
                                SEQUENCE LISTING

<110> Dana-Farber Cancer Institute, Inc.

<120> Methods of Treating Cancer with
  Atovaquone-Related Compounds

<130> 00530-0314WO1

<150> US 61/885,164       
<151> 2013-10-01  

<160> 58

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1752
<212> DNA
<213> Homo sapiens

<400> 1
agggcgcagc aggccaaggg ggaggtgcga gcgtggacct gggacgggtc tgggcggctc 60
tcggtggttg gcacgggttc gcacacccat tcaagcggca ggacgcactt gtcttagcag 120
ttctcgctga ccgcgctagc tgcggcttct acgctccggc actctgagtt catcagcaaa 180
cgccctggcg tctgtcctca ccatgcctag cctttgggac cgcttctcgt cgtcgtccac 240
ctcctcttcg ccctcgtcct tgccccgaac tcccacccca gatcggccgc cgcgctcagc 300
ctgggggtcg gcgacccggg aggaggggtt tgaccgctcc acgagcctgg agagctcgga 360
ctgcgagtcc ctggacagca gcaacagtgg cttcgggccg gaggaagaca cggcttacct 420
ggatggggtg tcgttgcccg acttcgagct gctcagtgac cctgaggatg aacacttgtg 480
tgccaacctg atgcagctgc tgcaggagag cctggcccag gcgcggctgg gctctcgacg 540
ccctgcgcgc ctgctgatgc ctagccagtt ggtaagccag gtgggcaaag aactactgcg 600
cctggcctac agcgagccgt gcggcctgcg gggggcgctg ctggacgtct gcgtggagca 660
gggcaagagc tgccacagcg tgggccagct ggcactcgac cccagcctgg tgcccacctt 720
ccagctgacc ctcgtgctgc gcctggactc acgactctgg cccaagatcc aggggctgtt 780
tagctccgcc aactctccct tcctccctgg cttcagccag tccctgacgc tgagcactgg 840
cttccgagtc atcaagaaga agctgtacag ctcggaacag ctgctcattg aggagtgttg 900
aacttcaacc tgagggggcc gacagtgccc tccaagacag agacgactga acttttgggg 960
tggagactag aggcaggagc tgagggactg attcctgtgg ttggaaaact gaggcagcca 1020
cctaaggtgg aggtggggga atagtgtttc ccaggaagct cattgagttg tgtgcgggtg 1080
gctgtgcatt ggggacacat acccctcagt actgtagcat gaaacaaagg cttaggggcc 1140
aacaaggctt ccagctggat gtgtgtgtag catgtacctt attatttttg ttactgacag 1200
ttaacagtgg tgtgacatcc agagagcagc tgggctgctc ccgccccagc ccggcccagg 1260
gtgaaggaag aggcacgtgc tcctcagagc agccggaggg aggggggagg tcggaggtcg 1320
tggaggtggt ttgtgtatct tactggtctg aagggaccaa gtgtgtttgt tgtttgtttt 1380
gtatcttgtt tttctgatcg gagcatcact actgacctgt tgtaggcagc tatcttacag 1440
acgcatgaat gtaagagtag gaaggggtgg gtgtcaggga tcacttggga tctttgacac 1500
ttgaaaaatt acacctggca gctgcgttta agccttcccc catcgtgtac tgcagagttg 1560
agctggcagg ggaggggctg agagggtggg ggctggaacc cctccccggg aggagtgcca 1620
tctgggtctt ccatctagaa ctgtttacat gaagataaga tactcactgt tcatgaatac 1680
acttgatgtt caagtattaa gacctatgca atatttttta cttttctaat aaacatgttt 1740
gttaaaacag tt                                                     1752

<210> 2
<211> 232
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser
 1               5                  10                  15      
Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser
            20                  25                  30          
Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser
        35                  40                  45              
Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe
    50                  55                  60                  
Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp
65                  70                  75                  80  
Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu
                85                  90                  95      
Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg
            100                 105                 110         
Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly
        115                 120                 125             
Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly
    130                 135                 140                 
Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val
145                 150                 155                 160 
Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr
                165                 170                 175     
Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu
            180                 185                 190         
Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu
        195                 200                 205             
Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser
    210                 215                 220                 
Glu Gln Leu Leu Ile Glu Glu Cys
225                 230         


<210> 3
<211> 1081
<212> DNA
<213> Homo sapiens

<400> 3
gaggtcagag acttaagtct aaggcactga gcgtatcatg ttaaagatga gcgggtggca 60
gcgacagagc caaaatcaga gctggaacct gaggagagag tgttcaagaa ggaagtgtat 120
cttcatacat caccacacct gaaagcagca ccaaagcagc cataaacaat atgtaaataa 180
acagatgtgg ctgtattcca gtacaacttt acctacaaaa acaggcatca gaccagcttg 240
ccaacttgtg gcatagactg tttgctacat ggagcttgtt ccagccactc cccattatcc 300
tgcagatgtg cttttccaga ctgatccaac tgcagagatg gcagctgagt cattgccttt 360
ctccttcggg acactgtcca gctgggagct ggaagcctgg tatgaggacc tgcaagaggt 420
cctgtcttca gatgaaaatg ggggtaccta tgtttcacct cctggaaatg aagaggaaga 480
atcaaaaatc ttcaccactc ttgaccctgc ttctctggct tggctgactg aggaggagcc 540
agaaccagca gaggtcacaa gcacctccca gagccctcac tctccagatt ccagtcagag 600
ctccctggct caggaggaag aggaggaaga ccaagggaga accaggaaac ggaaacagag 660
tggtcattcc ccagcccggg ctggaaagca gcgcatgaag gagaaagaac aggagaatga 720
aaggaaagtg gcacagctag ctgaagagaa tgaacggctc aagcaggaaa tcgagcgcct 780
gaccagggaa gtagaggcga ctcgccgagc tctgattgac cgaatggtga atctgcacca 840
agcatgaaca attgggagca tcagtccccc acttgggcca cactacccac ctttcccaga 900
agtggctact gactaccctc tcactagtgc caatgatgtg accctcaatc ccacatacgc 960
agggggaagg cttggagtag acaaaaggaa aggtctcagc ttgtatatag agattgtaca 1020
tttatttatt actgtcccta tctattaaag tgactttcta tgagccaaaa aaaaaaaaaa 1080
a                                                                 1081

<210> 4
<211> 192
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Leu Val Pro Ala Thr Pro His Tyr Pro Ala Asp Val Leu Phe
 1               5                  10                  15      
Gln Thr Asp Pro Thr Ala Glu Met Ala Ala Glu Ser Leu Pro Phe Ser
            20                  25                  30          
Phe Gly Thr Leu Ser Ser Trp Glu Leu Glu Ala Trp Tyr Glu Asp Leu
        35                  40                  45              
Gln Glu Val Leu Ser Ser Asp Glu Asn Gly Gly Thr Tyr Val Ser Pro
    50                  55                  60                  
Pro Gly Asn Glu Glu Glu Glu Ser Lys Ile Phe Thr Thr Leu Asp Pro
65                  70                  75                  80  
Ala Ser Leu Ala Trp Leu Thr Glu Glu Glu Pro Glu Pro Ala Glu Val
                85                  90                  95      
Thr Ser Thr Ser Gln Ser Pro His Ser Pro Asp Ser Ser Gln Ser Ser
            100                 105                 110         
Leu Ala Gln Glu Glu Glu Glu Glu Asp Gln Gly Arg Thr Arg Lys Arg
        115                 120                 125             
Lys Gln Ser Gly His Ser Pro Ala Arg Ala Gly Lys Gln Arg Met Lys
    130                 135                 140                 
Glu Lys Glu Gln Glu Asn Glu Arg Lys Val Ala Gln Leu Ala Glu Glu
145                 150                 155                 160 
Asn Glu Arg Leu Lys Gln Glu Ile Glu Arg Leu Thr Arg Glu Val Glu
                165                 170                 175     
Ala Thr Arg Arg Ala Leu Ile Asp Arg Met Val Asn Leu His Gln Ala
            180                 185                 190         


<210> 5
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 5
ggcggaggtg gggttagctt cagttgacca accatgcctt gaggataaat tggatgggat 60
cagatgggaa gatgtgacaa gaagagaaat cctcctctat ataggatgct ctgctgtttc 120
ctaaggattt tcagcacctt gccccaaaat caaaatgatg cttcaacacc caggccaggt 180
ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc ctgtcccctc ctgggtcact 240
ggtgtttgag gattttgcta acctgacgcc ctttgtcaag gaagagctga ggtttgccat 300
ccagaacaag cacctctgcc accggatgtc ctctgcgctg gaatcagtca ctgtcagcga 360
cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc cctgaagaag atgaaaggaa 420
aaagaggcga cgagaaagaa ataagattgc agctgcaaag tgccgaaaca agaagaagga 480
gaagacggag tgcctgcaga aagagtcgga gaagctggaa agtgtgaatg ctgaactgaa 540
ggctcagatt gaggagctca agaacgagaa gcagcatttg atatacatgc tcaaccttca 600
tcggcccacg tgtattgtcc gggctcagaa tgggaggact ccagaagatg agagaaacct 660
ctttatccaa cagataaaag aaggaacatt gcagagctaa gcagtcgtgg tatgggggcg 720
actggggagt cctcattgaa tcctcatttt atacccaaaa ccctgaagcc attggagagc 780
tgtcttcctg tgtacctcta gaatcccagc agcagagaac catcaaggcg ggagggcctg 840
cagtgattca gcaggccctt cccattctgc cccagagtgg gtcttggacc agggcaagtg 900
catctttgcc tcaactccag gatttaggcc ttaacacact ggccattctt atgttccaga 960
tggcccccag ctggtgtcct gcccgccttt catctggatt ctacaaaaaa ccaggatgcc 1020
caccgttagg attcaggcag cagtgtctgt acctcgggtg ggagggatgg ggccatctcc 1080
ttcaccgtgg ctaccattgt cactcgtagg ggatgtggag tgagaacagc atttagtgaa 1140
gttgtgcaac ggccagggtt gtgctttcta gcaaatatgc tgttatgtcc agaaattgtg 1200
tgtgcaagaa aactaggcaa tgtactcttc cgatgtttgt gtcacacaac actgatgtga 1260
cttttatatg ctttttctca gatctggttt ctaagagttt tggggggcgg ggctgtcacc 1320
acgtgcagta tctcaagata ttcaggtggc cagaagagct tgtcagcaag aggaggacag 1380
aattctccca gcgttaacac aaaatccatg ggcagtatga tggcaggtcc tctgttgcaa 1440
actcagttcc aaagtcacag gaagaaagca gaaagttcaa cttccaaagg gttaggactc 1500
tccactcaat gtcttaggtc aggagttgtg tctaggctgg aagagccaaa gaatattcca 1560
ttttcctttc cttgtggttg aaaaccacag tcagtggaga gatgtttgga aaccacagtc 1620
agtggagcct gggtggtacc caggctttag cattattgga tgtcaatagc attgtttttg 1680
tcatgtagct gttttaagaa atctggccca gggtgtttgc agctgtgaga agtcactcac 1740
actggccaca aggacgctgg ctactgtcta ttaaaattct gatgtttctg tgaaattctc 1800
agagtgttta attgtactca atggtatcat tacaattttc tgtaagagaa aatattactt 1860
atttatccta gtattcctaa cctgtcagaa taataaatat tggaaccaag acatggtaaa 1920
caaaaaaaaa aaaaa                                                  1935

<210> 6
<211> 181
<212> PRT
<213> Homo sapiens

<400> 6
Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala
 1               5                  10                  15      
Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu
            20                  25                  30          
Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala
        35                  40                  45              
Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser
    50                  55                  60                  
Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu
65                  70                  75                  80  
Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn
                85                  90                  95      
Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu
            100                 105                 110         
Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu
        115                 120                 125             
Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr
    130                 135                 140                 
Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly
145                 150                 155                 160 
Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu
                165                 170                 175     
Gly Thr Leu Gln Ser
            180     


<210> 7
<211> 1523
<212> DNA
<213> Homo sapiens

<400> 7
ccgagcggtg ccaggccagg tgtgtgcgtc cgtcggtctt tccgtgccca cgccggagac 60
cagccccgga ggccgcctgg gcctatccct gtgccaggca ccatgaagca ggagtctgca 120
gccccgaaca ccccgcccac ctcgcagtcc cctacgccgt ccgctcagtt cccccgaaac 180
gacggcgacc ctcaagcgct gtggattttc gggtacggct ccctggtgtg gaggcccgac 240
ttcgcctaca gcgacagccg tgtgggcttc gtgcgcggct acagccgccg tttctggcag 300
ggagacacct tccatcgggg cagcgacaag atgcctggcc gtgtggtgac gctccttgaa 360
gatcatgagg gctgcacttg gggcgtggca taccaagtgc aaggggagca ggtaagcaag 420
gccctgaagt acctgaatgt gcgagaggca gtgcttggtg gctacgatac caaggaggtc 480
accttctatc cccaagatgc tcctgaccaa ccactgaagg cattggccta tgtggccacc 540
ccacagaacc ctggttacct gggccctgcg cctgaagagg ccattgccac gcagatcctg 600
gcctgccggg gcttctccgg ccacaacctt gaatacttgc tgcgtctggc agacttcatg 660
cagctctgtg ggcctcaggc gcaggacgag cacctggcag ccatcgtgga cgctgtgggc 720
accatgttgc cctgcttctg ccccaccgag caggctctgg cgctggtgtg aggggctgag 780
cccctgcggg gagtgctcat gtggacatca gggccagaca cccactccag tgcacaagac 840
agacttgcga ccgcttgagc ccactgagca gatatggtgg gtggctggag gcttctcttt 900
ctcagtccct gcctgtctgc cagcctgcag ctctcctgct tgacactgac ttactacttg 960
aaactttatt tattgcacca tgttggtgtg gtgggcaggt ggagggcctg ccctggacac 1020
aggggccctg ctgagcagtg gccccatcct ggaacttgac cagattcccc ccagtgctgc 1080
tgctaacccc acaccaccca ggcctccacc tccccaggga gtctccaaga gcctcgatcc 1140
tctgctcact cagcccagcc atccatagcc ctgggaattc cacctgccaa ggatcccagc 1200
aggctggatg agggatagta gggcatgagg agaaggagcc ctgtaaggac tgaggccccg 1260
gccagccctt ctcctccacc agttccccag agcagagctg gagctgatgc ctggacacag 1320
ctgctgagcc tggcctgggc ctcttaccca cttggttgtt ttcttgtccc tctgtctgtc 1380
tgtctatcta cttgtctgtc tgggccactc ctgcctgtgt gttggtctat tcctgggaag 1440
ctcatcacta caggccctgg caaccttccc agtctgtccc atactgttac ccataaaact 1500
atctctttaa aaaaaaaaaa aaa                                         1523

<210> 8
<211> 222
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Gln Glu Ser Ala Ala Pro Asn Thr Pro Pro Thr Ser Gln Ser
 1               5                  10                  15      
Pro Thr Pro Ser Ala Gln Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala
            20                  25                  30          
Leu Trp Ile Phe Gly Tyr Gly Ser Leu Val Trp Arg Pro Asp Phe Ala
        35                  40                  45              
Tyr Ser Asp Ser Arg Val Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe
    50                  55                  60                  
Trp Gln Gly Asp Thr Phe His Arg Gly Ser Asp Lys Met Pro Gly Arg
65                  70                  75                  80  
Val Val Thr Leu Leu Glu Asp His Glu Gly Cys Thr Trp Gly Val Ala
                85                  90                  95      
Tyr Gln Val Gln Gly Glu Gln Val Ser Lys Ala Leu Lys Tyr Leu Asn
            100                 105                 110         
Val Arg Glu Ala Val Leu Gly Gly Tyr Asp Thr Lys Glu Val Thr Phe
        115                 120                 125             
Tyr Pro Gln Asp Ala Pro Asp Gln Pro Leu Lys Ala Leu Ala Tyr Val
    130                 135                 140                 
Ala Thr Pro Gln Asn Pro Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala
145                 150                 155                 160 
Ile Ala Thr Gln Ile Leu Ala Cys Arg Gly Phe Ser Gly His Asn Leu
                165                 170                 175     
Glu Tyr Leu Leu Arg Leu Ala Asp Phe Met Gln Leu Cys Gly Pro Gln
            180                 185                 190         
Ala Gln Asp Glu His Leu Ala Ala Ile Val Asp Ala Val Gly Thr Met
        195                 200                 205             
Leu Pro Cys Phe Cys Pro Thr Glu Gln Ala Leu Ala Leu Val
    210                 215                 220         


<210> 9
<211> 2022
<212> DNA
<213> Homo sapiens

<400> 9
tttctacttt gcccgcccac agatgtagtt ttctctgcgc gtgtgcgttt tccctcctcc 60
ccgccctcag ggtccacggc caccatggcg tattaggggc agcagtgcct gcggcagcat 120
tggcctttgc agcggcggca gcagcaccag gctctgcagc ggcaaccccc agcggcttaa 180
gccatggcgt gagtaccggg gcgggtcgtc cagctgtgct cctggggccg gcgcgggttt 240
tggattggtg gggtgcggcc tggggccagg gcggtgccgc caagggggaa gcgatttaac 300
gagcgcccgg gacgcgtggt ctttgcttgg gtgtccccga gacgctcgcg tgcctgggat 360
cgggaaagcg tagtcgggtg cccggactgc ttccccagga gccctacagc cctcggaccc 420
cgagccccgc aagggtccca ggggtcttgg ctgttgcccc acgaaacgtg gcaggaacca 480
agatggcggc ggcagggcgg cggcgcgggc gtgagtcaag ggcgggcggt gggcggggcg 540
cggccgccct ggccgtattt ggacgtgggg acggagcgct ttcctcttgg cggccggtgg 600
aagaatcccc tggtctccgt gagcgtccat tttgtggaac ctgagttgca agcagggagg 660
ggcaaataca actgccctgt tcccgattct ctagatggcc gatctagaga agtcccgcct 720
cataagtgga aggatgaaat tctcagaaca gctaacctct aatgggagtt ggcttctgat 780
tctcattcag gcttctcacg gcattcagca gcagcgttgc tgtaaccgac aaagacacct 840
tcgaattaag cacattcctc gattccagca aagcaccgca acatgaccga aatgagcttc 900
ctgagcagcg aggtgttggt gggggacttg atgtccccct tcgaccagtc gggtttgggg 960
gctgaagaaa gcctaggtct cttagatgat tacctggagg tggccaagca cttcaaacct 1020
catgggttct ccagcgacaa ggctaaggcg ggctcctccg aatggctggc tgtggatggg 1080
ttggtcagtc cctccaacaa cagcaaggag gatgccttct ccgggacaga ttggatgttg 1140
gagaaaatgg atttgaagga gttcgacttg gatgccctgt tgggtataga tgacctggaa 1200
accatgccag atgaccttct gaccacgttg gatgacactt gtgatctctt tgccccccta 1260
gtccaggaga ctaataagca gcccccccag acggtgaacc caattggcca tctcccagaa 1320
agtttaacaa aacccgacca ggttgccccc ttcaccttct tacaacctct tcccctttcc 1380
ccaggggtcc tgtcctccac tccagatcat tcctttagtt tagagctggg cagtgaagtg 1440
gatatcactg aaggagatag gaagccagac tacactgctt acgttgccat gatccctcag 1500
tgcataaagg aggaagacac cccttcagat aatgatagtg gcatctgtat gagcccagag 1560
tcctatctgg ggtctcctca gcacagcccc tctaccaggg gctctccaaa taggagcctc 1620
ccatctccag gtgttctctg tgggtctgcc cgtcccaaac cttacgatcc tcctggagag 1680
aagatggtag cagcaaaagt aaagggtgag aaactggata agaagctgaa aaaaatggag 1740
caaaacaaga cagcagccac taggtaccgc cagaagaaga gggcggagca ggaggctctt 1800
actggtgagt gcaaagagct ggaaaagaag aacgaggctc taaaagagag ggcggattcc 1860
ctggccaagg agatccagta cctgaaagat ttgatagaag aggtccgcaa ggcaaggggg 1920
aagaaaaggg tcccctagtt gaggatagtc aggagcgtca atgtgcttgt acatagagtg 1980
ctgtagctgt gtgttccaat aaattatttt gtagggaaag ta                    2022

<210> 10
<211> 351
<212> PRT
<213> Homo sapiens

<400> 10
Met Thr Glu Met Ser Phe Leu Ser Ser Glu Val Leu Val Gly Asp Leu
 1               5                  10                  15      
Met Ser Pro Phe Asp Gln Ser Gly Leu Gly Ala Glu Glu Ser Leu Gly
            20                  25                  30          
Leu Leu Asp Asp Tyr Leu Glu Val Ala Lys His Phe Lys Pro His Gly
        35                  40                  45              
Phe Ser Ser Asp Lys Ala Lys Ala Gly Ser Ser Glu Trp Leu Ala Val
    50                  55                  60                  
Asp Gly Leu Val Ser Pro Ser Asn Asn Ser Lys Glu Asp Ala Phe Ser
65                  70                  75                  80  
Gly Thr Asp Trp Met Leu Glu Lys Met Asp Leu Lys Glu Phe Asp Leu
                85                  90                  95      
Asp Ala Leu Leu Gly Ile Asp Asp Leu Glu Thr Met Pro Asp Asp Leu
            100                 105                 110         
Leu Thr Thr Leu Asp Asp Thr Cys Asp Leu Phe Ala Pro Leu Val Gln
        115                 120                 125             
Glu Thr Asn Lys Gln Pro Pro Gln Thr Val Asn Pro Ile Gly His Leu
    130                 135                 140                 
Pro Glu Ser Leu Thr Lys Pro Asp Gln Val Ala Pro Phe Thr Phe Leu
145                 150                 155                 160 
Gln Pro Leu Pro Leu Ser Pro Gly Val Leu Ser Ser Thr Pro Asp His
                165                 170                 175     
Ser Phe Ser Leu Glu Leu Gly Ser Glu Val Asp Ile Thr Glu Gly Asp
            180                 185                 190         
Arg Lys Pro Asp Tyr Thr Ala Tyr Val Ala Met Ile Pro Gln Cys Ile
        195                 200                 205             
Lys Glu Glu Asp Thr Pro Ser Asp Asn Asp Ser Gly Ile Cys Met Ser
    210                 215                 220                 
Pro Glu Ser Tyr Leu Gly Ser Pro Gln His Ser Pro Ser Thr Arg Gly
225                 230                 235                 240 
Ser Pro Asn Arg Ser Leu Pro Ser Pro Gly Val Leu Cys Gly Ser Ala
                245                 250                 255     
Arg Pro Lys Pro Tyr Asp Pro Pro Gly Glu Lys Met Val Ala Ala Lys
            260                 265                 270         
Val Lys Gly Glu Lys Leu Asp Lys Lys Leu Lys Lys Met Glu Gln Asn
        275                 280                 285             
Lys Thr Ala Ala Thr Arg Tyr Arg Gln Lys Lys Arg Ala Glu Gln Glu
    290                 295                 300                 
Ala Leu Thr Gly Glu Cys Lys Glu Leu Glu Lys Lys Asn Glu Ala Leu
305                 310                 315                 320 
Lys Glu Arg Ala Asp Ser Leu Ala Lys Glu Ile Gln Tyr Leu Lys Asp
                325                 330                 335     
Leu Ile Glu Glu Val Arg Lys Ala Arg Gly Lys Lys Arg Val Pro
            340                 345                 350     


<210> 11
<211> 8733
<212> DNA
<213> Homo sapiens

<400> 11
gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg 60
gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa 120
gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag 180
cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc 240
cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc 300
tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc 360
caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa 420
tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc 480
agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt 540
taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg 600
caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc 660
taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga 720
ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac 780
aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga 840
agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg 900
gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga 960
gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg 1020
caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca 1080
ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca 1140
aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg 1200
gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg 1260
caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc 1320
tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt 1380
cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact 1440
ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg 1500
agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc 1560
cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga 1620
tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt 1680
gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact 1740
gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg 1800
cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg 1860
cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac 1920
ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat 1980
ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca 2040
tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct 2100
cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga 2160
cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct 2220
gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag 2280
catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga 2340
gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct 2400
ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat 2460
tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc 2520
aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact 2580
ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc 2640
tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa 2700
gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac 2760
acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa 2820
agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc 2880
caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa 2940
cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg 3000
agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa 3060
gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt 3120
cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt 3180
gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga 3240
attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt 3300
ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg 3360
tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat 3420
ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa 3480
gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga 3540
ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt 3600
tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact 3660
tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt 3720
gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata 3780
cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg 3840
ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt 3900
cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg 3960
gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct 4020
gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc 4080
tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag 4140
catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt 4200
ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat 4260
tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa 4320
agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa 4380
taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt 4440
tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct 4500
tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg 4560
catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa 4620
gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc 4680
atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac 4740
ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc 4800
acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg 4860
agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga 4920
ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg 4980
ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg 5040
gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg 5100
cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga 5160
tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta 5220
catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt 5280
tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa 5340
gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa 5400
tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac 5460
agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc 5520
tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc 5580
cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac 5640
cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc 5700
caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta 5760
cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct 5820
ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa 5880
tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc 5940
tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct 6000
tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc 6060
taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga 6120
gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc 6180
catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg 6240
ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg 6300
gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga 6360
ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc 6420
ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc 6480
cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt 6540
gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt 6600
gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca 6660
tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca 6720
gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct 6780
cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt 6840
tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct 6900
tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct 6960
gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc 7020
caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta 7080
tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca 7140
cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga 7200
ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac 7260
aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg 7320
ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc 7380
ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa 7440
gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg 7500
tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca 7560
ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat 7620
tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga 7680
tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca 7740
gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt 7800
tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag 7860
tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg 7920
gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat 7980
ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg 8040
aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc 8100
ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac 8160
tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa 8220
gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga 8280
cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca 8340
gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt 8400
ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg 8460
ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac 8520
tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg 8580
aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt 8640
ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat 8700
gacatcagaa ttttaaacat atgtaaaaaa aaa                              8733



<210> 12
<211> 2549
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser
 1               5                  10                  15      
Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg
            20                  25                  30          
Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val
        35                  40                  45              
Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr
    50                  55                  60                  
Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala
65                  70                  75                  80  
Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val
                85                  90                  95      
Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg
            100                 105                 110         
Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys
        115                 120                 125             
Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr
    130                 135                 140                 
Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg
145                 150                 155                 160 
Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala
                165                 170                 175     
Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp
            180                 185                 190         
Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly
        195                 200                 205             
Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu
    210                 215                 220                 
Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu
225                 230                 235                 240 
Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn
                245                 250                 255     
Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val
            260                 265                 270         
Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu
        275                 280                 285             
Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met
    290                 295                 300                 
Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln
305                 310                 315                 320 
Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr
                325                 330                 335     
Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala
            340                 345                 350         
Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu
        355                 360                 365             
Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys
    370                 375                 380                 
Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala
385                 390                 395                 400 
Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr
                405                 410                 415     
Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala
            420                 425                 430         
Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe
        435                 440                 445             
Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro
    450                 455                 460                 
Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala
465                 470                 475                 480 
Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly
                485                 490                 495     
Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly
            500                 505                 510         
Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile
        515                 520                 525             
Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser
    530                 535                 540                 
Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly
545                 550                 555                 560 
Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala
                565                 570                 575     
Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe
            580                 585                 590         
Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp
        595                 600                 605             
His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg
    610                 615                 620                 
Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His
625                 630                 635                 640 
Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu
                645                 650                 655     
Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg
            660                 665                 670         
Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala
        675                 680                 685             
Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val
    690                 695                 700                 
Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser
705                 710                 715                 720 
Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln
                725                 730                 735     
Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln
            740                 745                 750         
Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile
        755                 760                 765             
Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys
    770                 775                 780                 
Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala
785                 790                 795                 800 
Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp
                805                 810                 815     
Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser
            820                 825                 830         
Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val
        835                 840                 845             
Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu
    850                 855                 860                 
Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr
865                 870                 875                 880 
Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro
                885                 890                 895     
Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala
            900                 905                 910         
Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp
        915                 920                 925             
Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp
    930                 935                 940                 
Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg
945                 950                 955                 960 
Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr
                965                 970                 975     
Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln
            980                 985                 990         
Val Met Pro Thr Phe Leu Asn Val Ile Arg Val Cys Asp Gly Ala Ile
        995                 1000                1005            
Arg Glu Phe Leu Phe Gln Gln Leu Gly Met Leu Val Ser Phe Val Lys
    1010                1015                1020                
Ser His Ile Arg Pro Tyr Met Asp Glu Ile Val Thr Leu Met Arg Glu
1025                1030                1035               1040 
Phe Trp Val Met Asn Thr Ser Ile Gln Ser Thr Ile Ile Leu Leu Ile
                1045                1050                1055    
Glu Gln Ile Val Val Ala Leu Gly Gly Glu Phe Lys Leu Tyr Leu Pro
            1060                1065                1070        
Gln Leu Ile Pro His Met Leu Arg Val Phe Met His Asp Asn Ser Pro
        1075                1080                1085            
Gly Arg Ile Val Ser Ile Lys Leu Leu Ala Ala Ile Gln Leu Phe Gly
    1090                1095                1100                
Ala Asn Leu Asp Asp Tyr Leu His Leu Leu Leu Pro Pro Ile Val Lys
1105                1110                1115               1120 
Leu Phe Asp Ala Pro Glu Ala Pro Leu Pro Ser Arg Lys Ala Ala Leu
                1125                1130                1135    
Glu Thr Val Asp Arg Leu Thr Glu Ser Leu Asp Phe Thr Asp Tyr Ala
            1140                1145                1150        
Ser Arg Ile Ile His Pro Ile Val Arg Thr Leu Asp Gln Ser Pro Glu
        1155                1160                1165            
Leu Arg Ser Thr Ala Met Asp Thr Leu Ser Ser Leu Val Phe Gln Leu
    1170                1175                1180                
Gly Lys Lys Tyr Gln Ile Phe Ile Pro Met Val Asn Lys Val Leu Val
1185                1190                1195               1200 
Arg His Arg Ile Asn His Gln Arg Tyr Asp Val Leu Ile Cys Arg Ile
                1205                1210                1215    
Val Lys Gly Tyr Thr Leu Ala Asp Glu Glu Glu Asp Pro Leu Ile Tyr
            1220                1225                1230        
Gln His Arg Met Leu Arg Ser Gly Gln Gly Asp Ala Leu Ala Ser Gly
        1235                1240                1245            
Pro Val Glu Thr Gly Pro Met Lys Lys Leu His Val Ser Thr Ile Asn
    1250                1255                1260                
Leu Gln Lys Ala Trp Gly Ala Ala Arg Arg Val Ser Lys Asp Asp Trp
1265                1270                1275               1280 
Leu Glu Trp Leu Arg Arg Leu Ser Leu Glu Leu Leu Lys Asp Ser Ser
                1285                1290                1295    
Ser Pro Ser Leu Arg Ser Cys Trp Ala Leu Ala Gln Ala Tyr Asn Pro
            1300                1305                1310        
Met Ala Arg Asp Leu Phe Asn Ala Ala Phe Val Ser Cys Trp Ser Glu
        1315                1320                1325            
Leu Asn Glu Asp Gln Gln Asp Glu Leu Ile Arg Ser Ile Glu Leu Ala
    1330                1335                1340                
Leu Thr Ser Gln Asp Ile Ala Glu Val Thr Gln Thr Leu Leu Asn Leu
1345                1350                1355               1360 
Ala Glu Phe Met Glu His Ser Asp Lys Gly Pro Leu Pro Leu Arg Asp
                1365                1370                1375    
Asp Asn Gly Ile Val Leu Leu Gly Glu Arg Ala Ala Lys Cys Arg Ala
            1380                1385                1390        
Tyr Ala Lys Ala Leu His Tyr Lys Glu Leu Glu Phe Gln Lys Gly Pro
        1395                1400                1405            
Thr Pro Ala Ile Leu Glu Ser Leu Ile Ser Ile Asn Asn Lys Leu Gln
    1410                1415                1420                
Gln Pro Glu Ala Ala Ala Gly Val Leu Glu Tyr Ala Met Lys His Phe
1425                1430                1435               1440 
Gly Glu Leu Glu Ile Gln Ala Thr Trp Tyr Glu Lys Leu His Glu Trp
                1445                1450                1455    
Glu Asp Ala Leu Val Ala Tyr Asp Lys Lys Met Asp Thr Asn Lys Asp
            1460                1465                1470        
Asp Pro Glu Leu Met Leu Gly Arg Met Arg Cys Leu Glu Ala Leu Gly
        1475                1480                1485            
Glu Trp Gly Gln Leu His Gln Gln Cys Cys Glu Lys Trp Thr Leu Val
    1490                1495                1500                
Asn Asp Glu Thr Gln Ala Lys Met Ala Arg Met Ala Ala Ala Ala Ala
1505                1510                1515               1520 
Trp Gly Leu Gly Gln Trp Asp Ser Met Glu Glu Tyr Thr Cys Met Ile
                1525                1530                1535    
Pro Arg Asp Thr His Asp Gly Ala Phe Tyr Arg Ala Val Leu Ala Leu
            1540                1545                1550        
His Gln Asp Leu Phe Ser Leu Ala Gln Gln Cys Ile Asp Lys Ala Arg
        1555                1560                1565            
Asp Leu Leu Asp Ala Glu Leu Thr Ala Met Ala Gly Glu Ser Tyr Ser
    1570                1575                1580                
Arg Ala Tyr Gly Ala Met Val Ser Cys His Met Leu Ser Glu Leu Glu
1585                1590                1595               1600 
Glu Val Ile Gln Tyr Lys Leu Val Pro Glu Arg Arg Glu Ile Ile Arg
                1605                1610                1615    
Gln Ile Trp Trp Glu Arg Leu Gln Gly Cys Gln Arg Ile Val Glu Asp
            1620                1625                1630        
Trp Gln Lys Ile Leu Met Val Arg Ser Leu Val Val Ser Pro His Glu
        1635                1640                1645            
Asp Met Arg Thr Trp Leu Lys Tyr Ala Ser Leu Cys Gly Lys Ser Gly
    1650                1655                1660                
Arg Leu Ala Leu Ala His Lys Thr Leu Val Leu Leu Leu Gly Val Asp
1665                1670                1675               1680 
Pro Ser Arg Gln Leu Asp His Pro Leu Pro Thr Val His Pro Gln Val
                1685                1690                1695    
Thr Tyr Ala Tyr Met Lys Asn Met Trp Lys Ser Ala Arg Lys Ile Asp
            1700                1705                1710        
Ala Phe Gln His Met Gln His Phe Val Gln Thr Met Gln Gln Gln Ala
        1715                1720                1725            
Gln His Ala Ile Ala Thr Glu Asp Gln Gln His Lys Gln Glu Leu His
    1730                1735                1740                
Lys Leu Met Ala Arg Cys Phe Leu Lys Leu Gly Glu Trp Gln Leu Asn
1745                1750                1755               1760 
Leu Gln Gly Ile Asn Glu Ser Thr Ile Pro Lys Val Leu Gln Tyr Tyr
                1765                1770                1775    
Ser Ala Ala Thr Glu His Asp Arg Ser Trp Tyr Lys Ala Trp His Ala
            1780                1785                1790        
Trp Ala Val Met Asn Phe Glu Ala Val Leu His Tyr Lys His Gln Asn
        1795                1800                1805            
Gln Ala Arg Asp Glu Lys Lys Lys Leu Arg His Ala Ser Gly Ala Asn
    1810                1815                1820                
Ile Thr Asn Ala Thr Thr Ala Ala Thr Thr Ala Ala Thr Ala Thr Thr
1825                1830                1835               1840 
Thr Ala Ser Thr Glu Gly Ser Asn Ser Glu Ser Glu Ala Glu Ser Thr
                1845                1850                1855    
Glu Asn Ser Pro Thr Pro Ser Pro Leu Gln Lys Lys Val Thr Glu Asp
            1860                1865                1870        
Leu Ser Lys Thr Leu Leu Met Tyr Thr Val Pro Ala Val Gln Gly Phe
        1875                1880                1885            
Phe Arg Ser Ile Ser Leu Ser Arg Gly Asn Asn Leu Gln Asp Thr Leu
    1890                1895                1900                
Arg Val Leu Thr Leu Trp Phe Asp Tyr Gly His Trp Pro Asp Val Asn
1905                1910                1915               1920 
Glu Ala Leu Val Glu Gly Val Lys Ala Ile Gln Ile Asp Thr Trp Leu
                1925                1930                1935    
Gln Val Ile Pro Gln Leu Ile Ala Arg Ile Asp Thr Pro Arg Pro Leu
            1940                1945                1950        
Val Gly Arg Leu Ile His Gln Leu Leu Thr Asp Ile Gly Arg Tyr His
        1955                1960                1965            
Pro Gln Ala Leu Ile Tyr Pro Leu Thr Val Ala Ser Lys Ser Thr Thr
    1970                1975                1980                
Thr Ala Arg His Asn Ala Ala Asn Lys Ile Leu Lys Asn Met Cys Glu
1985                1990                1995               2000 
His Ser Asn Thr Leu Val Gln Gln Ala Met Met Val Ser Glu Glu Leu
                2005                2010                2015    
Ile Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu
            2020                2025                2030        
Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe
        2035                2040                2045            
Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr
    2050                2055                2060                
Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu
2065                2070                2075               2080 
Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp
                2085                2090                2095    
Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser
            2100                2105                2110        
Lys Gln Leu Pro Gln Leu Thr Ser Leu Glu Leu Gln Tyr Val Ser Pro
        2115                2120                2125            
Lys Leu Leu Met Cys Arg Asp Leu Glu Leu Ala Val Pro Gly Thr Tyr
    2130                2135                2140                
Asp Pro Asn Gln Pro Ile Ile Arg Ile Gln Ser Ile Ala Pro Ser Leu
2145                2150                2155               2160 
Gln Val Ile Thr Ser Lys Gln Arg Pro Arg Lys Leu Thr Leu Met Gly
                2165                2170                2175    
Ser Asn Gly His Glu Phe Val Phe Leu Leu Lys Gly His Glu Asp Leu
            2180                2185                2190        
Arg Gln Asp Glu Arg Val Met Gln Leu Phe Gly Leu Val Asn Thr Leu
        2195                2200                2205            
Leu Ala Asn Asp Pro Thr Ser Leu Arg Lys Asn Leu Ser Ile Gln Arg
    2210                2215                2220                
Tyr Ala Val Ile Pro Leu Ser Thr Asn Ser Gly Leu Ile Gly Trp Val
2225                2230                2235               2240 
Pro His Cys Asp Thr Leu His Ala Leu Ile Arg Asp Tyr Arg Glu Lys
                2245                2250                2255    
Lys Lys Ile Leu Leu Asn Ile Glu His Arg Ile Met Leu Arg Met Ala
            2260                2265                2270        
Pro Asp Tyr Asp His Leu Thr Leu Met Gln Lys Val Glu Val Phe Glu
        2275                2280                2285            
His Ala Val Asn Asn Thr Ala Gly Asp Asp Leu Ala Lys Leu Leu Trp
    2290                2295                2300                
Leu Lys Ser Pro Ser Ser Glu Val Trp Phe Asp Arg Arg Thr Asn Tyr
2305                2310                2315               2320 
Thr Arg Ser Leu Ala Val Met Ser Met Val Gly Tyr Ile Leu Gly Leu
                2325                2330                2335    
Gly Asp Arg His Pro Ser Asn Leu Met Leu Asp Arg Leu Ser Gly Lys
            2340                2345                2350        
Ile Leu His Ile Asp Phe Gly Asp Cys Phe Glu Val Ala Met Thr Arg
        2355                2360                2365            
Glu Lys Phe Pro Glu Lys Ile Pro Phe Arg Leu Thr Arg Met Leu Thr
    2370                2375                2380                
Asn Ala Met Glu Val Thr Gly Leu Asp Gly Asn Tyr Arg Ile Thr Cys
2385                2390                2395               2400 
His Thr Val Met Glu Val Leu Arg Glu His Lys Asp Ser Val Met Ala
                2405                2410                2415    
Val Leu Glu Ala Phe Val Tyr Asp Pro Leu Leu Asn Trp Arg Leu Met
            2420                2425                2430        
Asp Thr Asn Thr Lys Gly Asn Lys Arg Ser Arg Thr Arg Thr Asp Ser
        2435                2440                2445            
Tyr Ser Ala Gly Gln Ser Val Glu Ile Leu Asp Gly Val Glu Leu Gly
    2450                2455                2460                
Glu Pro Ala His Lys Lys Thr Gly Thr Thr Val Pro Glu Ser Ile His
2465                2470                2475               2480 
Ser Phe Ile Gly Asp Gly Leu Val Lys Pro Glu Ala Leu Asn Lys Lys
                2485                2490                2495    
Ala Ile Gln Ile Ile Asn Arg Val Arg Asp Lys Leu Thr Gly Arg Asp
            2500                2505                2510        
Phe Ser His Asp Asp Thr Leu Asp Val Pro Thr Gln Val Glu Leu Leu
        2515                2520                2525            
Ile Lys Gln Ala Thr Ser His Glu Asn Leu Cys Gln Cys Tyr Ile Gly
    2530                2535                2540                
Trp Cys Pro Phe Trp
2545                


