                         SEQUENCE LISTING

<110>  Stichting voor de Technische Wetenschappen
 
<120>  Novel polypeptide and uses thereof.

<130>  58802PC

<150>  NL2011626
<151>  2013-10-17

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  2
<211>  358
<212>  PRT
<213>  Sus scrofa

<400>  2

Ala Glu Met Lys Thr Tyr Ser Gln Arg Ala Val Ala Asn Ala Cys Ala 
1               5                   10                  15      


Leu Val Met Cys Ser Pro Met Glu Asn Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Val Gly Arg Ala Gly Met Pro Gly Leu Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Thr Gly Glu Pro Gly Ala Lys Gly 
65                  70                  75                  80  


Asp Ile Gly Pro Cys Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
                85                  90                  95      


Ala Gly Lys Glu Gly Pro Ser Gly Gln Gln Gly Asn Ile Gly Pro Pro 
            100                 105                 110         


Gly Thr Pro Gly Pro Lys Gly Glu Thr Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Leu Gly Met Gln Gly Ser Thr Gly Ala Arg Gly Pro Ala Gly Leu 
    130                 135                 140                 


Lys Gly Glu Arg Gly Ala Pro Gly Glu Arg Gly Ala Pro Gly Ser Ala 
145                 150                 155                 160 


Gly Ala Ala Gly Pro Ala Gly Ala Thr Gly Pro Gln Gly Pro Ser Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Arg Gly Pro Pro Gly Glu 
            180                 185                 190         


Arg Gly Ala Lys Gly Glu Ser Gly Leu Pro Gly Ile Thr Ala Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Thr Leu Gln Gly Gln Val Gln Arg Leu Gln Lys Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Arg Gly Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Gly Gly Phe Glu Lys Thr Phe Gln Asp 
                245                 250                 255     


Ala Gln Gln Val Cys Thr Gln Ala Gly Gly Gln Met Ala Ser Pro Arg 
            260                 265                 270         


Ser Glu Thr Glu Asn Glu Ala Leu Ser Gln Leu Val Thr Ala Gln Asn 
        275                 280                 285             


Lys Ala Ala Phe Leu Ser Met Thr Asp Ile Lys Thr Glu Gly Asn Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Pro Leu Val Tyr Ala Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asn Asn Gly Gly Ser Ser Gly Ala Glu Asn Cys Val Glu 
                325                 330                 335     


Ile Phe Pro Asn Gly Lys Trp Asn Asp Lys Ala Cys Gly Glu Leu Arg 
            340                 345                 350         


Leu Val Ile Cys Glu Phe 
        355             


<210>  3
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c) + V251E+K287Q+E289K+D324N+D330N


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  3

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Glu Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Gln Asn 
        275                 280                 285             


Lys Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asn Asp Xaa Gly Ser Glu Asn Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  4
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+V251E+K287Q+E289K+D324N


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  4

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Glu Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Gln Asn 
        275                 280                 285             


Lys Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asn Asp Xaa Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  5
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+V251E+K287Q+E289K


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  5

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Glu Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Gln Asn 
        275                 280                 285             


Lys Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Xaa Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  6
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+D330N+D324N


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  6

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asn Asp Xaa Gly Ser Glu Asn Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  7
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+D330N


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  7

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Xaa Gly Ser Glu Asn Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  8
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGSS(326-326a-326b-326c)

<400>  8

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Xaa Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  9
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V251E+K287Q+E289K

<400>  9

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Glu Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Gln Asn 
        275                 280                 285             


Lys Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  10
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V251E

<400>  10

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Glu Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  11
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGS(326a-326b-326c)


<220>
<221>  MISC_FEATURE
<222>  (326)..(326)
<223>  GGGS(326-326a-326b-326c)

<400>  11

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Xaa Gly Ser Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  12
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SGA(328a-328b-328c)


<220>
<221>  MISC_FEATURE
<222>  (328)..(328)
<223>  SSGA(328-328a-328b-328c)

