                               SEQUENCE LISTING

<110> BIOGEN IDEC MA INC.
 
<120> TRANSGENIC ANIMALS FOR IN VIVO IMAGING

<130> B2047-7098WO

<140>
<141>

<150> 61/891,129
<151> 2013-10-15

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 3594
<212> DNA
<213> Homo sapiens

<400> 1
gctgtcagcg ctgagcacag cgcccaggga gagggacaga cagccggctg catgggacag       60

cggaacccag agtgagaggg gaggtggcag gacagacaga cagcaggggc ggacgcagag      120

acagacagcg gggacaggga ggccgacacg gacatcgaca gcccatagat tcctaaccca      180

gggagccccg gcccctctcg ccgcttccca ccccagacgg agcggggaca ggctgccgag      240

catcctccca cccgccctcc ccgtcctgcc tcctcggccc ctgccagctt cccccgcttg      300

agcacgcagg gcgtccgagg acgcgctggg cctccgcacc cgccctcatg gaggccgtgg      360

agaccgggga acggcccacc ttcggagcct gggactacgg ggtctttgcc ctcatgctcc      420

tggtgtccac tggcatcggg ctgtgggtcg ggctggctcg gggcgggcag cgcagcgctg      480

aggacttctt caccgggggc cggcgcctgg cggccctgcc cgtgggcctg tcgctgtctg      540

ccagcttcat gtcggccgtg caggtgctgg gcgtgccgtc ggaggcctat cgctatggcc      600

tcaagttcct ctggatgtgc ctgggccagc ttctgaactc ggtcctcacc gccctgctct      660

tcatgcccgt cttctaccgc ctgggcctca ccagcaccta cgagtacctg gagatgcgct      720

tcagccgcgc agtgcggctc tgcgggactt tgcagtacat tgtagccacg atgctgtaca      780

ccggcatcgt aatctacgca ccggccctca tcctgaacca agtgaccggg ctggacatct      840

gggcgtcgct cctgtccacc ggaattatct gcaccttcta cacggctgtg ggcggcatga      900

aggctgtggt ctggactgat gtgttccagg tcgtggtgat gctaagtggc ttctgggttg      960

tcctggcacg cggtgtcatg cttgtgggcg ggccccgcca ggtgctcacg ctggcccaga     1020

accactcccg gatcaacctc atggacttta accctgaccc gaggagccgc tatacattct     1080

ggacttttgt ggtgggtggc acgttggtgt ggctctccat gtatggcgtg aaccaggcgc     1140

aggtgcagcg ctacgtggct tgccgcacag agaagcaggc caagctggcc ctgctcatca     1200

accaggtcgg cctgttcctg atcgtgtcca gcgctgcctg ctgtggcatc gtcatgtttg     1260

tgttctacac tgactgcgac cctctcctcc tggggcgcat ctctgcccca gaccagtaca     1320

tgcctctgct ggtgctggac atcttcgaag atctgcctgg agtccccggg cttttcctgg     1380

cctgtgctta cagtggcacc ctcagcacag catccaccag catcaatgct atggctgcag     1440

tcactgtaga agacctcatc aaacctcggc tgcggagcct ggcacccagg aaactcgtga     1500

ttatctccaa ggggctctca ctcatctacg gatcggcctg tctcaccgtg gcagccctgt     1560

cctcactgct cggaggaggt gtccttcagg gctccttcac cgtcatggga gtcatcagcg     1620

gccccctgct gggagccttc atcttgggaa tgttcctgcc ggcctgcaac acaccgggcg     1680

tcctcgcggg actaggcgcg ggcttggcgc tgtcgctgtg ggtggccttg ggcgccacgc     1740

tgtacccacc cagcgagcag accatgaggg tcctgccatc gtcggctgcc cgctgcgtgg     1800

ctctctcagt caacgcctct ggcctcctgg acccggctct cctccctgct aacgactcca     1860

gcagggcccc cagctcagga atggacgcca gccgacccgc cttagctgac agcttctatg     1920

ccatctccta tctctattac ggtgccctgg gcacgctgac cactgtgctg tgcggagccc     1980

tcatcagctg cctgacaggc cccaccaagc gcagcaccct ggccccggga ttgttgtggt     2040

gggacctcgc acggcagaca gcatcagtgg cccccaagga agaagtggcc atcctggatg     2100

acaacttggt caagggtcct gaagaactcc ccactggaaa caagaagccc cctggcttcc     2160

tgcccaccaa tgaggatcgt ctgtttttct tggggcagaa ggagctggag ggggctggct     2220

cttggacccc ctgtgttgga catgatggtg gtcgagacca gcaggagaca aacctctgag     2280

gacagggcca gccgcgggac tgacaccctg ggatggaacc tcaggatggg ccaaacccag     2340

