                         SEQUENCE LISTING

<110>  Beth Israel Deaconess Medical Center, Inc.
 
<120>  STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) CLADE C ENVELOPE 
       (ENV) TRIMER VACCINES AND METHODS OF USING SAME

<130>  01948-235WO2

<150>  US 61/886,932
<151>  2013-10-04

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Val Thr Ser Ser Ala Ala Asn Val Thr Ser Asn Val 
    130                 135                 140                 


Thr Asn Asp Ala Asn Asn Ala Ser Asn Ala Asn Gly Arg Asn Val Ile 
145                 150                 155                 160 


Asn Glu Asp Met Gln Asn Cys Ser Phe Asn Ala Thr Thr Glu Ile Arg 
                165                 170                 175     


Asp Arg Lys Lys Glu Met Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val 
            180                 185                 190         


Pro Leu Asp Gly Glu Lys Ser Asp Asn Arg Tyr Arg Leu Ile Asn Cys 
        195                 200                 205             


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro 
    210                 215                 220                 


Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys 
225                 230                 235                 240 


Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr 
                245                 250                 255     


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
            260                 265                 270         


Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg Ser Glu Asn 
        275                 280                 285             


Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val 
    290                 295                 300                 


Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Thr Phe Tyr Ala Asn Asn Asp Ile Ile Gly Asp 
                325                 330                 335     


Ile Arg Gln Ala His Cys Asn Ile Ser Glu Glu Lys Trp Asn Asn Thr 
            340                 345                 350         


Leu His Arg Val Trp Lys Lys Leu Val Glu His Phe Pro Asn Lys Thr 
        355                 360                 365             


Thr Ile Arg Phe Asp Arg His Ser Gly Gly Asp Leu Glu Ile Thr Thr 
    370                 375                 380                 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
385                 390                 395                 400 


Leu Phe Asn Ile Thr Tyr Asn Ser Asn Tyr Thr Tyr Asn Asp Thr Lys 
                405                 410                 415     


His Asn Gly Thr Lys Val Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
            420                 425                 430         


Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile 
        435                 440                 445             


Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly Leu Leu Leu Thr 
    450                 455                 460                 


Arg Asp Gly Gly Asn Asn Ser Thr Glu Thr Glu Thr Phe Arg Pro Gly 
465                 470                 475                 480 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
                485                 490                 495     


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Arg 
            500                 505                 510         


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile 
            580                 585                 590         


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser 
        595                 600                 605             


Ala Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Glu Thr Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp 
625                 630                 635                 640 


Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Asn Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Lys Trp Asn Ser Leu Trp Asp Trp Phe Gly Ile Ser Asn Trp Leu 
        675                 680                 685             


Trp Tyr Ile Arg Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile 
    690                 695                 700                 


Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu 
705                 710                 715                 720 


Trp Val Leu Leu Ser Thr Phe Leu 
                725             


<210>  2
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Val Gly Asn 
            20                  25                  30          


Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Glu Ala Lys 
        35                  40                  45              


Ala Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Ile Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Ile Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Thr Cys Lys Asn Ile Thr Asn Asn Val Thr Asn Ile Phe Asn Ser Ser 
    130                 135                 140                 


Glu Gly Ile Asn Met Lys Glu Glu Ile Lys Asn Cys Ser Phe Asn Thr 
145                 150                 155                 160 


Thr Thr Glu Ile Arg Asp Lys Glu Lys Lys Glu Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Lys Pro Asp Ile Val Gln Leu Gly Glu Arg Asn Ser Ser Arg Tyr Ile 
            180                 185                 190         


Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Ser 
225                 230                 235                 240 


Asn Ile Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ser Glu Gly Glu Ile Met Ile 
            260                 265                 270         


Arg Ser Glu Asn Leu Thr Asp Asn Thr Lys Thr Ile Ile Val His Leu 
        275                 280                 285             


Asn Glu Ser Val Glu Ile Val Cys Ile Arg Pro Gly Asn Asn Thr Arg 
    290                 295                 300                 


