                         SEQUENCE LISTING



<110>  Kyushu University

       Hitachi Aloka Medical , LTD.

 

<120>  Fusion protein for detecting protein and detection method of 

       protein



<130>  AL10624WO


<150>  JP 2013-217048

<151>  2013-10-18



<160>  14    



<170>  PatentIn version 3.5



<210>  1

<211>  666

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  1



Ala Asp Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu 

1               5                   10                  15      





Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys 

            20                  25                  30          





Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp 

        35                  40                  45              





Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala 

    50                  55                  60                  





Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly 

65                  70                  75                  80  





Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu Thr 

                85                  90                  95      





Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly 

            100                 105                 110         





Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly 

        115                 120                 125             





Gly Gly Gly Ser Asp Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn 

    130                 135                 140                 





Ala Phe Trp Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg 

145                 150                 155                 160 





Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 

                165                 170                 175     





Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly 

            180                 185                 190         





Gly Gly Gly Ser Thr Pro Glu Met Pro Val Leu Glu Asn Arg Ala Ala 

        195                 200                 205             





Gln Gly Asp Ile Thr Ala Pro Gly Gly Ala Arg Arg Leu Thr Gly Asp 

    210                 215                 220                 





Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys Pro Ala Lys Asn 

225                 230                 235                 240 





Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp Ser Glu Ile Thr Ala 

                245                 250                 255     





Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe Lys Gly Ile Asp 

            260                 265                 270         





Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala Leu Asn Lys Lys 

        275                 280                 285             





Thr Gly Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala Ser Ala Thr Ala 

    290                 295                 300                 





Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu Gly Val Asp Ile 

305                 310                 315                 320 





His Glu Lys Asp His Pro Thr Ile Leu Glu Met Ala Lys Ala Ala Gly 

                325                 330                 335     





Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu Gln Gly Ala Thr Pro 

            340                 345                 350         





Ala Ala Leu Val Ala His Val Thr Ser Arg Lys Cys Tyr Gly Pro Ser 

        355                 360                 365             





Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu Lys Gly Gly Lys 

    370                 375                 380                 





Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala Asp Val Thr Leu 

385                 390                 395                 400 





Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr Ala Gly Glu Trp 

                405                 410                 415     





Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg Gly Tyr Gln Leu 

            420                 425                 430         





Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr Glu Ala Asn Gln Gln 

        435                 440                 445             





Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn Met Pro Val Arg Trp 

    450                 455                 460                 





Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile Asp Lys Pro Ala Val 

465                 470                 475                 480 





Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser Val Pro Thr Leu Ala 

