<110> 	FELLOWS, ROSS FLINSPACH, MACK HAGAN, REBECCA LIU, YI NEFF, ROBERT WICKENDEN, ALAN XU, QINGHAO 
<120> 	PROTOXIN-II VARIANTS AND METHODS OF USE 
<130> 	JBI5038WOPCT 
<150> 	61/886,100 
<151> 	2013-10-03 
<160> 	407 
<170> 	PatentIn version 3.5 
<210> 	1 
<211> 	30 
<212> 	PRT 
<213> 	Thrixopelma pruriens 
<220> 
<221> 	MOD_RES 
<222> 	(30)..(30) 
<223> 	-COOH 
<400> 	1 
Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	2 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D12 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	2 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp Page 1 
<210> 	3 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D748 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	3 
Gly Pro Ala Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	4 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D751 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	4 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	5 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2292 polypeptide 
<220> 
<221> 	MOD_RES Page 2 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	5 
Gly Pro Arg Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	6 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D750 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	6 
Gly Pro Ser Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	7 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D1328 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	7 
Gly Pro Tyr Cys Gln Lys Trp Phe Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	8 Page 3 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D774 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	8 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	9 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D786 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	9 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	10 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2300 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	10 Page 4 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	11 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D791 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	11 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	12 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D1332 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	12 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	13 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
Page 5 <220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2512 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	13 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	14 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D1336 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	14 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	15 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D1337 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	15 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys Page 6 
1 5 10 15 Cys Cys Glu Gly Met Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	16 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2308 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	16 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	17 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2670 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	17 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	18 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> Page 7 
<223> 	Description of Artificial Sequence: Synthetic NV1D2674 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	18 
Gly Pro Ala Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	19 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2664 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	19 
Gly Pro Ala Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	20 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2671 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	20 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Page 8 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	21 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2675 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	21 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	22 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2665 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	22 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	23 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2668 Page 9 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	23 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	24 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2672 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	24 
Gly Pro Arg Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	25 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2662 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	25 
Gly Pro Arg Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Page 10 Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	26 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2669 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	26 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	27 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2673 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	27 
Gly Pro Ser Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	28 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2663 
polypeptide 
Page 11 

<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	28 
Gly Pro Ser Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	29 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2676 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	29 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	30 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2666 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	30 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Page 12 
JBI5038WOPCTseqlist_ST25 Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	31 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2816 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	31 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	32 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2735 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	32 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	33 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2739 polypeptide 
Page 13 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	33 
Gly Pro Ala Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	34 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2731 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	34 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	35 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2810 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	35 
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp Page 14 
<210> 	36 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2732 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	36 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	37 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2740 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	37 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	38 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2819 polypeptide 
Page 15 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	38 
Gly Pro Arg Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	39 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2729 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	39 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	40 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2733 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	40 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 Page 16 
<210> 	41 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2814 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	41 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	42 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2820 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	42 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	43 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2730 polypeptide 
<220> Page 17 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	43 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	44 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2734 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	44 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	45 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2738 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	45 
Gly Pro Ser Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Page 18 
<210> 	46 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2851 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	46 
Gly Pro Tyr Cys Gln Lys Trp Phe Lys Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	47 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2850 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	47 
Gly Pro Tyr Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	48 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2667 polypeptide 
<220> 
<221> 	MOD_RES Page 19 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	48 
Gly Pro Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	49 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2867 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	49 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	50 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2881 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	50 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Page 20 
<210> 	51 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2882 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	51 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	52 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2774 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	52 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	53 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2902 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) Page 21 
<223> 	-COOH 
<400> 	53 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	54 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2861 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	54 
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	55 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2870 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	55 
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	56 Page 22 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2775 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	56 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	57 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2893 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	57 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	58 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2887 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH Page 23 
<400> 	58 
Gly Pro Arg Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	59 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2772 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	59 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	60 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2896 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	60 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	61 
<211> 	32 Page 24 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2877 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	61 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	62 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2878 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	62 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	63 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2889 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
Page 25 
<400> 	63 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	64 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2889 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	64 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	65 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2773 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	65 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	66 
<211> 	32 
<212> 	PRT Page 26 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2890 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	66 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	67 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2899 polypeptide 

<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	67 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	68 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2905 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	68 Page 27 
Gly Pro Tyr Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	69 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2906 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	69 
Gly Pro Tyr Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	70 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2921 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	70 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	71 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence Page 28 <220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2922 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	71 
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	72 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2909 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	72 
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	73 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2910 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	73 
Page 29 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 	74 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2913 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	74 
Gly Pro Arg Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	75 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2914 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	75 
Gly Pro Arg Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	76 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
Page 30 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2917 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	76 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	77 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D2918 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	77 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	78 
<211> 	32 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1D3034 polypeptide 
<220> 
<221> 	MOD_RES 
<222> 	(32)..(32) 
<223> 	-COOH 
<400> 	78 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Page 31 
1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 79 
<211> 1977 
<212> PRT 
<213> Homo Sapiens 
<400> 79 
Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 1 5 10 15 
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 20 25 30 
Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 35 40 45 
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 50 55 60 
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 65 70 75 80 
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 85 90 95 
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 100 105 110 
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 115 120 125 
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 130 135 140 
Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 145 150 155 160 
Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 165 170 175 
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 180 185 190 
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly Page 32 
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 210 215 220 
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 225 230 235 240 
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 245 250 255 
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 260 265 270 
His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 275 280 285 
Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 290 295 300 
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 305 310 315 320 
Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 325 330 335 
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 340 345 350 
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 355 360 365 
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 370 375 380 
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 385 390 395 400 
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 405 410 415 
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 420 425 430 
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 435 440 445 
Page 33 
JBI5038WOPCTseqlist_ST25 Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 450 455 460 
Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 465 470 475 480 
Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 485 490 495 
Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 500 505 510 
Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 515 520 525 
Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 530 535 540 
Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 545 550 555 560 
Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 565 570 575 
Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 580 585 590 
Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 595 600 605 
Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 610 615 620 
Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 625 630 635 640 
Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 645 650 655 
Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 660 665 670 
Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 675 680 685 
Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 690 695 700 
Page 34 
Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 705 710 715 720 
Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 725 730 735 
Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 740 745 750 
Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 755 760 765 
Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 770 775 780 
Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 785 790 795 800 
Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 805 810 815 
Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 820 825 830 
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 835 840 845 
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 850 855 860 
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 865 870 875 880 
Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 885 890 895 
Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 900 905 910 
Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 915 920 925 
Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 930 935 940 
Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 945 950 955 960 
Page 35 
Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 965 970 975 
Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 980 985 990 
Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys Lys Pro Lys 995 1000 1005 
Ile Ser Arg Glu Ile Arg Gln Ala Glu Asp Leu Asn Thr Lys Lys 1010 1015 1020 
Glu Asn Tyr Ile Ser Asn His Thr Leu Ala Glu Met Ser Lys Gly 1025 1030 1035 
His Asn Phe Leu Lys Glu Lys Asp Lys Ile Ser Gly Phe Gly Ser 1040 1045 1050 
Ser Val Asp Lys His Leu Met Glu Asp Ser Asp Gly Gln Ser Phe 1055 1060 1065 
Ile His Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly 1070 1075 1080 
Glu Ser Asp Leu Glu Asn Met Asn Ala Glu Glu Leu Ser Ser Asp 1085 1090 1095 
Ser Asp Ser Glu Tyr Ser Lys Val Arg Leu Asn Arg Ser Ser Ser 1100 1105 1110 
Ser Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu Gly Glu 1115 1120 1125 
Glu Ala Glu Ala Glu Pro Met Asn Ser Asp Glu Pro Glu Ala Cys 1130 1135 1140 
Phe Thr Asp Gly Cys Val Arg Arg Phe Ser Cys Cys Gln Val Asn 1145 1150 1155 
Ile Glu Ser Gly Lys Gly Lys Ile Trp Trp Asn Ile Arg Lys Thr 1160 1165 1170 
Cys Tyr Lys Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val 1175 1180 1185 
Leu Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Page 36 
Tyr Ile Glu Arg Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala 1205 1210 1215 
Asp Lys Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys 1220 1225 1230 
Trp Ile Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys 1235 1240 1245 
Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu Val Thr Leu Val 1250 1255 1260 
Ala Asn Thr Leu Gly Tyr Ser Asp Leu Gly Pro Ile Lys Ser Leu 1265 1270 1275 
Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe 1280 1285 1290 
Glu Gly Met Arg Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro 1295 1300 1305 
Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile 1310 1315 1320 
Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu 1325 1330 1335 
Cys Ile Asn Thr Thr Asp Gly Ser Arg Phe Pro Ala Ser Gln Val 1340 1345 1350 
Pro Asn Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser Gln Asn 1355 1360 1365 
Val Arg Trp Lys Asn Leu Lys Val Asn Phe Asp Asn Val Gly Leu 1370 1375 1380 
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Thr 1385 1390 1395 
Ile Ile Met Tyr Ala Ala Val Asp Ser Val Asn Val Asp Lys Gln 1400 1405 1410 
Pro Lys Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Val 1415 1420 1425 
Page 37 
Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly 1430 1435 1440 
Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly 1445 1450 1455 
Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala 1460 1465 1470 
Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg 1475 1480 1485 
Pro Gly Asn Lys Ile Gln Gly Cys Ile Phe Asp Leu Val Thr Asn 1490 1495 1500 
Gln Ala Phe Asp Ile Ser Ile Met Val Leu Ile Cys Leu Asn Met 1505 1510 1515 
Val Thr Met Met Val Glu Lys Glu Gly Gln Ser Gln His Met Thr 1520 1525 1530 
Glu Val Leu Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr 1535 1540 1545 
Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe 1550 1555 1560 
Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Ile Ser 1565 1570 1575 
Ile Val Gly Met Phe Leu Ala Asp Leu Ile Glu Thr Tyr Phe Val 1580 1585 1590 
Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg 1595 1600 1605 
Ile Leu Arg Leu Val Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu 1610 1615 1620 
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu 1625 1630 1635 
Leu Leu Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser 1640 1645 1650 
Asn Phe Ala Tyr Val Lys Lys Glu Asp Gly Ile Asn Asp Met Phe 1655 1660 1665 
Page 38 
Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile 1670 1675 1680 
Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn 1685 1690 1695 
Ser Lys Pro Pro Asp Cys Asp Pro Lys Lys Val His Pro Gly Ser 1700 1705 1710 
Ser Val Glu Gly Asp Cys Gly Asn Pro Ser Val Gly Ile Phe Tyr 1715 1720 1725 
Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val Val Val Asn Met 1730 1735 1740 
Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala Thr Glu Glu 1745 1750 1755 
Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe Tyr Glu 1760 1765 1770 
Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe 1775 1780 1785 
Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu 1790 1795 1800 
Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro 1805 1810 1815 
Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala 1820 1825 1830 
Phe Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ser Leu 1835 1840 1845 
Arg Ser Gln Met Glu Glu Arg Phe Met Ser Ala Asn Pro Ser Lys 1850 1855 1860 
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu 1865 1870 1875 
Asp Val Ser Ala Thr Val Ile Gln Arg Ala Tyr Arg Arg Tyr Arg 1880 1885 1890 
Leu Arg Gln Asn Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp 1895 1900 1905 Page 39 
Gly Asp Arg Asp Asp Asp Leu Leu Asn Lys Lys Asp Met Ala Phe 1910 1915 1920 
Asp Asn Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp Ala Thr 1925 1930 1935 
Ser Ser Thr Thr Ser Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro 1940 1945 1950 
Asp Lys Glu Lys Tyr Glu Gln Asp Arg Thr Glu Lys Glu Asp Lys 1955 1960 1965 
Gly Lys Asp Ser Lys Glu Ser Lys Lys 1970 1975 
<210> 80 
<211> 20 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> Description of Artificial Sequence: Synthetic Linker peptide 
<400> 80 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 
Gly Gly Gly Ser 20 
<210> 81 
<211> 30 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> Description of Artificial Sequence: Synthetic Linker polypeptide 
<400> 81 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 30 
<210> 82 
<211> 8 
<212> PRT 
<213> Artificial Sequence 
Page 40 
<220> 
<223> 	Description of Artificial Sequence: Synthetic HRV3C cleavage site peptide 
<400> 	82 
Leu Glu Val Leu Phe Gln Gly Pro 1 5 
<210> 	83 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1007 (NV1D2775) Y1Q, W7Q, S11A, M19F polypeptide 
<400> 	83 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 Page 41 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Page 42 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
Page 43 
<210> 	84 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1007 (NV1D2775) Y1Q, W7Q, S11A, M19F polynucleotide 
<400> 84 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 Page 44 
tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg  1680  
aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc  1740  
ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag  1800  
aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc  1860  
ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag  1920  
ggaccacagt gccagaagtg gatgcagaca tgcgacgccg agcgcaagtg ctgcgaaggc  1980  
ttcgtgtgtc gcctgtggtg taaaaagaag ttgtggtga  2019  

