                         SEQUENCE LISTING

<110>  Graham, Vallen
       Thomas, Sakmar
 
<120>  Amyloid Protofibril Antibodies and Methods of Use Thereof

<130>  49248-136049

<150>  61/885,593
<151>  2013-10-02

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  2
<211>  474
<212>  PRT
<213>  Bos taurus

<400>  2

Met Pro Pro Ser Gly Pro Arg Ala Ala Leu Phe Leu Leu Pro Ser Leu 
1               5                   10                  15      


Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly Ala Pro 
            20                  25                  30          


Lys Glu Glu Asn Pro Ala Thr Glu Ser Pro Asp Thr Gly Leu Tyr Tyr 
        35                  40                  45              


His Arg Tyr Leu Gln Glu Val Ile Asn Val Leu Glu Thr Asp Gly His 
    50                  55                  60                  


Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile Lys Ser Gly 
65                  70                  75                  80  


Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val Arg Thr Lys 
                85                  90                  95      


Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg Met Leu Leu 
            100                 105                 110         


Lys Ala Lys Met Asp Ala Gln Gln Glu Pro Asn Ile Gln Leu Asp His 
        115                 120                 125             


Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln Asn Gln His 
    130                 135                 140                 


Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr Ala Thr Arg 
145                 150                 155                 160 


Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe Lys Arg Tyr 
                165                 170                 175     


Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu Ser Leu Gly 
            180                 185                 190         


Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu Gln Gln Arg 
        195                 200                 205             


Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser Gln Ala Gln 
    210                 215                 220                 


Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro Asn Arg Phe 
225                 230                 235                 240 


Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser Asp Gly Val 
                245                 250                 255     


Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu Leu Glu Lys 
            260                 265                 270         


Val Tyr Asp Pro Lys Asn Glu Asp Asp Asp Met Arg Glu Met Glu Glu 
        275                 280                 285             


Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val Asp Thr Asn 
    290                 295                 300                 


Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser Thr Gln Arg 
305                 310                 315                 320 


Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Gln Gly Lys Ala Gly 
                325                 330                 335     


Val Pro Leu Pro Met Ala Pro Val Leu Thr Leu Gln Thr Val Glu Met 
            340                 345                 350         


His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu Glu Leu 
        355                 360                 365             


Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu Ser Gln 
    370                 375                 380                 


Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala Gln Lys 
385                 390                 395                 400 


Arg Glu Leu Gln Gln Ala Val Leu Gln Met Glu Gln Arg Lys Gln Gln 
                405                 410                 415     


Gln Gln Ser His Asn Asn Pro Ala Pro Gly Pro Glu Gly Gln Leu Lys 
            420                 425                 430         


Phe His Pro Asp Thr Asp Asp Val Pro Val Pro Ala Pro Ala Gly Asp 
        435                 440                 445             


Gln Lys Asp Val Asp Ala Ser Glu Lys Lys Val Pro Glu Gln Thr Pro 
    450                 455                 460                 


Glu Pro Pro Gln Leu Asp Ser Gln His Leu 
465                 470                 


<210>  3
<211>  457
<212>  PRT
<213>  Sus scrofa

<400>  3

Met Pro Pro Tyr Gly Thr Leu Thr Ala Leu Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu His Ala Val Leu Ala Val Pro Leu Asp Arg Gly Ala Ser 
            20                  25                  30          


Lys Glu Glu Asn Pro Ala Thr Glu Ser Pro Asp Thr Gly Leu Tyr Tyr 
        35                  40                  45              


His Arg Tyr Leu Gln Glu Val Ile Asn Val Leu Glu Thr Asp Gly His 
    50                  55                  60                  


Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile Lys Ser Gly 
65                  70                  75                  80  


Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val Arg Thr Lys 
                85                  90                  95      


Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg Met Leu Leu 
            100                 105                 110         


Lys Ala Lys Met Asp Ala Glu Gln Glu Pro Asn Val Gln Leu Asp His 
        115                 120                 125             


Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln Asn Gln His 
    130                 135                 140                 


Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr Ala Thr Arg 
145                 150                 155                 160 


Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe Lys Arg Tyr 
                165                 170                 175     


Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu Ser Leu Gly 
            180                 185                 190         


Glu Glu Gln Arg Lys Glu Ala Glu Lys Lys Leu Glu Glu Gln Gln Arg 
        195                 200                 205             


Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser Gln Ala Gln 
    210                 215                 220                 


Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro Asn Arg Phe 
225                 230                 235                 240 


Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser Asp Gly Val 
                245                 250                 255     


Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu Leu Glu Lys 
            260                 265                 270         


Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu Met Glu Glu 
        275                 280                 285             


Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val Asp Thr Asn 
    290                 295                 300                 


Gln Asp Arg Leu Val Thr Leu Asp Glu Phe Leu Ala Ser Thr Gln Arg 
305                 310                 315                 320 


Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val Glu Met His 
                325                 330                 335     


Pro Ala Tyr Thr Glu Asp Glu Leu Arg Arg Phe Glu Glu Glu Leu Ala 
            340                 345                 350         


Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu Ser Gln Glu 
        355                 360                 365             


Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala Gln Lys Arg 
    370                 375                 380                 


Glu Leu Gln Gln Ala Val Leu Gln Met Glu Gln Arg Lys Gln Gln Gln 
385                 390                 395                 400 


Gln Gly His Lys Asp Pro Ala Thr Gly Pro Glu Gly Gln Leu Lys Phe 
                405                 410                 415     


His Pro Asp Thr Asp Asp Ala Pro Val Pro Ala Pro Ala Gly Asp Gln 
            420                 425                 430         


Lys Asp Val Asp Ala Ser Glu Lys Lys Val Pro Glu Gln Thr Pro Glu 
        435                 440                 445             


Leu Pro Gln Leu Asp Ser Gln His Leu 
    450                 455         


<210>  4
<211>  457
<212>  PRT
<213>  Canis familiaris

<400>  4

Met Pro Ser Ser Gly Pro Arg Ala Ala Leu Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly Ala Pro 
            20                  25                  30          


Lys Gln Glu Ser Pro Ala Thr Glu Ser Pro Asp Thr Gly Leu Tyr Tyr 
        35                  40                  45              


His Arg Tyr Leu Gln Glu Val Ile Asn Val Leu Glu Thr Asp Gly His 
    50                  55                  60                  


Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile Lys Ser Gly 
65                  70                  75                  80  


Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val Arg Thr Lys 
                85                  90                  95      


Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg Met Leu Leu 
            100                 105                 110         


Lys Ala Lys Met Asp Ala Glu Gln Glu Pro Asn Val Gln Leu Asp His 
        115                 120                 125             


Leu Ser Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln Asn Gln His 
    130                 135                 140                 


Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr Ala Thr Arg 
145                 150                 155                 160 


Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe Lys Arg Tyr 
                165                 170                 175     


Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu Ser Leu Gly 
            180                 185                 190         


Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu Gln Gln Arg 
        195                 200                 205             


Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser Gln Ala Gln 
    210                 215                 220                 


Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro Asn Arg Phe 
225                 230                 235                 240 


Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser Asp Gly Val 
                245                 250                 255     


Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu Leu Glu Lys 
            260                 265                 270         


Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu Met Glu Glu 
        275                 280                 285             


Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val Asp Thr Asn 
    290                 295                 300                 


Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser Thr Gln Arg 
305                 310                 315                 320 


Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val Glu Met His 
                325                 330                 335     


Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu Glu Leu Ala 
            340                 345                 350         


Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu Ser Gln Glu 
        355                 360                 365             


Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala Gln Lys Arg 
    370                 375                 380                 


Glu Leu Gln Gln Ala Val Leu Gln Met Glu Gln Arg Lys Gln Gln Gln 
385                 390                 395                 400 


Gln Asn Gln Asn Ser Pro Ala Pro Gly Pro Glu Gly Gln Leu Gln Phe 
                405                 410                 415     


His Pro Asp Thr Asp Asp Ala Pro Val Pro Ala Pro Ala Gly Asp Gln 
            420                 425                 430         


Lys Asp Ala Asp Thr Ser Glu Lys Lys Ala Pro Asp Gln Pro Pro Glu 
        435                 440                 445             


Leu Pro Gln Leu Asp Thr Gln His Leu 
    450                 455         


<210>  5
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  5
gggaattcga ggtgcagctg caggagtctg g                                      31


<210>  6
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  6
agggggctct cgcaggagac gagg                                              24


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  7
ggaaggtgtg cacaccgctg gac                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  8
ggaaggtgtg cacaccactg gac                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  9
ggaaggtgtg cacactgctg gac                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  10
agactgtgcg cacaccgctg gac                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  11
gaaagttcac ggtggttata tcc                                               23


