                         SEQUENCE LISTING

<110>  Chen, Qiang
       Dinh, Thai
       Fransson, Johan
       Kim, Paul
       Rycyzyn, Michael
       Teng, Fang
       Teplyakov, Alexey
 
<120>  CD200 Receptor 1 agonists

<130>  JBI5030WOPCT

<150>  61891566
<151>  2013-10-16

<150>  61989139
<151>  2014-05-06

<160>  159   

<170>  PatentIn version 3.5

<210>  1
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  1

Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu 
1               5                   10                  15      


Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp 
        35                  40                  45              


Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys 
    50                  55                  60                  


Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp Cys 
145                 150                 155                 160 


Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser 
                165                 170                 175     


Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val 
            180                 185                 190         


Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val 
        195                 200                 205             


Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu 
    210                 215                 220                 


Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val 
225                 230                 235                 240 


Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro Val 
                245                 250                 255     


Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn 
            260                 265                 270         


Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala Leu 
        275                 280                 285             


Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
    290                 295                 


<210>  2
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  2

Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala 
1               5                   10                  15      


Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu 
            20                  25                  30          


Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu 
        35                  40                  45              


Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu 
    50                  55                  60                  


Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp 
65                  70                  75                  80  


Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala 
                85                  90                  95      


Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly 
            100                 105                 110         


Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Gly Lys Glu His His 
        115                 120                 125             


Ile Leu Arg Tyr Phe Thr Ser Pro Asp Leu 
    130                 135             


<210>  3
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  3

Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala 
1               5                   10                  15      


Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu 
            20                  25                  30          


Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu 
        35                  40                  45              


Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu 
    50                  55                  60                  


Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp 
65                  70                  75                  80  


Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala 
                85                  90                  95      


Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly 
            100                 105                 110         


Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Gly Lys Glu His His 
        115                 120                 125             


Ile Leu Arg Tyr Phe Thr Ser Pro Asp Leu 
    130                 135             


<210>  4
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  4

Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu 
1               5                   10                  15      


Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp 
        35                  40                  45              


Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys 
    50                  55                  60                  


Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp Cys 
145                 150                 155                 160 


Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser 
                165                 170                 175     


Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val 
            180                 185                 190         


Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val 
        195                 200                 205             


Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu 
    210                 215                 220                 


Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val 
225                 230                 235                 240 


Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro Val 
                245                 250                 255     


Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn 
            260                 265                 270         


Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala Leu 
        275                 280                 285             


Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
    290                 295                 


<210>  5
<211>  300
<212>  PRT
<213>  Macaca fascicularis

<400>  5

Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn His Ser Lys Val Leu 
1               5                   10                  15      


Ala Glu Val Asn Ile Ser Trp Pro Val Gln Met Ala Arg Asn Ala Val 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Glu Phe Arg Asn Leu Ile Val Ile Thr Trp 
        35                  40                  45              


Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Thr Tyr Arg Lys 
    50                  55                  60                  


Asp Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Thr Pro Asp Gln Asn Ser Asp Leu Gln Ile His Pro Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Ala Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Glu Ser Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Ala Gly Asp Cys 
145                 150                 155                 160 


Ala Pro Thr Glu Gln Glu Tyr Trp Gly Asn Gly Thr Val Thr Val Lys 
                165                 170                 175     


Ser Thr Cys His Trp Glu Gly His Asn Val Ser Thr Val Thr Cys His 
            180                 185                 190         


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
        195                 200                 205             


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Met Pro Tyr Val Ile 
    210                 215                 220                 


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
225                 230                 235                 240 


Ile Ser Gly Cys Arg Lys Tyr Asn Leu Asn Lys Thr Glu Ser Thr Ser 
                245                 250                 255     


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
            260                 265                 270         


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Gln Ala 
        275                 280                 285             


Leu Gln Ser Glu Val Gly Thr Asp Leu His Thr Leu 
    290                 295                 300 