<210> 	85 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1005 (NV1D2772) Y1R, W7Q, S11A, M19F polypeptide 
<400> 	85 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Page 45 
JBI5038WOPCTseqlist_ST25 Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Page 46 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 645 650 655 Page 47 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	86 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1005 (NV1D2772) Y1R, W7Q, S11A, M19F polynucleotide 
<400> 86 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 Page 48 
agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 
accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 
gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 
tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 
aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 
ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 
aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 
ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 
ggaccacggt gccagaagtg gatgcagaca tgcgacgccg agcgcaagtg ctgcgaaggc 1980 
ttcgtgtgtc gcctgtggtg taaaaagaag ttgtggtga 	2019 
<210> 	87 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1001 (NV1D2773) Y1S, W7Q, S11A, M19F polypeptide 
<400> 	87 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 Page 49 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Page 50 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Page 51 
JBI5038WOPCTseqlist_ST25 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	88 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1001 (NV1D2773) Y1S, W7Q, S11A, M19F polynucleotide 
<400> 88 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 Page 52 
ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccaagct gccagaagtg gatgcagaca tgcgacgccg agcgcaagtg ctgcgaaggc 1980 ttcgtgtgtc gcctgtggtg taaaaagaag ttgtggtga 2019 
<210> 	89 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1079 (NV1D2889) Y1S,M6F,S11A,M19F polypeptide 
<400> 	89 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Page 53 
JBI5038WOPCTseqlist_ST25 Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Page 54 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 Page 55 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	90 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1079 (NV1D2889) Y1S,M6F,S11A,M19F polynucleotide 
<400> 90 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 Page 56 
tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccaagct gccagaagtg gttctggaca tgcgacgccg agcgcaagtg ctgcgaaggc 1980 ttcgtgtgtc gcctgtggtg taaaaagaag ttgtggtga 2019 
<210> 	91 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1107 (NV1D2890) Y1S,M6F,S11A,M19L polypeptide 
<400> 	91 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Page 57 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Page 58 
JBI5038WOPCTseqlist_ST25 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Page 59 
JBI5038WOPCTseqlist_ST25 Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	92 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1107 (NV1D2890) Y1S,M6F,S11A,M19L polynucleotide 
<400> 92 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 Page 60 
aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccaagct gccagaagtg gttctggacc tgcgacgccg agcggaagtg ctgcgagggc 1980 ctggtgtgcc ggctgtggtg caagaagaag ctgtggtga 2019 
<210> 	93 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1063 (NV1D2913) Y1R,M6F,W7Q,S11A,M19F polypeptide 
<400> 	93 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Page 61 
JBI5038WOPCTseqlist_ST25 Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Page 62 Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Page 63 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Arg Cys Gln Lys Trp Phe Gln Thr Cys Asp Ala Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	94 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1063 (NV1D2913) Y1R,M6F,W7Q,S11A,M19F polynucleotide 
<400> 94 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 
agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 
ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 
tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 
gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 
ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 
caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 
cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 
ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 
ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 
aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 
gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 Page 64 
tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccacggt gccagaagtg gttccagaca tgcgacgccg agcgcaagtg ctgcgaaggc 1980 ttcgtgtgtc gcctgtggtg taaaaagaag ttgtggtga 2019 
<210> 	95 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1097 (NV1D2810), Y1Q,M6F,W7Q polypeptide 
<400> 	95 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 Page 65 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Page 66 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Page 67 
JBI5038WOPCTseqlist_ST25 Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540  
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560  
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575  
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590  
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605  
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620  
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640  
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 645 650 655  
Cys Cys Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670  
<210> <211> <212> <213>  96 1959 DNA Artificial Sequence  
<220> <223>  Description of Artificial Sequence: Synthetic NV1G1097 (NV1D2810), Y1Q,M6F,W7Q polynucleotide  
<400> 96 gggagccacc accaccacca ccacgacgcc cacaagagcg aggtggccca ccggttcaag  60  
gacctgggcg aggagaactt caaggccctg gtgctgatcg ccttcgccca gtacctgcag  120  
cagtgcccct tcgaggacca cgtgaagctg gtgaacgagg tgaccgagtt cgccaagacc  180  
tgcgtggccg acgagagcgc cgagaactgc gacaagagcc tgcacaccct gttcggcgac  240  
aagctgtgca ccgtggccac cctgcgggag acctacggcg agatggccga ctgctgcgcc  300  
aagcaggagc ccgagcggaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg  360  
ccccggctgg tgcggcccga ggtggacgtg atgtgcaccg ccttccacga caacgaggag  420  
accttcctga agaagtacct gtacgagatc gcccggcggc acccctactt ctacgccccc  480  
gagctgctgt tcttcgccaa gcggtacaag gccgccttca ccgagtgctg ccaggccgcc Page 68  540  

gacaaggccg cctgcctgct gcccaagctg gacgagctgc gggacgaggg caaggccagc 600 agcgccaagc agcggctgaa gtgcgccagc ctgcagaagt tcggcgagcg ggccttcaag 660 gcctgggccg tggcccggct gagccagcgg ttccccaagg ccgagttcgc cgaggtgagc 720 aagctggtga ccgacctgac caaggtgcac accgagtgct gccacggcga cctgctggag 780 tgcgccgacg accgggccga cctggccaag tacatctgcg agaaccagga cagcatcagc 840 agcaagctga aggagtgctg cgagaagccc ctgctggaga agagccactg catcgccgag 900 gtggagaacg acgagatgcc cgccgacctg cccagcctgg ccgccgactt cgtggagagc 960 aaggacgtgt gcaagaacta cgccgaggcc aaggacgtgt tcctgggcat gttcctgtac 1020 gagtacgccc ggcggcaccc cgactacagc gtggtgctgc tgctgcggct ggccaagacc 1080 tacgagacca ccctggagaa gtgctgcgcc gccgccgacc cccacgagtg ctacgccaag 1140 gtgttcgacg agttcaagcc cctggtggag gagccccaga acctgatcaa gcagaactgc 1200 gagctgttcg agcagctggg cgagtacaag ttccagaacg ccctgctggt gcggtacacc 1260 aagaaggtgc cccaggtgag cacccccacc ctggtggagg tgagccggaa cctgggcaag 1320 gtgggcagca agtgctgcaa gcaccccgag gccaagcgga tgccctgcgc cgaggactac 1380 ctgagcgtgg tgctgaacca gctgtgcgtg ctgcacgaga agacccccgt gagcgaccgg 1440 gtgaccaagt gctgcaccga gagcctggtg aaccggcggc cctgcttcag cgccctggag 1500 gtggacgaga cctacgtgcc caaggagttc aacgccgaga ccttcacctt ccacgccgac 1560 atctgcaccc tgagcgagaa ggagcggcag atcaagaagc agaccgccct ggtggagctg 1620 gtgaagcaca agcccaaggc caccaaggag cagctgaagg ccgtgatgga cgacttcgcc 1680 gccttcgtgg agaagtgctg caaggccgac gacaaggaga cctgcttcgc cgaggagggc 1740 aagaagctgg tggccgccag ccaggccgcc ctgggcctgg gcagcggcgg cggcggcagc 1800 ggcggcggcg gatctggtgg aggtggcagt ggaggagggg gatccctcga ggtcctcttt 1860 cagggaccac agtgccagaa gtggttccag acatgcgaca gcgagcgcaa gtgctgcgaa 1920 ggcatggtgt gtcgcctgtg gtgtaaaaag aagttgtgg 1959 
<210> 	97 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1123 (NV1D2882), Y1A,M6F,W7Q,M19L polypeptide 
<400> 	97 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 Page 69 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Page 70 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Page 71 
JBI5038WOPCTseqlist_ST25 Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525  
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540  
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560  
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575  
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590  
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605  
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620  
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640  
Gly Pro Ala Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 645 650 655  
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670  
<210> <211> <212> <213>  98 2019 DNA Artificial Sequence  
<220> <223>  Description of Artificial Sequence: Synthetic NV1G1123 (NV1D2882), Y1A,M6F,W7Q,M19L polynucleotide  
<400> 98 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg  60  
agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac  120  
ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag  180  
tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc  240  
gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag  300  
ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag  360  
caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc Page 72  420  

cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccagcct gccagaagtg gttccagacc tgcgacagcg agcggaagtg ctgcgagggc 1980 ctggtgtgcc ggctgtggtg caagaagaag ctgtggtga 2019 
<210> 99 
<211> 672 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1127 Page 73 
<400> 99 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Page 74 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 Page 75 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510  
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525  
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540  
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560  
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575  
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590  
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605  
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620  
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640  
Gly Pro Gln Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 645 650 655  
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670  
<210> <211> <212> <213>  100 2019 DNA Artificial Sequence  
<220> <223>  Description of Artificial Sequence: Synthetic NV1G1127 (NV1D2870), Y1Q,M6F,W7Q,M19L polynucleotide  
<400> 100 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg  60  
agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac  120  
ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag  180  
tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc Page 76  240  

gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 ggaccacagt gccagaagtg gttccagacc tgcgacagcg agcggaagtg ctgcgagggc 1980 ctggtgtgcc ggctgtggtg caagaagaag ctgtggtga 2019 
<210> 101 
Page 77 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1083 (NV1D2878), Y1S,M6F,W7Q,M19L polypeptide 
<400> 	101 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Page 78 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Page 79 
JBI5038WOPCTseqlist_ST25 Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 

Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Ser Cys Gln Lys Trp Phe Gln Thr Cys Asp Ser Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 660 665 670 
<210> 	102 
<211> 	2019 
<212> 	DNA 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1083 (NV1D2878), Y1S,M6F,W7Q,M19L polynucleotide 
<400> 	102 
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 	60 Page 80 
agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1800 aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc 1860 ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag 1920 
Page 81 
JBI5038WOPCTseqlist_ST25  
ggaccaagct gccagaagtg gttccagaca tgcgacagcg agcgcaagtg ctgcgaaggc  1980  
ttagtgtgtc gcctgtggtg taaaaagaag ttgtggtga  2019  

<210> 	103 
<211> 	672 
<212> 	PRT 
<213> 	Artificial Sequence 
<220> 
<223> 	Description of Artificial Sequence: Synthetic NV1G1153 (NV1D3034) fusion protein 
<400> 	103 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Page 82 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 Page 83 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590 
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605 
Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 610 615 620 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln 625 630 635 640 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 645 650 655 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 660 665 670 
<210> 104 
<211> 2019 
<212> DNA 
<213> Artificial Sequence 
Page 84 
<220> 
<223> Description of Artificial Sequence: Synthetic NV1G1153 (NV1D3034)
 fusion polynucleotide 
<400> 104 atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggg 60 agccaccacc accaccacca cgacgcccac aagagcgagg tggcccaccg gttcaaggac 120 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 180 tgccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 240 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 300 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 360 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 420 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 480 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 540 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 600 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 660 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 720 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 780 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 840 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 900 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 960 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1020 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1080 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1140 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1200 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1260 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1320 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1380 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1440 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1500 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1560 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1620 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1680 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1740 
Page 85 
JBI5038WOPCTseqlist_ST25 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag  1800  
aagctggtgg ccgccagcca ggccgccctg ggcctgggca gcggcggcgg cggcagcggc  1860  
ggcggcggat ctggtggagg tggcagtgga ggagggggat ccctcgaggt cctctttcag  1920  
ggaccacagt gccagaagtg gatgcagacc tgcgaccggg agcggaagtg ctgcgagggc  1980  
ttcgtgtgca ccctgtggtg ccggaagaag ctgtggtga  2019  
<210> <211> <212> <213>  105 2016 PRT Homo sapiens  
<400>  105  
Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 1 5 10 15  
Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 20 25 30  
Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 35 40 45  
Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 50 55 60  
Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 65 70 75 80  
Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 85 90 95  
Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 100 105 110  
Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 115 120 125  
Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 130 135 140  
Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 145 150 155 160  
Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 165 170 175  
Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro Page 86  

Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 195 200 205 
Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 210 215 220 
Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 225 230 235 240 
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 245 250 255 
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 260 265 270 
Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 275 280 285 
Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 290 295 300 
Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 305 310 315 320 
Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 325 330 335 
Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 340 345 350 
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 355 360 365 
Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 370 375 380 
Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 385 390 395 400 
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 405 410 415 
Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 420 425 430 
Page 87 
JBI5038WOPCTseqlist_ST25 Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 435 440 445 
Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 450 455 460 
Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 465 470 475 480 
Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 485 490 495 
Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 500 505 510 
Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 515 520 525 
Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 530 535 540 
Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 545 550 555 560 
Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 565 570 575 
Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 580 585 590 
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 595 600 605 
Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 610 615 620 
Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 625 630 635 640 
Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 645 650 655 
Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 660 665 670 
Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 675 680 685 
Page 88 
Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 690 695 700 
Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 705 710 715 720 
Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 725 730 735 
Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 740 745 750 
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 755 760 765 
Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 770 775 780 
Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 785 790 795 800 
Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 805 810 815 
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 820 825 830 
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 835 840 845 
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 850 855 860 
Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 865 870 875 880 
Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 885 890 895 
Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 900 905 910 
Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 915 920 925 
Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 930 935 940 Page 89 
Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 945 950 955 960 
Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 965 970 975 
Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 980 985 990 
Ala Ala Leu Ala Ala Gln Gly Gln Leu Pro Ser Cys Ile Ala Thr Pro 995 1000 1005 
Tyr Ser Pro Pro Pro Pro Glu 1010 1015 
Lys Glu Thr Arg Phe Glu Glu 1025 1030 
Pro Gly Asp Pro Glu Pro Val 1040 1045 
Ser Asp Thr Asp Asp Gln Glu 1055 1060 
Thr Glu Glu Glu Ser Ser Lys 1070 1075 
Gly Gly Pro Glu Ala Pro Pro 1085 1090 
Ser Ala Thr Ala Ser Ser Glu 1100 1105 
Asp Trp Arg Gln Gln Trp Lys 1115 1120 
Gly Glu Thr Pro Glu Asp Ser 1130 1135 
Met Thr Asn Thr Ala Glu Leu 1145 1150 
Gln Asp Val Lys Asp Pro Glu 1160 1165 
Arg Arg Cys Pro Cys Cys Ala 
Thr Glu Lys Val Pro 1020 
Gly Glu Gln Pro Gly 1035 
Cys Val Pro Ile Ala 1050 
Glu Asp Glu Glu Asn 1065 
Gln Gln Glu Ser Gln 1080 
Asp Ser Arg Thr Trp 1095 
Ala Glu Ala Ser Ala 1110 
Ala Glu Pro Gln Ala 1125 
Cys Ser Glu Gly Ser 1140 
Leu Glu Gln Ile Pro 1155 
Asp Cys Phe Thr Glu 1170 
Val Asp Thr Thr Gln Page 90 
Pro Thr Arg 
Gln Gly Thr 
Val Ala Glu 
Ser Leu Gly 
Pro Val Ser 
Ser Gln Val 
Ser Gln Ala 
Pro Gly Cys 
Thr Ala Asp 
Asp Leu Gly 
Gly Cys Val 
Ala Pro Gly 
Lys Val Trp Trp Arg Leu Arg Lys Thr Cys Tyr His Ile Val Glu 1190 1195 1200 
His Ser Trp Phe Glu Thr Phe Ile Ile Phe Met Ile Leu Leu Ser 1205 1210 1215 
Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Leu Glu Glu Arg Lys 1220 1225 1230 
Thr Ile Lys Val Leu Leu Glu Tyr Ala Asp Lys Met Phe Thr Tyr 1235 1240 1245 
Val Phe Val Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe 1250 1255 1260 
Lys Lys Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 1265 1270 1275 
Val Asp Val Ser Leu Val Ser Leu Val Ala Asn Thr Leu Gly Phe 1280 1285 1290 
Ala Glu Met Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu 1295 1300 1305 
Arg Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val 1310 1315 1320 
Val Asn Ala Leu Val Gly Ala Ile Pro Ser Ile Met Asn Val Leu 1325 1330 1335 
Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val 1340 1345 1350 
Asn Leu Phe Ala Gly Lys Phe Gly Arg Cys Ile Asn Gln Thr Glu 1355 1360 1365 
Gly Asp Leu Pro Leu Asn Tyr Thr Ile Val Asn Asn Lys Ser Gln 1370 1375 1380 
Cys Glu Ser Leu Asn Leu Thr Gly Glu Leu Tyr Trp Thr Lys Val 1385 1390 1395 
Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu Ala Leu Leu 1400 1405 1410 
Page 91 
Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala Ala 1415 1420 1425 
Val Asp Ser Arg Gly Tyr Glu Glu Gln Pro Gln Trp Glu Tyr Asn 1430 1435 1440 
Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser 1445 1450 1455 
Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe 1460 1465 1470 
Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr 1475 1480 1485 
Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 1490 1495 1500 
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys Tyr Gln 1505 1510 1515 
Gly Phe Ile Phe Asp Ile Val Thr Lys Gln Ala Phe Asp Val Thr 1520 1525 1530 
Ile Met Phe Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu 1535 1540 1545 
Thr Asp Asp Gln Ser Pro Glu Lys Ile Asn Ile Leu Ala Lys Ile 1550 1555 1560 
Asn Leu Leu Phe Val Ala Ile Phe Thr Gly Glu Cys Ile Val Lys 1565 1570 1575 
Leu Ala Ala Leu Arg His Tyr Tyr Phe Thr Asn Ser Trp Asn Ile 1580 1585 1590 
Phe Asp Phe Val Val Val Ile Leu Ser Ile Val Gly Thr Val Leu 1595 1600 1605 
Ser Asp Ile Ile Gln Lys Tyr Phe Phe Ser Pro Thr Leu Phe Arg 1610 1615 1620 
Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Ile Arg 1625 1630 1635 
Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser 1640 1645 1650 
Page 92 
Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met 1655 1660 1665 
Phe Ile Tyr Ser Ile Phe Gly Met Ala Asn Phe Ala Tyr Val Lys 1670 1675 1680 
Trp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Gln Thr Phe Ala 1685 1690 1695 
Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp 1700 1705 1710 
Asp Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys 1715 1720 1725 
Asp Pro Thr Leu Pro Asn Ser Asn Gly Ser Arg Gly Asp Cys Gly 1730 1735 1740 
Ser Pro Ala Val Gly Ile Leu Phe Phe Thr Thr Tyr Ile Ile Ile 1745 1750 1755 
Ser Phe Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu 1760 1765 1770 
Asn Phe Ser Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu 1775 1780 1785 
Asp Asp Phe Asp Met Phe Tyr Glu Ile Trp Glu Lys Phe Asp Pro 1790 1795 1800 
Glu Ala Thr Gln Phe Ile Glu Tyr Ser Val Leu Ser Asp Phe Ala 1805 1810 1815 
Asp Ala Leu Ser Glu Pro Leu Arg Ile Ala Lys Pro Asn Gln Ile 1820 1825 1830 
Ser Leu Ile Asn Met Asp Leu Pro Met Val Ser Gly Asp Arg Ile 1835 1840 1845 
His Cys Met Asp Ile Leu Phe Ala Phe Thr Lys Arg Val Leu Gly 1850 1855 1860 
Glu Ser Gly Glu Met Asp Ala Leu Lys Ile Gln Met Glu Glu Lys 1865 1870 1875 
Phe Met Ala Ala Asn Pro Ser Lys Ile Ser Tyr Glu Pro Ile Thr 1880 1885 1890 Page 93 
Thr Thr Leu Arg Arg Lys His Glu Glu Val Ser Ala Met Val Ile 1895 1900 1905 
Gln Arg Ala Phe Arg Arg His Leu Leu Gln Arg Ser Leu Lys His 1910 1915 1920 
Ala Ser Phe Leu Phe Arg Gln Gln Ala Gly Ser Gly Leu Ser Glu 1925 1930 1935 
Glu Asp Ala Pro Glu Arg Glu Gly Leu Ile Ala Tyr Val Met Ser 1940 1945 1950 
Glu Asn Phe Ser Arg Pro Leu Gly Pro Pro Ser Ser Ser Ser Ile 1955 1960 1965 
Ser Ser Thr Ser Phe Pro Pro Ser Tyr Asp Ser Val Thr Arg Ala 1970 1975 1980 
Thr Ser Asp Asn Leu Gln Val Arg Gly Ser Asp Tyr Ser His Ser 1985 1990 1995 
Glu Asp Leu Ala Asp Phe Pro Pro Ser Pro Asp Arg Asp Arg Glu 2000 2005 2010 
Ser Ile Val 2015 
<210> 106 
<211> 612 
<212> PRT 
<213> Homo sapiens 
<400> 106 
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 1 5 10 15 
Ile Gln Ala Gly Ser His His His His His His Asp Ala His Lys Ser 20 25 30 
Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 35 40 45 
Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 50 55 60 
Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 65 70 75 80 
Page 94 
Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 85 90 95 
Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 100 105 110 
Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 115 120 125 
Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 130 135 140 
Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 145 150 155 160 
Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 165 170 175 
Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 180 185 190 
Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 195 200 205 
Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 210 215 220 
Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 225 230 235 240 
Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 245 250 255 
Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 260 265 270 
Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 275 280 285 
Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 290 295 300 
Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 305 310 315 320 
Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Page 95 
JBI5038WOPCTseqlist_ST25 325 330 335 
Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 340 345 350 
Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 355 360 365 
Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 370 375 380 
Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 385 390 395 400 
Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 405 410 415 
Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 420 425 430 
Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 435 440 445 
Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 450 455 460 
Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 465 470 475 480 
Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 485 490 495 
Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 500 505 510 
Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 515 520 525 
Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 530 535 540 
Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 545 550 555 560 
Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 565 570 575 
Page 96 
JBI5038WOPCTseqlist_ST25 Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 580 585 590  
Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 595 600 605  
Ala Leu Gly Leu 610  
<210> <211> <212> <213>  107 93 DNA Thrixopelma pruriens  
<400> 107 tactgccaga agtggatgtg gacatgcgac agcgagcgca agtgctgcga aggcatggtg  60  
tgtcgcctgt ggtgtaaaaa gaagttgtgg tga  93  
<210> <211> <212> <213>  108 6 PRT Artificial Sequence  
<220> <223>  Description of Artificial Sequence: Synthetic 6xHis tag  
<400>  108  
His His His His His His 1 5  
<210> <211> <212> <213>  109 30 PRT Artificial sequence  
<220> <223>  variant (-GP) NV1D2773  
<220> <221> <222> <223>  MOD_RES (30)..(30) -COOH  
<400>  109  
Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys 1 5 10 15  
Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30  
<210> <211>  110 30  Page 97  