<400>  12

Ala Glu Met Lys Thr Tyr Ser His Arg Thr Thr Pro Ser Ala Cys Thr 
1               5                   10                  15      


Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro Gly Arg Asp Gly 
            20                  25                  30          


Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly Asp Pro Gly Leu 
        35                  40                  45              


Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln Ala Gly Pro Val 
    50                  55                  60                  


Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro Gly Pro Lys Gly 
65                  70                  75                  80  


Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro 
                85                  90                  95      


Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn Ile Gly Pro Gln 
            100                 105                 110         


Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys Gly Glu Val Gly 
        115                 120                 125             


Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly Leu Ala Gly Pro 
    130                 135                 140                 


Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val Pro Gly Asn Thr 
145                 150                 155                 160 


Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln Gly Ser Pro Gly 
                165                 170                 175     


Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly Ile Pro Gly Asp 
            180                 185                 190         


Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val Ala Ser Leu Arg 
        195                 200                 205             


Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala 
    210                 215                 220                 


Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val 
225                 230                 235                 240 


Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu 
                245                 250                 255     


Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg 
            260                 265                 270         


Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn 
        275                 280                 285             


Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe 
    290                 295                 300                 


Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly 
305                 310                 315                 320 


Glu Pro Asn Asp Asp Gly Gly Xaa Glu Asp Cys Val Glu Ile Phe Thr 
                325                 330                 335     


Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val 
            340                 345                 350         


Cys Glu Phe 
        355 


<210>  13
<211>  1726
<212>  DNA
<213>  Homo sapiens

<400>  13
cggaattagg gagatagttg gtattaggat taggattgtt gtgaagtata gtacggatgc       60