                485                 490                 495     





Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys Asn Glu Lys Gly 

            500                 505                 510         





Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp Lys Gln Asn His Ala 

        515                 520                 525             





Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val Asp Leu Asp Glu Ala 

    530                 535                 540                 





Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Glu Gly Asn Thr Leu Val 

545                 550                 555                 560 





Ile Val Thr Ala Asp His Ala His Ala Ser Gln Ile Val Ala Pro Asp 

                565                 570                 575     





Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr Lys Asp Gly Ala 

            580                 585                 590         





Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu Asp Ser Gln Glu His 

        595                 600                 605             





Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro His Ala Ala Asn 

    610                 615                 620                 





Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr Thr Met Lys Ala 

625                 630                 635                 640 





Ala Leu Gly Leu Lys Leu Glu Gly Ser His His His His His His Gly 

                645                 650                 655     





Gly Gly Gly Ser Met Arg His Lys Gly Ser 

            660                 665     





<210>  2

<211>  1998

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  2

gcagatacgt ataaactcgt catcaacggt aaaacgttaa aaggcgaaac taccactgaa       60



gctgttgatg ctgctacggc agaaaaagtg ttcaaacagt acgcgaatga caatggcgtg      120



gatggcgagt ggacttacga tgacgcgact aaaactttca ccgttaccga aaagccggaa      180



gtaattgacg cttccgaact gaccccggca gtcacgactt acaaattggt cattaacggg      240



aaaaccctta aaggggaaac caccactaag gcggttgacg cggaaacggc cgagaaagcg      300



ttcaagcagt atgctaacga caatggtgtt gatggcgtgt ggacctatga tgatgctaca      360



aaaacattta cggtgaccga aggtggcggc ggttccgatg tcgacaataa gttcaataaa      420



gagcagcaga acgccttctg ggagattctc cacctcccga atctgaacga ggagcagcgt      480



aacggtttta ttcaatctct gaaagacgat ccgtcacaga gcgctaacct gctggcagaa      540



gcaaaaaaat taaatgatgc ccaggcgccg aaaggcggtg ggggatccac gcccgaaatg      600



cccgtgttgg agaaccgcgc tgcacagggt gatatcacgg ccccaggcgg tgcccgtcgc      660



ctcacgggag accaaaccgc agccttgcgt gacagccttt ccgataaacc tgcaaaaaac      720



attatcttgc ttattggcga cggtatgggc gattccgaaa ttacggccgc gcgcaattat      780



gccgaaggcg ctggtggctt cttcaagggg attgatgcgt taccactgac agggcagtac      840



actcactacg cgctcaacaa aaaaaccggt aagccagatt acgtaaccga ctctgctgcg      900



agcgccacag cctggtcaac tggtgtgaaa acttataacg gcgccttagg cgtcgacatt      960



cacgaaaaag atcacccgac gattctggaa atggcgaaag cggccggtct ggcgacggga     1020



aacgtgtcta cggcggaact ccagggcgcg acgcccgccg cactggtggc ccatgtgacc     1080



tctcgtaagt gctacggccc tagtgcgacc tcggagaaat gcccaggcaa tgctctggaa     1140



aaagggggca agggttctat tactgagcag ctgctgaatg cgcgcgctga tgtgacgctg     1200



ggtggcggag caaaaacctt tgccgaaacc gccactgccg gtgagtggca ggggaaaact     1260



ctgcgcgaac aggcgcaagc ccgcggatat caactggtgt ctgatgcggc gtcgctgaac     1320



tccgtaaccg aagcgaacca gcagaaaccg cttctgggtc tgttcgcaga tggcaatatg     1380



cctgtgcgtt ggctggggcc caaagcaacg tatcacggca acatcgataa gcctgctgta     1440



acgtgtacgc cgaacccgca gcgtaatgat agtgtaccga cactcgcgca gatgaccgat     1500



aaagcaatcg agctgctgtc gaagaacgaa aaaggttttt tcctgcaagt tgagggcgcg     1560



agcattgata aacagaacca tgccgctaac ccctgcggcc agatcgggga aacggttgat     1620



ctggatgagg ctgtacagcg tgctctggaa tttgcgaaaa aagagggtaa taccttagtg     1680



attgttaccg cagaccacgc acacgctagc cagatcgttg caccggacac taaggcaccg     1740



ggcctgaccc aggctctgaa caccaaggac ggggcggtta tggttatgtc ctatggtaac     1800



tcggaagagg actcccaaga acataccggt tcgcaattac gcatcgcggc gtatggtccg     1860



catgcagcga acgtagtggg tctgaccgat cagaccgatc tgttctatac aatgaaagcc     1920



gcgttgggac tcaaactgga gggatcccat catcatcacc atcacggtgg cggtggtagc     1980



atgcgccata aaggctcg                                                   1998





<210>  3

<211>  666

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  3



Ala Asp Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu 

1               5                   10                  15      





Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys 

            20                  25                  30          





Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp 

        35                  40                  45              





Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala 

    50                  55                  60                  





Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly 

65                  70                  75                  80  





Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu Thr 

                85                  90                  95      





Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly 

            100                 105                 110         





Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly 

        115                 120                 125             





Gly Gly Gly Ser Asp Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn 

    130                 135                 140                 





Ala Phe Trp Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg 

145                 150                 155                 160 





Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 

                165                 170                 175     





Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly 

            180                 185                 190         





Gly Gly Gly Ser Thr Pro Glu Met Pro Val Leu Glu Asn Arg Ala Ala 

        195                 200                 205             





Gln Gly Asp Ile Thr Ala Pro Gly Gly Ala Arg Arg Leu Thr Gly Asp 

    210                 215                 220                 





Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys Pro Ala Lys Asn 

225                 230                 235                 240 





Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp Ser Glu Ile Thr Ala 

                245                 250                 255     





Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe Lys Gly Ile Asp 

            260                 265                 270         





Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala Leu Asn Lys Lys 

        275                 280                 285             





Thr Gly Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala Ser Ala Thr Ala 

    290                 295                 300                 





Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu Gly Val Asp Ile 

305                 310                 315                 320 





His Glu Lys Asp His Pro Thr Ile Leu Glu Met Ala Lys Ala Ala Gly 

                325                 330                 335     





Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu Gln His Ala Thr Pro 

            340                 345                 350         





Ala Ala Leu Val Ala His Val Thr Ser Arg Lys Cys Tyr Gly Pro Ser 

        355                 360                 365             





Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu Lys Gly Gly Lys 

    370                 375                 380                 





Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala Asp Val Thr Leu 

385                 390                 395                 400 





Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr Ala Gly Glu Trp 

                405                 410                 415     





Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg Gly Tyr Gln Leu 

            420                 425                 430         





Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr Glu Ala Asn Gln Gln 

        435                 440                 445             





Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn Met Pro Val Arg Trp 

    450                 455                 460                 





Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile Asp Lys Pro Ala Val 

465                 470                 475                 480 





Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser Val Pro Thr Leu Ala 

                485                 490                 495     





Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys Asn Glu Lys Gly 

            500                 505                 510         





Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp Lys Gln Asn His Ala 

        515                 520                 525             





Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val Asp Leu Asp Glu Ala 

    530                 535                 540                 





Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Glu Gly Asn Thr Leu Val 

545                 550                 555                 560 





Ile Val Thr Ala Asp His Ala His Ala Ser Gln Ile Val Ala Pro Asp 

                565                 570                 575     





Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr Lys Asp Gly Ala 

            580                 585                 590         





Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu Asp Ser Gln Glu His 

        595                 600                 605             





Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro His Ala Ala Asn 

    610                 615                 620                 





Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr Thr Met Lys Ala 

625                 630                 635                 640 





Ala Leu Gly Leu Lys Leu Glu Gly Ser His His His His His His Gly 

                645                 650                 655     





Gly Gly Gly Ser Met Arg His Lys Gly Ser 

            660                 665     





<210>  4

<211>  1998

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  4

gcagatacgt ataaactcgt catcaacggt aaaacgttaa aaggcgaaac taccactgaa       60



gctgttgatg ctgctacggc agaaaaagtg ttcaaacagt acgcgaatga caatggcgtg      120



gatggcgagt ggacttacga tgacgcgact aaaactttca ccgttaccga aaagccggaa      180



gtaattgacg cttccgaact gaccccggca gtcacgactt acaaattggt cattaacggg      240



aaaaccctta aaggggaaac caccactaag gcggttgacg cggaaacggc cgagaaagcg      300



ttcaagcagt atgctaacga caatggtgtt gatggcgtgt ggacctatga tgatgctaca      360



aaaacattta cggtgaccga aggtggcggc ggttccgatg tcgacaataa gttcaataaa      420



gagcagcaga acgccttctg ggagattctc cacctcccga atctgaacga ggagcagcgt      480



aacggtttta ttcaatctct gaaagacgat ccgtcacaga gcgctaacct gctggcagaa      540



gcaaaaaaat taaatgatgc ccaggcgccg aaaggcggtg ggggatccac gcccgaaatg      600



cccgtgttgg agaaccgcgc tgcacagggt gatatcacgg ccccaggcgg tgcccgtcgc      660



ctcacgggag accaaaccgc agccttgcgt gacagccttt ccgataaacc tgcaaaaaac      720



attatcttgc ttattggcga cggtatgggc gattccgaaa ttacggccgc gcgcaattat      780



gccgaaggcg ctggtggctt cttcaagggg attgatgcgt taccactgac agggcagtac      840



actcactacg cgctcaacaa aaaaaccggt aagccagatt acgtaaccga ctctgctgcg      900



agcgccacag cctggtcaac tggtgtgaaa acttataacg gcgccttagg cgtcgacatt      960



cacgaaaaag atcacccgac gattctggaa atggcgaaag cggccggtct ggcgacggga     1020



aacgtgtcta cggcggaact ccagcatgcg acgcccgccg cactggtggc ccatgtgacc     1080



tctcgtaagt gctacggccc tagtgcgacc tcggagaaat gcccaggcaa tgctctggaa     1140



aaagggggca agggttctat tactgagcag ctgctgaatg cgcgcgctga tgtgacgctg     1200



ggtggcggag caaaaacctt tgccgaaacc gccactgccg gtgagtggca ggggaaaact     1260



ctgcgcgaac aggcgcaagc ccgcggatat caactggtgt ctgatgcggc gtcgctgaac     1320



tccgtaaccg aagcgaacca gcagaaaccg cttctgggtc tgttcgcaga tggcaatatg     1380



cctgtgcgtt ggctggggcc caaagcaacg tatcacggca acatcgataa gcctgctgta     1440



acgtgtacgc cgaacccgca gcgtaatgat agtgtaccga cactcgcgca gatgaccgat     1500



aaagcaatcg agctgctgtc gaagaacgaa aaaggttttt tcctgcaagt tgagggcgcg     1560



agcattgata aacagaacca tgccgctaac ccctgcggcc agatcgggga aacggttgat     1620



ctggatgagg ctgtacagcg tgctctggaa tttgcgaaaa aagagggtaa taccttagtg     1680



attgttaccg cagaccacgc acacgctagc cagatcgttg caccggacac taaggcaccg     1740



ggcctgaccc aggctctgaa caccaaggac ggggcggtta tggttatgtc ctatggtaac     1800



tcggaagagg actcccaaga acataccggt tcgcaattac gcatcgcggc gtatggtccg     1860



catgcagcga acgtagtggg tctgaccgat cagaccgatc tgttctatac aatgaaagcc     1920



gcgttgggac tcaaactgga gggatcccat catcatcacc atcacggtgg cggtggtagc     1980



atgcgccata aaggctcg                                                   1998





<210>  5

<211>  666

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  5



Ala Asp Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu 

1               5                   10                  15      





Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys 

            20                  25                  30          





Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp 

        35                  40                  45              





Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala 

    50                  55                  60                  





Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly 

65                  70                  75                  80  





Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu Thr 

                85                  90                  95      





Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly 

            100                 105                 110         





Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly 

        115                 120                 125             





Gly Gly Gly Ser Asp Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn 

    130                 135                 140                 





Ala Phe Trp Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg 

145                 150                 155                 160 





Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 

                165                 170                 175     





Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly 

            180                 185                 190         





Gly Gly Gly Ser Thr Pro Glu Met Pro Val Leu Glu Asn Arg Ala Ala 

        195                 200                 205             





Gln Gly Asp Ile Thr Ala Pro Gly Gly Ala Arg Arg Leu Thr Gly Asp 

    210                 215                 220                 





Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys Pro Ala Lys Asn 

225                 230                 235                 240 





Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp Ser Glu Ile Thr Ala 

                245                 250                 255     





Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe Lys Gly Ile Asp 

            260                 265                 270         





Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala Leu Asn Lys Lys 

        275                 280                 285             





Thr Gly Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala Ser Ala Thr Ala 

    290                 295                 300                 





Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu Gly Val Asp Ile 

305                 310                 315                 320 





His Glu Lys Asp His Pro Thr Ile Leu Glu Met Ala Lys Ala Ala Gly 

                325                 330                 335     





Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu Gln Asp Ala Thr Pro 

            340                 345                 350         





Ala Ala Leu Val Ala His Val Thr Ser Arg Lys Cys Tyr Gly Pro Ser 

        355                 360                 365             





Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu Lys Gly Gly Lys 

    370                 375                 380                 





Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala Asp Val Thr Leu 

385                 390                 395                 400 





Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr Ala Gly Glu Trp 

                405                 410                 415     





Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg Gly Tyr Gln Leu 

            420                 425                 430         





Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr Glu Ala Asn Gln Gln 

        435                 440                 445             





Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn Met Pro Val Arg Trp 

    450                 455                 460                 





Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile Asp Lys Pro Ala Val 

465                 470                 475                 480 





Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser Val Pro Thr Leu Ala 

                485                 490                 495     





Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys Asn Glu Lys Gly 

            500                 505                 510         





Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp Arg Gln Asn His Ala 

        515                 520                 525             





Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val Asp Leu Asp Glu Ala 

    530                 535                 540                 





Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Glu Gly Asn Thr Leu Val 

545                 550                 555                 560 





Ile Val Thr Ala Asp His Ala His Ala Ser Gln Ile Val Ala Pro Asp 

                565                 570                 575     





Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr Lys Asp Gly Ala 

            580                 585                 590         





Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu Asp Ser Gln Glu His 

