                         SEQUENCE LISTING

<110>  GeneFrontier Corporation
       KEIO UNIVERSITY
 
<120>  HUMAN ANTIBODY AGAINST AGGRECANASE-TYPE ADAMTS SPECIES FOR 
       THERAPEUTICS OF AGGRECANASE-RELATED DISEASES

<130>  092251

<150>  US 61/891,087
<151>  2013-10-15

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 LCDR1

<400>  1

Arg Ser Ser Gln Ser Ile Leu Tyr Ser Ser Asn Asn Asn Tyr Leu Ala 
1               5                   10                  15      


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 LCDR2

<400>  2

His Thr Ala Ser Ala Arg Glu Ser 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 LCDR3

<400>  3

Gln Gln Tyr Tyr Ser Val Ser Ile 
1               5               


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 HCDR1

<400>  4

Gly Thr Phe Ser Ser Phe Ala Ile Ser 
1               5                   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 HCDR2

<400>  5

Gly Ile Phe Pro Ile Phe Gly Gln Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 HCDR3

<400>  6

Phe Ser Asp Trp Trp Glu Trp Gln Met Asp Tyr 
1               5                   10      


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 VL(kappa4)

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile His Thr Ala Ser Ala Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Val Ser Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 VH(VH1a)

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Phe Pro Ile Phe Gly Gln Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ser Asp Trp Trp Glu Trp Gln Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 epitope

<400>  9

Tyr Cys Glu Gly Arg Arg Thr Arg Phe 
1               5                   


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 epitope

<400>  10

Gly Gly Lys Tyr Cys Glu Gly Arg Arg Thr Arg Phe 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 epitope

<400>  11

Gly Lys Tyr Cys Glu Gly Arg Arg Thr Arg Phe Arg 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 epitope

<400>  12

Lys Tyr Cys Glu Gly Arg Arg Thr Arg Phe Arg Ser 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  237-53 epitope

<400>  13

Tyr Cys Glu Gly Arg Arg Thr Arg Phe Arg Ser Cys 
1               5                   10          


<210>  14
<211>  4410
<212>  DNA
<213>  Homo sapiens

<400>  14
ggggagaacc cacagggaga cccacagaca catatgcacg agagagacag aggaggaaag       60

