                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum
	Ruprecht-Karls-Universitt Heidelberg
 
<120>  non-ribosomal protein synthesis pigment fusion peptides

<130>  DK12217PC

<160>  39    

<170>  PatentIn version 3.3

<210>  1
<211>  3855
<212>  DNA
<213>  Photorhabdus luminescens

<400>  1
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact gaaataaggc ttggaaaaat ttggatggaa   2880

gtactgaaat gggattcagt atctgccctc gatgattttt tcgaaagtgg gggtaattct   2940

ttgatggccg ttgcaatggt taataagatc aatgcggcct ttaatattcg ttttccgtta   3000

cagatacttt ttcaatctcc taatatagca gaattggcta agtggattga acagacagac   3060

tctaaaacaa tatcaagatt aattttattg aatcaggcaa gcaaagaccc catttactgt   3120

tggccgggtt tgggcggata tcctatgagt ttgagattgc ttgctaataa agtcgttcct   3180

gatcgggcat tttatggaat acaggcatat gggataaacg agagtgaaat accgttttct   3240

tctatccaga gaatggcaga agaggatatt aaagagataa agaaaataca gccagaaggg   3300

ccatatatat tgtggggata ttcatttggt gcccgagtag catttgaagt tgcataccag   3360

cttgaacaag cgggagaaga agttaacgca ttgaatttat tggctccggg atctcctcat   3420

cttgatatga agcaagcgga atatatggat aaaggcgctg aatttactaa tccggctttt   3480

gttaaaatac ttttttctgt attttctcgt tcaatcaaca gcccaatggt taaaacttgc   3540

ttagaacaag taaatagtga aacgacattt attaacttta tatgtagtcg ttttaaaaac   3600

ttggaaccat cattagtaaa acgtatcgtt aggattgtga ctttgactta tgatttcaag   3660

tacagtattg atgagcttta tcacagacac ctaaaggcac ctataactat tttcaaggcg   3720

aatagagata atgattcatt tatcgaggaa tcggatgtga tttcatcaat gtcgcctaaa   3780

ataattgaat taatatcgga tcactatcaa ctgttggaaa gtgaaggtgt tgctgagatt   3840

gagaaaataa tctaa                                                    3855


<210>  2
<211>  4402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with a ccdB gene which is toxic to 
       normal E. coli cells. We used this variant to easily exchange 
       T-domains without any background cells.

<400>  2
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact actggctgtg tataagggag cctgacattt   2880

atattcccca gaacatcagg ttaatggcgt ttttgatgtc attttcgcgg tggctgagat   2940

cagccacttc ttccccgata acggagaccg gcacactggc catatcggtg gtcatcatgc   3000

gccagctttc atccccgata tgcaccaccg ggtaaagttc acgggagact ttatctgaca   3060

gcagacgtgc actggccagg gggatcacca tccgtcgccc gggcgtgtca ataatatcac   3120

tctgtacatc cacaaacaga cgataacggc tctctctttt ataggtgtaa accttaaact   3180

gcatttcacc agcccctgtt ctcgtcagca aaagagccgt tcatttcaat aaaccgggcg   3240

acctcagcca tcccttcctg attttccgct ttccagcgtt cggcacgcag acgacgggct   3300

tcattctgca tggttgtgct taccagaccg gagatattga catcatatat gccttgagca   3360

actgatagct gtcgctgtca actgtcactg taatacgctg cttcatagca tacctctttt   3420

tgacatactt cgggtataca tatcagtata tattcttata ccgcaaaaat cagcgcgcaa   3480

atacgcatac tgttatctgg cttttagtaa gccggatcca cgcgccttta atattcgttt   3540

tccgttacag atactttttc aatctcctaa tatagcagaa ttggctaagt ggattgaaca   3600

gacagactct aaaacaatat caagattaat tttattgaat caggcaagca aagaccccat   3660

ttactgttgg ccgggtttgg gcggatatcc tatgagtttg agattgcttg ctaataaagt   3720

cgttcctgat cgggcatttt atggaataca ggcatatggg ataaacgaga gtgaaatacc   3780

gttttcttct atccagagaa tggcagaaga ggatattaaa gagataaaga aaatacagcc   3840

agaagggcca tatatattgt ggggatattc atttggtgcc cgagtagcat ttgaagttgc   3900

ataccagctt gaacaagcgg gagaagaagt taacgcattg aatttattgg ctccgggatc   3960

tcctcatctt gatatgaagc aagcggaata tatggataaa ggcgctgaat ttactaatcc   4020

ggcttttgtt aaaatacttt tttctgtatt ttctcgttca atcaacagcc caatggttaa   4080

aacttgctta gaacaagtaa atagtgaaac gacatttatt aactttatat gtagtcgttt   4140

taaaaacttg gaaccatcat tagtaaaacg tatcgttagg attgtgactt tgacttatga   4200

tttcaagtac agtattgatg agctttatca cagacaccta aaggcaccta taactatttt   4260

caaggcgaat agagataatg attcatttat cgaggaatcg gatgtgattt catcaatgtc   4320

gcctaaaata attgaattaa tatcggatca ctatcaactg ttggaaagtg aaggtgttgc   4380

tgagattgag aaaataatct aa                                            4402


<210>  3
<211>  4004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with the T-domain of the bpsA 
       indigoidine synthetase from Streptomyces lavendulae lavendulae 
       ATCC11924

<400>  3
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaagatcg atgtgaaagc actggccgct tctgaccagg tcaacgctga gctggtggaa   2820

cggcccttcg tcgcacctag gaccgaaaca gagaaggaaa tcgcagccgt gtgggagaaa   2880

gccctgagac gcgaaaatgc tagtgtccag gacgatttct ttgagtccgg cggaaactct   2940

ctgatcgccg tcggcctggt gagggaactg aatgctagac tgggagtgtc cctgcctctg   3000

cagagtgtcc tggagtcacc aacaattgaa aagctggccg ggattcagta tctgccctcg   3060

atgatttttt cgaaagtggg ggtaattctt tgatggccgt tgcaatggtt aataagatca   3120

atgcggcctt taatattcgt tttccgttac agatactttt tcaatctcct aatatagcag   3180

aattggctaa gtggattgaa cagacagact ctaaaacaat atcaagatta attttattga   3240

atcaggcaag caaagacccc atttactgtt ggccgggttt gggcggatat cctatgagtt   3300

tgagattgct tgctaataaa gtcgttcctg atcgggcatt ttatggaata caggcatatg   3360

ggataaacga gagtgaaata ccgttttctt ctatccagag aatggcagaa gaggatatta   3420

aagagataaa gaaaatacag ccagaagggc catatatatt gtggggatat tcatttggtg   3480

cccgagtagc atttgaagtt gcataccagc ttgaacaagc gggagaagaa gttaacgcat   3540

tgaatttatt ggctccggga tctcctcatc ttgatatgaa gcaagcggaa tatatggata   3600

aaggcgctga atttactaat ccggcttttg ttaaaatact tttttctgta ttttctcgtt   3660

caatcaacag cccaatggtt aaaacttgct tagaacaagt aaatagtgaa acgacattta   3720

ttaactttat atgtagtcgt tttaaaaact tggaaccatc attagtaaaa cgtatcgtta   3780

ggattgtgac tttgacttat gatttcaagt acagtattga tgagctttat cacagacacc   3840

taaaggcacc tataactatt ttcaaggcga atagagataa tgattcattt atcgaggaat   3900

cggatgtgat ttcatcaatg tcgcctaaaa taattgaatt aatatcggat cactatcaac   3960

tgttggaaag tgaaggtgtt gctgagattg agaaaataat ctaa                    4004


<210>  4
<211>  3995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with the T-domain of the plu2642 
       protein from P. luminescens

<400>  4
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaaatcg atttcgacac attacaagta ctggtcagca cagtatcaca cagtccacag   2820

gtactcccaa gcacctcgac agaaacacag atcgtaaaga tatgggaaga agtgctaacg   2880

cgagaaagca tatctaccga agatgacttc tttgctttag gtggcaattc tctgatagcc   2940

gtccatctga tacaacgttt aaatgaagaa tttgcgttat cgctacctct ccatactcta   3000

tttgaggccg caacggttaa acaattggca gggattcagt atctgccctc gatgattttt   3060

tcgaaagtgg gggtaattct ttgatggccg ttgcaatggt taataagatc aatgcggcct   3120

ttaatattcg ttttccgtta cagatacttt ttcaatctcc taatatagca gaattggcta   3180

agtggattga acagacagac tctaaaacaa tatcaagatt aattttattg aatcaggcaa   3240

gcaaagaccc catttactgt tggccgggtt tgggcggata tcctatgagt ttgagattgc   3300

ttgctaataa agtcgttcct gatcgggcat tttatggaat acaggcatat gggataaacg   3360

agagtgaaat accgttttct tctatccaga gaatggcaga agaggatatt aaagagataa   3420

agaaaataca gccagaaggg ccatatatat tgtggggata ttcatttggt gcccgagtag   3480

catttgaagt tgcataccag cttgaacaag cgggagaaga agttaacgca ttgaatttat   3540

tggctccggg atctcctcat cttgatatga agcaagcgga atatatggat aaaggcgctg   3600

aatttactaa tccggctttt gttaaaatac ttttttctgt attttctcgt tcaatcaaca   3660

gcccaatggt taaaacttgc ttagaacaag taaatagtga aacgacattt attaacttta   3720

tatgtagtcg ttttaaaaac ttggaaccat cattagtaaa acgtatcgtt aggattgtga   3780

ctttgactta tgatttcaag tacagtattg atgagcttta tcacagacac ctaaaggcac   3840

ctataactat tttcaaggcg aatagagata atgattcatt tatcgaggaa tcggatgtga   3900

tttcatcaat gtcgcctaaa ataattgaat taatatcgga tcactatcaa ctgttggaaa   3960

gtgaaggtgt tgctgagatt gagaaaataa tctaa                              3995


<210>  5
<211>  3983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with the T-domain of the delH4 
       protein from Delftia acidovorans SPH-1

<400>  5
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaagctgg accggcaggc cctgcccgcg ttcggcatgc cagccgccag ccaggctccc   2820

gagggcgaac tggagacgct gctggcccgt atctgggccg aggtgctggg cctggagcgg   2880

gtggggcgca gcgacaactt cttcgcgctg ggcggtgatt ccatcctggg cctgcagatc   2940

gtctcgcgcc tgcgccgctt cggctggaag ctgtcgccac ggcagctgtt cgagcggcaa   3000

agcattgccg agctggcggg gattcagtat ctgccctcga tgattttttc gaaagtgggg   3060

gtaattcttt gatggccgtt gcaatggtta ataagatcaa tgcggccttt aatattcgtt   3120

ttccgttaca gatacttttt caatctccta atatagcaga attggctaag tggattgaac   3180

agacagactc taaaacaata tcaagattaa ttttattgaa tcaggcaagc aaagacccca   3240

tttactgttg gccgggtttg ggcggatatc ctatgagttt gagattgctt gctaataaag   3300

tcgttcctga tcgggcattt tatggaatac aggcatatgg gataaacgag agtgaaatac   3360

cgttttcttc tatccagaga atggcagaag aggatattaa agagataaag aaaatacagc   3420

cagaagggcc atatatattg tggggatatt catttggtgc ccgagtagca tttgaagttg   3480

cataccagct tgaacaagcg ggagaagaag ttaacgcatt gaatttattg gctccgggat   3540

ctcctcatct tgatatgaag caagcggaat atatggataa aggcgctgaa tttactaatc   3600

cggcttttgt taaaatactt ttttctgtat tttctcgttc aatcaacagc ccaatggtta   3660

aaacttgctt agaacaagta aatagtgaaa cgacatttat taactttata tgtagtcgtt   3720

ttaaaaactt ggaaccatca ttagtaaaac gtatcgttag gattgtgact ttgacttatg   3780

atttcaagta cagtattgat gagctttatc acagacacct aaaggcacct ataactattt   3840

tcaaggcgaa tagagataat gattcattta tcgaggaatc ggatgtgatt tcatcaatgt   3900

cgcctaaaat aattgaatta atatcggatc actatcaact gttggaaagt gaaggtgttg   3960

ctgagattga gaaaataatc taa                                           3983


<210>  6
<211>  3917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with a synthetic T-domain of our own
       design (variant 1)

<400>  6
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact gaaatccgtc tggcgaaaat ctggatggaa   2880

gttctgaaat gggactctgt ttctgcgctg gacgacttct tcgaatctgg tggtaactct   2940

ctgatggcgg ttgcgctggt taacaaaatc aacgcggcgt tcaacatccg tctgccgctg   3000

caaatcctgt tccagtctcc gaccatcgcg gaactggcgc ctttaatatt cgttttccgt   3060

tacagatact ttttcaatct cctaatatag cagaattggc taagtggatt gaacagacag   3120

actctaaaac aatatcaaga ttaattttat tgaatcaggc aagcaaagac cccatttact   3180

gttggccggg tttgggcgga tatcctatga gtttgagatt gcttgctaat aaagtcgttc   3240

ctgatcgggc attttatgga atacaggcat atgggataaa cgagagtgaa ataccgtttt   3300

cttctatcca gagaatggca gaagaggata ttaaagagat aaagaaaata cagccagaag   3360

ggccatatat attgtgggga tattcatttg gtgcccgagt agcatttgaa gttgcatacc   3420

agcttgaaca agcgggagaa gaagttaacg cattgaattt attggctccg ggatctcctc   3480

atcttgatat gaagcaagcg gaatatatgg ataaaggcgc tgaatttact aatccggctt   3540

ttgttaaaat acttttttct gtattttctc gttcaatcaa cagcccaatg gttaaaactt   3600

gcttagaaca agtaaatagt gaaacgacat ttattaactt tatatgtagt cgttttaaaa   3660

acttggaacc atcattagta aaacgtatcg ttaggattgt gactttgact tatgatttca   3720

agtacagtat tgatgagctt tatcacagac acctaaaggc acctataact attttcaagg   3780

cgaatagaga taatgattca tttatcgagg aatcggatgt gatttcatca atgtcgccta   3840

aaataattga attaatatcg gatcactatc aactgttgga aagtgaaggt gttgctgaga   3900

ttgagaaaat aatctaa                                                  3917


<210>  7
<211>  3917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with a synthetic T-domain of our own
       design (variant 3)

