                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Coagulation Factor VII Polypeptide

<130>  8719WO01

<140>  13188715.0
<141>  2013-10-15

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  406
<212>  PRT
<213>  Human

<400>  1

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  2
<211>  254
<212>  PRT
<213>  Human

<400>  2

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 
1               5                   10                  15      


Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 
            20                  25                  30          


Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn 
        35                  40                  45              


Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His 
    50                  55                  60                  


Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu 
                85                  90                  95      


His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
    130                 135                 140                 


Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln 
145                 150                 155                 160 


Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 
225                 230                 235                 240 


Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
                245                 250                 


<210>  3
<211>  254
<212>  PRT
<213>  Chimpanzee

<400>  3

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 
1               5                   10                  15      


Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 
            20                  25                  30          


Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn 
        35                  40                  45              


Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His 
    50                  55                  60                  


Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Tyr Ile Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu 
                85                  90                  95      


His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Ala Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
    130                 135                 140                 


Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln 
145                 150                 155                 160 


Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Ile Val Ser Trp Gly Gln Gly Cys Ala Ser Val Gly His Phe Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 
225                 230                 235                 240 


Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
                245                 250                 


<210>  4
<211>  254
<212>  PRT
<213>  Dog

<400>  4

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Ala Val Lys Val Asp Gly Lys Leu Leu Cys Gly Gly Thr Leu Ile Asp 
            20                  25                  30          


Ala Ala Trp Val Val Ser Ala Ala His Cys Phe Glu Arg Ile Lys Asn 
        35                  40                  45              


Trp Lys Asn Leu Thr Val Val Leu Gly Glu His Asp Leu Ser Glu Asp 
    50                  55                  60                  


Asp Gly Asp Glu Gln Glu Arg His Val Ala Arg Val Ile Val Pro Asp 
65                  70                  75                  80  


Lys Tyr Ile Pro Leu Lys Thr Asn His Asp Ile Ala Leu Leu His Leu 
                85                  90                  95      


Arg Thr Pro Val Ala Tyr Thr Asp His Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Lys Thr Phe Ser Glu Arg Thr Leu Ala Phe Ile Arg Phe Ser Ala 
        115                 120                 125             


Val Ser Gly Trp Gly Arg Leu Leu Asp Arg Gly Ala Lys Ala Arg Val 
    130                 135                 140                 


Leu Met Ala Ile Gln Val Pro Arg Leu Met Thr Gln Asp Cys Leu Glu 
145                 150                 155                 160 


Gln Ala Arg Arg Arg Pro Gly Ser Pro Ser Ile Thr Asp Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Leu Asp Gly Ser Lys Asp Ala Cys Gln Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr Lys Phe Gln Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Glu Gly His Phe Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Arg Gln Leu Met Val 
225                 230                 235                 240 


Ser Ser His Thr Leu Arg Gly Leu Leu Arg Ala Pro Leu Pro 
                245                 250                 


<210>  5
<211>  255
<212>  PRT
<213>  Porcine

<400>  5

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Met Leu Lys Leu Lys Gly Ala Leu Leu Cys Gly Gly Thr Leu Leu Asn 
            20                  25                  30          


Thr Ser Trp Val Val Ser Ala Ala His Cys Phe Asp Arg Ile Arg Ser 
        35                  40                  45              


Trp Lys Asp Leu Thr Val Val Leu Gly Glu His Asp Leu Ser Lys Asp 
    50                  55                  60                  


Glu Gly Asp Glu Gln Glu Arg Pro Val Ala Gln Val Phe Val Pro Asp 
65                  70                  75                  80  


Lys Tyr Val Pro Gly Lys Thr Asp His Asp Leu Ala Leu Val Arg Leu 
                85                  90                  95      


Ala Arg Pro Val Ala Leu Thr Asp His Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Ser Phe Ser Glu Arg Thr Leu Ala Phe Ile Arg Phe Ser Ala 
        115                 120                 125             


Val Ser Gly Trp Gly Arg Leu Leu Asp Arg Gly Ala Lys Ala Arg Val 
    130                 135                 140                 


Leu Met Ala Ile Gln Val Pro Arg Leu Met Thr Gln Asp Cys Leu Glu 
145                 150                 155                 160 


Gln Ala Arg Arg Arg Pro Gly Ser Pro Ser Ile Thr Asp Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Leu Asp Gly Ser Lys Asp Ala Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr Arg Phe Arg Gly Thr Trp Phe Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Thr Gly Arg Phe Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Arg Tyr Thr Ala Trp Leu Leu Gly Leu Met Ser 
225                 230                 235                 240 


Ala Pro Pro Pro Pro Ser Glu Gly Leu Leu Arg Ala Pro Leu Pro 
                245                 250                 255 


<210>  6
<211>  255
<212>  PRT
<213>  Bovine

<400>  6

Ile Val Gly Gly His Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Met Leu Lys Leu Asn Gly Ala Leu Leu Cys Gly Gly Thr Leu Val Gly 
            20                  25                  30          


Pro Ala Trp Val Val Ser Ala Ala His Cys Phe Glu Arg Leu Arg Ser 
        35                  40                  45              


Arg Gly Asn Leu Thr Ala Val Leu Gly Glu His Asp Leu Ser Arg Val 
    50                  55                  60                  


Glu Gly Pro Glu Gln Glu Arg Arg Val Ala Gln Ile Ile Val Pro Lys 
65                  70                  75                  80  


Gln Tyr Val Pro Gly Gln Thr Asp His Asp Val Ala Leu Leu Gln Leu 
                85                  90                  95      


Ala Gln Pro Val Ala Leu Gly Asp His Val Ala Pro Leu Cys Leu Pro 
            100                 105                 110         