agacagagac aaaggcacag cggaagaagg cagagacagg gcaggcacag aagcggccca      120

gacagagtcc tacagaggga gaggccagag aagctgcaga agacacaggc agggagagac      180

aaagatccag gaaaggaggg ctcaggagga gagtttggag aagccagacc cctgggcacc      240

tctcccaagc ccaaggacta agttttctcc atttccttta acggtcctca gcccttctga      300

aaactttgcc tctgaccttg gcaggagtcc aagcccccag gctacagaga ggagctttcc      360

aaagctaggg tgtggaggac ttggtgccct agacggcctc agtccctccc agctgcagta      420

ccagtgccat gtcccagaca ggctcgcatc ccgggagggg cttggcaggg cgctggctgt      480

ggggagccca accctgcctc ctgctcccca ttgtgccgct ctcctggctg gtgtggctgc      540

ttctgctact gctggcctct ctcctgccct cagcccggct ggccagcccc ctcccccggg      600

aggaggagat cgtgtttcca gagaagctca acggcagcgt cctgcctggc tcgggcgccc      660

ctgccaggct gttgtgccgc ttgcaggcct ttggggagac gctgctacta gagctggagc      720

aggactccgg tgtgcaggtc gaggggctga cagtgcagta cctgggccag gcgcctgagc      780

tgctgggtgg agcagagcct ggcacctacc tgactggcac catcaatgga gatccggagt      840

cggtggcatc tctgcactgg gatgggggag ccctgttagg cgtgttacaa tatcgggggg      900

ctgaactcca cctccagccc ctggagggag gcacccctaa ctctgctggg ggacctgggg      960

ctcacatcct acgccggaag agtcctgcca gcggtcaagg tcccatgtgc aacgtcaagg     1020

ctcctcttgg aagccccagc cccagacccc gaagagccaa gcgctttgct tcactgagta     1080

gatttgtgga gacactggtg gtggcagatg acaagatggc cgcattccac ggtgcggggc     1140

taaagcgcta cctgctaaca gtgatggcag cagcagccaa ggccttcaag cacccaagca     1200

tccgcaatcc tgtcagcttg gtggtgactc ggctagtgat cctggggtca ggcgaggagg     1260

ggccccaagt ggggcccagt gctgcccaga ccctgcgcag cttctgtgcc tggcagcggg     1320

gcctcaacac ccctgaggac tcggaccctg accactttga cacagccatt ctgtttaccc     1380

gtcaggacct gtgtggagtc tccacttgcg acacgctggg tatggctgat gtgggcaccg     1440

tctgtgaccc ggctcggagc tgtgccattg tggaggatga tgggctccag tcagccttca     1500

ctgctgctca tgaactgggt catgtcttca acatgctcca tgacaactcc aagccatgca     1560

tcagtttgaa tgggcctttg agcacctctc gccatgtcat ggcccctgtg atggctcatg     1620

tggatcctga ggagccctgg tccccctgca gtgcccgctt catcactgac ttcctggaca     1680

atggctatgg gcactgtctc ttagacaaac cagaggctcc attgcatctg cctgtgactt     1740

tccctggcaa ggactatgat gctgaccgcc agtgccagct gaccttcggg cccgactcac     1800

gccattgtcc acagctgccg ccgccctgtg ctgccctctg gtgctctggc cacctcaatg     1860

gccatgccat gtgccagacc aaacactcgc cctgggccga tggcacaccc tgcgggcccg     1920

cacaggcctg catgggtggt cgctgcctcc acatggacca gctccaggac ttcaatattc     1980

cacaggctgg tggctggggt ccttggggac catggggtga ctgctctcgg acctgtgggg     2040

gtggtgtcca gttctcctcc cgagactgca cgaggcctgt cccccggaat ggtggcaagt     2100

actgtgaggg ccgccgtacc cgcttccgct cctgcaacac tgaggactgc ccaactggct     2160

cagccctgac cttccgcgag gagcagtgtg ctgcctacaa ccaccgcacc gacctcttca     2220

agagcttccc agggcccatg gactgggttc ctcgctacac aggcgtggcc ccccaggacc     2280

agtgcaaact cacctgccag gcccaggcac tgggctacta ctatgtgctg gagccacggg     2340

tggtagatgg gaccccctgt tccccggaca gctcctcggt ctgtgtccag ggccgatgca     2400

tccatgctgg ctgtgatcgc atcattggct ccaagaagaa gtttgacaag tgcatggtgt     2460

gcggagggga cggttctggt tgcagcaagc agtcaggctc cttcaggaaa ttcaggtacg     2520

gatacaacaa tgtggtcact atccccgcgg gggccaccca cattcttgtc cggcagcagg     2580

gaaaccctgg ccaccggagc atctacttgg ccctgaagct gccagatggc tcctatgccc     2640

tcaatggtga atacacgctg atgccctccc ccacagatgt ggtactgcct ggggcagtca     2700

gcttgcgcta cagcggggcc actgcagcct cagagacact gtcaggccat gggccactgg     2760

cccagccttt gacactgcaa gtcctagtgg ctggcaaccc ccaggacaca cgcctccgat     2820

acagcttctt cgtgccccgg ccgacccctt caacgccacg ccccactccc caggactggc     2880

tgcaccgaag agcacagatt ctggagatcc ttcggcggcg cccctgggcg ggcaggaaat     2940

aacctcacta tcccggctgc cctttctggg caccggggcc tcggacttag ctgggagaaa     3000

gagagagctt ctgttgctgc ctcatgctaa gactcagtgg ggaggggctg tgggcgtgag     3060

acctgcccct cctctctgcc ctaatgcgca ggctggccct gccctggttt cctgccctgg     3120

gaggcagtga tgggttagtg gatggaaggg gctgacagac agccctccat ctaaactgcc     3180

ccctctgccc tgcgggtcac aggagggagg gggaaggcag ggagggcctg ggccccagtt     3240

gtatttattt agtatttatt cacttttatt tagcaccagg gaaggggaca aggactaggg     3300

tcctggggaa cctgacccct gacccctcat agccctcacc ctggggctag gaaatccagg     3360

gtggtggtga taggtataag tggtgtgtgt atgcgtgtgt gtgtgtgtga aaatgtgtgt     3420

gtgcttatgt atgaggtaca acctgttctg ctttcctctt cctgaatttt attttttggg     3480

aaaagaaaag tcaagggtag ggtgggcctt cagggagtga gggattatct tttttttttt     3540

ttctttcttt ctttcttttt tttttttgag acagaatctc gctctgtcgc ccaggctgga     3600

gtgcaatggc acaatctcgg ctcactgcat cctccgcctc ccgggttcaa gtgattctca     3660

tgcctcagcc tcctgagtag ctgggattac aggctcctgc caccacgccc ggctaatttt     3720

tgttttgttt tgtttggaga cagagtctcg ctattgtcac cagggctgga atgatttcag     3780

ctcactgcaa ccttcgccac ctgggttcca gcaattctcc tgcctcagcc tcccgagtag     3840

ctgagattat aggcacctac caccacgccc ggctaatttt tgtattttta gtagagacgg     3900

ggtttcacca tgttggccag gctggtctcg aactcctgac cttaggtgat ccactcgcct     3960

tcatctccca aagtgctggg attacaggcg tgagccaccg tgcctggcca cgcccaacta     4020

atttttgtat ttttagtaga gacagggttt caccatgttg gccaggctgc tcttgaactc     4080

ctgacctcag gtaatcgacc tgcctcggcc tcccaaagtg ctgggattac aggtgtgagc     4140

caccacgccc ggtacatatt ttttaaattg aattctacta tttatgtgat ccttttggag     4200

tcagacagat gtggttgcat cctaactcca tgtctctgag cattagattt ctcatttgcc     4260

aataataata cctcccttag aagtttgttg tgaggattaa ataatgtaaa taaagaacta     4320

gcataacact caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      4410


<210>  15
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp 
1               5                   10                  15      


Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser 