acaacgggcc catggccttg ggctctgatt ggctggattg ccttgtatgc aaatgagttc     2400

aggactacaa taccctaccc tatggggagg ccctgcctcc gggaggtcat tttttaaatc     2460

cagccccttg cttcaaccgt ccccagtatt agacgctgca gccctgacgg ctccccccaa     2520

ataaggctgg gtttttctct ctctcttttt tttttttttt tttttttgag acagggtcat     2580

gctctgtcac ccaggctgga gtgcagtggt gtgatctcgg ctcactgcaa cctctgcctc     2640

ccaggctcaa gtgattctcc tgcctcagcc tcttgagtag ctgggattgt aggtgcccac     2700

caccatgccc agccaacttt ttgtattttt agtagagaca gggtttcacc atgttggtca     2760

ggctggtctc gaactcctga cctcaagtga tccacctgcc tcggcctccc aaagtgctgg     2820

gttacaggcg taagctacca tgcccagcct accgtttttc tcaatctata atagaaagcc     2880

accacgccca ggtaattttt gtaattttgt atttttgtag agacggggtt ttgccatgtt     2940

ggccaggctg gtctcaaact cctgatctca ggtgatcctc ctgccttggc ctcccaaagg     3000

gctgggatta caggggtgag ccaccgcgcc ccacctcttt cttattttct tcctgggatt     3060

ggggagggga tgattcagac cccacatggc ctccaacctt ggcccacaca cctgccatgg     3120

ctcccatcat cctgagcatg ctagcgtccc ctcctcacct gacaatggag gctctcgaat     3180

tgggttgtgt ccccccaaaa tttatgtcta cccagaacct cagaacatga gcttacttgg     3240

aaatagggtc tttgcaggtg taactggtta aattaaaaga ggtattactg gaggaggatg     3300

gatgaatcca gtgactggtt cctcatatga agtagagaag agatgcagag aaacacatgg     3360

ggaagatgcc acgtgaagac agaggcagtg gttggatcaa tgcatctacg agtcggagaa     3420

cccaaggatt gccagcaaca accagaaatc aggagggggg catgagatgc attatttctt     3480

agagccttta gagggaacat ggccctactg acaccttgat gtcagacttc tggctgctag     3540

aactgtcaga gaataaattt ctgttgtttg atgccaaaaa aaaaaaaaaa aaaa           3594


<210> 2
<211> 643
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Ala Val Glu Thr Gly Glu Arg Pro Thr Phe Gly Ala Trp Asp 
1               5                   10                  15      


Tyr Gly Val Phe Ala Leu Met Leu Leu Val Ser Thr Gly Ile Gly Leu 
            20                  25                  30          


Trp Val Gly Leu Ala Arg Gly Gly Gln Arg Ser Ala Glu Asp Phe Phe 
        35                  40                  45              


Thr Gly Gly Arg Arg Leu Ala Ala Leu Pro Val Gly Leu Ser Leu Ser 
    50                  55                  60                  


Ala Ser Phe Met Ser Ala Val Gln Val Leu Gly Val Pro Ser Glu Ala 
65                  70                  75                  80  


Tyr Arg Tyr Gly Leu Lys Phe Leu Trp Met Cys Leu Gly Gln Leu Leu 
                85                  90                  95      


Asn Ser Val Leu Thr Ala Leu Leu Phe Met Pro Val Phe Tyr Arg Leu 
            100                 105                 110         


Gly Leu Thr Ser Thr Tyr Glu Tyr Leu Glu Met Arg Phe Ser Arg Ala 
        115                 120                 125             


Val Arg Leu Cys Gly Thr Leu Gln Tyr Ile Val Ala Thr Met Leu Tyr 
    130                 135                 140                 


Thr Gly Ile Val Ile Tyr Ala Pro Ala Leu Ile Leu Asn Gln Val Thr 
145                 150                 155                 160 


Gly Leu Asp Ile Trp Ala Ser Leu Leu Ser Thr Gly Ile Ile Cys Thr 
                165                 170                 175     


Phe Tyr Thr Ala Val Gly Gly Met Lys Ala Val Val Trp Thr Asp Val 
            180                 185                 190         


