﻿               SEQUENCE LISTING

<110> INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) 
      INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (ID
      IBAPS) 

<120> Diagnostic Method for Detecting a GABA(A) Related Autoimmune Disease and Related Subject-Matter

<130> 103263PC

<160> 4

<170> BiSSAP 1.0

<210> 1
<211> 456
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..456
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                   15    
Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                   25                  30        
Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                   40                  45            
Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                   55                  60                
Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                   70                  75                  80
Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                   90                  95    
Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                  105                110        
Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                  120                125            
His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                  135                140                
Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                  150                155                  160
Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                  170                175    
Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                  185                190        
Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                  200                205            
Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                  215                220                
Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                  230                235                  240
Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                  250                255    
Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                  265                270        
Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                  280                285            
Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                  295                300                
Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                  310                315                  320
Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                  330                335    
Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                  345                350        
Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                  360                365            
Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                  375                380                
Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                  390                395                  400
Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                  410                415    
Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                  425                430        
Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                  440                445            
Leu Lys Ala Pro Thr Pro His Gln 
    450                  455    

<210> 2
<211> 473
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..473
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                   15    
Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                   25                  30        
Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                   40                  45            
Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                   55                  60                
Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                   70                  75                  80
Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                   90                  95    
Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                  105                110        
Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                  120                125            
Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                  135                140                
Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                  150                155                  160
Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                  170                175    
Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                  185                190        
Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                  200                205            
Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                  215                220                
Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                  230                235                  240
Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                  250                255    
Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                  265                270        
Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                  280                285            
Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                  295                300                
Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                  310                315                  320
Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                  330                335    
Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                  345                350        
Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                  360                365            
Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                  375                380                
Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                  390                395                  400
Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                  410                415    
Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                  425                430        
Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                  440                445            
Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                  455                460                
Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                  470            

<210> 3
<211> 1371
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1371
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 3
atgaggaaaa gtccaggtct gtctgactgt ctttgggcct ggatcctcct tctgagcaca      60

ctgactggaa gaagctatgg acagccgtca ttacaagatg aacttaaaga caataccact     120

gtcttcacca ggattttgga cagactccta gatggttatg acaatcgcct gagaccagga     180

ttgggagagc gtgtaaccga agtgaagact gatatcttcg tcaccagttt cggacccgtt     240

tcagaccatg atatggaata tacaatagat gtatttttcc gtcaaagctg gaaggatgaa     300

aggttaaaat ttaaaggacc tatgacagtc ctccggttaa ataacctaat ggcaagtaaa     360

atctggactc cggacacatt tttccacaat ggaaagaagt cagtggccca caacatgacc     420

atgcccaaca aactcctgcg gatcacagag gatggcacct tgctgtacac catgaggctg     480

acagtgagag ctgaatgtcc gatgcatttg gaggacttcc ctatggatgc ccatgcttgc     540

ccactaaaat ttggaagtta tgcttataca agagcagaag ttgtttatga atggaccaga     600

gagccagcac gctcagtggt tgtagcagaa gatggatcac gtctaaacca gtatgacctt     660

cttggacaaa cagtagactc tggaattgtc cagtcaagta caggagaata tgttgttatg     720

accactcatt tccacttgaa gagaaagatt ggctactttg ttattcaaac atacctgcca     780

tgcataatga cagtgattct ctcacaagtc tccttctggc tcaacagaga gtctgtacca     840

gcaagaactg tctttggagt aacaactgtg ctcaccatga caacattgag catcagtgcc     900

agaaactccc tccctaaggt ggcttatgca acagctatgg attggtttat tgccgtgtgc     960

tatgcctttg tgttctcagc tctgattgag tttgccacag taaactattt cactaagaga    1020

ggttatgcat gggatggcaa aagtgtggtt ccagaaaagc caaagaaagt aaaggatcct    1080

cttattaaga aaaacaacac ttacgctcca acagcaacca gctacacccc taatttggcc    1140

aggggcgacc cgggcttagc caccattgct aaaagtgcaa ccatagaacc taaagaggtc    1200

aagcccgaaa caaaaccacc agaacccaag aaaaccttta acagtgtcag caaaattgac    1260

cgactgtcaa gaatagcctt cccgctgcta tttggaatct ttaacttagt ctactgggct    1320

acgtatttaa acagagagcc tcagctaaaa gcccccacac cacatcaata g             1371


<210> 4
<211> 1422
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1422
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 4
atgtggggcc ttgcgggagg aaggcttttc ggcatcttct cggccccggt gctggtggct      60