<210> 13
<211> 3648
<212> DNA
<213> Homo sapiens

<400> 13
gcgcaaccct ccggaagctg ccgccccttt ccccttttat gggaatactt tttttaaaaa 60
aaaagagttc gctggcgcca ccccgtagga ctggccgccc taaaaccgtg ataaaggagc 120
tgctcgccac ttctcacttc cgcttccttc cagtaaggag tcggggtctt ccccagtttt 180
ctcagccagg cggcggcggc gactggcaat gtttggcctc aaaagaaacg cggtaatcgg 240
actcaacctc tactgtgggg gggccggctt gggggccggc agcggcggcg ccacccgccc 300
gggagggcga cttttggcca ccggcgccaa ggacacaaag ccaatgggca ggtctggggc 360
caccagcagg aaggcgctgg agaccttacg acgggttggg gatggcgtgc agcgcaacca 420
cgagacggcc ttccaaggca tgcttcggaa actggacatc aaaaacgaag acgatgtgaa 480
atcgttgtct cgagtgatga tccatgtttt cagcgacggc gtaacaaact ggggcaggat 540
tgtgactctc atttcttttg gtgcctttgt ggctaaacac ttgaagacca taaaccaaga 600
aagctgcatc gaaccattag cagaaagtat cacagacgtt ctcgtaagga caaaacggga 660
ctggctagtt aaacaaagag gctgggatgg gtttgtggag ttcttccatg tagaggacct 720
agaaggtggc atcaggaatg tgctgctggc ttttgcaggt gttgctggag taggagctgg 780
tttggcatat ctaataagat agccttactg taagtgcaat agttgacttt taaccaacca 840
ccaccaccac caaaaccagt ttatgcagtt ggactccaag ctgtaacttc ctagagttgc 900
accctagcaa cctagccaga aaagcaagtg gcaagaggat tatggctaac aagaataaat 960
acatgggaag agtgctcccc attgattgaa gagtcactgt ctgaaagaag caaagttcag 1020
tttcagcaac aaacaaactt tgtttgggaa gctatggagg aggactttta gatttagtga 1080
agatggtagg gtggaaagac ttaatttcct tgttgagaac aggaaagtgg ccagtagcca 1140
ggcaagtcat agaattgatt acccgccgaa ttcattaatt tactgtagtg ttaagagaag 1200
cactaagaat gccagtgacc tgtgtaaaag ttacaagtaa tagaactatg actgtaagcc 1260
tcagtactgt acaagggaag cttttcctct ctctaattag ctttcccagt atacttctta 1320
gaaagtccaa gtgttcagga cttttatacc tgttatactt tggcttggtt tccatgattc 1380
ttactttatt agcctagttt atcaccaata atacttgacg gaaggctcag taattagtta 1440
tgaatatgga tatcctcaat tcttaagaca gcttgtaaat gtatttgtaa aaattgtata 1500
tatttttaca gaaagtctat ttctttgaaa cgaaggaagt atcgaattta cattagtttt 1560
tttcataccc ttttgaactt tgcaacttcc gtaattagga acctgtttct tacagctttt 1620
ctatgctaaa ctttgttctg ttcagttcta gagtgtatac agaacgaatt gatgtgtaac 1680
tgtatgcaga ctggttgtag tggaacaaat ctgataacta tgcaggttta aattttctta 1740
tctgattttg gtaagtattc cttagatagg tttttctttg aaaacctggg attgagaggt 1800
tgatgaatgg aaattctttc acttcattat atgcaagttt tcaataatta ggtctaagtg 1860
gagttttaag gttactgatg acttacaaat aatgggctct gattgggcaa tactcatttg 1920
agttccttcc atttgaccta atttaactgg tgaaatttaa agtgaattca tgggctcatc 1980
tttaaagctt ttactaaaag attttcagct gaatggaact cattagctgt gtgcatataa 2040
aaagatcaca tcaggtggat ggagagacat ttgatccctt gtttgcttaa taaattataa 2100
aatgatggct tggaaaagca ggctagtcta accatggtgc tattattagg cttgcttgtt 2160
acacacacag gtctaagcct agtatgtcaa taaagcaaat acttactgtt ttgtttctat 2220
taatgattcc caaaccttgt tgcaagtttt tgcattggca tctttggatt tcagtcttga 2280
tgtttgttct atcagactta accttttatt tcctgtcctt ccttgaaatt gctgattgtt 2340
ctgctccctc tacagatatt tatatcaatt cctacagctt tcccctgcca tccctgaact 2400
ctttctagcc cttttagatt ttggcactgt gaaacccctg ctggaaacct gagtgaccct 2460
ccctccccac caagagtcca cagacctttc atctttcacg aacttgatcc tgttagcagg 2520
tggtaatacc atgggtgctg tgacactaac agtcattgag aggtgggagg aagtcccttt 2580
tccttggact ggtatctttt caactattgt tttatcctgt ctttgggggc aatgtgtcaa 2640
aagtcccctc aggaattttc agaggaaaga acattttatg aggctttctc taaagtttcc 2700
tttgtatagg agtatgctca cttaaattta cagaaagagg tgagctgtgt taaacctcag 2760
agtttaaaag ctactgataa actgaagaaa gtgtctatat tggaactagg gtcatttgaa 2820
agcttcagtc tcggaacatg acctttagtc tgtggactcc atttaaaaat aggtatgaat 2880
aagatgacta agaatgtaat ggggaagaac tgccctgcct gcccatctca gagccataag 2940
gtcatctttg ctagagctat ttttacctat gtatttatcg ttcttgatca taagccgctt 3000
atttatatca tgtatctcta aggacctaaa agcactttat gtagttttta attaatctta 3060
agatctggtt acggtaacta aaaaagcctg tctgccaaat ccagtggaaa caagtgcata 3120
gatgtgaatt ggtttttagg ggccccactt cccaattcat taggtatgac tgtggaaata 3180
cagacaagga tcttagttga tattttgggc ttggggcagt gagggcttag gacaccccaa 3240
gtggtttggg aaaggaggag gggagtggtg ggtttatagg gggaggagga ggcaggtggt 3300
ctaagtgctg actggctacg tagttcgggc aaatcctcca aaagggaaag ggaggatttg 3360
cttagaagga tggcgctccc agtgactact ttttgacttc tgtttgtctt acgcttctct 3420
cagggaaaaa catgcagtcc tctagtgttt catgtacatt ctgtgggggg tgaacacctt 3480
ggttctggtt aaacagctgt acttttgata gctgtgccag gaagggttag gaccaactac 3540
aaattaatgt tggttgtcaa atgtagtgtg tttccctaac tttctgtttt tcctgagaaa 3600
aaaaaataaa tcttttattc aaatacaggg aaaaaaaaaa aaaaaaaa              3648

<210> 14
<211> 197
<212> PRT
<213> Homo sapiens

<400> 14
Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys
 1               5                  10                  15      
Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly
            20                  25                  30          
Gly Arg Leu Leu Ala Thr Gly Ala Lys Asp Thr Lys Pro Met Gly Arg
        35                  40                  45              
Ser Gly Ala Thr Ser Arg Lys Ala Leu Glu Thr Leu Arg Arg Val Gly
    50                  55                  60                  
Asp Gly Val Gln Arg Asn His Glu Thr Ala Phe Gln Gly Met Leu Arg
65                  70                  75                  80  
Lys Leu Asp Ile Lys Asn Glu Asp Asp Val Lys Ser Leu Ser Arg Val
                85                  90                  95      
Met Ile His Val Phe Ser Asp Gly Val Thr Asn Trp Gly Arg Ile Val
            100                 105                 110         
Thr Leu Ile Ser Phe Gly Ala Phe Val Ala Lys His Leu Lys Thr Ile
        115                 120                 125             
Asn Gln Glu Ser Cys Ile Glu Pro Leu Ala Glu Ser Ile Thr Asp Val
    130                 135                 140                 
Leu Val Arg Thr Lys Arg Asp Trp Leu Val Lys Gln Arg Gly Trp Asp
145                 150                 155                 160 
Gly Phe Val Glu Phe Phe His Val Glu Asp Leu Glu Gly Gly Ile Arg
                165                 170                 175     
Asn Val Leu Leu Ala Phe Ala Gly Val Ala Gly Val Gly Ala Gly Leu
            180                 185                 190         
Ala Tyr Leu Ile Arg
        195         


<210> 15
<211> 1832
<212> DNA
<213> Homo sapiens

<400> 15
gagcggccag gccagcctcg gagccagcag ggagctggga gctgggggaa acgacgccag 60
gaaagctatc gcgccagaga gggcgacggg ggctcgggaa gcctgacagg gcttttgcgc 120
acagctgccg gctggctgct acccgcccgc gccagccccc gagaacgcgc gaccaggcac 180
ccagtccggt caccgcagcg gagagctcgc cgctcgctgc agcgaggccc ggagcggccc 240
cgcagggacc ctccccagac cgcctgggcc gcccggatgt gcactaaaat ggaacagccc 300
ttctaccacg acgactcata cacagctacg ggatacggcc gggcccctgg tggcctctct 360
ctacacgact acaaactcct gaaaccgagc ctggcggtca acctggccga cccctaccgg 420
agtctcaaag cgcctggggc tcgcggaccc ggcccagagg gcggcggtgg cggcagctac 480
ttttctggtc agggctcgga caccggcgcg tctctcaagc tcgcctcttc ggagctggaa 540
cgcctgattg tccccaacag caacggcgtg atcacgacga cgcctacacc cccgggacag 600
tacttttacc cccgcggggg tggcagcggt ggaggtgcag ggggcgcagg gggcggcgtc 660
accgaggagc aggagggctt cgccgacggc tttgtcaaag ccctggacga tctgcacaag 720
atgaaccacg tgacaccccc caacgtgtcc ctgggcgcta ccggggggcc cccggctggg 780
cccgggggcg tctacgccgg cccggagcca cctcccgttt acaccaacct cagcagctac 840
tccccagcct ctgcgtcctc gggaggcgcc ggggctgccg tcgggaccgg gagctcgtac 900
ccgacgacca ccatcagcta cctcccacac gcgccgccct tcgccggtgg ccacccggcg 960
cagctgggct tgggccgcgg cgcctccacc ttcaaggagg aaccgcagac cgtgccggag 1020
gcgcgcagcc gggacgccac gccgccggtg tcccccatca acatggaaga ccaagagcgc 1080
atcaaagtgg agcgcaagcg gctgcggaac cggctggcgg ccaccaagtg ccggaagcgg 1140
aagctggagc gcatcgcgcg cctggaggac aaggtgaaga cgctcaaggc cgagaacgcg 1200
gggctgtcga gtaccgccgg cctcctccgg gagcaggtgg cccagctcaa acagaaggtc 1260
atgacccacg tcagcaacgg ctgtcagctg ctgcttgggg tcaagggaca cgccttctga 1320
acgtcccctg cccctttacg gacaccccct cgcttggacg gctgggcaca cgcctcccac 1380
tggggtccag ggagcaggcg gtgggcaccc accctgggac ctaggggcgc cgcaaaccac 1440
actggactcc ggccctccta ccctgcgccc agtccttcca cctcgacgtt tacaagcccc 1500
cccttccact tttttttgta tgtttttttt ctgctggaaa cagactcgat tcatattgaa 1560
tataatatat ttgtgtattt aacagggagg ggaagagggg gcgatcgcgg cggagctggc 1620
cccgccgcct ggtactcaag cccgcgggga cattgggaag gggacccccg ccccctgccc 1680
tcccctctct gcaccgtact gtggaaaaga aacacgcact tagtctctaa agagtttatt 1740
ttaagacgtg tttgtgtttg tgtgtgtttg ttctttttat tgaatctatt taagtaaaaa 1800
aaaaattggt tctttaaaaa aaaaaaaaaa aa                               1832

<210> 16
<211> 347
<212> PRT
<213> Homo sapiens

<400> 16
Met Cys Thr Lys Met Glu Gln Pro Phe Tyr His Asp Asp Ser Tyr Thr
 1               5                  10                  15      
Ala Thr Gly Tyr Gly Arg Ala Pro Gly Gly Leu Ser Leu His Asp Tyr
            20                  25                  30          
Lys Leu Leu Lys Pro Ser Leu Ala Val Asn Leu Ala Asp Pro Tyr Arg
        35                  40                  45              
Ser Leu Lys Ala Pro Gly Ala Arg Gly Pro Gly Pro Glu Gly Gly Gly
    50                  55                  60                  
Gly Gly Ser Tyr Phe Ser Gly Gln Gly Ser Asp Thr Gly Ala Ser Leu
65                  70                  75                  80  
Lys Leu Ala Ser Ser Glu Leu Glu Arg Leu Ile Val Pro Asn Ser Asn
                85                  90                  95      
Gly Val Ile Thr Thr Thr Pro Thr Pro Pro Gly Gln Tyr Phe Tyr Pro
            100                 105                 110         
Arg Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Val
        115                 120                 125             
Thr Glu Glu Gln Glu Gly Phe Ala Asp Gly Phe Val Lys Ala Leu Asp
    130                 135                 140                 
Asp Leu His Lys Met Asn His Val Thr Pro Pro Asn Val Ser Leu Gly
145                 150                 155                 160 
Ala Thr Gly Gly Pro Pro Ala Gly Pro Gly Gly Val Tyr Ala Gly Pro
                165                 170                 175     
Glu Pro Pro Pro Val Tyr Thr Asn Leu Ser Ser Tyr Ser Pro Ala Ser
            180                 185                 190         
Ala Ser Ser Gly Gly Ala Gly Ala Ala Val Gly Thr Gly Ser Ser Tyr
        195                 200                 205             
Pro Thr Thr Thr Ile Ser Tyr Leu Pro His Ala Pro Pro Phe Ala Gly
    210                 215                 220                 
Gly His Pro Ala Gln Leu Gly Leu Gly Arg Gly Ala Ser Thr Phe Lys
225                 230                 235                 240 
Glu Glu Pro Gln Thr Val Pro Glu Ala Arg Ser Arg Asp Ala Thr Pro
                245                 250                 255     
Pro Val Ser Pro Ile Asn Met Glu Asp Gln Glu Arg Ile Lys Val Glu
            260                 265                 270         
Arg Lys Arg Leu Arg Asn Arg Leu Ala Ala Thr Lys Cys Arg Lys Arg
        275                 280                 285             
Lys Leu Glu Arg Ile Ala Arg Leu Glu Asp Lys Val Lys Thr Leu Lys
    290                 295                 300                 
Ala Glu Asn Ala Gly Leu Ser Ser Thr Ala Gly Leu Leu Arg Glu Gln
305                 310                 315                 320 
Val Ala Gln Leu Lys Gln Lys Val Met Thr His Val Ser Asn Gly Cys
                325                 330                 335     
Gln Leu Leu Leu Gly Val Lys Gly His Ala Phe
            340                 345         


<210> 17
<211> 3662
<212> DNA
<213> Homo sapiens

<400> 17
gcgagctggt ggttgaagct ggttaaagaa cagcctaggt attccagaag tgtttgagga 60
tcccttccat gaaggaagag aggaaagttt ttaagtaaac ctcccactcc catgtgtctt 120
cagctttctt ttgcaaagga gaaaatcctt gaagtttggt aaagaccgag ttagtctatc 180
tctctttgcc tatctcgagt tgggctgggg agaggaggag ataggttctt ttgtcttttt 240
ctgtcttctc ccttccccac ttccttccct ccagtcccca ctcactcaca tgcacacact 300
aaccttggag ccgatgggat tgagtgactg gcacttggga ccacagagaa atgtcagagt 360
gtttggttac agactcaagg aaacctctca ttttagagtg ctcatttggt tttgagcaaa 420
attttggact gtgaagcaag gcattggtga agacaaaatg gcctcgccgg ctgacagctg 480
tatccagttc acccgccatg ccagtgatgt tcttctcaac cttaatcgtc tccggagtcg 540
agacatcttg actgatgttg tcattgttgt gagccgtgag cagtttagag cccataaaac 600
ggtcctcatg gcctgcagtg gcctgttcta tagcatcttt acagaccagt tgaaatgcaa 660
ccttagtgtg atcaatctag atcctgagat caaccctgag ggattctgca tcctcctgga 720
cttcatgtac acatctcggc tcaatttgcg ggagggcaac atcatggctg tgatggccac 780
ggctatgtac ctgcagatgg agcatgttgt ggacacttgc cggaagttta ttaaggccag 840
tgaagcagag atggtttctg ccatcaagcc tcctcgtgaa gagttcctca acagccggat 900
gctgatgccc caagacatca tggcctatcg gggtcgtgag gtggtggaga acaacctgcc 960
actgaggagc gcccctgggt gtgagagcag agcctttgcc cccagcctgt acagtggcct 1020
gtccacaccg ccagcctctt attccatgta cagccacctc cctgtcagca gcctcctctt 1080
ctccgatgag gagtttcggg atgtccggat gcctgtggcc aaccccttcc ccaaggagcg 1140
ggcactccca tgtgatagtg ccaggccagt ccctggtgag tacagccggc cgactttgga 1200
ggtgtccccc aatgtgtgcc acagcaatat ctattcaccc aaggaaacaa tcccagaaga 1260
ggcacgaagt gatatgcact acagtgtggc tgagggcctc aaacctgctg ccccctcagc 1320
ccgaaatgcc ccctacttcc cttgtgacaa ggccagcaaa gaagaagaga gaccctcctc 1380
ggaagatgag attgccctgc atttcgagcc ccccaatgca cccctgaacc ggaagggtct 1440
ggttagtcca cagagccccc agaaatctga ctgccagccc aactcgccca cagagtcctg 1500
cagcagtaag aatgcctgca tcctccaggc ttctggctcc cctccagcca agagccccac 1560
tgaccccaaa gcctgcaact ggaagaaata caagttcatc gtgctcaaca gcctcaacca 1620
gaatgccaaa ccagaggggc ctgagcaggc tgagctgggc cgcctttccc cacgagccta 1680
cacggcccca cctgcctgcc agccacccat ggagcctgag aaccttgacc tccagtcccc 1740
aaccaagctg agtgccagcg gggaggactc caccatccca caagccagcc ggctcaataa 1800
catcgttaac aggtccatga cgggctctcc ccgcagcagc agcgagagcc actcaccact 1860
ctacatgcac cccccgaagt gcacgtcctg cggctctcag tccccacagc atgcagagat 1920
gtgcctccac accgctggcc ccacgttccc tgaggagatg ggagagaccc agtctgagta 1980
ctcagattct agctgtgaga acggggcctt cttctgcaat gagtgtgact gccgcttctc 2040
tgaggaggcc tcactcaaga ggcacacgct gcagacccac agtgacaaac cctacaagtg 2100
tgaccgctgc caggcctcct tccgctacaa gggcaacctc gccagccaca agaccgtcca 2160
taccggtgag aaaccctatc gttgcaacat ctgtggggcc cagttcaacc ggccagccaa 2220
cctgaaaacc cacactcgaa ttcactctgg agagaagccc tacaaatgcg aaacctgcgg 2280
agccagattt gtacaggtgg cccacctccg tgcccatgtg cttatccaca ctggtgagaa 2340
gccctatccc tgtgaaatct gtggcacccg tttccggcac cttcagactc tgaagagcca 2400
cctgcgaatc cacacaggag agaaacctta ccattgtgag aagtgtaacc tgcatttccg 2460
tcacaaaagc cagctgcgac ttcacttgcg ccagaagcat ggcgccatca ccaacaccaa 2520
ggtgcaatac cgcgtgtcag ccactgacct gcctccggag ctccccaaag cctgctgaag 2580
catggagtgt tgatgctttc gtctccagcc ccttctcaga atctacccaa aggatactgt 2640
aacactttac aatgttcatc ccatgatgta gtgcctcttt catccactag tgcaaatcat 2700
agctgggggt tgggggtggt gggggtcggg gcctggggga ctgggagccg cagcagctcc 2760
ccctccccca ctgccataaa acattaagaa aatcatattg cttcttctcc tatgtgtaag 2820
gtgaaccatg tcagcaaaaa gcaaaatcat tttatatgtc aaagcagggg agtatgcaaa 2880
agttctgact tgactttagt ctgcaaaatg aggaatgtat atgttttgtg ggaacagatg 2940
tttcttttgt atgtaaatgt gcattctttt aaaagacaag acttcagtat gttgtcaaag 3000
agagggcttt aattttttta accaaaggtg aaggaatata tggcagagtt gtaaatatat 3060
aaatatatat atatataaaa taaatatata taaacctaaa aaagatatat taaaaatata 3120
aaactgcgtt aaaggctcga ttttgtatct gcaggcagac acggatctga gaatctttat 3180
tgagaaagag cacttaagag aatattttaa gtattgcatc tgtataagta agaaaatatt 3240
ttgtctaaaa tgcctcagtg tatttgtatt tttttgcaag tgaaggttta caatttacaa 3300
agtgtgtatt aaaaaaaaca aaaagaacaa aaaaatctgc agaaggaaaa atgtgtaatt 3360
ttgttctagt tttcagtttg tatatacccg tacaacgtgt cctcacggtg ccttttttca 3420
cggaagtttt caatgatggg cgagcgtgca ccatcccttt ttgaagtgta ggcagacaca 3480
gggacttgaa gttgttacta actaaactct ctttgggaat gtttgtctca tcccattctg 3540
cgtcatgctt gtgttataac tactccggag acagggtttg gctgtgtcta aactgcatta 3600
ccgcgttgta aaatatagct gtacaaatat aagaataaaa tgttgaaaag tcaaactgga 3660
aa                                                                3662

<210> 18
<211> 706
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser
 1               5                  10                  15      
Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr
            20                  25                  30          
Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr
        35                  40                  45              
Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln
    50                  55                  60                  
Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro
65                  70                  75                  80  
Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn
                85                  90                  95      
Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu
            100                 105                 110         
Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser
        115                 120                 125             
Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu
    130                 135                 140                 
Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg
145                 150                 155                 160 
Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu
                165                 170                 175     
Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro
            180                 185                 190         
Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe
        195                 200                 205             
Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe
    210                 215                 220                 
Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly
225                 230                 235                 240 
Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser
                245                 250                 255     
Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp
            260                 265                 270         
Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala
        275                 280                 285             
Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu
    290                 295                 300                 
Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn
305                 310                 315                 320 
Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys
                325                 330                 335     
Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn
            340                 345                 350         
Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr
        355                 360                 365             
Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn
    370                 375                 380                 
Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu
385                 390                 395                 400 
Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro
                405                 410                 415     
Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser
            420                 425                 430         
Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn
        435                 440                 445             
Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser
    450                 455                 460                 
His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser
465                 470                 475                 480 
Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr
                485                 490                 495     
Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser
            500                 505                 510         
Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser
        515                 520                 525             
Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys
    530                 535                 540                 
Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn
545                 550                 555                 560 
Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys
                565                 570                 575     
Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His
            580                 585                 590         
Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly
        595                 600                 605             
Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His
    610                 615                 620                 
Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg
625                 630                 635                 640 
His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys
                645                 650                 655     
Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln
            660                 665                 670         
Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys
        675                 680                 685             
Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys
    690                 695                 700                 
Ala Cys
705     


<210> 19
<211> 2104
<212> DNA
<213> Homo sapiens

<400> 19
acgtagcgcg gcgctcggaa ctgacctact aacacacatc tctccgcgcg gccacggcgc 60
ccgcggaccc ggcgcgcccg cccgcctccc gcgccgcgcc ctcgccgccg cccgcctccc 120
gccgcggccc cggaggcccg gcccggcccg agccccgagc gccggcggcc cgactcccgg 180
ccgccccttt ctttctcctc gccggcccga gagcaggaac acgataacga aggaggccca 240
acttcattca ataaggagcc tgacggattt atcccagacg gtagaacaaa aggaagaata 300
ttgatggatt ttaaaccaga gtttttaaag agcttgagaa tacggggaaa ttaatttgtt 360
ctcctacaca catagatagg gtaaggttgt ttctgatgca gctgagaaaa atgcagaccg 420
tcaaaaagga gcaggcgtct cttgatgcca gtagcaatgt ggacaagatg atggtcctta 480
attctgcttt aacggaagtg tcagaagact ccacaacagg tgaggagctg cttctcagtg 540
aaggaagtgt ggggaagaac aaatcttctg catgtcggag gaaacgggaa ttcattcctg 600
atgaaaagaa agatgctatg tattgggaaa aaaggcggaa aaataatgaa gctgccaaaa 660
gatctcgtga gaagcgtcga ctgaatgacc tggttttaga gaacaaacta attgcactgg 720
gagaagaaaa cgccacttta aaagctgagc tgctttcact aaaattaaag tttggtttaa 780
ttagctccac agcatatgct caagagattc agaaactcag taattctaca gctgtgtact 840
ttcaagatta ccagacttcc aaatccaatg tgagttcatt tgtggacgag cacgaaccct 900
cgatggtgtc aagtagttgt atttctgtca ttaaacactc tccacaaagc tcgctgtccg 960
atgtttcaga agtgtcctca gtagaacaca cgcaggagag ctctgtgcag ggaagctgca 1020
gaagtcctga aaacaagttc cagattatca agcaagagcc gatggaatta gagagctaca 1080
caagggagcc aagagatgac cgaggctctt acacagcgtc catctatcaa aactatatgg 1140
ggaattcttt ctctgggtac tcacactctc ccccactact gcaagtcaac cgatcctcca 1200
gcaactcccc gagaacgtcg gaaactgatg atggtgtggt aggaaagtca tctgatggag 1260
aagacgagca acaggtcccc aagggcccca tccattctcc agttgaactc aagcatgtgc 1320
atgcaactgt ggttaaagtt ccagaagtga attcctctgc cttgccacac aagctccgga 1380
tcaaagccaa agccatgcag atcaaagtag aagcctttga taatgaattt gaggccacgc 1440
aaaaactttc ctcacctatt gacatgacat ctaaaagaca tttcgaactc gaaaagcata 1500
gtgccccaag tatggtacat tcttctctta ctcctttctc agtgcaagtg actaacattc 1560
aagattggtc tctcaaatcg gagcactggc atcaaaaaga actgagtggc aaaactcaga 1620
atagtttcaa aactggagtt gttgaaatga aagacagtgg ctacaaagtt tctgacccag 1680
agaacttgta tttgaagcag gggatagcaa acttatctgc agaggttgtc tcactcaaga 1740
gacttatagc cacacaacca atctctgctt cagactctgg gtaaattact actgagtaag 1800
agctgggcat ttagaaagat gtcatttgca atagagcagt ccattttgta ttatgctgaa 1860
ttttcactgg acctgtgatg tcatttcact gtgatgtgca catgttgtct gtttggtgtc 1920
tttttgtgca cagattatga tgaagattag attgtgttat cactctgcct gtgtatagtc 1980
agatagtcca tgcgaaggct gtatatattg aacattattt ttgttgttct attataaagt 2040
gtgtaagtta ccagtttcaa taaaggattg gtgacaaaca cagaaaaaaa aaaaaaaaaa 2100
aaaa                                                              2104

<210> 20
<211> 462
<212> PRT
<213> Homo sapiens

<400> 20
Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu
 1               5                  10                  15      
Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu
            20                  25                  30          
Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Glu Leu Leu Leu Ser
        35                  40                  45              
Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg
    50                  55                  60                  
Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg
65                  70                  75                  80  
Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu
                85                  90                  95      
Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn
            100                 105                 110         
Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu
        115                 120                 125             
Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser
    130                 135                 140                 
Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser
145                 150                 155                 160 
Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile
                165                 170                 175     
Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu
            180                 185                 190         
Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys
        195                 200                 205             
Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu
    210                 215                 220                 
Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr
225                 230                 235                 240 
Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser
                245                 250                 255     
His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro
            260                 265                 270         
Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly
        275                 280                 285             
Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu
    290                 295                 300                 
Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser
305                 310                 315                 320 
Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile
                325                 330                 335     
Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser
            340                 345                 350         
Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His
        355                 360                 365             
Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln
    370                 375                 380                 
Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln
385                 390                 395                 400 
Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val
                405                 410                 415     
Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr
            420                 425                 430         
Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys
        435                 440                 445             
Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly
    450                 455                 460         


