                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, as represented by the 
       Secretary, Department of Health and Human Services
       Pfister, Thomas D
       Marrero, Allison M
       Parchment, Ralph E
       Doroshow, James H
 
<120>  ANTIBODIES THAT SPECIFICALLY BIND ATAXIA TELANGIECTASIA-MUTATED 
       AND RAD3-RELATED KINASE PHOSPHORYLATED AT POSITION 1989 AND THEIR
        USE

<130>  4239-91933-02

<150>  61/893,070
<151>  2013-10-18

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Phe Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Cys 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Phe Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Cys 
1               5                   10                  15  


<210>  6
<211>  455
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro Gly 
            20                  25                  30          


Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Met Tyr 
        35                  40                  45              


Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe 
    50                  55                  60                  


Ile Gly Met Ile Gly Ser Gly Gly Asn Thr Val Tyr Ala Ser Trp Ala 
65                  70                  75                  80  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Gly Leu Lys 
                85                  90                  95      


Met Thr Ser Leu Thr Gln Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            100                 105                 110         


Glu Gly Ser Gly Gly Ser Met Asp Phe Trp Gly Pro Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
                165                 170                 175     


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
        195                 200                 205             


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn 
        275                 280                 285             


Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe 
    290                 295                 300                 


Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp 
305                 310                 315                 320 


Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu 
            340                 345                 350         


Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser 
        355                 360                 365             


Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Ile Ser Arg Ser Pro Gly Lys 
    450                 455 


<210>  7
<211>  238
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
1               5                   10                  15      


Pro Gly Ala Thr Phe Ala Leu Val Met Thr Gln Ser Pro Ser Ser Val 
            20                  25                  30          


Ser Ala Ala Val Gly Gly Thr Val Thr Ile Thr Cys Gln Ala Ser Gln 
        35                  40                  45              


Ser Leu Tyr Asn Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Arg Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asp Leu Glu Cys Glu Asp Ala Ala Thr Tyr Tyr Cys Leu 
            100                 105                 110         


Gly Glu Tyr Lys Asp Asn Val Asp Asp Gly Asn Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Glu Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val 
145                 150                 155                 160 


Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val 
                165                 170                 175     


Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln 
            180                 185                 190         


Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln 
    210                 215                 220                 


Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235             


<210>  8
<211>  1371
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  8
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc gcccctggga cacccctgac actcacctgt      120

accgtctctg gaatcgacct catgtacaat gcaatgaact gggtccgcca ggctccaggg      180

aagggcctgg aattcatcgg aatgattggt agtggtggta atacagtcta tgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tgggtctgaa gatgaccagt      300

ctgacacagg aggacacggc cacctatttc tgtgccagag agggtagtgg tggcagtatg      360

gacttctggg gcccaggcac cctggtcacc gtctcctcag ggcaacctaa ggctccatca      420

gtcttcccac tggccccctg ctgcggggac acacccagct ccacggtgac cctgggctgc      480

ctggtcaaag ggtacctccc ggagccagtg accgtgacct ggaactcggg caccctcacc      540

aatggggtac gcaccttccc gtccgtccgg cagtcctcag gcctctactc gctgagcagc      600

gtggtgagcg tgacctcaag cagccagccc gtcacctgca acgtggccca cccagccacc      660

aacaccaaag tggacaagac cgttgcgccc tcgacatgca gcaagcccac gtgcccaccc      720

cctgaactcc tggggggacc gtctgtcttc atcttccccc caaaacccaa ggacaccctc      780

atgatctcac gcacccccga ggtcacatgc gtggtggtgg acgtgagcca ggatgacccc      840

gaggtgcagt tcacatggta cataaacaac gagcaggtgc gcaccgcccg gccgccgcta      900

cgggagcagc agttcaacag cacgatccgc gtggtcagca ccctccccat cgcgcaccag      960

gactggctga ggggcaagga gttcaagtgc aaagtccaca acaaggcact cccggccccc     1020

atcgagaaaa ccatctccaa agccagaggg cagcccctgg agccgaaggt ctacaccatg     1080

ggccctcccc gggaggagct gagcagcagg tcggtcagcc tgacctgcat gatcaacggc     1140

ttctaccctt ccgacatctc ggtggagtgg gagaagaacg ggaaggcaga ggacaactac     1200

aagaccacgc cggccgtgct ggacagcgac ggctcctact tcctctacag caagctctca     1260

gtgcccacga gtgagtggca gcggggcgac gtcttcacct gctccgtgat gcacgaggcc     1320

ttgcacaacc actacacgca gaagtccatc tcccgctctc cgggtaaatg a              1371


<210>  9
<211>  720
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  9
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc tggtgatgac ccagtctcca tcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca cttgccaggc cagtcagagt ctttataata acaactactt agcctggttt      180

cagcagaaac cagggcagcg tcccaagctc ctgatctaca aggcatccac tctggcaagt      240

ggggtcccat cgcgcttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gacctggagt gtgaagatgc tgccacttac tactgcctag gcgaatataa ggataatgta      360

gatgatggta atgctttcgg cggagggacc gaggtggtgg tcgaaggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