Phe Gln Val Val Val Met Leu Ser Gly Phe Trp Val Val Leu Ala Arg 
        195                 200                 205             


Gly Val Met Leu Val Gly Gly Pro Arg Gln Val Leu Thr Leu Ala Gln 
    210                 215                 220                 


Asn His Ser Arg Ile Asn Leu Met Asp Phe Asn Pro Asp Pro Arg Ser 
225                 230                 235                 240 


Arg Tyr Thr Phe Trp Thr Phe Val Val Gly Gly Thr Leu Val Trp Leu 
                245                 250                 255     


Ser Met Tyr Gly Val Asn Gln Ala Gln Val Gln Arg Tyr Val Ala Cys 
            260                 265                 270         


Arg Thr Glu Lys Gln Ala Lys Leu Ala Leu Leu Ile Asn Gln Val Gly 
        275                 280                 285             


Leu Phe Leu Ile Val Ser Ser Ala Ala Cys Cys Gly Ile Val Met Phe 
    290                 295                 300                 


Val Phe Tyr Thr Asp Cys Asp Pro Leu Leu Leu Gly Arg Ile Ser Ala 
305                 310                 315                 320 


Pro Asp Gln Tyr Met Pro Leu Leu Val Leu Asp Ile Phe Glu Asp Leu 
                325                 330                 335     


Pro Gly Val Pro Gly Leu Phe Leu Ala Cys Ala Tyr Ser Gly Thr Leu 
            340                 345                 350         


Ser Thr Ala Ser Thr Ser Ile Asn Ala Met Ala Ala Val Thr Val Glu 
        355                 360                 365             


Asp Leu Ile Lys Pro Arg Leu Arg Ser Leu Ala Pro Arg Lys Leu Val 
    370                 375                 380                 


Ile Ile Ser Lys Gly Leu Ser Leu Ile Tyr Gly Ser Ala Cys Leu Thr 
385                 390                 395                 400 


Val Ala Ala Leu Ser Ser Leu Leu Gly Gly Gly Val Leu Gln Gly Ser 
                405                 410                 415     


Phe Thr Val Met Gly Val Ile Ser Gly Pro Leu Leu Gly Ala Phe Ile 
            420                 425                 430         


Leu Gly Met Phe Leu Pro Ala Cys Asn Thr Pro Gly Val Leu Ala Gly 
        435                 440                 445             


Leu Gly Ala Gly Leu Ala Leu Ser Leu Trp Val Ala Leu Gly Ala Thr 
    450                 455                 460                 


Leu Tyr Pro Pro Ser Glu Gln Thr Met Arg Val Leu Pro Ser Ser Ala 
465                 470                 475                 480 


Ala Arg Cys Val Ala Leu Ser Val Asn Ala Ser Gly Leu Leu Asp Pro 
                485                 490                 495     


Ala Leu Leu Pro Ala Asn Asp Ser Ser Arg Ala Pro Ser Ser Gly Met 
            500                 505                 510         


Asp Ala Ser Arg Pro Ala Leu Ala Asp Ser Phe Tyr Ala Ile Ser Tyr 
        515                 520                 525             


Leu Tyr Tyr Gly Ala Leu Gly Thr Leu Thr Thr Val Leu Cys Gly Ala 
    530                 535                 540                 


Leu Ile Ser Cys Leu Thr Gly Pro Thr Lys Arg Ser Thr Leu Ala Pro 
545                 550                 555                 560 


Gly Leu Leu Trp Trp Asp Leu Ala Arg Gln Thr Ala Ser Val Ala Pro 
                565                 570                 575     


Lys Glu Glu Val Ala Ile Leu Asp Asp Asn Leu Val Lys Gly Pro Glu 
            580                 585                 590         


Glu Leu Pro Thr Gly Asn Lys Lys Pro Pro Gly Phe Leu Pro Thr Asn 
        595                 600                 605             


Glu Asp Arg Leu Phe Phe Leu Gly Gln Lys Glu Leu Glu Gly Ala Gly 
    610                 615                 620                 


Ser Trp Thr Pro Cys Val Gly His Asp Gly Gly Arg Asp Gln Gln Glu 
625                 630                 635                 640 