<210> 21
<211> 3270
<212> DNA
<213> Homo sapiens

<400> 21
actcagactc tgatggctct gtagctaact ggcccatcct cagagactaa cgcaaaggaa 60
cgaatttcca ggatgttcga ctatgtggag aaaacaaaaa aaaagcaaag aaaaaaatat 120
ttttaaagaa agaaagaagg ccaggtgcag tggctcacgc ctgtaatccc aacactttgg 180
gaggccgagg cagacagatc acctgaggtc aggagttcaa gaccagcctg gccaacatgg 240
agatctgcgc tgacccccag tttatcattg gaggagccac ccgcacagac atctgccaag 300
gagccctggg tgactgctgg ctgctggcag ccattgcctc cctcaccttg aatgaagaaa 360
tcctggctcg agtcgtcccc ctaaaccaga gcttccagga aaactatgca gggatctttc 420
acttccagtt ctggcaatac ggcgagtggg tggaggtggt ggtggatgac aggctgccca 480
ccaaggacgg ggagctgctc tttgtgcatt cagccgaagg gagcgagttc tggagcgccc 540
tgctggagaa ggcatacgcc aagatcaacg gatgctatga agcgctatca gggggtgcca 600
ccactgaggg cttcgaagac ttcaccggag gcattgctga gtggtatgag ttgaagaagc 660
cccctcccaa cctgttcaag atcatccaga aagctctgca aaaaggctct ctccttggct 720
gctccatcga catcaccagc gccgcggact cggaggccat cacgtttcag aagctggtga 780
aggggcacgc gtactcggtc accggagccg aggaggttga aagtaacgga agcctacaga 840
aactgatccg catccgaaat ccctggggag aagtggagtg gacagggcgg tggaatgaca 900
actgcccaag ctggaacact atagacccag aggagaggga aaggctgacc agacggcatg 960
aagatggaga attctggatg tctttcagtg acttcctgag gcactattcc cgcctggaga 1020
tctgtaacct gaccccagac actctcacca gcgataccta caagaagtgg aaactcacca 1080
aaatggatgg gaactggagg cggggctcca ccgcgggagg ttgcaggaac tacccgaaca 1140
cattctggat gaaccctcag tacctgatca agctggagga ggaggatgag gacgaggagg 1200
atggggagag cggctgcacc ttcctggtgg ggctcattca gaagcaccga cggcggcaga 1260
ggaagatggg cgaggacatg cacaccatcg gctttggcat ctatgaggtt ccagaggagt 1320
taagtgggca gaccaacatc cacctcagca aaaacttctt cctgacgaat cgcgccaggg 1380
agcgctcaga caccttcatc aacctccggg aggtgctcaa ccgcttcaag ctgccgccag 1440
gagagtacat tctcgtgcct tccaccttcg aacccaacaa ggatggggat ttctgcatcc 1500
gggtcttttc tgaaaagaaa gctgactacc aagctgtcga tgatgaaatc gaggccaatc 1560
ttgaagagtt cgacatcagc gaggatgaca ttgatgatgg attcaggaga ctgtttgccc 1620
agttggcagg agaggatgcg gagatctctg cctttgagct gcagaccatc ctgagaaggg 1680
ttctagcaaa gcgccaagat atcaagtcag atggcttcag catcgagaca tgcaaaatta 1740
tggttgacat gctagattcg gacgggagtg gcaagctggg gctgaaggag ttctacattc 1800
tctggacgaa gattcaaaaa taccaaaaaa tttaccgaga aatcgacgtt gacaggtctg 1860
gtaccatgaa ttcctatgaa atgcggaagg cattagaaga agcaggtttc aagatgccct 1920
gtcaactcca ccaagtcatc gttgctcggt ttgcagatga ccagctcatc atcgattttg 1980
ataattttgt tcggtgtttg gttcggctgg aaacgctatt caagatattt aagcagctgg 2040
atcccgagaa tactggaaca atagagctcg accttatctc ttggctctgt ttctcagtac 2100
tttgaagtta taactaatct gcctgaagac ttctcatgat ggaaaatcag ccaaggacta 2160
agcttccata gaaatacact ttgtatctgg acctcaaaat tatgggaaca tttacttaaa 2220
cggatgatca tagctgaaaa taatgatact gtcaatttga gatagcagaa gtttcacaca 2280
tcaaagtaaa agatttgcat atcattatac taaatgcaaa tgagtcgctt aacccttgac 2340
aaggtcaaag aaagctttaa atctgtaaat agtatacact ttttactttt acacactttc 2400
ctgttcatag caatattaaa tcaggaaaaa aaaatgcagg gaggtattta acagctgagc 2460
aaaaacattg agtcgctctc aaaggacacg aggcccttgg cagggaatat ttaaagcaac 2520
ttcaagttta aaatgcagct gttgattcta ccaaacaaca gtccaagatt accatttccc 2580
atgagccaac tgggaaacat ggtatatcat gaagtaatct tgtcaaggca tctggagagt 2640
ccaggagaga agactcacct ctgtcgcttg ggttaaacaa gagacaggtt ttgtagaata 2700
ttgattggta atagtaaatc gttctcctta caatcaagtt cttgacccta ttcggcctta 2760
tacatctggt cttacaaaga ccaaagggat cctgcgcttg atcaactgaa ccagtatgcc 2820
aaaaccaggc atccaatttg taaaccaatt atgataaagg acaaaataag ctgtttgcca 2880
cctcaaaact ttatgaactt caccaccact agtgtctgtc catggagtta gaggggacat 2940
cacttagaag ttcttataga aaggacacaa gtttgtttcc tggctttacc ttgggaaaat 3000
gctagcaaca ttatagaaat tttgccttgt tgccttatct tcttccaaat gtactgttaa 3060
ataaaaataa agggttaccc catgcaatca caccatgcca tgttttcctt cctggagggc 3120
agccccacag gacggtttat gagcacacaa ttatagcttg tttctacttt aacaaggtat 3180
gctgcctctg taaattcatg tattcaaagg aaaagacacc ttgcctataa ttaaaatgtg 3240
gaactataaa attttttaaa atccaaaaaa                                  3270

<210> 22
<211> 622
<212> PRT
<213> Homo sapiens

<400> 22
Met Glu Ile Cys Ala Asp Pro Gln Phe Ile Ile Gly Gly Ala Thr Arg
 1               5                  10                  15      
Thr Asp Ile Cys Gln Gly Ala Leu Gly Asp Cys Trp Leu Leu Ala Ala
            20                  25                  30          
Ile Ala Ser Leu Thr Leu Asn Glu Glu Ile Leu Ala Arg Val Val Pro
        35                  40                  45              
Leu Asn Gln Ser Phe Gln Glu Asn Tyr Ala Gly Ile Phe His Phe Gln
    50                  55                  60                  
Phe Trp Gln Tyr Gly Glu Trp Val Glu Val Val Val Asp Asp Arg Leu
65                  70                  75                  80  
Pro Thr Lys Asp Gly Glu Leu Leu Phe Val His Ser Ala Glu Gly Ser
                85                  90                  95      
Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Ile Asn Gly
            100                 105                 110         
Cys Tyr Glu Ala Leu Ser Gly Gly Ala Thr Thr Glu Gly Phe Glu Asp
        115                 120                 125             
Phe Thr Gly Gly Ile Ala Glu Trp Tyr Glu Leu Lys Lys Pro Pro Pro
    130                 135                 140                 
Asn Leu Phe Lys Ile Ile Gln Lys Ala Leu Gln Lys Gly Ser Leu Leu
145                 150                 155                 160 
Gly Cys Ser Ile Asp Ile Thr Ser Ala Ala Asp Ser Glu Ala Ile Thr
                165                 170                 175     
Phe Gln Lys Leu Val Lys Gly His Ala Tyr Ser Val Thr Gly Ala Glu
            180                 185                 190         
Glu Val Glu Ser Asn Gly Ser Leu Gln Lys Leu Ile Arg Ile Arg Asn
        195                 200                 205             
Pro Trp Gly Glu Val Glu Trp Thr Gly Arg Trp Asn Asp Asn Cys Pro
    210                 215                 220                 
Ser Trp Asn Thr Ile Asp Pro Glu Glu Arg Glu Arg Leu Thr Arg Arg
225                 230                 235                 240 
His Glu Asp Gly Glu Phe Trp Met Ser Phe Ser Asp Phe Leu Arg His
                245                 250                 255     
Tyr Ser Arg Leu Glu Ile Cys Asn Leu Thr Pro Asp Thr Leu Thr Ser
            260                 265                 270         
Asp Thr Tyr Lys Lys Trp Lys Leu Thr Lys Met Asp Gly Asn Trp Arg
        275                 280                 285             
Arg Gly Ser Thr Ala Gly Gly Cys Arg Asn Tyr Pro Asn Thr Phe Trp
    290                 295                 300                 
Met Asn Pro Gln Tyr Leu Ile Lys Leu Glu Glu Glu Asp Glu Asp Glu
305                 310                 315                 320 
Glu Asp Gly Glu Ser Gly Cys Thr Phe Leu Val Gly Leu Ile Gln Lys
                325                 330                 335     
His Arg Arg Arg Gln Arg Lys Met Gly Glu Asp Met His Thr Ile Gly
            340                 345                 350         
Phe Gly Ile Tyr Glu Val Pro Glu Glu Leu Ser Gly Gln Thr Asn Ile
        355                 360                 365             
His Leu Ser Lys Asn Phe Phe Leu Thr Asn Arg Ala Arg Glu Arg Ser
    370                 375                 380                 
Asp Thr Phe Ile Asn Leu Arg Glu Val Leu Asn Arg Phe Lys Leu Pro
385                 390                 395                 400 
Pro Gly Glu Tyr Ile Leu Val Pro Ser Thr Phe Glu Pro Asn Lys Asp
                405                 410                 415     
Gly Asp Phe Cys Ile Arg Val Phe Ser Glu Lys Lys Ala Asp Tyr Gln
            420                 425                 430         
Ala Val Asp Asp Glu Ile Glu Ala Asn Leu Glu Glu Phe Asp Ile Ser
        435                 440                 445             
Glu Asp Asp Ile Asp Asp Gly Phe Arg Arg Leu Phe Ala Gln Leu Ala
    450                 455                 460                 
Gly Glu Asp Ala Glu Ile Ser Ala Phe Glu Leu Gln Thr Ile Leu Arg
465                 470                 475                 480 
Arg Val Leu Ala Lys Arg Gln Asp Ile Lys Ser Asp Gly Phe Ser Ile
                485                 490                 495     
Glu Thr Cys Lys Ile Met Val Asp Met Leu Asp Ser Asp Gly Ser Gly
            500                 505                 510         
Lys Leu Gly Leu Lys Glu Phe Tyr Ile Leu Trp Thr Lys Ile Gln Lys
        515                 520                 525             
Tyr Gln Lys Ile Tyr Arg Glu Ile Asp Val Asp Arg Ser Gly Thr Met
    530                 535                 540                 
Asn Ser Tyr Glu Met Arg Lys Ala Leu Glu Glu Ala Gly Phe Lys Met
545                 550                 555                 560 
Pro Cys Gln Leu His Gln Val Ile Val Ala Arg Phe Ala Asp Asp Gln
                565                 570                 575     
Leu Ile Ile Asp Phe Asp Asn Phe Val Arg Cys Leu Val Arg Leu Glu
            580                 585                 590         
Thr Leu Phe Lys Ile Phe Lys Gln Leu Asp Pro Glu Asn Thr Gly Thr
        595                 600                 605             
Ile Glu Leu Asp Leu Ile Ser Trp Leu Cys Phe Ser Val Leu
    610                 615                 620         


<210> 23
<211> 3136
<212> DNA
<213> Homo sapiens

<400> 23
gcgcagaact tggggagccg ccgccgccat ccgccgccgc agccagcttc cgccgccgca 60
ggaccggccc ctgccccagc ctccgcagcc gcggcgcgtc cacgcccgcc cgcgcccagg 120
gcgagtcggg gtcgccgcct gcacgcttct cagtgttccc cgcgccccgc atgtaacccg 180
gccaggcccc cgcaactgtg tcccctgcag ctccagcccc gggctgcacc cccccgcccc 240
gacaccagct ctccagcctg ctcgtccagg atggccgcgg ccaaggccga gatgcagctg 300
atgtccccgc tgcagatctc tgacccgttc ggatcctttc ctcactcgcc caccatggac 360
aactacccta agctggagga gatgatgctg ctgagcaacg gggctcccca gttcctcggc 420
gccgccgggg ccccagaggg cagcggcagc aacagcagca gcagcagcag cgggggcggt 480
ggaggcggcg ggggcggcag caacagcagc agcagcagca gcaccttcaa ccctcaggcg 540
gacacgggcg agcagcccta cgagcacctg accgcagagt cttttcctga catctctctg 600
aacaacgaga aggtgctggt ggagaccagt taccccagcc aaaccactcg actgcccccc 660
atcacctata ctggccgctt ttccctggag cctgcaccca acagtggcaa caccttgtgg 720
cccgagcccc tcttcagctt ggtcagtggc ctagtgagca tgaccaaccc accggcctcc 780
tcgtcctcag caccatctcc agcggcctcc tccgcctccg cctcccagag cccacccctg 840
agctgcgcag tgccatccaa cgacagcagt cccatttact cagcggcacc caccttcccc 900
acgccgaaca ctgacatttt ccctgagcca caaagccagg ccttcccggg ctcggcaggg 960
acagcgctcc agtacccgcc tcctgcctac cctgccgcca agggtggctt ccaggttccc 1020
atgatccccg actacctgtt tccacagcag cagggggatc tgggcctggg caccccagac 1080
cagaagccct tccagggcct ggagagccgc acccagcagc cttcgctaac ccctctgtct 1140
actattaagg cctttgccac tcagtcgggc tcccaggacc tgaaggccct caataccagc 1200
taccagtccc agctcatcaa acccagccgc atgcgcaagt accccaaccg gcccagcaag 1260
acgccccccc acgaacgccc ttacgcttgc ccagtggagt cctgtgatcg ccgcttctcc 1320
cgctccgacg agctcacccg ccacatccgc atccacacag gccagaagcc cttccagtgc 1380
cgcatctgca tgcgcaactt cagccgcagc gaccacctca ccacccacat ccgcacccac 1440
acaggcgaaa agcccttcgc ctgcgacatc tgtggaagaa agtttgccag gagcgatgaa 1500
cgcaagaggc ataccaagat ccacttgcgg cagaaggaca agaaagcaga caaaagtgtt 1560
gtggcctctt cggccacctc ctctctctct tcctacccgt ccccggttgc tacctcttac 1620
ccgtccccgg ttactacctc ttatccatcc ccggccacca cctcataccc atcccctgtg 1680
cccacctcct tctcctctcc cggctcctcg acctacccat cccctgtgca cagtggcttc 1740
ccctccccgt cggtggccac cacgtactcc tctgttcccc ctgctttccc ggcccaggtc 1800
agcagcttcc cttcctcagc tgtcaccaac tccttcagcg cctccacagg gctttcggac 1860
atgacagcaa ccttttctcc caggacaatt gaaatttgct aaagggaaag gggaaagaaa 1920
gggaaaaggg agaaaaagaa acacaagaga cttaaaggac aggaggagga gatggccata 1980
ggagaggagg gttcctctta ggtcagatgg aggttctcag agccaagtcc tccctctcta 2040
ctggagtgga aggtctattg gccaacaatc ctttctgccc acttcccctt ccccaattac 2100
tattcccttt gacttcagct gcctgaaaca gccatgtcca agttcttcac ctctatccaa 2160
agaacttgat ttgcatggat tttggataaa tcatttcagt atcatctcca tcatatgcct 2220
gaccccttgc tcccttcaat gctagaaaat cgagttggca aaatggggtt tgggcccctc 2280
agagccctgc cctgcaccct tgtacagtgt ctgtgccatg gatttcgttt ttcttggggt 2340
actcttgatg tgaagataat ttgcatattc tattgtatta tttggagtta ggtcctcact 2400
tgggggaaaa aaaaaaaaga aaagccaagc aaaccaatgg tgatcctcta ttttgtgatg 2460
atgctgtgac aataagtttg aacctttttt tttgaaacag cagtcccagt attctcagag 2520
catgtgtcag agtgttgttc cgttaacctt tttgtaaata ctgcttgacc gtactctcac 2580
atgtggcaaa atatggtttg gtttttcttt tttttttttt ttgaaagtgt tttttcttcg 2640
tccttttggt ttaaaaagtt tcacgtcttg gtgccttttg tgtgatgcgc cttgctgatg 2700
gcttgacatg tgcaattgtg agggacatgc tcacctctag ccttaagggg ggcagggagt 2760
gatgatttgg gggaggcttt gggagcaaaa taaggaagag ggctgagctg agcttcggtt 2820
ctccagaatg taagaaaaca aaatctaaaa caaaatctga actctcaaaa gtctattttt 2880
ttaactgaaa atgtaaattt ataaatatat tcaggagttg gaatgttgta gttacctact 2940
gagtaggcgg cgatttttgt atgttatgaa catgcagttc attattttgt ggttctattt 3000
tactttgtac ttgtgtttgc ttaaacaaag tgactgtttg gcttataaac acattgaatg 3060
cgctttattg cccatgggat atgtggtgta tatccttcca aaaaattaaa acgaaaataa 3120
agtagctgcg attggg                                                 3136

<210> 24
<211> 543
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Ala Ala Lys Ala Glu Met Gln Leu Met Ser Pro Leu Gln Ile
 1               5                  10                  15      
Ser Asp Pro Phe Gly Ser Phe Pro His Ser Pro Thr Met Asp Asn Tyr
            20                  25                  30          
Pro Lys Leu Glu Glu Met Met Leu Leu Ser Asn Gly Ala Pro Gln Phe
        35                  40                  45              
Leu Gly Ala Ala Gly Ala Pro Glu Gly Ser Gly Ser Asn Ser Ser Ser
    50                  55                  60                  
Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Asn Ser Ser
65                  70                  75                  80  
Ser Ser Ser Ser Thr Phe Asn Pro Gln Ala Asp Thr Gly Glu Gln Pro
                85                  90                  95      
Tyr Glu His Leu Thr Ala Glu Ser Phe Pro Asp Ile Ser Leu Asn Asn
            100                 105                 110         
Glu Lys Val Leu Val Glu Thr Ser Tyr Pro Ser Gln Thr Thr Arg Leu
        115                 120                 125             
Pro Pro Ile Thr Tyr Thr Gly Arg Phe Ser Leu Glu Pro Ala Pro Asn
    130                 135                 140                 
Ser Gly Asn Thr Leu Trp Pro Glu Pro Leu Phe Ser Leu Val Ser Gly
145                 150                 155                 160 
Leu Val Ser Met Thr Asn Pro Pro Ala Ser Ser Ser Ser Ala Pro Ser
                165                 170                 175     
Pro Ala Ala Ser Ser Ala Ser Ala Ser Gln Ser Pro Pro Leu Ser Cys
            180                 185                 190         
Ala Val Pro Ser Asn Asp Ser Ser Pro Ile Tyr Ser Ala Ala Pro Thr
        195                 200                 205             
Phe Pro Thr Pro Asn Thr Asp Ile Phe Pro Glu Pro Gln Ser Gln Ala
    210                 215                 220                 
Phe Pro Gly Ser Ala Gly Thr Ala Leu Gln Tyr Pro Pro Pro Ala Tyr
225                 230                 235                 240 
Pro Ala Ala Lys Gly Gly Phe Gln Val Pro Met Ile Pro Asp Tyr Leu
                245                 250                 255     
Phe Pro Gln Gln Gln Gly Asp Leu Gly Leu Gly Thr Pro Asp Gln Lys
            260                 265                 270         
Pro Phe Gln Gly Leu Glu Ser Arg Thr Gln Gln Pro Ser Leu Thr Pro
        275                 280                 285             
Leu Ser Thr Ile Lys Ala Phe Ala Thr Gln Ser Gly Ser Gln Asp Leu
    290                 295                 300                 
Lys Ala Leu Asn Thr Ser Tyr Gln Ser Gln Leu Ile Lys Pro Ser Arg
305                 310                 315                 320 
Met Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Pro His Glu Arg
                325                 330                 335     
Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser
            340                 345                 350         
Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe
        355                 360                 365             
Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr
    370                 375                 380                 
Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile
385                 390                 395                 400 
Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys
                405                 410                 415     
Ile His Leu Arg Gln Lys Asp Lys Lys Ala Asp Lys Ser Val Val Ala
            420                 425                 430         
Ser Ser Ala Thr Ser Ser Leu Ser Ser Tyr Pro Ser Pro Val Ala Thr
        435                 440                 445             
Ser Tyr Pro Ser Pro Val Thr Thr Ser Tyr Pro Ser Pro Ala Thr Thr
    450                 455                 460                 
Ser Tyr Pro Ser Pro Val Pro Thr Ser Phe Ser Ser Pro Gly Ser Ser
465                 470                 475                 480 
Thr Tyr Pro Ser Pro Val His Ser Gly Phe Pro Ser Pro Ser Val Ala
                485                 490                 495     
Thr Thr Tyr Ser Ser Val Pro Pro Ala Phe Pro Ala Gln Val Ser Ser
            500                 505                 510         
Phe Pro Ser Ser Ala Val Thr Asn Ser Phe Ser Ala Ser Thr Gly Leu
        515                 520                 525             
Ser Asp Met Thr Ala Thr Phe Ser Pro Arg Thr Ile Glu Ile Cys
    530                 535                 540             


<210> 25
<211> 3677
<212> DNA
<213> Homo sapiens

<400> 25
tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag 60
cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg 120
ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa 180
catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca 240
cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt 300
ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga 360
gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg 420
agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc 480
cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac 540
cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg 600
gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt 660
ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc 720
gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag 780
ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg 840
aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc 900
gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc 960
gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc 1020
ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg 1080
ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg 1140
cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca 1200
atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag 1260
ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt 1320
gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc 1380
cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa 1440
gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag 1500
cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg 1560
ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg 1620
tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag 1680
gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc 1740
gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac 1800
tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag 1860
aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt 1920
gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc 1980
tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat 2040
tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat 2100
atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata 2160
tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac 2220
tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag 2280
gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct 2340
cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa 2400
caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga 2460
cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg 2520
acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc 2580
actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt 2640
gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc 2700
agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg 2760
gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc 2820
aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct 2880
tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga 2940
aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa 3000
acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt 3060
caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg 3120
tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc 3180
ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc 3240
cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg 3300
gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat 3360
aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa 3420
ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg 3480
gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc 3540
tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa 3600
tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca 3660
aaaaaaaaaa aaaaaaa                                                3677

<210> 26
<211> 412
<212> PRT
<213> Homo sapiens

<400> 26
Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu
 1               5                  10                  15      
Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln
            20                  25                  30          
Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg
        35                  40                  45              
Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe
    50                  55                  60                  
Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala
65                  70                  75                  80  
Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu
                85                  90                  95      
Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly
            100                 105                 110         
Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp
        115                 120                 125             
Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly
    130                 135                 140                 
Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro
145                 150                 155                 160 
His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg
                165                 170                 175     
Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu
            180                 185                 190         
Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro
        195                 200                 205             
Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met
    210                 215                 220                 
Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp
225                 230                 235                 240 
Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser
                245                 250                 255     
Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu
            260                 265                 270         
Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg
        275                 280                 285             
Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln
    290                 295                 300                 
His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu
305                 310                 315                 320 
Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys
                325                 330                 335     
Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys
            340                 345                 350         
Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser
        355                 360                 365             
Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys
    370                 375                 380                 
Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu
385                 390                 395                 400 
Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg
                405                 410         


<210> 27
<211> 5093
<212> DNA
<213> Homo sapiens

<400> 27
aaagatgacc gtggttaagg cagtagaaag caggctcgac actgagacgc ggttccagcc 60
ctagaaggat tgcattttac gattcaggca aacttcgagt ctcctcatgt gacatgtgtg 120
cactcctgga ccgttttaat tatgagaaac gtggtttgca gcatgattcc ttccagtcga 180
taaatcggaa tctctctcgc tcccacccct tcttaacttc aggcttcctg catcccggag 240
cactcccggc agccccttcc ctcccccgcc ccggggatgc tccgactcgg cgcttagcca 300
ttcatcaacc ggttcacacc ggcggcggcc gccgcggagt gacgtccgga gggggcgggc 360
ctccgccccc gcctgtcggc tcctggcccg cggttccagg ccgcgattgg tggctggagg 420
gttgcacgtc gcgccggcta taaaggggag ggcttgtgac gcaagggcgc ctcggcgcgt 480
gtattggctc cttcggctgc gggccggctc ggctacgcgc tctgctccga gccgctcact 540
gcatggtaga gtctggtgcc cccgccgccg cctgcatcgc cgccaccgcc gctccgccac 600
gaccaccgcc gcctcctgcc ctgcagccac cgccaccgcc tgtgtcgccg ccgcctcggg 660
accggctgta tgattaggcc acaatcttca atgagtaaac atattcctca attctgtggt 720
gttcttggtc acacatttat ggagtttctg aagggcagtg gagattactg ccaggcacag 780
cacgacctct atgcagacaa gtgaactgta gaaactgatt actgctccac caagaagccc 840
ccataagagt ggttatcctg gacacagaag tgttgaattg aaatccacag agcattttac 900
aagagttctg acctggatgg ggtaaacctc agtgcacttc ttttctgttg gcctcagtat 960
tactggattg aagaattgct gcttcttgtt aggaggttca tttcacttat cattacttac 1020
aacttcatac tcaaagcact gagaatttca agtggagtat attgaagtag acttcagttt 1080
ctttgcatca tttctgtatt caattttttt aattatttca taaccctatt gagtgttttt 1140
taactaaatt aacatggctc gaatgaaccg cccagctcct gtggaagtca catacaagaa 1200
catgagattt cttattacac acaatccaac caatgcgacc ttaaacaaat ttatagagga 1260
acttaagaag tatggagtta ccacaatagt aagagtatgt gaagcaactt atgacactac 1320
tcttgtggag aaagaaggta tccatgttct tgattggcct tttgatgatg gtgcaccacc 1380
atccaaccag attgttgatg actggttaag tcttgtgaaa attaagtttc gtgaagaacc 1440
tggttgttgt attgctgttc attgcgttgc aggccttggg agagctccag tacttgttgc 1500
cctagcatta attgaaggtg gaatgaaata cgaagatgca gtacaattca taagacaaaa 1560
gcggcgtgga gcttttaaca gcaagcaact tctgtatttg gagaagtatc gtcctaaaat 1620
gcggctgcgt ttcaaagatt ccaacggtca tagaaacaac tgttgcattc aataaaattg 1680
gggtgcctaa tgctactgga agtggaactt gagatagggc ctaatttgtt atacatatta 1740
gccaacatgt tggcttagta agtctaatga agcttccata ggagtattga aaggcagttt 1800
taccaggcct caagctagac agatttggca acctctgtat ttgggttaca gtcaacctat 1860
ttggatactt ggcaaaagat tcttgctgtc agcatataaa atgtgcttgt catttgtatc 1920
aattgacctt tccccaaatc atgcagtatt gagttatgac ttgttaaatc tattcccatg 1980
ccagaatctt atcaatacat aagaaattta ggaagattag gtgccaaaat acccagcaca 2040
atacttgtat atttttagta ccatacagaa gtaaaatccc aggaactatg aacactagac 2100
cttatgtggt ttattccttc aatcatttca aacattgaaa gtagggccta catggttatt 2160
tgcctgctca ctttatgttt acatctccca cattcatacc aatatacgtc aggtttgctt 2220
aaccattgat tttttttttt ttttaccaag tcttacagtg attattttac gtgtttccat 2280
gtatctcact ttgtgctgta ttaaaaaaac ctccattttg aaaatctacg ttgtacagaa 2340
gcacatgtct ttaatgtctt cagacaaaaa agccttacat taatttaatg tttgcactct 2400
gaggtgcaac ttaacaggga gggcctgaga aaagaatggg agggggctat taattatttt 2460
tagcaaaatg ttgcctttgt cttgtgcaaa catgtagaat atgctcttta atttagtaaa 2520
atattttttt aaaaggtaga gatgctttgt tattgtaatc ataaacttcc tgaaattctt 2580
gtaatttttt tcccatactt atcagaagtg tgtttaccaa cttatttttg tttgaaagtg 2640
tgattttttt tttccttccc aacctctctt gcaaaaaaag aaatgggttt ctgctaatga 2700
attgagcaga catctaatat tttatatgcc ttttgagctg tgtaacttaa tatttggata 2760
cttgacaatt tgttttatta tgtaattgat aaaatggtga tgtgtattaa tgttagttca 2820
accatatatt tatactgtct ggggatgtgt ggttatagtt ctgtgggaga aataattttg 2880
tcagtgttca ccagcttgta aaaacttagt gcgagagctg aaacatctaa ataaataatg 2940
acatgcattt atcatcattg agattggttt gcttaaaatt aacttatttt gtagaagaca 3000
aaatgaattg cacttcactt aatgtgtgtc ctcatctttt tacaaataaa tgaaggatta 3060
taaatgatgt cagcatttta gtaaactttt agacaaaatt tgttagggtc attcatgaaa 3120
actttaatac taaaagcact ttccattata tactttttaa aggtctagat aattttgaac 3180
caatttatta ttgtgtactg aggagaaata atgtatagta gaggacagcc ttggtttgta 3240
aagctcagtt ccactagttc atggttttgt gcaacttctg agcctcagtt ttctcctttg 3300
caaattaata attacatacc tttatagatt ttgaaattaa tttaaatatt agtatttggt 3360
acatgaaggc ttaatgttaa gtttccttta atgatccaca ataatccctt tgatcacgtt 3420
aatctaaatc tagatgtctt tgtctaattt tttttgaata gcagttataa atgtaaagga 3480
ctcaaagttt aagtaaaaag tgatactcca ccttgtgttt caaagaattt agttccacct 3540
cttcatacca gtttaacact taatatattt cattggattt tagacagggc aaaaggaaga 3600
acaggggcct ctggaggccc ttggttattt aaatcttgga ttatttgtga tagtaatcac 3660
aaatttttgg ctaattttta acctgaggtt ttgttttttt tttaaaggaa atgcagccta 3720
gtcttgagaa cataatttta tataatcaat tactaaatgt taaactatta ccacacagcc 3780
cataaaacag catttgcgtt tattgagaga gaggatgtgc catcatgatt aatgaaaact 3840
atcttttgag tttgaaaaga aattaatttg cagtgtttgg attgtatata tggtgctaaa 3900
aataaattaa tttactttat aaaccttatc tgtacattat acgatgtgat gaaatttgct 3960
ttttatccaa atattttgta tcttgtaaat atggctaatt ataggaatgc ctataataca 4020
tcttagattc cttatatcta ataagagttc aaagagttat gagttgaagt cttgaatgca 4080
ggaaactatc tgatagtgtt ctaaaatttg gttacttggg tttggatacc cttagtggga 4140
tgatgtaaat agaggctagc tacctaggct tgtctatagc aaccataatg ttgatgtaag 4200
taatgcggtt actgaatcat aagaaaatgc catctctttt tagttgaagg aaaactctgg 4260
aagtaggtgc cattggtcat tctgcagtgc actgcaacca ttgtttcccc tagtgccctc 4320
ttttccctag ggcattgctc tcctattccc acgccttaac acagctctat acctagaagc 4380
agccagccca ggcatgcagt cacatttaat cacatccccc ttctagagtg cttcaaaatg 4440
atgtagtccc tcaacttggc taaagaatct caatctcttg aaatttattt ttttaatgtc 4500
atattcatct ggtaaatatc tactgtttgc caggcattta agaatatggc aaagaacata 4560
aaagatggtg tcaccagatt ttggtcacca atgagtaccc gacccgttgc catgattaag 4620
agagaatgct ttctattgga gtttcaggaa atataatttg agaatacttt aaagggaagt 4680
ggaagtataa gtgaatgata tttttctttt acatgtaaac aatgaagtta tttcaaagtt 4740
aagttttaaa caaaatacat gaagtagtgt ctgccataca tgttaatatt ctacattctt 4800
gcttccttaa attaatatgt ttgtgtgtat atatgtgcct cacacctgaa ttgaaaatta 4860
aagactggtt taaaagtggt ttaaaagtga catttaatgt ttctccatta cgtttggggt 4920
aaccagccta agtggaatct tggaaggaaa gtaagggaaa aacttgtatt tgccttcaat 4980
gaattaaacc agtgatatgt gttaacgtat gaatgaaagg attgatggtg attttataat 5040
tatatatatt gccgcagtaa ccagttaata aattgatagc taccatttaa aaa        5093



<210> 28
<211> 173
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Thr Tyr Lys Asn
 1               5                  10                  15      
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys
            20                  25                  30          
Phe Ile Glu Glu Leu Lys Lys Tyr Gly Val Thr Thr Ile Val Arg Val
        35                  40                  45              
Cys Glu Ala Thr Tyr Asp Thr Thr Leu Val Glu Lys Glu Gly Ile His
    50                  55                  60                  
Val Leu Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Ser Asn Gln Ile
65                  70                  75                  80  
Val Asp Asp Trp Leu Ser Leu Val Lys Ile Lys Phe Arg Glu Glu Pro
                85                  90                  95      
Gly Cys Cys Ile Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro
            100                 105                 110         
Val Leu Val Ala Leu Ala Leu Ile Glu Gly Gly Met Lys Tyr Glu Asp
        115                 120                 125             
Ala Val Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys
    130                 135                 140                 
Gln Leu Leu Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe
145                 150                 155                 160 
Lys Asp Ser Asn Gly His Arg Asn Asn Cys Cys Ile Gln
                165                 170             


<210> 29
<211> 2949
<212> DNA
<213> Homo sapiens

<400> 29
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc 60
gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc 120
ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt 180
ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg 240
cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg 300
accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc 360
tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt 420
atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga 480
tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg 540
ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg 600
cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg 660
ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac 720
cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc 780
tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct 840
tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc 900
ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc 960
accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc 1020
agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg 1080
gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg 1140
gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag 1200
ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt 1260
ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac 1320
ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg 1380
gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc 1440
tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca 1500
cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag 1560
gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc 1620
cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg 1680
ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag 1740
aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc 1800
tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt 1860
gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa 1920
ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac 1980
cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca 2040
gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg 2100
tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa 2160
ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa 2220
agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat 2280
attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa 2340
ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa 2400
tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt 2460
tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg 2520
cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc 2580
atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg 2640
taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt 2700
ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa 2760
tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt 2820
ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg 2880
catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa 2940
aaaaaaaaa                                                         2949

<210> 30
<211> 479
<212> PRT
<213> Homo sapiens

<400> 30
Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu
 1               5                  10                  15      
Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys
            20                  25                  30          
Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu
        35                  40                  45              
Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp
    50                  55                  60                  
Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly
65                  70                  75                  80  
Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr
                85                  90                  95      
Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser
            100                 105                 110         
Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala
        115                 120                 125             
Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala
    130                 135                 140                 
Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro
145                 150                 155                 160 
Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu
                165                 170                 175     
Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp
            180                 185                 190         
Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu
        195                 200                 205             
Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly
    210                 215                 220                 
Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser
225                 230                 235                 240 
Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp
                245                 250                 255     
Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg
            260                 265                 270         
Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu
        275                 280                 285             
Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp
    290                 295                 300                 
Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly
305                 310                 315                 320 
Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu
                325                 330                 335     
Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu
            340                 345                 350         
Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu
        355                 360                 365             
Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly
    370                 375                 380                 
Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr
385                 390                 395                 400 
Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His
                405                 410                 415     
Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly
            420                 425                 430         
Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg
        435                 440                 445             
Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala
    450                 455                 460                 
Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe
465                 470                 475                 