<210>  6
<211>  253
<212>  PRT
<213>  Macaca fascicularis

<400>  6

Ser Cys Met Asp Gly Lys Gln Met Thr Gln Asn Tyr Ser Lys Met Ser 
1               5                   10                  15      


Ala Glu Gly Asn Ile Ser Gln Pro Val Leu Met Asp Thr Asn Ala Asn 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Glu Phe Arg Asn Leu Ile Val Ile Val Trp 
        35                  40                  45              


Glu Ile Ile Ile Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys 
    50                  55                  60                  


Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Lys Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Thr Pro Asp Gln Asn Ser Asp Leu Gln Ile His Pro Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Ala Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Gln Ser Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Ala Gly Asp Cys 
145                 150                 155                 160 


Ala Pro Thr Glu His Glu Tyr Trp Gly Asn Gly Thr Val Thr Val Glu 
                165                 170                 175     


Ser Met Cys His Trp Gly Asp His Asn Ala Ser Thr Val Thr Cys His 
            180                 185                 190         


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Lys Leu Asn Ser 
        195                 200                 205             


Gly Leu Arg Thr Ser Gly Ser Pro Ala Leu Asp Leu Leu Ile Ile Leu 
    210                 215                 220                 


Tyr Val Lys Leu Ser Leu Phe Val Val Ile Leu Val Thr Thr Gly Phe 
225                 230                 235                 240 


Val Phe Phe Gln Arg Ile Asn Tyr Val Arg Lys Ser Leu 
                245                 250             


<210>  7
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  7

Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu 
1               5                   10                  15      


Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp 
        35                  40                  45              


Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys 
    50                  55                  60                  


Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp Cys 
145                 150                 155                 160 


Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser 
                165                 170                 175     


Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val 
            180                 185                 190         


Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val 
        195                 200                 205             


Pro Gly Ala Lys Lys Ser Ala Lys Leu 
    210                 215         


<210>  8
<211>  218
<212>  PRT
<213>  Macaca fascicularis

<400>  8

Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn His Ser Lys Val Leu 
1               5                   10                  15      


Ala Glu Val Asn Ile Ser Trp Pro Val Gln Met Ala Arg Asn Ala Val 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Glu Phe Arg Asn Leu Ile Val Ile Thr Trp 
        35                  40                  45              


Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Thr Tyr Arg Lys 
    50                  55                  60                  


Asp Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Thr Pro Asp Gln Asn Ser Asp Leu Gln Ile His Pro Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Ala Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Glu Ser Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Ala Gly Asp Cys 
145                 150                 155                 160 


Ala Pro Thr Glu Gln Glu Tyr Trp Gly Asn Gly Thr Val Thr Val Lys 
                165                 170                 175     


Ser Thr Cys His Trp Glu Gly His Asn Val Ser Thr Val Thr Cys His 
            180                 185                 190         


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
        195                 200                 205             


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu 
    210                 215             


<210>  9
<211>  221
<212>  PRT
<213>  Macaca fascicularis

<400>  9

Ser Cys Met Asp Gly Lys Gln Met Thr Gln Asn Tyr Ser Lys Met Ser 
1               5                   10                  15      


Ala Glu Gly Asn Ile Ser Gln Pro Val Leu Met Asp Thr Asn Ala Asn 
            20                  25                  30          


Leu Cys Cys Pro Pro Ile Glu Phe Arg Asn Leu Ile Val Ile Val Trp 
        35                  40                  45              


Glu Ile Ile Ile Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys 
    50                  55                  60                  


Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Lys Arg Ile Thr 
65                  70                  75                  80  


Trp Val Ser Thr Pro Asp Gln Asn Ser Asp Leu Gln Ile His Pro Val 
                85                  90                  95      


Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Ala Thr Pro Asp 
            100                 105                 110         


Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu 
        115                 120                 125             