<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant (-GP) NV1D2773-NH2 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -NH2 
<400> 110 
Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 111 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2775-NH2 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -NH2 
<400> 111 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 112 
<211> 30 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2890-NH2 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -NH2 
<400> 112 
Ser Cys Gln Lys Trp Phe Trp Thr Cys Asp Ala Glu Arg Lys Cys Cys Page 98 
1 5 	10 15 
Glu Gly Leu Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 113 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2974 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 113 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 114 
<211> 30 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant (-GP) N-Ac-NV1D2974-NH2 
<220> 
<221> MOD_RES 
<222> (1)..(1) 
<223> ACETYLATION 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -NH2 
<400> 114 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 115 
<211> 30 
<212> 	PRT Page 99 
<213> Artificial sequence 
<220> 
<223> Variant (-GP) N-Ac-NV1D2974 
<220> 
<221> MOD_RES 
<222> (1)..(1) 
<223> ACETYLATION 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -NH2 
<400> 115 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 116 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3034 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 116 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 117 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3034-NH2 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-NH2 Page 100 
<400> 117 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 118 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> NV1D3034-NH-butyl 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> NH-CH2-CH2-CH2-CH3 
<400> 118 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 119 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3034-NH-methyl 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -NH-CH3 
<400> 119 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 120 
<211> 30 
<212> PRT 
<213> 	Artificial sequence Page 101 <220> 
<223> Variant (-GP) N-Ac-NV1D3034 
<220> 
<221> MOD_RES 
<222> (1)..(1) 
<223> ACETYLATION 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -COOH 
<400> 120 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 121 
<211> 30 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant (-GP) N-Ac-NV1D3034-NH2 
<220> 
<221> MOD_RES 
<222> (1)..(1) 
<223> ACETYLATION 
<220> 
<221> MOD_RES 
<222> (30)..(30) 
<223> -NH2 
<400> 121 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys 1 5 10 15 
Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 122 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3368 
Page 102 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 122 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Thr Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 123 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3368-NH2 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -NH2 
<400> 123 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Thr Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 124 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2969 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 124 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Page 103 <210> 125 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2970 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 125 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 126 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2971 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 126 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 127 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2972 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 	127 Page 104 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 30 
<210> 128 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2973 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 128 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 129 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D2974 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 129 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 130 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> Page 105 
<223> Variant NV1D2974-NH2 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -NH2 
<400> 130 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 131 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3004 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 131 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 132 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3005 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 132 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp Page 106 
<210> 133 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3006 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 133 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 134 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3007 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 134 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 135 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3012 
<220> 
<221> MOD_RES 
<222> 	(32)..(32) Page 107 
<223> -COOH 
<400> 135 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 136 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3013 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 136 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 137 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3014 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 137 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 138 
<211> 32 
<212> 	PRT Page 108 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3015 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 138 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 139 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3016 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 139 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 140 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3017 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 140 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Page 109 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 30 
<210> 141 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3018 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 141 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 142 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3019 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 142 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 143 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3020 
Page 110 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 143 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 144 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3030 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 144 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 145 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3031 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 145 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Page 111 <210> 146 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3032 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 146 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 147 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3033 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 147 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 148 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3035 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 	148 Page 112 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 149 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3036 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 149 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 150 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3044 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 150 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 151 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> Page 113 
<223> Variant NV1D3045 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 151 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 152 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3048 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 152 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 153 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3050 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 153 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp Page 114 
<210> 154 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3051 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 154 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 155 
<211> 32 
<212> PRT 
<213> Artificial sequence 

<220> 
<223> Variant NV1D3052 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 155 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 156 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3056 
<220> 
<221> MOD_RES 
<222> 	(32)..(32) Page 115 
<223> -COOH 
<400> 156 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 157 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3057 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 157 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 158 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3058 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 158 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 159 
<211> 32 
<212> 	PRT Page 116 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3062 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 159 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 160 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3109 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 160 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 161 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3121 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 161 
Gly Pro Gln Cys Gln Lys Trp Met Trp Thr Cys Asp Arg Lys Arg Lys 1 5 10 15 
Page 117 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 162 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3249 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 162 
Gly Pro Ala Ala Ala Ala Ala Gln Cys Gln Lys Trp Met Gln Thr Cys 1 5 10 15 
Asp Ala Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys 20 25 30 
Lys Lys Lys Leu Trp 35 
<210> 163 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3251 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 163 
Gly Pro Ala Pro Ala Pro Ala Gln Cys Gln Lys Trp Met Gln Thr Cys 1 5 10 15 
Asp Ala Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys 20 25 30 
Lys Lys Lys Leu Trp 35 
<210> 	164 Page 118 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3252 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 164 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala 35 
<210> 165 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3254 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 165 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Gly Gly Gly Gly Gly 35 
<210> 166 
<211> 64 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3256 
Page 119 <220> 
<221> MOD_RES 
<222> (64)..(64) 
<223> -COOH 
<400> 166 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Arg Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Gly Ser Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 35 40 45 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 50 55 60 
<210> 167 
<211> 62 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3257 
<220> 
<221> MOD_RES 
<222> (62)..(62) 
<223> -COOH 
<400> 167 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys 35 40 45 
Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg Cys Cys 50 55 60 
<210> 168 
<211> 74 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3259 Page 120 <220> 
<221> MOD_RES 
<222> (74)..(74) 
<223> -COOH 
<400> 168 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp 50 55 60 
Cys Arg Asp His Ser Arg Cys Cys Gly Arg 65 70 
<210> 169 
<211> 74 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3260 
<220> 
<221> MOD_RES 
<222> (74)..(74) 
<223> -COOH 
<400> 169 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Arg Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Gln Cys Gln Lys 35 40 45 
Trp Met Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys Glu Gly Phe Val 50 55 60 
Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 65 70 
Page 121 <210> 170 
<211> 72 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3261 
<220> 
<221> MOD_RES 
<222> (72)..(72) 
<223> -COOH 
<400> 170 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp 50 55 60 
Cys Arg Asp His Ser Arg Cys Cys 65 70 
<210> 171 
<211> 72 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3262 
<220> 
<221> MOD_RES 
<222> (72)..(72) 
<223> -COOH 
<400> 171 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Gln Cys Gln Lys Trp Met Page 122 
Gln Thr Cys Asp Ala Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Arg 50 55 60 
Leu Trp Cys Lys Lys Lys Leu Trp 65 70 
<210> 172 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3339 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 172 
Gly Pro Gln Cys Arg Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 173 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3340 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 173 
Gly Pro Gln Cys Lys Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 174 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 123 <220> 
<223> Variant NV1D3341 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 174 
Gly Pro Gln Cys Thr Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 175 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3342 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 175 
Gly Pro Gln Cys Ala Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 176 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3344 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 176 
Gly Pro Gln Cys Glu Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Page 124 Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 177 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3345 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 177 
Gly Pro Gln Cys Ser Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 178 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3346 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 178 
Gly Pro Gln Cys Gln Arg Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 179 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3347 
<220> Page 125 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 179 
Gly Pro Gln Cys Gln Thr Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 180 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3348 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 180 
Gly Pro Gln Cys Gln Ala Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 181 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3349 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 181 
Gly Pro Gln Cys Gln Asp Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	182 Page 126 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3350 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 182 
Gly Pro Gln Cys Gln Glu Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 183 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3351 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 183 
Gly Pro Gln Cys Gln Gln Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 184 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3352 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 184 
Page 127 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Ser Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 185 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3353 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 185 
Gly Pro Gln Cys Gln Lys Trp Met Gln Arg Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 186 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3354 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 186 
Gly Pro Gln Cys Gln Lys Trp Met Gln Lys Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 187 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3356 Page 128 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 187 
Gly Pro Gln Cys Gln Lys Trp Met Gln Asp Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 188 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3357 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 188 
Gly Pro Gln Cys Gln Lys Trp Met Gln Glu Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 189 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3358 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 189 
Gly Pro Gln Cys Gln Lys Trp Met Gln Gln Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 Page 129 
<210> 190 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3359 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 190 
Gly Pro Gln Cys Gln Lys Trp Met Gln Ser Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 191 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3360 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 191 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Arg Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 192 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3361 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 130 
<400> 192 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Lys Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 193 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3362 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 193 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Thr Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 194 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3363 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 194 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Ala Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 195 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 131 <220> 
<223> Variant NV1D3365 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 195 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Gln Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 196 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3366 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 196 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Ser Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 197 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3367 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 197 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Gln Arg Lys 1 5 10 15 
Page 132 Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 198 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3368 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 198 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Thr Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 199 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3369 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 199 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Lys Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 200 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3370 
<220> Page 133 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 200 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Thr Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 201 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3371 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 201 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Ala Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 202 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3372 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 202 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Asp Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	203 Page 134 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3374 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 203 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Gln Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 204 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3375 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 204 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Ser Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 205 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3376 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 205 
Page 135 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Arg 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 206 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3377 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 206 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Thr 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 207 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3378 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 207 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Ala 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 208 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3379 Page 136 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 208 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Asp 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 209 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3380 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 209 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Glu 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 210 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3381 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 210 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Gln 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 Page 137 
<210> 211 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3382 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 211 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Ser 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 212 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3383 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 212 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Arg Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 213 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3384 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 138 
<400> 213 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Lys Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 214 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3385 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 214 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Thr Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 215 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3386 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 215 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Ala Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 216 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 139 <220> 
<223> Variant NV1D3387 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 216 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Asp Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 217 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3388 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 217 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Gln Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 218 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3389 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 218 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Page 140 Cys Cys Ser Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 219 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3390 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 219 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Arg Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 220 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3391 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 220 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Lys Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 221 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3392 