<210> 31
<211> 3376
<212> DNA
<213> Homo sapiens

<400> 31
ggcgaccgaa cgcggcggtc ggcagcgttc gcgcgggggc ctgcgaagcg ctgctcgggg 60
ccggcactgc ccgcggggag gacgcgccgc cgccgccacc cagcgccgcc gccgccgccg 120
cctccagccg ggccgccgcg cgtcccgggg gccggccccg cgagcgcagg agtaaacacc 180
gccggagtct tggagccgct gcagaaggga ataaagagag atgcagggat ttgtgaggtt 240
acggcgcccc agctgcaaga tgcactagcc ggctgaaccc gggatcggct gacttgttgg 300
aaccggagtg ctctgcacgg agagtggtgg atgagttgaa gttgccttcc cggggctcat 360
tttccacgct gccgagagga atccgagagg caaggcaatc acttcgtctt gccattgatt 420
gggtatcggg agcttttttt ttctcccctc tctctttctt ttcctccgtc ttgttgcatg 480
caagaaaatt acagtccgct gctcgcccgc cctgggtgcg agatattcag ccccgctctc 540
tcccgtgcat tgtgcaaccc aaagatgaaa gaccgaaggg gagaaagtta aagaaatcgc 600
ccacatgcgc tggatcagtc cacggcttgg ggaaaggcat ccagagaagg tgggagcgga 660
gagtttgaag tctttacagg cgggaagatg gcggactgga gctgaaagtg ttgattggga 720
aacttgggtg attcttgtgt ttatttacaa tcctcttgac ccaggcagga cacatgcagg 780
ccaaaaaacg ctatttcatc ctgctctcag ctggctcttg tctcgccctt ttgttttatt 840
tcggaggctt gcagtttagg gcatcgagga gccacagccg gagagaagaa cacagcggta 900
ggaatggctt gcaccacccc agtccggatc atttctggcc ccgcttcccg gacgctctgc 960
gccccttcgt tccttgggat caattggaaa acgaggattc cagcgtgcac atttcccccc 1020
ggcagaagcg agatgccaac tccagcatct acaaaggcaa gaagtgccgc atggagtcct 1080
gcttcgattt caccctttgc aagaaaaacg gcttcaaagt ctacgtatac ccacagcaaa 1140
aaggggagaa aatcgccgaa agttaccaaa acattctagc ggccatcgag ggctccaggt 1200
tctacacctc ggaccccagc caggcgtgcc tctttgtcct gagtctggat actttagaca 1260
gagaccagtt gtcacctcag tatgtgcaca atttgagatc caaagtgcag agtctccact 1320
tgtggaacaa tggtaggaat catttaattt ttaatttata ttccggcact tggcctgact 1380
acaccgagga cgtggggttt gacatcggcc aggcgatgct ggccaaagcc agcatcagta 1440
ctgaaaactt ccgacccaac tttgatgttt ctattcccct cttttctaag gatcatccca 1500
ggacaggagg ggagaggggg tttttgaagt tcaacaccat ccctcctctc aggaagtaca 1560
tgctggtatt caaggggaag aggtacctga cagggatagg atcagacacc aggaatgcct 1620
tatatcacgt ccataacggg gaggacgttg tgctcctcac cacctgcaag catggcaaag 1680
actggcaaaa gcacaaggat tctcgctgtg acagagacaa caccgagtat gagaagtatg 1740
attatcggga aatgctgcac aatgccactt tctgtctggt tcctcgtggt cgcaggcttg 1800
ggtccttcag attcctggag gctttgcagg ctgcctgcgt ccctgtgatg ctcagcaatg 1860
gatgggagtt gccattctct gaagtgatta attggaacca agctgccgtc ataggcgatg 1920
agagattgtt attacagatt ccttctacaa tcaggtctat tcatcaggat aaaatcctag 1980
cacttagaca gcagacacaa ttcttgtggg aggcttattt ttcttcagtt gagaagattg 2040
tattaactac actagagatt attcaggaca gaatattcaa gcacatatca cgtaacagtt 2100
taatatggaa caaacatcct ggaggattgt tcgtactacc acagtattca tcttatctgg 2160
gagattttcc ttactactat gctaatttag gtttaaagcc cccctccaaa ttcactgcag 2220
tcatccatgc ggtgaccccc ctggtctctc agtcccagcc agtgttgaag cttctcgtgg 2280
ctgcagccaa gtcccagtac tgtgcccaga tcatagttct atggaattgt gacaagcccc 2340
taccagccaa acaccgctgg cctgccactg ctgtgcctgt cgtcgtcatt gaaggagaga 2400
gcaaggttat gagcagccgt tttctgccct acgacaacat catcacagac gccgtgctca 2460
gccttgacga ggacacggtg ctttcaacaa cagaggtgga tttcgccttc acagtgtggc 2520
agagcttccc tgagaggatt gtggggtacc ccgcgcgcag ccacttctgg gataactcta 2580
aggagcggtg gggatacaca tcaaagtgga cgaacgacta ctccatggtg ttgacaggag 2640
ctgctattta ccacaaatat tatcactacc tatactccca ttacctgcca gccagcctga 2700
agaacatggt ggaccaattg gccaattgtg aggacattct catgaacttc ctggtgtctg 2760
ctgtgacaaa attgcctcca atcaaagtga cccagaagaa gcagtataag gagacaatga 2820
tgggacagac ttctcgggct tcccgttggg ctgaccctga ccactttgcc cagcgacaga 2880
gctgcatgaa tacgtttgcc agctggtttg gctacatgcc gctgatccac tctcagatga 2940
ggctcgaccc cgtcctcttt aaagaccagg tctctatttt gaggaagaaa taccgagaca 3000
ttgagcgact ttgaggaatc cggctgagtg ggggagggga agcaagaagg gatgggggtc 3060
aagctgctct ctcttcccag tgcagatcca ctcatcagca gagccagatt gtgccaacta 3120
tccaaaaact tagatgagca gaatgacaaa aaaaaaaagg ccaatgagaa ctcaactcct 3180
ggctcctggg actgcaccag actgctccaa actcacctca ctggcttctg tgtcccaaga 3240
ctaggttgtg tacagtttaa ttatggaaca ttaaataatt atttttgaaa tgattgctat 3300
gcaggtttaa acttttttaa tgatcaaaac tattaaaaac cagagttctt tgtttaatca 3360
aaaaaaaaaa aaaaaa                                                 3376

<210> 32
<211> 746
<212> PRT
<213> Homo sapiens

<400> 32
Met Gln Ala Lys Lys Arg Tyr Phe Ile Leu Leu Ser Ala Gly Ser Cys
 1               5                  10                  15      
Leu Ala Leu Leu Phe Tyr Phe Gly Gly Leu Gln Phe Arg Ala Ser Arg
            20                  25                  30          
Ser His Ser Arg Arg Glu Glu His Ser Gly Arg Asn Gly Leu His His
        35                  40                  45              
Pro Ser Pro Asp His Phe Trp Pro Arg Phe Pro Asp Ala Leu Arg Pro
    50                  55                  60                  
Phe Val Pro Trp Asp Gln Leu Glu Asn Glu Asp Ser Ser Val His Ile
65                  70                  75                  80  
Ser Pro Arg Gln Lys Arg Asp Ala Asn Ser Ser Ile Tyr Lys Gly Lys
                85                  90                  95      
Lys Cys Arg Met Glu Ser Cys Phe Asp Phe Thr Leu Cys Lys Lys Asn
            100                 105                 110         
Gly Phe Lys Val Tyr Val Tyr Pro Gln Gln Lys Gly Glu Lys Ile Ala
        115                 120                 125             
Glu Ser Tyr Gln Asn Ile Leu Ala Ala Ile Glu Gly Ser Arg Phe Tyr
    130                 135                 140                 
Thr Ser Asp Pro Ser Gln Ala Cys Leu Phe Val Leu Ser Leu Asp Thr
145                 150                 155                 160 
Leu Asp Arg Asp Gln Leu Ser Pro Gln Tyr Val His Asn Leu Arg Ser
                165                 170                 175     
Lys Val Gln Ser Leu His Leu Trp Asn Asn Gly Arg Asn His Leu Ile
            180                 185                 190         
Phe Asn Leu Tyr Ser Gly Thr Trp Pro Asp Tyr Thr Glu Asp Val Gly
        195                 200                 205             
Phe Asp Ile Gly Gln Ala Met Leu Ala Lys Ala Ser Ile Ser Thr Glu
    210                 215                 220                 
Asn Phe Arg Pro Asn Phe Asp Val Ser Ile Pro Leu Phe Ser Lys Asp
225                 230                 235                 240 
His Pro Arg Thr Gly Gly Glu Arg Gly Phe Leu Lys Phe Asn Thr Ile
                245                 250                 255     
Pro Pro Leu Arg Lys Tyr Met Leu Val Phe Lys Gly Lys Arg Tyr Leu
            260                 265                 270         
Thr Gly Ile Gly Ser Asp Thr Arg Asn Ala Leu Tyr His Val His Asn
        275                 280                 285             
Gly Glu Asp Val Val Leu Leu Thr Thr Cys Lys His Gly Lys Asp Trp
    290                 295                 300                 
Gln Lys His Lys Asp Ser Arg Cys Asp Arg Asp Asn Thr Glu Tyr Glu
305                 310                 315                 320 
Lys Tyr Asp Tyr Arg Glu Met Leu His Asn Ala Thr Phe Cys Leu Val
                325                 330                 335     
Pro Arg Gly Arg Arg Leu Gly Ser Phe Arg Phe Leu Glu Ala Leu Gln
            340                 345                 350         
Ala Ala Cys Val Pro Val Met Leu Ser Asn Gly Trp Glu Leu Pro Phe
        355                 360                 365             
Ser Glu Val Ile Asn Trp Asn Gln Ala Ala Val Ile Gly Asp Glu Arg
    370                 375                 380                 
Leu Leu Leu Gln Ile Pro Ser Thr Ile Arg Ser Ile His Gln Asp Lys
385                 390                 395                 400 
Ile Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Glu Ala Tyr Phe
                405                 410                 415     
Ser Ser Val Glu Lys Ile Val Leu Thr Thr Leu Glu Ile Ile Gln Asp
            420                 425                 430         
Arg Ile Phe Lys His Ile Ser Arg Asn Ser Leu Ile Trp Asn Lys His
        435                 440                 445             
Pro Gly Gly Leu Phe Val Leu Pro Gln Tyr Ser Ser Tyr Leu Gly Asp
    450                 455                 460                 
Phe Pro Tyr Tyr Tyr Ala Asn Leu Gly Leu Lys Pro Pro Ser Lys Phe
465                 470                 475                 480 
Thr Ala Val Ile His Ala Val Thr Pro Leu Val Ser Gln Ser Gln Pro
                485                 490                 495     
Val Leu Lys Leu Leu Val Ala Ala Ala Lys Ser Gln Tyr Cys Ala Gln
            500                 505                 510         
Ile Ile Val Leu Trp Asn Cys Asp Lys Pro Leu Pro Ala Lys His Arg
        515                 520                 525             
Trp Pro Ala Thr Ala Val Pro Val Val Val Ile Glu Gly Glu Ser Lys
    530                 535                 540                 
Val Met Ser Ser Arg Phe Leu Pro Tyr Asp Asn Ile Ile Thr Asp Ala
545                 550                 555                 560 
Val Leu Ser Leu Asp Glu Asp Thr Val Leu Ser Thr Thr Glu Val Asp
                565                 570                 575     
Phe Ala Phe Thr Val Trp Gln Ser Phe Pro Glu Arg Ile Val Gly Tyr
            580                 585                 590         
Pro Ala Arg Ser His Phe Trp Asp Asn Ser Lys Glu Arg Trp Gly Tyr
        595                 600                 605             
Thr Ser Lys Trp Thr Asn Asp Tyr Ser Met Val Leu Thr Gly Ala Ala
    610                 615                 620                 
Ile Tyr His Lys Tyr Tyr His Tyr Leu Tyr Ser His Tyr Leu Pro Ala
625                 630                 635                 640 
Ser Leu Lys Asn Met Val Asp Gln Leu Ala Asn Cys Glu Asp Ile Leu
                645                 650                 655     
Met Asn Phe Leu Val Ser Ala Val Thr Lys Leu Pro Pro Ile Lys Val
            660                 665                 670         
Thr Gln Lys Lys Gln Tyr Lys Glu Thr Met Met Gly Gln Thr Ser Arg
        675                 680                 685             
Ala Ser Arg Trp Ala Asp Pro Asp His Phe Ala Gln Arg Gln Ser Cys
    690                 695                 700                 
Met Asn Thr Phe Ala Ser Trp Phe Gly Tyr Met Pro Leu Ile His Ser
705                 710                 715                 720 
Gln Met Arg Leu Asp Pro Val Leu Phe Lys Asp Gln Val Ser Ile Leu
                725                 730                 735     
Arg Lys Lys Tyr Arg Asp Ile Glu Arg Leu
            740                 745     


<210> 33
<211> 4827
<212> DNA
<213> Homo sapiens

<400> 33
gaagggcaac acggggacct tgaagcgggg tcgcggcggc gccccagccc gggccaggga 60
gtcccggcag cggcacctcc cagaaagggc ggagccgacg acgccttctt ccttcctgac 120
cggcgcgcgc agcctgctgc cgcggtcagc gcctgctcct gctcctccgc tcctcctgcg 180
cggggtgctg aaacagcccg gggaagtaga gccgcctccg gggagcccaa ccagccgaac 240
gccgccggcg tcagcagcct tgcgcggcca cagcatgacc gctcgcggcc tggcccttgg 300
cctcctcctg ctgctactgt gtccagcgca ggtgttttca cagtcctgtg tttggtatgg 360
agagtgtgga attgcatatg gggacaagag gtacaattgc gaatattctg gcccaccaaa 420
accattgcca aaggatggat atgacttagt gcaggaactc tgtccaggat tcttctttgg 480
caatgtcagt ctctgttgtg atgttcggca gcttcagaca ctaaaagaca acctgcagct 540
gcctctacag tttctgtcca gatgtccatc ctgtttttat aacctactga acctgttttg 600
tgagctgaca tgtagccctc gacagagtca gtttttgaat gttacagcta ctgaagatta 660
tgttgatcct gttacaaacc agacgaaaac aaatgtgaaa gagttacaat actacgtcgg 720
acagagtttt gccaatgcaa tgtacaatgc ctgccgggat gtggaggccc cctcaagtaa 780
tgacaaggcc ctgggactcc tgtgtgggaa ggacgctgac gcctgtaatg ccaccaactg 840
gattgaatac atgttcaata aggacaatgg acaggcacct tttaccatca ctcctgtgtt 900
ttcagatttt ccagtccatg ggatggagcc catgaacaat gccaccaaag gctgtgacga 960
gtctgtggat gaggtcacag caccatgtag ctgccaagac tgctctattg tctgtggccc 1020
caagccccag cccccacctc ctcctgctcc ctggacgatc cttggcttgg acgccatgta 1080
tgtcatcatg tggatcacct acatggcgtt tttgcttgtg ttttttggag cattttttgc 1140
agtgtggtgc tacagaaaac ggtattttgt ctccgagtac actcccatcg atagcaatat 1200
agctttttct gttaatgcaa gtgacaaagg agaggcgtcc tgctgtgacc ctgtcagcgc 1260
agcatttgag ggctgcttga ggcggctgtt cacacgctgg gggtctttct gcgtccgaaa 1320
ccctggctgt gtcattttct tctcgctggt cttcattact gcgtgttcgt caggcctggt 1380
gtttgtccgg gtcacaacca atccagttga cctctggtca gcccccagca gccaggctcg 1440
cctggaaaaa gagtactttg accagcactt tgggcctttc ttccggacgg agcagctcat 1500
catccgggcc cctctcactg acaaacacat ttaccagcca tacccttcgg gagctgatgt 1560
accctttgga cctccgcttg acatacagat actgcaccag gttcttgact tacaaatagc 1620
catcgaaaac attactgcct cttatgacaa tgagactgtg acacttcaag acatctgctt 1680
ggcccctctt tcaccgtata acacgaactg caccattttg agtgtgttaa attacttcca 1740
gaacagccat tccgtgctgg accacaagaa aggggacgac ttctttgtgt atgccgatta 1800
ccacacgcac tttctgtact gcgtacgggc tcctgcctct ctgaatgata caagtttgct 1860
ccatgaccct tgtctgggta cgtttggtgg accagtgttc ccgtggcttg tgttgggagg 1920
ctatgatgat caaaactaca ataacgccac tgcccttgtg attaccttcc ctgtcaataa 1980
ttactataat gatacagaga agctccagag ggcccaggcc tgggaaaaag agtttattaa 2040
ttttgtgaaa aactacaaga atcccaatct gaccatttcc ttcactgctg aacgaagtat 2100
tgaagatgaa ctaaatcgtg aaagtgacag tgatgtcttc accgttgtaa ttagctatgc 2160
catcatgttt ctatatattt ccctagcctt ggggcacatg aaaagctgtc gcaggcttct 2220
ggtggattcg aaggtctcac taggcatcgc gggcatcttg atcgtgctga gctcggtggc 2280
ttgctccttg ggtgtcttca gctacattgg gttgcccttg accctcattg tgattgaagt 2340
catcccgttc ctggtgctgg ctgttggagt ggacaacatc ttcattctgg tgcaggccta 2400
ccagagagat gaacgtcttc aaggggaaac cctggatcag cagctgggca gggtcctagg 2460
agaagtggct cccagtatgt tcctgtcatc cttttctgag actgtagcat ttttcttagg 2520
agcattgtcc gtgatgccag ccgtgcacac cttctctctc tttgcgggat tggcagtctt 2580
cattgacttt cttctgcaga ttacctgttt cgtgagtctc ttggggttag acattaaacg 2640
tcaagagaaa aatcggctag acatcttttg ctgtgtcaga ggtgctgaag atggaacaag 2700
cgtccaggcc tcagagagct gtttgtttcg cttcttcaaa aactcctatt ctccacttct 2760
gctaaaggac tggatgagac caattgtgat agcaatattt gtgggtgttc tgtcattcag 2820
catcgcagtc ctgaacaaag tagatattgg attggatcag tctctttcga tgccagatga 2880
ctcctacatg gtggattatt tcaaatccat cagtcagtac ctgcatgcgg gtccgcctgt 2940
gtactttgtc ctggaggaag ggcacgacta cacttcttcc aaggggcaga acatggtgtg 3000
cggcggcatg ggctgcaaca atgattccct ggtgcagcag atatttaacg cggcgcagct 3060
ggacaactat acccgaatag gcttcgcccc ctcgtcctgg atcgacgatt atttcgactg 3120
ggtgaagcca cagtcgtctt gctgtcgagt ggacaatatc actgaccagt tctgcaatgc 3180
ttcagtggtt gaccctgcct gcgttcgctg caggcctctg actccggaag gcaaacagag 3240
gcctcagggg ggagacttca tgagattcct gcccatgttc ctttcggata accctaaccc 3300
caagtgtggc aaagggggac atgctgccta tagttctgca gttaacatcc tccttggcca 3360
tggcaccagg gtcggagcca cgtacttcat gacctaccac accgtgctgc agacctctgc 3420
tgactttatt gacgctctga agaaagcccg acttatagcc agtaatgtca ccgaaaccat 3480
gggcattaac ggcagtgcct accgagtatt tccttacagt gtgttttatg tcttctacga 3540
acagtacctg accatcattg acgacactat cttcaacctc ggtgtgtccc tgggcgcgat 3600
atttctggtg accatggtcc tcctgggctg tgagctctgg tctgcagtca tcatgtgtgc 3660
caccatcgcc atggtcttgg tcaacatgtt tggagttatg tggctctggg gcatcagtct 3720
gaacgctgta tccttggtca acctggtgat gagctgtggc atctccgtgg agttctgcag 3780
ccacataacc agagcgttca cggtgagcat gaaaggcagc cgcgtggagc gcgcggaaga 3840
ggcacttgcc cacatgggca gctccgtgtt cagtggaatc acacttacaa aatttggagg 3900
gattgtggtg ttggcttttg ccaaatctca aattttccag atattctact tcaggatgta 3960
tttggccatg gtcttactgg gagccactca cggattaata tttctccctg tcttactcag 4020
ttacataggg ccatcagtaa ataaagccaa aagttgtgcc actgaagagc gatacaaagg 4080
aacagagcgc gaacggcttc taaatttcta gccctctcgc agggcatcct gactgaactg 4140
tgtctaaggg tcggtcggtt taccactgga cgggtgctgc atcggcaagg ccaagttgaa 4200
caccggatgg tgccaaccat cggttgtttg gcagcagctt tgaacgtagc gcctgtgaac 4260
tcaggaatgc acagttgact tgggaagcag tattactaga tctggaggca accacaggac 4320
actaaacttc tcccagcctc ttcaggaaag aaacctcatt ctttggcaag caggaggtga 4380
cactagatgg ctgtgaatgt gatccgctca ctgacactct gtaaaggcca atcaatgcac 4440
tgtctgtctc tccttttagg agtaagccat cccacaagtt ctataccata tttttagtga 4500
cagttgaggt tgtagataca ctttataaca ttttatagtt taaagagctt tattaatgca 4560
ataaattaac tttgtacaca tttttatata aaaaaacagc aagtgatttc agaatgttgt 4620
aggcctcatt agagcttggt ctccaaaaat ctgtttgaaa aaagcaacat gttcttcaca 4680
gtgttcccct agaaaggaag agatttaatt gccagttaga tgtggcatga aatgagggac 4740
aaagaaagca tctcgtaggt gtgtctactg ggttttaact tatttttctt taataaaata 4800
cattgttttc ctaaaaaaaa aaaaaaa                                     4827

<210> 34
<211> 1278
<212> PRT
<213> Homo sapiens

<400> 34
Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys
 1               5                  10                  15      
Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly
            20                  25                  30          
Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro
        35                  40                  45              
Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro
    50                  55                  60                  
Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu
65                  70                  75                  80  
Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg
                85                  90                  95      
Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr
            100                 105                 110         
Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp
        115                 120                 125             
Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu
    130                 135                 140                 
Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys
145                 150                 155                 160 
Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu
                165                 170                 175     
Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr
            180                 185                 190         
Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val
        195                 200                 205             
Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr
    210                 215                 220                 
Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys
225                 230                 235                 240 
Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro
                245                 250                 255     
Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met
            260                 265                 270         
Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe
        275                 280                 285             
Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro
    290                 295                 300                 
Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu
305                 310                 315                 320 
Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg
                325                 330                 335     
Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys
            340                 345                 350         
Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu
        355                 360                 365             
Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro
    370                 375                 380                 
Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly
385                 390                 395                 400 
Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp
                405                 410                 415     
Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly
            420                 425                 430         
Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile
        435                 440                 445             
Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu
    450                 455                 460                 
Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr
465                 470                 475                 480 
Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp
                485                 490                 495     
His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His
            500                 505                 510         
Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu
        515                 520                 525             
Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp
    530                 535                 540                 
Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala
545                 550                 555                 560 
Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys
                565                 570                 575     
Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys
            580                 585                 590         
Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser
        595                 600                 605             
Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val
    610                 615                 620                 
Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly
625                 630                 635                 640 
His Met Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu
                645                 650                 655     
Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu
            660                 665                 670         
Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu
        675                 680                 685             
Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile
    690                 695                 700                 
Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu
705                 710                 715                 720 
Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe
                725                 730                 735     
Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser
            740                 745                 750         
Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val
        755                 760                 765             
Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly
    770                 775                 780                 
Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys
785                 790                 795                 800 
Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys
                805                 810                 815     
Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp
            820                 825                 830         
Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe
        835                 840                 845             
Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu
    850                 855                 860                 
Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser
865                 870                 875                 880 
Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly
                885                 890                 895     
His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met
            900                 905                 910         
Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln
        915                 920                 925             
Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp
    930                 935                 940                 
Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp
945                 950                 955                 960 
Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys
                965                 970                 975     
Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly
            980                 985                 990         
Gly Asp Phe Met Arg Phe Leu Pro Met Phe Leu Ser Asp Asn Pro Asn
        995                 1000                1005            
Pro Lys Cys Gly Lys Gly Gly His Ala Ala Tyr Ser Ser Ala Val Asn
    1010                1015                1020                
Ile Leu Leu Gly His Gly Thr Arg Val Gly Ala Thr Tyr Phe Met Thr
1025                1030                1035               1040 
Tyr His Thr Val Leu Gln Thr Ser Ala Asp Phe Ile Asp Ala Leu Lys
                1045                1050                1055    
Lys Ala Arg Leu Ile Ala Ser Asn Val Thr Glu Thr Met Gly Ile Asn
            1060                1065                1070        
Gly Ser Ala Tyr Arg Val Phe Pro Tyr Ser Val Phe Tyr Val Phe Tyr
        1075                1080                1085            
Glu Gln Tyr Leu Thr Ile Ile Asp Asp Thr Ile Phe Asn Leu Gly Val
    1090                1095                1100                
Ser Leu Gly Ala Ile Phe Leu Val Thr Met Val Leu Leu Gly Cys Glu
1105                1110                1115               1120 
Leu Trp Ser Ala Val Ile Met Cys Ala Thr Ile Ala Met Val Leu Val
                1125                1130                1135    
Asn Met Phe Gly Val Met Trp Leu Trp Gly Ile Ser Leu Asn Ala Val
            1140                1145                1150        
Ser Leu Val Asn Leu Val Met Ser Cys Gly Ile Ser Val Glu Phe Cys
        1155                1160                1165            
Ser His Ile Thr Arg Ala Phe Thr Val Ser Met Lys Gly Ser Arg Val
    1170                1175                1180                
Glu Arg Ala Glu Glu Ala Leu Ala His Met Gly Ser Ser Val Phe Ser
1185                1190                1195               1200 
Gly Ile Thr Leu Thr Lys Phe Gly Gly Ile Val Val Leu Ala Phe Ala
                1205                1210                1215    
Lys Ser Gln Ile Phe Gln Ile Phe Tyr Phe Arg Met Tyr Leu Ala Met
            1220                1225                1230        
Val Leu Leu Gly Ala Thr His Gly Leu Ile Phe Leu Pro Val Leu Leu
        1235                1240                1245            
Ser Tyr Ile Gly Pro Ser Val Asn Lys Ala Lys Ser Cys Ala Thr Glu
    1250                1255                1260                
Glu Arg Tyr Lys Gly Thr Glu Arg Glu Arg Leu Leu Asn Phe
1265                1270                1275            


<210> 35
<211> 6139
<212> DNA
<213> Homo sapiens

<400> 35
gtcttcctcc cccagggttg tggccacgcg cagcggcggc ggttgttccg cttcccctcc 60
ggcccgggcc gtcgccattg ccgaaggctc cctcccctcc cctccctggc gtgcgcagga 120
ctccgccgcc gctgggccta gcggtagcag cggctgctcc agcgcggcgt ctcttcccgc 180
cccgcttccc cttccctccc ctcccctccc cgcaccgcgc gctagcccgg ggcggctccg 240
cagcccgccg ggagctctga ccgaggcgcc tcgctggggc ggggaccttg ccttgcccgg 300
ggccatttca taattctgaa tcatgtctga taacggagaa ctggaagata agcctccagc 360
acctcctgtg cgaatgagca gcaccatctt tagcactgga ggcaaagacc ctttgtcagc 420
caatcacagt ttgaaacctt tgccctctgt tccagaagag aaaaagccca ggcataaaat 480
catctccata ttctcaggca cagagaaagg aagtaaaaag aaagaaaagg aacggccaga 540
aatttctcct ccatctgatt ttgagcacac catccatgtt ggctttgatg ctgttactgg 600
agaattcact ggcatgccag aacagtgggc tcgattacta cagacctcca atatcaccaa 660
actagagcaa aagaagaatc ctcaggctgt gctggatgtc ctaaagttct acgactccaa 720
cacagtgaag cagaaatatc tgagctttac tcctcctgag aaagatggct ttccttctgg 780
aacaccagca ctgaatgcca agggaacaga agcacccgca gtagtgacag aggaggagga 840
tgatgatgaa gagactgctc ctcccgttat tgccccgcga ccggatcata cgaaatcaat 900
ttacacacgg tctgtaattg accctgttcc tgcaccagtt ggtgattcac atgttgatgg 960
tgctgccaag tctttagaca aacagaaaaa gaagactaag atgacagatg aagagattat 1020
ggagaaatta agaactatcg tgagcatagg tgaccctaag aaaaaatata caagatatga 1080
aaaaattgga caaggggctt ctggtacagt tttcactgct actgacgttg cactgggaca 1140
ggaggttgct atcaaacaaa ttaatttaca gaaacagcca aagaaggaac tgatcattaa 1200
cgagattctg gtgatgaaag aattgaaaaa tcccaacatc gttaactttt tggacagtta 1260
cctggtagga gatgaattgt ttgtggtcat ggaatacctt gctggggggt cactcactga 1320
tgtggtaaca gaaacgtgca tggatgaagc acagattgct gctgtatgca gagagtgttt 1380
acaggcattg gagtttttac atgctaatca agtgatccac agagacatca aaagtgacaa 1440
tgtacttttg ggaatggaag gatctgttaa gctcactgac tttggtttct gtgcccagat 1500
cacccctgag cagagcaaac gcagtaccat ggtcggaacg ccatactgga tggcaccaga 1560
ggtggttaca cggaaagctt atggccctaa agtcgacata tggtctctgg gtatcatggc 1620
tattgagatg gtagaaggag agcctccata cctcaatgaa aatcccttga gggccttgta 1680
cctaatagca actaatggaa ccccagaact tcagaatcca gagaaacttt ccccaatatt 1740
tcgggatttc ttaaatcgat gtttggaaat ggatgtggaa aaaaggggtt cagccaaaga 1800
attattacag catcctttcc tgaaactggc caaaccgtta tctagcttga caccactgat 1860
catggcagct aaagaagcaa tgaagagtaa ccgttaacat cactgctgtg gcctcatact 1920
cttttttcca ttttctacaa gaagcctttt agtatatgaa aattattact ctttttgggg 1980
tttaaagaaa tggtctgcat aacctgaatg aaagaagcaa atgactattc tctgaagaca 2040
accaagagaa aattgcaaaa agacaagtat gacttttata tgaacccctt ctttagggtc 2100
cagaaggaat tgtggactga atcactagcc ttaggtcttt cagcaaacag cctatcaggg 2160
ccatttatca tgtgtgagat ttgcatttta ctttgctgac tttgttgtaa tagatcccat 2220
tcattgtccc ctttggggta tttccaatac ttgaatggca gattggagtt tttcagagta 2280
tgtgtttcat ctgctagtct ttctctcctt catagctttt cttttcctgg acttgctcct 2340
tttgagttgc ttttgcgttt ctcatgccta ggcaagtgta atagaaatta tgtagctcct 2400
tatgttggca aaggagctct atatagtttc actttgtata aaagttagga ccagctgttg 2460
ttacatgtaa tattttagtt cagaacttga cctgaaggaa gggaagaaaa gtatgtgatt 2520
tttacctttt ttaacaaatg tgaaaaagtc agttttagaa atttcgtggt agtaagttcg 2580
gcatttgtta catgtataga gagaagacta ataatctcta tttataacta aatcattgag 2640
atagaaaaag attcccattg actgtagact tcttcccatt ttgtcttccc ttctgcctgt 2700
ttccccttca ggcttggctc taggaaccaa agtgatttgt tgttgttcca acctgggctt 2760
tgtgactttg gttagtgcca ctaccttctt ccctcctttc ccccttcaat ttggaaataa 2820
atttctgtat atgttgcaat tttaggttta ggtttgttct ttttcttttt cattaatcct 2880
ctctcacctc acagataccc cctcccatgg caaataatat aataaccagt gaattttcag 2940
gaatttaaaa attagctttt ttccacttaa aggagaaaaa tatttgggac tagcagcaga 3000
ggcagtaaga gatgtgaacc ttggtgagct ctgatacagt gagaagagat tatactcatg 3060
aaagagaatg ttagtgttac agagaagcag ccgatagcaa atcgactgta gagacttggc 3120
ggcggtggca ttgccccagg tcgtcagcag tgtggtatta tctatgagaa cttgagcgac 3180
agagtatttc ttgatgaatt tatagatcat ttgagatgtt gagttacttt agtttagttt 3240
tgttttgttt tttcaaataa gtagagacta ttgtaaaaaa cgagaaagga aaatgaaatg 3300
tgcgtgttga tagcaataat ttgtttcttt taaagattct aaaaggtctg agacctgtag 3360
cattaattat ttgagtgccc tcccttctcc cctcccctcc cttttctctt ctcttttttc 3420
ctctcctctt cttctccttt attcattgtt ttgcttttgg agtgggtgtt gttcaagtat 3480
ctgtggtttg gttctggcat tttgttccca ccatcccctt cccccattaa cttcccccct 3540
gcttgccatc ctgcagtagt ataaatcatg aataaaaaat aattttgctg ttgtagtata 3600
cattggagaa actggcaggt tttatttcca ttattttatt tccactatat ctatgataag 3660
atgcaattat aaggagagaa gtgactgttt tttattgata aggcaagatt ttcagaaaaa 3720
tgagtaaaat aattaatgaa acatatttag agcacttaat ggtctctgtt ttcaatataa 3780
ttcttgattt catttttctc tggaatatat tggccttcta cagctattac tgaattatag 3840
aaactggttt atttctggca gaaagctgca gtgccacctg agttccaaat tttaccattc 3900
tttgtaaaca gttggatgga ttatgataaa gaagatgcta ccaatgaaat agaaaaccaa 3960
cgagatgaga agactgtgat cctcatgtac tcagaggcac ttccctccta agtcaaagac 4020
catcctcact gactatgtgc caacgcctcg tttcaggctt gtgactcaac aaagggcttt 4080
tccattgata gaagcagttt gggatttgta gttgcgactt cttcgatagt tacctgcacg 4140
tccattgctg gcaactgact tgtcattaaa acctggctct ttggttaagg gagctacgct 4200
gtggtttatt cttaagttac gtggataaac taacctctaa cagaaatata ctttggttaa 4260
ttttgaaatg tgtcattttt aaacaatctt aaaagtaata cagaattgtg atttattaat 4320
tttaaaacat tcagaacttg ttgaaagaaa aattatatct gaatcaagat tcatgttttt 4380
tatttttatt ttttttgata cagagtctca ctctgtcact caggctggag tgcagtgaca 4440
tgatctcagc tcactgcaac ctccgcttcc tgggttcaag caattctcat gcctcagcct 4500
cctgagtagc tgagaccaca ggcacccgcc accacaccca gctatttttt tgtattttta 4560
gtagagacag agtctcacca cattgcccag gctggtctcc aactcctgag ctcaggcagt 4620
ctgcccacct tggcctccca aagtgctgca gttacaggcg tgagccactg cacctggcct 4680
catgtttttt aaataattgc cttttatatt tacccttttt gtcatcactt tagaatgaaa 4740
attcccattt aaatctgaaa gttaccttaa tagtcctctt gtgttattag gacagtatta 4800
ttatagtact tatttatttt attttagatt taaagttatc ttctcttttt cttttttctt 4860
ctgctgcttt tagggacaat taaaactggg aaactatgaa acatggaaca ttttatccta 4920
cctgaaagta aacgagtaat tgtgaagcat aagacactga ggctaataca actctgtctt 4980
catgtgttga ctgcctggca catagtattc attctcttcc ctttaacata gaagtgtcca 5040
gctgcgtaca gtctagtaac cagcaactgt aaacgaacct gtgcctctaa caagcgattc 5100
taaaccacct atgagtattt cttttagggc tcacttaaat acatgtttgt atatactgta 5160
ttctagccag aataatttta gatctgatca ggtagtagct aaaattagaa aaaaacaaaa 5220
tagatgctta aagaatttgc atccattttt gagtctaaat cttttaaaat atactgagat 5280
ccacatctag tgaaatgtca gtgtcaaaat attatagatt atagctaaaa tccagattaa 5340
tactcatttg gggtttttta tagtggaact tcatagtaat acaaaaagca gattgtcttc 5400
ctgtctccgc tgctcccaca gtaggtattg aaactggtaa aatcagtttt ttgatagtgt 5460
gtgtatataa gaaaaaatag atacacacat tcttttttct cagtcaacac attgattgaa 5520
cactctggca aagatgctgt ggtggatgag gttggagttc gaaagaagaa gcaagcgctg 5580
gcctggcctt gaaagaaccg aagtctttcc cattcacttc tctagaaagc tgccaagaca 5640
gaggcagaaa gaaatggatg atagttctgt caagcacact tctgttctct tagaacttag 5700
aagtgtttct aagagaacag aagtaataag agaaacagtt acgtgtggaa ttcaacatct 5760
ttggttggaa cgcattggct ttttttttct tgttttgata gaaatggaat taagcaaaag 5820
tagtttttgt cttttctgtt gtcttcaaat tttatgcctt ttatttttaa tttaatcccg 5880
ttcaattatt taattgttat acattgacat taactgctgt attttgactt tgttcaataa 5940
ttttgttctt tcagggctag aaataaactt tttaaaaaaa gtgtgcattt ttccctttcc 6000
taaactttta ttctttcttt tgatcagcgt aaaagaatat tttaatgtct tttgatagca 6060
taaaagaata tttaaatgtc ttaataggtt ttcaaagaac atttagtatt tttagtgata 6120
aatgttttaa accttttaa                                              6139



