                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  Chimeric antigen receptor

<130>  P103292PCT

<140>  PCT/GB2014/053058
<141>  2014-10-10

<150>  GB 1317929.6
<151>  2013-10-10

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-HCH2CH3pvaa-CD28OXZ

<400>  1

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
            20                  25                  30          


Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
        35                  40                  45              


Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
    50                  55                  60                  


Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
65                  70                  75                  80  


Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
                85                  90                  95      


Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
            100                 105                 110         


Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
        115                 120                 125             


Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
    130                 135                 140                 


Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
                165                 170                 175     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            180                 185                 190         


Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys 
        195                 200                 205             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    210                 215                 220                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
225                 230                 235                 240 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                245                 250                 255     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            260                 265                 270         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        275                 280                 285             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    290                 295                 300                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
305                 310                 315                 320 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                325                 330                 335     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            340                 345                 350         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        355                 360                 365             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    370                 375                 380                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp 
385                 390                 395                 400 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                405                 410                 415     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            420                 425                 430         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        435                 440                 445             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    450                 455                 460                 


Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
465                 470                 475                 480 


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                485                 490                 495     


Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            500                 505                 510         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        515                 520                 525             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    530                 535                 540                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
545                 550                 555                 560 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                565                 570                 575     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            580                 585                 590         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        595                 600                 605             


Gln Ala Leu Pro Pro Arg 
    610                 


<210>  2
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-CD8STK-CD28OXZ

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
            20                  25                  30          


Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
        35                  40                  45              


Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
    50                  55                  60                  


Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
65                  70                  75                  80  


Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
                85                  90                  95      


Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
            100                 105                 110         


Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
        115                 120                 125             


Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
    130                 135                 140                 


Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                165                 170                 175     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            180                 185                 190         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        195                 200                 205             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    210                 215                 220                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
225                 230                 235                 240 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                245                 250                 255     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            260                 265                 270         


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
        275                 280                 285             


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
    290                 295                 300                 


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
305                 310                 315                 320 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                325                 330                 335     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            340                 345                 350         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        355                 360                 365             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    370                 375                 380                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
385                 390                 395                 400 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                405                 410                 415     


His Met Gln Ala Leu Pro Pro Arg 
            420                 


<210>  3
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-HNG-CD28OXZ

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
            20                  25                  30          


Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
        35                  40                  45              


Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
    50                  55                  60                  


Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
65                  70                  75                  80  


Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
                85                  90                  95      


Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
            100                 105                 110         


Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
        115                 120                 125             


Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
    130                 135                 140                 


Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
                165                 170                 175     


Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
            180                 185                 190         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        195                 200                 205             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    210                 215                 220                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
225                 230                 235                 240 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro 
                245                 250                 255     


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
            260                 265                 270         


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val 
        275                 280                 285             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    290                 295                 300                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
305                 310                 315                 320 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                325                 330                 335     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            340                 345                 350         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        355                 360                 365             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    370                 375                 380                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395             


<210>  4
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-HCH2CH3pvaa-CD28OXZ

<400>  4

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            20                  25                  30          


Ser Thr Ser Gly Gly Gly Gly Ser Val Leu His Leu Val Pro Ile Asn 
        35                  40                  45              


Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 
    50                  55                  60                  


Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 
65                  70                  75                  80  


Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 
                85                  90                  95      


Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly 
            100                 105                 110         


Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro 
        115                 120                 125             


Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His 
    130                 135                 140                 


Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 
145                 150                 155                 160 


Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly 
                165                 170                 175     


Gly Gly Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr 
            180                 185                 190         


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        195                 200                 205             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu 
    210                 215                 220                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
225                 230                 235                 240 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                245                 250                 255     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            260                 265                 270         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        275                 280                 285             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    290                 295                 300                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
305                 310                 315                 320 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                325                 330                 335     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            340                 345                 350         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        355                 360                 365             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    370                 375                 380                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
385                 390                 395                 400 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro 
                405                 410                 415     


Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            420                 425                 430         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        435                 440                 445             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    450                 455                 460                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
465                 470                 475                 480 


Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
                485                 490                 495     


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
            500                 505                 510         


Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser 
        515                 520                 525             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    530                 535                 540                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
545                 550                 555                 560 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                565                 570                 575     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            580                 585                 590         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        595                 600                 605             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    610                 615                 620                 


Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630             


<210>  5
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-CD8STK-CD28OXZ

<400>  5

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            20                  25                  30          


Ser Thr Ser Gly Gly Gly Gly Ser Val Leu His Leu Val Pro Ile Asn 
        35                  40                  45              


Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 
    50                  55                  60                  


Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 
65                  70                  75                  80  


Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 
                85                  90                  95      


Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly 
            100                 105                 110         


Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro 
        115                 120                 125             


Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His 
    130                 135                 140                 


Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 
145                 150                 155                 160 


Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly 
                165                 170                 175     


Gly Gly Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            180                 185                 190         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        195                 200                 205             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    210                 215                 220                 


Cys Asp Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
225                 230                 235                 240 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                245                 250                 255     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            260                 265                 270         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        275                 280                 285             


Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    290                 295                 300                 


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
305                 310                 315                 320 


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    370                 375                 380                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440             


<210>  6
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor (CAR) dAPRIL-HNG-CD28OXZ

<400>  6

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            20                  25                  30          


Ser Thr Ser Gly Gly Gly Gly Ser Val Leu His Leu Val Pro Ile Asn 
        35                  40                  45              


Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 
    50                  55                  60                  


Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 
65                  70                  75                  80  


Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 
                85                  90                  95      


Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly 
            100                 105                 110         


Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro 
        115                 120                 125             


Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His 
    130                 135                 140                 


Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 
145                 150                 155                 160 


Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly 
                165                 170                 175     


Gly Gly Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr 
            180                 185                 190         


Cys Pro Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val 
        195                 200                 205             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    210                 215                 220                 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
225                 230                 235                 240 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                245                 250                 255     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln 
            260                 265                 270         


Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg 
        275                 280                 285             


Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys 
    290                 295                 300                 


Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
305                 310                 315                 320 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                325                 330                 335     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            340                 345                 350         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        355                 360                 365             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    370                 375                 380                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
385                 390                 395                 400 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                405                 410                 415     


Arg 
    


<210>  7
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane and intracellular T-cell signalling domain 
       (endodomain)

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
65                  70                  75                  80  


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                85                  90                  95      


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
            100                 105                 110         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        115                 120                 125             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    130                 135                 140                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
145                 150                 155                 160 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                165                 170                 175     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            180                 185                 190         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        195                 200                 205             


His Met Gln Ala Leu Pro Pro Arg 
    210                 215     


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  8

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  10
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (hinge-CH2CH3 of human IgG1)

<400>  10

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  11
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (human CD8 stalk)

<400>  11

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (human IgG1 hinge)

<400>  12

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  13
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  14
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp 
1               5                   10                  15      


Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu 
            20                  25                  30          


Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu 
        35                  40                  45              


Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln 
    50                  55                  60                  


Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys 
65                  70                  75                  80  


Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr 
                85                  90                  95      


Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile 
            100                 105                 110         


Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe 
        115                 120                 125             


Leu Gly Phe Val Lys Leu 
    130                 


<210>  15
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR 
       (dAPRIL-HCH2CH3pvaa-CD28OXZ)

<400>  15
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

agcgtgctcc acctggtgcc catcaacgcc accagcaagg acgactctga tgtgaccgag      120

gtgatgtggc agccagccct gagacggggc agaggcctgc aggcccaggg ctacggcgtg      180

agaatccagg acgctggcgt gtacctgctg tactcccagg tgctgttcca ggacgtgacc      240

ttcacaatgg gccaggtggt gagccgggag ggccagggca gacaggagac cctgttccgg      300

tgcatccgga gcatgcccag ccaccccgac agagcctaca acagctgcta cagcgctggc      360

gtgtttcacc tgcaccaggg cgacatcctg agcgtgatca tccccagagc cagagccaag      420

ctgaacctgt ccccccacgg cacctttctg ggcttcgtga agctgtctgg aggcggctcg      480

gatcccgccg agcccaaatc tcctgacaaa actcacacat gcccaccgtg cccagcacct      540

cccgtggccg gcccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      600

gcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      660

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      720

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      780

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      840

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      900

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      960

cccagcgaca tcgccgtgga gtgggagagc aatgggcaac cggagaacaa ctacaagacc     1020

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1080

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1140

aaccactaca cgcagaagag cctctccctg tctccgggta aaaaagatcc caaattttgg     1200

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1260

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1320

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1380

ttcgcagcct atcgctccag ggaccagagg ctgccccccg atgcccacaa gccccctggg     1440

ggaggcagtt tccggacccc catccaagag gagcaggccg acgcccactc caccctggcc     1500

aagatcagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1560

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1620

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1680

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1740

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1800

gacacctacg acgcccttca catgcaggcc ctgcctcctc gctaa                     1845


<210>  16
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR (dAPRIL-CD8STK-CD28OXZ)