<400>  7
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact gaaatccgtc tgggtaaaat ctggatggaa   2880

gttctgaaat gggactctgt tggtgcgctg gacgacttct tcgaactggg tggtcactct   2940

ctgatggcgg ttgcgatggt taacaaaatc aacgcggcgt tcaacatccg tctgccgctg   3000

caaatcctgt tccagtctcc gaccatcgcg gaactggcgc ctttaatatt cgttttccgt   3060

tacagatact ttttcaatct cctaatatag cagaattggc taagtggatt gaacagacag   3120

actctaaaac aatatcaaga ttaattttat tgaatcaggc aagcaaagac cccatttact   3180

gttggccggg tttgggcgga tatcctatga gtttgagatt gcttgctaat aaagtcgttc   3240

ctgatcgggc attttatgga atacaggcat atgggataaa cgagagtgaa ataccgtttt   3300

cttctatcca gagaatggca gaagaggata ttaaagagat aaagaaaata cagccagaag   3360

ggccatatat attgtgggga tattcatttg gtgcccgagt agcatttgaa gttgcatacc   3420

agcttgaaca agcgggagaa gaagttaacg cattgaattt attggctccg ggatctcctc   3480

atcttgatat gaagcaagcg gaatatatgg ataaaggcgc tgaatttact aatccggctt   3540

ttgttaaaat acttttttct gtattttctc gttcaatcaa cagcccaatg gttaaaactt   3600

gcttagaaca agtaaatagt gaaacgacat ttattaactt tatatgtagt cgttttaaaa   3660

acttggaacc atcattagta aaacgtatcg ttaggattgt gactttgact tatgatttca   3720

agtacagtat tgatgagctt tatcacagac acctaaaggc acctataact attttcaagg   3780

cgaatagaga taatgattca tttatcgagg aatcggatgt gatttcatca atgtcgccta   3840

aaataattga attaatatcg gatcactatc aactgttgga aagtgaaggt gttgctgaga   3900

ttgagaaaat aatctaa                                                  3917


<210>  8
<211>  3917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with a synthetic T-domain of our own
       design (variant 4)

<400>  8
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact gaaatccgtc tggcgaaaat ctggatggaa   2880

gttctgggtt gggactctgt ttctgcgctg gacgacttct tcgaactggg tggtaactct   2940

ctgatggcgg ttgcgatggt taacaaaatc aacgcggcgt tcaacatccg tttcccgctg   3000

caaatcctgt tccagtctcc gaccatcgcg gaactggcgc ctttaatatt cgttttccgt   3060

tacagatact ttttcaatct cctaatatag cagaattggc taagtggatt gaacagacag   3120

actctaaaac aatatcaaga ttaattttat tgaatcaggc aagcaaagac cccatttact   3180

gttggccggg tttgggcgga tatcctatga gtttgagatt gcttgctaat aaagtcgttc   3240

ctgatcgggc attttatgga atacaggcat atgggataaa cgagagtgaa ataccgtttt   3300

cttctatcca gagaatggca gaagaggata ttaaagagat aaagaaaata cagccagaag   3360

ggccatatat attgtgggga tattcatttg gtgcccgagt agcatttgaa gttgcatacc   3420

agcttgaaca agcgggagaa gaagttaacg cattgaattt attggctccg ggatctcctc   3480

atcttgatat gaagcaagcg gaatatatgg ataaaggcgc tgaatttact aatccggctt   3540

ttgttaaaat acttttttct gtattttctc gttcaatcaa cagcccaatg gttaaaactt   3600

gcttagaaca agtaaatagt gaaacgacat ttattaactt tatatgtagt cgttttaaaa   3660

acttggaacc atcattagta aaacgtatcg ttaggattgt gactttgact tatgatttca   3720

agtacagtat tgatgagctt tatcacagac acctaaaggc acctataact attttcaagg   3780

cgaatagaga taatgattca tttatcgagg aatcggatgt gatttcatca atgtcgccta   3840

aaataattga attaatatcg gatcactatc aactgttgga aagtgaaggt gttgctgaga   3900

ttgagaaaat aatctaa                                                  3917


<210>  9
<211>  3917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered and functional indC from P. luminescens where we 
       replaced the native T-domain with a synthetic T-domain of our own
       design (variant 5)

<400>  9
atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa     60

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt    120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata    180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat    240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg    300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt    360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca    420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat    480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct    540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg    600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca    660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt    720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat    780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat    840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa    900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg    960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat   1020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat   1080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta   1140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt   1200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct   1260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt   1320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca   1380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta   1440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa   1500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta   1560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa   1620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa   1680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat   1740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa   1800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat   1860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca   1920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat   1980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg   2040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg   2100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag   2160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag   2220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat   2280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt   2340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc   2400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt   2460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta   2520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt   2580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa   2640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc   2700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat   2760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag   2820

cgtctattgg tgccattaca tacagatact gaatctcgtc tggcggacgt ttggggtcgt   2880

gcgctgaaat acgacgacgt ttctgcgcac gacgacttct tcgaatctgg tggtaactct   2940

ctgtctgcgg tttctctgat caacgaaatc aaccgtgcgt tcggtctgac cctgccgatc   3000

caggttgttt tccaggcgcc gaaagttcgt gaactggcgc ctttaatatt cgttttccgt   3060

tacagatact ttttcaatct cctaatatag cagaattggc taagtggatt gaacagacag   3120

actctaaaac aatatcaaga ttaattttat tgaatcaggc aagcaaagac cccatttact   3180

gttggccggg tttgggcgga tatcctatga gtttgagatt gcttgctaat aaagtcgttc   3240

ctgatcgggc attttatgga atacaggcat atgggataaa cgagagtgaa ataccgtttt   3300

cttctatcca gagaatggca gaagaggata ttaaagagat aaagaaaata cagccagaag   3360

ggccatatat attgtgggga tattcatttg gtgcccgagt agcatttgaa gttgcatacc   3420

agcttgaaca agcgggagaa gaagttaacg cattgaattt attggctccg ggatctcctc   3480

atcttgatat gaagcaagcg gaatatatgg ataaaggcgc tgaatttact aatccggctt   3540

ttgttaaaat acttttttct gtattttctc gttcaatcaa cagcccaatg gttaaaactt   3600

gcttagaaca agtaaatagt gaaacgacat ttattaactt tatatgtagt cgttttaaaa   3660

acttggaacc atcattagta aaacgtatcg ttaggattgt gactttgact tatgatttca   3720

agtacagtat tgatgagctt tatcacagac acctaaaggc acctataact attttcaagg   3780

cgaatagaga taatgattca tttatcgagg aatcggatgt gatttcatca atgtcgccta   3840

aaataattga attaatatcg gatcactatc aactgttgga aagtgaaggt gttgctgaga   3900

ttgagaaaat aatctaa                                                  3917


<210>  10
<211>  2751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene of unknown function from P. luminescens laumondii TT01; Pfam
       prediction suggests a single module NRPS with the domain sequence
       A-T-TE. We used the T-domain of this module to successfully 
       engineer the indC indigoidine synthetase

<400>  10
atgcaatcaa ctctcccaat aataaaatgg cgcaatatat taaaaacagg acagtatcga     60

aaatacgata tctccagcgc tcaaccggca aatgaaaatt ggataacgtt aaacaacatt    120

aagttaccag cgagttttca acgaaaagag tgcctaccgg gattactctt ttcacacgtc    180

agatcaactc cctgggctac agcagtcatt cacggtgaag agcaactcag ttatttggaa    240

atggcaattg gcagtgtaca tctggcctgc tatctgcaaa acctgggatg tttagcgggt    300

gattgcgtcg gtatatttgt tgaaccgtcg attgagcaga tgatcggagt ttggggaact    360

ctttttgccg gtggtgcata tctgccattg tctcatgatt atccagagga acgacttcgt    420

tacatgatcc acgatagcaa tctgaaaatg atatttaccc aagaaaaatt aaaggaaaaa    480

ttggtcaggt tggttgcaga aaatatccat atcgtgactc ttgaagacgt agagaaatca    540

tttgaatcca gtgccattac caacaacacc ctccatgact accttagccc agataacttg    600

gcttatgtca tttatacctc tggaagtaca gggaaaccga aaggtgtaat gattgagcac    660

cgcagtatcg ttaaccaaat gtgttggtta aatgaaaaat gcgatttaaa tattgaaaaa    720

acaattattc agaaaacgcc catcagcttt gatgctgctc aatgggaaat attatcagtc    780

agttgtggta gtcgggttgt tattagctca tctggaacac acaggaatat tccccaactc    840

attgacctga ttattcgcca caatgtgacc acgttacagt gtgttcccac gctattacaa    900

gcactgatcg ataatcatca attccgggaa tgccacaccc ttcggcaaat attcatcgga    960

gcagagagcc tatcaagaaa actcgccact caatgtatcc atacactacc aaactgtcta   1020

ctgattaata tgtatggccc ggcggaatgt acaattaatg cttcagtttt ccttgttaat   1080

cactacccaa tatctgacga agttaattca gtccctattg gtaagccggt atccaatacg   1140

gaatttttta ttctcgatca ccactatcag ctcgcctcag aatatgaaat tggagagatt   1200

tatattgcgg gcactcaagt cgcaagagga tatctgaatc gtcaggatct cacagaaaag   1260

cactttcttg aaattgcaat accaccaaat acgcaaaaaa tccggcttta tagaaccgga   1320

gacctggctt attgggataa agagggtaat gcccactttg ctggtcggaa agataatcaa   1380

attaaagtga gagggatgcg ggtcgaatta gaagaaataa aaaatgcaat agaggttatc   1440

gatcaagtga aacacgctgc aattttggca gaaaaagacc ctcaacaccg ttcgacacga   1500

ttaaccgcct gtattgaatt agccgatgaa acaatacgcc agcaagcaaa gtatgacatt   1560

acttcaattc tgcggagtga acttagcaaa acattaccgg actatatgtt acctgacaga   1620

tttttgttcc tggataccat gccgctaact tccagtggaa aaatcgattt cgacacatta   1680

caagtactgg tcagcacagt atcacacagt ccacaggtac tcccaagcac ctcgacagaa   1740

acacagatcg taaagatatg ggaagaagtg ctaacgcgag aaagcatatc taccgaagat   1800

gacttctttg ctttaggtgg caattctctg atagccgtcc atctgataca acgtttaaat   1860

gaagaatttg cgttatcgct acctctccat actctatttg aggccgcaac ggttaaacaa   1920

ttggcaaaaa tcgttgaagg tgaagtaacc agattatctt cacgattggc ctgtttacag   1980

gaaaaagatg ctggattacc tgtcttttgc tggccaggat tgggtggata cccaatgaat   2040

ttacacctgc tggctacaca gatctgcact gatcgatcat tttatggcat ccaagcttac   2100

ggaattaatg aaggagaggt tccatactcc accatagccg aaatggtgat tcaagacata   2160

acagaaatca aaaaattaca acctactggc ccatacacgc tatggggata ttcttttggc   2220

tctgtattgg ctttcgaagc ggcttaccaa ttagaacgag ccggagaaca tgtcgaaaag   2280

gtggttctaa tcgctccagg gctctcgaag ataaaatatc acgttaattc cacgggaaca   2340

gaaaacgggt ctacttacca aaacaatgag ttgatatcac tattattctc tgtatttgcg   2400

ggcacttctc acagttcagc gttgaatgaa tgcctggcta acgttatcga tgagcaaagc   2460

tttgtctctt ttgttcataa gcactaccca actctggccc ctacgttaat tgttcgaatt   2520

gccaggatag ttattcaaac ctacggacag aaatattcag caacagaact gcaagaacga   2580

ataatcaagg cgccaattac ggtgtttaat gcacgtgacg atgccgtttc ttttatcgaa   2640

gaagcaacac cctacctaaa acatccccca gaaaatatca atcttaacgt tgatcatttc   2700

gaggtactta aggaatcagg tgttaacgaa ttagctcgat tcttgagttg a            2751


<210>  11
<211>  6984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS being a synthetase of a fusion peptide consisting of 
       Asparagine and Indigoidine

<400>  11
atgcagacga acaaacaaca gacgttcagc gagctgctgc aaaccgtgca aaagcaagcc     60