tacttgtgca atgatggtaa aagggtagct tactggttgt cctccgattc aggttagaat      120

gaggaggtct gcggcttgga gctcctgggg cctaacaaaa agaaacctgc catgctgctc      180

ttcctcctct ctgcactggt cctactcaca cagcccctgg gctacctgga agcagaaatg      240

aagacctact cccacagaac aatgcccagt gcttgcaccc tggtcatgtg tagctcagtg      300

gagagtggcc tgcctggtcg cgatggacgg gatgggagag agggccctcg gggcgagaag      360

ggggacccag gtttgccagg agctgcaggg caagcaggga tgcctggaca agctggccca      420

gttgggccca aaggggacaa tggctctgtt ggagaacctg gaccaaaggg agacactggg      480

ccaagtggac ctccaggacc tcccggtgtg cctggtccag ctggaagaga aggtcccctg      540

gggaagcagg ggaacatagg acctcagggc aagccaggcc caaaaggaga agctgggccc      600

aaaggagaag taggtgcccc aggcatgcag ggctcggcag gggcaagagg cctcgcaggc      660

cctaagggag agcgaggtgt ccctggtgag cgtggagtcc ctggaaacac aggggcagca      720

gggtctgctg gagccatggg tccccaggga agtccaggtg ccaggggacc cccgggattg      780

aagggggaca aaggcattcc tggagacaaa ggagcaaagg gagaaagtgg gcttccagat      840

gttgcttctc tgaggcagca ggttgaggcc ttacagggac aagtacagca cctccaggct      900

gctttctctc agtataagaa agttgagctc ttcccaaatg gccaaagtgt cggggagaag      960

attttcaaga cagcaggctt tgtaaaacca tttacggagg cacagctgct gtgcacacag     1020

gctggtggac agttggcctc tccacgctct gccgctgaga atgccgcctt gcaacagctg     1080

gtcgtagcta agaacgaggc tgctttcctg agcatgactg attccaagac agagggcaag     1140

ttcacctacc ccacaggaga gtccctggtc tattccaact gggccccagg ggagcccaac     1200

gatgatggcg ggtcagagga ctgtgtggag atcttcacca atggcaagtg gaatgacagg     1260

gcttgtggag aaaagcgtct tgtggtctgc gagttctgag ccaactgggg tgggtggggc     1320

agtgcttggc ccaggagttt ggccagaagt caaggcttag accctcatgc tgccaatatc     1380

ctaataaaaa ggtgaccatc aaaaaaaaaa gctgagaatg ccgccttgca acagctggtc     1440

gtagctaaga acgaggctgc tttcctgagc atgactgatt ccaagacaga gggcaagttc     1500

acctacccca caggagagtc cctggtctat tccaactggg ccccagggga gcccaacgat     1560

gatggcgggt cagaggactg tgtggagatc ttcaccaatg gcaagtggaa tgacagggct     1620

tgtggagaaa agcgtcttgt ggtctgcgag ttctgagcca actggggtgg gtggggcagt     1680

gcttggccca ggagtttggc cagaagtcaa ggcttagacc ctcatg                    1726


<210>  14
<211>  1385
<212>  DNA
<213>  Sus scrofa

<400>  14
cgagtttgcc tggagattct gagctctaga ggacgcaact gacatgcttc tcctccctct       60

ctccgtgctg atcctgctca cacagccccc gaggtcactg ggagcagaaa tgaagaccta      120

ttcccagaga gcagtggcca acgcctgcgc cctggtcatg tgtagcccca tggagaatgg      180

cctgcctggt cgtgatggtc gggatgggag agagggccct cggggcgaga agggggatcc      240

aggtttgcca ggagctgtag ggcgagcggg gatgcctgga ctggctggcc cagttgggcc      300

caaaggggac aacggctcta ctggagaacc cggagcaaag ggagacattg gaccatgcgg      360

gcctccagga cctccaggta tacctggtcc agccggaaaa gaaggtccct cagggcagca      420

ggggaacata ggacctccag gcacaccagg ccccaaagga gagactgggc ccaaaggaga      480

agtgggtgcc ctgggcatgc agggctctac aggggcaaga ggccctgcag gtcttaaagg      540

agagagaggt gcccccggtg agcgtggagc ccctggaagt gctggggcag cagggcctgc      600

tggagccacg ggccctcagg gcccttcagg tgccaggggc cccccaggac tgaaagggga      660

cagaggtcct cctggagaaa gaggagccaa gggagagagt ggactcccag gcatcactgc      720

tctgaggcaa caggtggaga ccttacaggg gcaggtacaa cgcctccaga aggccttctc      780

tcagtataag aaagtggagc tcttccccaa tggccgaggt gtcggggaga agatcttcaa      840

gacgggaggc tttgaaaaga cttttcagga tgctcagcag gtatgcacac aggccggggg      900

acagatggcc tccccacgct ctgagactga gaacgaggcc ttgagccagc tggtcacagc      960

tcagaataag gctgctttcc tgagcatgac tgacatcaag acggagggca atttcaccta     1020

ccccacgggg gagcccctgg tctatgccaa ctgggcccct ggggagccca acaacaatgg     1080

tggcagcagc ggagcagaga actgtgtgga gatctttccc aatggcaagt ggaatgacaa     1140

ggcctgcgga gaactgcgcc tcgtgatctg cgagttctga gcccctgggg agggaggggc     1200

ggtgtccaga gctgtgtgct accaacgtcc caataaatag gtgaccttct gctggccagg     1260

gcttctccac agagccgtgg gacgaggcca gaaggtaggg agcctatgga acgcctccct     1320

cagaataaag tacgaaactg gcctcacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaa                                                                 1385


<210>  15
<211>  1225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+V251E+K287Q+E289K+D324N+D330N