Thr Asn Leu 
            


<210> 3
<211> 2943
<212> DNA
<213> Mus musculus

<400> 3
ggtcgacggc ccagcaggaa ctcgcgctgc gacgacgctc gctctgagag tccccgacgt       60

cctccgcatc ctctccgttc cgagttacct gtctccatgg agggcgcgga ggcaggggcc      120

cgggccacct tcggcccctg ggactacggc gtgttcgcga ccatgctgct ggtgtccacg      180

ggcatcggtc tgtgggtcgg cctggcccgc ggcggccagc gcagcgccga cgacttcttc      240

accgggggcc ggcagctggc ggcagtgcct gtggggctgt cgctggccgc tagcttcatg      300

tcggctgtgc aggtgctcgg ggtccccgcg gaggcagcgc gctacggtct caagtttctg      360

tggatgtgcg tgggccagtt gctcaattcg ctgctcacag ccttgctctt cttgccgatc      420

ttctaccgcc tgggccttac cagcacctac cagtacctag aactgcgctt cagccgagcg      480

gtccggctct gcgggacgct gcagtacttg gtggccacga tgctgtatac tggcatcgtg      540

atctacgcac ctgcgctcat cctgaaccaa gtgaccgggt tggacatctg ggcatcgctc      600

ctgtccacag gaatcatctg caccttgtac acgaccgtgg gtggtatgaa ggccgtggtc      660

tggacagatg tgttccaggt tgtggtaatg ctcgtcggct tctgggtgat cctggctcga      720

ggtgtcatgc tcatgggggg cccctggaac gtgctcagtc tcgctcaaaa ccattcccgg      780

atcaacctga tggactttga ccctgaccct cggagccgct acaccttctg gacatttgta      840

gtaggtggct ccctggtgtg gctctccatg tatggtgtga accaagccca ggtgcagcgt      900

tatgtggcct gtcacacgga gagaaaggcc aagcttgccc tgcttgtcaa ccagcttggc      960

ctcttcctga ttgtggctag tgcagcttgc tgtggaattg tcatgtttgt ctactacaag     1020

gactgcgacc ccctcctcac aggccgcatc gcagcccccg atcagtacat gccattgctc     1080

gtgttggaca tttttgagga tctgcccgga gtccccgggc tcttcctggc ctgtgcctac     1140

agtggcaccc tcagcaccgc gtccaccagt atcaacgcta tggcagctgt aactgtggaa     1200

gacctcatca agcccaggat gcctagcctg gcaccccgga agctggtttt catctctaaa     1260

gggctctcat tcatctatgg ctcaacctgc ctcactgtgg ctgctctgtc ctcgctgctg     1320

ggaggtgggg tcctccaggg ctctttcacc gtgatgggtg tcatcagtgg gcctctcctt     1380

ggcgctttca ccctcgggat gctgctccca gcctgcaaca cgccaggcgt cctctccggg     1440

ctgacagcag gcttagctgt atccctgtgg gtggccgtgg gggccacgct gtacccgcct     1500

ggagagcaga ccatgggggt gctgcccacc tcggctgcgg gatgcaccaa tgcctctgtc     1560

ctcccgagcc cacccggagc tgccaacact tccagaggga tccccagttc tggaatggac     1620

tcgggccgcc cagcctttgc cgacaccttt tatgctgtct cctatctcta ctacggggct     1680

ctgggtactt tgaccactat gctttgtggt gctctcatca gctacctaac tggccccacc     1740

aagcgcagct ccctgggccc cggattactg tggtgggacc tcgctcggca gacagcatct     1800

gtggccccaa aggaggacac caccaccctg gaggacagcc tggttaaggg accggaagac     1860

atccctgctg cgaccaagaa gccccctggc ttcaggccag aagccgagac ccaccccctg     1920

tatctggggc acgatgctga gaccaacctc tgagggcgag gcccgagaaa gccaatcaca     1980

ggcctcgggc cagcagcctc ctctctgaat ggttggacca tcacctgtac agaagcttgg     2040

ctgatagagg ccctgcccgc cctgaagtcc ctgtgtccca cctgtgcccc ccaaaagagg     2100

gttggttctc tatccaccaa ggaaaacatc tggaaccgca gtgaccttgt agattgcagt     2160

aggcaactga gaacactcag cttctccaga ccgtgaggtt ttcccattta acaagcagag     2220

aagctgaggg cggtcacccc aacgctggga aggtagaggc aagagattca ggaggtcaag     2280

atcatccaca gctacaggct gagaccctgc ccacccccaa atatataaaa gtaatctggg     2340

tgagccgcgt ggcttcgcga cagagggctt gcccagcaca cagaagaccc aaggcagagg     2400

gagaaatggg atgtccacag aacacagagc cccaaggatt gtgaagcttc cgcgaagtgc     2460

caagggacag attctcagag ccctcacaag acacggatgg acgagttgcc tcctcaaagg     2520

gactgacggt ttgcagacta tcagagaaca tgttccttct gtgatcagcc acctaggctc     2580

cgctaatgcg ttccagcttc caggagaccc tgcagacccc acctcccatg ctctctgccc     2640

tttacccctg tgctttgtac acactaggca cctgctctac cactgaacct cacacctaca     2700

cctccatttt tattttattt ttgacacagt gtcttaaggt agtctggctg atgtctggct     2760