        595                 600                 605             





Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro His Ala Ala Asn 

    610                 615                 620                 





Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr Thr Met Lys Ala 

625                 630                 635                 640 





Ala Leu Gly Leu Lys Leu Glu Gly Ser His His His His His His Gly 

                645                 650                 655     





Gly Gly Gly Ser Met Arg His Lys Gly Ser 

            660                 665     





<210>  6

<211>  1998

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  6

gcagatacgt ataaactcgt catcaacggt aaaacgttaa aaggcgaaac taccactgaa       60



gctgttgatg ctgctacggc agaaaaagtg ttcaaacagt acgcgaatga caatggcgtg      120



gatggcgagt ggacttacga tgacgcgact aaaactttca ccgttaccga aaagccggaa      180



gtaattgacg cttccgaact gaccccggca gtcacgactt acaaattggt cattaacggg      240



aaaaccctta aaggggaaac caccactaag gcggttgacg cggaaacggc cgagaaagcg      300



ttcaagcagt atgctaacga caatggtgtt gatggcgtgt ggacctatga tgatgctaca      360



aaaacattta cggtgaccga aggtggcggc ggttccgatg tcgacaataa gttcaataaa      420



gagcagcaga acgccttctg ggagattctc cacctcccga atctgaacga ggagcagcgt      480



aacggtttta ttcaatctct gaaagacgat ccgtcacaga gcgctaacct gctggcagaa      540



gcaaaaaaat taaatgatgc ccaggcgccg aaaggcggtg ggggatccac gcccgaaatg      600



cccgtgttgg agaaccgcgc tgcacagggt gatatcacgg ccccaggcgg tgcccgtcgc      660



ctcacgggag accaaaccgc agccttgcgt gacagccttt ccgataaacc tgcaaaaaac      720



attatcttgc ttattggcga cggtatgggc gattccgaaa ttacggccgc gcgcaattat      780



gccgaaggcg ctggtggctt cttcaagggg attgatgcgt taccactgac agggcagtac      840



actcactacg cgctcaacaa aaaaaccggt aagccagatt acgtaaccga ctctgctgcg      900



agcgccacag cctggtcaac tggtgtgaaa acttataacg gcgccttagg cgtcgacatt      960



cacgaaaaag atcacccgac gattctggaa atggcgaaag cggccggtct ggcgacggga     1020



aacgtgtcta cggcggaact ccaggacgcg acgcccgccg cactggtggc ccatgtgacc     1080



tctcgtaagt gctacggccc tagtgcgacc tcggagaaat gcccaggcaa tgctctggaa     1140



aaagggggca agggttctat tactgagcag ctgctgaatg cgcgcgctga tgtgacgctg     1200



ggtggcggag caaaaacctt tgccgaaacc gccactgccg gtgagtggca ggggaaaact     1260



ctgcgcgaac aggcgcaagc ccgcggatat caactggtgt ctgatgcggc gtcgctgaac     1320



tccgtaaccg aagcgaacca gcagaaaccg cttctgggtc tgttcgcaga tggcaatatg     1380



cctgtgcgtt ggctggggcc caaagcaacg tatcacggca acatcgataa gcctgctgta     1440



acgtgtacgc cgaacccgca gcgtaatgat agtgtaccga cactcgcgca gatgaccgat     1500



aaagcaatcg agctgctgtc gaagaacgaa aaaggttttt tcctgcaagt tgagggcgcg     1560



agcattgatc gtcagaacca tgccgctaac ccctgcggcc agatcgggga aacggttgat     1620



ctggatgagg ctgtacagcg tgctctggaa tttgcgaaaa aagagggtaa taccttagtg     1680



attgttaccg cagaccacgc acacgctagc cagatcgttg caccggacac taaggcaccg     1740



ggcctgaccc aggctctgaa caccaaggac ggggcggtta tggttatgtc ctatggtaac     1800



tcggaagagg actcccaaga acataccggt tcgcaattac gcatcgcggc gtatggtccg     1860



catgcagcga acgtagtggg tctgaccgat cagaccgatc tgttctatac aatgaaagcc     1920



gcgttgggac tcaaactgga gggatcccat catcatcacc atcacggtgg cggtggtagc     1980



atgcgccata aaggctcg                                                   1998





<210>  7

<211>  666

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  7



Ala Asp Thr Pro Glu Met Pro Val Leu Glu Asn Arg Ala Ala Gln Gly 

1               5                   10                  15      





Asp Ile Thr Ala Pro Gly Gly Ala Arg Arg Leu Thr Gly Asp Gln Thr 

            20                  25                  30          





Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys Pro Ala Lys Asn Ile Ile 

        35                  40                  45              





Leu Leu Ile Gly Asp Gly Met Gly Asp Ser Glu Ile Thr Ala Ala Arg 

    50                  55                  60                  





Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe Lys Gly Ile Asp Ala Leu 

65                  70                  75                  80  





Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala Leu Asn Lys Lys Thr Gly 

                85                  90                  95      





Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala Ser Ala Thr Ala Trp Ser 

            100                 105                 110         





Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu Gly Val Asp Ile His Glu 

        115                 120                 125             





Lys Asp His Pro Thr Ile Leu Glu Met Ala Lys Ala Ala Gly Leu Ala 