ctggcgtctg ccacctacga tttcgcgccg ctgtacgaaa ttcagagcac aacagtgctg    120

aaacaggaat tgatcgatca tttggtcacg tttgaaaatt accccgatca ttcgatgaag    180

catctggaag aatcattagg gtttcaattc accgtagaaa gcggagatga gcagacctcc    240

tatgatttga acgtggtcgt cgccctcgct ccctcgaacg agctgtacgt gaagctaagc    300

tacaatgccg cggtgtatga atcgtcattc gtaaacagaa tcgaagggca tctccgcacc    360

gtcatcgacc aggtgatcgg caatccgcat gtacacctgc acgagatcgg catcatcacc    420

gaagaggaaa agcagcaact gctcgtcgcc tacaacgaca cggctgctga atatccgcgg    480

gacaaaacga ttttcgagct gatcgcggaa caagcgagcc ggacaccagc gaaagcagca    540

gttgtttgcg gcgaggacac cctgacctat caggagctga tggagcgttc tgcccagctt    600

gccaatgctt tgcgcgaaaa aggaatcgcc agcggcagca tcgtctcgat tatggcggaa    660

cattcactgg agctgatcgt ggcgatcatg gctgtcttgc ggtcaggtgc tgcctacttg    720

ccgattgatc ccgagtaccc gcaagatcgc atccagtatt tgctcgatga cagccagacc    780

acgctgctgt taacccagtc gcatctgcaa ccaaacatcc ggtttgcagg cagcgtgctt    840

tatttggacg atcgttcctt gtacgaaggc ggcagcacat ccttcgcacc cgagagcaag    900

cctgatgatt tggcgtacat gatctacact tccggttcta ccggcaatcc aaaaggggcg    960

atgattactc atcaaggcct ggtcaattac atctggtggg ccaacaaggt gtacgtccaa   1020

ggcgaagcgg tggactttcc gctgtactca tctatttcgt tcgatttgac cgtcacctcg   1080

atcttcacgc cgcttctgtc cggcaacacg attcatgtgt acagaggggc agacaaggta   1140

caggtcattt tggacatcat caaagataac aaagtcggga tcatcaagct gacgccgaca   1200

cacctgaagc tgattgaaca catcgacggc aaggccagca gcatcagacg gttcatcgtc   1260

ggcggcgaga acttgccgac aaagctggcg aagcaaatat acgaccattt cggagagaac   1320

gtgcaaattt tcaacgagta cggaccgacc gaaaccgttg tcggttgcat gatttacttg   1380

tatgacccgc aaacaacgac ccaggagtcg gtgccaatcg gtgtcccggc agacaacgtc   1440

cagctttatt tgctcgatgc ttccatgcag ccggtgcccg tcggctcgct tggcgaaatg   1500

tacatagccg gagacggcgt agccaaaggg tatttcaaca gaccggagct gacgaaggaa   1560

aagtttatcg acaacccgtt ccgtccggga accaaaatgt atcgaacagg cgacctggca   1620

aaatggctgc ctgatggaaa catggagtat gcaggcagaa tggactatca agtgaagatt   1680

cgcggccatc ggatcgagat gggcgaaatc gaaacgcgcc tgacgcagca tgaggcggtc   1740

aaggaagcgg tcgtgatcgt ggaaaaggat gagagcggcc aaaacgtgtt gtacgcgtac   1800

cttgtttccg agcgggaact gacggtagct gagctgagag aatttttggg gcgcacgctg   1860

ccttcctata tgattccttc cttctttatt cgcttggcgg aaattccgct gaccgcgaac   1920

ggaaaagtag agcgaaaaaa attgccgaag ccagctggcg cagtcgttac aggcaccgcg   1980

tatgcagctc cgcaaaatga aatcgaggca aagctggccg agatatggca gcaagtgctg   2040

ggcataagcc aggtagggat tcacgacgat ttctttgact tgggcggaca ctcgttgaag   2100

gcgatgactg tcgttttcca agtctcgaaa gcgctggaag tggaattgcc cgtaaaggcc   2160

ttgttcgaac atccaaccgt tgcggagctg gcccgcttcc tttcgcggtc ggaaaaaacc   2220

gagtacaccg cgattcaacc cgtggcagcg caggagtttt acccggtttc atctgcgcaa   2280

aaaagaatgt atatcctgca acagttcgaa ggcaacggaa tcagctacaa catttcgggt   2340

gcgattctcc tggaaggaaa gctggactac gcccggtttg ccagcgctgt gcaacagctg   2400

gcagagcgcc acgaagcttt gcgcacctcg ttccaccgga tcgacggcga gcctgtgcaa   2460

aaagtgcacg aggaagtaga agtgccgctt ttcatgctgg aggctcccga agaccaggcg   2520

gagaaaatca tgcgcgagtt tgtccgtccg tttgatctcg gggtcgctcc gctgatgcga   2580

acaggtttgc tcaagctggg caaagaccgc catttgtttt tgctcgacat gcaccatatc   2640

atctcggacg gcgtttcttc gcaaattttg ctgcgtgaat ttgccgagtt gtaccaggga   2700

gcagacttgc agccgctttc gctgcaatac aaagatttcg ctgcttggca aaatgagctg   2760

tttcagacgg aggcatacaa gaagcaggag cagcactggc tgaacacgtt tgctgatgaa   2820

attccgctct tgaacctgcc gactgactat ccgcgcccta gcgtgcaaag ctttgcaggc   2880

gatctcgtcc tttttgccgc cggaaaagaa ctgctggagc ggttgcaaca ggtagcgtca   2940

gaaacaggca ccaccttgta catgattttg cttgccgcct acaatgtgct gctgtccaag   3000

tataccggcc aggaagacat catcgtcggg acgcctgtcg ctggacgttc ccatgcggac   3060

gtggaaaaca tcatgggcat attcgtgaac acattggcgc tgcgcaacca gcctgccagc   3120

agcaaaacga tgttagaaaa taatattaca caatgtgact caatcaatga tgtttatctt   3180

aaagaagaag caataacatt gatggatatg cttgagagtc aacttaagca ccaggcagat   3240

ggatatgttg ttattgatca agaagaatct ctcagttacg ctgatttcta tttgagggtg   3300

aaagagatag ggtattgtct gtcagaaatt agctcaaaga attcggtggg tattgggctt   3360

ttttgtgatc cttctataga tttaatttgt ggtgcatggg gtattttgtc agcggataaa   3420

gcttatttgc cgttatcgcc tgactatcca actgaacgcc tcaaatatat gatagaagat   3480

tctggtattg atgtgatttt tacgcaatcg cacttaaaag cacagctaca ggacattgca   3540

ccaaaatcag tattaattat gacaccagaa gatgtcgctc tgacgataaa aacacgaaca   3600

atagaagata ttctgggcac agttcaagtt cctaaaccca ctagtctggc ttatattatt   3660

tatacctctg gtagcacggg taagccaaag ggagtgatga ttgaacatca cagtattgta   3720

aatcaaatga gatttcttgc aaaagcgttc aaattaggat gtcattcccg gattttacag   3780

aaaacaccaa tgagttttga tgcggctcaa tgggaaattc tagcgcctgc aattggtggt   3840

caagtgatta tgggtccttt aggttgctat cgcgatccgg atgcaattat taaaaccatt   3900

cttcagcatc aagtaacgac tttgcaatgt gttcctactt tgctacaagc gttactggat   3960

aatcctaatt ttttggattg cttatcattg actcaagtat tcagtggggg agaagcgctg   4020

acaaccaaat tagccacgca atttttgaat agttttactc actgtgaatt aatcaattta   4080

tatggcccga cagaatgtac gattaattca tcatttttcc gggtgacaaa tgagactttg   4140

ccgaattatc aaacctctat ttcgattggt gcacctgtag ataataccga atactacgtt   4200

cttgatgatg atagattacc tgtggcggtt ggcgaaattg gcgagcttta tatttcgggt   4260

gctcaattag cacgtggtta tttgcataaa ccagaaatga caaaagataa atttatttgt   4320

aatcaccttg tatcaggaac tcaacatcaa tggttatatc gaacgggaga tctggtaacc   4380

agaggggctg atggtaatac ttattttgtt ggtcgggttg atagccaggt caaattacga   4440

ggttaccgta ttgagcttga tgaaatacgc catgcgattg aagaacatag ctggataaag   4500

acggcggcaa tgttaattaa gaaggatgcc agaacgggtt tccaaaatct catcgcgtgt   4560

gtggaattag atgagaaaga agctgcattg atggatcaag gtaatagtag ctcacatcac   4620

aaatcaaaag ccgataaact acaggtgaaa gcccaacttt ctaattctgg ttgtcgaagt   4680

gaagagttat gtgaaaatcg ccctacattc ttacttcctt atcaagaagg ggagataaaa   4740

cagagagaat atgcatttgg acgcaagaca tatcgctatt ttgagggaac agaaataacg   4800

gtagagaaat taaaaaaatt gctgacagcc actcaatcga atgaaattag ctctttgcca   4860

ctgagtcatc taaccctgaa tgatttcggt tatgcattgc gttattttgg tcagtttacc   4920

agccatcaac gtttattgcc caaatatgcc tatgcttcac cgggtgctct ctatgcgaca   4980

caaatgtatt ttgaattgca taatgttctc ggtttggatg cggggattta ctattatcat   5040

ccagtgacac ataagttaat aaaaatttca acattgagtc gtcggcaaat gccaacgata   5100

aaagtgcatt ttattggcaa gcatgaagcc attgagcccg tttataagaa caatatacaa   5160

gaagttctgg aaatggaagc gggccatatg atgggtcttt ttgatgacgt attaccggaa   5220

attggcttga gtattggtaa aagtgaatat caagatgaat gtccagattg gtatgatggt   5280

gatattcagg attattatct tggtgcattt gaaatatgta gctatgaaca tggattgccg   5340

ccatttgaga ctgatattta tttacaaaca catgcccata aaatacctga gatgccgtgt   5400

ggtttatatc acttttctaa cggggaattt gtacgaataa gtgatgatat tgtccgaaaa   5460

aaggatgtta ttgcgattaa tcagcaagtt tatgatcgct ccagttttgg cgtgtcaatt   5520

attccacgct gtgtccctga atggcattat tatataacac tgggtcgtcg gttacatgcg   5580

ttacaaagta atccattgta tattggatta atgtcatctg gttacagttc gaagagcaat   5640

aacgatttac cttcggcgaa aaggatgcga tctattctca atgcacttga tagacctatg   5700

gcggcatttt atttctgcat aggtgggggt attagccaag cgcaatatat gtgtgaaggc   5760

atgaaagaag atgttgttca tatgaaaggg ccagttgaaa tcattaaaga tgatcttcaa   5820

caacaactcc ctcaatatat gattccaaat aaggtattag ttttcgataa attacctttg   5880

acggccaatg gaaaagtgga ttatcaatct ttatcagaat ctaaagccgt ggagaatgtt   5940

tcaacacagc gtctattggt gccattacat acagatactg aaataaggct tggaaaaatt   6000

tggatggaag tactgaaatg ggattcagta tctgccctcg atgatttttt cgaaagtggg   6060

ggtaattctt tgatggccgt tgcaatggtt aataagatca atgcggcctt taatattcgt   6120

tttccgttac agatactttt tcaatctcct aatatagcag aattggctaa gtggattgaa   6180

cagacagact ctaaaacaat atcaagatta attttattga atcaggcaag caaagacccc   6240

atttactgtt ggccgggttt gggcggatat cctatgagtt tgagattgct tgctaataaa   6300

gtcgttcctg atcgggcatt ttatggaata caggcatatg ggataaacga gagtgaaata   6360

ccgttttctt ctatccagag aatggcagaa gaggatatta aagagataaa gaaaatacag   6420

ccagaagggc catatatatt gtggggatat tcatttggtg cccgagtagc atttgaagtt   6480

gcataccagc ttgaacaagc gggagaagaa gttaacgcat tgaatttatt ggctccggga   6540

tctcctcatc ttgatatgaa gcaagcggaa tatatggata aaggcgctga atttactaat   6600

ccggcttttg ttaaaatact tttttctgta ttttctcgtt caatcaacag cccaatggtt   6660

aaaacttgct tagaacaagt aaatagtgaa acgacattta ttaactttat atgtagtcgt   6720

tttaaaaact tggaaccatc attagtaaaa cgtatcgtta ggattgtgac tttgacttat   6780

gatttcaagt acagtattga tgagctttat cacagacacc taaaggcacc tataactatt   6840

ttcaaggcga atagagataa tgattcattt atcgaggaat cggatgtgat ttcatcaatg   6900

tcgcctaaaa taattgaatt aatatcggat cactatcaac tgttggaaag tgaaggtgtt   6960

gctgagattg agaaaataat ctaa                                          6984


<210>  12
<211>  5450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct that enables easy cloning of NRPS modules in front of 
       Indigoidine module through the exchange of ccdB.

<400>  12
actggctgtg tataagggag cctgacattt atattcccca gaacatcagg ttaatggcgt     60