<220> Page 141 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 221 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Thr Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 222 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3393 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 222 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Ala Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 223 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3394 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 223 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Asp Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	224 Page 142 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3396 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 224 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gln Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 225 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3397 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 225 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Ser Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 226 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3398 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 226 
Page 143 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 227 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3399 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 227 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Thr Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 228 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3400 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 228 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Gln Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 229 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3401 Page 144 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 229 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Arg Lys Leu Trp 20 25 30 
<210> 230 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3403 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 230 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Ala Lys Leu Trp 20 25 30 
<210> 231 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3408 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 231 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Arg Leu Trp 20 25 30 Page 145 
<210> 232 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3409 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 232 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Thr Leu Trp 20 25 30 
<210> 233 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3410 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 233 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Ala Leu Trp 20 25 30 
<210> 234 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3413 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 146 
<400> 234 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Gln Leu Trp 20 25 30 
<210> 235 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3414 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 235 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Ser Leu Trp 20 25 30 
<210> 236 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3419 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 236 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Asp 20 25 30 
<210> 237 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 147 <220> 
<223> Variant NV1D3423 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 237 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Arg Arg Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 238 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3424 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 238 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Lys Arg Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 239 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3425 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 239 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Arg Arg Arg Asp Lys 1 5 10 15 
Page 148 Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 240 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3426 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 240 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Lys Arg Lys Asp Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 241 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3427 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 241 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Arg Arg Arg Glu Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 242 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3428 
<220> Page 149 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 242 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Lys Arg Lys Glu Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 243 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3430 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 243 
Gly Pro Gln Cys Gln Asp Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Lys Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 244 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3431 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 244 
Gly Pro Gln Cys Gln Glu Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Lys Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	245 Page 150 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3432 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 245 
Gly Pro Gln Cys Gln Glu Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Arg Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 246 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3439 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 246 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Gly 20 25 30 
<210> 247 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3465 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 247 
Page 151 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Phe Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 248 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3466 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 248 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Glu Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 249 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3467 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 249 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Gly Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 250 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3470 Page 152 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 250 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Leu Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 251 
<211> 44 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3510 
<220> 
<221> MOD_RES 
<222> (44)..(44) 
<223> -COOH 
<400> 251 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Ser Pro Gly Ala Arg Ala Phe 35 40 
<210> 252 
<211> 39 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3511 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 252 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Page 153 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ser Pro Gly Ala Arg Ala Phe 35 
<210> 253 
<211> 49 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3512 
<220> 
<221> MOD_RES 
<222> (49)..(49) 
<223> -COOH 
<400> 253 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Asp Gly Pro Trp Arg Lys 
35  
Met  
<210>  254  
<211>  44  
<212>  PRT  
<213>  Artificial sequence  
<220>  
<223>  Variant NV1D3513  
<220>  
<221>  MOD_RES  
<222>  (44)..(44)  
<223>  -COOH  
<400>  254  

40 45 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp Page 154 
Ala Pro Ala Pro Ala Asp Gly Pro Trp Arg Lys Met 
35 40 
<210> 255 
<211> 39 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3514 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 255 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Asp Gly Pro Trp Arg Lys Met 35 
<210> 256 
<211> 49 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3515 
<220> 
<221> MOD_RES 
<222> (49)..(49) 
<223> -COOH 
<400> 256 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Phe Gly Gln Lys Ala Ser 35 40 45 
Page 155 
<210> 257 
<211> 44 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3516 
<220> 
<221> MOD_RES 
<222> (44)..(44) 
<223> -COOH 
<400> 257 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Phe Gly Gln Lys Ala Ser Ser 35 40 
<210> 258 
<211> 39 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3517 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 258 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Phe Gly Gln Lys Ala Ser Ser 35 
<210> 259 
<211> 58 
<212> 	PRT Page 156 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3518 
<220> 
<221> MOD_RES 
<222> (58)..(58) 
<223> -COOH 
<400> 259 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gln Arg Phe Val Thr Gly 35 40 45 
His Phe Gly Gly Leu Tyr Pro Ala Asn Gly 50 55 
<210> 260 
<211> 53 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3519 
<220> 
<221> MOD_RES 
<222> (53)..(53) 
<223> -COOH 
<400> 260 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu 35 40 45 
Tyr Pro Ala Asn Gly 50 
<210> 261 
<211> 	48 Page 157 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3520 
<220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 261 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala Asn Gly 35 40 45 
<210> 262 
<211> 53 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3521 
<220> 
<221> MOD_RES 
<222> (53)..(53) 
<223> -COOH 
<400> 262 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Arg Arg Arg Arg Arg Arg 35 40 45 
Arg Arg Arg Arg Arg 50 
<210> 263 
<211> 43 
<212> PRT 
<213> Artificial sequence 
Page 158 
<220> 
<223> Variant NV1D3523 
<220> 
<221> MOD_RES 
<222> (43)..(43) 
<223> -COOH 
<400> 263 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 35 40 
<210> 264 
<211> 53 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3524 
<220> 
<221> MOD_RES 
<222> (53)..(53) 
<223> -COOH 
<400> 264 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Tyr Gly Arg Lys Lys Arg 35 40 45 
Arg Gln Arg Arg Arg 50 
<210> 265 
<211> 48 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3525 
Page 159 <220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 265 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 35 40 45 
<210> 266 
<211> 43 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3526 
<220> 
<221> MOD_RES 
<222> (43)..(43) 
<223> -COOH 
<400> 266 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 35 40 
<210> 267 
<211> 42 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3527 
<220> 
<221> MOD_RES 
<222> (42)..(42) 
<223> -COOH 
<400> 	267 Page 160 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 35 40 
<210> 268 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3528 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 268 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala 35 
<210> 269 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3529 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 269 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 Page 161 
<210> 270 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3530 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 270 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 271 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3531 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 271 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 272 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3532 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 162 
<400> 272 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 273 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3533 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 273 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 274 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3534 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 274 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 275 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 163 <220> 
<223> Variant NV1D3535 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 275 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 276 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3536 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 276 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 277 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3537 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 277 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Lys Arg Lys 1 5 10 15 
Page 164 Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 30 
<210> 278 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3538 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 278 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 279 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3539 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 279 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 280 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3540 
<220> Page 165 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 280 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 281 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3541 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 281 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 282 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3542 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 282 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 	283 Page 166 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3543 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 283 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 284 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3544 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 284 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 285 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3545 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 285 
Page 167 
JBI5038WOPCTseqlist_ST25 Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 
20 25 	30 
<210> 286 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3546 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 286 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 287 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3547 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 

<400> 287 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 288 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3548 Page 168 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 288 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 289 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3549 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 289 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 290 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3550 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 290 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 Page 169 
<210> 291 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3551 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 291 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 292 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3552 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 292 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 293 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3553 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 170 
<400> 293 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 294 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3554 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 294 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
<210> 295 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3555 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 295 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 296 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 171 <220> 
<223> Variant NV1D3556 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 296 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 297 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3558 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 297 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 298 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3559 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 298 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Page 172 Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 30 
<210> 299 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3560 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 299 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 300 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3561 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 300 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 301 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> variant NV1D3562 
<220> Page 173 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 301 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 302 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3563 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 302 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 303 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3564 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 303 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	304 Page 174 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3565 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 304 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 305 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3566 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 305 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 306 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3568 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 306 
Page 175 
JBI5038WOPCTseqlist_ST25 Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 	30 
<210> 307 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3569 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 307 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 308 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3570 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 308 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 309 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> 	Variant NV1D3571 Page 176 <220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 309 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 310 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> variant NV1D3572 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 310 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 311 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3573 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 311 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 Page 177 
<210> 312 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3574 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 312 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 313 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3575 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 313 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 314 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3576 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> 	-COOH Page 178 
<400> 314 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 315 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3577 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 315 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 316 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3578 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 316 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 317 
<211> 32 
<212> PRT 
<213> 	Artificial sequence Page 179 <220> 
<223> Variant NV1D3579 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 317 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 318 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3580 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 318 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 319 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3581 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 319 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Page 180 Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
20 25 30 
<210> 320 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3582 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 320 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 321 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3583 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 321 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Arg Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 322 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3584 
<220> Page 181 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 322 
Gly Pro Arg Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 323 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3585 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 323 
Gly Pro Ser Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 324 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3586 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 324 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 	325 Page 182 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3586-NH2 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -NH2 
<400> 325 
Gly Pro Tyr Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 326 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3587 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 326 
Gly Pro Ala Cys Gln Lys Trp Met Gln Thr Cys Asp Ala Asn Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Ser Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 20 25 30 
<210> 327 
<211> 48 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3772 
<220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 327 
Page 183 
JBI5038WOPCTseqlist_ST25 Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His Thr Gly 
35  
<210>  328  
<211>  68  
<212>  PRT  
<213>  Artificial sequence  
<220>  
<223>  Variant NV1D3774  
<220>  
<221>  MOD_RES  
<222>  (68)..(68)  
<223>  -COOH  
<400>  328  