<210>  12
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  12
gggaattcga ggtgcagctg caggagtctg g                                      31


<210>  13
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  13
agggggaaga catttgggaa ggac                                              24


<210>  14
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  14
gctcagggaa atagcccttg ac                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  15
gctcagggaa ataacccttg ac                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  16
actcagggaa gtagcccttg ac                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  17
gctcagggaa gtagcctttg ac                                                22


<210>  18
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  18
tgccgaaagg gaagtaatcg tgaat                                             25


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  19
tgctgctgct ctgggttcca g                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  20
attwtcagct tcctgctaat c                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  21
ttttgctttt ctggattyca g                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  22
tcgtgttkct stggttgtct g                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  23
atggaatcac agrcycwggt                                                   20


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  24
tcttgttgct ctggttycca g                                                 21


<210>  25
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  25
cagttcctgg ggctcttgtt gttc                                              24


<210>  26
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  26
ctcactagct cttctcctc                                                    19


<210>  27
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  27
gatggtggga agatggatac agtt                                              24


<210>  28
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  28
gayattgtgm tsacmcarwc tmca                                              24


<210>  29
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  29
gccaccgtac gtttgatttc cagcttggtg                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  30
gccaccgtac gttttatttc cagcttggtc                                        30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  31
gccaccgtac gttttatttc caactttgtc                                        30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  32
gccaccgtac gtttcagctc cagcttggtc                                        30


<210>  33
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  33
caggctgttg tgactcag                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  34
caacttgtgc tcactcag                                                     18


<210>  35
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  35
gtaccatytg ccttccagkc cact                                              24


<210>  36
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  36
caggctgttg tgactcag                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  37
caacttgtgc tcactcag                                                     18


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  38
ctcytcagrg gaaggtggra aca                                               23


<210>  39
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  39
gaggtgcagc tgcaggagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

ccctgcaagg cttctggata cacattcact gactacaaca tggactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactatctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct attactgtgc aagaaagggg      300

gagaggggct ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  40
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  40

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Glu Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  41
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  41
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctctagggga gaaggtcacc       60

atgagctgca gggccagctc aagtgtaaat tacatgtact ggtaccagca gaagtcagat      120

gcctccccca aactatggat ttattacaca tccaacctgg ctcctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gaactcttat tctctcacaa tcagcagcat ggagggtgaa      240

gatgctgcca cttattactg ccagcagttt actagttccc catccacgtt cggtgctggg      300

accaagctgg agctgaaac                                                   319


<210>  42
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  42

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  43
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  43

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  44

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  45
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  45

Ala Arg Lys Gly Glu Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  46
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  46

Ser Ser Val Asn Tyr 
1               5   


<210>  47
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  47

Met Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly 
        35                  40                  45              


Glu Asp Ala Ala Thr Tyr Tyr Cys 
    50                  55      


<210>  48
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Phe Thr Ser Ser Pro Ser Thr 
1               5               


<210>  49
<211>  349
<212>  DNA
<213>  Mus musculus

<400>  49
gaggtgcagc tgcaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gactatggaa tgcactgggt tcgtcaggct      120

ccagagaagg gactggagtg ggttgcatac attagtagtg gcagtagtac cgtctactgt      180

gcagacacag tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgttc      240

ctgcaaatga ccagtctgag gtctgaggac acggccatgt attactgtgc aaggcgctgg      300

ggctactttg actactgggg ccaaggcacc actctcacag tctcctcag                  349


<210>  50
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  50

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Val Tyr Cys Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Trp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  322
<212>  DNA
<213>  Mus musculus

<400>  51
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

ttcacttgca aggcgagtca ggacattaat agctttttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcaccag cctggagttt      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa ac                                               322


<210>  52
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  52

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Thr Ser Leu Glu Phe 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  53
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  53

Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  54

Ile Ser Ser Gly Ser Ser Thr Val 
1               5               


<210>  55
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  55

Ala Arg Arg Trp Gly Tyr Phe Asp Tyr 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Asp Ile Asn Ser Phe 
1               5       


<210>  57
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  57

Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
1               5                   10                  15      


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Thr Ser Leu Glu Phe 
        35                  40                  45              