<210> 36
<211> 524
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Asp Asn Gly Glu Leu Glu Asp Lys Pro Pro Ala Pro Pro Val
 1               5                  10                  15      
Arg Met Ser Ser Thr Ile Phe Ser Thr Gly Gly Lys Asp Pro Leu Ser
            20                  25                  30          
Ala Asn His Ser Leu Lys Pro Leu Pro Ser Val Pro Glu Glu Lys Lys
        35                  40                  45              
Pro Arg His Lys Ile Ile Ser Ile Phe Ser Gly Thr Glu Lys Gly Ser
    50                  55                  60                  
Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Pro Pro Ser Asp Phe
65                  70                  75                  80  
Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr
                85                  90                  95      
Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr
            100                 105                 110         
Lys Leu Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys
        115                 120                 125             
Phe Tyr Asp Ser Asn Thr Val Lys Gln Lys Tyr Leu Ser Phe Thr Pro
    130                 135                 140                 
Pro Glu Lys Asp Gly Phe Pro Ser Gly Thr Pro Ala Leu Asn Ala Lys
145                 150                 155                 160 
Gly Thr Glu Ala Pro Ala Val Val Thr Glu Glu Glu Asp Asp Asp Glu
                165                 170                 175     
Glu Thr Ala Pro Pro Val Ile Ala Pro Arg Pro Asp His Thr Lys Ser
            180                 185                 190         
Ile Tyr Thr Arg Ser Val Ile Asp Pro Val Pro Ala Pro Val Gly Asp
        195                 200                 205             
Ser His Val Asp Gly Ala Ala Lys Ser Leu Asp Lys Gln Lys Lys Lys
    210                 215                 220                 
Thr Lys Met Thr Asp Glu Glu Ile Met Glu Lys Leu Arg Thr Ile Val
225                 230                 235                 240 
Ser Ile Gly Asp Pro Lys Lys Lys Tyr Thr Arg Tyr Glu Lys Ile Gly
                245                 250                 255     
Gln Gly Ala Ser Gly Thr Val Phe Thr Ala Thr Asp Val Ala Leu Gly
            260                 265                 270         
Gln Glu Val Ala Ile Lys Gln Ile Asn Leu Gln Lys Gln Pro Lys Lys
        275                 280                 285             
Glu Leu Ile Ile Asn Glu Ile Leu Val Met Lys Glu Leu Lys Asn Pro
    290                 295                 300                 
Asn Ile Val Asn Phe Leu Asp Ser Tyr Leu Val Gly Asp Glu Leu Phe
305                 310                 315                 320 
Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val Val Thr
                325                 330                 335     
Glu Thr Cys Met Asp Glu Ala Gln Ile Ala Ala Val Cys Arg Glu Cys
            340                 345                 350         
Leu Gln Ala Leu Glu Phe Leu His Ala Asn Gln Val Ile His Arg Asp
        355                 360                 365             
Ile Lys Ser Asp Asn Val Leu Leu Gly Met Glu Gly Ser Val Lys Leu
    370                 375                 380                 
Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser Lys Arg
385                 390                 395                 400 
Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Val Thr
                405                 410                 415     
Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly Ile Met
            420                 425                 430         
Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu Asn Pro
        435                 440                 445             
Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu Leu Gln
    450                 455                 460                 
Asn Pro Glu Lys Leu Ser Pro Ile Phe Arg Asp Phe Leu Asn Arg Cys
465                 470                 475                 480 
Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys Glu Leu Leu Gln
                485                 490                 495     
His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr Pro Leu
            500                 505                 510         
Ile Met Ala Ala Lys Glu Ala Met Lys Ser Asn Arg
        515                 520                 


<210> 37
<211> 10573
<212> DNA
<213> Homo sapiens

<400> 37
gcggggggag ggcgagccca agcgcggggg agggagtgta aatagagcga aggctgctct 60
gtgtcagccc cgtcaccgcc gggcggcccg cgcggagtct gagggagatg gaagttgagc 120
aagagcagcg gcgcagaaag gtggaggccg ggaggacgaa gcttgctcac ttccgacaga 180
gaaaaacaaa aggtgacagt tcgcattcgg agaaaaagac ggcgaagagg aagggctcgg 240
ctgtcgatgc gtctgtccag gaggagagtc cggtaaccaa ggaggacagc gcactctgtg 300
gaggagggga catttgcaaa agcacatcat gtgacgacac ccctgatggg gcaggagggg 360
cctttgcagc tcagccggag gactgtgatg gagagaagag agaggacttg gaacagctgc 420
agcagaagca agtcaatgac catcctccag agcagtgtgg gatgttcaca gtcagtgacc 480
acccaccaga acagcatggg atgttcacag tcggtgacca cccaccagaa cagcgtggga 540
tgttcacagt cagtgaccac ccaccagaac agcatgggat gttcacagtc agtgaccacc 600
caccagaaca gcgtgggatg ttcacaatca gtgaccacca accggaacag cgtgggatgt 660
tcacagtcag tgaccacaca ccagaacagc gtgggatctt cacaatcagt gaccacccag 720
cagaacagcg tgggatgttc acaaaggagt gtgaacaaga atgtgaactt gccattactg 780
acctggagag cggccgtgaa gatgaggctg gcctgcatca gagtcaggcc gtgcatggcc 840
ttgagctgga ggcgctgcgc ctgagtctga gcaacatgca cacggcgcag ctggagctga 900
cacaggccaa cctccagaag gagaaggaga cggcattgac ggagctgcgg gagatgctca 960
acagccggcg tgcccaggag ctggccctgc tacagagcag gcagcagcac gagctggagc 1020
tcctcaggga gcagcacgca cgggagaagg aggaggtggt gctcaggtgt ggacaggaag 1080
cagctgagct gaaggagaag ttacaatcag aaatggagaa aaacgcccag atagtaaaga 1140
ccctgaagga agattgggaa tctgaaaaag atttatgttt agaaaatcta cgcaaagaac 1200
tgtctgcaaa gcatcaatca gaaatggagg atttacaaaa ccagtttcag aaagaattgg 1260
cagaacagag agctgagttg gagaagattt ttcaagacaa aaaccaggct gaacgggccc 1320
ttaggaacct ggagagtcat catcaagcag ccattgagaa gttacgtgaa gacctgcagt 1380
ccgagcacgg ccggtgttta gaagacttgg agttcaagtt caaagagagc gagaaagaaa 1440
aacagctgga gttagagaat cttcaagcat catatgaaga cctgaaggca caatcacaag 1500
aagagatcag gcgcttgtgg tcccagcttg attctgccag gaccagtaga caggaattga 1560
gtgagctaca tgagcaactc ctggcgcgca cctctcgtgt ggaagattta gaacagctga 1620
agcagcgaga aaaaacccag catgagtccg aactggagca actgaggatt tattttgaaa 1680
agaagttaag ggatgctgag aaaacttacc aagaagacct aaccctgtta cagcagaggc 1740
tgcagggggc gagggaagat gctcttctgg actctgtgga agttgggttg tcctgtgtgg 1800
gtttagaaga gaaacctgag aaaggaagaa aagatcacgt tgatgaactc gagcctgagc 1860
gacataagga gagcctgcca cgcttccagg cggagttaga agaaagccac aggcaccagc 1920
tggaagcgct ggagtctccc ctctgcatcc agcacgaggg gcatgtctca gacagatgct 1980
gcgtagagac ttcagcattg ggacacgagt ggcgtctgga accctctgaa gggcacagcc 2040
aagagcttcc ctgggtgcat ctccagggtg tgcaggacgg ggacttggag gccgacacag 2100
agcgggcagc cagagtcttg ggtctggaaa ctgagcacaa ggtgcaactt tcgcttcttc 2160
agactgagct caaagaagaa attgaactcc taaaaataga aaatagaaat ttgtatggga 2220
agttgcagca tgaaactcgt ctgaaggacg atttggagaa ggtaaaacac aatctaattg 2280
aagaccacca gaaggaacta aataatgcta agcaaaagac tgagctgatg aaacaggaat 2340
tccaaagaaa agaaacggac tggaaagtta tgaaggagga gctacagcgg gaagctgagg 2400
agaagttaac attgatgcta cttgaactga gagaaaaggc tgaatccgag aaacagacca 2460
tcataaacaa gtttgagctt cgagaagctg aaatgaggca gcttcaggac caacaggcag 2520
cccagatcct ggatctggag aggtccttga cggagcagca gggccgcctg cagcagctgg 2580
aacaggacct cacttcagac gacgccctgc attgcagcca gtgtgggcgg gagccgccca 2640
cagcccagga cggggagctt gctgcgctcc acgtgaagga agactgcgcc ctgcagctga 2700
tgctggcccg gagcaggttt ttagaggaac gtaaagagat caccgagaaa ttcagtgcgg 2760
aacaagatgc cttcctgcag gaggcccagg agcagcatgc ccgtgagctg cagctcctcc 2820
aggagagaca ccagcagcag ctcctgtcag tgacggcgga gctcgaggcc agacaccagg 2880
ccgcgttggg cgagctgaca gcctccttag agagcaagca gggggctctg ctggctgcac 2940
gtgtggccga actgcagaca aaacacgctg ccgacctcgg cgctctggag accagacatc 3000
tgtccagcct tgattctttg gaatcctgtt acctctctga atttcagacc atccgtgagg 3060
agcacaggca ggccctagag ctcttacgag cagactttga ggaacaactg tggaaaaagg 3120
actctcttca ccaaacgatt ttgactcaag agttggagaa actgaagcgg aaacacgaag 3180
gggagctaca gtctgtgcgg gaccacctgc gaaccgaagt gagcacagag ctcgccggaa 3240
ccgtggctca cgagctgcag ggagtgcacc agggtgaatt tggaagtgaa aagaaaactg 3300
ctttgcatga aaaagaggag acacttcggc ttcagagtgc acaggcacag ccttttcacc 3360
aagaggagaa agagtctttg tctctgcagc ttcaaaagaa gaatcaccaa gtccagcagc 3420
tgaaagacca ggttttatcc ttaagtcacg agatagaaga gtgccgctcc gagttggagg 3480
tgctgcagca gaggcgggag cgggagaacc gggaaggcgc aaacctcctc tccatgctca 3540
aggccgacgt caacctgtcc cacagcgaaa gaggggccct ccaggacgcc ctgcgcaggc 3600
tgctgggttt gtttggagag acgctgaggg cagccgtcac cctgaggagc cggatcgggg 3660
agcgcgtggg gctctgcctg gatgacgcgg gcgcaggcct ggccctgtcg acagctccgg 3720
cgctggagga gacatggtct gatgtggccc tcccggagtt ggacagaact ttgtctgaat 3780
gtgcagagat gtcttccgtg gctgaaatta gcagccacat gcgtgaaagc tttctcatga 3840
gcccagaaag tgtgcgggag tgtgagcagc ccatccggag ggtcttccag agcctcagcc 3900
tggccgtgga cggcctcatg gagatggccc tggactccag caggcagctg gaagaagcac 3960
gccaaattca ttctcgtttt gaaaaagaat ttagttttaa gaatgaggag acagcacagg 4020
ttgtcaggaa gcaccaggag ctgctggagt gtttgaagga ggagagcgca gcaaaggcag 4080
agctggcgct ggagctgcac aagactcagg gtacccttga gggattcaag gtggagacag 4140
cagatctgaa ggaggtgctg gccgggaagg aggattccga gcaccgtctg gtgctggagc 4200
tggagagcct gagacggcag ctgcagcagg cggcccagga gcaggcggcg ctgagggagg 4260
agtgcacccg tctgtggagt cggggggagg ccacagccac ggacgccgag gccagagaag 4320
ctgctctccg gaaggaagtg gaggatctga ccaaagaaca gtcggagacc aggaagcagg 4380
ctgagaagga ccgctcagcc ctgctctccc agatgaagat tttggagtct gagttagaag 4440
aacagctgtc tcagcatcgc gggtgtgcca agcaggcgga ggccgtcact gccctggaac 4500
agcaggtggc atctctggac aagcatttgc gcaaccagcg gcaattcatg gatgagcagg 4560
cagccgagcg ggagcacgag cgcgaggagt tccagcagga gattcagagg ctggaggggc 4620
agctccgcca ggcggccaag ccgcagccct ggggccctcg cgacagccag caggcgccgc 4680
tggatggaga ggttgagttg ttacaacaaa agttgagaga aaagttggat gaatttaatg 4740
aattggctat acagaaagag tcggcagata gacaagtgtt aatgcaggaa gaagaaatta 4800
aacgtctgga ggagatgaac atcaacatca ggaaaaaagt ggcccagctc caggaagaag 4860
tggaaaaaca gaaaaacatc gtgaaagggc tggaacagga taaagaggtg ttaaagaaac 4920
agcagatgag tagcttgctt ctggcgtcca cgttgcagtc tacactagat gcaggcagat 4980
gtcccgagcc tccttcgggc agccctcctg agggtccaga aatacagtta gaggtgacac 5040
agagagcact cctgcggcgc gagagcgagg ttttggactt aaaagaacag ctagaaaaga 5100
tgaaaggtga cttagaaagt aaaaatgaag aaatactaca tctgaactta aaattggaca 5160
tgcagaacag ccagactgct gtcagcctca gagaacttga ggaagagaac acgagcttga 5220
aggtcatata taccagaagt tctgagattg aagagctgaa agccactatt gaaaatctgc 5280
aagagaatca gaaacgatta caaaaggaga aagcagagga aattgaacaa ctccatgaag 5340
tcattgagaa gctgcagcac gagctgtccc tcatggggcc tgtggtgcac gaagtcagcg 5400
acagtcaggc tggcagtctg cagagcgagc tgctctgctc ccaggccggg ggccctcgtg 5460
ggcaggccct acagggcgag ctcgaggctg cgctggaagc caaggaggcc ctgagccggc 5520
tgctggctga ccaggagcgc aggcacagcc aggccctgga ggccctgcag cagcgcctcc 5580
agggcgcaga ggaggctgcg gagctacagc tggctgagct ggagcgcaat gtagccctca 5640
gggaggctga ggtcgaagac atggcctccc ggatccagga gttcgaagcg gccctgaaag 5700
caaaggaagc gacgattgcc gagagaaatt tagaaatcga cgctctgaac cagcggaagg 5760
cggcccactc tgccgagctg gaggccgtcc tgttggcctt ggcccgcatc cgccgcgccc 5820
tggagcagca gcccctggca gccggggcgg cgcctcccga gctgcagtgg ctccgagcgc 5880
agtgtgcccg cctcagccgc cagctgcagg tgctgcacca gcggttcctg aggtgccagg 5940
tggagctgga caggcggcag gcccgcagag ccacagctca cacacgggtg cccggggccc 6000
acccacagcc tcgcatggat ggtggcgcca aggcccaggt caccggcgac gtggaggcct 6060
cccatgatgc tgctttggag ccggttgtcc ctgacccaca gggtgatctg cagcctgtcc 6120
tggtgacgtt gaaggatgca cctctctgca agcaagaagg cgtgatgtca gtgctcaccg 6180
tctgccagag gcagctgcag tcggagctgc tcttggtgaa aaatgaaatg cgcctgagtc 6240
tggaggacgg cggcaagggt aaagaaaaag tactggaaga ttgtcagctg ccgaaggtcg 6300
atctcgtagc tcaggtgaaa cagcttcagg aaaaactgaa ccgtttgctg tattccatga 6360
ccttccagaa tgtggatgct gccgacacca aatctctgtg gcccatggcc tcagcacacc 6420
tgttggagag cagctggagt gatgattcct gtgacggaga agagcctgac atatcacccc 6480
acatagacac atgtgatgcc aatacagcca cggggggtgt aactgatgtt atcaaaaatc 6540
aggccataga cgcgtgtgat gccaatacaa ccccaggggg tgtaactgat gttatcaaaa 6600
attgggattc cttgatacca gatgaaatgc cagattctcc cattcaagaa aaatcagaat 6660
gtcaggacat gtctctttct tcaccgacca gcgtacttgg tggctcccgc caccagagcc 6720
acactgcaga ggctgggccc cggaagagcc cggtcgggat gctggacctg tcttcctgga 6780
gctcccctga ggtcctcagg aaggactgga ccctggagcc ctggcccagc ctccccgtga 6840
caccccactc aggagccctg agcctgtgca gtgccgacac atccctgggg gacagggcgg 6900
acacctcgct gccacagacc caggggccgg ggctgctttg ttccccaggc gtgtctgcag 6960
cagcgctggc actgcagtgg gccgagtctc cgccggctga cgaccaccat gtgcagagga 7020
cggctgtgga gaaagatgtc gaagatttta tcacaacatc ctttgattct caagaaacat 7080
taagttcacc tcctcctgga ttagaaggaa aagctgatag aagtgagaaa agtgacggct 7140
cgggttttgg agcaagactg agcccggggt caggaggccc tgaggctcaa actgctggtc 7200
ctgtgacccc tgcttccatc tctggaaggt ttcagccgct gccggaagcc atgaaggaga 7260
aggaagtgcg tccgaagcac gtgaaggctt tactgcagat ggtgcgtgac gagagccacc 7320
agatcctggc gctgtcagaa ggccttgcac ccccaagcgg cgagccacac ccaccccgga 7380
aggaagacga gatacaggac atctcgctcc atgggggaaa gacgcaggaa gtgcccaccg 7440
cgtgccccga ttggagaggg gaccttctgc aggttgtgca agaggccttt gaaaaagagc 7500
aggagatgca gggggttgag ctgcagcccc gactcagtgg ctcagatctg gggggtcaca 7560
gctccctgct cgaaaggctg gagaagatca tccgtgagca gggagacctg caggaaaagt 7620
ccctggagca tcttcgcttg ccggaccgga gcagcctgct gtccgagatc caggcgctgc 7680
gtgcccagct gcgcatgacg cacctgcaga accaggagaa gctgcagcac ttgcgcacgg 7740
cgctgacaag cgcagaggcg cgcgggagcc agcaggagca ccagctgcgc aggcaggttg 7800
aactgctggc ttataaagta gagcaggaga agtgcattgc tggtgacttg cagaagacgc 7860
tgagtgaaga gcaagagaag gcaaacagcg tgcagaagct cctggcggcg gagcagactg 7920
tagtgcgaga tttgaagtcc gacctctgtg agagcaggca gaagagcgaa cagctgtccc 7980
ggtccctctg cgaggtgcag caggaggtcc tccagctgag atccatgctg agcagtaagg 8040
agaacgagct gaaggccgcg cttcaggagc tggagagtga gcaggggaag gggcgtgccc 8100
tgcagagcca gctggaggag gagcagctgc ggcacctgca gagggagagc cagagtgcca 8160
aggccctgga ggagctgcgg gcgtctttgg agacacagcg tgctcagagc agtcgactct 8220
gcgtggcact gaaacacgag cagacggcca aggacaacct gcagaaggag ctgcgtatcg 8280
agcactcacg ctgcgaggcc ttgctggctc aggagcggag ccagctctct gagctccaga 8340
aggaccttgc ggctgagaag agccgcaccc tggagctgtc agaggccttg cggcacgagc 8400
ggctcctgac cgagcagctg agccagagga cacaggaggc ttgcgtgcac caggacacac 8460
aggcccatca cgctctgctg cagaagctga aggaggagaa gtcccgggtg gtggacttgc 8520
aagcgatgct tgaaaaggtg cagcagcaag ccctgcattc tcagcagcag cttgaggctg 8580
aggctcagaa gcactgtgag gcgctcagga gagagaagga ggtaagtgcc acactgaagt 8640
cgacggtgga agccctgcac acccaaaaac gagagctgag atgctctctg gagagagaga 8700
gggagaaacc agcgtggttg caggcagaat tagagcagtc acacccacgg ttgaaagagc 8760
aagaaggacg caaggctgcg aggaggagcg cggaggccag gcagagccca gcggctgcgg 8820
agcagtggag gaagtggcag agagacaagg agaagctgcg agaattagaa ctgcagcgtc 8880
agcgtgactt gcataagatc aagcagcttc agcagacagt gagagacctg gagtcgaagg 8940
acgaggtgcc tggcagccgc ctccacctag gttctgcccg cagggctgcc ggctcggatg 9000
cggaccacct ccgggaacag cagcgagagc tggaggcgat gaggcagcgg ctgctctctg 9060
ccgcccggct tctcaccagc ttcaccagcc aggccgtgga caggacagtt aatgattgga 9120
cgtcatccaa tgagaaagca gtgatgtctt tactgcacac gttggaggag ctgaagtctg 9180
acttgagcag gcccacctcc tcccagaaaa aaatggcagc agagctgcag ttccagtttg 9240
tggacgtcct gctgaaagac aatgtttccc tcacaaaagc gctcagcacg gtgacccagg 9300
agaagctgga gctgagcaga gccgtgtcta agcttgagaa gttgctgaag caccatctgc 9360
agaagggctg cagcccaagc aggtcggaaa ggtctgcttg gaagccagac gaaacggctc 9420
cacagagttc cctgaggcgc ccagaccccg gccggcttcc accagctgcc agcgaggaag 9480
cacacaccag caatgtcaag atggaaaaat tgtacctgca ttacttgaga gcagagagct 9540
ttagaaaagc tctgatttat caaaagaagt atcttttgct gttgattggt ggattccagg 9600
attctgaaca agaaacactc tccatgattg cccatttggg ggtatttcct tccaaagcag 9660
aacggaaaat cacatctcgt cctttcacca ggttccgcac ggccgtcagg gtggtcattg 9720
caatattaag attacgtttt ttggttaaga aatggcaaga agtagatcgg aaaggagctc 9780
tggcacaagg caaagcccct cgcccagggc cccgagcacg acagccgcag tctccaccca 9840
gaaccagaga gtccccccca acccgggatg taccctctgg ccacaccagg gaccctgcca 9900
gaggccgcag actggcagca gcagcctccc cacacagtgg gggaagagcc actccatccc 9960
caaattcaag attagaaaga tccctgactg cttctcaaga tccagaacat tccttgacag 10020
agtatattca ccatttagaa gtgatccagc aaagattggg aggggtacta ccagattcta 10080
cttcaaagaa atcctgccac ccgatgatta aacagtgaat aaaatgtcat ggctctttcc 10140
tgcgacaatt ctatttgagg aaaagatttg tttttccctt ttcccaagga agctcgtggg 10200
acagcatggg cactactctt catgtgcggt gacaccagcc cccagatgcc ttgaattaag 10260
tgtcctcacc tttatgcatg actgcaaagc cagctggagc attttctatg gagcctccgt 10320
atgttttagg cccatgacct tcgtgaggtg acgggcactc actcccatga gccctggctg 10380
tgtgctgttg tgtgcctatc ggcagatcca tccttcctgc ctccaaggag gatacacaga 10440
gaatggcttc ctgttgtttt gtttattttc ttaacgtgta cagatggaaa cttcatttaa 10500
aaataaaaac aaaacaactc aaaaaggaat aaaatttaat cactgttttg tttgtgaata 10560
aaaaaaaaaa aaa                                                    10573