            20                  25                  30          


Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser 
        35                  40                  45              


Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro 
    50                  55                  60                  


Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg 
65                  70                  75                  80  


Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu 
                85                  90                  95      


Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu 
            100                 105                 110         


Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu 
        115                 120                 125             


Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp 
    130                 135                 140                 


Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu 
145                 150                 155                 160 


His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro 
                165                 170                 175     


Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro 
            180                 185                 190         


Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg 
        195                 200                 205             


Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg 
225                 230                 235                 240 


Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro 
                245                 250                 255     


Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu 
            260                 265                 270         


Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr 
        275                 280                 285             


Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp 
    290                 295                 300                 


Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly 
            340                 345                 350         


Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu 
    370                 375                 380                 


Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro 
385                 390                 395                 400 


Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu 
                405                 410                 415     


Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu 
            420                 425                 430         


His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln 
        435                 440                 445             


Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro 
    450                 455                 460                 


Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala 
465                 470                 475                 480 


Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly 
                485                 490                 495     


Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu 
            500                 505                 510         


Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro 
        515                 520                 525             


Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
545                 550                 555                 560 


Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr 
                565                 570                 575     


Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His 
            580                 585                 590         


Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro 
        595                 600                 605             


Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln 
    610                 615                 620                 


Ala Gln Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp 
625                 630                 635                 640 


Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg 
                645                 650                 655     


Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe 
            660                 665                 670         


Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln 
        675                 680                 685             


Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr 
    690                 695                 700                 


Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro 
705                 710                 715                 720 


Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr 
                725                 730                 735     


Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val 
            740                 745                 750         


Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser 
        755                 760                 765             


Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln 
    770                 775                 780                 


Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe 
785                 790                 795                 800 


Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp 
                805                 810                 815     


Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro 
            820                 825                 830         