Val Thr Leu Phe Gln Ser Arg Asn Arg Thr Ala Val Cys Lys Ala Val 
    130                 135                 140                 


Ala Gly Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Ala Gly Asp Cys 
145                 150                 155                 160 


Ala Pro Thr Glu His Glu Tyr Trp Gly Asn Gly Thr Val Thr Val Glu 
                165                 170                 175     


Ser Met Cys His Trp Gly Asp His Asn Ala Ser Thr Val Thr Cys His 
            180                 185                 190         


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Lys Leu Asn Ser 
        195                 200                 205             


Gly Leu Arg Thr Ser Gly Ser Pro Ala Leu Asp Leu Leu 
    210                 215                 220     


<210>  10
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH81

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL185

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  12
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH102

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Gly Ser Gly Ser Tyr Tyr Glu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL191

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM147, H2RM227 HCDR1

<400>  14

Ser Tyr Ala Met Ser 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM147, H2RM225  HDCR2

<400>  15

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM147, H2RM226, H2RM218, H2RM219, H2RM225, H2RM226, 
       H2RM227, H2RM279, H2RM280, H2RM281, H2RM282     HCDR3

<400>  16

Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  17
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM189, H2RM190 LCDR1

<400>  17

Arg Ala Ser Gln Ser Val Asn Ser Tyr Tyr Leu Ala 
1               5                   10          


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM147 , H2RM226 , H2RM147 , H2RM187 , H2RM189 , 
       H2RM190 , H2RM195 , H2RM204 , H2RM218 , H2RM225 , H2RM226 , 
       H2RM227  LCDR2

<400>  18

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM190, H2RM187, H2RM190 LCDR3

<400>  19

His Gln Tyr Gly Ala Ser Pro Leu Thr 
1               5                   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211, H2RM266 HCDR1

<400>  20

Ser Tyr Gly Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211, H2RM266  HCDR2

<400>  21

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211, H2RM266  HCDR3

<400>  22

Glu Ala Tyr Gly Ser Gly Ser Tyr Tyr Glu Asp Tyr 
1               5                   10          


<210>  23
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211, H2RM266 LCDR1

<400>  23

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211, H2RM266, H2RM267, H2RM268, H2RM269   LCDR2

<400>  24

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211 LCDR3

<400>  25

Gln Gln Tyr Asn Ser Tyr Pro Arg Thr 
1               5                   


<210>  26
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
1               5                   10                  15      


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
            20                  25                  30          


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
        35                  40                  45              


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
    50                  55                  60                  


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
65                  70                  75                  80  


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
                85                  90                  95      


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
            100                 105                 110         


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
        115                 120                 125             


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
    130                 135                 140                 


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
145                 150                 155                 160 


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
                165                 170                 175     


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
            180                 185                 190         


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
        195                 200                 205             


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
    210                 215                 220                 


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
225                 230                 235                 240 


Asn Gln Asp Arg Glu Pro 
                245     


<210>  27
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Lys Gln Met Thr Gln Asn Tyr Ser Thr Ile Phe Ala Glu Gly Asn 
1               5                   10                  15      


Ile Ser Gln Pro Val Leu Met Asp Ile Asn Ala Val Leu Cys Cys Pro 
            20                  25                  30          


Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu 
        35                  40                  45              


Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu 
    50                  55                  60                  


Thr Lys Glu Thr Asn Cys Thr Val Glu Arg Ile Thr Trp Val Ser Arg 
65                  70                  75                  80  


Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Asp Thr Thr His 
                85                  90                  95      


Asp Gly Tyr Tyr Arg Gly Ile Val Val Thr Pro Asp Gly Asn Phe His 
            100                 105                 110         


Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Asn Leu Phe 
        115                 120                 125             


Gln Ser Arg Asn Ile Thr Ala Val Cys Lys Ala Val Thr Gly Lys Pro 
    130                 135                 140                 


Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Ser Ile Leu Ala Thr Lys 
145                 150                 155                 160 


Gln Glu Tyr Trp Gly Asn Gly Thr Val Thr Val Lys Ser Thr Cys Pro 
                165                 170                 175     


Trp Glu Gly His Lys Ser Thr Val Thr Cys His Val Ser His Leu Thr 
            180                 185                 190         


Gly Asn Lys Ser Leu Ser Val Lys Leu Asn Ser Gly Leu Arg Thr Ser 
        195                 200                 205             


Gly Ser Pro Ala Leu Ser Leu Leu Ile Ile Leu Tyr Val Lys Leu Ser 
    210                 215                 220                 


Leu Phe Val Val Ile Leu Val Thr Thr Gly Phe Val Phe Phe Gln Arg 
225                 230                 235                 240 


Ile Asn His Val Arg Lys Val Leu 
                245             


<210>  28
<211>  301
<212>  PRT
<213>  Mus musculus

<400>  28

Thr Asp Lys Asn Gln Thr Thr Gln Asn Asn Ser Ser Ser Pro Leu Thr 
1               5                   10                  15      


Gln Val Asn Thr Thr Val Ser Val Gln Ile Gly Thr Lys Ala Leu Leu 
            20                  25                  30          


Cys Cys Phe Ser Ile Pro Leu Thr Lys Ala Val Leu Ile Thr Trp Ile 
        35                  40                  45              


Ile Lys Leu Arg Gly Leu Pro Ser Cys Thr Ile Ala Tyr Lys Val Asp 
    50                  55                  60                  


Thr Lys Thr Asn Glu Thr Ser Cys Leu Gly Arg Asn Ile Thr Trp Ala 
65                  70                  75                  80  


Ser Thr Pro Asp His Ser Pro Glu Leu Gln Ile Ser Ala Val Thr Leu 
                85                  90                  95      


Gln His Glu Gly Thr Tyr Thr Cys Glu Thr Val Thr Pro Glu Gly Asn 
            100                 105                 110         


Phe Glu Lys Asn Tyr Asp Leu Gln Val Leu Val Pro Pro Glu Val Thr 
        115                 120                 125             


Tyr Phe Pro Glu Lys Asn Arg Ser Ala Val Cys Glu Ala Met Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ser Pro Asp Gly Asp Cys Val Thr 
145                 150                 155                 160 


Thr Ser Glu Ser His Ser Asn Gly Thr Val Thr Val Arg Ser Thr Cys 
                165                 170                 175     


His Trp Glu Gln Asn Asn Val Ser Asp Val Ser Cys Ile Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Gln Ser Leu Ser Ile Glu Leu Ser Arg Gly Gly Asn 
        195                 200                 205             


Gln Ser Leu Arg Pro Tyr Ile Pro Tyr Ile Ile Pro Ser Ile Ile Ile 
    210                 215                 220                 


Leu Ile Ile Ile Gly Cys Ile Cys Leu Leu Lys Ile Ser Gly Phe Arg 
225                 230                 235                 240 


Lys Cys Lys Leu Pro Lys Leu Glu Ala Thr Ser Ala Ile Glu Glu Asp 
                245                 250                 255     


Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Ser Asn Pro Leu Tyr 
            260                 265                 270         


Asp Thr Val Thr Lys Val Glu Ala Phe Pro Val Ser Gln Gly Glu Val 
        275                 280                 285             


Asn Gly Thr Asp Cys Leu Thr Leu Ser Ala Ile Gly Ile 
    290                 295                 300     


<210>  29
<211>  366
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM190 VH H2RH81 cDNA

<400>  29
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggcag cacctattat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gaaactctat      300

tggtatgttc tctcttcttc gaggttggac tattggggcc agggcaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  30
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM190 VL H2RL185 cDNA