40 45 
Gly Pro Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His 1 5 10 15 
Thr Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Ala Pro Ala Pro Ala Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp 35 40 45 
Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg 
50 55 
Lys Lys Leu Trp 65 
<210> 329 
<211> 58 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3775 
<220> 
<221> MOD_RES 
<222> (58)..(58) 
<223> -COOH 
<400> 329 
60 
Page 184 
Gly Pro Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His 1 5 10 15 
Thr Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gln Cys Gln Lys 20 25 30 
Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val 35 40 45 
Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 50 55 
<210> 330 
<211> 48 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3777 
<220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 330 
Gly Pro Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His 1 5 10 15 
Thr Gly Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 20 25 30 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 45 
<210> 331 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3782 
<220> 
<221> MOD_RES 
<222> (32)..(32) 
<223> -COOH 
<400> 331 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Page 185 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Ala Trp 
20 25 	30 
<210> 332 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3788 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 332 
Gly Pro Ala Ala Ala Ala Ala Gln Cys Gln Lys Trp Met Gln Thr Cys 1 5 10 15 
Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys 20 25 30 
Arg Lys Lys Leu Trp 35 
<210> 333 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3789 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 333 
Gly Pro Ala Pro Ala Pro Ala Gln Cys Gln Lys Trp Met Gln Thr Cys 1 5 10 15 
Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys 20 25 30 
Arg Lys Lys Leu Trp 35 
<210> 	334 Page 186 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3791 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 334 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Ala Ala Ala Ala 35 
<210> 335 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3792 
<220> 
<221> MOD_RES 
<222> (37)..(37) 
<223> -COOH 
<400> 335 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Gly Gly Gly Gly 35 
<210> 336 
<211> 74 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3793 
Page 187 
<220> 
<221> MOD_RES 
<222> (74)..(74) 
<223> -COOH 
<400> 336 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Arg Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Gln Cys Gln Lys 35 40 45 
Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val 50 55 60 
Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 65 70 
<210> 337 
<211> 72 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3795 
<220> 
<221> MOD_RES 
<222> (72)..(72) 
<223> -COOH 
<400> 337 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 
Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Gln Cys Gln Lys Trp Met 35 40 45 
Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr 50 55 60 
Leu Trp Cys Arg Lys Lys Leu Trp 65 70 
Page 188 
<210> 338 
<211> 62 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3796 
<220> 
<221> MOD_RES 
<222> (62)..(62) 
<223> -COOH 
<400> 338 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser 20 25 30 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys 35 40 45 
Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 50 55 60 
<210> 339 
<211> 72 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3797 
<220> 
<221> MOD_RES 
<222> (72)..(72) 
<223> -COOH 
<400> 339 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp 50 55 60 Page 189 
Cys Arg Asp His Ser Arg Cys Cys 
65 70 
<210> 340 
<211> 74 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3798 
<220> 
<221> MOD_RES 
<222> (74)..(74) 
<223> -COOH 
<400> 340 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp 50 55 60 
Cys Arg Asp His Ser Arg Cys Cys Gly Arg 65 70 
<210> 341 
<211> 62 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3799 
<220> 
<221> MOD_RES 
<222> (62)..(62) 
<223> -COOH 
<400> 341 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp Page 190 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys 35 40 45 
Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg Cys Cys 50 55 60 
<210> 342 
<211> 64 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3800 
<220> 
<221> MOD_RES 
<222> (64)..(64) 
<223> -COOH 
<400> 342 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Cys Cys 35 40 45 
Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg Cys Cys Gly Arg 50 55 60 
<210> 343 
<211> 49 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3801 
<220> 
<221> MOD_RES 
<222> (49)..(49) 
<223> -COOH 
<400> 343 
Gly Pro Ser Pro Gly Ala Arg Ala Phe Ala Pro Ala Pro Ala Pro Ala 1 5 10 15 
Page 191 
JBI5038WOPCTseqlist_ST25 Pro Ala Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg 20 25 30 
Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu 
35  
Trp  
<210>  344  
<211>  44  
<212>  PRT  
<213>  Artificial sequence  
<220>  
<223>  Variant NV1D3802  
<220>  
<221>  MOD_RES  
<222>  (44)..(44)  
<223>  -COOH  
<400>  344  

40 45 
Gly Pro Ser Pro Gly Ala Arg Ala Phe Ala Pro Ala Pro Ala Gln Cys 1 5 10 15 
Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly 20 25 30 
Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 345 
<211> 39 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3803 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 345 
Gly Pro Ser Pro Gly Ala Arg Ala Phe Gln Cys Gln Lys Trp Met Gln 1 5 10 15 
Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu 20 25 30 
Page 192 
Trp Cys Arg Lys Lys Leu Trp 35 
<210> 346 
<211> 49 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3804 
<220> 
<221> MOD_RES 
<222> (49)..(49) 
<223> -COOH 
<400> 346 
Gly Pro Asp Gly Pro Trp Arg Lys Met Ala Pro Ala Pro Ala Pro Ala 1 5 10 15 
Pro Ala Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg 20 25 30 
Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu 35 40 45 
Trp 
<210> 347 
<211> 44 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3805 
<220> 
<221> MOD_RES 
<222> (44)..(44) 
<223> -COOH 
<400> 347 
Gly Pro Asp Gly Pro Trp Arg Lys Met Ala Pro Ala Pro Ala Gln Cys 1 5 10 15 
Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly 20 25 30 
Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 Page 193 
<210> 348 
<211> 39 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3806 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 348 
Gly Pro Asp Gly Pro Trp Arg Lys Met Gln Cys Gln Lys Trp Met Gln 1 5 10 15 
Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu 20 25 30 
Trp Cys Arg Lys Lys Leu Trp 35 
<210> 349 
<211> 44 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3808 
<220> 
<221> MOD_RES 
<222> (44)..(44) 
<223> -COOH 
<400> 349 
Gly Pro Phe Gly Gln Lys Ala Ser Ser Ala Pro Ala Pro Ala Gln Cys 1 5 10 15 
Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly 20 25 30 
Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 350 
<211> 39 
<212> PRT 
<213> Artificial sequence 
Page 194 
<220> 
<223> Variant NV1D3809 
<220> 
<221> MOD_RES 
<222> (39)..(39) 
<223> -COOH 
<400> 350 
Gly Pro Phe Gly Gln Lys Ala Ser Ser Gln Cys Gln Lys Trp Met Gln 1 5 10 15 
Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu 20 25 30 
Trp Cys Arg Lys Lys Leu Trp 35 
<210> 351 
<211> 58 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3810 
<220> 
<221> MOD_RES 
<222> (58)..(58) 
<223> -COOH 
<400> 351 
Gly Pro Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala 1 5 10 15 
Asn Gly Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gln Cys Gln Lys 20 25 30 
Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val 35 40 45 
Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 50 55 
<210> 352 
<211> 53 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3811 
Page 195 
<220> 
<221> MOD_RES 
<222> (53)..(53) 
<223> -COOH 
<400> 352 
Gly Pro Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala 1 5 10 15 