Lys Gly Ile Arg Ile Gly Pro Gly Gln Val Phe Tyr Ala Thr Gly Asp 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Lys Trp 
                325                 330                 335     


Asn Thr Thr Leu Glu Lys Val Lys Lys Lys Leu Lys Glu His Phe Pro 
            340                 345                 350         


Asn Lys Thr Ile Asn Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Thr Lys Leu Phe Thr Asn Thr Thr Thr Asn Thr Thr Ile Leu Ile Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Phe Val Asn Met Trp Gln Glu Val Gly Arg Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Asn Ser Ser Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Val Arg Asp Gly Gly Ile Ser Asn Asp Thr Asn 
        435                 440                 445             


Asn Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
    450                 455                 460                 


Trp Arg Ser Glu Leu Tyr Ser Tyr Lys Val Val Glu Leu Lys Pro Leu 
465                 470                 475                 480 


Gly Val Ala Pro Thr Gly Ala Lys Arg Arg Val Val Glu Met Glu Arg 
                485                 490                 495     


Ser Lys Arg Ala Val Gly Ile Gly Ala Ala Leu Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Ala Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Ile Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Lys Glu 
        595                 600                 605             


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Val Ser 
    610                 615                 620                 


Asn Tyr Thr Glu Thr Ile Tyr Arg Leu Leu Glu Glu Ser Gln Thr Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Lys Glu Leu Leu Glu Leu Ser Lys Trp Asp Ser 
                645                 650                 655     


Leu Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Thr Lys Ser 
            660                 665                 670         


Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro Glu Ala Pro Arg 
        675                 680                 685             


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
    690                 695                 700                 


Thr Phe Leu 
705         


<210>  3
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Met Gly Asn 
            20                  25                  30          


Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Val Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Ile Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Cys Ser Thr Phe Asn Cys Ser Asn Asn Ala Gly Thr Ile Glu 
    130                 135                 140                 


Glu Gln Glu Leu Lys Asn Cys Ser Phe Asn Ala Thr Thr Val Val Arg 
145                 150                 155                 160 


Asp Lys Lys Gln Thr Val Ser Ala Leu Phe Tyr Lys Leu Asp Val Val 
                165                 170                 175     


Pro Leu Gly Gly Asp Asn Asn Asn Asn Asn Lys Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Lys Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val His Leu Asn Asp 
        275                 280                 285             


Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Asn Ile Asn Lys Asp Lys Trp Asn 
                325                 330                 335     


Lys Thr Leu Gln Gln Val Gly Lys Arg Leu Ala Glu His Phe Pro Asn 
            340                 345                 350         


Lys Glu Ile Ile Lys Phe Ser Pro Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe Asn Gly Thr Tyr Asn Asn Gly Thr Tyr Asn Asp Gly 
385                 390                 395                 400 


Thr Asp Asn Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Gly Val Gly Lys Ala Ile Tyr Ala Pro Pro 
            420                 425                 430         


Ile Lys Gly Asn Ile Thr Cys Asn Ser Ser Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Lys Gly Asp Asn Asn Thr Asn Asn Thr Glu Thr 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Asn Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr 
                485                 490                 495     


Thr Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
        595                 600                 605             


Ser Ser Trp Ser Asn Arg Ser Gln Glu Glu Ile Trp Arg Asn Met Thr 
    610                 615                 620                 


Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr 
625                 630                 635                 640 


Thr Leu Leu Glu Ala Ser Gln Ile Gln Gln Glu Gln Asn Glu Lys Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Gln Asn Leu Trp Asn Trp Phe Asp Ile 
            660                 665                 670         


Thr Arg Trp Leu Trp Tyr Ile Lys Ser Arg Ile Glu Gly Arg Gly Ser 
        675                 680                 685             


Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
    690                 695                 700                 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
705                 710                 715     


<210>  4
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Arg Val Thr Gly Lys Trp Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Ser Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Val Thr Ser Ser Ala Ala Asn Val Thr Ser Asn Val 
    130                 135                 140                 