<400>  16
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

agcgtgctcc acctggtgcc catcaacgcc accagcaagg acgactctga tgtgaccgag      120

gtgatgtggc agccagccct gagacggggc agaggcctgc aggcccaggg ctacggcgtg      180

agaatccagg acgctggcgt gtacctgctg tactcccagg tgctgttcca ggacgtgacc      240

ttcacaatgg gccaggtggt gagccgggag ggccagggca gacaggagac cctgttccgg      300

tgcatccgga gcatgcccag ccaccccgac agagcctaca acagctgcta cagcgctggc      360

gtgtttcacc tgcaccaggg cgacatcctg agcgtgatca tccccagagc cagagccaag      420

ctgaacctgt ccccccacgg cacctttctg ggcttcgtga agctgtctgg aggcggctcg      480

gatcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      540

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      600

gggctggact tcgcctgtga tatcttttgg gtgctggtgg tggttggtgg agtcctggct      660

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc      720

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag      780

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag ggaccagagg      840

ctgccccccg atgcccacaa gccccctggg ggaggcagtt tccggacccc catccaagag      900

gagcaggccg acgcccactc caccctggcc aagatcagag tgaagttcag caggagcgca      960

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1020

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1080

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1140

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1200

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1260

ctgcctcctc gctaa                                                      1275


<210>  17
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR (dAPRIL-HNG-CD28OXZ)

<400>  17
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

agcgtgctcc acctggtgcc catcaacgcc accagcaagg acgactctga tgtgaccgag      120

gtgatgtggc agccagccct gagacggggc agaggcctgc aggcccaggg ctacggcgtg      180

agaatccagg acgctggcgt gtacctgctg tactcccagg tgctgttcca ggacgtgacc      240

ttcacaatgg gccaggtggt gagccgggag ggccagggca gacaggagac cctgttccgg      300

tgcatccgga gcatgcccag ccaccccgac agagcctaca acagctgcta cagcgctggc      360

gtgtttcacc tgcaccaggg cgacatcctg agcgtgatca tccccagagc cagagccaag      420

ctgaacctgt ccccccacgg cacctttctg ggcttcgtga agctgtctgg aggcggctcg      480

gatcccgccg agcccaaatc tcctgacaaa actcacacat gcccaccgtg cccaaaagat      540

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      600

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      660

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      720

ccaccacgcg acttcgcagc ctatcgctcc agggaccaga ggctgccccc cgatgcccac      780

aagccccctg ggggaggcag tttccggacc cccatccaag aggagcaggc cgacgcccac      840

tccaccctgg ccaagatcag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      900

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      960

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1020

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1080

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1140

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgcctcc tcgctaa        1197


<210>  18
<211>  1902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR 
       (dAPRIL-HCH2CH3pvaa-CD28OXZ)

<400>  18
atgggcacct ccctgctgtg ctggatggcc ctgtgcctgc tgggagccga ccacgccgac       60