atcactcagc gctttttttg tatatcaata tttcattctt tttcattgcc aagtggtctt     2820

gtaaagacat accacagtgt gtcatccatt cccagtgggt ggatgggtga atagctgcat     2880

tgttttcagc ttttgtgtac accaataaaa ttgctgtagg tgttcagaaa aaaaaaaaaa     2940

aaa                                                                   2943


<210> 4
<211> 618
<212> PRT
<213> Mus musculus

<400> 4
Met Glu Gly Ala Glu Ala Gly Ala Arg Ala Thr Phe Gly Pro Trp Asp 
1               5                   10                  15      


Tyr Gly Val Phe Ala Thr Met Leu Leu Val Ser Thr Gly Ile Gly Leu 
            20                  25                  30          


Trp Val Gly Leu Ala Arg Gly Gly Gln Arg Ser Ala Asp Asp Phe Phe 
        35                  40                  45              


Thr Gly Gly Arg Gln Leu Ala Ala Val Pro Val Gly Leu Ser Leu Ala 
    50                  55                  60                  


Ala Ser Phe Met Ser Ala Val Gln Val Leu Gly Val Pro Ala Glu Ala 
65                  70                  75                  80  


Ala Arg Tyr Gly Leu Lys Phe Leu Trp Met Cys Val Gly Gln Leu Leu 
                85                  90                  95      


Asn Ser Leu Leu Thr Ala Leu Leu Phe Leu Pro Ile Phe Tyr Arg Leu 
            100                 105                 110         


Gly Leu Thr Ser Thr Tyr Gln Tyr Leu Glu Leu Arg Phe Ser Arg Ala 
        115                 120                 125             


Val Arg Leu Cys Gly Thr Leu Gln Tyr Leu Val Ala Thr Met Leu Tyr 
    130                 135                 140                 


Thr Gly Ile Val Ile Tyr Ala Pro Ala Leu Ile Leu Asn Gln Val Thr 
145                 150                 155                 160 


Gly Leu Asp Ile Trp Ala Ser Leu Leu Ser Thr Gly Ile Ile Cys Thr 
                165                 170                 175     


Leu Tyr Thr Thr Val Gly Gly Met Lys Ala Val Val Trp Thr Asp Val 
            180                 185                 190         


Phe Gln Val Val Val Met Leu Val Gly Phe Trp Val Ile Leu Ala Arg 
        195                 200                 205             


Gly Val Met Leu Met Gly Gly Pro Trp Asn Val Leu Ser Leu Ala Gln 
    210                 215                 220                 


Asn His Ser Arg Ile Asn Leu Met Asp Phe Asp Pro Asp Pro Arg Ser 
225                 230                 235                 240 


Arg Tyr Thr Phe Trp Thr Phe Val Val Gly Gly Ser Leu Val Trp Leu 
                245                 250                 255     


Ser Met Tyr Gly Val Asn Gln Ala Gln Val Gln Arg Tyr Val Ala Cys 
            260                 265                 270         


His Thr Glu Arg Lys Ala Lys Leu Ala Leu Leu Val Asn Gln Leu Gly 
        275                 280                 285             


Leu Phe Leu Ile Val Ala Ser Ala Ala Cys Cys Gly Ile Val Met Phe 
    290                 295                 300                 


Val Tyr Tyr Lys Asp Cys Asp Pro Leu Leu Thr Gly Arg Ile Ala Ala 
305                 310                 315                 320 


Pro Asp Gln Tyr Met Pro Leu Leu Val Leu Asp Ile Phe Glu Asp Leu 
                325                 330                 335     


Pro Gly Val Pro Gly Leu Phe Leu Ala Cys Ala Tyr Ser Gly Thr Leu 
            340                 345                 350         


Ser Thr Ala Ser Thr Ser Ile Asn Ala Met Ala Ala Val Thr Val Glu 
        355                 360                 365             


Asp Leu Ile Lys Pro Arg Met Pro Ser Leu Ala Pro Arg Lys Leu Val 
    370                 375                 380                 