<400>  15
aacaaaaaga aacctgccat gctgctcttc ctcctctctg cactggtcct actcacacag       60

cccctgggct acctggaagc agaaatgaag acctactccc acagaacaat gcccagtgct      120

tgcaccctgg tcatgtgtag ctcagtggag agtggcctgc ctggtcgcga tggacgggat      180

gggagagagg gccctcgggg cgagaagggg gacccaggtt tgccaggagc tgcagggcaa      240

gcagggatgc ctggacaagc tggcccagtt gggcccaaag gggacaatgg ctctgttgga      300

gaacctggac caaagggaga cactgggcca agtggacctc caggacctcc cggtgtgcct      360

ggtccagctg gaagagaagg tcccctgggg aagcagggga acataggacc tcagggcaag      420

ccaggcccaa aaggagaagc tgggcccaaa ggagaagtag gtgccccagg catgcagggc      480

tcggcagggg caagaggcct cgcaggccct aagggagagc gaggtgtccc tggtgagcgt      540

ggagtccctg gaaacacagg ggcagcaggg tctgctggag ccatgggtcc ccagggaagt      600

ccaggtgcca ggggaccccc gggattgaag ggggacaaag gcattcctgg agacaaagga      660

gcaaagggag aaagtgggct tccagatgtt gcttctctga ggcagcaggt tgaggcctta      720

cagggacaag tacagcacct ccaggctgct ttctctcagt ataagaaagt tgagctcttc      780

ccaaatggcc aaagtgtcgg ggagaagatt ttcaagacag caggctttga aaaaccattt      840

acggaggcac agctgctgtg cacacaggct ggtggacagt tggcctctcc acgctctgcc      900

gctgagaatg ccgccttgca acagctggtc gtagctcaga acaaggctgc tttcctgagc      960

atgactgatt ccaagacaga gggcaagttc acctacccca caggagagtc cctggtctat     1020

tccaactggg ccccagggga gcccaacaat gatggcggca gcagcgggtc agagaactgt     1080

gtggagatct tcaccaatgg caagtggaat gacagggctt gtggagaaaa gcgtcttgtg     1140

gtctgcgagt tctgagccaa ctggggtggg tggggcagtg cttggcccag gagtttggcc     1200

agaagtcaag gcttagaccc tcatg                                           1225


<210>  16
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+V251E+K287Q+E289K+D324N

<400>  16
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gaaaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgca gaacaaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaaca acgatggcgg cagcagcggc agcgaagatt gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  17
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+V251E+K287Q+E289K

<400>  17
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gaaaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgca gaacaaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcagcggc agcgaagatt gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  18
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+D330N+D324N

<400>  18
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gtgaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaaca acgatggcgg cagcagcggc agcgaaaact gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  19
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)+D330N

<400>  19
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gtgaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcagcggc agcgaaaact gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  20
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSS(326a-326b-326c)

<400>  20
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gtgaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcagcggc agcgaagatt gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  21
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V251E+K287Q+E289K

<400>  21
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gaaaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgca gaacaaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcgaagat tgcgtggaaa tttttaccaa cggcaaatgg     1020

aacgatcgcg cgtgcggcga aaaacgcctg gtggtgtgcg aattt                     1065


<210>  22
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V251E

<400>  22
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gaaaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcgaagat tgcgtggaaa tttttaccaa cggcaaatgg     1020

aacgatcgcg cgtgcggcga aaaacgcctg gtggtgtgcg aattt                     1065


<210>  23
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GGS (326a-326b-326c)

<400>  23
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gtgaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cggcagcggc agcgaagatt gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  24
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SGA(328a-328b-328c)

<400>  24
gcggaaatga aaacctatag ccatcgcacc accccgagcg cgtgcaccct ggtgatgtgc       60