Thr Asn Asp Ala Asn Asn Ala Ser Asn Ala Asn Gly Arg Asn Val Ile 
145                 150                 155                 160 


Asn Glu Asp Met Gln Asn Cys Ser Phe Asn Ala Thr Thr Glu Ile Arg 
                165                 170                 175     


Asp Arg Lys Lys Glu Met Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val 
            180                 185                 190         


Pro Leu Asp Gly Glu Lys Ser Asp Asn Arg Tyr Arg Leu Ile Asn Cys 
        195                 200                 205             


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro 
    210                 215                 220                 


Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys 
225                 230                 235                 240 


Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr 
                245                 250                 255     


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
            260                 265                 270         


Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg Ser Glu Asn 
        275                 280                 285             


Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val 
    290                 295                 300                 


Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Thr Phe Tyr Ala Asn Asn Asp Ile Ile Gly Asp 
                325                 330                 335     


Ile Arg Gln Ala His Cys Asn Ile Ser Glu Glu Lys Trp Asn Asn Thr 
            340                 345                 350         


Leu His Arg Val Trp Lys Lys Leu Val Glu His Phe Pro Asn Lys Thr 
        355                 360                 365             


Thr Ile Arg Phe Asp Arg His Ser Gly Gly Asp Leu Glu Ile Thr Thr 
    370                 375                 380                 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
385                 390                 395                 400 


Leu Phe Asn Ile Thr Tyr Asn Ser Asn Tyr Thr Tyr Asn Asp Thr Lys 
                405                 410                 415     


His Asn Gly Thr Lys Val Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
            420                 425                 430         


Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile 
        435                 440                 445             


Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly Leu Leu Leu Thr 
    450                 455                 460                 


Arg Asp Gly Gly Asn Asn Ser Thr Glu Thr Glu Thr Phe Arg Pro Gly 
465                 470                 475                 480 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
                485                 490                 495     


Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Arg 
            500                 505                 510         


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile 
            580                 585                 590         


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser 
        595                 600                 605             


Ala Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Glu Thr Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp 
625                 630                 635                 640 


Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Asn Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Lys Trp Asn Ser Leu Trp Asp Trp Phe Gly Ile Ser Asn Trp Leu 
        675                 680                 685             


Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
    690                 695                 700                 


Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly 
705                 710                 715                 720 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Ser Pro Arg Gly Pro 
                725                 730                 735     


Asp Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp 
            740                 745                 750         


Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Glu Asp 
        755                 760                 765             


Leu Arg Asn Leu Cys Leu Phe Cys Tyr His Arg Leu Arg Asp Phe Ile 
    770                 775                 780                 


Leu Ile Ala Val Arg Val Val Glu Leu Leu Gly Arg Asn Ser Leu Arg 
785                 790                 795                 800 


Gly Leu Gln Arg Val Trp Glu Ala Leu Lys Val Leu Gly Asn Leu Val 
                805                 810                 815     


Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp 
            820                 825                 830         


Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu 
        835                 840                 845             


Leu Gln Arg Ile Cys Arg Ala Ile Tyr Asn Ile Pro Thr Arg Ile Arg 
    850                 855                 860                 


Gln Gly Phe Glu Ala Ala Leu Gln 
865                 870         


<210>  5
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Leu Leu Met Ile Ile Ile Cys Arg Gly Val Gly Asn 
            20                  25                  30          


Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Glu Ala Lys 
        35                  40                  45              


Ala Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Ile Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Ile Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Thr Cys Lys Asn Ile Thr Asn Asn Val Thr Asn Ile Phe Asn Ser Ser 
    130                 135                 140                 


Glu Gly Ile Asn Met Lys Glu Glu Ile Lys Asn Cys Ser Phe Asn Thr 
145                 150                 155                 160 


Thr Thr Glu Ile Arg Asp Lys Glu Lys Lys Glu Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Lys Pro Asp Ile Val Gln Leu Gly Glu Arg Asn Ser Ser Arg Tyr Ile 
            180                 185                 190         


Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Ser 
225                 230                 235                 240 


Asn Ile Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ser Glu Gly Glu Ile Met Ile 
            260                 265                 270         


Arg Ser Glu Asn Leu Thr Asp Asn Thr Lys Thr Ile Ile Val His Leu 
        275                 280                 285             


Asn Glu Ser Val Glu Ile Val Cys Ile Arg Pro Gly Asn Asn Thr Arg 
    290                 295                 300                 


Lys Gly Ile Arg Ile Gly Pro Gly Gln Val Phe Tyr Ala Thr Gly Asp 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Lys Trp 
                325                 330                 335     


Asn Thr Thr Leu Glu Lys Val Lys Lys Lys Leu Lys Glu His Phe Pro 
            340                 345                 350         


Asn Lys Thr Ile Asn Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Thr Lys Leu Phe Thr Asn Thr Thr Thr Asn Thr Thr Ile Leu Ile Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Phe Val Asn Met Trp Gln Glu Val Gly Arg Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Asn Ser Ser Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Val Arg Asp Gly Gly Ile Ser Asn Asp Thr Asn 
        435                 440                 445             


Asn Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
    450                 455                 460                 


Trp Arg Ser Glu Leu Tyr Ser Tyr Lys Val Val Glu Leu Lys Pro Leu 
465                 470                 475                 480 


Gly Val Ala Pro Thr Gly Ala Lys Arg Arg Val Val Glu Met Glu Arg 
                485                 490                 495     


Ser Lys Arg Ala Val Gly Ile Gly Ala Ala Leu Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Ala Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Ile Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Lys Glu 
        595                 600                 605             


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Val Ser 
    610                 615                 620                 


Asn Tyr Thr Glu Thr Ile Tyr Arg Leu Leu Glu Glu Ser Gln Thr Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Lys Glu Leu Leu Glu Leu Ser Lys Trp Asp Ser 
                645                 650                 655     


Leu Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Thr Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
        675                 680                 685             


Val Leu Ser Ile Val Arg Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg Pro Gly Gly 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Gly Lys Ser Ile Arg Leu 
                725                 730                 735     


Val Asn Gly Phe Leu Ala Leu Phe Trp Asp Asp Leu Arg Asn Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Leu Leu Arg Asp Phe Ile Leu Val Thr Ala Arg 
        755                 760                 765             


Ala Val Glu Leu Leu Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu 
    770                 775                 780                 


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
785                 790                 795                 800 


Ser Leu Leu Asp Thr Leu Ala Ile Ala Val Gly Glu Gly Thr Asp Arg 
                805                 810                 815     


Ile Ile Arg Ile Val Gln Ser Ile Cys Arg Ala Ile Tyr Asn Thr Pro 
            820                 825                 830         


Arg Arg Ile Arg Gln Gly Phe Glu Thr Ala Leu Leu 
        835                 840                 


<210>  6
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (791)..(791)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Met Arg Val Arg Gly Ile Arg Lys Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Ile Leu Met Ile Cys Ser Val Met Gly Asn 
            20                  25                  30          


Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Val Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Ile Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Cys Ser Thr Phe Asn Cys Ser Asn Asn Ala Gly Thr Ile Glu 
    130                 135                 140                 


Glu Gln Glu Leu Lys Asn Cys Ser Phe Asn Ala Thr Thr Val Val Arg 
145                 150                 155                 160 


Asp Lys Lys Gln Thr Val Ser Ala Leu Phe Tyr Lys Leu Asp Val Val 
                165                 170                 175     


Pro Leu Gly Gly Asp Asn Asn Asn Asn Asn Lys Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Lys Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val His Leu Asn Asp 
        275                 280                 285             


Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala Tyr Cys Asn Ile Asn Lys Asp Lys Trp Asn 
                325                 330                 335     


Lys Thr Leu Gln Gln Val Gly Lys Arg Leu Ala Glu His Phe Pro Asn 
            340                 345                 350         