ggcaagccca ttcccaaccc cctgctgggc ctggactcca cctctggcgg aggcggcagc      120

gtgctgcacc tggtgcccat caacgccacc agcaaggacg actctgatgt gaccgaggtg      180

atgtggcagc cagccctgag acggggcaga ggcctgcagg cccagggcta cggcgtgaga      240

atccaggacg ctggcgtgta cctgctgtac tcccaggtgc tgttccagga cgtgaccttc      300

acaatgggcc aggtggtgag ccgggagggc cagggcagac aggagaccct gttccggtgc      360

atccggagca tgcccagcca ccccgacaga gcctacaaca gctgctacag cgctggcgtg      420

tttcacctgc accagggcga catcctgagc gtgatcatcc ccagagccag agccaagctg      480

aacctgtccc cccacggcac ctttctgggc ttcgtgaagc tgtctggagg cggctcggat      540

cccgccgagc ccaaatctcc tgacaaaact cacacatgcc caccgtgccc agcacctccc      600

gtggccggcc cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatcgcc      660

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      720

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      780

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      840

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      900

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      960

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1020

agcgacatcg ccgtggagtg ggagagcaat gggcaaccgg agaacaacta caagaccacg     1080

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1140

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1200

cactacacgc agaagagcct ctccctgtct ccgggtaaaa aagatcccaa attttgggtg     1260

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     1320

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     1380

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     1440

gcagcctatc gctccaggga ccagaggctg ccccccgatg cccacaagcc ccctggggga     1500

ggcagtttcc ggacccccat ccaagaggag caggccgacg cccactccac cctggccaag     1560

atcagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1620

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1680

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1740

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1800

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1860

acctacgacg cccttcacat gcaggccctg cctcctcgct aa                        1902


<210>  19
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR (dAPRIL-CD8STK-CD28OXZ)

<400>  19
atgggcacct ccctgctgtg ctggatggcc ctgtgcctgc tgggagccga ccacgccgac       60

ggcaagccca ttcccaaccc cctgctgggc ctggactcca cctctggcgg aggcggcagc      120

gtgctgcacc tggtgcccat caacgccacc agcaaggacg actctgatgt gaccgaggtg      180

atgtggcagc cagccctgag acggggcaga ggcctgcagg cccagggcta cggcgtgaga      240

atccaggacg ctggcgtgta cctgctgtac tcccaggtgc tgttccagga cgtgaccttc      300

acaatgggcc aggtggtgag ccgggagggc cagggcagac aggagaccct gttccggtgc      360

atccggagca tgcccagcca ccccgacaga gcctacaaca gctgctacag cgctggcgtg      420

tttcacctgc accagggcga catcctgagc gtgatcatcc ccagagccag agccaagctg      480

aacctgtccc cccacggcac ctttctgggc ttcgtgaagc tgtctggagg cggctcggat      540

cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      600

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      660

ctggacttcg cctgtgatat cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      720

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      780

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      840

taccagccct atgccccacc acgcgacttc gcagcctatc gctccaggga ccagaggctg      900

ccccccgatg cccacaagcc ccctggggga ggcagtttcc ggacccccat ccaagaggag      960

caggccgacg cccactccac cctggccaag atcagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1200

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1260

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1320

cctcctcgct aa                                                         1332


<210>  20
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequences coding for a CAR (dAPRIL-HNG-CD28OXZ)

<400>  20
atgggcacct ccctgctgtg ctggatggcc ctgtgcctgc tgggagccga ccacgccgac       60

ggcaagccca ttcccaaccc cctgctgggc ctggactcca cctctggcgg aggcggcagc      120

gtgctgcacc tggtgcccat caacgccacc agcaaggacg actctgatgt gaccgaggtg      180

atgtggcagc cagccctgag acggggcaga ggcctgcagg cccagggcta cggcgtgaga      240

atccaggacg ctggcgtgta cctgctgtac tcccaggtgc tgttccagga cgtgaccttc      300

acaatgggcc aggtggtgag ccgggagggc cagggcagac aggagaccct gttccggtgc      360

atccggagca tgcccagcca ccccgacaga gcctacaaca gctgctacag cgctggcgtg      420

tttcacctgc accagggcga catcctgagc gtgatcatcc ccagagccag agccaagctg      480

aacctgtccc cccacggcac ctttctgggc ttcgtgaagc tgtctggagg cggctcggat      540

cccgccgagc ccaaatctcc tgacaaaact cacacatgcc caccgtgccc aaaagatccc      600

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca      660

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac      720

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca      780

ccacgcgact tcgcagccta tcgctccagg gaccagaggc tgccccccga tgcccacaag      840

ccccctgggg gaggcagttt ccggaccccc atccaagagg agcaggccga cgcccactcc      900

accctggcca agatcagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag      960

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1020

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1080

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1140

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1200

gccaccaagg acacctacga cgcccttcac atgcaggccc tgcctcctcg ctaa           1254


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  21

Lys Gln Lys Lys Gln Lys 
1               5       