ttttgatgtc attttcgcgg tggctgagat cagccacttc ttccccgata acggagaccg    120

gcacactggc catatcggtg gtcatcatgc gccagctttc atccccgata tgcaccaccg    180

ggtaaagttc acgggagact ttatctgaca gcagacgtgc actggccagg gggatcacca    240

tccgtcgccc gggcgtgtca ataatatcac tctgtacatc cacaaacaga cgataacggc    300

tctctctttt ataggtgtaa accttaaact gcatttcacc agcccctgtt ctcgtcagca    360

aaagagccgt tcatttcaat aaaccgggcg acctcagcca tcccttcctg attttccgct    420

ttccagcgtt cggcacgcag acgacgggct tcattctgca tggttgtgct taccagaccg    480

gagatattga catcatatat gccttgagca actgatagct gtcgctgtca actgtcactg    540

taatacgctg cttcatagca tacctctttt tgacatactt cgggtataca tatcagtata    600

tattcttata ccgcaaaaat cagcgcgcaa atacgcatac tgttatctgg cttttagtaa    660

gccggatcca cgcgtcggaa aaaaccgagt acaccgcgat tcaacccgtg gcagcgcagg    720

agttttaccc ggtttcatct gcgcaaaaaa gaatgtatat cctgcaacag ttcgaaggca    780

acggaatcag ctacaacatt tcgggtgcga ttctcctgga aggaaagctg gactacgccc    840

ggtttgccag cgctgtgcaa cagctggcag agcgccacga agctttgcgc acctcgttcc    900

accggatcga cggcgagcct gtgcaaaaag tgcacgagga agtagaagtg ccgcttttca    960

tgctggaggc tcccgaagac caggcggaga aaatcatgcg cgagtttgtc cgtccgtttg   1020

atctcggggt cgctccgctg atgcgaacag gtttgctcaa gctgggcaaa gaccgccatt   1080

tgtttttgct cgacatgcac catatcatct cggacggcgt ttcttcgcaa attttgctgc   1140

gtgaatttgc cgagttgtac cagggagcag acttgcagcc gctttcgctg caatacaaag   1200

atttcgctgc ttggcaaaat gagctgtttc agacggaggc atacaagaag caggagcagc   1260

actggctgaa cacgtttgct gatgaaattc cgctcttgaa cctgccgact gactatccgc   1320

gccctagcgt gcaaagcttt gcaggcgatc tcgtcctttt tgccgccgga aaagaactgc   1380

tggagcggtt gcaacaggta gcgtcagaaa caggcaccac cttgtacatg attttgcttg   1440

ccgcctacaa tgtgctgctg tccaagtata ccggccagga agacatcatc gtcgggacgc   1500

ctgtcgctgg acgttcccat gcggacgtgg aaaacatcat gggcatattc gtgaacacat   1560

tggcgctgcg caaccagcct gccagcagca aaacgatgtt agaaaataat attacacaat   1620

gtgactcaat caatgatgtt tatcttaaag aagaagcaat aacattgatg gatatgcttg   1680

agagtcaact taagcaccag gcagatggat atgttgttat tgatcaagaa gaatctctca   1740

gttacgctga tttctatttg agggtgaaag agatagggta ttgtctgtca gaaattagct   1800

caaagagttc ggtgggtatt gggctttttt gtgatccttc tatagattta atttgtggtg   1860

catggggtat tttgtcagcg gataaagctt atttgccgtt atcgcctgac tatccaactg   1920

aacgcctcaa atatatgata gaagattctg gtattgatgt gatttttacg caatcgcact   1980

taaaagcaca gctacaggac attgcaccaa aatcagtatt aattatgaca ccagaagatg   2040

tcgctctgac gataaaaaca cgaacaatag aagatattct gggcacagtt caagttccta   2100

aacccacgag tctggcttat attatttata cctctggtag cacgggtaag ccaaagggag   2160

tgatgattga acatcacagt attgtaaatc aaatgagatt tcttgcaaaa gcgttcaaat   2220

taggatgtca ttcccggatt ttacagaaaa caccaatgag ttttgatgcg gctcaatggg   2280

aaattctagc gcctgcaatt ggtggtcaag tgattatggg tcctttaggt tgctatcgcg   2340

atccggatgc aattattaaa accattcttc agcatcaagt aacgactttg caatgtgttc   2400

ctactttgct acaagcgtta ctggataatc ctaatttttt ggattgctta tcattgactc   2460

aagtattcag tgggggagaa gcgctgacaa ccaaattagc cacgcaattt ttgaatagtt   2520

ttactcactg tgaattaatc aatttatatg gcccgacaga atgtacgatt aattcatcat   2580

ttttccgggt gacaaatgag actttgccga attatcaaac ctctatttcg attggtgcac   2640

ctgtagataa taccgaatac tacgttcttg atgatgatag attacctgtg gcggttggcg   2700

aaattggcga gctttatatt tcgggtgctc aattagcacg tggttatttg cataaaccag   2760

aaatgacaaa agataaattt atttgtaatc accttgtatc aggaactcaa catcaatggt   2820

tatatcgaac gggagatctg gtaaccagag gggctgatgg taatacttat tttgttggtc   2880

gggttgatag ccaggtcaaa ttacgaggtt accgtattga gcttgatgaa atacgccatg   2940

cgattgaaga acatagctgg ataaagacgg cggcaatgtt aattaagaag gatgccagaa   3000

cgggtttcca aaatctcatc gcgtgtgtgg aattagatga gaaagaagct gcattgatgg   3060

atcaaggtaa tagtagctca catcacaaat caaaagccga taaactacag gtgaaagccc   3120

aactttctaa ttctggttgt cgaagtgaag agttatgtga aaatcgccct acattcttac   3180

ttccttatca agaaggggag ataaaacaga gagaatatgc atttggacgc aagacatatc   3240

gctattttga gggaacagaa ataacggtag agaaattaaa aaaattgctg acagccactc   3300

aatcgaatga aattagctct ttgccactga gtcatctaac cctgaatgat ttcggttatg   3360

cattgcgtta ttttggtcag tttaccagcc atcaacgttt attgcccaaa tatgcctatg   3420

cttcaccggg tgctctctat gcgacacaaa tgtattttga attgcataat gttctcggtt   3480

tggatgcggg gatttactat tatcatccag tgacacataa gttaataaaa atttcaacat   3540

tgagtcgtcg gcaaatgcca acgataaaag tgcattttat tggcaagcat gaagccattg   3600

agcccgttta taagaacaat atacaagaag ttctggaaat ggaagcgggc catatgatgg   3660

gtctttttga tgacgtatta ccggaaattg gcttgagtat tggtaaaagt gaatatcaag   3720

atgaatgtcc agattggtat gatggtgata ttcaggatta ttatcttggt gcatttgaaa   3780

tatgtagcta tgaacatgga ttgccgccat ttgagactga tatttattta caaacacatg   3840

cccataaaat acctgagatg ccgtgtggtt tatatcactt ttctaacggg gaatttgtac   3900

gaataagtga tgatattgtc cgaaaaaagg atgttattgc gattaatcag caagtttatg   3960

atcgctccag ttttggcgtg tcaattattc cacgctgtgt ccctgaatgg cattattata   4020

taacactggg tcgtcggtta catgcgttac aaagtaatcc attgtatatt ggattaatgt   4080

catctggtta cagttcgaag agcaataacg atttaccttc ggcgaaaagg atgcgatcta   4140

ttctcaatgc acttgataga cctatggcgg cattttattt ctgcataggt gggggtatta   4200

gccaagcgca atatatgtgt gaaggcatga aagaagatgt tgttcatatg aaagggccag   4260

ttgaaatcat taaagatgat cttcaacaac aactccctca atatatgatt ccaaataagg   4320

tattagtttt cgataaatta cctttgacgg ccaatggaaa agtggattat caatctttat   4380

cagaatctaa agccgtggag aatgtttcaa cacagcgtct attggtgcca ttacatacag   4440

atactgaaat aaggcttgga aaaatttgga tggaagtact gaaatgggat tcagtatctg   4500

ccctcgatga ttttttcgaa agtgggggta attctttgat ggccgttgca atggttaata   4560

agatcaatgc ggcctttaat attcgttttc cgttacagat actttttcaa tctcctaata   4620

tagcagaatt ggctaagtgg attgaacaga cagactctaa aacaatatca agattaattt   4680

tattgaatca ggcaagcaaa gaccccattt actgttggcc gggtttgggc ggatatccta   4740

tgagtttgag attgcttgct aataaagtcg ttcctgatcg ggcattttat ggaatacagg   4800

catatgggat aaacgagagt gaaataccgt tttcttctat ccagagaatg gcagaagagg   4860

atattaaaga gataaagaaa atacagccag aagggccata tatattgtgg ggatattcat   4920

ttggtgcccg agtagcattt gaagttgcat accagcttga acaagcggga gaagaagtta   4980

acgcattgaa tttattggct ccgggatctc ctcatcttga tatgaagcaa gcggaatata   5040

tggataaagg cgctgaattt actaatccgg cttttgttaa aatacttttt tctgtatttt   5100

ctcgttcaat caacagccca atggttaaaa cttgcttaga acaagtaaat agtgaaacga   5160

catttattaa ctttatatgt agtcgtttta aaaacttgga accatcatta gtaaaacgta   5220

tcgttaggat tgtgactttg acttatgatt tcaagtacag tattgatgag ctttatcaca   5280

gacacctaaa ggcacctata actattttca aggcgaatag agataatgat tcatttatcg   5340

aggaatcgga tgtgatttca tcaatgtcgc ctaaaataat tgaattaata tcggatcact   5400

atcaactgtt ggaaagtgaa ggtgttgctg agattgagaa aataatctaa              5450


<210>  13
<211>  9666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Indigoidine-tagged Dipeptide consisting of 
       Ornithine and Valine

<400>  13
atgctgcaca gcttcctcgc aaccaaaaca gcctatccga cggacaaaac gttccagaag     60