Trp Ala Gly Arg Lys 
        835         


<210>  16
<211>  9663
<212>  DNA
<213>  Homo sapiens

<400>  16
ataaattcat tgttccacct cctcgcatct tcacagcgct cgcgctgctc tcggcgctcg       60

cagctgccga ctggggatga cggcgggcag gaggagaccg cagccgaagg gacacagaca      120

cgccgcttca ccagctcgcc tcaggctgcc cccctgcatt tttgttttaa tttttacggc      180

tttttcccct ctctttcttc ccttcctcct ggtcccagca gagccaagga aacccacaaa      240

ataagaaagg aagtgggccc cggagcttgg aacctccaca gccggcttgt ccagcgcagc      300

gcgggggcgg gaggctgcgc gcaccagttg ccagcccggt gcgcggtacc tttccttact      360

tttcttgaaa cagcgatcgt gcctgcattt ggtggttttt tggtttttgt ttttttcctt      420

ttcccgtatt tgctgaatct ccactatccg actttttttt tttaatcttt tctttccccc      480

cccccccacc ccacctcttt ctggagcacg aatccaaaca ttttcccaag caacaaagaa      540

aagttcgcac gctggcaccg cagcccggac aggctggcgc tgctgccggg cccccctccc      600

tccgacactt gactcaatcc tgcaagcaag tgtgtgtgtg tccccatccc ccgccccgtt      660

aacttcatag caaataacaa atacccataa agtcccagtc gcgcagcccc tccccgcggg      720

cagcgcacta tgctgctcgg gtgggcgtcc ctgctgctgt gcgcgttccg cctgcccctg      780

gccgcggtcg gccccgccgc gacacctgcc caggataaag ccgggcagcc tccgactgct      840

gcagcagccg cccagccccg ccggcggcag ggggaggagg tgcaggagcg agccgagcct      900

cccggccacc cgcaccccct ggcgcagcgg cgcaggagca aggggctggt gcagaacatc      960

gaccaactct actccggcgg cggcaaggtg ggctacctcg tctacgcggg cggccggagg     1020

ttcctcttgg acctggagcg agatggttcg gtgggcattg ctggcttcgt gcccgcagga     1080

ggcgggacga gtgcgccctg gcgccaccgg agccactgct tctatcgggg cacagtggac     1140

ggtagtcccc gctctctggc tgtctttgac ctctgtgggg gtctcgacgg cttcttcgcg     1200

gtcaagcacg cgcgctacac cctaaagcca ctgctgcgcg gaccctgggc ggaggaagaa     1260

aaggggcgcg tgtacgggga tgggtccgca cggatcctgc acgtctacac ccgcgagggc     1320

ttcagcttcg aggccctgcc gccgcgcgcc agctgcgaaa cccccgcgtc cacaccggag     1380

gcccacgagc atgctccggc gcacagcaac ccgagcggac gcgcagcact ggcctcgcag     1440

ctcttggacc agtccgctct ctcgcccgct gggggctcag gaccgcagac gtggtggcgg     1500

cggcggcgcc gctccatctc ccgggcccgc caggtggagc tgcttctggt ggctgacgcg     1560

tccatggcgc ggttgtatgg ccggggcctg cagcattacc tgctgaccct ggcctccatc     1620

gccaataggc tgtacagcca tgctagcatc gagaaccaca tccgcctggc cgtggtgaag     1680

gtggtggtgc taggcgacaa ggacaagagc ctggaagtga gcaagaacgc tgccaccaca     1740

ctcaagaact tttgcaagtg gcagcaccaa cacaaccagc tgggagatga ccatgaggag     1800

cactacgatg cagctatcct gtttactcgg gaggatttat gtgggcatca ttcatgtgac     1860

accctgggaa tggcagacgt tgggaccata tgttctccag agcgcagctg tgctgtgatt     1920

gaagacgatg gcctccacgc agccttcact gtggctcacg aaatcggaca tttacttggc     1980

ctctcccatg acgattccaa attctgtgaa gagacctttg gttccacaga agataagcgc     2040

ttaatgtctt ccatccttac cagcattgat gcatctaagc cctggtccaa atgcacttca     2100

gccaccatca cagaattcct ggatgatggc catggtaact gtttgctgga cctaccacga     2160

aagcagatcc tgggccccga agaactccca ggacagacct acgatgccac ccagcagtgc     2220

aacctgacat tcgggcctga gtactccgtg tgtcccggca tggatgtctg tgctcgcctg     2280

tggtgtgctg tggtacgcca gggccagatg gtctgtctga ccaagaagct gcctgcggtg     2340

gaagggacgc cttgtggaaa ggggagaatc tgcctgcagg gcaaatgtgt ggacaaaacc     2400

aagaaaaaat attattcaac gtcaagccat ggcaactggg gatcttgggg atcctggggc     2460