Phe Ile Ser Lys Gly Leu Ser Phe Ile Tyr Gly Ser Thr Cys Leu Thr 
385                 390                 395                 400 


Val Ala Ala Leu Ser Ser Leu Leu Gly Gly Gly Val Leu Gln Gly Ser 
                405                 410                 415     


Phe Thr Val Met Gly Val Ile Ser Gly Pro Leu Leu Gly Ala Phe Thr 
            420                 425                 430         


Leu Gly Met Leu Leu Pro Ala Cys Asn Thr Pro Gly Val Leu Ser Gly 
        435                 440                 445             


Leu Thr Ala Gly Leu Ala Val Ser Leu Trp Val Ala Val Gly Ala Thr 
    450                 455                 460                 


Leu Tyr Pro Pro Gly Glu Gln Thr Met Gly Val Leu Pro Thr Ser Ala 
465                 470                 475                 480 


Ala Gly Cys Thr Asn Ala Ser Val Leu Pro Ser Pro Pro Gly Ala Ala 
                485                 490                 495     


Asn Thr Ser Arg Gly Ile Pro Ser Ser Gly Met Asp Ser Gly Arg Pro 
            500                 505                 510         


Ala Phe Ala Asp Thr Phe Tyr Ala Val Ser Tyr Leu Tyr Tyr Gly Ala 
        515                 520                 525             


Leu Gly Thr Leu Thr Thr Met Leu Cys Gly Ala Leu Ile Ser Tyr Leu 
    530                 535                 540                 


Thr Gly Pro Thr Lys Arg Ser Ser Leu Gly Pro Gly Leu Leu Trp Trp 
545                 550                 555                 560 


Asp Leu Ala Arg Gln Thr Ala Ser Val Ala Pro Lys Glu Asp Thr Thr 
                565                 570                 575     


Thr Leu Glu Asp Ser Leu Val Lys Gly Pro Glu Asp Ile Pro Ala Ala 
            580                 585                 590         


Thr Lys Lys Pro Pro Gly Phe Arg Pro Glu Ala Glu Thr His Pro Leu 
        595                 600                 605             


Tyr Leu Gly His Asp Ala Glu Thr Asn Leu 
    610                 615             


<210> 5
<211> 2862
<212> DNA
<213> Rattus norvegicus

<400> 5
gcggtgactc gcgctgcgac tctcccactg accgagagtc cccgacgtcc tccgcatcct       60

