                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  Molecule

<130>  P103142PCT

<140>  PCT/GB2014/053056
<141>  2014-10-10

<150>  GB 1317928.8
<151>  2013-10-10

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  2
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp 
1               5                   10                  15      


Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu 
            20                  25                  30          


Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu 
        35                  40                  45              


Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln 
    50                  55                  60                  


Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys 
65                  70                  75                  80  


Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr 
                85                  90                  95      


Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile 
            100                 105                 110         


Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe 
        115                 120                 125             


Leu Gly Phe Val Lys Leu 
    130                 


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR1

<400>  3

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR2

<400>  4

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR3

<400>  5

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1

<400>  6

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2

<400>  7

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3

<400>  8

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  9
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  10
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of bi-specific molecule

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Asn Arg Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Lys Asp Pro Lys Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
    290                 295                 300                 


Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
305                 310                 315                 320 


Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
                325                 330                 335     


Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
            340                 345                 350         


Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
        355                 360                 365             


Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
    370                 375                 380                 


Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
385                 390                 395                 400 


Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
                405                 410                 415     


Gly Thr Phe Leu Gly Phe Val Lys Leu 
            420                 425 


<210>  11
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of bi-specific molecule

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Asn Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ser Gly Gly Gly Gly Ser Val Leu His Leu 
305                 310                 315                 320 


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
                325                 330                 335     


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
            340                 345                 350         


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
        355                 360                 365             


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
    370                 375                 380                 


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
385                 390                 395                 400 


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
                405                 410                 415     


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
            420                 425                 430         


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
        435                 440                 445             


Lys Leu 
    450 


<210>  12
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of bi-specific molecule

<400>  12

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
            20                  25                  30          


Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
        35                  40                  45              


Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
    50                  55                  60                  


Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
65                  70                  75                  80  


Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
                85                  90                  95      


Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
            100                 105                 110         


Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
        115                 120                 125             


Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
    130                 135                 140                 


Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                165                 170                 175     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            180                 185                 190         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
    210                 215                 220                 


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
225                 230                 235                 240 


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
                245                 250                 255     


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
            260                 265                 270         


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
        275                 280                 285             


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
    290                 295                 300                 


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
305                 310                 315                 320 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu 
            340                 345                 350         


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
        355                 360                 365             


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
    370                 375                 380                 


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
385                 390                 395                 400 


Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr 
                405                 410                 415     


Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr 
            420                 425                 430         


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly 
        435                 440                 445             


Thr Lys Leu Glu Ile Asn Arg Ser 
    450                 455     


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  14

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence (IgG1 hinge)

<400>  15

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  16
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence (CD8 stalk)

<400>  16

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chain break linker motif

<400>  17

Ser Gly Gly Gly Ser Asp Pro 
1               5           


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serine-glycine linker

<400>  18

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  19
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence coding for a bi-specific molecule

<400>  19
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

caggtgcagc tgcagcagag cggagccgag ctggccagac caggcgccag cgtgaagatg      120

agctgcaagg ccagcggcta caccttcacc cggtacacca tgcactgggt gaagcagcgg      180

ccaggccagg gcctggagtg gatcggctac atcaacccca gcagaggcta caccaactac      240

aaccagaagt tcaaggacaa ggccaccctg accaccgaca agagcagcag caccgcctac      300

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cagatactac      360

gacgaccact actgcctgga ctactggggc cagggcacca ccctgaccgt gagcagctct      420

ggcggaggcg gctctggcgg aggcggctct ggcggaggcg gcagccagat cgtgctgacc      480

cagagcccag ccatcatgag cgccagccca ggcgagaagg tgaccatgac ctgcagcgcc      540

agcagcagcg tgagctacat gaactggtac cagcagaaga gcggcaccag ccccaagcgg      600

tggatctacg acaccagcaa gctggccagc ggcgtgccag cccacttcag aggcagcggc      660

agcggcacca gctacagcct gaccatcagc ggcatggagg ccgaggatgc cgccacctac      720

tactgccagc agtggagcag caaccccttc accttcggca gcggcaccaa gctggagatc      780

aaccggtcgg atcccgccga gcccaaatct cctgacaaaa ctcacacatg cccaccgtgc      840

ccaaaagatc ccaaatctgg cggaggcggc agcgtgctgc acctggtgcc catcaacgcc      900

accagcaagg acgactctga tgtgaccgag gtgatgtggc agccagccct gagacggggc      960

agaggcctgc aggcccaggg ctacggcgtg agaatccagg acgctggcgt gtacctgctg     1020

tactcccagg tgctgttcca ggacgtgacc ttcacaatgg gccaggtggt gagccgggag     1080

ggccagggca gacaggagac cctgttccgg tgcatccgga gcatgcccag ccaccccgac     1140

agagcctaca acagctgcta cagcgctggc gtgtttcacc tgcaccaggg cgacatcctg     1200

agcgtgatca tccccagagc cagagccaag ctgaacctgt ccccccacgg cacctttctg     1260

ggcttcgtga agctgtga                                                   1278


<210>  20
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence coding for a bi-specific molecule