cagtgttctc gctcatgtgg aggaggagtg cagtttgcct atcgtcactg taataaccct     2520

gctcccagaa acaacggacg ctactgcaca gggaagaggg ccatctaccg ctcctgcagt     2580

ctcatgccct gcccacccaa tggtaaatca tttcgtcatg aacagtgtga ggccaaaaat     2640

ggctatcagt ctgatgcaaa aggagtcaaa acttttgtgg aatgggttcc caaatatgca     2700

ggtgtcctgc cagcggatgt gtgcaagctg acctgcagag ccaagggcac tggctactat     2760

gtggtatttt ctccaaaggt gaccgatggc actgaatgta ggctgtacag taattccgtc     2820

tgcgtccggg ggaagtgtgt gagaactggc tgtgacggca tcattggctc aaagctgcag     2880

tatgacaagt gcggagtatg tggaggagac aactccagct gtacaaagat tgttggaacc     2940

tttaataaga aaagtaaggg ttacactgac gtggtgagga ttcctgaagg ggcaacccac     3000

ataaaagttc gacagttcaa agccaaagac cagactagat tcactgccta tttagccctg     3060

aaaaagaaaa acggtgagta ccttatcaat ggaaagtaca tgatctccac ttcagagact     3120

atcattgaca tcaatggaac agtcatgaac tatagcggtt ggagccacag ggatgacttc     3180

ctgcatggca tgggctactc tgccacgaag gaaattctaa tagtgcagat tcttgcaaca     3240

gaccccacta aaccattaga tgtccgttat agcttttttg ttcccaagaa gtccactcca     3300

aaagtaaact ctgtcactag tcatggcagc aataaagtgg gatcacacac ttcgcagccg     3360

cagtgggtca cgggcccatg gctcgcctgc tctaggacct gtgacacagg ttggcacacc     3420

agaacggtgc agtgccagga tggaaaccgg aagttagcaa aaggatgtcc tctctcccaa     3480

aggccttctg cgtttaagca atgcttgttg aagaaatgtt agcctgtggt tatgatctta     3540

tgcacaaaga taactggagg attcagcact gatgcagtcg tggtgaacag gaggtctacc     3600

taacgcacag aaagtcatgc ttcagtgaca ttgtcaacag gagtccaatt atgggcagaa     3660

tctgctctct gtgaccaaaa gaggatgtgc actgcttcac gtgacagtgg tgaccttgca     3720

atatagaaaa acttgggagt tattgaacat cccctgggct tacaagaaac actgatgaat     3780

gtaaaatcag gggacatttg aagatggcag aactgtctcc cccttgtcac ctacctctga     3840

tagaatgtct ttaatggtat cataatcatt ttcacccata atacacagta gcttcttctt     3900

actgtttgta aatacattct cccttggtat gtcactttat atcccctggt tctattaaaa     3960

tatccatata tatttctata aaaaaagtgt ttgaccaaag taggtctgca gctatttcaa     4020

cttccttccg tttccagaaa gagctgtgga tattttactg gaaattaaga acttgctgct     4080

gttttaataa gatgtagtat attttctgac tacaggagat aaaatttcag tcaaaaaacc     4140

attttgacag caagtatctt ctgagaaatt ttgaaaagta aatagatctc agtgtatcta     4200

gtcacttaaa tacatacacg ggttcattta cttaaacctt tgactgcctg tatttttttc     4260

aggtagctag ccaaattaat gcataatttc agatgtagaa gtagggtttg cgtgtgtgtg     4320

tgtgatcata ctcaagagtc taaaaactag tttccttgtg ttggaaattt aaaaggaaaa     4380

aaatcgtatt tcactgtgtt ttcaatttat attttcacaa ctactttctc tctccagagc     4440

tttcatctga tatctcacaa tgtatgatat acgtacaaaa cacacagcaa gttttctatc     4500

atgtccaaca cattcaacac tggtatacct cctaccagca agcctttaaa atgcatttgt     4560

gtttgcttat ttgttttgtt caagggttca gtaagaccta caatgttttg tatttcttga     4620

cttattttat tagaaacatt aaagatcact tggtagttag ccacattgag aagtggttat     4680

cattgttaat gtggttaatg ccaaaaagtg gttaatatta ataagactgt ttccacacca     4740

taggcaataa tttcttaatt taaaaaatct aagtatattc ctattgtact aaatattttt     4800

cccaactgga aagcacttga ttgtacccgt aagtgtttga gtgatgacat gtgatgattt     4860

tcagaaagtt gttgtttttg tttccatagc ctgtttaagt aggttgtaag tttgaatagt     4920

tagacatgga aattatttta taagcacaca cctaaagata tctttttaga tgataaaatg     4980