    130                 135                 140                 





Thr Gly Asn Val Ser Thr Ala Glu Leu Gln Asp Ala Thr Pro Ala Ala 

145                 150                 155                 160 





Leu Val Ala His Val Thr Ser Arg Lys Cys Tyr Gly Pro Ser Ala Thr 

                165                 170                 175     





Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu Lys Gly Gly Lys Gly Ser 

            180                 185                 190         





Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala Asp Val Thr Leu Gly Gly 

        195                 200                 205             





Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr Ala Gly Glu Trp Gln Gly 

    210                 215                 220                 





Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg Gly Tyr Gln Leu Val Ser 

225                 230                 235                 240 





Asp Ala Ala Ser Leu Asn Ser Val Thr Glu Ala Asn Gln Gln Lys Pro 

                245                 250                 255     





Leu Leu Gly Leu Phe Ala Asp Gly Asn Met Pro Val Arg Trp Leu Gly 

            260                 265                 270         





Pro Lys Ala Thr Tyr His Gly Asn Ile Asp Lys Pro Ala Val Thr Cys 

        275                 280                 285             





Thr Pro Asn Pro Gln Arg Asn Asp Ser Val Pro Thr Leu Ala Gln Met 

    290                 295                 300                 





Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys Asn Glu Lys Gly Phe Phe 

305                 310                 315                 320 





Leu Gln Val Glu Gly Ala Ser Ile Asp Arg Gln Asn His Ala Ala Asn 

                325                 330                 335     





Pro Cys Gly Gln Ile Gly Glu Thr Val Asp Leu Asp Glu Ala Val Gln 

            340                 345                 350         





Arg Ala Leu Glu Phe Ala Lys Lys Glu Gly Asn Thr Leu Val Ile Val 

        355                 360                 365             





Thr Ala Asp His Ala His Ala Ser Gln Ile Val Ala Pro Asp Thr Lys 

    370                 375                 380                 





Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr Lys Asp Gly Ala Val Met 

385                 390                 395                 400 





Val Met Ser Tyr Gly Asn Ser Glu Glu Asp Ser Gln Glu His Thr Gly 

                405                 410                 415     





Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro His Ala Ala Asn Val Val 

            420                 425                 430         





Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr Thr Met Lys Ala Ala Leu 

        435                 440                 445             





Gly Leu Lys Leu Glu Gly Gly Gly Gly Ser Asp Val Asp Asn Lys Phe 

    450                 455                 460                 





Asn Lys Glu Gln Gln Asn Ala Phe Trp Glu Ile Leu His Leu Pro Asn 

465                 470                 475                 480 





Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 

                485                 490                 495     





Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp 

            500                 505                 510         





Ala Gln Ala Pro Lys Gly Gly Gly Gly Ser Thr Tyr Lys Leu Val Ile 

        515                 520                 525             





Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala 

    530                 535                 540                 





Ala Thr Ala Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val 

545                 550                 555                 560 





Asp Gly Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr 

                565                 570                 575     





Glu Lys Pro Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr 

            580                 585                 590         





Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr 

        595                 600                 605             





Thr Lys Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr 

    610                 615                 620                 





Ala Asn Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr 

625                 630                 635                 640 





Lys Thr Phe Thr Val Thr Glu Gly Ser His His His His His His Gly 

                645                 650                 655     





Gly Gly Gly Ser Met Arg His Lys Gly Ser 