Asn Gly Ala Pro Ala Pro Ala Gln Cys Gln Lys Trp Met Gln Thr Cys 20 25 30 
Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys 35 40 45 
Arg Lys Lys Leu Trp 50 
<210> 353 
<211> 48 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3812 
<220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 353 
Gly Pro Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala 1 5 10 15 
Asn Gly Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 20 25 30 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 45 
<210> 354 
<211> 53 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3813 
<220> 
<221> 	MOD_RES Page 196 
<222> (53)..(53) 
<223> -COOH 
<400> 354 
Gly Pro Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ala Pro Ala 1 5 10 15 
Pro Ala Pro Ala Pro Ala Pro Gln Cys Gln Lys Trp Met Gln Thr Cys 20 25 30 
Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys 35 40 45 
Arg Lys Lys Leu Trp 50 
<210> 355 
<211> 48 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3814 
<220> 
<221> MOD_RES 
<222> (48)..(48) 
<223> -COOH 
<400> 355 
Gly Pro Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ala Pro Ala 1 5 10 15 
Pro Ala Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 20 25 30 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 45 
<210> 356 
<211> 43 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3815 
<220> 
<221> MOD_RES 
<222> (43)..(43) 
<223> -COOH 
Page 197 
<400> 356 
Gly Pro Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gln Cys Gln 1 5 10 15 
Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe 20 25 30 
Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 357 
<211> 43 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3818 
<220> 
<221> MOD_RES 
<222> (43)..(43) 
<223> -COOH 
<400> 357 
Gly Pro Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gln Cys Gln 1 5 10 15 
Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe 20 25 30 
Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 358 
<211> 42 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3819 
<220> 
<221> MOD_RES 
<222> (42)..(42) 
<223> -COOH 
<400> 358 
Gly Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gln Cys Gln Lys 1 5 10 15 
Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Page 198 
Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 359 
<211> 107 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3822 
<220> 
<221> MOD_RES 
<222> (107)..(107) 
<223> -COOH 
<400> 359 
Gly Pro Gly Trp Cys Gly Asp Pro Gly Ala Thr Cys Gly Lys Leu Arg 1 5 10 15 
Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ser Tyr Thr Lys Thr Cys Lys 20 25 30 
Asp Lys Ser Ser Ala Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 50 55 60 
Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser Gln Cys Gln 65 70 75 80 
Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe 85 90 95 
Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 100 105 
<210> 360 
<211> 107 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3823 
<220> 
<221> MOD_RES 
<222> 	(107)..(107) Page 199 
<223> -COOH 
<400> 360 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 35 40 45 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 50 55 60 
Pro Ala Pro Gly Gly Gly Gly Ser Gly Trp Cys Gly Asp Pro Gly Ala 65 70 75 80 
Thr Cys Gly Lys Leu Arg Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ser 85 90 95 
Tyr Thr Lys Thr Cys Lys Asp Lys Ser Ser Ala 100 105 
<210> 361 
<211> 107 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3824 
<220> 
<221> MOD_RES 
<222> (107)..(107) 
<223> -COOH 
<400> 361 
Gly Pro Gly Trp Cys Gly Asp Pro Gly Ala Thr Cys Gly Lys Leu Arg 1 5 10 15 
Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ala Tyr Thr Lys Thr Cys Lys 20 25 30 
Asp Lys Ser Ser Ala Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 50 55 60 
Page 200 
Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser Gln Cys Gln 65 70 75 80 
Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe 85 90 95 
Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 100 105 
<210> 362 
<211> 107 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3825 
<220> 
<221> MOD_RES 
<222> (107)..(107) 
<223> -COOH 
<400> 362 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 35 40 45 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 50 55 60 
Pro Ala Pro Gly Gly Gly Gly Ser Gly Trp Cys Gly Asp Pro Gly Ala 65 70 75 80 
Thr Cys Gly Lys Leu Arg Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ala 85 90 95 
Tyr Thr Lys Thr Cys Lys Asp Lys Ser Ser Ala 100 105 
<210> 363 
<211> 107 
<212> PRT 
<213> Artificial sequence 
<220> Page 201 
<223> Variant NV1D3826 
<220> 
<221> MOD_RES 
<222> (107)..(107) 
<223> -COOH 
<400> 363 
Gly Pro Gly Trp Cys Gly Asp Pro Gly Ala Thr Cys Gly Lys Leu Arg 1 5 10 15 
Leu Tyr Cys Cys Ser Gly Phe Cys Asp Cys Tyr Thr Lys Thr Cys Lys 20 25 30 
Asp Lys Ser Ser Ala Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro 35 40 45 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 50 55 60 
Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser Gln Cys Gln 65 70 75 80 
Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe 85 90 95 
Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 100 105 
<210> 364 
<211> 84 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3828 
<220> 
<221> MOD_RES 
<222> (84)..(84) 
<223> -COOH 
<400> 364 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Page 202 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser 50 55 60 
Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 65 70 75 80 
Cys Cys Gly Arg 
<210> 365 
<211> 82 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3829 
<220> 
<221> MOD_RES 
<222> (82)..(82) 
<223> -COOH 
<400> 365 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala 35 40 45 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser 50 55 60 
Gly Ser Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 65 70 75 80 
Cys Cys 
<210> 366 
<211> 84 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3830 
Page 203 
<220> 
<221> MOD_RES 
<222> (84)..(84) 
<223> -COOH 
<400> 366 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys Gly Arg Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala 20 25 30 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly 35 40 45 
Gly Gly Gly Ser Gly Ser Gln Cys Gln Lys Trp Met Gln Thr Cys Asp 50 55 60 
Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg 65 70 75 80 
Lys Lys Leu Trp 
<210> 367 
<211> 61 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3832 
<220> 
<221> MOD_RES 
<222> (61)..(61) 
<223> -COOH 
<400> 367 
Gly Pro Cys Arg Thr Ile Gly Pro Ser Val Cys Ala Pro Ala Pro Ala 1 5 10 15 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gln 20 25 30 
Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu 35 40 45 
Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 50 55 60 
Page 204 <210> 368 
<211> 51 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3833 
<220> 
<221> MOD_RES 
<222> (51)..(51) 
<223> -COOH 
<400> 368 
Gly Pro Cys Arg Thr Ile Gly Pro Ser Val Cys Ala Pro Ala Pro Ala 1 5 10 15 
Pro Ala Pro Ala Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg 20 25 30 
Glu Arg Lys Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys 35 40 45 
Lys Leu Trp 50 
<210> 369 
<211> 46 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3834 
<220> 
<221> MOD_RES 
<222> (46)..(46) 
<223> -COOH 
<400> 369 
Gly Pro Cys Arg Thr Ile Gly Pro Ser Val Cys Ala Pro Ala Pro Ala 1 5 10 15 
Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys 20 25 30 
Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 45 
<210> 370 
<211> 	41 Page 205 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3835 
<220> 
<221> MOD_RES 
<222> (41)..(41) 
<223> -COOH 
<400> 370 
Gly Pro Cys Arg Thr Ile Gly Pro Ser Val Cys Gln Cys Gln Lys Trp 1 5 10 15 
Met Gln Thr Cys Asp Arg Glu Arg Lys Cys Cys Glu Gly Phe Val Cys 20 25 30 
Thr Leu Trp Cys Arg Lys Lys Leu Trp 35 40 
<210> 371 
<211> 46 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Variant NV1D3838 
<220> 
<221> MOD_RES 
<222> (46)..(46) 
<223> -COOH 
<400> 371 
Gly Pro Gln Cys Gln Lys Trp Met Gln Thr Cys Asp Arg Glu Arg Lys 1 5 10 15 
Cys Cys Glu Gly Phe Val Cys Thr Leu Trp Cys Arg Lys Lys Leu Trp 20 25 30 
Ala Pro Ala Pro Ala Cys Arg Thr Ile Gly Pro Ser Val Cys 35 40 45 
<210> 372 
<211> 7 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 	372 Page 206 Gly Pro Ala Ala Ala Ala Ala 
1 5 
<210> 373 
<211> 7 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 373 
Gly Pro Ala Pro Ala Pro Ala 1 5 
<210> 374 
<211> 6 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 374 
Gly Gly Gly Gly Gly Gly 1 5 
<210> 375 
<211> 18 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 375 
Gly Pro Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg 1 5 10 15 
Cys Cys 
<210> 376 
<211> 9 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 376 
Gly Pro Ser Pro Gly Ala Arg Ala Phe 1 5 
Page 207 <210> 377 
<211> 9 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 377 
Gly Pro Asp Gly Pro Trp Arg Lys Met 1 5 
<210> 378 
<211> 9 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 378 
Gly Pro Phe Gly Gln Lys Ala Ser Ser 1 5 
<210> 379 
<211> 11 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 379 
Gly Pro Cys Arg Thr Ile Gly Pro Ser Val Cys 1 5 10 
<210> 380 
<211> 18 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 380 
Gly Pro Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His 1 5 10 15 
Thr Gly 
<210> 	381 Page 208 
<211> 18 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 381 
Gly Pro Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala 1 5 10 15 
Asn Gly 
<210> 382 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 382 
Gly Pro Gly Trp Cys Gly Asp Pro Gly Ala Thr Cys Gly Lys Leu Arg 1 5 10 15 
Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ser Tyr Thr Lys Thr Cys Lys 20 25 30 
Asp Lys Ser Ser Ala 35 
<210> 383 
<211> 10 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 383 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 1 5 10 
<210> 384 
<211> 13 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 384 
Page 209 
1 5 	10 
<210> 385 
<211> 13 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> N-terminal extension 
<400> 385 
Gly Pro Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 1 5 10 
<210> 386 
<211> 9 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 386 
Cys Arg Thr Ile Gly Pro Ser Val Cys 1 5 
<210> 387 
<211> 11 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 387 
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 
<210> 388 
<211> 7 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 388 
Asp Gly Pro Trp Arg Lys Met 1 5 
<210> 389 
<211> 16 
<212> 	PRT Page 210 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 389 
Cys Cys Asn Cys Ser Ser Lys Trp Cys Arg Asp His Ser Arg Cys Cys 1 5 10 15 
<210> 390 
<211> 11 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 390 
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 1 5 10 
<210> 391 
<211> 16 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 391 
Ser His Ser Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His Thr Gly 1 5 10 15 
<210> 392 
<211> 5 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 392 
Ala Pro Ala Pro Ala 1 5 
<210> 393 
<211> 5 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 393 
Page 211 
1 5 
<210> 394 
<211> 7 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 394 
Phe Gly Gln Lys Ala Ser Ser 1 5 
<210> 395 
<211> 16 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 395 
Gln Arg Phe Val Thr Gly His Phe Gly Gly Leu Tyr Pro Ala Asn Gly 1 5 10 15 
<210> 396 
<211> 7 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 396 
Ser Pro Gly Ala Arg Ala Phe 1 5 
<210> 397 
<211> 37 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> C-terminal extension 
<400> 397 
Gly Pro Gly Trp Cys Gly Asp Pro Gly Ala Thr Cys Gly Lys Leu Arg 1 5 10 15 
Leu Tyr Cys Cys Ser Gly Phe Cys Asp Ala Tyr Thr Lys Thr Cys Lys 20 25 30 
Page 212 
Asp Lys Ser Ser Ala 
35 
<210> 398 
<211> 14 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Linker 
<400> 398 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser 1 5 10 
<210> 399 
<211> 24 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Linker 
<400> 399 
Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 1 5 10 15 
Ala Pro Ala Pro Ala Pro Gly Ser 20 
<210> 400 
<211> 40 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Linker 
<400> 400 
Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 1 5 10 15 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 20 25 30 
Pro Ala Pro Gly Gly Gly Gly Ser 35 40 
<210> 401 
<211> 34 
<212> PRT 
<213> 	Artificial sequence Page 213 <220> 
<223> Linker 
<400> 401 
Gly Ser Gly Gly Gly Gly Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala 1 5 10 15 
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Gly Gly Gly Ser 20 25 30 
Gly Ser 
<210> 402 
<211> 20 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Linker 
<400> 402 
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 1 5 10 15 
Ala Pro Ala Pro 20 
<210> 403 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Genus protoxin-II sequence 
<220> 
<221> MISC_FEATURE 
<222> (1)..(1) 
<223> Xaa is Gly, Pro, Ala or deleted 
<220> 
<221> MISC_FEATURE 
<222> (2)..(2) 
<223> Xaa is Pro, Ala or deleted 
<220> 
<221> MISC_FEATURE 
<222> (3)..(3) 
<223> Xaa is Ser, Qln, Ala, Arg or Tyr 
<220> 
<221> MISC_FEATURE 
<222> 	(5)..(5) Page 214 
JBI5038WOPCTseqlist_ST25  
<223>  Xaa is Qln, Arg, Lys, Ala or Ser  
<220>  
<221>  MISC_FEATURE  
<222>  (6)..(6)  
<223>  Xaa is  Lys, Ser, Qln or Arg  
<220>  
<221>  MISC_FEATURE  
<222>  (8)..(8)  
<223>  Xaa is  Met or Phe  
<220>  
<221>  MISC_FEATURE  
<222>  (10)..(10)  
<223>  Xaa is  Thr, Ser, Arg, Lys or Qln  
<220>  
<221>  MISC_FEATURE  
<222>  (12)..(12)  
<223>  Xaa is  Asp or Thr  
<220>  
<221>  MISC_FEATURE  
<222>  (13)..(13)  
<223>  Xaa is Ser, Ala or Arg  
<220>  
<221>  MISC_FEATURE  
<222>  (14)..(14)  
<223>  Xaa is Glu, Arg, Asn, Lys, Thr or Qln  
<220>  
<221>  MISC_FEATURE  
<222>  (15)..(15)  
<223>  Xaa is Arg or Lys  
<220>  
<221>  MISC_FEATURE  
<222>  (16)..(16)  
<223>  Xaa is Lys, Qln, Ser or Ala  
<220>  
<221>  MISC_FEATURE  
<222>  (19)..(19)  
<223>  Xaa is Glu, Qln or Asp  
<220>  
<221>  MISC_FEATURE  
<222>  (20)..(20)  
<223>  Xaa is Glu or Qln  
<220>  
<221>  MISC_FEATURE  
<222>  (22)..(22)  
<223>  Xaa is Val or Ser  
<220>  
<221>  MISC_FEATURE  
<222>  (24)..(24)  
<223>  Xaa is Arg or Thr  
<220>  
Page 215  

<221> MISC_FEATURE 
<222> (28)..(28) 
<223> Xaa is Lys or Arg 
<400> 403 
Xaa Xaa Xaa Cys Xaa Xaa Trp Xaa Gln Xaa Cys Xaa Xaa Xaa Xaa Xaa 1 5 10 15 
Cys Cys Xaa Xaa Phe Xaa Cys Xaa Leu Trp Cys Xaa Lys Lys Leu Trp 20 25 30 
<210> 404 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Protoxin-II genus 2 
<220> 
<221> MISC_FEATURE 
<222> (5)..(5) 
<223> Xaa is Qln, Arg, Lys, Ala or Ser 
<220> 
<221> MISC_FEATURE 
<222> (6)..(6) 
<223> Xaa is Lys, Ser, Qln or Arg 
<220> 
<221> MISC_FEATURE 
<222> (8)..(8) 
<223> Xaa is Met or Phe 
<220> 
<221> MISC_FEATURE 
<222> (10)..(10) 
<223> Xaa is Thr, Ser, Arg, Lys or Qln 
<220> 
<221> MISC_FEATURE 
<222> (12)..(12) 
<223> Xaa is Asp or Thr 
<220> 
<221> MISC_FEATURE 
<222> (13)..(13) 
<223> Xaa is Ser, Ala or Arg 
<220> 
<221> MISC_FEATURE 
<222> (14)..(14) 
<223> Xaa is Glu, Arg, Asn, Lys, Thr or Qln 
<220> 
<221> MISC_FEATURE 
<222> (15)..(15) 
<223> Xaa is Arg or Lys 
Page 216 
<220> 
<221> MISC_FEATURE 
<222> (16)..(16) 
<223> Xaa is Lys, Qln, Ser or Ala 
<220> 
<221> MISC_FEATURE 
<222> (19)..(19) 
<223> Xaa is Glu, Qln or Asp 
<220> 
<221> MISC_FEATURE 
<222> (20)..(20) 
<223> Xaa is is Gly or Qln 
<220> 
<221> MISC_FEATURE 
<222> (22)..(22) 
<223> Xaa is Val or Ser 
<220> 
<221> MISC_FEATURE 
<222> (24)..(24) 
<223> Xaa is Arg or Thr 
<220> 
<221> MISC_FEATURE 
<222> (28)..(28) 
<223> Xaa is Lys or Arg 
<400> 404 
Gly Pro Gln Cys Xaa Xaa Trp Xaa Gln Xaa Cys Xaa Xaa Xaa Xaa Xaa 1 5 10 15 
Cys Cys Xaa Xaa Phe Xaa Cys Xaa Leu Trp Cys Xaa Lys Lys Leu Trp 20 25 30 
<210> 405 
<211> 32 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> Protoxin-II genus 3 
<220> 
<221> MISC_FEATURE 
<222> (3)..(3) 
<223> Xaa is Tyr, Qln, Ala, Ser or Arg 
<220> 
<221> MISC_FEATURE 
<222> (10)..(10) 
<223> Xaa is Thr or Ser 
<220> 
<221> MISC_FEATURE 
<222> (13)..(13) 
<223> 	Xaa is Ser, Arg or Ala Page 217 <220> 
<221> MISC_FEATURE 
<222> (14)..(14) 
<223> Xaa is Glu, Thr or Asn 
<220> 
<221> MISC_FEATURE 
<222> (19)..(19) 
<223> Xaa is Glu or Qln 
<220> 
<221> MISC_FEATURE 
<222> (22)..(22) 
<223> Xaa is Val or Ser 
<220> 
<221> MISC_FEATURE 
<222> (24)..(24) 
<223> Xaa is Arg or Thr 
<220> 
<221> MISC_FEATURE 
<222> (28)..(28) 
<223> Xaa is Lys or Arg 
<400> 405 
Gly Pro Xaa Cys Gln Lys Trp Met Gln Xaa Cys Asp Xaa Xaa Arg Lys 1 5 10 15 
Cys Cys Xaa Gly Phe Xaa Cys Xaa Leu Trp Cys Xaa Lys Lys Leu Trp 20 25 30 
<210> <211> <212> <213>  406 32 PRT Artificial sequence  
<220> <223>  Protoxin-II genus 4  
<220> <221> <222> <223>  MISC_FEATURE (10)..(10) Xaa is Thr or Ser  
<220> <221> <222> <223>  MISC_FEATURE (13)..(13) Xaa is Ser, Arg or Ala  
<220> <221> <222> <223>  MISC_FEATURE (14)..(14) Xaa is Glu, Thr or Asn  
<220> <221> <222>  MISC_FEATURE (19)..(19)  Page 218  