agcagcgtgg aaagcggcct gccgggccgc gatggccgcg atggccgcga aggcccgcgc      120

ggcgaaaaag gcgatccggg cctgccgggc gcggcgggcc aggcgggcat gccgggccag      180

gcgggcccgg tgggcccgaa aggcgataac ggcagcgtgg gcgaaccggg cccgaaaggc      240

gataccggcc cgagcggccc gccgggcccg ccgggcgtgc cgggcccggc gggccgcgaa      300

ggcccgctgg gcaaacaggg caacattggc ccgcagggca aaccgggccc gaaaggcgaa      360

gcgggcccga aaggcgaagt gggcgcgccg ggcatgcagg gcagcgcggg cgcgcgcggc      420

ctggcgggcc cgaaaggcga acgcggcgtg ccgggcgaac gcggcgtgcc gggcaacacc      480

ggcgcggcgg gcagcgcggg cgcgatgggc ccgcagggca gcccgggcgc gcgcggcccg      540

ccgggcctga aaggcgataa aggcattccg ggcgataaag gcgcgaaagg cgaaagcggc      600

ctgccggatg tggcgagcct gcgccagcag gtggaagcgc tgcagggcca ggtgcagcat      660

ctgcaggcgg cgtttagcca gtataaaaaa gtggaactgt ttccgaacgg ccagagcgtg      720

ggcgaaaaaa tttttaaaac cgcgggcttt gtgaaaccgt ttaccgaagc gcagctgctg      780

tgcacccagg cgggcggcca gctggcgagc ccgcgcagcg cggcggaaaa cgcggcgctg      840

cagcagctgg tggtggcgaa aaacgaagcg gcgtttctga gcatgaccga tagcaaaacc      900

gaaggcaaat ttacctatcc gaccggcgaa agcctggtgt atagcaactg ggcgccgggc      960

gaaccgaacg atgatggcgg cagcagcggc gcggaagatt gcgtggaaat ttttaccaac     1020

ggcaaatgga acgatcgcgc gtgcggcgaa aaacgcctgg tggtgtgcga attt           1074


<210>  25
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSP-D_FOR

<400>  25
gcgtctcgga tccgcctgga gattctgagc tctag                                  35


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSP-D_REV

<400>  26
gcggccgctg agggaggcgt tccataggc                                         29


<210>  27
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis V251E_FOR

<400>  27
gattttcaag acagcaggct ttgaaaaacc atttacggag gcacag                      46


<210>  28
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis V251E_REV

<400>  28
ctgtgcctcc gtaaatggtt tttcaaagcc tgctgtcttg aaaatc                      46


<210>  29
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis K287Q & E289K_FOR

<400>  29
gcaacagctg gtcgtagctc agaacaaggc tgctttcctg agcatg                      46


<210>  30
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis K287Q & E289K_REV

<400>  30
catgctcagg aaagcagcct tgttctgagc tacgaccagc tgttgc                      46


<210>  31
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis D324N_FOR

<400>  31
caggggagcc caacaatgat ggcggcagca gcgggtcaga ggac                        44


<210>  32
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis D324N_REV

<400>  32
gtcctctgac ccgctgctgc cgccatcatt gttgggctcc cctg                        44


<210>  33
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis GSS(326a-326b-326c)_FOR

<400>  33
gagcccaacg atgatggcgg cagcagcggg tcagaggact gtgtggag                    48


<210>  34
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis GSS(326a-326b-326)_REV

<400>  34
ctccacacag tcctctgacc cgctgctgcc gccatcatcg ttgggctc                    48


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis D330N_FOR

<400>  35
ggcggcagca gcgggtcaga gaactgtgtg gagatcttca cc                          42


<210>  36
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis D330N_REV

<400>  36
ggtgaagatc tccacacagt tctctgaccc gctgctgccg cc                          42


<210>  37
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis SGA (328a-328b-328c)_FOR

<400>  37
gcccaacgat gatggcgggt caagcggagc agaggactgt gtggagatc                   49


<210>  38
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis SGA (328a-328b-328c)_REV

<400>  38
gatctccaca cagtcctctg ctccgcttga cccgccatca tcgttgggc                   49


<210>  39
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis GGS(326a-326b-326c)_FOR

<400>  39
gagcccaacg atgatggcgg cggcagcggg tcagaggact gtgtggag                    48


<210>  40
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  site directed mutagenesis GGS(326a-326b-326c)_REV

<400>  40
ctccacacag tcctctgacc cgctgccgcc gccatcatcg ttgggctc                    48