            660                 665     





<210>  8

<211>  1998

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  8

gcagatacgc ccgaaatgcc cgtgttggag aaccgcgctg cacagggtga tatcacggcc       60



ccaggcggtg cccgtcgcct cacgggagac caaaccgcag ccttgcgtga cagcctttcc      120



gataaacctg caaaaaacat tatcttgctt attggcgacg gtatgggcga ttccgaaatt      180



acggccgcgc gcaattatgc cgaaggcgct ggtggcttct tcaaggggat tgatgcgtta      240



ccactgacag ggcagtacac tcactacgcg ctcaacaaaa aaaccggtaa gccagattac      300



gtaaccgact ctgctgcgag cgccacagcc tggtcaactg gtgtgaaaac ttataacggc      360



gccttaggcg tcgacattca cgaaaaagat cacccgacga ttctggaaat ggcgaaagcg      420



gccggtctgg cgacgggaaa cgtgtctacg gcggaactcc aggacgcgac gcccgccgca      480



ctggtggccc atgtgacctc tcgtaagtgc tacggcccta gtgcgacctc ggagaaatgc      540



ccaggcaatg ctctggaaaa agggggcaag ggttctatta ctgagcagct gctgaatgcg      600



cgcgctgatg tgacgctggg tggcggagca aaaacctttg ccgaaaccgc cactgccggt      660



gagtggcagg ggaaaactct gcgcgaacag gcgcaagccc gcggatatca actggtgtct      720



gatgcggcgt cgctgaactc cgtaaccgaa gcgaaccagc agaaaccgct tctgggtctg      780



ttcgcagatg gcaatatgcc tgtgcgttgg ctggggccca aagcaacgta tcacggcaac      840



atcgataagc ctgctgtaac gtgtacgccg aacccgcagc gtaatgatag tgtaccgaca      900



ctcgcgcaga tgaccgataa agcaatcgag ctgctgtcga agaacgaaaa aggttttttc      960



ctgcaagttg agggcgcgag cattgatcgt cagaaccatg ccgctaaccc ctgcggccag     1020



atcggggaaa cggttgatct ggatgaggct gtacagcgtg ctctggaatt tgcgaaaaaa     1080



gagggtaata ccttagtgat tgttaccgca gaccacgcac acgctagcca gatcgttgca     1140



ccggacacta aggcaccggg cctgacccag gctctgaaca ccaaggacgg ggcggttatg     1200



gttatgtcct atggtaactc ggaagaggac tcccaagaac ataccggttc gcaattacgc     1260



atcgcggcgt atggtccgca tgcagcgaac gtagtgggtc tgaccgatca gaccgatctg     1320



ttctatacaa tgaaagccgc gttgggactc aaactggagg gcggtggggg atccgatgtc     1380



gacaataagt tcaataaaga gcagcagaac gccttctggg agattctcca cctcccgaat     1440



ctgaacgagg agcagcgtaa cggttttatt caatctctga aagacgatcc gtcacagagc     1500



gctaacctgc tggcagaagc aaaaaaatta aatgatgccc aggcgccgaa aggtggcggc     1560



ggttccacgt ataaactcgt catcaacggt aaaacgttaa aaggcgaaac taccactgaa     1620



gctgttgatg ctgctacggc agaaaaagtg ttcaaacagt acgcgaatga caatggcgtg     1680



gatggcgagt ggacttacga tgacgcgact aaaactttca ccgttaccga aaagccggaa     1740



gtaattgacg cttccgaact gaccccggca gtcacgactt acaaattggt cattaacggg     1800



aaaaccctta aaggggaaac caccactaag gcggttgacg cggaaacggc cgagaaagcg     1860



ttcaagcagt atgctaacga caatggtgtt gatggcgtgt ggacctatga tgatgctaca     1920



aaaacattta cggtgaccga aggatcccat catcatcacc atcacggtgg cggtggtagc     1980



atgcgccata aaggctcg                                                   1998





<210>  9

<211>  376

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  9

gaacaattat cttcaacatg gactaatctt gtccttgaat caagtactgt gatccgccca       60



cgtaccttct cagcttctcc ccaaactgtt agaactcgaa cgtcctatct tcttttgctt      120



ccaccagttg attgccaagt tcctctagtt caaactcatc ccgagttggc cgtttaggta      180



tatttgactt tgccaatgcc gcccctcctt attgaattga gtatcagtct tacaccgata      240



taaaaatcca tgaaaacatt ttacttacaa atagattaag gaaaattttt ctaatataaa      300



tgtttgaaat aatttaccta atttagtata atttgctttg ttgcaaaaat ataccaaaat      360



gagaggagct ttaata                                                      376





<210>  10

<211>  44

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  10

aaggcgccgc aacttttgat tcgctcaggc gtttaatagg atgt                        44





<210>  11

<211>  72

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  11

atgaaaacaa tacgaacagg catgatgact ttggcggcac tggccgtttt gggaaccaac       60



gtggtagcgg ct                                                           72





<210>  12

<211>  69

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  12

atgaaaaagg tcgttaacag tgtattggct agtgcactcg cacttactgt tgctcccatg       60



gctttcgct                                                               69





<210>  13

<211>  84

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  13

atgtcaattt cggtaagatt caagagttta attgctttac ttatgactgt agtattttta       60



ctagtaccaa gttccgcatt cgct                                              84





<210>  14

<211>  90

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Noriho Kamiya, Kyoichi Matsuba, Kenji Nagai, Kounosuke Hayashi,



<400>  14

atgaaaaaaa gaagggtcgt taacagtgta ttgcttctgc tactgctagc tagtgcactc       60



gcacttactg ttgctcccat ggctttcgct                                        90



