
                                SEQUENCE LISTING

<110> Mayo Foundation for Medical Education and Research

<120> METHODS FOR TREATING CANCER IN PATIENTS
  WITH ELEVATED LEVELS OF BIM
  

<130> 07039-1283WO1

<150> US 61/885,218       
<151> 2013-10-01  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 873
<212> DNA
<213> Homo sapiens

<400> 1
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact 60
gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc 120
aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag 180
gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc 240
tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag 300
atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt 360
gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga 420
attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac 480
cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc 540
accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac 600
acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat 660
acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac 720
ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt 780
ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag 840
aagcaaagtg atacacattt ggaggagacg taa                              873

<210> 2
<211> 290
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225                 230                 235                 240 
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
                245                 250                 255     
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
            260                 265                 270         
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
        275                 280                 285             
Glu Thr
    290 


<210> 3
<211> 948
<212> DNA
<213> Homo sapiens

<400> 3
gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc agatcccaca 60
ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag gatggttctt 120
agactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc tcgtggtgac 180
cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga gcttcgtgct 240
aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgctt tccccgagga 300
ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca acgggcgtga 360
cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc tctgtggggc 420
catctccctg gcccccaagg cgcagatcaa agagagcctg cgggcagagc tcagggtgac 480
agagagaagg gcagaagtgc ccacagccca ccccagcccc tcacccaggc cagccggcca 540
gttccaaacc ctggtggttg gtgtcgtggg cggcctgctg ggcagcctgg tgctgctagt 600
ctgggtcctg gccgtcatct gctcccgggc cgcacgaggg acaataggag ccaggcgcac 660
cggccagccc ctgaaggagg acccctcagc cgtgcctgtg ttctctgtgg actatgggga 720
gctggatttc cagtggcgag agaagacccc ggagcccccc gtgccctgtg tccctgagca 780
gacggagtat gccaccattg tctttcctag cggaatgggc acctcatccc ccgcccgcag 840
gggctcagcc gacggccctc ggagtgccca gccactgagg cctgaggatg gacactgctc 900
ttggcccctc tgaccggctt ccttggccac cagtgttctg cagaccct              948

<210> 4
<211> 288
<212> PRT
<213> Homo sapiens

<400> 4
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
 1               5                  10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly
                165                 170                 175     
Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys
            180                 185                 190         
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro
        195                 200                 205             
Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly
    210                 215                 220                 
Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro
225                 230                 235                 240 
Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly
                245                 250                 255     
Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg
            260                 265                 270         
Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
        275                 280                 285             


<210> 5
<211> 2757
<212> DNA
<213> Homo sapiens

<400> 5
gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt 60
cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga 120
agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga 180
atttttcttc agcaagctgt gaaactaaat ccacaacctt tggagaccca ggaacaccct 240
ccaatctctg tgtgttttgt aaacatcact ggagggtctt ctacgtgagc aattggattg 300
tcatcagccc tgcctgtttt gcacctggga agtgccctgg tcttacttgg gtccaaattg 360
ttggctttca cttttgaccc taagcatctg aagccatggg ccacacacgg aggcagggaa 420
catcaccatc caagtgtcca tacctcaatt tctttcagct cttggtgctg gctggtcttt 480
ctcacttctg ttcaggtgtt atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt 540
cctgtggtca caatgtttct gttgaagagc tggcacaaac tcgcatctac tggcaaaagg 600
agaagaaaat ggtgctgact atgatgtctg gggacatgaa tatatggccc gagtacaaga 660
accggaccat ctttgatatc actaataacc tctccattgt gatcctggct ctgcgcccat 720
ctgacgaggg cacatacgag tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg 780
aacacctggc tgaagtgacg ttatcagtca aagctgactt ccctacacct agtatatctg 840
actttgaaat tccaacttct aatattagaa ggataatttg ctcaacctct ggaggttttc 900
cagagcctca cctctcctgg ttggaaaatg gagaagaatt aaatgccatc aacacaacag 960
tttcccaaga tcctgaaact gagctctatg ctgttagcag caaactggat ttcaatatga 1020
caaccaacca cagcttcatg tgtctcatca agtatggaca tttaagagtg aatcagacct 1080
tcaactggaa tacaaccaag caagagcatt ttcctgataa cctgctccca tcctgggcca 1140
ttaccttaat ctcagtaaat ggaatttttg tgatatgctg cctgacctac tgctttgccc 1200
caagatgcag agagagaagg aggaatgaga gattgagaag ggaaagtgta cgccctgtat 1260
aacagtgtcc gcagaagcaa ggggctgaaa agatctgaag gtcccacctc catttgcaat 1320
tgacctcttc tgggaacttc ctcagatgga caagattacc ccaccttgcc ctttacgtat 1380
ctgctcttag gtgcttcttc acttcagttg ctttgcagga agtgtctaga ggaatatggt 1440
gggcacagaa gtagctctgg tgaccttgat caaggtgttt tgaaatgcag aattcttgag 1500
ttctggaagg gactttagag aataccagtg ttattaatga caaaggcact gaggcccagg 1560
gaggtgaccc gaattataaa ggccagcgcc agaacccaga tttcctaact ctggtgctct 1620
ttccctttat cagtttgact gtggcctgtt aactggtata tacatatata tgtcaggcaa 1680
agtgctgctg gaagtagaat ttgtccaata acaggtcaac ttcagagact atctgatttc 1740
ctaatgtcag agtagaagat tttatgctgc tgtttacaaa agcccaatgt aatgcatagg 1800
aagtatggca tgaacatctt taggagacta atggaaatat tattggtgtt tacccagtat 1860
tccatttttt tcattgtgtt ctctattgct gctctctcac tcccccatga ggtacagcag 1920
aaaggagaac tatccaaaac taatttcctc tgacatgtaa gacgaatgat ttaggtacgt 1980
caaagcagta gtcaaggagg aaagggatag tccaaagact taactggttc atattggact 2040
gataatctct ttaaatggct ttatgctagt ttgacctcat ttgtaaaata tttatgagaa 2100
agttctcatt taaaatgaga tcgttgttta cagtgtatgt actaagcagt aagctatctt 2160
caaatgtcta aggtagtaac tttccatagg gcctccttag atccctaaga tggctttttc 2220
tccttggtat ttctgggtct ttctgacatc agcagagaac tggaaagaca tagccaactg 2280
ctgttcatgt tactcatgac tcctttctct aaaactgcct tccacaattc actagaccag 2340
aagtggacgc aacttaagct gggataatca cattatcatc tgaaaatctg gagttgaaca 2400
gcaaaagaag acaacatttc tcaaatgcac atctcatggc agctaagcca catggctggg 2460
atttaaagcc tttagagcca gcccatggct ttagctacct cactatgctg cttcacaaac 2520
cttgctcctg tgtaaaacta tattctcagt gtagggcaga gaggtctaac accaacataa 2580
ggtactagca gtgtttcccg tattgacagg aatacttaac tcaataattc ttttcttttc 2640
catttagtaa cagttgtgat gactatgttt ctattctaag taattcctgt attctacagc 2700
agatactttg tcagcaatac taagggaaga aacaaagttg aaccgtttct ttaataa    2757

<210> 6
<211> 288
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15      
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30          
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45              
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60                  
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80  
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95      
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110         
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125             
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140                 
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160 
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175     
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190         
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205             
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220                 
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240 
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255     
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270         
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285             