ctgttcgagg agcaagtgga aaaaacaccg aacgagattg ccgttctgtt cggcaatgaa    120

cagctgacct atcaggagtt gaatgcaaaa gcaaaccagc tcgcccgcgt cctgcggcga    180

aaaggcgtca agccggagag caccgtcggc atcctcgtag accgctcgct ctacatggtc    240

atcggcatgc tggccgtgtt gaaagcaggc ggaacattcg tcccgattga tccggactac    300

ccgctggagc gccaagcgtt catgctcgaa gacagcgagg cgaagctgct gctcaccttg    360

caaaaaatga acagtcaagt tgccttccct tatgaaacct tttatctgga tacagagaca    420

gtggatcagg aggagacggg caatctggag cacgttgcgc agccggagaa cgtcgcttac    480

atcatctaca catccggtac gacgggcaag ccaaaagggg tcgtcatcga gcaccgcagc    540

tatgccaatg tcgcatttgc ctggaaagac gaatatcacc tggacagctt cccggtccgt    600

ttgctgcaaa tggcgagctt cgcctttgac gtctcgacgg gcgattttgc cagggcgctg    660

ctgacaggcg ggcaactggt catctgcccg aatggggtca aaatggaccc agcttcgctg    720

tacgagacca tcaggcgtca cgaaattacc attttcgaag cgacacccgc cttgatcatg    780

ccgttgatgc actacgttta cgaaaacgaa ctggatatga gccaaatgaa gctgctgatt    840

ctcggagcag acagctgccc ggcggaagac ttcaaaacgt tgctcgcgcg cttcggtcag    900

aagatgcgca ttatcaacag ctacggcgtg acagaggcgt gcattgacac cagctactac    960

gaagaaacag acgtcaccgc catccgctcg ggaacggtgc cgatcggcaa accgcttccg   1020

aacatgacga tgtacgtggt cgatgcgcat ttgaatttgc agcctgtcgg cgtcgtaggc   1080

gaattgtgca tcggcggagc aggggttgcg cgcggttatt tgaacagacc tgagctgacg   1140

gaagagaagt tcgtgccgaa tccgttcgcc ccaggtgaac gattgtaccg cacaggtgat   1200

ctggcgaagt ggcgcgcaga tggcaatgtc gagttcctcg gacgcaatga ccaccaggta   1260

aaaatcaggg gtgtccgcat cgagctgggc gagatcgaga cacaactgcg caagctggac   1320

ggaattacgg aagcagtcgt ggttgcgaga gaagatcgcg ggcaggaaaa ggaattgtgc   1380

gcatacgtcg tggcggacca caagcttgac accgcagaat tgcgggcgaa tttgctgaag   1440

gaactgccgc aagcgatgat tccagcgtat ttcgtcacct tggatgcgct gccgctgact   1500

gccaatggca aagtagacag acgttccttg ccagcgccgg atgtcaccat gctgagaacg   1560

accgagtatg tagcgccgcg ctccgtctgg gaagcccgat tggcccaagt atgggagcag   1620

gtgctgaatg ttccgcaagt gggtgcgcta gacgactttt tcgcgctcgg cggtcactca   1680

ttgcgtgcca tgcgcgtcct ttccagcatg cacaacgaat accaggtcga catcccgctg   1740

cgcatcttgt tcgaaaaacc gacgattcag gaactggcgg cgttcatcga aacgagcgga   1800

aaagagacgt atgtgccgat cgagcctgca ccgttgcaag agtattatcc tgtttcatct   1860

gcgcaaaagc ggatgtatgt cctgcgccag tttgcggaca caggcacggt ttataacatg   1920

ccgagcgcgt tgtatatcga aggcgatctg gatcggaagc gttttgaagc cgccatccac   1980

ggattggtcg agcggcacga atcgctgcgc acatccttcc acaccgtaaa tggcgagcct   2040

gtccagcgcg tacacgagca tgtcgagctg aatgtgcagt acgcggaagt gacggaagcg   2100

caagtggagc caaccgtcga gtcgttcgtg caagcatttg atctgacaaa agctccgcta   2160

ttgcgggtcg gacttttcaa gctggcagcg aaacggcatc tgttcctgct ggatatgcat   2220

cacatcatct cggatggcgt ctcggccgga atcattatgg aagagttctc gaagctgtat   2280

cgaggcgaag aactgcctgc gctttccgtc cattacaaag atttcgccgt ctggcagtct   2340

gaactgttcc agagcgacgt ctataccgag catgaaaact actggctgaa cgcgttttct   2400

ggcgacattc cggtgcttaa cttgccagcc gatttttctc gtccgctgac acagagcttt   2460

gaaggagatt gcgtttcgtt ccaggcagac aaagcgttgc tggacgatct tcacaagctc   2520

gctcaggaga gccaatcgac gttgttcatg gtattgctgg cggcttacaa tgtgctgctt   2580

gccaagtaca gcggacagga agacatcgtc gtcggcacac cgattgcggg cagatcgcac   2640

gccgatatcg agaacgttct ggggatgttt gtcaacacgc tcgctttgcg caactatccg   2700

gtcgagacga aacacttcca ggcatttttg gaagaggtca agcaaaatac gctgcaagca   2760

tacgcccatc aagattatcc gttcgaagca ctggtcgaaa agctggacat ccagcgggat   2820

ctcagccgca atccgctgtt tgacaccatg tttattttgc aaaacctgga ccaaaaagct   2880

tacgagctgg atgggctgaa actggaggca tatccggcac aagcaggcaa cgccaaattc   2940

gatctcacgc tggaagcgca cgaggacgag acaggcattc attttgcgct cgtctactcg   3000

accaaattgt tccagcgaga atcaatcgaa agaatggcgg gtcacttcct gcaagtgctg   3060

cgccaagtcg ttgccgacca agcaactgcc ttgcgcgaga tcagcctgct cagcgaggaa   3120

gagcgccgaa ttgtgaccgt tgatttcaac aacacgtttg cctatccgcg cgatctgacg   3180

attcaggagc tgttcgagca gcaggcagca aaaactccgg agcatgcagc ggtcgtgatg   3240

gacggacaga tgctgacgta tcgggagctg aacgaaaaag cgaaccagct cgcccatgtc   3300

cttcgtcaaa acggagtcgg gaaagagagc atcgtcggtc tgctcgcaga tcgttcgctg   3360

gaaatgatta caggcatcat ggggattctc aaagcgggcg gcgcctacct gggactggac   3420

ccggagcatc cgtccgaacg cctggcttac atgttggaag atggcggcgt gaaagttgtc   3480

ctcgtgcaaa agcacttgct gccgctcgtc ggcgaagggc tgatgccaat cgttttggaa   3540

gaggagagcc tgcgcccgga agattgcggc aatccggcga ttgtcaacgg tgcgagtgac   3600

ctggcttatg tgatgtacac ctcaggctct acaggcaagc caaaaggagt catggtcgag   3660

catcgcaacg tcacccgctt ggtcatgcat acgaattacg tgcaagtgcg cgagagcgac   3720

cggatgattc aaaccggcgc gattggcttc gacgccatga catttgagat ttttggagcc   3780

ttgctgcacg gggccagcct gtatttggtg agcaaggacg tcttgctgga tgccgaaaag   3840

ctgggcgact tcctgcggac gaatcagatt acgaccatgt ggctgacctc gccgctcttc   3900

aaccagcttt cgcaagacaa tccggcgatg tttgacagct tgcgcgcctt gatcgtcggt   3960

ggcgaagcgt tgtcgccgaa gcacatcaac cgggtaaaaa gtgcccttcc tgacctggaa   4020

atctggaacg gatacggccc gaccgaaaac acgaccttct cgacgtgcta tttgattgag   4080

cagcattttg aagagcagat tccgatcggc aagccgattg caaactccac cgcgtatatc   4140

gtcgacggca acaatcagcc gcagccgatc ggcgtaccgg gtgaactgtg cgtcggtggt   4200

gacggtgtcg caagaggcta tgtgaacaag ccggaattaa ccgccgaaaa gtttgtgccc   4260

aatccgtttg cgcctggcga aacgatgtat cgcaccggag atttggcgag atggctgccg   4320

gatgggacga ttgagtattt gggccgaatc gaccagcagg tcaaaatcag gggataccgg   4380

atcgagcttg gggaaatcga gacggtcttg tcccagcagg cacaagtaaa agaagcagtc   4440

gtggccgtga tcgaggaggc gaacgggcaa aaagctctct gcgcttactt tgtgccagaa   4500

caggccgtcg acgccgcaga gctgcgagaa gcgatgtcca aacaattgcc tggctacatg   4560

gtccctgctt actatgtgca aatggaaaag ctgccgttga ccgcgaacgg aaaggtcgac   4620

cgccgggcat tgccgcagcc atccggcgag cggacgacag gaagcgcctt tgtcgctgcg   4680

caaaatgata ccgaagcgaa gctgcaacag atttggcaag aagttttggg cattccggca   4740

atcggcattc acgacaactt ctttgaaatc ggcggtcatt ccttgaaggc gatgaacgtc   4800

atcacgcaag tccataaaac attccaggtg gagctgccgt taaaagcgct gtttgccact   4860

ccgacgatcc atgagttggc tgcgcatatt tcggaaaaaa ccgagtacac cgcgattcaa   4920

cccgtggcag cgcaggagtt ttacccggtt tcatctgcgc aaaaaagaat gtatatcctg   4980

caacagttcg aaggcaacgg aatcagctac aacatttcgg gtgcgattct cctggaagga   5040

aagctggact acgcccggtt tgccagcgct gtgcaacagc tggcagagcg ccacgaagct   5100

ttgcgcacct cgttccaccg gatcgacggc gagcctgtgc aaaaagtgca cgaggaagta   5160

gaagtgccgc ttttcatgct ggaggctccc gaagaccagg cggagaaaat catgcgcgag   5220

tttgtccgtc cgtttgatct cggggtcgct ccgctgatgc gaacaggttt gctcaagctg   5280

ggcaaagacc gccatttgtt tttgctcgac atgcaccata tcatctcgga cggcgtttct   5340

tcgcaaattt tgctgcgtga atttgccgag ttgtaccagg gagcagactt gcagccgctt   5400

tcgctgcaat acaaagattt cgctgcttgg caaaatgagc tgtttcagac ggaggcatac   5460

aagaagcagg agcagcactg gctgaacacg tttgctgatg aaattccgct cttgaacctg   5520

ccgactgact atccgcgccc tagcgtgcaa agctttgcag gcgatctcgt cctttttgcc   5580

gccggaaaag aactgctgga gcggttgcaa caggtagcgt cagaaacagg caccaccttg   5640

tacatgattt tgcttgccgc ctacaatgtg ctgctgtcca agtataccgg ccaggaagac   5700

atcatcgtcg ggacgcctgt cgctggacgt tcccatgcgg acgtggaaaa catcatgggc   5760

atattcgtga acacattggc gctgcgcaac cagcctgcca gcagcaaaac gatgttagaa   5820

aataatatta cacaatgtga ctcaatcaat gatgtttatc ttaaagaaga agcaataaca   5880

ttgatggata tgcttgagag tcaacttaag caccaggcag atggatatgt tgttattgat   5940

caagaagaat ctctcagtta cgctgatttc tatttgaggg tgaaagagat agggtattgt   6000

ctgtcagaaa ttagctcaaa gaattcggtg ggtattgggc ttttttgtga tccttctata   6060

gatttaattt gtggtgcatg gggtattttg tcagcggata aagcttattt gccgttatcg   6120

cctgactatc caactgaacg cctcaaatat atgatagaag attctggtat tgatgtgatt   6180

tttacgcaat cgcacttaaa agcacagcta caggacattg caccaaaatc agtattaatt   6240

atgacaccag aagatgtcgc tctgacgata aaaacacgaa caatagaaga tattctgggc   6300

acagttcaag ttcctaaacc cactagtctg gcttatatta tttatacctc tggtagcacg   6360

ggtaagccaa agggagtgat gattgaacat cacagtattg taaatcaaat gagatttctt   6420

gcaaaagcgt tcaaattagg atgtcattcc cggattttac agaaaacacc aatgagtttt   6480

gatgcggctc aatgggaaat tctagcgcct gcaattggtg gtcaagtgat tatgggtcct   6540

ttaggttgct atcgcgatcc ggatgcaatt attaaaacca ttcttcagca tcaagtaacg   6600

actttgcaat gtgttcctac tttgctacaa gcgttactgg ataatcctaa ttttttggat   6660

tgcttatcat tgactcaagt attcagtggg ggagaagcgc tgacaaccaa attagccacg   6720

caatttttga atagttttac tcactgtgaa ttaatcaatt tatatggccc gacagaatgt   6780

acgattaatt catcattttt ccgggtgaca aatgagactt tgccgaatta tcaaacctct   6840

atttcgattg gtgcacctgt agataatacc gaatactacg ttcttgatga tgatagatta   6900

cctgtggcgg ttggcgaaat tggcgagctt tatatttcgg gtgctcaatt agcacgtggt   6960

tatttgcata aaccagaaat gacaaaagat aaatttattt gtaatcacct tgtatcagga   7020

actcaacatc aatggttata tcgaacggga gatctggtaa ccagaggggc tgatggtaat   7080

acttattttg ttggtcgggt tgatagccag gtcaaattac gaggttaccg tattgagctt   7140

gatgaaatac gccatgcgat tgaagaacat agctggataa agacggcggc aatgttaatt   7200

aagaaggatg ccagaacggg tttccaaaat ctcatcgcgt gtgtggaatt agatgagaaa   7260

gaagctgcat tgatggatca aggtaatagt agctcacatc acaaatcaaa agccgataaa   7320

ctacaggtga aagcccaact ttctaattct ggttgtcgaa gtgaagagtt atgtgaaaat   7380

cgccctacat tcttacttcc ttatcaagaa ggggagataa aacagagaga atatgcattt   7440

ggacgcaaga catatcgcta ttttgaggga acagaaataa cggtagagaa attaaaaaaa   7500

ttgctgacag ccactcaatc gaatgaaatt agctctttgc cactgagtca tctaaccctg   7560

aatgatttcg gttatgcatt gcgttatttt ggtcagttta ccagccatca acgtttattg   7620

cccaaatatg cctatgcttc accgggtgct ctctatgcga cacaaatgta ttttgaattg   7680

cataatgttc tcggtttgga tgcggggatt tactattatc atccagtgac acataagtta   7740

ataaaaattt caacattgag tcgtcggcaa atgccaacga taaaagtgca ttttattggc   7800

aagcatgaag ccattgagcc cgtttataag aacaatatac aagaagttct ggaaatggaa   7860

gcgggccata tgatgggtct ttttgatgac gtattaccgg aaattggctt gagtattggt   7920

aaaagtgaat atcaagatga atgtccagat tggtatgatg gtgatattca ggattattat   7980

cttggtgcat ttgaaatatg tagctatgaa catggattgc cgccatttga gactgatatt   8040

tatttacaaa cacatgccca taaaatacct gagatgccgt gtggtttata tcacttttct   8100

aacggggaat ttgtacgaat aagtgatgat attgtccgaa aaaaggatgt tattgcgatt   8160

aatcagcaag tttatgatcg ctccagtttt ggcgtgtcaa ttattccacg ctgtgtccct   8220

gaatggcatt attatataac actgggtcgt cggttacatg cgttacaaag taatccattg   8280

tatattggat taatgtcatc tggttacagt tcgaagagca ataacgattt accttcggcg   8340

aaaaggatgc gatctattct caatgcactt gatagaccta tggcggcatt ttatttctgc   8400

ataggtgggg gtattagcca agcgcaatat atgtgtgaag gcatgaaaga agatgttgtt   8460

catatgaaag ggccagttga aatcattaaa gatgatcttc aacaacaact ccctcaatat   8520

atgattccaa ataaggtatt agttttcgat aaattacctt tgacggccaa tggaaaagtg   8580

gattatcaat ctttatcaga atctaaagcc gtggagaatg tttcaacaca gcgtctattg   8640

gtgccattac atacagatac tgaaataagg cttggaaaaa tttggatgga agtactgaaa   8700

tgggattcag tatctgccct cgatgatttt ttcgaaagtg ggggtaattc tttgatggcc   8760

gttgcaatgg ttaataagat caatgcggcc tttaatattc gttttccgtt acagatactt   8820

tttcaatctc ctaatatagc agaattggct aagtggattg aacagacaga ctctaaaaca   8880

atatcaagat taattttatt gaatcaggca agcaaagacc ccatttactg ttggccgggt   8940

ttgggcggat atcctatgag tttgagattg cttgctaata aagtcgttcc tgatcgggca   9000

ttttatggaa tacaggcata tgggataaac gagagtgaaa taccgttttc ttctatccag   9060

agaatggcag aagaggatat taaagagata aagaaaatac agccagaagg gccatatata   9120

ttgtggggat attcatttgg tgcccgagta gcatttgaag ttgcatacca gcttgaacaa   9180

gcgggagaag aagttaacgc attgaattta ttggctccgg gatctcctca tcttgatatg   9240

aagcaagcgg aatatatgga taaaggcgct gaatttacta atccggcttt tgttaaaata   9300

cttttttctg tattttctcg ttcaatcaac agcccaatgg ttaaaacttg cttagaacaa   9360

gtaaatagtg aaacgacatt tattaacttt atatgtagtc gttttaaaaa cttggaacca   9420

tcattagtaa aacgtatcgt taggattgtg actttgactt atgatttcaa gtacagtatt   9480

gatgagcttt atcacagaca cctaaaggca cctataacta ttttcaaggc gaatagagat   9540

aatgattcat ttatcgagga atcggatgtg atttcatcaa tgtcgcctaa aataattgaa   9600

ttaatatcgg atcactatca actgttggaa agtgaaggtg ttgctgagat tgagaaaata   9660

atctaa                                                              9666


<210>  14
<211>  12771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Indigoidine-tagged Tripeptide consisting of 
       Ornithine and two Valines

<400>  14
atgctgcaca gcttcctcgc aaccaaaaca gcctatccga cggacaaaac gttccagaag     60