ctcctcaccg agtcacctgt ctccatggag ggtgcggagg ccggggcccg ggccaccttc      120

ggcgcctggg actacggcgt gttcgcgacc atgctgctgg tgtccacggg catcgggcta      180

tgggtcggcc tggcccgcgg tggccaacgc agtgccgacg acttctttac cgggggccgg      240

cagttggcag ccgttcctgt ggggctgtcg ctggccgcca gtttcatgtc ggctgtgcag      300

gtgctcgggg tccccgccga ggcagcgcgc tacgggctca agttcctgtg gatgtgcgcg      360

ggtcagttgc tcaactcgct gctcacagcg tttctcttct tgccgatctt ctaccgcctg      420

ggccttacca gcacctacca gtacctagag ctgcgcttca gccgagcggt ccggctctgc      480

gggacgctgc agtacttggt ggccacgatg ctgtatacag gcatcgtgat ctacgcgcct      540

gcgctcatcc tgaaccaagt gaccgggttg gacatctggg catcgctcct gtccacagga      600

atcatctgca ccttgtacac taccgtgggt ggtatgaagg ccgtggtctg gacagatgtg      660

ttccaggttg tggtaatgct cgttggcttc tgggtgatcc tggcccgagg cgtcattctc      720

ctggggggtc cccggaacat gctcagcctc gctcagaacc attcccggat caacctgatg      780

gactttgacc ctgatcctcg gagccggtac accttctgga ctttcatagt gggtggcaca      840

ctggtgtggc tctccatgta cggtgtgaac caagcccagg tacagcgcta tgtggcctgc      900

cacacagagg gaaaggccaa actggccctg cttgtcaacc agctgggcct cttcctgatt      960

gtggccagtg cagcttgctg tggcattgtc atgttcgtct actacaagga ctgtgacccc     1020

ctcctcacag gccgtatctc agcccccgac cagtacatgc cgctgcttgt gttggacatt     1080

tttgaggatc tgcccggagt ccccgggctc ttcctggcct gtgcctacag tggcaccctc     1140

agcactgcat ccaccagcat caacgccatg gcagctgtga ctgtggaaga cctcatcaag     1200

ccgaggatgc ctggcctggc acctcggaag ttggttttca tctctaaagg gctctcattc     1260

atctacggct ctgcctgcct cactgtggct gctctgtcct cactgctggg aggtggtgtc     1320

ctccagggtt ccttcactgt gatgggtgtc atcagtgggc ctctactagg cgccttcacg     1380

cttgggatgc tgctcccagc ctgcaacacg ccaggcgttc tctccgggtt ggcagcaggc     1440

ttggctgtat ccctgtgggt ggccgtaggg gccacactgt atccccctgg agagcagacc     1500

atgggggtgc tgcccacctc ggctgcaggc tgcaccaacg attcggtcct cctgggccca     1560

cctggagcca ccaacgcttc caacgggatc cccagttctg gaatggacac gggccgccct     1620

gccctcgctg atacctttta cgccatctcc tatctctatt acggggctct gggcacgctg     1680

accaccatgc tttgcggtgc tctcatcagc taccttactg gtcccaccaa gcgcagctcc     1740

ctgggtcccg gattgctgtg gtgggacctt gctcgacaga cagcgtctgt ggccccaaag     1800

gaagacactg ccaccctgga ggagagcctg gtgaagggac cggaagacat ccctgctgtg     1860

accaagaagc cccctggcct caagccaggc gccgagaccc accccctgta tctggggcac     1920

gatgtggaga ccaacctctg agggtggggt ccaagaaggc caatcacagg cctcgggcca     1980

gcagcctcct ctctggatgg ttggacctga gcatatatag aagcttggct gatacatgcc     2040

ctgcccagaa gtccctgtgt cttacccgca ccaaagagag agagagagcg agagagagag     2100

agagagagac agagagagag agagagagag agagacagag agagagagag agagagagag     2160

agagagagag aggagttggt tctccatcca caaaggaaac cgtctggaac cttcatgccc     2220

ttgtagattt cagtaggcag cggagaacac tcagcttctc cagactgagg ttttctcatt     2280

tatcaggcag agaaaccgag ggctgtcacc ccaacaccgg ggaggagaca gtagaagggt     2340

catagataca aagaaaacta aggcagaggg agaaatgaat tgtctacaga gcacagagct     2400

ccaaggattg tgaagctacc ttgaggtgcc aagggacgga ttctcagagc cttcacaaga     2460

cacaaacgga cgagttgcct cctccagttc agatggtttg cagactatca gagaacatgt     2520

ttctcctgtg atcagctacc tagcctctgc caacgtgttc cagcttccag gaggccacac     2580

agaccccacc ccccatgctc tcacccttta cccctgtgct tttcacacac taggcaactg     2640

ctccaccaca ggacctcaca cctagacctc cgtttttgac acagggcctt aaggtagtct     2700

ggctgccatc tgactatctc tcagcacgtt cacgtgtata atatttcatt ctttttcatt     2760

gccaagttgt cttgtaagga gagaccacaa tgtgtcatcc atgcccagct tttgtgtcta     2820

acaaataaaa tcgctgaagg tgttcaaaaa aaaaaaaaaa aa                        2862


<210> 6
<211> 618
<212> PRT
<213> Rattus norvegicus

<400> 6
Met Glu Gly Ala Glu Ala Gly Ala Arg Ala Thr Phe Gly Ala Trp Asp 
1               5                   10                  15      


Tyr Gly Val Phe Ala Thr Met Leu Leu Val Ser Thr Gly Ile Gly Leu 
            20                  25                  30          


Trp Val Gly Leu Ala Arg Gly Gly Gln Arg Ser Ala Asp Asp Phe Phe 
        35                  40                  45              


Thr Gly Gly Arg Gln Leu Ala Ala Val Pro Val Gly Leu Ser Leu Ala 
    50                  55                  60                  


Ala Ser Phe Met Ser Ala Val Gln Val Leu Gly Val Pro Ala Glu Ala 
65                  70                  75                  80  


Ala Arg Tyr Gly Leu Lys Phe Leu Trp Met Cys Ala Gly Gln Leu Leu 
                85                  90                  95      


Asn Ser Leu Leu Thr Ala Phe Leu Phe Leu Pro Ile Phe Tyr Arg Leu 
            100                 105                 110         


Gly Leu Thr Ser Thr Tyr Gln Tyr Leu Glu Leu Arg Phe Ser Arg Ala 
        115                 120                 125             