tacacccccc catcaccaac ctcacaactt agaaaatcta agttgtttga tttctttggg     5040

atttcttttg ttgtgaaaca ctgcaaagcc aatttttctt tataaaaatt catagtaatc     5100

ctgccaaatg tgcctattgt taaagatttg catgtgaaga tcttagggaa ccactgtttg     5160

agttctacaa gctcatgaga gtttattttt attataagat gtttttaata taaaagaatt     5220

atgtaactga tcactatatt acatcatttc agtgggccag gaaaatagat gtcttgctgt     5280

tttcagtatt ttcttaagaa attgctttta aaacaaataa ttgttttaca aaaccaataa     5340

ttatcctttg aattttcata gactgacttt gcttttgacg tagaaatttt ttttctcaat     5400

aaattatcac tttgagaaat gaggcctgta caaggctgat aacctatatg tgatggagat     5460

cacccaatgc caagggcaga aagcaaacct agttaaatag gtgagaaaaa aaataataat     5520

cccagtgcca tttgtctgtg caaagagaat taggagagag gttaatgtta cttttttcca     5580

ttttggaaat aattttaatc aagtaactca aatgtgacaa aatttatttt tattttttgt     5640

ggttatattc ccaacaacat taaaaaatac tcgaggcata aatgtagttg tctcctactc     5700

tgcttctctt actatactca tacattttta atatggttta tcaatgattc atgtttccct     5760

caaatagtga tggtttacac ctgtcatgga aacaatccta gagagctcag agcaattaaa     5820

ccactattcc atgcttttaa gtagttttct ccaccttttt cttatgagtc tcactagatt     5880

gactgaggaa tgtatgtcta aattcctgga gaagatgata tggattggaa actgaaattc     5940

agagaaatgg agtgttcaat agataccacg aattgtgaac aaagggaaaa ttctatacaa     6000

ctcaatctaa gtcagtccac tttgacttcg tactgtcttt cacctttcca ttgttgcatc     6060

ttgaattttt taaaatgtct agaattcagg atgctagggg ctacttcttt aaaaaaaaaa     6120

aaaaaaaaga attcgtctga aaatgctcag gtttgtaaga atctaatctc acttacataa     6180

ctaagcactc cataataagt tttattaagt acaaagggag ccagaaaaaa tgacatttat     6240

ttcttctaga tcagaaaaat ttaaattaag ccctgccttg ctgtttagaa atatgtgggc     6300

attgttataa tttattcaat aaatttatgt tcctttgcct tcctgtggaa acagttttat     6360

cccactaaac taggaattag gggataaatc acaaacaaaa aaaaagttgc agcactgaaa     6420

aaaagtaatt tattgttttt gcaactggta tgtgaatttg tgtgataaaa ttatttattc     6480

ttatttaaca aaaatatgtt caaatttttc tatatttaaa atgttttgct gttgtcctac     6540

tttttaattt atgcttcatg tttgtgtata aagtacactt ttacactttg tgagtttaca     6600

taatatacag cactggttgc ttttgtattt ttttacagaa agctttctgt gtgaagcagg     6660

tgtatatgta tatattcctc atgtattctt attctgatac tatcattttt ctttccaagg     6720

aaattttaat ctgtcatgac caatagtgtt cattacttgt gcctatgata ataggttttt     6780

tacatcacat taacactatt ttttccaagt cacaaataag aaaaacactt attcaatgaa     6840

acaaggtgca agttttaaat ttgggtacac aaatagccta gaagcttcct acagacgcta     6900

agacacagcc aataatcaga tcctttcact tcatcgagaa acttggacaa gtcgatattg     6960

atgtattaga tgaaagttgt ctacacacaa cttctgaggg atacaaacga taataaaacc     7020

aaatgttgtc tgtttctcct ttagaaacac ctcctaaaat taatatcatt tagtctctag     7080

tgtctgtagg attctacaga tgagcacaaa tagattgggt ttgtataaca aatgctaata     7140

gtcataactg tttctacaaa tatggggtgt ccattaagag aatgtgatgt tttcctactg     7200

ctgttgaatc ccatggggtg attataggac ttgaaatagg cagagtcacc tctgatgaca     7260

tcagcttgcc tctgtgattt cacagtctga tcctggcaac aagacaaagc acccttggac     7320

acacagccaa tctctggttg tgatatttcc ccattgattc cttccttgtt aacaaggtca     7380

ttttaatggt tcaggtgagg acagcagcca gattcaaagt ccagaatttg tgctgttaca     7440

tagagttcac actgtcaaat aacattgaat ttaataatga tcaaattttt ctagtagtct     7500