<400>  20
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

caggtgcagc tgcagcagag cggagccgag ctggccagac caggcgccag cgtgaagatg      120

agctgcaagg ccagcggcta caccttcacc cggtacacca tgcactgggt gaagcagcgg      180

ccaggccagg gcctggagtg gatcggctac atcaacccca gcagaggcta caccaactac      240

aaccagaagt tcaaggacaa ggccaccctg accaccgaca agagcagcag caccgcctac      300

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cagatactac      360

gacgaccact actgcctgga ctactggggc cagggcacca ccctgaccgt gagcagctct      420

ggcggaggcg gctctggcgg aggcggctct ggcggaggcg gcagccagat cgtgctgacc      480

cagagcccag ccatcatgag cgccagccca ggcgagaagg tgaccatgac ctgcagcgcc      540

agcagcagcg tgagctacat gaactggtac cagcagaaga gcggcaccag ccccaagcgg      600

tggatctacg acaccagcaa gctggccagc ggcgtgccag cccacttcag aggcagcggc      660

agcggcacca gctacagcct gaccatcagc ggcatggagg ccgaggatgc cgccacctac      720

tactgccagc agtggagcag caaccccttc accttcggca gcggcaccaa gctggagatc      780

aaccggtcgg atcccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat tctggcggag gcggcagcgt gctgcacctg      960

gtgcccatca acgccaccag caaggacgac tctgatgtga ccgaggtgat gtggcagcca     1020

gccctgagac ggggcagagg cctgcaggcc cagggctacg gcgtgagaat ccaggacgct     1080

ggcgtgtacc tgctgtactc ccaggtgctg ttccaggacg tgaccttcac aatgggccag     1140

gtggtgagcc gggagggcca gggcagacag gagaccctgt tccggtgcat ccggagcatg     1200

cccagccacc ccgacagagc ctacaacagc tgctacagcg ctggcgtgtt tcacctgcac     1260

cagggcgaca tcctgagcgt gatcatcccc agagccagag ccaagctgaa cctgtccccc     1320

cacggcacct ttctgggctt cgtgaagctg tga                                  1353


<210>  21
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence coding for a bi-specific molecule

<400>  21
atgggcacct ccctgctgtg ctggatggcc ctgtgcctgc tgggagccga ccacgccgac       60

ggcgtgctgc acctggtgcc catcaacgcc accagcaagg acgactctga tgtgaccgag      120

gtgatgtggc agccagccct gagacggggc agaggcctgc aggcccaggg ctacggcgtg      180

agaatccagg acgctggcgt gtacctgctg tactcccagg tgctgttcca ggacgtgacc      240

ttcacaatgg gccaggtggt gagccgggag ggccagggca gacaggagac cctgttccgg      300

tgcatccgga gcatgcccag ccaccccgac agagcctaca acagctgcta cagcgctggc      360

gtgtttcacc tgcaccaggg cgacatcctg agcgtgatca tccccagagc cagagccaag      420

ctgaacctgt ccccccacgg cacctttctg ggcttcgtga agctgtctgg aggcggctcg      480

gatcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      540

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      600

gggctggact tcgcctgtga tagcggtggc ggtggcagcc aggtgcagct gcagcagagc      660

ggagccgagc tggccagacc aggcgccagc gtgaagatga gctgcaaggc cagcggctac      720

accttcaccc ggtacaccat gcactgggtg aagcagcggc caggccaggg cctggagtgg      780

atcggctaca tcaaccccag cagaggctac accaactaca accagaagtt caaggacaag      840

gccaccctga ccaccgacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc      900

agcgaggaca gcgccgtgta ctactgcgcc agatactacg acgaccacta ctgcctggac      960

tactggggcc agggcaccac cctgaccgtg agcagctctg gcggaggcgg ctctggcgga     1020

ggcggctctg gcggaggcgg cagccagatc gtgctgaccc agagcccagc catcatgagc     1080

gccagcccag gcgagaaggt gaccatgacc tgcagcgcca gcagcagcgt gagctacatg     1140

aactggtacc agcagaagag cggcaccagc cccaagcggt ggatctacga caccagcaag     1200

ctggccagcg gcgtgccagc ccacttcaga ggcagcggca gcggcaccag ctacagcctg     1260

accatcagcg gcatggaggc cgaggatgcc gccacctact actgccagca gtggagcagc     1320

aaccccttca ccttcggcag cggcaccaag ctggagatca accggtcgtg a              1371


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  22

Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Gln Lys Lys Gln Lys 
1               5       


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Gly Gly Gly Gly Ser 
1               5   