<210> 38
<211> 3336
<212> PRT
<213> Homo sapiens

<400> 38
Met Glu Val Glu Gln Glu Gln Arg Arg Arg Lys Val Glu Ala Gly Arg
 1               5                  10                  15      
Thr Lys Leu Ala His Phe Arg Gln Arg Lys Thr Lys Gly Asp Ser Ser
            20                  25                  30          
His Ser Glu Lys Lys Thr Ala Lys Arg Lys Gly Ser Ala Val Asp Ala
        35                  40                  45              
Ser Val Gln Glu Glu Ser Pro Val Thr Lys Glu Asp Ser Ala Leu Cys
    50                  55                  60                  
Gly Gly Gly Asp Ile Cys Lys Ser Thr Ser Cys Asp Asp Thr Pro Asp
65                  70                  75                  80  
Gly Ala Gly Gly Ala Phe Ala Ala Gln Pro Glu Asp Cys Asp Gly Glu
                85                  90                  95      
Lys Arg Glu Asp Leu Glu Gln Leu Gln Gln Lys Gln Val Asn Asp His
            100                 105                 110         
Pro Pro Glu Gln Cys Gly Met Phe Thr Val Ser Asp His Pro Pro Glu
        115                 120                 125             
Gln His Gly Met Phe Thr Val Gly Asp His Pro Pro Glu Gln Arg Gly
    130                 135                 140                 
Met Phe Thr Val Ser Asp His Pro Pro Glu Gln His Gly Met Phe Thr
145                 150                 155                 160 
Val Ser Asp His Pro Pro Glu Gln Arg Gly Met Phe Thr Ile Ser Asp
                165                 170                 175     
His Gln Pro Glu Gln Arg Gly Met Phe Thr Val Ser Asp His Thr Pro
            180                 185                 190         
Glu Gln Arg Gly Ile Phe Thr Ile Ser Asp His Pro Ala Glu Gln Arg
        195                 200                 205             
Gly Met Phe Thr Lys Glu Cys Glu Gln Glu Cys Glu Leu Ala Ile Thr
    210                 215                 220                 
Asp Leu Glu Ser Gly Arg Glu Asp Glu Ala Gly Leu His Gln Ser Gln
225                 230                 235                 240 
Ala Val His Gly Leu Glu Leu Glu Ala Leu Arg Leu Ser Leu Ser Asn
                245                 250                 255     
Met His Thr Ala Gln Leu Glu Leu Thr Gln Ala Asn Leu Gln Lys Glu
            260                 265                 270         
Lys Glu Thr Ala Leu Thr Glu Leu Arg Glu Met Leu Asn Ser Arg Arg
        275                 280                 285             
Ala Gln Glu Leu Ala Leu Leu Gln Ser Arg Gln Gln His Glu Leu Glu
    290                 295                 300                 
Leu Leu Arg Glu Gln His Ala Arg Glu Lys Glu Glu Val Val Leu Arg
305                 310                 315                 320 
Cys Gly Gln Glu Ala Ala Glu Leu Lys Glu Lys Leu Gln Ser Glu Met
                325                 330                 335     
Glu Lys Asn Ala Gln Ile Val Lys Thr Leu Lys Glu Asp Trp Glu Ser
            340                 345                 350         
Glu Lys Asp Leu Cys Leu Glu Asn Leu Arg Lys Glu Leu Ser Ala Lys
        355                 360                 365             
His Gln Ser Glu Met Glu Asp Leu Gln Asn Gln Phe Gln Lys Glu Leu
    370                 375                 380                 
Ala Glu Gln Arg Ala Glu Leu Glu Lys Ile Phe Gln Asp Lys Asn Gln
385                 390                 395                 400 
Ala Glu Arg Ala Leu Arg Asn Leu Glu Ser His His Gln Ala Ala Ile
                405                 410                 415     
Glu Lys Leu Arg Glu Asp Leu Gln Ser Glu His Gly Arg Cys Leu Glu
            420                 425                 430         
Asp Leu Glu Phe Lys Phe Lys Glu Ser Glu Lys Glu Lys Gln Leu Glu
        435                 440                 445             
Leu Glu Asn Leu Gln Ala Ser Tyr Glu Asp Leu Lys Ala Gln Ser Gln
    450                 455                 460                 
Glu Glu Ile Arg Arg Leu Trp Ser Gln Leu Asp Ser Ala Arg Thr Ser
465                 470                 475                 480 
Arg Gln Glu Leu Ser Glu Leu His Glu Gln Leu Leu Ala Arg Thr Ser
                485                 490                 495     
Arg Val Glu Asp Leu Glu Gln Leu Lys Gln Arg Glu Lys Thr Gln His
            500                 505                 510         
Glu Ser Glu Leu Glu Gln Leu Arg Ile Tyr Phe Glu Lys Lys Leu Arg
        515                 520                 525             
Asp Ala Glu Lys Thr Tyr Gln Glu Asp Leu Thr Leu Leu Gln Gln Arg
    530                 535                 540                 
Leu Gln Gly Ala Arg Glu Asp Ala Leu Leu Asp Ser Val Glu Val Gly
545                 550                 555                 560 
Leu Ser Cys Val Gly Leu Glu Glu Lys Pro Glu Lys Gly Arg Lys Asp
                565                 570                 575     
His Val Asp Glu Leu Glu Pro Glu Arg His Lys Glu Ser Leu Pro Arg
            580                 585                 590         
Phe Gln Ala Glu Leu Glu Glu Ser His Arg His Gln Leu Glu Ala Leu
        595                 600                 605             
Glu Ser Pro Leu Cys Ile Gln His Glu Gly His Val Ser Asp Arg Cys
    610                 615                 620                 
Cys Val Glu Thr Ser Ala Leu Gly His Glu Trp Arg Leu Glu Pro Ser
625                 630                 635                 640 
Glu Gly His Ser Gln Glu Leu Pro Trp Val His Leu Gln Gly Val Gln
                645                 650                 655     
Asp Gly Asp Leu Glu Ala Asp Thr Glu Arg Ala Ala Arg Val Leu Gly
            660                 665                 670         
Leu Glu Thr Glu His Lys Val Gln Leu Ser Leu Leu Gln Thr Glu Leu
        675                 680                 685             
Lys Glu Glu Ile Glu Leu Leu Lys Ile Glu Asn Arg Asn Leu Tyr Gly
    690                 695                 700                 
Lys Leu Gln His Glu Thr Arg Leu Lys Asp Asp Leu Glu Lys Val Lys
705                 710                 715                 720 
His Asn Leu Ile Glu Asp His Gln Lys Glu Leu Asn Asn Ala Lys Gln
                725                 730                 735     
Lys Thr Glu Leu Met Lys Gln Glu Phe Gln Arg Lys Glu Thr Asp Trp
            740                 745                 750         
Lys Val Met Lys Glu Glu Leu Gln Arg Glu Ala Glu Glu Lys Leu Thr
        755                 760                 765             
Leu Met Leu Leu Glu Leu Arg Glu Lys Ala Glu Ser Glu Lys Gln Thr
    770                 775                 780                 
Ile Ile Asn Lys Phe Glu Leu Arg Glu Ala Glu Met Arg Gln Leu Gln
785                 790                 795                 800 
Asp Gln Gln Ala Ala Gln Ile Leu Asp Leu Glu Arg Ser Leu Thr Glu
                805                 810                 815     
Gln Gln Gly Arg Leu Gln Gln Leu Glu Gln Asp Leu Thr Ser Asp Asp
            820                 825                 830         
Ala Leu His Cys Ser Gln Cys Gly Arg Glu Pro Pro Thr Ala Gln Asp
        835                 840                 845             
Gly Glu Leu Ala Ala Leu His Val Lys Glu Asp Cys Ala Leu Gln Leu
    850                 855                 860                 
Met Leu Ala Arg Ser Arg Phe Leu Glu Glu Arg Lys Glu Ile Thr Glu
865                 870                 875                 880 
Lys Phe Ser Ala Glu Gln Asp Ala Phe Leu Gln Glu Ala Gln Glu Gln
                885                 890                 895     
His Ala Arg Glu Leu Gln Leu Leu Gln Glu Arg His Gln Gln Gln Leu
            900                 905                 910         
Leu Ser Val Thr Ala Glu Leu Glu Ala Arg His Gln Ala Ala Leu Gly
        915                 920                 925             
Glu Leu Thr Ala Ser Leu Glu Ser Lys Gln Gly Ala Leu Leu Ala Ala
    930                 935                 940                 
Arg Val Ala Glu Leu Gln Thr Lys His Ala Ala Asp Leu Gly Ala Leu
945                 950                 955                 960 
Glu Thr Arg His Leu Ser Ser Leu Asp Ser Leu Glu Ser Cys Tyr Leu
                965                 970                 975     
Ser Glu Phe Gln Thr Ile Arg Glu Glu His Arg Gln Ala Leu Glu Leu
            980                 985                 990         
Leu Arg Ala Asp Phe Glu Glu Gln Leu Trp Lys Lys Asp Ser Leu His
        995                 1000                1005            
Gln Thr Ile Leu Thr Gln Glu Leu Glu Lys Leu Lys Arg Lys His Glu
    1010                1015                1020                
Gly Glu Leu Gln Ser Val Arg Asp His Leu Arg Thr Glu Val Ser Thr
1025                1030                1035               1040 
Glu Leu Ala Gly Thr Val Ala His Glu Leu Gln Gly Val His Gln Gly
                1045                1050                1055    
Glu Phe Gly Ser Glu Lys Lys Thr Ala Leu His Glu Lys Glu Glu Thr
            1060                1065                1070        
Leu Arg Leu Gln Ser Ala Gln Ala Gln Pro Phe His Gln Glu Glu Lys
        1075                1080                1085            
Glu Ser Leu Ser Leu Gln Leu Gln Lys Lys Asn His Gln Val Gln Gln
    1090                1095                1100                
Leu Lys Asp Gln Val Leu Ser Leu Ser His Glu Ile Glu Glu Cys Arg
1105                1110                1115               1120 
Ser Glu Leu Glu Val Leu Gln Gln Arg Arg Glu Arg Glu Asn Arg Glu
                1125                1130                1135    
Gly Ala Asn Leu Leu Ser Met Leu Lys Ala Asp Val Asn Leu Ser His
            1140                1145                1150        
Ser Glu Arg Gly Ala Leu Gln Asp Ala Leu Arg Arg Leu Leu Gly Leu
        1155                1160                1165            
Phe Gly Glu Thr Leu Arg Ala Ala Val Thr Leu Arg Ser Arg Ile Gly
    1170                1175                1180                
Glu Arg Val Gly Leu Cys Leu Asp Asp Ala Gly Ala Gly Leu Ala Leu
1185                1190                1195               1200 
Ser Thr Ala Pro Ala Leu Glu Glu Thr Trp Ser Asp Val Ala Leu Pro
                1205                1210                1215    
Glu Leu Asp Arg Thr Leu Ser Glu Cys Ala Glu Met Ser Ser Val Ala
            1220                1225                1230        
Glu Ile Ser Ser His Met Arg Glu Ser Phe Leu Met Ser Pro Glu Ser
        1235                1240                1245            
Val Arg Glu Cys Glu Gln Pro Ile Arg Arg Val Phe Gln Ser Leu Ser
    1250                1255                1260                
Leu Ala Val Asp Gly Leu Met Glu Met Ala Leu Asp Ser Ser Arg Gln
1265                1270                1275               1280 
Leu Glu Glu Ala Arg Gln Ile His Ser Arg Phe Glu Lys Glu Phe Ser
                1285                1290                1295    
Phe Lys Asn Glu Glu Thr Ala Gln Val Val Arg Lys His Gln Glu Leu
            1300                1305                1310        
Leu Glu Cys Leu Lys Glu Glu Ser Ala Ala Lys Ala Glu Leu Ala Leu
        1315                1320                1325            
Glu Leu His Lys Thr Gln Gly Thr Leu Glu Gly Phe Lys Val Glu Thr
    1330                1335                1340                
Ala Asp Leu Lys Glu Val Leu Ala Gly Lys Glu Asp Ser Glu His Arg
1345                1350                1355               1360 
Leu Val Leu Glu Leu Glu Ser Leu Arg Arg Gln Leu Gln Gln Ala Ala
                1365                1370                1375    
Gln Glu Gln Ala Ala Leu Arg Glu Glu Cys Thr Arg Leu Trp Ser Arg
            1380                1385                1390        
Gly Glu Ala Thr Ala Thr Asp Ala Glu Ala Arg Glu Ala Ala Leu Arg
        1395                1400                1405            
Lys Glu Val Glu Asp Leu Thr Lys Glu Gln Ser Glu Thr Arg Lys Gln
    1410                1415                1420                
Ala Glu Lys Asp Arg Ser Ala Leu Leu Ser Gln Met Lys Ile Leu Glu
1425                1430                1435               1440 
Ser Glu Leu Glu Glu Gln Leu Ser Gln His Arg Gly Cys Ala Lys Gln
                1445                1450                1455    
Ala Glu Ala Val Thr Ala Leu Glu Gln Gln Val Ala Ser Leu Asp Lys
            1460                1465                1470        
His Leu Arg Asn Gln Arg Gln Phe Met Asp Glu Gln Ala Ala Glu Arg
        1475                1480                1485            
Glu His Glu Arg Glu Glu Phe Gln Gln Glu Ile Gln Arg Leu Glu Gly
    1490                1495                1500                
Gln Leu Arg Gln Ala Ala Lys Pro Gln Pro Trp Gly Pro Arg Asp Ser
1505                1510                1515               1520 
Gln Gln Ala Pro Leu Asp Gly Glu Val Glu Leu Leu Gln Gln Lys Leu
                1525                1530                1535    
Arg Glu Lys Leu Asp Glu Phe Asn Glu Leu Ala Ile Gln Lys Glu Ser
            1540                1545                1550        
Ala Asp Arg Gln Val Leu Met Gln Glu Glu Glu Ile Lys Arg Leu Glu
        1555                1560                1565            
Glu Met Asn Ile Asn Ile Arg Lys Lys Val Ala Gln Leu Gln Glu Glu
    1570                1575                1580                
Val Glu Lys Gln Lys Asn Ile Val Lys Gly Leu Glu Gln Asp Lys Glu
1585                1590                1595               1600 
Val Leu Lys Lys Gln Gln Met Ser Ser Leu Leu Leu Ala Ser Thr Leu
                1605                1610                1615    
Gln Ser Thr Leu Asp Ala Gly Arg Cys Pro Glu Pro Pro Ser Gly Ser
            1620                1625                1630        
Pro Pro Glu Gly Pro Glu Ile Gln Leu Glu Val Thr Gln Arg Ala Leu
        1635                1640                1645            
Leu Arg Arg Glu Ser Glu Val Leu Asp Leu Lys Glu Gln Leu Glu Lys
    1650                1655                1660                
Met Lys Gly Asp Leu Glu Ser Lys Asn Glu Glu Ile Leu His Leu Asn
1665                1670                1675               1680 
Leu Lys Leu Asp Met Gln Asn Ser Gln Thr Ala Val Ser Leu Arg Glu
                1685                1690                1695    
Leu Glu Glu Glu Asn Thr Ser Leu Lys Val Ile Tyr Thr Arg Ser Ser
            1700                1705                1710        
Glu Ile Glu Glu Leu Lys Ala Thr Ile Glu Asn Leu Gln Glu Asn Gln
        1715                1720                1725            
Lys Arg Leu Gln Lys Glu Lys Ala Glu Glu Ile Glu Gln Leu His Glu
    1730                1735                1740                
Val Ile Glu Lys Leu Gln His Glu Leu Ser Leu Met Gly Pro Val Val
1745                1750                1755               1760 
His Glu Val Ser Asp Ser Gln Ala Gly Ser Leu Gln Ser Glu Leu Leu
                1765                1770                1775    
Cys Ser Gln Ala Gly Gly Pro Arg Gly Gln Ala Leu Gln Gly Glu Leu
            1780                1785                1790        
Glu Ala Ala Leu Glu Ala Lys Glu Ala Leu Ser Arg Leu Leu Ala Asp
        1795                1800                1805            
Gln Glu Arg Arg His Ser Gln Ala Leu Glu Ala Leu Gln Gln Arg Leu
    1810                1815                1820                
Gln Gly Ala Glu Glu Ala Ala Glu Leu Gln Leu Ala Glu Leu Glu Arg
1825                1830                1835               1840 
Asn Val Ala Leu Arg Glu Ala Glu Val Glu Asp Met Ala Ser Arg Ile
                1845                1850                1855    
Gln Glu Phe Glu Ala Ala Leu Lys Ala Lys Glu Ala Thr Ile Ala Glu
            1860                1865                1870        
Arg Asn Leu Glu Ile Asp Ala Leu Asn Gln Arg Lys Ala Ala His Ser
        1875                1880                1885            
Ala Glu Leu Glu Ala Val Leu Leu Ala Leu Ala Arg Ile Arg Arg Ala
    1890                1895                1900                
Leu Glu Gln Gln Pro Leu Ala Ala Gly Ala Ala Pro Pro Glu Leu Gln
1905                1910                1915               1920 
Trp Leu Arg Ala Gln Cys Ala Arg Leu Ser Arg Gln Leu Gln Val Leu
                1925                1930                1935    
His Gln Arg Phe Leu Arg Cys Gln Val Glu Leu Asp Arg Arg Gln Ala
            1940                1945                1950        
Arg Arg Ala Thr Ala His Thr Arg Val Pro Gly Ala His Pro Gln Pro
        1955                1960                1965            
Arg Met Asp Gly Gly Ala Lys Ala Gln Val Thr Gly Asp Val Glu Ala
    1970                1975                1980                
Ser His Asp Ala Ala Leu Glu Pro Val Val Pro Asp Pro Gln Gly Asp
1985                1990                1995               2000 
Leu Gln Pro Val Leu Val Thr Leu Lys Asp Ala Pro Leu Cys Lys Gln
                2005                2010                2015    
Glu Gly Val Met Ser Val Leu Thr Val Cys Gln Arg Gln Leu Gln Ser
            2020                2025                2030        
Glu Leu Leu Leu Val Lys Asn Glu Met Arg Leu Ser Leu Glu Asp Gly
        2035                2040                2045            
Gly Lys Gly Lys Glu Lys Val Leu Glu Asp Cys Gln Leu Pro Lys Val
    2050                2055                2060                
Asp Leu Val Ala Gln Val Lys Gln Leu Gln Glu Lys Leu Asn Arg Leu
2065                2070                2075               2080 
Leu Tyr Ser Met Thr Phe Gln Asn Val Asp Ala Ala Asp Thr Lys Ser
                2085                2090                2095    
Leu Trp Pro Met Ala Ser Ala His Leu Leu Glu Ser Ser Trp Ser Asp
            2100                2105                2110        
Asp Ser Cys Asp Gly Glu Glu Pro Asp Ile Ser Pro His Ile Asp Thr
        2115                2120                2125            
Cys Asp Ala Asn Thr Ala Thr Gly Gly Val Thr Asp Val Ile Lys Asn
    2130                2135                2140                
Gln Ala Ile Asp Ala Cys Asp Ala Asn Thr Thr Pro Gly Gly Val Thr
2145                2150                2155               2160 
Asp Val Ile Lys Asn Trp Asp Ser Leu Ile Pro Asp Glu Met Pro Asp
                2165                2170                2175    
Ser Pro Ile Gln Glu Lys Ser Glu Cys Gln Asp Met Ser Leu Ser Ser
            2180                2185                2190        
Pro Thr Ser Val Leu Gly Gly Ser Arg His Gln Ser His Thr Ala Glu
        2195                2200                2205            
Ala Gly Pro Arg Lys Ser Pro Val Gly Met Leu Asp Leu Ser Ser Trp
    2210                2215                2220                
Ser Ser Pro Glu Val Leu Arg Lys Asp Trp Thr Leu Glu Pro Trp Pro
2225                2230                2235               2240 
Ser Leu Pro Val Thr Pro His Ser Gly Ala Leu Ser Leu Cys Ser Ala
                2245                2250                2255    
Asp Thr Ser Leu Gly Asp Arg Ala Asp Thr Ser Leu Pro Gln Thr Gln
            2260                2265                2270        
Gly Pro Gly Leu Leu Cys Ser Pro Gly Val Ser Ala Ala Ala Leu Ala
        2275                2280                2285            
Leu Gln Trp Ala Glu Ser Pro Pro Ala Asp Asp His His Val Gln Arg
    2290                2295                2300                
Thr Ala Val Glu Lys Asp Val Glu Asp Phe Ile Thr Thr Ser Phe Asp
2305                2310                2315               2320 
Ser Gln Glu Thr Leu Ser Ser Pro Pro Pro Gly Leu Glu Gly Lys Ala
                2325                2330                2335    
Asp Arg Ser Glu Lys Ser Asp Gly Ser Gly Phe Gly Ala Arg Leu Ser
            2340                2345                2350        
Pro Gly Ser Gly Gly Pro Glu Ala Gln Thr Ala Gly Pro Val Thr Pro
        2355                2360                2365            
Ala Ser Ile Ser Gly Arg Phe Gln Pro Leu Pro Glu Ala Met Lys Glu
    2370                2375                2380                
Lys Glu Val Arg Pro Lys His Val Lys Ala Leu Leu Gln Met Val Arg
2385                2390                2395               2400 
Asp Glu Ser His Gln Ile Leu Ala Leu Ser Glu Gly Leu Ala Pro Pro
                2405                2410                2415    
Ser Gly Glu Pro His Pro Pro Arg Lys Glu Asp Glu Ile Gln Asp Ile
            2420                2425                2430        
Ser Leu His Gly Gly Lys Thr Gln Glu Val Pro Thr Ala Cys Pro Asp
        2435                2440                2445            
Trp Arg Gly Asp Leu Leu Gln Val Val Gln Glu Ala Phe Glu Lys Glu
    2450                2455                2460                
Gln Glu Met Gln Gly Val Glu Leu Gln Pro Arg Leu Ser Gly Ser Asp
2465                2470                2475               2480 
Leu Gly Gly His Ser Ser Leu Leu Glu Arg Leu Glu Lys Ile Ile Arg
                2485                2490                2495    
Glu Gln Gly Asp Leu Gln Glu Lys Ser Leu Glu His Leu Arg Leu Pro
            2500                2505                2510        
Asp Arg Ser Ser Leu Leu Ser Glu Ile Gln Ala Leu Arg Ala Gln Leu
        2515                2520                2525            
Arg Met Thr His Leu Gln Asn Gln Glu Lys Leu Gln His Leu Arg Thr
    2530                2535                2540                
Ala Leu Thr Ser Ala Glu Ala Arg Gly Ser Gln Gln Glu His Gln Leu
2545                2550                2555               2560 
Arg Arg Gln Val Glu Leu Leu Ala Tyr Lys Val Glu Gln Glu Lys Cys
                2565                2570                2575    
Ile Ala Gly Asp Leu Gln Lys Thr Leu Ser Glu Glu Gln Glu Lys Ala
            2580                2585                2590        
Asn Ser Val Gln Lys Leu Leu Ala Ala Glu Gln Thr Val Val Arg Asp
        2595                2600                2605            
Leu Lys Ser Asp Leu Cys Glu Ser Arg Gln Lys Ser Glu Gln Leu Ser
    2610                2615                2620                
Arg Ser Leu Cys Glu Val Gln Gln Glu Val Leu Gln Leu Arg Ser Met
2625                2630                2635               2640 
Leu Ser Ser Lys Glu Asn Glu Leu Lys Ala Ala Leu Gln Glu Leu Glu
                2645                2650                2655    
Ser Glu Gln Gly Lys Gly Arg Ala Leu Gln Ser Gln Leu Glu Glu Glu
            2660                2665                2670        
Gln Leu Arg His Leu Gln Arg Glu Ser Gln Ser Ala Lys Ala Leu Glu
        2675                2680                2685            
Glu Leu Arg Ala Ser Leu Glu Thr Gln Arg Ala Gln Ser Ser Arg Leu
    2690                2695                2700                
Cys Val Ala Leu Lys His Glu Gln Thr Ala Lys Asp Asn Leu Gln Lys
2705                2710                2715               2720 
Glu Leu Arg Ile Glu His Ser Arg Cys Glu Ala Leu Leu Ala Gln Glu
                2725                2730                2735    
Arg Ser Gln Leu Ser Glu Leu Gln Lys Asp Leu Ala Ala Glu Lys Ser
            2740                2745                2750        
Arg Thr Leu Glu Leu Ser Glu Ala Leu Arg His Glu Arg Leu Leu Thr
        2755                2760                2765            
Glu Gln Leu Ser Gln Arg Thr Gln Glu Ala Cys Val His Gln Asp Thr
    2770                2775                2780                
Gln Ala His His Ala Leu Leu Gln Lys Leu Lys Glu Glu Lys Ser Arg
2785                2790                2795               2800 
Val Val Asp Leu Gln Ala Met Leu Glu Lys Val Gln Gln Gln Ala Leu
                2805                2810                2815    
His Ser Gln Gln Gln Leu Glu Ala Glu Ala Gln Lys His Cys Glu Ala
            2820                2825                2830        
Leu Arg Arg Glu Lys Glu Val Ser Ala Thr Leu Lys Ser Thr Val Glu
        2835                2840                2845            
Ala Leu His Thr Gln Lys Arg Glu Leu Arg Cys Ser Leu Glu Arg Glu
    2850                2855                2860                
Arg Glu Lys Pro Ala Trp Leu Gln Ala Glu Leu Glu Gln Ser His Pro
2865                2870                2875               2880 
Arg Leu Lys Glu Gln Glu Gly Arg Lys Ala Ala Arg Arg Ser Ala Glu
                2885                2890                2895    
Ala Arg Gln Ser Pro Ala Ala Ala Glu Gln Trp Arg Lys Trp Gln Arg
            2900                2905                2910        
Asp Lys Glu Lys Leu Arg Glu Leu Glu Leu Gln Arg Gln Arg Asp Leu
        2915                2920                2925            
His Lys Ile Lys Gln Leu Gln Gln Thr Val Arg Asp Leu Glu Ser Lys
    2930                2935                2940                
Asp Glu Val Pro Gly Ser Arg Leu His Leu Gly Ser Ala Arg Arg Ala
2945                2950                2955               2960 
Ala Gly Ser Asp Ala Asp His Leu Arg Glu Gln Gln Arg Glu Leu Glu
                2965                2970                2975    
Ala Met Arg Gln Arg Leu Leu Ser Ala Ala Arg Leu Leu Thr Ser Phe
            2980                2985                2990        
Thr Ser Gln Ala Val Asp Arg Thr Val Asn Asp Trp Thr Ser Ser Asn
        2995                3000                3005            
Glu Lys Ala Val Met Ser Leu Leu His Thr Leu Glu Glu Leu Lys Ser
    3010                3015                3020                
Asp Leu Ser Arg Pro Thr Ser Ser Gln Lys Lys Met Ala Ala Glu Leu
3025                3030                3035               3040 
Gln Phe Gln Phe Val Asp Val Leu Leu Lys Asp Asn Val Ser Leu Thr
                3045                3050                3055    
Lys Ala Leu Ser Thr Val Thr Gln Glu Lys Leu Glu Leu Ser Arg Ala
            3060                3065                3070        
Val Ser Lys Leu Glu Lys Leu Leu Lys His His Leu Gln Lys Gly Cys
        3075                3080                3085            
Ser Pro Ser Arg Ser Glu Arg Ser Ala Trp Lys Pro Asp Glu Thr Ala
    3090                3095                3100                
Pro Gln Ser Ser Leu Arg Arg Pro Asp Pro Gly Arg Leu Pro Pro Ala
3105                3110                3115               3120 
Ala Ser Glu Glu Ala His Thr Ser Asn Val Lys Met Glu Lys Leu Tyr
                3125                3130                3135    
Leu His Tyr Leu Arg Ala Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln
            3140                3145                3150        
Lys Lys Tyr Leu Leu Leu Leu Ile Gly Gly Phe Gln Asp Ser Glu Gln
        3155                3160                3165            
Glu Thr Leu Ser Met Ile Ala His Leu Gly Val Phe Pro Ser Lys Ala
    3170                3175                3180                
Glu Arg Lys Ile Thr Ser Arg Pro Phe Thr Arg Phe Arg Thr Ala Val
3185                3190                3195               3200 
Arg Val Val Ile Ala Ile Leu Arg Leu Arg Phe Leu Val Lys Lys Trp
                3205                3210                3215    
Gln Glu Val Asp Arg Lys Gly Ala Leu Ala Gln Gly Lys Ala Pro Arg
            3220                3225                3230        
Pro Gly Pro Arg Ala Arg Gln Pro Gln Ser Pro Pro Arg Thr Arg Glu
        3235                3240                3245            
Ser Pro Pro Thr Arg Asp Val Pro Ser Gly His Thr Arg Asp Pro Ala
    3250                3255                3260                
Arg Gly Arg Arg Leu Ala Ala Ala Ala Ser Pro His Ser Gly Gly Arg
3265                3270                3275               3280 
Ala Thr Pro Ser Pro Asn Ser Arg Leu Glu Arg Ser Leu Thr Ala Ser
                3285                3290                3295    
Gln Asp Pro Glu His Ser Leu Thr Glu Tyr Ile His His Leu Glu Val
            3300                3305                3310        
Ile Gln Gln Arg Leu Gly Gly Val Leu Pro Asp Ser Thr Ser Lys Lys
        3315                3320                3325            
Ser Cys His Pro Met Ile Lys Gln
    3330                3335    


<210> 39
<211> 4268
<212> DNA
<213> Homo sapiens

<400> 39
gccctgcgca ctccctgctg gggtgagcag cactgtaaag atgaagctgg ctaactggta 60
ctggctgagc tcagctgttc ttgccactta cggttttttg gttgtggcaa acaatgaaac 120
agaggaaatt aaagatgaaa gagcaaagga tgtctgccca gtgagactag aaagcagagg 180
gaaatgcgaa gaggcagggg agtgccccta ccaggtaagc ctgcccccct tgactattca 240
gctcccgaag caattcagca ggatcgagga ggtgttcaaa gaagtccaaa acctcaagga 300
aatcgtaaat agtctaaaga aatcttgcca agactgcaag ctgcaggctg atgacaacgg 360
agacccaggc agaaacggac tgttgttacc cagtacagga gccccgggag aggttggtga 420
taacagagtt agagaattag agagtgaggt taacaagctg tcctctgagc taaagaatgc 480
caaagaggag atcaatgtac ttcatggtcg cctggagaag ctgaatcttg taaatatgaa 540
caacatagaa aattatgttg acagcaaagt ggcaaatcta acatttgttg tcaatagttt 600
ggatggcaaa tgttcaaagt gtcccagcca agaacaaata cagtcacgtc cagttcaaca 660
tctaatatat aaagattgct ctgactacta cgcaataggc aaaagaagca gtgagaccta 720
cagagttaca cctgatccca aaaatagtag ctttgaagtt tactgtgaca tggagaccat 780
ggggggaggc tggacagtgc tgcaggcacg tctcgatggg agcaccaact tcaccagaac 840
atggcaagac tacaaagcag gctttggaaa cctcagaagg gaattttggc tggggaacga 900
taaaattcat cttctgacca agagtaagga aatgattctg agaatagatc ttgaagactt 960
taatggtgtc gaactatatg ccttgtatga tcagttttat gtggctaatg agtttctcaa 1020
atatcgttta cacgttggta actataatgg cacagctgga gatgcattac gtttcaacaa 1080
acattacaac cacgatctga agtttttcac cactccagat aaagacaatg atcgatatcc 1140
ttctgggaac tgtgggctgt actacagttc aggctggtgg tttgatgcat gtctttctgc 1200
aaacttaaat ggcaaatatt atcaccaaaa atacagaggt gtccgtaatg ggattttctg 1260
gggtacctgg cctggtgtaa gtgaggcaca ccctggtggc tacaagtcct ccttcaaaga 1320
ggctaagatg atgatcagac ccaagcactt taagccataa atcactctgt tcattcctcc 1380
aggtattcgt tatctaatag ggcaattaat tccttcagca ctttagaata tgccttgttt 1440
catatttttc atagctaaaa aatgatgtct gacggctagg ttcttatgct acacagcatt 1500
tgaaataaag ctgaaaaaca atgcatttta aaggagtcct ttgttgttat gctgttatcc 1560
aatgaacact tgcaagcaat tagcaatatt gagaattata cattagattt acaattcttt 1620
taatttctat tgaaactttt tctattgctt gtattacttg ctgtatttaa aaaataattg 1680
ttggctgggt gtggtagctc acgcctgtaa tcccagcact ttggaatgtc aaggcaggca 1740
gatcacttga ggtcaggagt ttgagaccag cctggccaaa catgtgaaac gctgtctcta 1800
ttaaaaatac aaaaattagc cgggcatggt ggtacatgcc tgtaatccta gctacttggg 1860
aggctgaggc aggagaatcg cttgaacctg agaggaagag gttgcagtga gccaagactg 1920
agccactgca ctccagcatg ggtgacagag aaaactctgt ctcaaacaaa aaaataataa 1980
aatttattca gtaggctgga ttctacacaa agtaatctgt atttgggcca tgatttaagc 2040
acatctgaag gtatatcact cttttcaggc tataattatt tgggtaatct tcattctgag 2100
acaaacttaa tctatatcat ttactttgca acagaacaac cctacagcat tttggttccc 2160
agactaaggg aactaatatc tatataatta aacttgttca tttatcattc atgaaatata 2220
aaatacttgt catttaaacc gtttaaaaat gtggtagcat aatgtcaccc caaaaagcat 2280
tcagaaagca atgtaactgt gaagaccagg gtttaaaggt aattcattta tagtttataa 2340
ctccttagat gtttgatgtt gaaaactgct ttaacatgaa aattatcttc ctctgctctg 2400
tgtgaacaat agcttttaat ttaagattgc tcactactgt actagactac tggtaggttt 2460
ttttgggggg ggtgggtagg gatatgtggg taatgaagca tttacttaca ggctatcata 2520
ctctgaggcc aattttatct ccaaagcaat aatatcatta agtgattcac ttcatagaag 2580
gctaagtttc tctaggacag atagaaaaca tgaattttga aatatataga acagtagtta 2640
aaatactata tatttcaacc ctggctggta gattgcttat tttactatca gaaactaaaa 2700
gatagatttt tacccaaaca gaagtatctg taatttttat aattcatcaa ttctggaatg 2760
ctatatataa tatttaaaag actttttaaa tgtgtttaat ttcatcatcg taaaaaggga 2820
tcatctcaga gagaacagca gtattctgcg tatttttaaa aatgctctag agtaacattt 2880
gaagtaattc actgtagtgt atgccagtcc tagaaataat ttttttaatt tctggtgtct 2940
gtttctaata cactaaccaa gttttcaaaa tatatttaca aagatgcatc tttacccatt 3000
attttaaaat gattaaggag gatagttgct tcaggtaaca agctaatttt tcaaatatta 3060
ggcccttaca gaactattta gtcaaaaagt aagatattcc tttaaaatat ataacccaaa 3120
gctttcagtt aaacatgata tatcacaaat actattaaaa tgttaaagag aaatgcaaat 3180
agcattaaat gatgaccaaa atgtaaaata ttgtagattt caaaagctgt gtctctatta 3240
ggtgggatac caaatgtaaa tgatgtaact gacgttgttt tttacttttt actttttaaa 3300
aaagactaaa aacgttttga tattatacaa tgtatttgtt tcagataagg tcattgtcat 3360
ttagtatata taattaatat atgtacaagt ttaagtaaat tcctgtgagt aaaaatggac 3420
ttatcacaaa acatagttct aaagaaaggt atatgctcat atacacggtg tccattaatt 3480
taatgggaac taggtataac ttcaggagaa tttggcaaat aattcattaa tccatgtaaa 3540
tattcaaaag cttgttctat ccacattatt tcaagggatc actttatttt tcattatact 3600
ttcacagcac ttttctagta aattctgtaa cacagaaatt ccattttgga atcatttcat 3660
gttaccaata attctagact tttataacat ttaacatgtt gatggaaata gattacatct 3720
gctagaacct tttgccttaa ctattcacca atatatgcta atattcataa atatggattg 3780
actgtttaca aacattagaa tcttgtcttg gttccatttt gatggctaat atttgttatc 3840
ttaattaaga ctatttctga ggtcatgatt acttgaaaat attgactaaa actgggtcct 3900
tagaaattcc aggtggagct gatttaccta tgactgaggg gaaaaaaaaa tcaaatttta 3960
ctgataatag taatgctcca aatgaattaa tgacacatct gttcaataaa taaagagctt 4020
aaatatacaa aacataagaa atctgggcaa caaaacttgt ggtctttact tttgaatagc 4080
tacccaagaa aaggttttaa aggtaaaagt tatgagtaat gtcatcacaa taagctcttg 4140
tttaaaattc ttttctttta tgtataatta ggtttatgtt tcatgtcttt ttaaaacctt 4200
ataaaagatt taattatcac atctattctt caatgtggaa atattaaata ttgttggttg 4260
taaaataa                                                          4268

<210> 40
<211> 439
<212> PRT
<213> Homo sapiens

<400> 40
Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr
 1               5                  10                  15      
Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp
            20                  25                  30          
Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys
        35                  40                  45              
Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu
    50                  55                  60                  
Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys
65                  70                  75                  80  
Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys
                85                  90                  95      
Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn
            100                 105                 110         
Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn
        115                 120                 125             
Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu
    130                 135                 140                 
Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys
145                 150                 155                 160 
Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys
                165                 170                 175     
Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser
            180                 185                 190         
Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu
        195                 200                 205             
Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser
    210                 215                 220                 
Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val
225                 230                 235                 240 
Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala
                245                 250                 255     
Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys
            260                 265                 270         
Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys
        275                 280                 285             
Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu
    290                 295                 300                 
Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr
305                 310                 315                 320 
Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn
                325                 330                 335     
Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp
            340                 345                 350         
Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser
        355                 360                 365             
Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys
    370                 375                 380                 
Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly
385                 390                 395                 400 
Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala
                405                 410                 415     
His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile
            420                 425                 430         
Arg Pro Lys His Phe Lys Pro
        435                 


<210> 41
<211> 4338
<212> DNA
<213> Homo sapiens

<400> 41
ggggcacact catgcattcc tgtcaagtca tcttgtgaaa ggctgcctgc ttccagcttg 60
gcttggatgt gcaaccttaa taaaactcac tgaggtctgg gagaaaatag cagatctgca 120
gcagataggg tagaggaaag ggtctagaat atgtacacgc agctgactca ggcaggctcc 180
atgctgaacg gtcacacaga gaggaaacaa taaatctcag ctactatgca ataaatatct 240
caagttttaa cgaagaaaaa catcattgca gtgaaataaa aaattttaaa attttagaac 300
aaagctaaca aatggctagt tttctatgat tcttcttcaa acgctttctt tgagggggaa 360
agagtcaaac aaacaagcag ttttacctga aataaagaac tagttttaga ggtcagaaga 420
aaggagcaag ttttgcgaga ggcacggaag gagtgtgctg gcagtacaat gacagttttc 480
ctttcctttg ctttcctcgc tgccattctg actcacatag ggtgcagcaa tcagcgccga 540
agtccagaaa acagtgggag aagatataac cggattcaac atgggcaatg tgcctacact 600
ttcattcttc cagaacacga tggcaactgt cgtgagagta cgacagacca gtacaacaca 660
aacgctctgc agagagatgc tccacacgtg gaaccggatt tctcttccca gaaacttcaa 720
catctggaac atgtgatgga aaattatact cagtggctgc aaaaacttga gaattacatt 780
gtggaaaaca tgaagtcgga gatggcccag atacagcaga atgcagttca gaaccacacg 840
gctaccatgc tggagatagg aaccagcctc ctctctcaga ctgcagagca gaccagaaag 900
ctgacagatg ttgagaccca ggtactaaat caaacttctc gacttgagat acagctgctg 960
gagaattcat tatccaccta caagctagag aagcaacttc ttcaacagac aaatgaaatc 1020
ttgaagatcc atgaaaaaaa cagtttatta gaacataaaa tcttagaaat ggaaggaaaa 1080
cacaaggaag agttggacac cttaaaggaa gagaaagaga accttcaagg cttggttact 1140
cgtcaaacat atataatcca ggagctggaa aagcaattaa acagagctac caccaacaac 1200
agtgtccttc agaagcagca actggagctg atggacacag tccacaacct tgtcaatctt 1260
tgcactaaag aaggtgtttt actaaaggga ggaaaaagag aggaagagaa accatttaga 1320
gactgtgcag atgtatatca agctggtttt aataaaagtg gaatctacac tatttatatt 1380
aataatatgc cagaacccaa aaaggtgttt tgcaatatgg atgtcaatgg gggaggttgg 1440
actgtaatac aacatcgtga agatggaagt ctagatttcc aaagaggctg gaaggaatat 1500
aaaatgggtt ttggaaatcc ctccggtgaa tattggctgg ggaatgagtt tatttttgcc 1560
attaccagtc agaggcagta catgctaaga attgagttaa tggactggga agggaaccga 1620
gcctattcac agtatgacag attccacata ggaaatgaaa agcaaaacta taggttgtat 1680
ttaaaaggtc acactgggac agcaggaaaa cagagcagcc tgatcttaca cggtgctgat 1740
ttcagcacta aagatgctga taatgacaac tgtatgtgca aatgtgccct catgttaaca 1800
ggaggatggt ggtttgatgc ttgtggcccc tccaatctaa atggaatgtt ctatactgcg 1860
ggacaaaacc atggaaaact gaatgggata aagtggcact acttcaaagg gcccagttac 1920
tccttacgtt ccacaactat gatgattcga cctttagatt tttgaaagcg caatgtcaga 1980
agcgattatg aaagcaacaa agaaatccgg agaagctgcc aggtgagaaa ctgtttgaaa 2040
acttcagaag caaacaatat tgtctccctt ccagcaataa gtggtagtta tgtgaagtca 2100
ccaaggttct tgaccgtgaa tctggagccg tttgagttca caagagtctc tacttggggt 2160
gacagtgctc acgtggctcg actatagaaa actccactga ctgtcgggct ttaaaaaggg 2220
aagaaactgc tgagcttgct gtgcttcaaa ctactactgg accttatttt ggaactatgg 2280
tagccagatg ataaatatgg ttaatttcat gtaaaacaga aaaaaagagt gaaaaagaga 2340
atatacatga agaatagaaa caagcctgcc ataatccttt ggaaaagatg tattatacca 2400
gtgaaaaggt gttatatcta tgcaaaccta ctaacaaatt atactgttgc acaattttga 2460
taaaaattta gaacagcatt gtcctctgag ttggttaaat gttaatggat ttcagaagcc 2520
taattccagt atcatactta ctagttgatt tctgcttacc catcttcaaa tgaaaattcc 2580
atttttgtaa gccataatga actgtagtac atggacaata agtgtgtggt agaaacaaac 2640
tccattactc tgatttttga tacagttttc agaaaaagaa atgaacataa tcaagtaagg 2700
atgtatgtgg tgaaaactta ccacccccat actatggttt tcatttactc taaaaactga 2760
ttgaatgata tataaatata tttatagcct gagtaaagtt aaaagaatgt aaaatatatc 2820
atcaagttct taaaataata tacatgcatt taatatttcc tttgatatta tacaggaaag 2880
caatattttg gagtatgtta agttgaagta aaagcaagta ctctggagca gttcatttta 2940
cagtatctac ttgcatgtgt atacatacat gtaacttcat tattttaaaa atatttttag 3000
aactccaata ctcaccctgt tatgtcttgc taatttaaat tttgctaatt aactgaaaca 3060
tgcttaccag attcacactg ttccagtgtc tataaaagaa acactttgaa gtctataaaa 3120
aataaaataa ttataaatat cattgtacat agcatgttta tatctgcaaa aaacctaata 3180
gctaattaat ctggaatatg caacattgtc cttaattgat gcaaataaca caaatgctca 3240
aagaaatcta ctatatccct taatgaaata catcattctt catatatttc tccttcagtc 3300
cattccctta ggcaattttt aatttttaaa aattattatc aggggagaaa aattggcaaa 3360
actattatat gtaagggaaa tatatacaaa aagaaaatta atcatagtca cctgactaag 3420
aaattctgac tgctagttgc cataaataac tcaatggaaa tattcctatg ggataatgta 3480
ttttaagtga atttttgggg tgcttgaagt tactgcatta ttttatcaag aagtcttctc 3540
tgcctgtaag tgtccaaggt tatgacagta aacagttttt attaaaacat gagtcactat 3600
gggatgagaa aattgaaata aagctactgg gcctcctctc ataaaagaga cagttgttgg 3660
caaggtagca ataccagttt caaacttggt gacttgatcc actatgcctt aatggtttcc 3720
tccatttgag aaaataaagc tattcacatt gttaagaaaa atacttttta aagtttacca 3780
tcaagtcttt tttatattta tgtgtctgta ttctacccct ttttgcctta caagtgatat 3840
ttgcaggtat tataccattt ttctattctt ggtggcttct tcatagcagg taagcctctc 3900
cttctaaaaa cttctcaact gttttcattt aagggaaaga aaatgagtat tttgtccttt 3960
tgtgttccta cagacacttt cttaaaccag tttttggata aagaatacta tttccaaact 4020
catattacaa aaacaaaata aaataataaa aaaagaaagc atgatattta ctgttttgtt 4080
gtctgggttt gagaaatgaa atattgtttc caattattta taataaatca gtataaaatg 4140
ttttatgatt gttatgtgta ttatgtaata cgtacatgtt tatggcaatt taacatgtgt 4200
attcttttaa ttgtttcaga ataggataat taggtattcg aattttgtct ttaaaattca 4260
tgtggtttct atgcaaagtt cttcatatca tcacaacatt atttgattta aataaaattg 4320
aaagtaatat ttgtgcaa                                               4338

<210> 42
<211> 498
<212> PRT
<213> Homo sapiens

<400> 42
Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His
 1               5                  10                  15      
Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg
            20                  25                  30          
Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro
        35                  40                  45              
Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr
    50                  55                  60                  
Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser
65                  70                  75                  80  
Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp
                85                  90                  95      
Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met
            100                 105                 110         
Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu
        115                 120                 125             
Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys
    130                 135                 140                 
Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu
145                 150                 155                 160 
Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln
                165                 170                 175     
Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser
            180                 185                 190         
Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu
        195                 200                 205             
Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr
    210                 215                 220                 
Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala
225                 230                 235                 240 
Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp
                245                 250                 255     
Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu
            260                 265                 270         
Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp
        275                 280                 285             
Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile
    290                 295                 300                 
Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn
305                 310                 315                 320 
Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp
                325                 330                 335     
Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser
            340                 345                 350         
Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln
        355                 360                 365             
Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg
    370                 375                 380                 
Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn
385                 390                 395                 400 
Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser
                405                 410                 415     
Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn
            420                 425                 430         
Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp
        435                 440                 445             
Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala
    450                 455                 460                 
Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys
465                 470                 475                 480 
Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu
                485                 490                 495     
Asp Phe
        