gtggtgtgct gcgcccagag tgtgaacgat cccgggaaca tgtcctttgt gaaggagacg     120

gtggacaagc tgttgaaagg ctacgacatt cgcctaagac ccgacttcgg gggtcccccg     180

gtctgcgtgg ggatgaacat cgacatcgcc agcatcgaca tggtttccga agtcaacatg     240

gattatacct taaccatgta ttttcaacaa tattggagag ataaaaggct cgcctattct     300

gggatccctc tcaacctcac gcttgacaat cgagtggctg accagctatg ggtgcccgac     360

acatatttct taaatgacaa aaagtcattt gtgcatggag tgacagtgaa aaaccgcatg     420

atccgtcttc accctgatgg gacagtgctg tatgggctca gaatcaccac gacagcagca     480

tgcatgatgg acctcaggag ataccccctg gacgagcaga actgcactct ggaaattgaa     540

agctatggct acaccacgga tgacattgag ttttactggc gaggcgggga caaggctgtt     600

accggagtgg aaaggattga gctcccgcag ttctccatcg tggagcaccg tctggtctcg     660

aggaatgttg tcttcgccac aggtgcctat cctcgactgt cactgagctt tcggttgaag     720

aggaacattg gatacttcat tcttcagact tatatgccct ctatactgat aacgattctg     780

tcgtgggtgt ccttctggat caattatgat gcatctgctg ctagagttgc cctcgggatc     840

acaactgtgc tgacaatgac aaccatcaac acccaccttc gggagacctt gcccaaaatc     900

ccctatgtca aagccattga catgtacctt atgggctgct tcgtctttgt gttcctggcc     960

cttctggagt atgcctttgt caactacatt ttctttggaa gaggccctca aaggcagaag    1020

aagcttgcag aaaagacagc caaggcaaag aatgaccgtt caaagagcga aagcaaccgg    1080

gtggatgctc atggaaatat tctgttgaca tcgctggaag ttcacaatga aatgaatgag    1140

gtctcaggcg gcattggcga taccaggaat tcagcaatat cctttgacaa ctcaggaatc    1200

cagtacagga aacagagcat gcctcgagaa gggcatgggc gattcctggg ggacagaagc    1260

ctcccgcaca agaagaccca tctacggagg aggtcttcac agctcaaaat taaaatacct    1320

gatctaaccg atgtgaatgc catagacaga tggtccagga tcgtgtttcc attcactttt    1380

tctcttttca acttagttta ctggctgtac tatgttaact ga                       1422


<210> 5
<211> 475
<212> PRT
<213> Homo sapiens

<220> 
<221> source
<222> 1..475
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 5

Met Ser Ser Pro Asn Ile Trp Ser Thr Gly Ser Ser Val Tyr Ser Thr 
1               5                   10                  15      


Pro Val Phe Ser Gln Lys Met Thr Val Trp Ile Leu Leu Leu Leu Ser 
            20                  25                  30          


Leu Tyr Pro Gly Phe Thr Ser Gln Lys Ser Asp Asp Asp Tyr Glu Asp 
        35                  40                  45              


Tyr Ala Ser Asn Lys Thr Trp Val Leu Thr Pro Lys Val Pro Glu Gly 
    50                  55                  60                  


Asp Val Thr Val Ile Leu Asn Asn Leu Leu Glu Gly Tyr Asp Asn Lys 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Gly Val Lys Pro Thr Leu Ile His Thr Asp Met 
                85                  90                  95      


Tyr Val Asn Ser Ile Gly Pro Val Asn Ala Ile Asn Met Glu Tyr Thr 
            100                 105                 110         


Ile Asp Ile Phe Phe Ala Gln Thr Trp Tyr Asp Arg Arg Leu Lys Phe 
        115                 120                 125             


Asn Ser Thr Ile Lys Val Leu Arg Leu Asn Ser Asn Met Val Gly Lys 
    130                 135                 140                 


Ile Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser Lys Lys Ala Asp Ala 
145                 150                 155                 160 


His Trp Ile Thr Thr Pro Asn Arg Met Leu Arg Ile Trp Asn Asp Gly 
                165                 170                 175     


Arg Val Leu Tyr Thr Leu Arg Leu Thr Ile Asp Ala Glu Cys Gln Leu 
            180                 185                 190         


Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe 
        195                 200                 205             


Ser Ser Tyr Gly Tyr Pro Arg Glu Glu Ile Val Tyr Gln Trp Lys Arg 
    210                 215                 220                 


Ser Ser Val Glu Val Gly Asp Thr Arg Ser Trp Arg Leu Tyr Gln Phe 
225                 230                 235                 240 