Val Arg Leu Cys Gly Thr Leu Gln Tyr Leu Val Ala Thr Met Leu Tyr 
    130                 135                 140                 


Thr Gly Ile Val Ile Tyr Ala Pro Ala Leu Ile Leu Asn Gln Val Thr 
145                 150                 155                 160 


Gly Leu Asp Ile Trp Ala Ser Leu Leu Ser Thr Gly Ile Ile Cys Thr 
                165                 170                 175     


Leu Tyr Thr Thr Val Gly Gly Met Lys Ala Val Val Trp Thr Asp Val 
            180                 185                 190         


Phe Gln Val Val Val Met Leu Val Gly Phe Trp Val Ile Leu Ala Arg 
        195                 200                 205             


Gly Val Ile Leu Leu Gly Gly Pro Arg Asn Met Leu Ser Leu Ala Gln 
    210                 215                 220                 


Asn His Ser Arg Ile Asn Leu Met Asp Phe Asp Pro Asp Pro Arg Ser 
225                 230                 235                 240 


Arg Tyr Thr Phe Trp Thr Phe Ile Val Gly Gly Thr Leu Val Trp Leu 
                245                 250                 255     


Ser Met Tyr Gly Val Asn Gln Ala Gln Val Gln Arg Tyr Val Ala Cys 
            260                 265                 270         


His Thr Glu Gly Lys Ala Lys Leu Ala Leu Leu Val Asn Gln Leu Gly 
        275                 280                 285             


Leu Phe Leu Ile Val Ala Ser Ala Ala Cys Cys Gly Ile Val Met Phe 
    290                 295                 300                 


Val Tyr Tyr Lys Asp Cys Asp Pro Leu Leu Thr Gly Arg Ile Ser Ala 
305                 310                 315                 320 


Pro Asp Gln Tyr Met Pro Leu Leu Val Leu Asp Ile Phe Glu Asp Leu 
                325                 330                 335     


Pro Gly Val Pro Gly Leu Phe Leu Ala Cys Ala Tyr Ser Gly Thr Leu 
            340                 345                 350         


Ser Thr Ala Ser Thr Ser Ile Asn Ala Met Ala Ala Val Thr Val Glu 
        355                 360                 365             


Asp Leu Ile Lys Pro Arg Met Pro Gly Leu Ala Pro Arg Lys Leu Val 
    370                 375                 380                 


Phe Ile Ser Lys Gly Leu Ser Phe Ile Tyr Gly Ser Ala Cys Leu Thr 
385                 390                 395                 400 


Val Ala Ala Leu Ser Ser Leu Leu Gly Gly Gly Val Leu Gln Gly Ser 
                405                 410                 415     


Phe Thr Val Met Gly Val Ile Ser Gly Pro Leu Leu Gly Ala Phe Thr 
            420                 425                 430         


Leu Gly Met Leu Leu Pro Ala Cys Asn Thr Pro Gly Val Leu Ser Gly 
        435                 440                 445             


Leu Ala Ala Gly Leu Ala Val Ser Leu Trp Val Ala Val Gly Ala Thr 
    450                 455                 460                 


Leu Tyr Pro Pro Gly Glu Gln Thr Met Gly Val Leu Pro Thr Ser Ala 
465                 470                 475                 480 


Ala Gly Cys Thr Asn Asp Ser Val Leu Leu Gly Pro Pro Gly Ala Thr 
                485                 490                 495     


Asn Ala Ser Asn Gly Ile Pro Ser Ser Gly Met Asp Thr Gly Arg Pro 
            500                 505                 510         


Ala Leu Ala Asp Thr Phe Tyr Ala Ile Ser Tyr Leu Tyr Tyr Gly Ala 
        515                 520                 525             


Leu Gly Thr Leu Thr Thr Met Leu Cys Gly Ala Leu Ile Ser Tyr Leu 
    530                 535                 540                 


Thr Gly Pro Thr Lys Arg Ser Ser Leu Gly Pro Gly Leu Leu Trp Trp 
545                 550                 555                 560 


Asp Leu Ala Arg Gln Thr Ala Ser Val Ala Pro Lys Glu Asp Thr Ala 
                565                 570                 575     


Thr Leu Glu Glu Ser Leu Val Lys Gly Pro Glu Asp Ile Pro Ala Val 
            580                 585                 590         


Thr Lys Lys Pro Pro Gly Leu Lys Pro Gly Ala Glu Thr His Pro Leu 
        595                 600                 605             


Tyr Leu Gly His Asp Val Glu Thr Asn Leu 
    610                 615             