<400>  30
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcca gagcgtcaac agctactatc ttgcgtggta tcagcagaaa      120

ccgggccagg cgccgcgcct gctgatttat ggtgcatcct cccgtgcgac cggcattccg      180

gatcgcttta gcggcagcgg ttccggcacc gattttaccc tgaccattag ccgcctggaa      240

ccggaagatt ttgcggtgta ttattgccat caatatggtg caagtccact tacctttggc      300

cagggcacca aggtggagat caag                                             324


<210>  31
<211>  363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM211 VH H2RH102 cDNA

<400>  31
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagaggct      300

tatggttcgg ggagttatta tgaggactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  32
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM211 VL H2RL191 cDNA

<400>  32
gatattcaga tgactcagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctcggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  33
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PH9L1

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  34
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH111

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL222

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asp Ala Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147, H2RM226, H2RM185, H2RM187, H2RM193, H2RM198, H2RM218, 
       H2RM219, H2RM225, H2RM227   LCDR1

<400>  36

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147, H2RM226, H2RM218, H2RM226, H2RM227 LCDR3

<400>  37

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM226, H2RM279 , H2RM280 , H2RM281 , H2RM282 , H2RM286 , 
       H2RM288 , H2RM289 , H2RM291 , H2RM299 , H2RM302 ,  HCDR1

<400>  38

Ser Tyr Gly Met Gln 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM226, H2RM286, H2RM288, H2RM289, H2RM2891, H2RM299 HDCR2

<400>  39

Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 LCDR3

<400>  40

Gln Gln His Asp Ala Tyr Pro Arg Thr 
1               5                   


<210>  41
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH104

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Asn Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH105

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asn Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  43
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH110

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  44
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH112

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  45
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH116

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH117

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH118

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gln Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  48
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH119

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Ala Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Trp Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH123

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Phe Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  50
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  50

Val Ile Val Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH125

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr His Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH126

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Ile Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  53
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH128

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Leu Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  54
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH136

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Tyr Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  55
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RH137

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Phe Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL153

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  57
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL178

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL152

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ala Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  59
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL165

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  60
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL169

<400>  60

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  61
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL150

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly His Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  62
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL176

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  63
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL188

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly His Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  64
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL147

<400>  64

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly His Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  65
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL192

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  66
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL223

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Gly Ile Asp Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Thr Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL224

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Pro Ile Asp Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RL225

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gln Ile Glu Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM218, H2RM219 HCDR1

<400>  69

Asn Tyr Ala Met Ser 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM225 HCDR1

<400>  70

Ser Tyr Gly Met Asn 
1               5   


<210>  71
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM218 HCDR2

<400>  71

Ala Ile Asp Gly Asn Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM219 HCDR2

<400>  72

Ala Ile Ser Gly Asn Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM227 HCDR2

<400>  73

Ala Ile Ser Gly Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM279, H2RM302 HCDR2

<400>  74

Ala Ile Ser Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM280 HCDR2

<400>  75

Ala Ile Thr Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM281 HCDR2

<400>  76

Ala Ile Gln Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM286, H2RM302 HCDR3

<400>  77

Leu Tyr Phe Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  78
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  78

Val Ile Tyr Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM288 HCDR3

<400>  79

Leu Tyr His Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  80
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM289 HCDR3

<400>  80

Leu Tyr Ile Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  81
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM291 HCDR3

<400>  81

Leu Tyr Leu Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  82
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM299 HCDR3

<400>  82

Leu Tyr Tyr Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM267, H2RM268, H2RM269   LCDR3

<400>  83

Gln Gln His Asn Ser Tyr Pro Arg Thr 
1               5                   


<210>  84
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM191, H2RM195 LCDR1

<400>  84

Arg Ala Ser Gln Ser Val Ser Ser Asp Tyr Leu Ala 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM200, H2RM204 LCDR1

<400>  85

Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  86
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  2RM267  LCDR1

<400>  86

Arg Ala Ser Gly Gly Ile Asp Ser Ala Leu Ala 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM268  LCDR1