Ser Phe Val Gly Leu Arg Asn Thr Thr Glu Val Val Lys Thr Thr Ser 
                245                 250                 255     


Gly Asp Tyr Val Val Met Ser Val Tyr Phe Asp Leu Ser Arg Arg Met 
            260                 265                 270         


Gly Tyr Phe Thr Ile Gln Thr Tyr Ile Pro Cys Thr Leu Ile Val Val 
        275                 280                 285             


Leu Ser Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg 
    290                 295                 300                 


Thr Ser Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr 
305                 310                 315                 320 


Ile Ala Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp 
                325                 330                 335     


Leu Phe Val Ser Val Cys Phe Ile Phe Val Phe Ser Ala Leu Val Glu 
            340                 345                 350         


Tyr Gly Thr Leu Arg Tyr Phe Val Ser Asn Arg Lys Pro Ser Lys Asp 
        355                 360                 365             


Lys Asp Lys Lys Lys Lys Asn Pro Leu Leu Arg Met Phe Ser Phe Lys 
    370                 375                 380                 


Ala Pro Thr Ile Asp Ile Arg Pro Arg Ser Ala Thr Ile Gln Met Asn 
385                 390                 395                 400 


Asn Ala Thr His Leu Gln Glu Arg Asp Glu Glu Tyr Gly Tyr Glu Cys 
                405                 410                 415     


Leu Asp Gly Lys Asp Cys Ala Ser Phe Phe Cys Cys Phe Glu Asp Cys 
            420                 425                 430         


Arg Thr Gly Ala Trp Arg His Gly Arg Ile His Ile Arg Ile Ala Lys 
        435                 440                 445             


Met Asp Ser Tyr Ala Arg Ile Phe Phe Pro Thr Ala Phe Cys Leu Phe 
    450                 455                 460                 


Asn Leu Val Tyr Trp Val Ser Tyr Leu Tyr Leu 
465                 470                 475 


<210> 6
<211> 1428
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1428
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 6
atgagttcgc caaatatatg gagcacagga agctcagtct actcgactcc tgtattttca       60

cagaaaatga cggtgtggat tctgctcctg ctgtcgctct accctggctt cactagccag      120

aaatctgatg atgactatga agattatgct tctaacaaaa catgggtctt gactccaaaa      180

gttcctgagg gtgatgtcac tgtcatctta aacaacctgc tggaaggata tgacaataaa      240

cttcggcctg atataggagt gaagccaacg ttaattcaca cagacatgta tgtgaatagc      300

attggtccag tgaacgctat caatatggaa tacactattg atatattttt tgcgcaaacg      360

tggtatgaca gacgtttgaa atttaacagc accattaaag tcctccgatt gaacagcaac      420

atggtgggga aaatctggat tccagacact ttcttcagaa attccaaaaa agctgatgca      480

cactggatca ccacccccaa caggatgctg agaatttgga atgatggtcg agtgctctac      540

accctaaggt tgacaattga tgctgagtgc caattacaat tgcacaactt tccaatggat      600

gaacactcct gccccttgga gttctcaagt tatggctatc cacgtgaaga aattgtttat      660

caatggaagc gaagttctgt tgaagtgggc gacacaagat cctggaggct ttatcaattc      720

tcatttgttg gtctaagaaa taccaccgaa gtagtgaaga caacttccgg agattatgtg      780

gtcatgtctg tctactttga tctgagcaga agaatgggat actttaccat ccagacctat      840

atcccctgca cactcattgt cgtcctatcc tgggtgtctt tctggatcaa taaggatgct      900

gttccagcca gaacatcttt aggtatcacc actgtcctga caatgaccac cctcagcacc      960

attgcccgga aatcgctccc caaggtctcc tatgtcacag cgatggatct ctttgtatct     1020

gtttgtttca tctttgtctt ctctgctctg gtggagtatg gcaccttgcg ttattttgtc     1080

agcaaccgga aaccaagcaa ggacaaagat aaaaagaaga aaaaccctct tcttcggatg     1140

ttttccttca aggcccctac cattgatatc cgcccaagat cagcaaccat tcaaatgaat     1200

aatgctacac accttcaaga gagagatgaa gagtacggct atgagtgtct ggacggcaag     1260

gactgtgcca gttttttctg ctgttttgaa gattgtcgaa caggagcttg gagacatggg     1320

aggatacata tccgcattgc caaaatggac tcctatgctc ggatcttctt ccccactgcc     1380

ttctgcctgt ttaatctggt ctattgggtc tcctacctct acctgtga                  1428