ctgttcgagg agcaagtgga aaaaacaccg aacgagattg ccgttctgtt cggcaatgaa    120

cagctgacct atcaggagtt gaatgcaaaa gcaaaccagc tcgcccgcgt cctgcggcga    180

aaaggcgtca agccggagag caccgtcggc atcctcgtag accgctcgct ctacatggtc    240

atcggcatgc tggccgtgtt gaaagcaggc ggaacattcg tcccgattga tccggactac    300

ccgctggagc gccaagcgtt catgctcgaa gacagcgagg cgaagctgct gctcaccttg    360

caaaaaatga acagtcaagt tgccttccct tatgaaacct tttatctgga tacagagaca    420

gtggatcagg aggagacggg caatctggag cacgttgcgc agccggagaa cgtcgcttac    480

atcatctaca catccggtac gacgggcaag ccaaaagggg tcgtcatcga gcaccgcagc    540

tatgccaatg tcgcatttgc ctggaaagac gaatatcacc tggacagctt cccggtccgt    600

ttgctgcaaa tggcgagctt cgcctttgac gtctcgacgg gcgattttgc cagggcgctg    660

ctgacaggcg ggcaactggt catctgcccg aatggggtca aaatggaccc agcttcgctg    720

tacgagacca tcaggcgtca cgaaattacc attttcgaag cgacacccgc cttgatcatg    780

ccgttgatgc actacgttta cgaaaacgaa ctggatatga gccaaatgaa gctgctgatt    840

ctcggagcag acagctgccc ggcggaagac ttcaaaacgt tgctcgcgcg cttcggtcag    900

aagatgcgca ttatcaacag ctacggcgtg acagaggcgt gcattgacac cagctactac    960

gaagaaacag acgtcaccgc catccgctcg ggaacggtgc cgatcggcaa accgcttccg   1020

aacatgacga tgtacgtggt cgatgcgcat ttgaatttgc agcctgtcgg cgtcgtaggc   1080

gaattgtgca tcggcggagc aggggttgcg cgcggttatt tgaacagacc tgagctgacg   1140

gaagagaagt tcgtgccgaa tccgttcgcc ccaggtgaac gattgtaccg cacaggtgat   1200

ctggcgaagt ggcgcgcaga tggcaatgtc gagttcctcg gacgcaatga ccaccaggta   1260

aaaatcaggg gtgtccgcat cgagctgggc gagatcgaga cacaactgcg caagctggac   1320

ggaattacgg aagcagtcgt ggttgcgaga gaagatcgcg ggcaggaaaa ggaattgtgc   1380

gcatacgtcg tggcggacca caagcttgac accgcagaat tgcgggcgaa tttgctgaag   1440

gaactgccgc aagcgatgat tccagcgtat ttcgtcacct tggatgcgct gccgctgact   1500

gccaatggca aagtagacag acgttccttg ccagcgccgg atgtcaccat gctgagaacg   1560

accgagtatg tagcgccgcg ctccgtctgg gaagcccgat tggcccaagt atgggagcag   1620

gtgctgaatg ttccgcaagt gggtgcgcta gacgactttt tcgcgctcgg cggtcactca   1680

ttgcgtgcca tgcgcgtcct ttccagcatg cacaacgaat accaggtcga catcccgctg   1740

cgcatcttgt tcgaaaaacc gacgattcag gaactggcgg cgttcatcga aacgagcgga   1800

aaagagacgt atgtgccgat cgagcctgca ccgttgcaag agtattatcc tgtttcatct   1860

gcgcaaaagc ggatgtatgt cctgcgccag tttgcggaca caggcacggt ttataacatg   1920

ccgagcgcgt tgtatatcga aggcgatctg gatcggaagc gttttgaagc cgccatccac   1980

ggattggtcg agcggcacga atcgctgcgc acatccttcc acaccgtaaa tggcgagcct   2040

gtccagcgcg tacacgagca tgtcgagctg aatgtgcagt acgcggaagt gacggaagcg   2100

caagtggagc caaccgtcga gtcgttcgtg caagcatttg atctgacaaa agctccgcta   2160

ttgcgggtcg gacttttcaa gctggcagcg aaacggcatc tgttcctgct ggatatgcat   2220

cacatcatct cggatggcgt ctcggccgga atcattatgg aagagttctc gaagctgtat   2280

cgaggcgaag aactgcctgc gctttccgtc cattacaaag atttcgccgt ctggcagtct   2340

gaactgttcc agagcgacgt ctataccgag catgaaaact actggctgaa cgcgttttct   2400

ggcgacattc cggtgcttaa cttgccagcc gatttttctc gtccgctgac acagagcttt   2460

gaaggagatt gcgtttcgtt ccaggcagac aaagcgttgc tggacgatct tcacaagctc   2520

gctcaggaga gccaatcgac gttgttcatg gtattgctgg cggcttacaa tgtgctgctt   2580

gccaagtaca gcggacagga agacatcgtc gtcggcacac cgattgcggg cagatcgcac   2640

gccgatatcg agaacgttct ggggatgttt gtcaacacgc tcgctttgcg caactatccg   2700

gtcgagacga aacacttcca ggcatttttg gaagaggtca agcaaaatac gctgcaagca   2760

tacgcccatc aagattatcc gttcgaagca ctggtcgaaa agctggacat ccagcgggat   2820

ctcagccgca atccgctgtt tgacaccatg tttattttgc aaaacctgga ccaaaaagct   2880

tacgagctgg atgggctgaa actggaggca tatccggcac aagcaggcaa cgccaaattc   2940

gatctcacgc tggaagcgca cgaggacgag acaggcattc attttgcgct cgtctactcg   3000

accaaattgt tccagcgaga atcaatcgaa agaatggcgg gtcacttcct gcaagtgctg   3060

cgccaagtcg ttgccgacca agcaactgcc ttgcgcgaga tcagcctgct cagcgaggaa   3120

gagcgccgaa ttgtgaccgt tgatttcaac aacacgtttg ccgcgtatcc gcgcgatctg   3180

acgattcagg agctgttcga gcagcaggca gcaaaaactc cggagcatgc agcggtcgtg   3240

atggacggac agatgctgac gtatcgggag ctgaacgaaa aagcgaacca gctcgcccat   3300

gtccttcgtc aaaacggagt cgggaaagag agcatcgtcg gtctgctcgc agatcgttcg   3360

ctggaaatga ttacaggcat catggggatt ctcaaagcgg gcggcgccta cctgggactg   3420

gacccggagc atccgtccga acgcctggct tacatgttgg aagatggcgg cgtgaaagtt   3480

gtcctcgtgc aaaagcactt gctgccgctc gtcggcgaag ggctgatgcc aatcgttttg   3540

gaagaggaga gcctgcgccc ggaagattgc ggcaatccgg cgattgtcaa cggtgcgagt   3600

gacctggctt atgtgatgta cacctcaggc tctacaggca agccaaaagg agtcatggtc   3660

gagcatcgca acgtcacccg cttggtcatg catacgaatt acgtgcaagt gcgcgagagc   3720

gaccggatga ttcaaaccgg cgcgattggc ttcgacgcca tgacatttga gatttttgga   3780

gccttgctgc acggggccag cctgtatttg gtgagcaagg acgtcttgct ggatgccgaa   3840

aagctgggcg acttcctgcg gacgaatcag attacgacca tgtggctgac ctcgccgctc   3900

ttcaaccagc tttcgcaaga caatccggcg atgtttgaca gcttgcgcgc cttgatcgtc   3960

ggtggcgaag cgttgtcgcc gaagcacatc aaccgggtaa aaagtgccct tcctgacctg   4020

gaaatctgga acggatacgg cccgaccgaa aacacgacct tctcgacgtg ctatttgatt   4080

gagcagcatt ttgaagagca gattccgatc ggcaagccga ttgcaaactc caccgcgtat   4140

atcgtcgacg gcaacaatca gccgcagccg atcggcgtac cgggtgaact gtgcgtcggt   4200

ggtgacggtg tcgcaagagg ctatgtgaac aagccggaat taaccgccga aaagtttgtg   4260

cccaatccgt ttgcgcctgg cgaaacgatg tatcgcaccg gagatttggc gagatggctg   4320

ccggatggga cgattgagta tttgggccga atcgaccagc aggtcaaaat caggggatac   4380

cggatcgagc ttggggaaat cgagacggtc ttgtcccagc aggcacaagt aaaagaagca   4440

gtcgtggccg tgatcgagga ggcgaacggg caaaaagctc tctgcgctta ctttgtgcca   4500

gaacaggccg tcgacgccgc agagctgcga gaagcgatgt ccaaacaatt gcctggctac   4560

atggtccctg cttactatgt gcaaatggaa aagctgccgt tgaccgcgaa cggaaaggtc   4620

gaccgccggg cattgccgca gccatccggc gagcggacga caggaagcgc ctttgtcgct   4680

gcgcaaaatg ataccgaagc gaagctgcaa cagatttggc aagaagtttt gggcattccg   4740

gcaatcggca ttcacgacaa cttctttgaa atcggcggtc attccttgaa ggcgatgaac   4800

gtcatcacgc aagtccataa aacattccag gtggagctgc cgttaaaagc gctgtttgcc   4860

actccgacga tccatgagtt ggctgcgcat attgccacga gcggaaaaga gacgtatgtg   4920

ccgatcgagc ctgcaccgtt gcaagagtat tatcctgttt catctgcgca aaagcggatg   4980

tatgtcctgc gccagtttgc ggacacaggc acggtttata acatgccgag cgcgttgtat   5040

atcgaaggcg atctggatcg gaagcgtttt gaagccgcca tccacggatt ggtcgagcgg   5100

cacgaatcgc tgcgcacatc cttccacacc gtaaatggcg agcctgtcca gcgcgtacac   5160

gagcatgtcg agctgaatgt gcagtacgcg gaagtgacgg aagcgcaagt ggagccaacc   5220

gtcgagtcgt tcgtgcaagc atttgatctg acaaaagctc cgctattgcg ggtcggactt   5280

ttcaagctgg cagcgaaacg gcatctgttc ctgctggata tgcatcacat catctcggat   5340

ggcgtctcgg ccggaatcat tatggaagag ttctcgaagc tgtatcgagg cgaagaactg   5400

cctgcgcttt ccgtccatta caaagatttc gccgtctggc agtctgaact gttccagagc   5460

gacgtctata ccgagcatga aaactactgg ctgaacgcgt tttctggcga cattccggtg   5520

cttaacttgc cagccgattt ttctcgtccg ctgacacaga gctttgaagg agattgcgtt   5580

tcgttccagg cagacaaagc gttgctggac gatcttcaca agctcgctca ggagagccaa   5640

tcgacgttgt tcatggtatt gctggcggct tacaatgtgc tgcttgccaa gtacagcgga   5700

caggaagaca tcgtcgtcgg cacaccgatt gcgggcagat cgcacgccga tatcgagaac   5760

gttctgggga tgtttgtcaa cacgctcgct ttgcgcaact atccggtcga gacgaaacac   5820

ttccaggcat ttttggaaga ggtcaagcaa aatacgctgc aagcatacgc ccatcaagat   5880

tatccgttcg aagcactggt cgaaaagctg gacatccagc gggatctcag ccgcaatccg   5940

ctgtttgaca ccatgtttat tttgcaaaac ctggaccaaa aagcttacga gctggatggg   6000

ctgaaactgg aggcatatcc ggcacaagca ggcaacgcca aattcgatct cacgctggaa   6060

gcgcacgagg acgagacagg cattcatttt gcgctcgtct actcgaccaa attgttccag   6120

cgagaatcaa tcgaaagaat ggcgggtcac ttcctgcaag tgctgcgcca agtcgttgcc   6180

gaccaagcaa ctgccttgcg cgagatcagc ctgctcagcg aggaagagcg ccgaattgtg   6240

accgttgatt tcaacaacac gtttgcctat ccgcgcgatc tgacgattca ggagctgttc   6300

gagcagcagg cagcaaaaac tccggagcat gcagcggtcg tgatggacgg acagatgctg   6360

acgtatcggg agctgaacga aaaagcgaac cagctcgccc atgtccttcg tcaaaacgga   6420

gtcgggaaag agagcatcgt cggtctgctc gcagatcgtt cgctggaaat gattacaggc   6480

atcatgggga ttctcaaagc gggcggcgcc tacctgggac tggacccgga gcatccgtcc   6540

gaacgcctgg cttacatgtt ggaagatggc ggcgtgaaag ttgtcctcgt gcaaaagcac   6600

ttgctgccgc tcgtcggcga agggctgatg ccaatcgttt tggaagagga gagcctgcgc   6660

ccggaagatt gcggcaatcc ggcgattgtc aacggtgcga gtgacctggc ttatgtgatg   6720

tacacctcag gctctacagg caagccaaaa ggagtcatgg tcgagcatcg caacgtcacc   6780

cgcttggtca tgcatacgaa ttacgtgcaa gtgcgcgaga gcgaccggat gattcaaacc   6840

ggcgcgattg gcttcgacgc catgacattt gagatttttg gagccttgct gcacggggcc   6900

agcctgtatt tggtgagcaa ggacgtcttg ctggatgccg aaaagctggg cgacttcctg   6960

cggacgaatc agattacgac catgtggctg acctcgccgc tcttcaacca gctttcgcaa   7020

gacaatccgg cgatgtttga cagcttgcgc gccttgatcg tcggtggcga agcgttgtcg   7080

ccgaagcaca tcaaccgggt aaaaagtgcc cttcctgacc tggaaatctg gaacggatac   7140

ggcccgaccg aaaacacgac cttctcgacg tgctatttga ttgagcagca ttttgaagag   7200

cagattccga tcggcaagcc gattgcaaac tccaccgcgt atatcgtcga cggcaacaat   7260

cagccgcagc cgatcggcgt accgggtgaa ctgtgcgtcg gtggtgacgg tgtcgcaaga   7320

ggctatgtga acaagccgga attaaccgcc gaaaagtttg tgcccaatcc gtttgcgcct   7380

ggcgaaacga tgtatcgcac cggagatttg gcgagatggc tgccggatgg gacgattgag   7440

tatttgggcc gaatcgacca gcaggtcaaa atcaggggat accggatcga gcttggggaa   7500

atcgagacgg tcttgtccca gcaggcacaa gtaaaagaag cagtcgtggc cgtgatcgag   7560

gaggcgaacg ggcaaaaagc tctctgcgct tactttgtgc cagaacaggc cgtcgacgcc   7620

gcagagctgc gagaagcgat gtccaaacaa ttgcctggct acatggtccc tgcttactat   7680

gtgcaaatgg aaaagctgcc gttgaccgcg aacggaaagg tcgaccgccg ggcattgccg   7740

cagccatccg gcgagcggac gacaggaagc gcctttgtcg ctgcgcaaaa tgataccgaa   7800

gcgaagctgc aacagatttg gcaagaagtt ttgggcattc cggcaatcgg cattcacgac   7860

aacttctttg aaatcggcgg tcattccttg aaggcgatga acgtcatcac gcaagtccat   7920

aaaacattcc aggtggagct gccgttaaaa gcgctgtttg ccactccgac gatccatgag   7980

ttggctgcgc atatttcgga aaaaaccgag tacaccgcga ttcaacccgt ggcagcgcag   8040

gagttttacc cggtttcatc tgcgcaaaaa agaatgtata tcctgcaaca gttcgaaggc   8100

aacggaatca gctacaacat ttcgggtgcg attctcctgg aaggaaagct ggactacgcc   8160

cggtttgcca gcgctgtgca acagctggca gagcgccacg aagctttgcg cacctcgttc   8220

caccggatcg acggcgagcc tgtgcaaaaa gtgcacgagg aagtagaagt gccgcttttc   8280

atgctggagg ctcccgaaga ccaggcggag aaaatcatgc gcgagtttgt ccgtccgttt   8340

gatctcgggg tcgctccgct gatgcgaaca ggtttgctca agctgggcaa agaccgccat   8400

ttgtttttgc tcgacatgca ccatatcatc tcggacggcg tttcttcgca aattttgctg   8460

cgtgaatttg ccgagttgta ccagggagca gacttgcagc cgctttcgct gcaatacaaa   8520

gatttcgctg cttggcaaaa tgagctgttt cagacggagg catacaagaa gcaggagcag   8580

cactggctga acacgtttgc tgatgaaatt ccgctcttga acctgccgac tgactatccg   8640

cgccctagcg tgcaaagctt tgcaggcgat ctcgtccttt ttgccgccgg aaaagaactg   8700

ctggagcggt tgcaacaggt agcgtcagaa acaggcacca ccttgtacat gattttgctt   8760

gccgcctaca atgtgctgct gtccaagtat accggccagg aagacatcat cgtcgggacg   8820

cctgtcgctg gacgttccca tgcggacgtg gaaaacatca tgggcatatt cgtgaacaca   8880

ttggcgctgc gcaaccagcc tgccagcagc aaaacgatgt tagaaaataa tattacacaa   8940

tgtgactcaa tcaatgatgt ttatcttaaa gaagaagcaa taacattgat ggatatgctt   9000

gagagtcaac ttaagcacca ggcagatgga tatgttgtta ttgatcaaga agaatctctc   9060

agttacgctg atttctattt gagggtgaaa gagatagggt attgtctgtc agaaattagc   9120

tcaaagaatt cggtgggtat tgggcttttt tgtgatcctt ctatagattt aatttgtggt   9180

gcatggggta ttttgtcagc ggataaagct tatttgccgt tatcgcctga ctatccaact   9240

gaacgcctca aatatatgat agaagattct ggtattgatg tgatttttac gcaatcgcac   9300

ttaaaagcac agctacagga cattgcacca aaatcagtat taattatgac accagaagat   9360

gtcgctctga cgataaaaac acgaacaata gaagatattc tgggcacagt tcaagttcct   9420

aaacccacta gtctggctta tattatttat acctctggta gcacgggtaa gccaaaggga   9480

gtgatgattg aacatcacag tattgtaaat caaatgagat ttcttgcaaa agcgttcaaa   9540

ttaggatgtc attcccggat tttacagaaa acaccaatga gttttgatgc ggctcaatgg   9600

gaaattctag cgcctgcaat tggtggtcaa gtgattatgg gtcctttagg ttgctatcgc   9660

gatccggatg caattattaa aaccattctt cagcatcaag taacgacttt gcaatgtgtt   9720

cctactttgc tacaagcgtt actggataat cctaattttt tggattgctt atcattgact   9780

caagtattca gtgggggaga agcgctgaca accaaattag ccacgcaatt tttgaatagt   9840

tttactcact gtgaattaat caatttatat ggcccgacag aatgtacgat taattcatca   9900

tttttccggg tgacaaatga gactttgccg aattatcaaa cctctatttc gattggtgca   9960

cctgtagata ataccgaata ctacgttctt gatgatgata gattacctgt ggcggttggc  10020

gaaattggcg agctttatat ttcgggtgct caattagcac gtggttattt gcataaacca  10080

gaaatgacaa aagataaatt tatttgtaat caccttgtat caggaactca acatcaatgg  10140

ttatatcgaa cgggagatct ggtaaccaga ggggctgatg gtaatactta ttttgttggt  10200

cgggttgata gccaggtcaa attacgaggt taccgtattg agcttgatga aatacgccat  10260

gcgattgaag aacatagctg gataaagacg gcggcaatgt taattaagaa ggatgccaga  10320

acgggtttcc aaaatctcat cgcgtgtgtg gaattagatg agaaagaagc tgcattgatg  10380

gatcaaggta atagtagctc acatcacaaa tcaaaagccg ataaactaca ggtgaaagcc  10440

caactttcta attctggttg tcgaagtgaa gagttatgtg aaaatcgccc tacattctta  10500

cttccttatc aagaagggga gataaaacag agagaatatg catttggacg caagacatat  10560

cgctattttg agggaacaga aataacggta gagaaattaa aaaaattgct gacagccact  10620

caatcgaatg aaattagctc tttgccactg agtcatctaa ccctgaatga tttcggttat  10680

gcattgcgtt attttggtca gtttaccagc catcaacgtt tattgcccaa atatgcctat  10740

gcttcaccgg gtgctctcta tgcgacacaa atgtattttg aattgcataa tgttctcggt  10800

ttggatgcgg ggatttacta ttatcatcca gtgacacata agttaataaa aatttcaaca  10860

ttgagtcgtc ggcaaatgcc aacgataaaa gtgcatttta ttggcaagca tgaagccatt  10920

gagcccgttt ataagaacaa tatacaagaa gttctggaaa tggaagcggg ccatatgatg  10980

ggtctttttg atgacgtatt accggaaatt ggcttgagta ttggtaaaag tgaatatcaa  11040

gatgaatgtc cagattggta tgatggtgat attcaggatt attatcttgg tgcatttgaa  11100

atatgtagct atgaacatgg attgccgcca tttgagactg atatttattt acaaacacat  11160

gcccataaaa tacctgagat gccgtgtggt ttatatcact tttctaacgg ggaatttgta  11220

cgaataagtg atgatattgt ccgaaaaaag gatgttattg cgattaatca gcaagtttat  11280

gatcgctcca gttttggcgt gtcaattatt ccacgctgtg tccctgaatg gcattattat  11340

ataacactgg gtcgtcggtt acatgcgtta caaagtaatc cattgtatat tggattaatg  11400

tcatctggtt acagttcgaa gagcaataac gatttacctt cggcgaaaag gatgcgatct  11460

attctcaatg cacttgatag acctatggcg gcattttatt tctgcatagg tgggggtatt  11520

agccaagcgc aatatatgtg tgaaggcatg aaagaagatg ttgttcatat gaaagggcca  11580

gttgaaatca ttaaagatga tcttcaacaa caactccctc aatatatgat tccaaataag  11640

gtattagttt tcgataaatt acctttgacg gccaatggaa aagtggatta tcaatcttta  11700

tcagaatcta aagccgtgga gaatgtttca acacagcgtc tattggtgcc attacataca  11760

gatactgaaa taaggcttgg aaaaatttgg atggaagtac tgaaatggga ttcagtatct  11820

gccctcgatg attttttcga aagtgggggt aattctttga tggccgttgc aatggttaat  11880

aagatcaatg cggcctttaa tattcgtttt ccgttacaga tactttttca atctcctaat  11940

atagcagaat tggctaagtg gattgaacag acagactcta aaacaatatc aagattaatt  12000

ttattgaatc aggcaagcaa agaccccatt tactgttggc cgggtttggg cggatatcct  12060

atgagtttga gattgcttgc taataaagtc gttcctgatc gggcatttta tggaatacag  12120

gcatatggga taaacgagag tgaaataccg ttttcttcta tccagagaat ggcagaagag  12180

gatattaaag agataaagaa aatacagcca gaagggccat atatattgtg gggatattca  12240

tttggtgccc gagtagcatt tgaagttgca taccagcttg aacaagcggg agaagaagtt  12300

aacgcattga atttattggc tccgggatct cctcatcttg atatgaagca agcggaatat  12360

atggataaag gcgctgaatt tactaatccg gcttttgtta aaatactttt ttctgtattt  12420

tctcgttcaa tcaacagccc aatggttaaa acttgcttag aacaagtaaa tagtgaaacg  12480

acatttatta actttatatg tagtcgtttt aaaaacttgg aaccatcatt agtaaaacgt  12540

atcgttagga ttgtgacttt gacttatgat ttcaagtaca gtattgatga gctttatcac  12600

agacacctaa aggcacctat aactattttc aaggcgaata gagataatga ttcatttatc  12660

gaggaatcgg atgtgatttc atcaatgtcg cctaaaataa ttgaattaat atcggatcac  12720

tatcaactgt tggaaagtga aggtgttgct gagattgaga aaataatcta a           12771


<210>  15
<211>  6585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS being a putative synthetase of a fusion peptide consisting 
       of Phenylalanine and Indigoidine