<400>  87

Arg Ala Ser Glu Pro Ile Asp Ser Ala Leu Ala 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM269  LCDR1

<400>  88

Arg Ala Ser Ser Gln Ile Glu Ser Trp Leu Ala 
1               5                   10      


<210>  89
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM185, H2RM19, H2RM2198 LCDR2

<400>  89

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM191, H2RM193, H2RM200 LCDR2

<400>  90

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  91
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM185, H2RM191, H2RM193  LCDR3

<400>  91

Gln Gln Tyr Gly Ser Ala Pro Leu Thr 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM189, H2RM195 LCDR3

<400>  92

Gln Gln Tyr Gly Asn Ala Pro Leu Thr 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM198 LCDR3

<400>  93

Gln Gln Tyr Gly Asn Ser Pro Leu Thr 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM200 LCDR3

<400>  94

Gln Gln Tyr Gly His Leu Pro Leu Thr 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM204 LCDR3

<400>  95

Gln Gln Tyr Gly His Ser Pro Leu Thr 
1               5                   


<210>  96
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG2 V234A/G237A/P238S/H268A/V309L/A330S/P331S

<400>  96

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  97
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  97

Val Ile Trp Tyr Ala Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  98

Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  99

Val Ile Trp Tyr Phe Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  100

Val Ile Trp Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  101

Val Ile Trp Tyr His Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  102

Val Ile Trp Tyr Ile Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  103

Val Ile Trp Tyr Lys Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  104

Val Ile Trp Tyr Leu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  105

Val Ile Trp Tyr Pro Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  106

Val Ile Trp Tyr Arg Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  107

Val Ile Trp Tyr Ser Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  108

Val Ile Trp Tyr Thr Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  109

Val Ile Trp Tyr Val Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  110

Val Ile Trp Tyr Tyr Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  111

Val Ile Trp Tyr Asp Ala Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  112

Val Ile Trp Tyr Asp Asp Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  113

Val Ile Trp Tyr Asp Glu Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  114

Val Ile Trp Tyr Asp Phe Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  115

Val Ile Trp Tyr Asp His Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  116

Val Ile Trp Tyr Asp Ile Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  117

Val Ile Trp Tyr Asp Lys Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  118

Val Ile Trp Tyr Asp Leu Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  119

Val Ile Trp Tyr Asp Asn Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  120

Val Ile Trp Tyr Asp Gln Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  121

Val Ile Trp Tyr Asp Arg Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  122

Val Ile Trp Tyr Asp Ser Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  123

Val Ile Trp Tyr Asp Thr Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  124

Val Ile Trp Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  125

Val Ile Trp Tyr Asp Tyr Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  126

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  127

Val Ile Ala Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  128

Val Ile Asp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  129

Val Ile Glu Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  130

Val Ile Phe Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  131

Val Ile Gly Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  132

Val Ile His Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  133

Val Ile Ile Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  134

Val Ile Lys Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  135

Val Ile Leu Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  136

Val Ile Asn Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  137

Val Ile Pro Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  138

Val Ile Gln Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  139

Val Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  140

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 HCDR2 variant

<400>  141

Val Ile Thr Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  142
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM282 HCDR2

<400>  142

Ala Ile Asp Ala Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family HCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ala or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Asn or Qln

<400>  143

Xaa Tyr Xaa Met Xaa 
1               5   


<210>  144
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family HCDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser, Asp, Thr or Qln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Asn, Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa i Ser, Tyr or Thr

<400>  144

Ala Ile Xaa Xaa Xaa Gly Gly Xaa Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family HCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Trp, Phe or His

<400>  145

Leu Tyr Xaa Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  146
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family LCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ser, Tyr, Asp or Asn

<400>  146

Arg Ala Ser Gln Ser Val Xaa Ser Xaa Tyr Leu Ala 
1               5                   10          


<210>  147
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family LCDR2 sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser, Thr or Asn