<223> Xaa is Glu or Qln 
<220> 
<221> MISC_FEATURE 
<222> (22)..(22) 
<223> Xaa is Val or Ser 
<220> 
<221> MISC_FEATURE 
<222> (24)..(24) 
<223> Xaa is Arg or Thr 
<220> 
<221> MISC_FEATURE 
<222> (28)..(28) 
<223> Xaa is Lys or Arg 
<400> 406 
Gly Pro Gln Cys Gln Lys Trp Met Gln Xaa Cys Asp Xaa Xaa Arg Lys 1 5 10 15 
Cys Cys Xaa Gly Phe Xaa Cys Xaa Leu Trp Cys Xaa Lys Lys Leu Trp 20 25 30 
<210> 407 
<211> 1980 
<212> PRT 
<213> Homo sapiens 
<400> 407 
Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 1 5 10 15 
Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 20 25 30 
Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 35 40 45 
Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 50 55 60 
Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 65 70 75 80 
Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 85 90 95 
Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 100 105 110 
Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile Page 219 
Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 130 135 140 
Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 145 150 155 160 
Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 165 170 175 
Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 180 185 190 
Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 195 200 205 
Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 210 215 220 
Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 225 230 235 240 
Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 245 250 255 
Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 260 265 270 
Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 275 280 285 
Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 290 295 300 
Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 305 310 315 320 
Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 325 330 335 
Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 340 345 350 
Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 355 360 365 
Page 220 
JBI5038WOPCTseqlist_ST25 Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 370 375 380 
Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 385 390 395 400 
Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 405 410 415 
Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 420 425 430 
Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 435 440 445 
Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 450 455 460 
Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 465 470 475 480 
Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 485 490 495 
Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 500 505 510 
Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 515 520 525 
Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 530 535 540 
Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 545 550 555 560 
Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 565 570 575 
Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 580 585 590 
Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 595 600 605 
Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 610 615 620 
Page 221 
Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 625 630 635 640 
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 645 650 655 
Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 660 665 670 
Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 675 680 685 
Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 690 695 700 
Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 705 710 715 720 
Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 725 730 735 
Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 740 745 750 
Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 755 760 765 
Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 770 775 780 
Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 785 790 795 800 
Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 805 810 815 
Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 820 825 830 
Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 835 840 845 
Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 850 855 860 
Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 865 870 875 880 
Page 222 
Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 885 890 895 
Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 900 905 910 
Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 915 920 925 
Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 930 935 940 
Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 945 950 955 960 
Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 965 970 975 
Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 980 985 990 
Glu Met Asn Asn Leu Gln Ile Ser Val Ile Arg Ile Lys Lys Gly Val 995 1000 1005 
Ala Trp Thr Lys Leu Lys Val 1010 1015 
Lys Gln Arg Glu Ala Asp Glu 1025 1030 
Glu Lys Lys Ala Asn Cys Ile 1040 1045 
His Arg Asn Gly Asp Phe Gln 1055 1060 
Gly Ile Gly Ser Ser Val Glu 1070 1075 
Met Ser Phe Ile Asn Asn Pro 1085 1090 
Ala Val Gly Glu Ser Asp Phe 1100 1105 
His Ala Phe Met Gln 1020 
Val Lys Pro Leu Asp 1035 
Ala Asn His Thr Gly 1050 
Lys Asn Gly Asn Gly 1065 
Lys Tyr Ile Ile Asp 1080 
Asn Leu Thr Val Arg 1095 
Glu Asn Leu Asn Thr 1110 
Ala His Phe 
Glu Leu Tyr 
Ala Asp Ile 
Thr Thr Ser 
Glu Asp His 
Val Pro Ile 
Glu Asp Val 
Ser Ser Glu Ser Asp Pro Glu Gly Ser Lys Asp Lys Leu Asp Asp Page 223 
Thr Ser Ser Ser Glu Gly Ser Thr Ile Asp Ile Lys Pro Glu Val 1130 1135 1140 
Glu Glu Val Pro Val Glu Gln Pro Glu Glu Tyr Leu Asp Pro Asp 1145 1150 1155 
Ala Cys Phe Thr Glu Gly Cys Val Gln Arg Phe Lys Cys Cys Gln 1160 1165 1170 
Val Asn Ile Glu Glu Gly Leu Gly Lys Ser Trp Trp Ile Leu Arg 1175 1180 1185 
Lys Thr Cys Phe Leu Ile Val Glu His Asn Trp Phe Glu Thr Phe 1190 1195 1200 
Ile Ile Phe Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu 1205 1210 1215 
Asp Ile Tyr Ile Glu Gln Arg Lys Thr Ile Arg Thr Ile Leu Glu 1220 1225 1230 
Tyr Ala Asp Lys Val Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu 1235 1240 1245 
Leu Lys Trp Thr Ala Tyr Gly Phe Val Lys Phe Phe Thr Asn Ala 1250 1255 1260 
Trp Cys Trp Leu Asp Phe Leu Ile Val Ala Val Ser Leu Val Ser 1265 1270 1275 
Leu Ile Ala Asn Ala Leu Gly Tyr Ser Glu Leu Gly Ala Ile Lys 1280 1285 1290 
Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser 1295 1300 1305 
Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val Gly Ala 1310 1315 1320 
Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp 1325 1330 1335 
Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Tyr 1340 1345 1350 
Page 224 
His Tyr Cys Phe Asn Glu Thr Ser Glu Ile Arg Phe Glu Ile Glu 1355 1360 1365 
Asp Val Asn Asn Lys Thr Glu Cys Glu Lys Leu Met Glu Gly Asn 1370 1375 1380 
Asn Thr Glu Ile Arg Trp Lys Asn Val Lys Ile Asn Phe Asp Asn 1385 1390 1395 
Val Gly Ala Gly Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe Lys 1400 1405 1410 
Gly Trp Met Asp Ile Met Tyr Ala Ala Val Asp Ser Arg Lys Pro 1415 1420 1425 
Asp Glu Gln Pro Lys Tyr Glu Asp Asn Ile Tyr Met Tyr Ile Tyr 1430 1435 1440 
Phe Val Ile Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu 1445 1450 1455 
Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys 1460 1465 1470 
Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr 1475 1480 1485 
Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro 1490 1495 1500 
Ile Pro Arg Pro Leu Asn Lys Ile Gln Gly Ile Val Phe Asp Phe 1505 1510 1515 
Val Thr Gln Gln Ala Phe Asp Ile Val Ile Met Met Leu Ile Cys 1520 1525 1530 
Leu Asn Met Val Thr Met Met Val Glu Thr Asp Thr Gln Ser Lys 1535 1540 1545 
Gln Met Glu Asn Ile Leu Tyr Trp Ile Asn Leu Val Phe Val Ile 1550 1555 1560 
Phe Phe Thr Cys Glu Cys Val Leu Lys Met Phe Ala Leu Arg His 1565 1570 1575 
Tyr Tyr Phe Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val 1580 1585 1590 
Page 225 
Ile Leu Ser Ile Val Gly Met Phe Leu Ala Asp Ile Ile Glu Lys 1595 1600 1605 
Tyr Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg 1610 1615 1620 
Ile Gly Arg Ile Leu Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg 1625 1630 1635 
Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn 1640 1645 1650 
Ile Gly Leu Leu Leu Phe Leu Val Met Phe Ile Phe Ser Ile Phe 1655 1660 1665 
Gly Met Ser Asn Phe Ala Tyr Val Lys His Glu Ala Gly Ile Asp 1670 1675 1680 
Asp Met Phe Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu 1685 1690 1695 
Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Leu Pro 1700 1705 1710 
Ile Leu Asn Arg Pro Pro Asp Cys Ser Leu Asp Lys Glu His Pro 1715 1720 1725 
Gly Ser Gly Phe Lys Gly Asp Cys Gly Asn Pro Ser Val Gly Ile 1730 1735 1740 
Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Ile Val Val 1745 1750 1755 
Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn Phe Ser Val Ala Thr 1760 1765 1770 
Glu Glu Ser Ala Asp Pro Leu Ser Glu Asp Asp Phe Glu Thr Phe 1775 1780 1785 
Tyr Glu Ile Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile 1790 1795 1800 
Glu Tyr Cys Lys Leu Ala Asp Phe Ala Asp Ala Leu Glu His Pro 1805 1810 1815 
Leu Arg Val Pro Lys Pro Asn Thr Ile Glu Leu Ile Ala Met Asp 1820 1825 1830 Page 226 
Leu Pro Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu 1835 1840 1845 
Phe Ala Phe Thr Lys Arg Val Leu Gly Asp Ser Gly Glu Leu Asp 1850 1855 1860 
Ile Leu Arg Gln Gln Met Glu Glu Arg Phe Val Ala Ser Asn Pro 1865 1870 1875 
Ser Lys Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Arg Arg Lys 1880 1885 1890 
Gln Glu Glu Val Ser Ala Val Val Leu Gln Arg Ala Tyr Arg Gly 1895 1900 1905 
His Leu Ala Arg Arg Gly Phe Ile Cys Lys Lys Thr Thr Ser Asn 1910 1915 1920 
Lys Leu Glu Asn Gly Gly Thr His Arg Glu Lys Lys Glu Ser Thr 1925 1930 1935 
Pro Ser Thr Ala Ser Leu Pro Ser Tyr Asp Ser Val Thr Lys Pro 1940 1945 1950 
Glu Lys Glu Lys Gln Gln Arg Ala Glu Glu Gly Arg Arg Glu Arg 1955 1960 1965 
Ala Lys Arg Gln Lys Glu Val Arg Glu Ser Lys Cys 1970 1975 1980 
Page 227 