<400>  15
atgttagcaa atcaggccaa tctcatcgac aacaagcggg aactggagca gcatgcgcta     60

gttccatatg cacagggcaa gtcgatccat caattgttcg aggaacaagc agaggctttt    120

ccagaccgcg ttgccatcgt ttttgaaaac aggcggcttt cgtatcagga gttgaacagg    180

aaagccaatc aactggcaag agccttgctc gaaaaagggg tgcaaacaga cagcatcgtc    240

ggtgtgatga tggagaagtc catcgaaaat gtcatcgcga ttctggccgt tcttaaagca    300

ggcggagcct atgtgcccat cgacatcgaa tatccccgcg atcgcatcca atatattttg    360

caggatagtc aaacgaaaat cgtgcttacc caaaaaagcg tcagccagct cgtgcatgac    420

gtcgggtaca gcggagaggt agttgtactc gacgaagaac agttggacgc tcgcgagact    480

gccaatctgc accagcccag caagcctacg gatcttgcct atgtcattta cacctcaggc    540

acgacaggca agccaaaagg caccatgctt gaacataaag gcatcgccaa tttgcaatcc    600

tttttccaaa attcgtttgg cgtcaccgag caagacagga tcgggctttt tgccagcatg    660

tcgttcgacg catccgtttg ggaaatgttc atggctttgc tgtctggcgc cagcctgtac    720

atcctttcca aacagacgat ccatgatttc gctgcatttg aacactattt gagtgaaaat    780

gaattgacca tcatcacact gccgccgact tatttgactc acctcacccc agagcgcatc    840

acctcgctac gcatcatgat tacggcagga tcagcttcct ccgcaccctt ggtaaacaaa    900

tggaaagaca aactcaggta cataaatgca tacggcccga cggaaacgag catttgcgcg    960

acgatctggg aagccccgtc caatcagctc tccgtgcaat cggttccgat cggcaaaccg   1020

attcaaaata cacatattta tatcgtcaat gaagacttgc agctactgcc gactggcagc   1080

gaaggcgaat tgtgcatcgg cggagtcggc ttggcaagag gctattggaa tcggcccgac   1140

ttgaccgcag aaaaattcgt agacaatccg ttcgtaccag gcgaaaaaat gtaccgcaca   1200

ggtgacttgg ccaaatggct gacggatgga acgatcgagt ttctcggcag aatcgaccat   1260

caggtgaaaa tcagaggtca tcgcatcgag cttggcgaaa tcgagtctgt tttgttggca   1320

catgaacaca tcacagaggc cgtggtcatt gccagagagg atcaacacgc gggacagtat   1380

ttgtgcgcct attatatttc gcaacaagaa gcaactcctg cgcagctcag agactacgcc   1440

gcccagaagc ttccggctta catgctgcca tcttatttcg tcaagctgga caaaatgccg   1500

cttacgccaa atgacaagat cgaccgcaaa gcgttgcccg agcctgatct tacggcaaac   1560

caaagccagg ctgcctacca tcctccgaga accgagacag aatcgattct cgtctccatc   1620

tggcaaaacg ttttgggaat tgaaaagatc gggattcgcg ataattttta ctcgctcggc   1680

ggagattcga tccaagcgat ccaggtcgtg gctcgtctgc attcctatca attgaagcta   1740

gagacgaaag acttgctgaa ttacccgacg atcgagcagg ttgctgagct ggcccgcttc   1800

ctttcgcggt cggaaaaaac cgagtacacc gcgattcaac ccgtggcagc gcaggagttt   1860

tacccggttt catctgcgca aaaaagaatg tatatcctgc aacagttcga aggcaacgga   1920

atcagctaca acatttcggg tgcgattctc ctggaaggaa agctggacta cgcccggttt   1980

gccagcgctg tgcaacagct ggcagagcgc cacgaagctt tgcgcacctc gttccaccgg   2040

atcgacggcg agcctgtgca aaaagtgcac gaggaagtag aagtgccgct tttcatgctg   2100

gaggctcccg aagaccaggc ggagaaaatc atgcgcgagt ttgtccgtcc gtttgatctc   2160

ggggtcgctc cgctgatgcg aacaggtttg ctcaagctgg gcaaagaccg ccatttgttt   2220

ttgctcgaca tgcaccatat catctcggac ggcgtttctt cgcaaatttt gctgcgtgaa   2280

tttgccgagt tgtaccaggg agcagacttg cagccgcttt cgctgcaata caaagatttc   2340

gctgcttggc aaaatgagct gtttcagacg gaggcataca agaagcagga gcagcactgg   2400

ctgaacacgt ttgctgatga aattccgctc ttgaacctgc cgactgacta tccgcgccct   2460

agcgtgcaaa gctttgcagg cgatctcgtc ctttttgccg ccggaaaaga actgctggag   2520

cggttgcaac aggtagcgtc agaaacaggc accaccttgt acatgatttt gcttgccgcc   2580

tacaatgtgc tgctgtccaa gtataccggc caggaagaca tcatcgtcgg gacgcctgtc   2640

gctggacgtt cccatgcgga cgtggaaaac atcatgggca tattcgtgaa cacattggcg   2700

ctgcgcaacc agcctgccag cagcaaaacg atgttagaaa ataatattac acaatgtgac   2760

tcaatcaatg atgtttatct taaagaagaa gcaataacat tgatggatat gcttgagagt   2820

caacttaagc accaggcaga tggatatgtt gttattgatc aagaagaatc tctcagttac   2880

gctgatttct atttgagggt gaaagagata gggtattgtc tgtcagaaat tagctcaaag   2940

aattcggtgg gtattgggct tttttgtgat ccttctatag atttaatttg tggtgcatgg   3000

ggtattttgt cagcggataa agcttatttg ccgttatcgc ctgactatcc aactgaacgc   3060

ctcaaatata tgatagaaga ttctggtatt gatgtgattt ttacgcaatc gcacttaaaa   3120

gcacagctac aggacattgc accaaaatca gtattaatta tgacaccaga agatgtcgct   3180

ctgacgataa aaacacgaac aatagaagat attctgggca cagttcaagt tcctaaaccc   3240

actagtctgg cttatattat ttatacctct ggtagcacgg gtaagccaaa gggagtgatg   3300

attgaacatc acagtattgt aaatcaaatg agatttcttg caaaagcgtt caaattagga   3360

tgtcattccc ggattttaca gaaaacacca atgagttttg atgcggctca atgggaaatt   3420

ctagcgcctg caattggtgg tcaagtgatt atgggtcctt taggttgcta tcgcgatccg   3480

gatgcaatta ttaaaaccat tcttcagcat caagtaacga ctttgcaatg tgttcctact   3540

ttgctacaag cgttactgga taatcctaat tttttggatt gcttatcatt gactcaagta   3600

ttcagtgggg gagaagcgct gacaaccaaa ttagccacgc aatttttgaa tagttttact   3660

cactgtgaat taatcaattt atatggcccg acagaatgta cgattaattc atcatttttc   3720

cgggtgacaa atgagacttt gccgaattat caaacctcta tttcgattgg tgcacctgta   3780

gataataccg aatactacgt tcttgatgat gatagattac ctgtggcggt tggcgaaatt   3840

ggcgagcttt atatttcggg tgctcaatta gcacgtggtt atttgcataa accagaaatg   3900

acaaaagata aatttatttg taatcacctt gtatcaggaa ctcaacatca atggttatat   3960

cgaacgggag atctggtaac cagaggggct gatggtaata cttattttgt tggtcgggtt   4020

gatagccagg tcaaattacg aggttaccgt attgagcttg atgaaatacg ccatgcgatt   4080

gaagaacata gctggataaa gacggcggca atgttaatta agaaggatgc cagaacgggt   4140

ttccaaaatc tcatcgcgtg tgtggaatta gatgagaaag aagctgcatt gatggatcaa   4200

ggtaatagta gctcacatca caaatcaaaa gccgataaac tacaggtgaa agcccaactt   4260

tctaattctg gttgtcgaag tgaagagtta tgtgaaaatc gccctacatt cttacttcct   4320

tatcaagaag gggagataaa acagagagaa tatgcatttg gacgcaagac atatcgctat   4380

tttgagggaa cagaaataac ggtagagaaa ttaaaaaaat tgctgacagc cactcaatcg   4440

aatgaaatta gctctttgcc actgagtcat ctaaccctga atgatttcgg ttatgcattg   4500

cgttattttg gtcagtttac cagccatcaa cgtttattgc ccaaatatgc ctatgcttca   4560

ccgggtgctc tctatgcgac acaaatgtat tttgaattgc ataatgttct cggtttggat   4620

gcggggattt actattatca tccagtgaca cataagttaa taaaaatttc aacattgagt   4680

cgtcggcaaa tgccaacgat aaaagtgcat tttattggca agcatgaagc cattgagccc   4740

gtttataaga acaatataca agaagttctg gaaatggaag cgggccatat gatgggtctt   4800

tttgatgacg tattaccgga aattggcttg agtattggta aaagtgaata tcaagatgaa   4860

tgtccagatt ggtatgatgg tgatattcag gattattatc ttggtgcatt tgaaatatgt   4920

agctatgaac atggattgcc gccatttgag actgatattt atttacaaac acatgcccat   4980

aaaatacctg agatgccgtg tggtttatat cacttttcta acggggaatt tgtacgaata   5040

agtgatgata ttgtccgaaa aaaggatgtt attgcgatta atcagcaagt ttatgatcgc   5100

tccagttttg gcgtgtcaat tattccacgc tgtgtccctg aatggcatta ttatataaca   5160

ctgggtcgtc ggttacatgc gttacaaagt aatccattgt atattggatt aatgtcatct   5220

ggttacagtt cgaagagcaa taacgattta ccttcggcga aaaggatgcg atctattctc   5280

aatgcacttg atagacctat ggcggcattt tatttctgca taggtggggg tattagccaa   5340

gcgcaatata tgtgtgaagg catgaaagaa gatgttgttc atatgaaagg gccagttgaa   5400

atcattaaag atgatcttca acaacaactc cctcaatata tgattccaaa taaggtatta   5460

gttttcgata aattaccttt gacggccaat ggaaaagtgg attatcaatc tttatcagaa   5520

tctaaagccg tggagaatgt ttcaacacag cgtctattgg tgccattaca tacagatact   5580

gaaataaggc ttggaaaaat ttggatggaa gtactgaaat gggattcagt atctgccctc   5640

gatgattttt tcgaaagtgg gggtaattct ttgatggccg ttgcaatggt taataagatc   5700

aatgcggcct ttaatattcg ttttccgtta cagatacttt ttcaatctcc taatatagca   5760

gaattggcta agtggattga acagacagac tctaaaacaa tatcaagatt aattttattg   5820

aatcaggcaa gcaaagaccc catttactgt tggccgggtt tgggcggata tcctatgagt   5880

ttgagattgc ttgctaataa agtcgttcct gatcgggcat tttatggaat acaggcatat   5940

gggataaacg agagtgaaat accgttttct tctatccaga gaatggcaga agaggatatt   6000

aaagagataa agaaaataca gccagaaggg ccatatatat tgtggggata ttcatttggt   6060

gcccgagtag catttgaagt tgcataccag cttgaacaag cgggagaaga agttaacgca   6120

ttgaatttat tggctccggg atctcctcat cttgatatga agcaagcgga atatatggat   6180

aaaggcgctg aatttactaa tccggctttt gttaaaatac ttttttctgt attttctcgt   6240

tcaatcaaca gcccaatggt taaaacttgc ttagaacaag taaatagtga aacgacattt   6300

attaacttta tatgtagtcg ttttaaaaac ttggaaccat cattagtaaa acgtatcgtt   6360

aggattgtga ctttgactta tgatttcaag tacagtattg atgagcttta tcacagacac   6420

ctaaaggcac ctataactat tttcaaggcg aatagagata atgattcatt tatcgaggaa   6480

tcggatgtga tttcatcaat gtcgcctaaa ataattgaat taatatcgga tcactatcaa   6540

ctgttggaaa gtgaaggtgt tgctgagatt gagaaaataa tctaa                   6585


<210>  16
<211>  14235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Indigoidine-tagged Tripeptide consisting of 
       Phenylalanine, Ornithine and Leucine

<400>  16
atgttagcaa atcaggccaa tctcatcgac aacaagcggg aactggagca gcatgcgcta     60

