val Glu Ala His Ser Gly Ala Ser Thr Thr Asp 
            340                 345                 350         


Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Gly Ser Arg Ser Leu Ser 
        355                 360                 365             


Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg Ser Ile 
    370                 375                 380                 


<210> 2
<211> 384
<212> PRT
<213> Pan troglodytes

<400> 2
Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe Arg Ser Arg Glu Val Cys Arg Ala Val Leu Ser 
305                 310                 315                 320 


Phe Leu Cys Cys Gly Cys Leu Arg Leu Gly Met Arg Gly Pro Gly Asp 
                325                 330                 335     


Cys Leu Ala Arg Ala Val Glu Ala His Ser Gly Ala Ser Thr Thr Asp 
            340                 345                 350         


Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Gly Ser Arg Ser Leu Ser 
        355                 360                 365             


Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg Ser Ile 
    370                 375                 380                 


<210> 3
<211> 386
<212> PRT
<213> Mus musculus

<400> 3
Met Asn Ile Ser Thr Trp Ser Thr Leu Val Thr Pro Glu Ser Cys His 
1               5                   10                  15      


Arg Leu Ala Ala Ser Gly His Ser Leu Leu Ile Val Leu His Tyr Asn 
            20                  25                  30          


His Ser Gly Arg Leu Ala Ser Arg Gly Gly Ser Glu Asp Gly Gly Gly 
        35                  40                  45              


Leu Gly Met Leu Arg Gly Pro Ser Val Ala Ala Gly Cys Leu Val Val 
    50                  55                  60                  


Leu Glu Asn Ala Met Val Leu Ala Ala Ile Ala Ile Tyr Met Arg Ser 
65                  70                  75                  80  


Arg Arg Trp Val Tyr Tyr Cys Leu Leu Asn Ile Thr Leu Ser Asp Leu 
                85                  90                  95      


Leu Thr Gly Leu Ala Tyr Val Val Asn Val Leu Leu Ser Gly Thr Arg 
            100                 105                 110         


Thr Phe Gln Leu Ser Pro Val His Trp Phe Leu Arg Glu Gly Leu Leu 
        115                 120                 125             


Phe Met Ala Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly 
    130                 135                 140                 


Glu Arg Phe Ala Thr Met Val Arg Val Ala Glu Ser Gly Ala Thr Lys 
145                 150                 155                 160 


Thr Ser Arg Val Tyr Gly Cys Ile Gly Leu Cys Trp Leu Leu Ala Ala 
                165                 170                 175     


Ile Leu Gly Leu Leu Pro Leu Leu Gly Trp Asn Cys Val Cys Ala Phe 
            180                 185                 190         


Pro Arg Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Gly Tyr Val Leu 
        195                 200                 205             


Phe Cys Val Val Val Phe Ala Leu Ile Leu Val Ala Ile Leu Ser Leu 
    210                 215                 220                 


Tyr Gly Ala Ile Phe Arg Val Val Arg Ala Asn Gly Gln Lys Ser Pro 
225                 230                 235                 240 


Arg Pro Pro Ala Arg Arg Lys Ser Arg Arg Leu Leu Asn Thr Val Leu 
                245                 250                 255     


Met Ile Leu Val Ala Phe Val Val Cys Trp Gly Pro Leu Phe Gly Leu 
            260                 265                 270         


Leu Leu Ala Asp Ile Phe Gly Ser Asn Val Trp Ala Gln Glu Tyr Leu 
        275                 280                 285             


Arg Gly Met Asp Trp Ile Leu Ala Leu Ala Val Phe Asn Ser Ala Ile 
    290                 295                 300                 


Asn Pro Leu Ile Tyr Ser Phe Arg Ser Arg Glu Val Gln Arg Ala Val 
305                 310                 315                 320 


Leu Ala Phe Leu Cys Cys Gly Cys Leu Trp Leu Gly Leu Arg Gly Pro 
                325                 330                 335     


Gly Asp Cys Leu Thr Arg Ile Thr Glu Ala His Ser Gly Ala Ser Thr 
            340                 345                 350         


Thr Asp Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Thr Ser Arg Ser 
        355                 360                 365             


Leu Ser Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg 
    370                 375                 380                 


Ser Thr 
385     


<210> 4
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4
Arg Leu Ile Val Leu His Tyr Asn His Ser Gly Arg Leu Ala Gly Arg 
1               5                   10                  15      


Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala Leu Arg 
            20                  25              


<210> 5
<211> 29
<212> PRT
<213> Mus musculus

<400> 5
Leu Leu Ile Val Leu His Tyr Asn His Ser Gly Arg Leu Ala Ser Arg 
1               5                   10                  15      


Gly Gly Ser Glu Asp Gly Gly Gly Leu Gly Met Leu Arg 
            20                  25                  


<210> 6
<211> 351
<212> DNA
<213> Homo sapiens

<400> 6
caggtcaact taagggagtc tgggggaggc ttggtgcggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactgttagc ggttatgcca tgagctgggt ccgccaggct      120

ccagggaggg gctggagtgg gtctcagcta ttagtcgctt ctcggacacg acatactccg      180

cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac acggtgtatc      240

tgcaaatgaa cagctggagc cgaggactcg gccgtatatt actgtgcaag agatccctct      300

gggcacggca tggacgtctg gggccaaggc accctggtca ccgtctcggc c               351


<210> 7
<211> 118
<212> PRT
<213> Homo sapiens

<400> 7
Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Arg Phe Ser Asp Thr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Gly His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210> 8
<211> 321
<212> DNA
<213> Homo sapiens