<400>  147

Gly Ala Ser Xaa Ala Thr 
1               5       


<210>  148
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family LCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Qln or His

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Ala, Asn or His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser, Ala or Leu

<400>  148

Xaa Gln Tyr Gly Xaa Xaa Pro Leu Thr 
1               5                   


<210>  149
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211 family LCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Qln, Gly, Glu or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly, Pro or Qln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Trp or Ala

<400>  149

Arg Ala Ser Xaa Xaa Ile Xaa Ser Xaa Leu Ala 
1               5                   10      


<210>  150
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211 family LCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ala or Ser

<400>  150

Gln Gln His Xaa Xaa Tyr Pro Arg Thr 
1               5                   


<210>  151
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM211 family VL consensus seuence


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Qln, Gly, Glu or Ser

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Gly, Pro or Qln

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Ser, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa isTrp or Ala

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa is Asn or Ser

<400>  151

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Xaa Xaa Ile Xaa Ser Xaa 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Xaa Xaa Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  152
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family VH consensus sqeuence


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Ser or Asp

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is Ala or Gly

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Ser, Asn or Qln

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa is Ser, Asp, Thr or Qln

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa is Ser, Asn, Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa is Ser, Tyr or Thr

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is Trp, Phe or His

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Tyr 
            20                  25                  30          


Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Xaa Xaa Xaa Gly Gly Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Tyr Xaa Tyr Val Leu Ser Ser Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  153
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM147 family VL consensus sqeuence


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Ser, Tyr, Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa is Ser, Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Xaa is Qln or His

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa is Ser, Ala, Asn or His

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is Ser, Ala or Leu

<400>  153

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Xaa Ser Xaa 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Xaa Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Xaa Gln Tyr Gly Xaa Xaa Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  154
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H2RM266 family VH genus


<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa is Ala, Glu, Phe, Gly, His, Ile, Lys, Leu, Pro, Arg, Ser, 
       Thr, Val, Tyr or Asp

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa is Gly, Ala, Asp, Glu, Phe, His, Ile, Lys, Leu, Asn, Qln, 
       Arg, Ser, Thr, Val or Tyr

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, 
       Qln, Arg, Ser, Thr, Val or Tyr

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  Xaa can be any naturally occurring amino acid

<400>  154

Ser Glu Gln Ile Asp Asn Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
1               5                   10                  15      


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25                  30          


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ala Val Ile Xaa Tyr Xaa Xaa Ser Asn Lys 
    50                  55                  60                  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
65                  70                  75                  80  


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Tyr Gly Ser Gly Ser Tyr 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  155
<211>  366
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM226 VH H2RH111 cDNA

<400>  155
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc tcctatggca tgcaatgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg attgacggcg ccggcgggtc tacttactac      180

gcggatagcg tgaaaggccg ctttaccatt tcacgagata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gaaactctat      300

tggtatgttc tctcttcttc gaggttggac tattggggcc agggcaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  156
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM226 VL PH9L1 cDNA

<400>  156
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcca gagcgtgagc agcagctatc tggcgtggta tcagcagaaa      120

ccgggccagg cgccgcgcct gctgatttat ggcgcgagca gccgcgcgac cggcattccg      180

gatcgcttta gcggcagcgg cagcggcacc gattttaccc tgaccattag ccgcctggaa      240

ccggaagatt ttgcggtgta ttattgccag cagtatggca gcagcccgct gacctttggc      300

cagggcacca aagtggaaat taaa                                             324


<210>  157
<211>  363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM266 VH H2RH102 cDNA

<400>  157
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagaggct      300

tatggttcgg ggagttatta tgaggactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  158
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H2RM266 VL H2RL222 cDNA

<400>  158
gatattcaga tgactcagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag catgatgctt atcctcgtac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  159
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human IgG4 with S228P/L234A/L235A substitutions (EU numbering)

<400>  159

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