Asp Pro Asp Phe Ala Asp Gln Thr Leu Ala Phe Val Arg Phe Ser Ala 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Glu Arg Gly Val Thr Ala Arg Lys 
    130                 135                 140                 


Leu Met Val Val Leu Val Pro Arg Leu Leu Thr Gln Asp Cys Leu Gln 
145                 150                 155                 160 


Gln Ser Arg Gln Arg Pro Gly Gly Pro Val Val Thr Asp Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ala Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr Arg Phe Arg Gly Thr Trp Phe Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Ala Gly His Phe Gly Ile 
    210                 215                 220                 


Tyr Thr Arg Val Ser Arg Tyr Thr Ala Trp Leu Arg Gln Leu Met Gly 
225                 230                 235                 240 


His Pro Pro Ser Arg Gln Gly Phe Phe Gln Val Pro Leu Leu Pro 
                245                 250                 255 


<210>  7
<211>  253
<212>  PRT
<213>  Mouse

<400>  7

Ile Val Gly Gly Asn Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Val Leu Lys Ile Asn Gly Leu Leu Leu Cys Gly Ala Val Leu Leu Asp 
            20                  25                  30          


Ala Arg Trp Ile Val Thr Ala Ala His Cys Phe Asp Asn Ile Arg Tyr 
        35                  40                  45              


Trp Gly Asn Ile Thr Val Val Met Gly Glu His Asp Phe Ser Glu Lys 
    50                  55                  60                  


Asp Gly Asp Glu Gln Val Arg Arg Val Thr Gln Val Ile Met Pro Asp 
65                  70                  75                  80  


Lys Tyr Ile Arg Gly Lys Ile Asn His Asp Ile Ala Leu Leu Arg Leu 
                85                  90                  95      


His Arg Pro Val Thr Phe Thr Asp Tyr Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Lys Ser Phe Ser Glu Asn Thr Leu Ala Arg Ile Arg Phe Ser Arg 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
    130                 135                 140                 


Leu Met Ser Ile Glu Val Pro Arg Leu Met Thr Gln Asp Cys Leu Glu 
145                 150                 155                 160 


His Ala Lys His Ser Ser Asn Thr Pro Lys Ile Thr Glu Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Met Asp Gly Thr Lys Asp Ala Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr His Tyr His Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Ile Gly His Ile Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Asp Trp Leu Val Arg His Met Asp 
225                 230                 235                 240 


Ser Lys Leu Gln Val Gly Val Phe Arg Leu Pro Leu Leu 
                245                 250             


<210>  8
<211>  253
<212>  PRT
<213>  Rat

<400>  8

Ile Val Gly Gly Tyr Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Val Leu Lys Phe Asn Glu Ala Leu Leu Cys Gly Ala Val Leu Leu Asp 
            20                  25                  30          


Thr Arg Trp Ile Val Thr Ala Ala His Cys Phe Asp Lys Phe Gly Lys 
        35                  40                  45              


Leu Val Asn Ile Thr Val Val Leu Gly Glu His Asp Phe Ser Glu Lys 
    50                  55                  60                  


Glu Gly Thr Glu Gln Val Arg Leu Val Glu Gln Val Ile Met Pro Asn 
65                  70                  75                  80  


Lys Tyr Thr Arg Gly Arg Thr Asp His Asp Ile Ala Leu Val Arg Leu 
                85                  90                  95      


His Arg Pro Val Thr Phe Thr Asp Tyr Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Ala Phe Ser Glu Asn Thr Leu Ala Ser Ile Arg Phe Ser Arg 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
    130                 135                 140                 


Leu Met Val Ile Glu Val Pro Arg Leu Met Thr Gln Asp Cys Leu Glu 
145                 150                 155                 160 


His Ala Lys His Ser Ala Asn Thr Pro Arg Ile Thr Glu Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Met Asp Gly Thr Lys Asp Ala Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr His Tyr His Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Ile Gly His Ile Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Asp Trp Leu Val Lys Tyr Met Asp 
225                 230                 235                 240 


Ser Lys Leu Arg Val Gly Ile Ser Arg Val Ser Leu Leu 
                245                 250             


<210>  9
<211>  253
<212>  PRT
<213>  Rabbit

<400>  9

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Met Asn Gly Ser Thr Leu Leu Cys Gly Gly Ser Leu Leu Asp 
            20                  25                  30          


Thr His Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Leu Ser Ser 
        35                  40                  45              


Leu Arg Asn Leu Thr Ile Val Leu Gly Glu His Asp Leu Ser Glu His 
    50                  55                  60                  


Glu Gly Asp Glu Gln Val Arg His Val Ala Gln Leu Ile Met Pro Asp 
65                  70                  75                  80  


Lys Tyr Val Pro Gly Lys Thr Asp His Asp Ile Ala Leu Leu Arg Leu 
                85                  90                  95      


Leu Gln Pro Ala Ala Leu Thr Asn Asn Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Asn Phe Ser Glu Ser Thr Leu Ala Thr Ile Arg Phe Ser Arg 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Tyr Arg Gly Ala Leu Ala Arg Glu 
    130                 135                 140                 


Leu Met Ala Ile Asp Val Pro Arg Leu Met Thr Gln Asp Cys Val Glu 
145                 150                 155                 160 


Gln Ser Glu His Lys Pro Gly Ser Pro Glu Val Thr Gly Asn Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Leu Asp Gly Ser Lys Asp Ala Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr Ser Tyr His Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Val Val Ser Trp Gly Glu Gly Cys Ala Ala Val Gly His Val Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Arg Tyr Thr Glu Trp Leu Ser Arg Leu Met Arg 
225                 230                 235                 240 


Ser Lys Leu His His Gly Ile Gln Arg His Pro Phe Pro 
                245                 250             