<400> 8
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaaaatac tatggaagct ggtaccagca gaagccagga      120

caggccctgt ccttgtcatc tatgaagata gtcgaagacc ctctggggtc cctgatcggt      180

tctctggctc catcgacagc tcctccaact ctgcctccct caccatctct ggactgaaga      240

ctgacgacga ggctacacta ctgtcagtct tatgatagca gcaacgtggt attcggcgga      300

gggacccagc tcaccgtttt a                                                321


<210> 9
<211> 108
<212> PRT
<213> Homo sapiens

<400> 9
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Lys Tyr Tyr Gly 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys 
65                  70                  75                  80  


Thr Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ggattcactg ttagcggtta t                                                 21


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Phe Thr Val Ser Gly Tyr 
1               5           


<210> 12
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
agtcgcttct cggacacg                                                     18


<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Ser Arg Phe Ser Asp Thr 
1               5       


<210> 14
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
gatccctctg ggcacggcat ggacgtc                                           27


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Asp Pro Ser Gly His Gly Met Asp Val 
1               5                   


<210> 16
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
caaggagaca gcctcagaaa atactatgga agc                                    33


<210> 17
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Gln Gly Asp Ser Leu Arg Lys Tyr Tyr Gly Ser 
1               5                   10      


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
gaagatagtc gaagaccctc t                                                 21


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Glu Asp Ser Arg Arg Pro Ser 
1               5           


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
cagtcttatg atagcagcaa cgtggta                                           27


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gln Ser Tyr Asp Ser Ser Asn Val Val 
1               5                   


<210> 22
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
caggtcaact taagggagtc tgggggaggc ttggtgcggc ctggggggtc cctgagactc       60

tcctgtgcag cctct                                                        75


<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 24
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
gccatgagct gggtccgcca ggctccaggg aggggctgga gtgggtctca gctatt           56


<210> 25
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Ala Ile 
            


<210> 26
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
acatactccg cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac       60

acggtgtatc tgcaaatgaa cagctgagag ccgaggactc ggccgtatat tactgtgcaa      120

ga                                                                     122


<210> 27
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Thr Tyr Ser Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
tggggccaag gcaccctggt caccgtctcg gcc                                    33


<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210> 30
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgc                                                                  66


<210> 31
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys 
            20          


<210> 32
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
tggtaccagc agaagccagg acaggccctg tccttgtcat ctat                        44


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210> 34
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
ggggtccctg atcggttctc tggctccatc gacagctcct ccaactctgc ctccctcacc       60

atctctggac tgaagactga cgacgaggct actactactg t                          101


<210> 35
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser 
1               5                   10                  15      


Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Asp Asp Glu Ala Asp Tyr 
            20                  25                  30          


Tyr Cys 
        


<210> 36
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
ttcggcggag ggacccagct caccgtttta                                        30


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
1               5                   10  


<210> 38
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 38
caggtcaact taagggagtc tgggggaggc ttggtgcggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactgttagc ggttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtcgct tctcggacac gacatactcc      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtgtat      240

ctgcaaatga acagcctgag agccgaggac tcggccgtat attactgtgc aagagatccc      300

tctgggcacg gcatggacgt ctggggccaa ggcaccctgg tcaccgtctc ggccgctagc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt      660

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      900

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aatga                                                      1335


<210> 39
<211> 444
<212> PRT
<213> Homo sapiens

<400> 39
Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Arg Phe Ser Asp Thr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Gly His Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210> 40
<211> 645
<212> DNA
<213> Homo sapiens

<400> 40
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaaaatac tatggaagct ggtaccagca gaagccagga      120

caggcccctg tccttgtcat ctatgaagat agtcgaagac cctctggggt ccctgatcgg      180

ttctctggct ccatcgacag ctcctccaac tctgcctccc tcaccatctc tggactgaag      240

actgacgacg aggctgacta ctactgtcag tcttatgata gcagcaacgt ggtattcggc      300

ggagggaccc agctcaccgt tttaggtcag cccaaggcgg cgccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt catag                      645


<210> 41
<211> 214
<212> PRT
<213> Homo sapiens

<400> 41
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Lys Tyr Tyr Gly 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys 
65                  70                  75                  80  


Thr Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gly Gly Gly Ser 
1               


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Ser Gly Gly Gly 
1               


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gly Gly Gly Gly Ser 
1               5   


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Ser Gly Gly Gly Gly 
1               5   


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Ser Gly Gly Gly Gly Gly 
1               5       


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210> 50
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gly Phe Thr Val Ser Gly Tyr Ala Met Ser 
1               5                   10  


<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Tyr Ala Met Ser 
1               5   


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Ser Gly Tyr Ala Met Ser 
1               5       


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Ala Ile Ser Arg Phe Ser Asp Thr Thr Tyr 
1               5                   10  


<210> 54
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Ala Ile Ser Arg Phe Ser Asp Thr Thr Tyr Ser Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Trp Val Ser Ala Ile Ser Arg Phe Ser Asp Thr Thr Tyr 
1               5                   10              


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Ala Arg Asp Pro Ser Gly His Gly Met Asp 
1               5                   10  


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Lys Tyr Tyr Gly Ser Trp Tyr 
1               5           


<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Leu Val Ile Tyr Glu Asp Ser Arg Arg Pro 
1               5                   10  


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Gln Ser Tyr Asp Ser Ser Asn Val 
1               5               


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 60
gggacagggc cuuacgguu                                                    19


<210> 61
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
ccggguuccu uccacgaaa                                                    19


<210> 62
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 62
ugacaguaca gcugcgaac                                                    19


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 63
ccugaugugu uguaagaac                                                    19


<210> 64
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe 
305                 


<210> 65
<211> 28
<212> PRT
<213> Pan troglodytes

<400> 65
Arg Leu Ile Val Leu His Tyr Asn His Ser Gly Arg Leu Ala Gly Arg 
1               5                   10                  15      


Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala Leu Arg 
            20                  25              