ttggcagagt gtataatctc attggcatga ttggtgaata ttactaatct ctttataatg     7560

aaagatgctt tacaaatacc ttatatttgc taacatttca aaactactaa ataaatgaaa     7620

tagccatgtg tacagaaatg gtcatttaaa gctttaatag aaccaaattc aagacaatgt     7680

atcatttaga cacacagaaa aggaacttgt atgttttccc tattattttt ctcatttgcc     7740

aacaatctat agttttaggt tatcaaacag atagatcaac ttaactggct agtacattga     7800

aaaatcttcc taagaatcct ttgttagcat aatctataga gataatttct caaattatat     7860

catcatgatg catataaact ctataatgta taattgtgtt tcatttattt aatgtatgag     7920

aacatattga aatacaaaac catgcattag ccaaaaaatt ggaatacagg tagtgttcag     7980

atcagcaaaa cattcagtct ggtaaatgcc tgcctggggc tatgatatca ttctcaatgc     8040

aggttttatg gaaaaactaa aagaatatgt tgttagatga tgttggtttt gaaaaaaaaa     8100

agacattaac atacacatta gttagcccag ttaattgcat tctactaata tagttgcaca     8160

ttagcaataa ttttgctgtc tctggtcttt attttgtggc ttcaactaac tggaccatgt     8220

ggactgtaaa ggtcaaatgg aaaaaacgag cagtggcccc tcatcctgta aggtactgct     8280

acatcagagt gacctaaaag tctaacactg tgaggaaaac tgtgatttgt aggaaaaaaa     8340

aaaaaaacaa ataaaaaaca gggcatgctt tttaattttt ttccactttc ctttggcaca     8400

cccaatgaac aattctaatt tttattgagg tgctaacatc tttcgtgacc gactgtcaaa     8460

tgtggtattt ttgagttact atttttctac atgattttac agtttgcaag aaagacctct     8520

aagctttgtg tcacggtagg gcacaacttg atactcaaaa tttgaaaaat aagcacatcc     8580

aatgattgtt ttgaccaaca gtggtcagtg acgtaaactg catgtgcatc tgaggacatt     8640

taaggggtca ttaaaatttg aggagcatca ggccggagta gcagactttt agatgagtca     8700

tatttcagca ttcactaagt cctcagcatt ccattcaaac tgtcgtgtat atttggcctg     8760

attttttttc aagctttgca ataatttatg ttattggtaa acacttggtg actatatctc     8820

agccttttct ttaacaactc acaatatatt agaaacacgt ctacctatac tgagagtata     8880

tttacaatag aagaacatac tgtatgtgac tttgtaaagc tagacttttg attaagaaat     8940

atataatctc tggatgctat ttttgcatta tacactcagg cacaacgtaa accttgatgg     9000

ctcatcttgc tacaattacg agttgaaaaa cactacttac gtatttgtat gacctattag     9060

tcagaggaaa tcatacatat gctttgtaaa tagactttgc agataactaa atagactgaa     9120

gaaatatgtt gcatttgata gaagcaattg cataaatatt tggtttctat attagagtct     9180

gtgagtaaag tcaagtaata aacctaagta ggtataacag atttttaaac cttgaaactt     9240

gctttgatgg tagagaaaat cattgaagat ttacatactg tatataagat gtaaaatgta     9300

cgctgcttat taccctcaat tttccagaag caatggtata taatgcagtt gaaaaaccaa     9360

aaatcttgga aaactaagac gggtcttgtt taaaatgtct ctcagctttg gcaaccttca     9420

aatcttaatc aactatttaa agcattactg tgtcttgtag cctgcattcc acaacagctc     9480

tgttattcag gtaaaagact tgaactgagc cgtttgggac ctatactgta atattttcat     9540

tgaggaacaa tatcctattt tgtaaagcat ttccctatgt gtgactttaa actgtaaaat     9600

taaacactgc ttttgtgggt tcagtgggca taataaatat aaattgtaaa ctaggttaaa     9660

gta                                                                   9663


<210>  17
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  18

Ala Gly Gly Trp Gly Pro Trp Gly Pro Trp Gly Asp 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  19

Gly Gly Trp Gly Pro Trp Gly Pro Trp Gly Asp Cys 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  20

Gly Trp Gly Pro Trp Gly Pro Trp Gly Asp Cys Ser 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  21