<210> 43
<211> 6329
<212> DNA
<213> Homo sapiens

<400> 43
gattgggggc ggtggtctgg gtgtgattcc tgtgggggaa accagcccga ggtgccttgg 60
ctcaggcttg cctgcctgga gtccttgtcg tgtacccgtc tgtggcccta gagtcacctc 120
ctgctccttt tcactgggtt tctccccaga ccaagcccct ggatttgagc ttctgagcag 180
ccaactgatt tttttcatga gggaaagaat tttgctccta gatttatttc taatcctttt 240
ctccgtaact gaccttttct ctgtaagcta tttgtggctc tagtgggttt ttgtttgctt 300
gcttgttttt gttttatctt tgccctgaac gtccatcctg gcctcggctg cctccctccc 360
cgagttcttc actacacctc ctgtctcagc ctcccagaga gggtggcgag ggtgctgatg 420
cccagagaca ccatccggcg aatggacctc tcctgtcatg cggggcaggg cagggctgcc 480
ggcagagcca tgtcctgaac cctccctcct cccccctgct ctccttaagg gtctttccca 540
gatgtgaagg tccctcccag gctctactga ggtcagacca attcccagtg gcttgggtac 600
cctcgttcac tccagcacca gcccctgccc tccttcttcc cgggccaggc tgccaggtga 660
gccccgggcc aagggtggtt gccctgctga ggccgaaagg actcgagctt cccatctcct 720
cgcctccccc aggtctttca ccgtctggac tcatctctgg gtaactcatg gtgtgagtgg 780
ccacgtggct ggctcaggtg agtcctttta gaccccaggt gacccaccag ctagtccggg 840
gcccattgtt gtgcccacta ggatgtcccc catggtgtcc tccctgcgct ttaaagttct 900
ccttcgtgtg ctgttcttca tggcccctgt tcccccacag gtgtttggac agtgaacgcc 960
aggtcccctc ctccccaccc ccggcctctc aaacacgccc agccccacga tggcagcaga 1020
gacactcaac tttgggcctg agtggctcag ggccctgtcc gggggcggca gcgtggcctc 1080
cccacccccg tcccctgcca tgcccaaata caagctggct gactaccgtt atgggcgaga 1140
ggaaatgctg gctctctacg tcaaggagaa caaggtcccg gaagagctgc aggacaagga 1200
gttcgccgcg gtgctgcagg acgagccact gcagcccctg gctctggagc cgctgactga 1260
ggaggaacag agaaacttct ccctgtcagt gaacagcgtg gctgtgctga ggctgatggg 1320
gaaaggggct ggcccccccc tggctggcac ctcccgaggc aggggcagca cgcggagccg 1380
aggccgcggc cgtggtgaca gctgctttta ccaaagaagc atcgaagaag gcgatggggc 1440
ctttggacga agcccccggg aaatccagcg cagccagagc tgggatgaca gaggcgagag 1500
gcggtttgag aagtcagcaa ggcgggatgg agcacgatgt ggctttgagg agggaggggc 1560
tggcccaagg aaggagcacg cccgctcaga cagcgagaac tggcgctccc tacgggagga 1620
acaggaggag gaggaggagg gcagctggag gctcggagca gggccccggc gagacggcga 1680
ccgctggcgc tccgccagcc ctgatggtgg tccccgctct gctggctggc gggaacatgg 1740
ggaacggcgg cgcaagtttg aatttgattt gcgaggggat cgaggagggt gtggtgaaga 1800
ggaggggcgg ggagggggag gcagctctca cctgcggcgg tgccgagcgc ctgaaggctt 1860
tgaggaggac aaggatgggc tcccagagtg gtgcctggac gatgaggatg aagaaatggg 1920
cacctttgat gcctctgggg ccttcttgcc tctcaagaag ggccccaagg agcccattcc 1980
tgaggagcag gagctggact tccaagggtt ggaggaggag gaggaacctt ccgaagggct 2040
agaggaggaa gggcctgagg caggtgggaa agagctgacc ccactgcctc ctcaggagga 2100
gaagtccagc tccccatccc cactgcccac cctgggccca ctctggggga caaacgggga 2160
tggggacgaa actgcagaga aagagccccc agcggccgaa gatgatattc gggggatcca 2220
gctgagtccc ggggtgggct cctctgctgg cccacccgga gatctggagg atgatgaagg 2280
cttgaagcac ctgcagcagg aggcggagaa gctggtggcc tccctgcagg acagctcctt 2340
ggaggaggag cagttcacgg ctgccatgca gacccagggc ctgcgccact ctgcagccgc 2400
cactgccctc ccgctcagcc atggggctgc ccggaagtgg ttctacaagg acccacaggg 2460
cgagatccaa ggccccttca cgacacagga gatggcagag tggttccagg ccggctactt 2520
ttccatgtca ctgctggtga agcggggctg cgatgagggc ttccagccgc tgggcgaggt 2580
gatcaagatg tggggccgcg tgccctttgc cccagggccc tcacctcccc cactgctggg 2640
aaacatggac caggagcggc tgaagaagca acaggagctg gccgcggcgg ccttgtacca 2700
gcagctgcag caccagcagt ttctccagct ggtcagcagc cgccagctcc cacagtgcgc 2760
gctccgagaa aaggcagctc tgggggacct gacaccgcca ccaccgccgc cgccacagca 2820
gcagcagcag cagctcacgg cattcctgca gcagctccag gcgctcaaac cccccagagg 2880
cggggaccag aacctgctcc cgacgatgag ccggtccttg tcggtgccag attcgggccg 2940
cctctgggac gtacatacct cagcctcatc acagtcaggt ggtgaggcca gtctttggga 3000
cataccaatt aactcttcga ctcagggtcc aattctagaa caactccagc tgcaacataa 3060
attccaggag cgcagagaag tggagctcag ggcgaagcgg gaggaagagg aacgcaagcg 3120
tcgagaggag aagcgccgcc agcagcagca ggaggagcag aagcggcggc aggaggagga 3180
agagctgttt cggcgcaagc acgtgcggca gcaggagcta ttgctgaagt tgctacagca 3240
gcagcaggcg gtccctgtgc cccccgcacc cagctccccg cccccactct gggctggcct 3300
ggccaagcag gggctgtcca tgaagacgct cctggagttg cagctggagg gcgagcggca 3360
gctgcacaaa cagcccccac ctcgggagcc agctcgggcc caggccccca accaccgagt 3420
gcagcttggg ggcctgggca ctgcccccct gaaccagtgg gtgtctgagg ctgggccact 3480
gtggggcggg ccagacaaga gtgggggcgg cagcagcggc ctggggctct gggaggacac 3540
ccccaagagc ggcgggagcc tggtccgtgg cctcggcctg aagaacagcc ggagcagccc 3600
atctctcagt gactcataca gccacctatc gggtcggccc attcgcaaaa agacggagga 3660
agaagagaag ctgctgaagc tgctgcaggg cattcccagg ccccaggacg gcttcaccca 3720
gtggtgcgag cagatgctgc acacgctgag cgccacgggc agcctggacg tgcccatggc 3780
tgtagcgatc ctcaaggagg tggaatcccc ctatgatgtc cacgattata tccgttcctg 3840
cctgggggac acgctggaag ccaaagaatt tgccaaacaa ttcctggagc ggagggccaa 3900
gcagaaagcc agccagcagc ggcagcagca gcaggaggca tggctgagca gcgcctcgct 3960
gcagacggcc ttccaggcca accacagcac caaactcggc cccggggagg gcagcaaggc 4020
caagaggcgg gcactgatgc tgcactcaga ccccagcatc ctggggtact ccctgcacgg 4080
atcttctggt gagatcgaga gcgtggatga ctactgacca gcccggaccc ccagcccctg 4140
ggctgtaggc cagggcagcc acagcggcgt ggaccgaggg tcccagcctg caggctcccc 4200
gcagagagca caggaagagg caggggcggg gtccccagca cttgttacaa acacacgatg 4260
caccttaact cacccaccac gaggcacttt acagactggg ggagggggtt tttcttttta 4320
tttttttttt taattttaaa cgactgaaga aaacattagg agaggcaaaa atattgttaa 4380
aaactagact ctaaacaccc cttcctgctg tgaggatagt gggtgtgaca atggaaggtc 4440
cacagaggtt tttgtttttt ggtttttttt ttttttttaa gaaaaaaaga tgaaaaatga 4500
aaaaaaaaat ggttaggagg ctgaaagaaa aaacacactg ttattttggg gcagtgggga 4560
cacaggcccc gtggacctgt cctgcctggc ccccaaggcc atacttaccc cccagaaggc 4620
gggccatggg gtaactggaa gctgggggcc agcagtttgc acaggaggcc tgtctgagcc 4680
ccacccgcca gacctgttgt gagcagctcc tgtcactgag gctggctgag gtgtccgggg 4740
tggggccaaa gtagcccctt ggcttcgctg ctttggggga cagttgcaca aattggacga 4800
gtggccccag ctctctggct gccatcttgt gctggccgag tagacgggag gggccaagcc 4860
gtgccaacct ctctggctgg cagggtgggg cagcaggact ctggttctgg tgaggggcgt 4920
ctcccactgc tgccattttg ggggacaccc tgggtttgaa cctgaaagcc ccagctctct 4980
gccttgccac gtgaatgtat tctttgggcc acaagccccc gcctcacccc tgcctgagct 5040
gcctcacccc tgtgagcggc gggggtggat gattgctcca gaggctgcag agagaaggct 5100
gagctgtttc tccagtgaag ggggcaggag gaggggcctc aaaggcaagg agtgggtggc 5160
tttgggctta gggttgcagt agaggggctg ccgcccgggg ccccaacctg tagccagctc 5220
gtaagatgtg gaccacccag ctctgcacct gacccttccg ctgaccaaat gggagaggag 5280
caggtggcct tccgggtctg atatgatgcg ctttttaccg ttgggtaagg ttggggtgaa 5340
gagaagtgtg cggctcctgg gtcagaggag gctgcccctt ctattgctca cccacttctt 5400
attcccggtc ccctacttgg gttcgtctcc gcccattttg ggttttgtaa cagttttgtc 5460
ttttgggttt ctcatccagc tcctcccatt gacctcattg ctcagagtgc agtattaggg 5520
caaggcttcg ccactgcctc cctccatgaa tgtatttctc cctcctgccc tggggacatg 5580
gggagtggcc cgtttctttc cccatctagt cccagaaaga tggtgtttgg ttttctgttg 5640
ttggattttt tttttttttt tttttttttt gcaccaaagt ggcaactagg tcagtgttgg 5700
gggatcaagc tggcctcggg gtggggggcc cccacctgcc tctccctggt tcccacagtg 5760
ttagcgtccc tgaaaagaca atattctctc taaagcaata aggggtgacg ggccgggggg 5820
agtgtttgct gctgctggcc cccagctccc cttccctctt gccaggtgtg ggggagactc 5880
ctgttgtgac tgaatgtaac ccccccaccc ctgccgcagc caatgcaggg gaagggggac 5940
actcttcctg tctcttctcc ccagctaaag agactttgga cttagggggc ccatgagcct 6000
ggagaggcct taaccctgtg aggaagtata gggggagccc tctcccaccc ccatcccctt 6060
ctgagagtgg tcaatgttta caagcccctg agcccccctg cccagggact cagaccctgt 6120
tgctgtcctt ccccggcccc ggtcttcctg ggccctcgct gctcccctgc ccttcctggg 6180
gttggggtgg gtgcaggggt caccgtgttc cctgtctgcc ttgtacccac agtctccccg 6240
ccccctctcc accctgtgtg acttccctct cttttacctg ctcctgtaaa tactcccttc 6300
tcccaataaa acttggtgtg tgttctccc                                   6329



<210> 44
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 44
Met Ala Ala Glu Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg Ala Leu
 1               5                  10                  15      
Ser Gly Gly Gly Ser Val Ala Ser Pro Pro Pro Ser Pro Ala Met Pro
            20                  25                  30          
Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met Leu Ala
        35                  40                  45              
Leu Tyr Val Lys Glu Asn Lys Val Pro Glu Glu Leu Gln Asp Lys Glu
    50                  55                  60                  
Phe Ala Ala Val Leu Gln Asp Glu Pro Leu Gln Pro Leu Ala Leu Glu
65                  70                  75                  80  
Pro Leu Thr Glu Glu Glu Gln Arg Asn Phe Ser Leu Ser Val Asn Ser
                85                  90                  95      
Val Ala Val Leu Arg Leu Met Gly Lys Gly Ala Gly Pro Pro Leu Ala
            100                 105                 110         
Gly Thr Ser Arg Gly Arg Gly Ser Thr Arg Ser Arg Gly Arg Gly Arg
        115                 120                 125             
Gly Asp Ser Cys Phe Tyr Gln Arg Ser Ile Glu Glu Gly Asp Gly Ala
    130                 135                 140                 
Phe Gly Arg Ser Pro Arg Glu Ile Gln Arg Ser Gln Ser Trp Asp Asp
145                 150                 155                 160 
Arg Gly Glu Arg Arg Phe Glu Lys Ser Ala Arg Arg Asp Gly Ala Arg
                165                 170                 175     
Cys Gly Phe Glu Glu Gly Gly Ala Gly Pro Arg Lys Glu His Ala Arg
            180                 185                 190         
Ser Asp Ser Glu Asn Trp Arg Ser Leu Arg Glu Glu Gln Glu Glu Glu
        195                 200                 205             
Glu Glu Gly Ser Trp Arg Leu Gly Ala Gly Pro Arg Arg Asp Gly Asp
    210                 215                 220                 
Arg Trp Arg Ser Ala Ser Pro Asp Gly Gly Pro Arg Ser Ala Gly Trp
225                 230                 235                 240 
Arg Glu His Gly Glu Arg Arg Arg Lys Phe Glu Phe Asp Leu Arg Gly
                245                 250                 255     
Asp Arg Gly Gly Cys Gly Glu Glu Glu Gly Arg Gly Gly Gly Gly Ser
            260                 265                 270         
Ser His Leu Arg Arg Cys Arg Ala Pro Glu Gly Phe Glu Glu Asp Lys
        275                 280                 285             
Asp Gly Leu Pro Glu Trp Cys Leu Asp Asp Glu Asp Glu Glu Met Gly
    290                 295                 300                 
Thr Phe Asp Ala Ser Gly Ala Phe Leu Pro Leu Lys Lys Gly Pro Lys
305                 310                 315                 320 
Glu Pro Ile Pro Glu Glu Gln Glu Leu Asp Phe Gln Gly Leu Glu Glu
                325                 330                 335     
Glu Glu Glu Pro Ser Glu Gly Leu Glu Glu Glu Gly Pro Glu Ala Gly
            340                 345                 350         
Gly Lys Glu Leu Thr Pro Leu Pro Pro Gln Glu Glu Lys Ser Ser Ser
        355                 360                 365             
Pro Ser Pro Leu Pro Thr Leu Gly Pro Leu Trp Gly Thr Asn Gly Asp
    370                 375                 380                 
Gly Asp Glu Thr Ala Glu Lys Glu Pro Pro Ala Ala Glu Asp Asp Ile
385                 390                 395                 400 
Arg Gly Ile Gln Leu Ser Pro Gly Val Gly Ser Ser Ala Gly Pro Pro
                405                 410                 415     
Gly Asp Leu Glu Asp Asp Glu Gly Leu Lys His Leu Gln Gln Glu Ala
            420                 425                 430         
Glu Lys Leu Val Ala Ser Leu Gln Asp Ser Ser Leu Glu Glu Glu Gln
        435                 440                 445             
Phe Thr Ala Ala Met Gln Thr Gln Gly Leu Arg His Ser Ala Ala Ala
    450                 455                 460                 
Thr Ala Leu Pro Leu Ser His Gly Ala Ala Arg Lys Trp Phe Tyr Lys
465                 470                 475                 480 
Asp Pro Gln Gly Glu Ile Gln Gly Pro Phe Thr Thr Gln Glu Met Ala
                485                 490                 495     
Glu Trp Phe Gln Ala Gly Tyr Phe Ser Met Ser Leu Leu Val Lys Arg
            500                 505                 510         
Gly Cys Asp Glu Gly Phe Gln Pro Leu Gly Glu Val Ile Lys Met Trp
        515                 520                 525             
Gly Arg Val Pro Phe Ala Pro Gly Pro Ser Pro Pro Pro Leu Leu Gly
    530                 535                 540                 
Asn Met Asp Gln Glu Arg Leu Lys Lys Gln Gln Glu Leu Ala Ala Ala
545                 550                 555                 560 
Ala Leu Tyr Gln Gln Leu Gln His Gln Gln Phe Leu Gln Leu Val Ser
                565                 570                 575     
Ser Arg Gln Leu Pro Gln Cys Ala Leu Arg Glu Lys Ala Ala Leu Gly
            580                 585                 590         
Asp Leu Thr Pro Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln
        595                 600                 605             
Leu Thr Ala Phe Leu Gln Gln Leu Gln Ala Leu Lys Pro Pro Arg Gly
    610                 615                 620                 
Gly Asp Gln Asn Leu Leu Pro Thr Met Ser Arg Ser Leu Ser Val Pro
625                 630                 635                 640 
Asp Ser Gly Arg Leu Trp Asp Val His Thr Ser Ala Ser Ser Gln Ser
                645                 650                 655     
Gly Gly Glu Ala Ser Leu Trp Asp Ile Pro Ile Asn Ser Ser Thr Gln
            660                 665                 670         
Gly Pro Ile Leu Glu Gln Leu Gln Leu Gln His Lys Phe Gln Glu Arg
        675                 680                 685             
Arg Glu Val Glu Leu Arg Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg
    690                 695                 700                 
Arg Glu Glu Lys Arg Arg Gln Gln Gln Gln Glu Glu Gln Lys Arg Arg
705                 710                 715                 720 
Gln Glu Glu Glu Glu Leu Phe Arg Arg Lys His Val Arg Gln Gln Glu
                725                 730                 735     
Leu Leu Leu Lys Leu Leu Gln Gln Gln Gln Ala Val Pro Val Pro Pro
            740                 745                 750         
Ala Pro Ser Ser Pro Pro Pro Leu Trp Ala Gly Leu Ala Lys Gln Gly
        755                 760                 765             
Leu Ser Met Lys Thr Leu Leu Glu Leu Gln Leu Glu Gly Glu Arg Gln
    770                 775                 780                 
Leu His Lys Gln Pro Pro Pro Arg Glu Pro Ala Arg Ala Gln Ala Pro
785                 790                 795                 800 
Asn His Arg Val Gln Leu Gly Gly Leu Gly Thr Ala Pro Leu Asn Gln
                805                 810                 815     
Trp Val Ser Glu Ala Gly Pro Leu Trp Gly Gly Pro Asp Lys Ser Gly
            820                 825                 830         
Gly Gly Ser Ser Gly Leu Gly Leu Trp Glu Asp Thr Pro Lys Ser Gly
        835                 840                 845             
Gly Ser Leu Val Arg Gly Leu Gly Leu Lys Asn Ser Arg Ser Ser Pro
    850                 855                 860                 
Ser Leu Ser Asp Ser Tyr Ser His Leu Ser Gly Arg Pro Ile Arg Lys
865                 870                 875                 880 
Lys Thr Glu Glu Glu Glu Lys Leu Leu Lys Leu Leu Gln Gly Ile Pro
                885                 890                 895     
Arg Pro Gln Asp Gly Phe Thr Gln Trp Cys Glu Gln Met Leu His Thr
            900                 905                 910         
Leu Ser Ala Thr Gly Ser Leu Asp Val Pro Met Ala Val Ala Ile Leu
        915                 920                 925             
Lys Glu Val Glu Ser Pro Tyr Asp Val His Asp Tyr Ile Arg Ser Cys
    930                 935                 940                 
Leu Gly Asp Thr Leu Glu Ala Lys Glu Phe Ala Lys Gln Phe Leu Glu
945                 950                 955                 960 
Arg Arg Ala Lys Gln Lys Ala Ser Gln Gln Arg Gln Gln Gln Gln Glu
                965                 970                 975     
Ala Trp Leu Ser Ser Ala Ser Leu Gln Thr Ala Phe Gln Ala Asn His
            980                 985                 990         
Ser Thr Lys Leu Gly Pro Gly Glu Gly Ser Lys Ala Lys Arg Arg Ala
        995                 1000                1005            
Leu Met Leu His Ser Asp Pro Ser Ile Leu Gly Tyr Ser Leu His Gly
    1010                1015                1020                
Ser Ser Gly Glu Ile Glu Ser Val Asp Asp Tyr
1025                1030                1035


<210> 45
<211> 2258
<212> DNA
<213> Homo sapiens

<400> 45
gtccgcagcc ccgcctgttc ctcccgaggg ccgcgcgctc tcgccggccc gccccgaacc 60
gccccgcgct gggaatttgc ggcggcctcc gccggggcag ccgagctgaa ccggtctctt 120
cctcggaaag gcagggccga ggggcctgcg gggcagccat ggaggcgacg cggaggcggc 180
agcacctggg agcgacgggc ggcccaggcg cgcagctggg cgcctccttc ctgcaggcca 240
ggcatggctc tgtgagcgct gatgaggctg cccgcacggc tcccttccac ctcgacctct 300
ggttctactt cacactgcag aactgggttc tggactttgg gcgtcccatt gccatgctgg 360
tattccctct cgagtggttt ccactcaaca agcccagtgt tggggactac ttccacatgg 420
cctacaacgt catcacgccc tttctcttgc tcaagctcat cgagcggtcc ccccgcaccc 480
tgccacgctc catcacgtac gtgagcatca tcatcttcat catgggtgcc agcatccacc 540
tggtgggtga ctctgtcaac caccgcctgc tcttcagtgg ctaccagcac cacctgtctg 600
tccgtgagaa ccccatcatc aagaatctca agccggagac gctgatcgac tcctttgagc 660
tgctctacta ttatgatgag tacctgggtc actgcatgtg gtacatcccc ttcttcctca 720
tcctcttcat gtacttcagc ggctgcttta ctgcctctaa agctgagagc ttgattccag 780
ggcctgccct gctcctggtg gcacccagtg gcctgtacta ctggtacctg gtcaccgagg 840
gccagatctt catcctcttc atcttcacct tcttcgccat gctggccctc gtcctgcacc 900
agaagcgcaa gcgcctcttc ctggacagca acggcctctt cctcttctcc tccttcgcac 960
tgaccctctt gcttgtggcg ctctgggtcg cctggctgtg gaatgaccct gttctcagga 1020
agaagtaccc gggtgtcatc tacgtccctg agccctgggc tttctacacc cttcacgtca 1080
gcagtcggca ctgagtccct ggcaccaggc tctggcgctc tgctgggtgg gagggtgggc 1140
catggagggc atctgaatac aggagtaggg ggggtgtggg tgtgtaacca gagaccgaga 1200
gcatgagtgg ggtgtgcctc gtgtgcgtgg attcgtgtgt gtgtgtgtgt gtgtcttgta 1260
tatgtgtgcg cagagtgcat cattttcaga ctctactatt tccgtcaagt ttctgtttga 1320
tttggatcat ctcaggatcg gattctgttt tagagtgttt ctgggccagg atccgggccc 1380
ctgccctcct ctgcacctga ccacactccc tactcagggc tagtctgttc ttcccggaca 1440
tcttctggta gccgtgcagg agagggctgg gtggggcaga ggccaggagg ggacctggtg 1500
tgtcacctgc ccaccacctg gctcatccct caggcccacc ctgaccctac attacatagg 1560
ttacgtcagc ctactgtggc tgttgagcaa agcatttctc ctttctgggc ctcatttgca 1620
ctagatgggc ctgtggtccc aaagtaggtc agtaggttgg ggttgctgac accccttggg 1680
tgcagctttg ggacagatga gtggctctgt cctgtcactg ccctctccct gcctgggggc 1740
tatgtgcact ccagacccct gcccaggctc aggcccatga ggtatggaga caccctggcc 1800
cccaggagct ggaggcaccg cccactcccc tggcattcca gctttgcagg tgaccctcct 1860
ctacccaaag ctctgtcccc ctgctcccac tccagaagaa ctgcggcacg cgcttcgggc 1920
agcctagcca caggctttga gcgcctgcat tcctgggggc tggagggtgg ggtgccaaag 1980
gccctgagca aaagccagag ctcctctcat caaagccttt acaaggtgct gggcccagag 2040
gctttgcctt gacagagtgg cccagggttt caagggagga ggaacctccc cctacctagg 2100
acccttcctg tggggggtct acagagtcag ggacagaagg gaagggaccc acaggaagtc 2160
acagtggtgc ccagggatgt gtcagccccc agccacgggg acgcgggatt caagaatgaa 2220
gtaaatacag tcacagcccc aaaaaaaaaa aaaaaaaa                         2258

<210> 46
<211> 311
<212> PRT
<213> Homo sapiens

<400> 46
Met Glu Ala Thr Arg Arg Arg Gln His Leu Gly Ala Thr Gly Gly Pro
 1               5                  10                  15      
Gly Ala Gln Leu Gly Ala Ser Phe Leu Gln Ala Arg His Gly Ser Val
            20                  25                  30          
Ser Ala Asp Glu Ala Ala Arg Thr Ala Pro Phe His Leu Asp Leu Trp
        35                  40                  45              
Phe Tyr Phe Thr Leu Gln Asn Trp Val Leu Asp Phe Gly Arg Pro Ile
    50                  55                  60                  
Ala Met Leu Val Phe Pro Leu Glu Trp Phe Pro Leu Asn Lys Pro Ser
65                  70                  75                  80  
Val Gly Asp Tyr Phe His Met Ala Tyr Asn Val Ile Thr Pro Phe Leu
                85                  90                  95      
Leu Leu Lys Leu Ile Glu Arg Ser Pro Arg Thr Leu Pro Arg Ser Ile
            100                 105                 110         
Thr Tyr Val Ser Ile Ile Ile Phe Ile Met Gly Ala Ser Ile His Leu
        115                 120                 125             
Val Gly Asp Ser Val Asn His Arg Leu Leu Phe Ser Gly Tyr Gln His
    130                 135                 140                 
His Leu Ser Val Arg Glu Asn Pro Ile Ile Lys Asn Leu Lys Pro Glu
145                 150                 155                 160 
Thr Leu Ile Asp Ser Phe Glu Leu Leu Tyr Tyr Tyr Asp Glu Tyr Leu
                165                 170                 175     
Gly His Cys Met Trp Tyr Ile Pro Phe Phe Leu Ile Leu Phe Met Tyr
            180                 185                 190         
Phe Ser Gly Cys Phe Thr Ala Ser Lys Ala Glu Ser Leu Ile Pro Gly
        195                 200                 205             
Pro Ala Leu Leu Leu Val Ala Pro Ser Gly Leu Tyr Tyr Trp Tyr Leu
    210                 215                 220                 
Val Thr Glu Gly Gln Ile Phe Ile Leu Phe Ile Phe Thr Phe Phe Ala
225                 230                 235                 240 
Met Leu Ala Leu Val Leu His Gln Lys Arg Lys Arg Leu Phe Leu Asp
                245                 250                 255     
Ser Asn Gly Leu Phe Leu Phe Ser Ser Phe Ala Leu Thr Leu Leu Leu
            260                 265                 270         
Val Ala Leu Trp Val Ala Trp Leu Trp Asn Asp Pro Val Leu Arg Lys
        275                 280                 285             
Lys Tyr Pro Gly Val Ile Tyr Val Pro Glu Pro Trp Ala Phe Tyr Thr
    290                 295                 300                 
Leu His Val Ser Ser Arg His
305                 310     


<210> 47
<211> 4293
<212> DNA
<213> Homo sapiens

<400> 47
gtttctcata gttggcgtct tctaaaggaa aaacactaaa atgaggaact cagcggaccg 60
ggagcgacgc agcttgaggg aagcatccct agctgttggc gcagaggggc gaggctgaag 120
ccgagtggcc cgaggtgtct gaggggctgg ggcaaaggtg aaagagtttc agaacaagct 180
tcctggaacc catgacccat gaagtcttgt cgacatttat accgtctgag ggtagcagct 240
cgaaagtaga agaagtggag tgttgccagg gacggcagta tctctttgtg tgaccctggc 300
ggcttatggg acgttggctt cagacctttg tgatacacca tgctgcgtgg gacgatgacg 360
gcgtggagag gaatgaggcc tgaggtcaca ctggcttgcc tcctcctagc cacagcaggc 420
tgctttgctg acttgaacga ggtccctcag gtcaccgtcc agcctgcgtc caccgtccag 480
aagcccggag gcactgtgat cttgggctgc gtggtggaac ctccaaggat gaatgtaacc 540
tggcgcctga atggaaagga gctgaatggc tcggatgatg ctctgggtgt cctcatcacc 600
cacgggaccc tcgtcatcac tgcccttaac aaccacactg tgggacggta ccagtgtgtg 660
gcccggatgc ctgcgggggc tgtggccagc gtgccagcca ctgtgacact agccaatctc 720
caggacttca agttagatgt gcagcacgtg attgaagtgg atgagggaaa cacagcagtc 780
attgcctgcc acctgcctga gagccacccc aaagcccagg tccggtacag cgtcaaacaa 840
gagtggctgg aggcctccag aggtaactac ctgatcatgc cctcagggaa cctccagatt 900
gtgaatgcca gccaggagga cgagggcatg tacaagtgtg cagcctacaa cccagtgacc 960
caggaagtga aaacctccgg ctccagcgac aggctacgtg tgcgccgctc caccgctgag 1020
gctgcccgca tcatctaccc cccagaggcc caaaccatca tcgtcaccaa aggccagagt 1080
ctcattctgg agtgtgtggc cagtggaatc ccacccccac gggtcacctg ggccaaggat 1140
gggtccagtg tcaccggcta caacaagacg cgcttcctgc tgagcaacct cctcatcgac 1200
accaccagcg aggaggactc aggcacctac cgctgcatgg ccgacaatgg ggttgggcag 1260
cccggggcag cggtcatcct ctacaatgtc caggtgtttg aaccccctga ggtcaccatg 1320
gagctatccc agctggtcat cccctggggc cagagtgcca agcttacctg tgaggtgcgt 1380
gggaaccccc cgccctccgt gctgtggctg aggaatgctg tgcccctcat ctccagccag 1440
cgcctccggc tctcccgcag ggccctgcgc gtgctcagca tggggcctga ggacgaaggc 1500
gtctaccagt gcatggccga gaacgaggtt gggagcgccc atgccgtagt ccagctgcgg 1560
acctccaggc caagcataac cccaaggcta tggcaggatg ctgagctggc tactggcaca 1620
cctcctgtat caccctccaa actcggcaac cctgagcaga tgctgagggg gcaaccggcg 1680
ctccccagac ccccaacgtc agtggggcct gcttccccgc agtgtccagg agagaagggg 1740
cagggggctc ccgccgaggc tcccatcatc ctcagctcgc cccgcacctc caagacagac 1800
tcatatgaac tggtgtggcg gcctcggcat gagggcagtg gccgggcgcc aatcctctac 1860
tatgtggtga aacaccgcaa ggtcacaaat tcctctgacg attggaccat ctctggcatt 1920
ccagccaacc agcaccgcct gaccctcacc agacttgacc ccgggagctt gtatgaagtg 1980
gagatggcag cttacaactg tgcgggagag ggccagacag ccatggtcac cttccgaact 2040
ggacggcggc ccaaacccga gatcatggcc agcaaagagc agcagatcca gagagacgac 2100
cctggagcca gtccccagag cagcagccag ccagaccacg gccgcctctc ccccccagaa 2160
gctcccgaca ggcccaccat ctccacggcc tccgagacct cagtgtacgt gacctggatt 2220
ccccgtggga atggtgggtt cccaatccag tccttccgtg tggagtacaa gaagctaaag 2280
aaagtgggag actggattct ggccaccagc gccatccccc catcgcggct gtccgtggag 2340
atcacgggcc tagagaaagg cacctcctac aagtttcgag tccgggctct gaacatgctg 2400
ggggagagcg agcccagcgc cccctctcgg ccctacgtgg tgtcgggcta cagcggtcgc 2460
gtgtacgaga ggcccgtggc aggtccttat atcaccttca cggatgcggt caatgagacc 2520
accatcatgc tcaagtggat gtacatccca gcaagtaaca acaacacccc aatccatggc 2580
ttttatatct attatcgacc cacagacagt gacaatgata gtgactacaa gaaggatatg 2640
gtggaagggg acaagtactg gcactccatc agccacctgc agccagagac ctcctacgac 2700
attaagatgc agtgcttcaa tgaaggaggg gagagcgagt tcagcaacgt gatgatctgt 2760
gagaccaaag ctcggaagtc ttctggccag cctggtcgac tgccaccccc aactctggcc 2820
ccaccacagc cgccccttcc tgaaaccata gagcggccgg tgggcactgg ggccatggtg 2880
gctcgctcca gcgacctgcc ctatctgatt gtcggggtcg tcctgggctc catcgttctc 2940
atcatcgtca ccttcatccc cttctgcttg tggagggcct ggtctaagca aaaacataca 3000
acagacctgg gttttcctcg aagtgccctt ccaccctcct gcccgtatac tatggtgcca 3060
ttgggaggac tcccaggcca ccaggccagt ggacagccct acctcagtgg catcagtgga 3120
cgggcctgtg ctaatgggat ccacatgaat aggggctgcc cctcggctgc agtgggctac 3180
ccgggcatga agccccagca gcactgccca ggcgagcttc agcagcagag tgacaccagc 3240
agcctgctga ggcagaccca tcttggcaat ggatatgacc cccaaagtca ccagatcacg 3300
aggggtccca agtctagccc ggacgagggc tctttcttat acacactgcc cgacgactcc 3360
actcaccagc tgctgcagcc ccatcacgac tgctgccaac gccaggagca gcctgctgct 3420
gtgggccagt caggggtgag gagagccccc gacagtcctg tcctggaagc agtgtgggac 3480
cctccatttc actcagggcc cccatgctgc ttgggccttg tgccagttga agaggtggac 3540
agtcctgact cctgccaagt gagtggagga gactggtgtc cccagcaccc cgtaggggcc 3600
tacgtaggac aggaacctgg aatgcagctc tccccggggc cactggtgcg tgtgtctttt 3660
gaaacaccac ctctcacaat ttaggcagaa gctgatatcc cagaaagact atatattgtt 3720
ttttttttaa aaaaaaaaag aagaaaaaag agacagagaa aattggtatt tatttttcta 3780
ttatagccat atttatatat ttatgcactt gtaaataaat gtatatgttt tataattctg 3840
gagagacata aggagtccta cccgttgagg ttggagaggg aaaataaaga agctgccacc 3900
taacaggagt cacccaggaa agcaccgcac aggctggcgc gggacagact cctaacctgg 3960
ggcctctgca gtggcaggcg aggctgcagg aggcccacag ataagctggc aagaggaagg 4020
atcccaggca catggttcat cacgagcatg agggaacagc aaggggcacg gtatcacagc 4080
ctggagacac ccacacagat ggctggatcc ggtgctacgg gaaacatttt cctaagatgc 4140
ccatgagaac agaccaagat gtgtacagca ctatgagcat taaaaaacct tccagaatca 4200
ataatccgtg gcaacatatc tctgtaaaaa caaacactgt aacttctaaa taaatgttta 4260
gtcttccctg taaccttcaa aaaaaaaaaa aaa                              4293

<210> 48
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 48
Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val
 1               5                  10                  15      
Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu
            20                  25                  30          
Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys
        35                  40                  45              
Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met
    50                  55                  60                  
Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp
65                  70                  75                  80  
Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu
                85                  90                  95      
Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala
            100                 105                 110         
Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln
        115                 120                 125             
Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn
    130                 135                 140                 
Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln
145                 150                 155                 160 
Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn
                165                 170                 175     
Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln
            180                 185                 190         
Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln
        195                 200                 205             
Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser
    210                 215                 220                 
Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile
225                 230                 235                 240 
Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly
                245                 250                 255     
Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr
            260                 265                 270         
Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr
        275                 280                 285             
Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly
    290                 295                 300                 
Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe
305                 310                 315                 320 
Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp
                325                 330                 335     
Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro
            340                 345                 350         
Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg
        355                 360                 365             
Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu
    370                 375                 380                 
Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala
385                 390                 395                 400 
His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg
                405                 410                 415     
Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro
            420                 425                 430         
Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu
        435                 440                 445             
Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly
    450                 455                 460                 
Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser
465                 470                 475                 480 
Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg
                485                 490                 495     
His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His
            500                 505                 510         
Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro
        515                 520                 525             
Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu
    530                 535                 540                 
Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr
545                 550                 555                 560 
Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met
                565                 570                 575     
Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro
            580                 585                 590         
Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala
        595                 600                 605             
Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val
    610                 615                 620                 
Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg
625                 630                 635                 640 
Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr
                645                 650                 655     
Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu
            660                 665                 670         
Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly
        675                 680                 685             
Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr
    690                 695                 700                 
Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe
705                 710                 715                 720 
Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile
                725                 730                 735     
Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr
            740                 745                 750         
Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val
        755                 760                 765             
Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr
    770                 775                 780                 
Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu
785                 790                 795                 800 
Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly
                805                 810                 815     
Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro
            820                 825                 830         
Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala
        835                 840                 845             
Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser
    850                 855                 860                 
Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala
865                 870                 875                 880 
Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala
                885                 890                 895     
Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro
            900                 905                 910         
Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg
        915                 920                 925             
Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala
    930                 935                 940                 
Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu
945                 950                 955                 960 
Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly
                965                 970                 975     
Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser
            980                 985                 990         
Ser Pro Asp Glu Gly Ser Phe Leu Tyr Thr Leu Pro Asp Asp Ser Thr
        995                 1000                1005            
His Gln Leu Leu Gln Pro His His Asp Cys Cys Gln Arg Gln Glu Gln
    1010                1015                1020                
Pro Ala Ala Val Gly Gln Ser Gly Val Arg Arg Ala Pro Asp Ser Pro
1025                1030                1035               1040 
Val Leu Glu Ala Val Trp Asp Pro Pro Phe His Ser Gly Pro Pro Cys
                1045                1050                1055    
Cys Leu Gly Leu Val Pro Val Glu Glu Val Asp Ser Pro Asp Ser Cys
            1060                1065                1070        
Gln Val Ser Gly Gly Asp Trp Cys Pro Gln His Pro Val Gly Ala Tyr
        1075                1080                1085            
Val Gly Gln Glu Pro Gly Met Gln Leu Ser Pro Gly Pro Leu Val Arg
    1090                1095                1100                
Val Ser Phe Glu Thr Pro Pro Leu Thr Ile
1105                1110                