Lys Glu Ile Ile Lys Phe Ser Pro Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe Asn Gly Thr Tyr Asn Asn Gly Thr Tyr Asn Asp Gly 
385                 390                 395                 400 


Thr Asp Asn Ser Asn Asp Thr Ile Thr Leu Leu Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Gly Val Gly Lys Ala Ile Tyr Ala Pro Pro 
            420                 425                 430         


Ile Lys Gly Asn Ile Thr Cys Asn Ser Ser Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Lys Gly Asp Asn Asn Thr Asn Asn Thr Glu Thr 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Asn Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr 
                485                 490                 495     


Thr Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
        595                 600                 605             


Ser Ser Trp Ser Asn Arg Ser Gln Glu Glu Ile Trp Arg Asn Met Thr 
    610                 615                 620                 


Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Thr Ile Tyr 
625                 630                 635                 640 


Thr Leu Leu Glu Ala Ser Gln Ile Gln Gln Glu Gln Asn Glu Lys Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Gln Asn Leu Trp Asn Trp Phe Asp Ile 
            660                 665                 670         


Thr Arg Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Lys Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Pro Leu Gln Thr Leu Thr Pro Asn 
705                 710                 715                 720 


Gln Arg Ala Pro Asp Arg Leu Gly Arg Ile Glu Glu Gly Gly Gly Glu 
                725                 730                 735     


Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu 
            740                 745                 750         


Phe Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His Arg Leu 
        755                 760                 765             


Arg Asp Phe Ile Leu Ile Ala Ala Arg Ala Ala Glu Leu Leu Gly Arg 
    770                 775                 780                 


Ser Ser Cys Lys Gly Leu Xaa Arg Gly Trp Glu Ile Leu Lys Tyr Leu 
785                 790                 795                 800 


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
                805                 810                 815     


Ser Leu Leu Asp Ile Ile Ala Ile Arg Val Ala Glu Gly Thr Asp Arg 
            820                 825                 830         


Ile Ile Glu Leu Ile Gln Arg Thr Gly Arg Ala Ile Leu Asn Ile Pro 
        835                 840                 845             


Thr Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
    850                 855                 860 


<210>  7
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Gly Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
        35                  40                  45              


Trp Thr Asp Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Thr Lys Ala 
    50                  55                  60                  


Tyr Asp Arg Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
65                  70                  75                  80  


Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
                85                  90                  95      


Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile 
            100                 105                 110         


Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
        115                 120                 125             


Leu Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val 
    130                 135                 140                 


Thr Asn Asp Met Asn Lys Glu Ile Arg Asn Cys Ser Phe Asn Thr Thr 
145                 150                 155                 160 


Thr Glu Ile Arg Asp Lys Lys Gln Gln Gly Tyr Ala Leu Phe Tyr Arg 
                165                 170                 175     


Pro Asp Ile Val Leu Leu Lys Glu Asn Arg Asn Asn Ser Asn Asn Ser 
            180                 185                 190         


Glu Tyr Ile Leu Ile Asn Cys Asn Ala Ser Thr Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Asn Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Ser Gly Lys Gly 
225                 230                 235                 240 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser 
                325                 330                 335     


Gly Ser Lys Trp Asn Glu Thr Leu Lys Arg Val Lys Glu Lys Leu Gln 
            340                 345                 350         


Glu Asn Tyr Asn Asn Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Thr Arg Leu Phe Asn Asn Asn Ala Thr Glu Asp 
385                 390                 395                 400 


Glu Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile 
            420                 425                 430         


Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp Gly Gly 
        435                 440                 445             


Glu Asp Asn Lys Thr Glu Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
    450                 455                 460                 


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Ile Glu Leu 
465                 470                 475                 480 


Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Glu Arg Val Val Glu 
                485                 490                 495     


Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Ser Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
        595                 600                 605             


Thr Asp Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile 
    610                 615                 620                 


Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Thr 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys 
                645                 650                 655     


Asn Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro Glu Ala Pro 
        675                 680                 685             


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
    690                 695                 700                 


Ser Thr Phe Leu 
705             


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