Trp Gly Pro Trp Gly Pro Trp Gly Asp Cys Ser Arg 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  22

Gly Pro Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  23

Pro Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  24

Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  25

Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  26

Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  27

Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  28

Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  29

Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  30

Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  31

Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  32

Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser Arg 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  33

Thr Cys Gly Gly Gly Val Gln Phe Ser Ser Arg Asp 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  34

Cys Gly Gly Gly Val Gln Phe Ser Ser Arg Asp Cys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  35

Gly Gly Gly Val Gln Phe Ser Ser Arg Asp Cys Thr 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  36

Gly Gly Val Gln Phe Ser Ser Arg Asp Cys Thr Arg 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  37

Gly Val Gln Phe Ser Ser Arg Asp Cys Thr Arg Pro 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  38

Val Gln Phe Ser Ser Arg Asp Cys Thr Arg Pro Val 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  39

Gln Phe Ser Ser Arg Asp Cys Thr Arg Pro Val Pro 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  40

Phe Ser Ser Arg Asp Cys Thr Arg Pro Val Pro Arg 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  41

Ser Ser Arg Asp Cys Thr Arg Pro Val Pro Arg Asn 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  42

Ser Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  43

Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  44

Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  45

Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  46

Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  47

Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  48

Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu Gly 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  49

Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu Gly Arg 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  50

Pro Arg Asn Gly Gly Lys Tyr Cys Glu Gly Arg Arg 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  51

Arg Asn Gly Gly Lys Tyr Cys Glu Gly Arg Arg Thr 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  52

Asn Gly Gly Lys Tyr Cys Glu Gly Arg Arg Thr Arg 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  53

Cys Glu Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  54

Glu Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  55

Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  56

Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  57

Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide of human ADAMTS4

<400>  58

Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro 
1               5                   10          