<210> 49
<211> 1627
<212> DNA
<213> Homo sapiens

<400> 49
attcctagtg actccaagcg cttaaaaggg gcccgggagg atgaacccca cagatctgaa 60
cctgatttgt gtgtgcaccg cgtctccagc gatcccggat ccactgcgct gccaggggcc 120
tgggggtggg tctcttgctg tctctgcgac gacatcctta cgtttcggca ctctaatgct 180
gggtttgtgc gtgtgtgtct gcttagcggt ctagcgggct gttaggctcc ctcgccccca 240
gctccttggc tcgctcagct cctccaccgc agcccagcag tgagacgcgc gcgcagccag 300
ctccccacga gatggaacag accgaagtgc tgaagccacg gaccctggct gatctgatcc 360
gcatcctgca ccagctcttt gccggcgatg aggtcaatgt agaggaggtg caggccatca 420
tggaagccta cgagagcgac cccaccgagt gggcaatgta cgccaagttc gaccagtaca 480
ggtatacccg aaatcttgtg gatcaaggaa atggaaaatt taatctgatg attctctgtt 540
ggggtgaagg acatggcagc agtattcatg atcataccaa ctcccactgc tttctgaaga 600
tgctacaggg aaatctaaag gagacattat ttgcctggcc tgacaaaaaa tccaatgaga 660
tggtcaagaa gtctgaaaga gtcttgaggg aaaaccagtg tgcctacatc aatgattcca 720
ttggcttaca tcgagtagag aacatcagcc atacggaacc tgctgtgagc cttcacttgt 780
acagtccacc ttttgataca tgccatgcct ttgatcaaag aacaggacat aaaaacaaag 840
tcacaatgac attccatagt aaatttggaa tcagaactcc aaatgcaact tcgggctcgc 900
tggagaacaa ctaaggggca ccaaaccctc tgaggtttta ctttaaggtt cgctgtatgt 960
ttgccttgga caaaaaggct acctaccacg tgctatccag taatatactt aaataagcca 1020
atacttagat ctactgtaag gcagatgcta attataaggc attaagtaag caaatagtgc 1080
cctcagctac tgcagaagaa aagtcccact gaggaaaaga aagtcttgtg atttttaaag 1140
gcaagttttc aagtgctctc atagttctat cctctaattc cattaaatcc atactaggag 1200
cgtcagtgag ggttttcata gcttttggaa atactttggt ctctgaactg taattagcaa 1260
gaagtaaaaa cagaaacgtc aaacgtcaaa tgtttgcttt gttacctgga ggactaaatg 1320
tagatgtctt tagtatactt tgtatgttct taatattgga agataatttt gtgaatctgt 1380
agattttatt ttttcagtct taccttacaa atttcttttc tatgaataat agaggaactt 1440
acggcactct gccatttgtt aatgaaagga agtgcagagg atttagaaaa gtacatgatc 1500
cccagaccac aacaaaccaa aacataaact catgtctgtg tcccatggtc atagtcaaag 1560
attttgtact gctaaaatta ccaaataatt taaataaagt ggatttgaac acaaaaaaaa 1620
aaaaaaa                                                           1627

<210> 50
<211> 200
<212> PRT
<213> Homo sapiens

<400> 50
Met Glu Gln Thr Glu Val Leu Lys Pro Arg Thr Leu Ala Asp Leu Ile
 1               5                  10                  15      
Arg Ile Leu His Gln Leu Phe Ala Gly Asp Glu Val Asn Val Glu Glu
            20                  25                  30          
Val Gln Ala Ile Met Glu Ala Tyr Glu Ser Asp Pro Thr Glu Trp Ala
        35                  40                  45              
Met Tyr Ala Lys Phe Asp Gln Tyr Arg Tyr Thr Arg Asn Leu Val Asp
    50                  55                  60                  
Gln Gly Asn Gly Lys Phe Asn Leu Met Ile Leu Cys Trp Gly Glu Gly
65                  70                  75                  80  
His Gly Ser Ser Ile His Asp His Thr Asn Ser His Cys Phe Leu Lys
                85                  90                  95      
Met Leu Gln Gly Asn Leu Lys Glu Thr Leu Phe Ala Trp Pro Asp Lys
            100                 105                 110         
Lys Ser Asn Glu Met Val Lys Lys Ser Glu Arg Val Leu Arg Glu Asn
        115                 120                 125             
Gln Cys Ala Tyr Ile Asn Asp Ser Ile Gly Leu His Arg Val Glu Asn
    130                 135                 140                 
Ile Ser His Thr Glu Pro Ala Val Ser Leu His Leu Tyr Ser Pro Pro
145                 150                 155                 160 
Phe Asp Thr Cys His Ala Phe Asp Gln Arg Thr Gly His Lys Asn Lys
                165                 170                 175     
Val Thr Met Thr Phe His Ser Lys Phe Gly Ile Arg Thr Pro Asn Ala
            180                 185                 190         
Thr Ser Gly Ser Leu Glu Asn Asn
        195                 200 


<210> 51
<211> 2575
<212> DNA
<213> Homo sapiens

<400> 51
ggaggaggaa gcaagcgagg gggctggttc ctgagcttcg caattcctgt gtcgccttct 60
gggctcccag cctgccgggt cgcatgatcc ctccggccgg agctggtttt tttgccagcc 120
accgcgaggc cggctgagtt accggcatcc ccgcagccac ctcctctccc gacctgtgat 180
acaaaagatc ttccgggggc tgcacctgcc tgcctttgcc taaggcggat ttgaatctct 240
ttctctccct tcagaatctt atcttggctt tggatcttag aagagaatca ctaaccagag 300
acgagactca gtgagtgagc aggtgttttg gacaatggac tggttgagcc catccctatt 360
ataaaaatgt ctcagagcaa ccgggagctg gtggttgact ttctctccta caagctttcc 420
cagaaaggat acagctggag tcagtttagt gatgtggaag agaacaggac tgaggcccca 480
gaagggactg aatcggagat ggagaccccc agtgccatca atggcaaccc atcctggcac 540
ctggcagaca gccccgcggt gaatggagcc actggccaca gcagcagttt ggatgcccgg 600
gaggtgatcc ccatggcagc agtaaagcaa gcgctgaggg aggcaggcga cgagtttgaa 660
ctgcggtacc ggcgggcatt cagtgacctg acatcccagc tccacatcac cccagggaca 720
gcatatcaga gctttgaaca ggtagtgaat gaactcttcc gggatggggt aaactggggt 780
cgcattgtgg cctttttctc cttcggcggg gcactgtgcg tggaaagcgt agacaaggag 840
atgcaggtat tggtgagtcg gatcgcagct tggatggcca cttacctgaa tgaccaccta 900
gagccttgga tccaggagaa cggcggctgg gatacttttg tggaactcta tgggaacaat 960
gcagcagccg agagccgaaa gggccaggaa cgcttcaacc gctggttcct gacgggcatg 1020
actgtggccg gcgtggttct gctgggctca ctcttcagtc ggaaatgacc agacactgac 1080
catccactct accctcccac ccccttctct gctccaccac atcctccgtc cagccgccat 1140
tgccaccagg agaaccacta catgcagccc atgcccacct gcccatcaca gggttgggcc 1200
cagatctggt cccttgcagc tagttttcta gaatttatca cacttctgtg agacccccac 1260
acctcagttc ccttggcctc agaattcaca aaatttccac aaaatctgtc caaaggaggc 1320
tggcaggtat ggaagggttt gtggctgggg gcaggagggc cctacctgat tggtgcaacc 1380
cttacccctt agcctccctg aaaatgtttt tctgccaggg agcttgaaag ttttcagaac 1440
ctcttcccca gaaaggagac tagattgcct ttgttttgat gtttgtggcc tcagaattga 1500
tcattttccc cccactctcc ccacactaac ctgggttccc tttccttcca tccctacccc 1560
ctaagagcca tttaggggcc acttttgact agggattcag gctgcttggg ataaagatgc 1620
aaggaccagg actccctcct cacctctgga ctggctagag tcctcactcc cagtccaaat 1680
gtcctccaga agcctctggc tagaggccag ccccacccag gagggagggg gctatagcta 1740
caggaagcac cccatgccaa agctagggtg gcccttgcag ttcagcacca ccctagtccc 1800
ttcccctccc tggctcccat gaccatactg agggaccaac tgggcccaag acagatgccc 1860
cagagctgtt tatggcctca gctgcctcac ttcctacaag agcagcctgt ggcatctttg 1920
ccttgggctg ctcctcatgg tgggttcagg ggactcagcc ctgaggtgaa agggagctat 1980
caggaacagc tatgggagcc ccagggtctt ccctacctca ggcaggaagg gcaggaagga 2040
gagcctgctg catggggtgg ggtagggctg actagaaggg ccagtcctgc ctggccaggc 2100
agatctgtgc cccatgcctg tccagcctgg gcagccaggc tgccaaggcc agagtggcct 2160
ggccaggagc tcttcaggcc tccctctctc ttctgctcca cccttggcct gtctcatccc 2220
caggggtccc agccaccccg ggctctctgc tgtacatatt tgagactagt ttttattcct 2280
tgtgaagatg atatactatt tttgttaagc gtgtctgtat ttatgtgtga ggagctgctg 2340
gcttgcagtg cgcgtgcacg tggagagctg gtgcccggag attggacggc ctgatgctcc 2400
ctcccctgcc ctggtccagg gaagctggcc gagggtcctg gctcctgagg ggcatctgcc 2460
cctcccccaa cccccacccc acacttgttc cagctctttg aaatagtctg tgtgaaggtg 2520
aaagtgcagt tcagtaataa actgtgttta ctcagtgaaa aaaaaaaaaa aaaaa      2575

<210> 52
<211> 233
<212> PRT
<213> Homo sapiens

<400> 52
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys
 1               5                  10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val
            180                 185                 190         
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys
225                 230             


<210> 53
<211> 4304
<212> DNA
<213> Homo sapiens

<400> 53
cacacggact acaggggagt tttgttgaag ttgcaaagtc ctggagcctc cagagggctg 60
tcggcgcagt agcagcgagc agcagagtcc gcacgctccg gcgaggggca gaagagcgcg 120
agggagcgcg gggcagcaga agcgagagcc gagcgcggac ccagccagga cccacagccc 180
tccccagctg cccaggaaga gccccagcca tggaacacca gctcctgtgc tgcgaagtgg 240
aaaccatccg ccgcgcgtac cccgatgcca acctcctcaa cgaccgggtg ctgcgggcca 300
tgctgaaggc ggaggagacc tgcgcgccct cggtgtccta cttcaaatgt gtgcagaagg 360
aggtcctgcc gtccatgcgg aagatcgtcg ccacctggat gctggaggtc tgcgaggaac 420
agaagtgcga ggaggaggtc ttcccgctgg ccatgaacta cctggaccgc ttcctgtcgc 480
tggagcccgt gaaaaagagc cgcctgcagc tgctgggggc cacttgcatg ttcgtggcct 540
ctaagatgaa ggagaccatc cccctgacgg ccgagaagct gtgcatctac accgacaact 600
ccatccggcc cgaggagctg ctgcaaatgg agctgctcct ggtgaacaag ctcaagtgga 660
acctggccgc aatgaccccg cacgatttca ttgaacactt cctctccaaa atgccagagg 720
cggaggagaa caaacagatc atccgcaaac acgcgcagac cttcgttgcc ctctgtgcca 780
cagatgtgaa gttcatttcc aatccgccct ccatggtggc agcggggagc gtggtggccg 840
cagtgcaagg cctgaacctg aggagcccca acaacttcct gtcctactac cgcctcacac 900
gcttcctctc cagagtgatc aagtgtgacc cggactgcct ccgggcctgc caggagcaga 960
tcgaagccct gctggagtca agcctgcgcc aggcccagca gaacatggac cccaaggccg 1020
ccgaggagga ggaagaggag gaggaggagg tggacctggc ttgcacaccc accgacgtgc 1080
gggacgtgga catctgaggg cgccaggcag gcgggcgcca ccgccacccg cagcgagggc 1140
ggagccggcc ccaggtgctc ccctgacagt ccctcctctc cggagcattt tgataccaga 1200
agggaaagct tcattctcct tgttgttggt tgttttttcc tttgctcttt cccccttcca 1260
tctctgactt aagcaaaaga aaaagattac ccaaaaactg tctttaaaag agagagagag 1320
aaaaaaaaaa tagtatttgc ataaccctga gcggtggggg aggagggttg tgctacagat 1380
gatagaggat tttatacccc aataatcaac tcgtttttat attaatgtac ttgtttctct 1440
gttgtaagaa taggcattaa cacaaaggag gcgtctcggg agaggattag gttccatcct 1500
ttacgtgttt aaaaaaaagc ataaaaacat tttaaaaaca tagaaaaatt cagcaaacca 1560
tttttaaagt agaagagggt tttaggtaga aaaacatatt cttgtgcttt tcctgataaa 1620
gcacagctgt agtggggttc taggcatctc tgtactttgc ttgctcatat gcatgtagtc 1680
actttataag tcattgtatg ttattatatt ccgtaggtag atgtgtaacc tcttcacctt 1740
attcatggct gaagtcacct cttggttaca gtagcgtagc gtgcccgtgt gcatgtcctt 1800
tgcgcctgtg accaccaccc caacaaacca tccagtgaca aaccatccag tggaggtttg 1860
tcgggcacca gccagcgtag cagggtcggg aaaggccacc tgtcccactc ctacgatacg 1920
ctactataaa gagaagacga aatagtgaca taatatattc tatttttata ctcttcctat 1980
ttttgtagtg acctgtttat gagatgctgg ttttctaccc aacggccctg cagccagctc 2040
acgtccaggt tcaacccaca gctacttggt ttgtgttctt cttcatattc taaaaccatt 2100
ccatttccaa gcactttcag tccaataggt gtaggaaata gcgctgtttt tgttgtgtgt 2160
gcagggaggg cagttttcta atggaatggt ttgggaatat ccatgtactt gtttgcaagc 2220
aggactttga ggcaagtgtg ggccactgtg gtggcagtgg aggtggggtg tttgggaggc 2280
tgcgtgccag tcaagaagaa aaaggtttgc attctcacat tgccaggatg ataagttcct 2340
ttccttttct ttaaagaagt tgaagtttag gaatcctttg gtgccaactg gtgtttgaaa 2400
gtagggacct cagaggttta cctagagaac aggtggtttt taagggttat cttagatgtt 2460
tcacaccgga aggtttttaa acactaaaat atataattta tagttaaggc taaaaagtat 2520
atttattgca gaggatgttc ataaggccag tatgatttat aaatgcaatc tccccttgat 2580
ttaaacacac agatacacac acacacacac acacacacaa accttctgcc tttgatgtta 2640
cagatttaat acagtttatt tttaaagata gatcctttta taggtgagaa aaaaacaatc 2700
tggaagaaaa aaaccacaca aagacattga ttcagcctgt ttggcgtttc ccagagtcat 2760
ctgattggac aggcatgggt gcaaggaaaa ttagggtact caacctaagt tcggttccga 2820
tgaattctta tcccctgccc cttcctttaa aaaacttagt gacaaaatag acaatttgca 2880
catcttggct atgtaattct tgtaattttt atttaggaag tgttgaaggg aggtggcaag 2940
agtgtggagg ctgacgtgtg agggaggaca ggcgggagga ggtgtgagga ggaggctccc 3000
gaggggaagg ggcggtgccc acaccgggga caggccgcag ctccattttc ttattgcgct 3060
gctaccgttg acttccaggc acggtttgga aatattcaca tcgcttctgt gtatctcttt 3120
cacattgttt gctgctattg gaggatcagt tttttgtttt acaatgtcat atactgccat 3180
gtactagttt tagttttctc ttagaacatt gtattacaga tgcctttttt gtagtttttt 3240
ttttttttat gtgatcaatt ttgacttaat gtgattactg ctctattcca aaaaggttgc 3300
tgtttcacaa tacctcatgc ttcacttagc catggtggac ccagcgggca ggttctgcct 3360
gctttggcgg gcagacacgc gggcgcgatc ccacacaggc tggcgggggc cggccccgag 3420
gccgcgtgcg tgagaaccgc gccggtgtcc ccagagacca ggctgtgtcc ctcttctctt 3480
ccctgcgcct gtgatgctgg gcacttcatc tgatcggggg cgtagcatca tagtagtttt 3540
tacagctgtg ttattctttg cgtgtagcta tggaagttgc ataattatta ttattattat 3600
tataacaagt gtgtcttacg tgccaccacg gcgttgtacc tgtaggactc tcattcggga 3660
tgattggaat agcttctgga atttgttcaa gttttgggta tgtttaatct gttatgtact 3720
agtgttctgt ttgttattgt tttgttaatt acaccataat gctaatttaa agagactcca 3780
aatctcaatg aagccagctc acagtgctgt gtgccccggt cacctagcaa gctgccgaac 3840
caaaagaatt tgcaccccgc tgcgggccca cgtggttggg gccctgccct ggcagggtca 3900
tcctgtgctc ggaggccatc tcgggcacag gcccaccccg ccccacccct ccagaacacg 3960
gctcacgctt acctcaacca tcctggctgc ggcgtctgtc tgaaccacgc gggggccttg 4020
agggacgctt tgtctgtcgt gatggggcaa gggcacaagt cctggatgtt gtgtgtatcg 4080
agaggccaaa ggctggtggc aagtgcacgg ggcacagcgg agtctgtcct gtgacgcgca 4140
agtctgaggg tctgggcggc gggcggctgg gtctgtgcat ttctggttgc accgcggcgc 4200
ttcccagcac caacatgtaa ccggcatgtt tccagcagaa gacaaaaaga caaacatgaa 4260
agtctagaaa taaaactggt aaaaccccaa aaaaaaaaaa aaaa                  4304

<210> 54
<211> 295
<212> PRT
<213> Homo sapiens

<400> 54
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala
 1               5                  10                  15      
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu
            20                  25                  30          
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val
        35                  40                  45              
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met
    50                  55                  60                  
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu
65                  70                  75                  80  
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys
                85                  90                  95      
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys
            100                 105                 110         
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr
        115                 120                 125             
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu
    130                 135                 140                 
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe
145                 150                 155                 160 
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln
                165                 170                 175     
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp
            180                 185                 190         
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val
        195                 200                 205             
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu
    210                 215                 220                 
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp
225                 230                 235                 240 
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu
                245                 250                 255     
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu
            260                 265                 270         
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr
        275                 280                 285             
Asp Val Arg Asp Val Asp Ile
    290                 295 


<210> 55
<211> 2655
<212> DNA
<213> Homo sapiens

<400> 55
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg 60
gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg 120
catgggtgcc ccgacgttgc cccctgcctg gcagcccttt ctcaaggacc accgcatctc 180
tacattcaag aactggccct tcttggaggg ctgcgcctgc accccggagc ggatggccga 240
ggctggcttc atccactgcc ccactgagaa cgagccagac ttggcccagt gtttcttctg 300
cttcaaggag ctggaaggct gggagccaga tgacgacccc atagaggaac ataaaaagca 360
ttcgtccggt tgcgctttcc tttctgtcaa gaagcagttt gaagaattaa cccttggtga 420
atttttgaaa ctggacagag aaagagccaa gaacaaaatt gcaaaggaaa ccaacaataa 480
gaagaaagaa tttgaggaaa ctgcggagaa agtgcgccgt gccatcgagc agctggctgc 540
catggattga ggcctctggc cggagctgcc tggtcccaga gtggctgcac cacttccagg 600
gtttattccc tggtgccacc agccttcctg tgggcccctt agcaatgtct taggaaagga 660
gatcaacatt ttcaaattag atgtttcaac tgtgctcttg ttttgtcttg aaagtggcac 720
cagaggtgct tctgcctgtg cagcgggtgc tgctggtaac agtggctgct tctctctctc 780
tctctctttt ttgggggctc atttttgctg ttttgattcc cgggcttacc aggtgagaag 840
tgagggagga agaaggcagt gtcccttttg ctagagctga cagctttgtt cgcgtgggca 900
gagccttcca cagtgaatgt gtctggacct catgttgttg aggctgtcac agtcctgagt 960
gtggacttgg caggtgcctg ttgaatctga gctgcaggtt ccttatctgt cacacctgtg 1020
cctcctcaga ggacagtttt tttgttgttg tgtttttttg tttttttttt tttggtagat 1080
gcatgacttg tgtgtgatga gagaatggag acagagtccc tggctcctct actgtttaac 1140
aacatggctt tcttattttg tttgaattgt taattcacag aatagcacaa actacaatta 1200
aaactaagca caaagccatt ctaagtcatt ggggaaacgg ggtgaacttc aggtggatga 1260
ggagacagaa tagagtgata ggaagcgtct ggcagatact ccttttgcca ctgctgtgtg 1320
attagacagg cccagtgagc cgcggggcac atgctggccg ctcctccctc agaaaaaggc 1380
agtggcctaa atccttttta aatgacttgg ctcgatgctg tgggggactg gctgggctgc 1440
tgcaggccgt gtgtctgtca gcccaacctt cacatctgtc acgttctcca cacgggggag 1500
agacgcagtc cgcccaggtc cccgctttct ttggaggcag cagctcccgc agggctgaag 1560
tctggcgtaa gatgatggat ttgattcgcc ctcctccctg tcatagagct gcagggtgga 1620
ttgttacagc ttcgctggaa acctctggag gtcatctcgg ctgttcctga gaaataaaaa 1680
gcctgtcatt tcaaacactg ctgtggaccc tactgggttt ttaaaatatt gtcagttttt 1740
catcgtcgtc cctagcctgc caacagccat ctgcccagac agccgcagtg aggatgagcg 1800
tcctggcaga gacgcagttg tctctgggcg cttgccagag ccacgaaccc cagacctgtt 1860
tgtatcatcc gggctccttc cgggcagaaa caactgaaaa tgcacttcag acccacttat 1920
ttctgccaca tctgagtcgg cctgagatag acttttccct ctaaactggg agaatatcac 1980
agtggttttt gttagcagaa aatgcactcc agcctctgta ctcatctaag ctgcttattt 2040
ttgatatttg tgtcagtctg taaatggata cttcacttta ataactgttg cttagtaatt 2100
ggctttgtag agaagctgga aaaaaatggt tttgtcttca actcctttgc atgccaggcg 2160
gtgatgtgga tctcggcttc tgtgagcctg tgctgtgggc agggctgagc tggagccgcc 2220
cctctcagcc cgcctgccac ggcctttcct taaaggccat ccttaaaacc agaccctcat 2280
ggctaccagc acctgaaagc ttcctcgaca tctgttaata aagccgtagg cccttgtcta 2340
agtgcaaccg cctagacttt ctttcagata catgtccaca tgtccatttt tcaggttctc 2400
taagttggag tggagtctgg gaagggttgt gaatgaggct tctgggctat gggtgaggtt 2460
ccaatggcag gttagagccc ctcgggccaa ctgccatcct ggaaagtaga gacagcagtg 2520
cccgctgccc agaagagacc agcaagccaa actggagccc ccattgcagg ctgtcgccat 2580
gtggaaagag taactcacaa ttgccaataa agtctcatgt ggttttatct aaaaaaaaaa 2640
aaaaaaaaaa aaaaa                                                  2655

<210> 56
<211> 142
<212> PRT
<213> Homo sapiens

<400> 56
Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp
 1               5                  10                  15      
His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala
            20                  25                  30          
Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr
        35                  40                  45              
Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu
    50                  55                  60                  
Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His
65                  70                  75                  80  
Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu
                85                  90                  95      
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys
            100                 105                 110         
Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala
        115                 120                 125             
Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp
    130                 135                 140         


<210> 57
<211> 6492
<212> DNA
<213> Homo sapiens

<400> 57
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct 60
ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag 120
attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga 180
ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata 240
cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt 300
cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac 360
cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct 420
ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt 480
tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat 540
gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg 600
cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac 660
gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc 720
tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac 780
cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc 840
cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga 900
gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt 960
catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg 1020
gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctggga 1080
tgcctttgtg gaactgtacg gccccagcat gcggcctctg tttgatttct cctggctgtc 1140
tctgaagact ctgctcagtt tggccctggt gggagcttgc atcaccctgg gtgcctatct 1200
gggccacaag tgaagtcaac atgcctgccc caaacaaata tgcaaaaggt tcactaaagc 1260
agtagaaata atatgcattg tcagtgatgt accatgaaac aaagctgcag gctgtttaag 1320
aaaaaataac acacatataa acatcacaca cacagacaga cacacacaca cacaacaatt 1380
aacagtcttc aggcaaaacg tcgaatcagc tatttactgc caaagggaaa tatcatttat 1440
tttttacatt attaagaaaa aaagatttat ttatttaaga cagtcccatc aaaactcctg 1500
tctttggaaa tccgaccact aattgccaag caccgcttcg tgtggctcca cctggatgtt 1560
ctgtgcctgt aaacatagat tcgctttcca tgttgttggc cggatcacca tctgaagagc 1620
agacggatgg aaaaaggacc tgatcattgg ggaagctggc tttctggctg ctggaggctg 1680
gggagaaggt gttcattcac ttgcatttct ttgccctggg ggctgtgata ttaacagagg 1740
gagggttcct gtggggggaa gtccatgcct ccctggcctg aagaagagac tctttgcata 1800
tgactcacat gatgcatacc tggtgggagg aaaagagttg ggaacttcag atggacctag 1860
tacccactga gatttccacg ccgaaggaca gcgatgggaa aaatgccctt aaatcatagg 1920
aaagtatttt tttaagctac caattgtgcc gagaaaagca ttttagcaat ttatacaata 1980
tcatccagta ccttaagccc tgattgtgta tattcatata ttttggatac gcacccccca 2040
actcccaata ctggctctgt ctgagtaaga aacagaatcc tctggaactt gaggaagtga 2100
acatttcggt gacttccgca tcaggaaggc tagagttacc cagagcatca ggccgccaca 2160
agtgcctgct tttaggagac cgaagtccgc agaacctgcc tgtgtcccag cttggaggcc 2220
tggtcctgga actgagccgg ggccctcact ggcctcctcc agggatgatc aacagggcag 2280
tgtggtctcc gaatgtctgg aagctgatgg agctcagaat tccactgtca agaaagagca 2340
gtagaggggt gtggctgggc ctgtcaccct ggggccctcc aggtaggccc gttttcacgt 2400
ggagcatggg agccacgacc cttcttaaga catgtatcac tgtagaggga aggaacagag 2460
gccctgggcc cttcctatca gaaggacatg gtgaaggctg ggaacgtgag gagaggcaat 2520
ggccacggcc cattttggct gtagcacatg gcacgttggc tgtgtggcct tggcccacct 2580
gtgagtttaa agcaaggctt taaatgactt tggagagggt cacaaatcct aaaagaagca 2640
ttgaagtgag gtgtcatgga ttaattgacc cctgtctatg gaattacatg taaaacatta 2700
tcttgtcact gtagtttggt tttatttgaa aacctgacaa aaaaaaagtt ccaggtgtgg 2760
aatatggggg ttatctgtac atcctggggc attaaaaaaa aaatcaatgg tggggaacta 2820
taaagaagta acaaaagaag tgacatcttc agcaaataaa ctaggaaatt tttttttctt 2880
ccagtttaga atcagccttg aaacattgat ggaataactc tgtggcatta ttgcattata 2940
taccatttat ctgtattaac tttggaatgt actctgttca atgtttaatg ctgtggttga 3000
tatttcgaaa gctgctttaa aaaaatacat gcatctcagc gtttttttgt ttttaattgt 3060
atttagttat ggcctataca ctatttgtga gcaaaggtga tcgttttctg tttgagattt 3120
ttatctcttg attcttcaaa agcattctga gaaggtgaga taagccctga gtctcagcta 3180
cctaagaaaa acctggatgt cactggccac tgaggagctt tgtttcaacc aagtcatgtg 3240
catttccacg tcaacagaat tgtttattgt gacagttata tctgttgtcc ctttgacctt 3300
gtttcttgaa ggtttcctcg tccctgggca attccgcatt taattcatgg tattcaggat 3360
tacatgcatg tttggttaaa cccatgagat tcattcagtt aaaaatccag atggcaaatg 3420
accagcagat tcaaatctat ggtggtttga cctttagaga gttgctttac gtggcctgtt 3480
tcaacacaga cccacccaga gccctcctgc cctccttccg cgggggcttt ctcatggctg 3540
tccttcaggg tcttcctgaa atgcagtggt gcttacgctc caccaagaaa gcaggaaacc 3600
tgtggtatga agccagacct ccccggcggg cctcagggaa cagaatgatc agacctttga 3660
atgattctaa tttttaagca aaatattatt ttatgaaagg tttacattgt caaagtgatg 3720
aatatggaat atccaatcct gtgctgctat cctgccaaaa tcattttaat ggagtcagtt 3780
tgcagtatgc tccacgtggt aagatcctcc aagctgcttt agaagtaaca atgaagaacg 3840
tggacgtttt taatataaag cctgttttgt cttttgttgt tgttcaaacg ggattcacag 3900
agtatttgaa aaatgtatat atattaagag gtcacggggg ctaattgctg gctggctgcc 3960
ttttgctgtg gggttttgtt acctggtttt aataacagta aatgtgccca gcctcttggc 4020
cccagaactg tacagtattg tggctgcact tgctctaaga gtagttgatg ttgcattttc 4080
cttattgtta aaaacatgtt agaagcaatg aatgtatata aaagcctcaa ctagtcattt 4140
ttttctcctc ttcttttttt tcattatatc taattatttt gcagttgggc aacagagaac 4200
catccctatt ttgtattgaa gagggattca catctgcatc ttaactgctc tttatgaatg 4260
aaaaaacagt cctctgtatg tactcctctt tacactggcc agggtcagag ttaaatagag 4320
tatatgcact ttccaaattg gggacaaggg ctctaaaaaa agccccaaaa ggagaagaac 4380
atctgagaac ctcctcggcc ctcccagtcc ctcgctgcac aaatactccg caagagaggc 4440
cagaatgaca gctgacaggg tctatggcca tcgggtcgtc tccgaagatt tggcaggggc 4500
agaaaactct ggcaggctta agatttggaa taaagtcaca gaattaagga agcacctcaa 4560
tttagttcaa acaagacgcc aacattctct ccacagctca cttacctctc tgtgttcaga 4620
tgtggccttc catttatatg tgatctttgt tttattagta aatgcttatc atctaaagat 4680
gtagctctgg cccagtggga aaaattagga agtgattata aatcgagagg agttataata 4740
atcaagatta aatgtaaata atcagggcaa tcccaacaca tgtctagctt tcacctccag 4800
gatctattga gtgaacagaa ttgcaaatag tctctatttg taattgaact tatcctaaaa 4860
caaatagttt ataaatgtga acttaaactc taattaattc caactgtact tttaaggcag 4920
tggctgtttt tagactttct tatcacttat agttagtaat gtacacctac tctatcagag 4980
aaaaacagga aaggctcgaa atacaagcca ttctaaggaa attagggagt cagttgaaat 5040
tctattctga tcttattctg tggtgtcttt tgcagcccag acaaatgtgg ttacacactt 5100
tttaagaaat acaattctac attgtcaagc ttatgaaggt tccaatcaga tctttattgt 5160
tattcaattt ggatctttca gggatttttt ttttaaatta ttatgggaca aaggacattt 5220
gttggagggg tgggagggag gaagaatttt taaatgtaaa acattcccaa gtttggatca 5280
gggagttgga agttttcaga ataaccagaa ctaagggtat gaaggacctg tattggggtc 5340
gatgtgatgc ctctgcgaag aaccttgtgt gacaaatgag aaacattttg aagtttgtgg 5400
tacgaccttt agattccaga gacatcagca tggctcaaag tgcagctccg tttggcagtg 5460
caatggtata aatttcaagc tggatatgtc taatgggtat ttaaacaata aatgtgcagt 5520
tttaactaac aggatattta atgacaacct tctggttggt agggacatct gtttctaaat 5580
gtttattatg tacaatacag aaaaaaattt tataaaatta agcaatgtga aactgaattg 5640
gagagtgata atacaagtcc tttagtctta cccagtgaat cattctgttc catgtctttg 5700
gacaaccatg accttggaca atcatgaaat atgcatctca ctggatgcaa agaaaatcag 5760
atggagcatg aatggtactg taccggttca tctggactgc cccagaaaaa taacttcaag 5820
caaacatcct atcaacaaca aggttgttct gcataccaag ctgagcacag aagatgggaa 5880
cactggtgga ggatggaaag gctcgctcaa tcaagaaaat tctgagacta ttaataaata 5940
agactgtagt gtagatactg agtaaatcca tgcacctaaa ccttttggaa aatctgccgt 6000
gggccctcca gatagctcat ttcattaagt ttttccctcc aaggtagaat ttgcaagagt 6060
gacagtggat tgcatttctt ttggggaagc tttcttttgg tggttttgtt tattatacct 6120
tcttaagttt tcaaccaagg tttgcttttg ttttgagtta ctggggttat ttttgtttta 6180
aataaaaata agtgtacaat aagtgttttt gtattgaaag cttttgttat caagattttc 6240
atacttttac cttccatggc tctttttaag attgatactt ttaagaggtg gctgatattc 6300
tgcaacactg tacacataaa aaatacggta aggatacttt acatggttaa ggtaaagtaa 6360
gtctccagtt ggccaccatt agctataatg gcactttgtt tgtgttgttg gaaaaagtca 6420
cattgccatt aaactttcct tgtctgtcta gttaatattg tgaagaaaaa taaagtacag 6480
tgtgagatac tg                                                     6492



<210> 58
<211> 239
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met
 1               5                  10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala
            20                  25                  30          
Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile
        35                  40                  45              
Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp
    50                  55                  60                  
Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala
65                  70                  75                  80  
Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr
                85                  90                  95      
Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe
            100                 105                 110         
Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly
        115                 120                 125             
Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp
    130                 135                 140                 
Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu
145                 150                 155                 160 
Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp
                165                 170                 175     
Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn
            180                 185                 190         
Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro
        195                 200                 205             
Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala
    210                 215                 220                 
Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys
225                 230                 235                 