Glu Asp Met Gly Ile Tyr Tyr Cys 
    50                  55      


<210>  58
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  58

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  59
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  59
gaggtgcagc tgcaggagtc tggacctgtg ctggtgaagc ctggggcttc agtgaagatg       60

tcctgtaagg cttctggata cacattcact gactactata tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagtt attaatcctt acaacggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgttgaca agtcctccag cacagcctac      240

atggagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagacggcga      300

ggctatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc ag              352


<210>  60
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  60

Glu Val Gln Leu Gln Glu Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  322
<212>  DNA
<213>  Mus musculus

<400>  61
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ctccgtacac gttcggaggg      300

gggaccaacc tggaaataaa ac                                               322


<210>  62
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105         


<210>  63
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  63

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  64

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  65
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  65

Ala Arg Arg Arg Gly Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  66
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  66

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  67
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  67

Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
1               5                   10                  15      


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
        35                  40                  45              


Glu Asp Phe Gly Ser Tyr Tyr Cys 
    50                  55      


<210>  68
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  68

His His Tyr Gly Thr Pro Tyr Thr 
1               5               


<210>  69
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  69
gaggtgcagc tgcaggagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt cagcttcaat acctacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

ctgggagcta tggactactg gggtcaagga acctcagtca ccgtctcctc ag              352


<210>  70
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  70

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Leu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  322
<212>  DNA
<213>  Mus musculus

<400>  71
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atccgctcac gttcggtgct      300

gggaccaagc tggagctgaa ac                                               322


<210>  72
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  72

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105     


<210>  73
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  73

Gly Phe Ser Phe Asn Thr Tyr Ala 
1               5               


<210>  74
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  74

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  75
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  75

Val Arg Leu Gly Ala Met Asp Tyr 
1               5               


<210>  76
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  76

Gln Asn Val Gly Thr Asn 
1               5       


<210>  77
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  77

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
1               5                   10                  15      


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
            20                  25                  30          


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
        35                  40                  45              


Glu Asp Leu Ala Glu Tyr Phe Cys 
    50                  55      


<210>  78
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  78

Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5               


<210>  79
<211>  358
<212>  DNA
<213>  Mus musculus

<400>  79
gaggtgcagc tgcaggagtc tggacctgtg ctggtgaagc ctggggcttc agtgaagatg       60

tcctgtaagg cttctggata cacattcact gactactata tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagtt attaatcctt acaacggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgttgaca agtcctccag cacagcctac      240

atggagctca acagcctgac atctgaggac tctgcagtct attactgtgc atctttacga      300

cgccggactg actactttga ctactggggc caaggcacca ctctcacagt ctcctcag        358


<210>  80
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  80

Glu Val Gln Leu Gln Glu Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Arg Arg Arg Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  81
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  81
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  82
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  82

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  83
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  83

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  84

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  85
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  85

Ala Ser Leu Arg Arg Arg Thr Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  86
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  86

Gln Asp Val Gly Thr Ala 
1               5       


<210>  87
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  87

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
            20                  25                  30          


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
        35                  40                  45              


Glu Asp Leu Ala Asp Tyr Phe Cys 
    50                  55      


<210>  88
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  88

Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5               


<210>  89
<211>  355
<212>  DNA
<213>  Mus musculus

<400>  89
gaggtgcagc tgcaggagtc tggcgctgag ttggtgaaac ctggagcttc agtgaagata       60

tcctgcaagg tttctggcta caccttcact gaccatacta ttcactggat gaagcagagg      120

cctgaacagg gcctggaatg gattggatat atttatccta gagatggtag tactaagtac      180

aatgagaagt tcaagggcaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct atttctgtgc aagaccgtat      300

gattacgcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tgcag           355


<210>  90
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  90

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Thr Ile His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Asp Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  91
<211>  322
<212>  DNA
<213>  Mus musculus

<400>  91
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccattcac gttcggctcg      300

gggacaaagt tggaaataaa ac                                               322


<210>  92
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  92

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  93

Gly Tyr Thr Phe Thr Asp His Thr 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  94

Ile Tyr Pro Arg Asp Gly Ser Thr 
1               5               


<210>  95
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  95

Ala Arg Pro Tyr Asp Tyr Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  96
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  96

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  97
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  97

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
        35                  40                  45              


Glu Asp Ile Ala Asp Tyr Tyr Cys 
    50                  55      


<210>  98
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  98

Gln Ser Asn Ser Trp Pro Phe Thr 
1               5               


<210>  99
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10                  15      


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
            20                  25                  30          


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40              


<210>  100
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  101
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  102
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Cys Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