gttccatatg cacagggcaa gtcgatccat caattgttcg aggaacaagc agaggctttt    120

ccagaccgcg ttgccatcgt ttttgaaaac aggcggcttt cgtatcagga gttgaacagg    180

aaagccaatc aactggcaag agccttgctc gaaaaagggg tgcaaacaga cagcatcgtc    240

ggtgtgatga tggagaagtc catcgaaaat gtcatcgcga ttctggccgt tcttaaagca    300

ggcggagcct atgtgcccat cgacatcgaa tatccccgcg atcgcatcca atatattttg    360

caggatagtc aaacgaaaat cgtgcttacc caaaaaagcg tcagccagct cgtgcatgac    420

gtcgggtaca gcggagaggt agttgtactc gacgaagaac agttggacgc tcgcgagact    480

gccaatctgc accagcccag caagcctacg gatcttgcct atgtcattta cacctcaggc    540

acgacaggca agccaaaagg caccatgctt gaacataaag gcatcgccaa tttgcaatcc    600

tttttccaaa attcgtttgg cgtcaccgag caagacagga tcgggctttt tgccagcatg    660

tcgttcgacg catccgtttg ggaaatgttc atggctttgc tgtctggcgc cagcctgtac    720

atcctttcca aacagacgat ccatgatttc gctgcatttg aacactattt gagtgaaaat    780

gaattgacca tcatcacact gccgccgact tatttgactc acctcacccc agagcgcatc    840

acctcgctac gcatcatgat tacggcagga tcagcttcct ccgcaccctt ggtaaacaaa    900

tggaaagaca aactcaggta cataaatgca tacggcccga cggaaacgag catttgcgcg    960

acgatctggg aagccccgtc caatcagctc tccgtgcaat cggttccgat cggcaaaccg   1020

attcaaaata cacatattta tatcgtcaat gaagacttgc agctactgcc gactggcagc   1080

gaaggcgaat tgtgcatcgg cggagtcggc ttggcaagag gctattggaa tcggcccgac   1140

ttgaccgcag aaaaattcgt agacaatccg ttcgtaccag gcgaaaaaat gtaccgcaca   1200

ggtgacttgg ccaaatggct gacggatgga acgatcgagt ttctcggcag aatcgaccat   1260

caggtgaaaa tcagaggtca tcgcatcgag cttggcgaaa tcgagtctgt tttgttggca   1320

catgaacaca tcacagaggc cgtggtcatt gccagagagg atcaacacgc gggacagtat   1380

ttgtgcgcct attatatttc gcaacaagaa gcaactcctg cgcagctcag agactacgcc   1440

gcccagaagc ttccggctta catgctgcca tcttatttcg tcaagctgga caaaatgccg   1500

cttacgccaa atgacaagat cgaccgcaaa gcgttgcccg agcctgatct tacggcaaac   1560

caaagccagg ctgcctacca tcctccgaga accgagacag aatcgattct cgtctccatc   1620

tggcaaaacg ttttgggaat tgaaaagatc gggattcgcg ataattttta ctcgctcggc   1680

ggagattcga tccaagcgat ccaggtcgtg gctcgtctgc attcctatca attgaagcta   1740

gagacgaaag acttgctgaa ttacccgacg atcgagcagg ttgctctttt tgtcaagagc   1800

acgacgagaa aaagcgatca gggcatcatc gctggaaacg taccgcttac acccattcag   1860

aagtggtttt tcgggaaaaa ctttacgaat acaggccatt ggaaccaatc gtctgtgctc   1920

tatcgcccgg aaggctttga tcctaaagtc atccaaagtg tcatggacaa aatcatcgaa   1980

caccacgacg cgctccgcat ggtctatcag cacgaaaacg gaaatgtcgt tcagcacaac   2040

cgcggcttgg gtggacaatt atacgatttc ttctcttata atctgaccgc gcaaccagac   2100

gtccagcagg cgatcgaagc agagacgcaa cgtctgcaca gcagcatgaa tttgcaggaa   2160

ggacctctgg tgaaggttgc cttatttcag acgttacatg gcgatcattt gtttctcgca   2220

attcatcatt tggtcgtgga tggcatttcc tggcgcattt tgtttgaaga tttggcaacc   2280

ggatacgcgc aggcacttgc agggcaagcg atcagtctgc ccgaaaaaac ggattctttt   2340

caaagctggt cacaatggtt gcaagaatat gcgaacgagg cggatttgct gagcgagatt   2400

ccgtactggg agagtctcga atcgcaagca aaaaatgtgt ccctgccgaa agactatgaa   2460

gtgaccgact gcaaacaaaa gagcgtgcga aacatgcgga tacggctgca cccggaagag   2520

accgagcagt tgttgaagca cgccaatcag gcctatcaaa cggaaatcaa cgatctgttg   2580

ttggcggcgc tcggcttggc ttttgcggag tggagcaagc ttgcgcaaat cgtcattcat   2640

ttggaggggc acgggcgcga ggacatcatc gaacaggcaa acgtggccag aacggtcgga   2700

tggtttacgt cgcaatatcc ggtattgctc gacttgaagc aaaccgctcc cttgtccgac   2760

tatatcaagc tcaccaaaga gaatatgcgg aagattcctc gtaaagggat cggttacgac   2820

atcttgaagc atgtgacact tccagaaaat cgcggttcct tatccttccg cgtgcagccg   2880

gaagtgacgt tcaactactt gggacagttt gatgcggaca tgagaacgga actgtttacc   2940

cgctcaccct acagcggcgg caacacgtta ggcgcagatg gcaaaaacaa tctgagtcct   3000

gagtcagagg tgtacaccgc tttgaatata accggattga ttgaaggcgg agagctcgtc   3060

ctcacattct cttacagctc ggagcagtat cgggaagagt ccatccagca attgagccaa   3120

agttatcaaa agcatctgct tgccatcatc gcgcattgca ccgagaaaaa agaagtagag   3180

cgaacggcgc atattgccga gagcgcattc gagcagttcg agacgatcca gccagtcgag   3240

cctgccgcgt tttatcccgt gtcgtttgcc caaaagcgaa tgtacatcct gcatcagttc   3300

gaaggaagcg ggatcagcta caacgtgccg agtgtgctgg tgctggaagg caagctcgat   3360

tatgaccgct ttgctgctgc catccagagc ctggttaaac ggcatgaatc tttgcgcacc   3420

tcgttccatt cggtaaacgg ggaaccgctg caacgagtac atccggatgt cgagctgcct   3480

gtccgccttt tggaggcgac agaagatcag agcgaatcgc tcatccagga gctaatccag   3540

ccgtttgatc tggagatagc cccgttgttc agagtgaatc tgatcaagct tggcgcagag   3600

cggcacttgt tcttcatgga tatgcaccac attatttccg atggcgtatc gcttgcggtc   3660

atcgtcgagg aaattgccag cttgtatgca ggaaaacagc tttccgacct gcgcatccag   3720

tacaaagact ttgctgtgtg gcagaccaag ctggctcagt cggatcgctt ccaaaaacag   3780

gaggattttt ggacccggac gtttgccggg gagattcctt tgctgaatct gccccatgat   3840

tatccaagac cttctgtgca gagctttgac ggtgacacgg tcgcgcttgg caccggacat   3900

cacctgctgg aacaactgcg caagctcgct gccgagactg gcacgacctt gttcatggtg   3960

ctgctggctg cctaccatgt gttgctctcc aagtacgccg gacaggaaga aatcgtcgtc   4020

ggcacaccga tcgcaggccg ctcgcacgca gatgtcgagc gcattgtcgg gatgttcgtc   4080

aacacgctcg ctttgaaaaa tacggccgct ggcagcctga gcttccgcgc ctttttggaa   4140

gacgtgaagc aaaatgcgct ccatgccttc gagcatcaag actatccgtt cgagcatctg   4200

gtcgagaagc tgcaagtgcg gcgcgatctg agcagaaacc cgctgtttga tacgatgttc   4260

agcctggggc ttgccgaatc agccgaagga gaagtagcgg atctgaaagt gtcgccttat   4320

ccggtgaacg gccacatcgc caaattcgac ctttccctgg atgcgatgga aaaacaggat   4380

ggacttcttg ttcaattcag ctattgcacg aagctgttcg caaaagaaac ggttgatcga   4440

ctggccgccc attacgttca gcttttgcaa acaatcacag ccgatcccga catcgagctc   4500

gcccggatca gcgtgttgtc caaagcagag acggagcaca tgctgcacag cttcctcgca   4560

accaaaacag cctatccgac ggacaaaacg ttccagaagc tgttcgagga gcaagtggaa   4620

aaaacaccga acgagattgc cgttctgttc ggcaatgaac agctgaccta tcaggagttg   4680

aatgcaaaag caaaccagct cgcccgcgtc ctgcggcgaa aaggcgtcaa gccggagagc   4740

accgtcggca tcctcgtaga ccgctcgctc tacatggtca tcggcatgct ggccgtgttg   4800

aaagcaggcg gaacattcgt cccgattgat ccggactacc cgctggagcg ccaagcgttc   4860

atgctcgaag acagcgaggc gaagctgctg ctcaccttgc aaaaaatgaa cagtcaagtt   4920

gccttccctt atgaaacctt ttatctggat acagagacag tggatcagga ggagacgggc   4980

aatctggagc acgttgcgca gccggagaac gtcgcttaca tcatctacac atccggtacg   5040

acgggcaagc caaaaggggt cgtcatcgag caccgcagct atgccaatgt cgcatttgcc   5100

tggaaagacg aatatcacct ggacagcttc ccggtccgtt tgctgcaaat ggcgagcttc   5160

gcctttgacg tctcgacggg cgattttgcc agggcgctgc tgacaggcgg gcaactggtc   5220

atctgcccga atggggtcaa aatggaccca gcttcgctgt acgagaccat caggcgtcac   5280

gaaattacca ttttcgaagc gacacccgcc ttgatcatgc cgttgatgca ctacgtttac   5340

gaaaacgaac tggatatgag ccaaatgaag ctgctgattc tcggagcaga cagctgcccg   5400

gcggaagact tcaaaacgtt gctcgcgcgc ttcggtcaga agatgcgcat tatcaacagc   5460

tacggcgtga cagaggcgtg cattgacacc agctactacg aagaaacaga cgtcaccgcc   5520

atccgctcgg gaacggtgcc gatcggcaaa ccgcttccga acatgacgat gtacgtggtc   5580

gatgcgcatt tgaatttgca gcctgtcggc gtcgtaggcg aattgtgcat cggcggagca   5640

ggggttgcgc gcggttattt gaacagacct gagctgacgg aagagaagtt cgtgccgaat   5700

ccgttcgccc caggtgaacg attgtaccgc acaggtgatc tggcgaagtg gcgcgcagat   5760

ggcaatgtcg agttcctcgg acgcaatgac caccaggtaa aaatcagggg tgtccgcatc   5820

gagctgggcg agatcgagac acaactgcgc aagctggacg gaattacgga agcagtcgtg   5880

gttgcgagag aagatcgcgg gcaggaaaag gaattgtgcg catacgtcgt ggcggaccac   5940

aagcttgaca ccgcagaatt gcgggcgaat ttgctgaagg aactgccgca agcgatgatt   6000

ccagcgtatt tcgtcacctt ggatgcgctg ccgctgactg ccaatggcaa agtagacaga   6060

cgttccttgc cagcgccgga tgtcaccatg ctgagaacga ccgagtatgt agcgccgcgc   6120

tccgtctggg aagcccgatt ggcccaagta tgggagcagg tgctgaatgt tccgcaagtg   6180

ggtgcgctag acgacttttt cgcgctcggc ggtcactcat tgcgtgccat gcgcgtcctt   6240

tccagcatgc acaacgaata ccaggtcgac atcccgctgc gcatcttgtt cgaaaaaccg   6300

acgattcagg aactggcggc gttcatcgaa gagacagcca aagggaatgt cttctcgatc   6360

gagcctgtgc aaaagcaagc gtactatccg gtctcctcgg cacaaaagcg catgtacatc   6420

ctcgatcaat ttgagggagt cggcatcagc tacaacatgc cgtcgactat gctgatcgaa   6480

ggcaagctgg agcgaacacg ggtagaagcg gcgttccagc gcttgattgc gcgacatgaa   6540

agcctgcgca cttcgtttgc cgtcgtcaac ggagagcctg tgcaaaacat tcacgaggac   6600

gttccgtttg cgcttgccta ttcggaagtc acagaacagg aggcgcgcga actcgtttct   6660

tctctcgtgc agccgttcga tctggaggtc gcaccactca tccgcgtgtc gctgctgaaa   6720

atcggcgagg atcgttacgt gctctttacc gacatgcatc acagcatttc cgatggcgta   6780

tcctccggca ttcttttggc agagtgggtg cagctgtacc agggtgacgt tttgccggag   6840

ctgcgtatcc agtacaagga ctttgctgtg tggcaacaag agttttccca gtcggctgcc   6900

ttccacaagc aggaagcgta ctggttgcaa acgtttgccg atgacattcc tgtgctgaac   6960

ttgccgaccg atttcacccg ccccagcacc caaagctttg ccggggatca gtgcacgatc   7020

ggcgcgggca aagcgctcac ggaaggcttg caccagttgg cgcaggcgac gggaacgact   7080

ttgtacatgg ttttgctcgc cgcgtacaac gtgctgctcg ccaagtatgc cgggcaggag   7140

gacatcatcg tcggcacgcc gattacaggc agatcccatg ccgatctcga accgatcgtc   7200

ggcatgttcg tgaacacctt ggcgatgcga aacaaaccgc agcgcgaaaa gacttttagc   7260

gagtttttgc aagaagtcaa gcaaaatgcg ctggatgcgt acggccatca ggattacccg   7320

tttgaagaac tggtggaaaa gctcgcgatc gcgcgcgatt tgagccgaaa tccgctgttt   7380

gacaccgtgt ttacgttcca aaacagcacg gaagaggtca tgacgctgcc tgaatgcacg   7440

cttgcgccgt ttatgacgga cgaaacaggc cagcacgcca agttcgactt gactttcagc   7500

gctacggaag agcgggaaga aatgacgatt ggcgtggagt acagcacaag cttgtttacg   7560

cgggaaacga tggaacggtt cagccgccac ttcctgacga ttgcagcgag catcgtgcaa   7620

aatccgcaca tccgtctggg cgagatcgac atgcttttgc cagaagaaaa acagcagatt   7680

ttggccgggt tcaacgatac ggcagtcagc tatgcgctgg acaaaacgct gcaccagcta   7740

ttcgaagagc aggtcgacaa aacaccggat caggcagcgc ttctctttag cgagcaatcg   7800

ctgacgtaca gcgaactgaa cgagcgagca aacagactgg caagggtcct gcgcgcaaaa   7860

ggagtcggac cggaccgtct ggtagcgatc atggcggagc gctcgccgga aatggtgatc   7920

ggtattctcg gtattttgaa ggcaggcggc gcttatgttc ccgtcgatcc cggctatccg   7980

caggagcgca ttcagtacct gctcgaagat agcaacgcag ccctgctgct cagccaggcg   8040

catctgttgc cgctgttggc ccaggtgtca agcgagctgc cggagtgcct tgatctgaac   8100

gctgaactgg atgccggact gagcggctcc aacctgccag ctgtcaacca accgactgac   8160

cttgcctacg tcatctatac atccggtacg accggcaagc cgaagggtgt catgatcccg   8220

catcaaggaa tcgtgaactg cttgcagtgg agaagagacg aatacgggtt cgggccgagt   8280

gacaaggcgt tgcaagtgtt ctcctttgcc ttcgacggtt ttgtagccag cttgttcgct   8340

ccgctgctcg gaggggcaac gtgcgtgttg ccgcaagaag cagctgccaa agacccggtc   8400

gcgctgaaaa aactgatggc cgcaacggaa gtcacccatt actacggcgt accgagtctg   8460

ttccaggcca ttctcgattg ctcgacgaca accgacttca atcagttgcg ttgcgtcact   8520

ttgggcggcg agaagctgcc tgtgcagctt gtgcaaaaaa caaaagaaaa gcatccggca   8580

atcgagatca acaacgagta cggcccgacg gaaaacagcg tcgtcaccac catctcgcgc   8640

tcgattgaag cggggcaagc gatcacgatt ggccgaccgc ttgcgaacgt ccaagtctac   8700

attgtagatg agcagcatca cttgcagccg attggcgtgg tcggtgagct gtgcatcggc   8760

ggagccgggc ttgccagagg ctatctgaac aaaccggagc tgaccgcaga gaagtttgtc   8820

gcaaatccgt tccgaccagg cgagcgcatg tacaaaacag gcgacttggt aaaatggcgg   8880

acggatggca cgatcgagta catcggccgc gcagacgaac aggtcaaggt gagagggtat   8940

cgcatcgaga tcggcgagat cgagagcgcc gtactcgctt accagggcat cgatcaagcg   9000

gtggtcgttg cgcgagacga tgacgctacg gctggttcct atctttgcgc ctactttgtc   9060

gcagcaacag ccgtgtccgt atccggcttg agaagccatc tggccaaaga gctgcctgct   9120

tacatgattc cgagctattt cgtcgagctg gatcagctgc cgctttccgc caatggaaaa   9180

gtggatcgca aagctttgcc gaagccgcaa cagtccgatg cgaccacgcg cgaatacgtg   9240

gccccgagga atgcgaccga acagcaactg gcagccatct ggcaagaagt tttgggagta   9300

gagccaatcg gcatcaccga ccagttcttt gaactcggag gacattcctt aaaagctacg   9360

ctgttgattg ccaaagtgta tgagtacatg caaatcgagc tgccgctgaa tctcatcttc   9420

cagtatccga cgatcgaaaa ggtggccgat ttcatcacgt cggaaaaaac cgagtacacc   9480

gcgattcaac ccgtggcagc gcaggagttt tacccggttt catctgcgca aaaaagaatg   9540

tatatcctgc aacagttcga aggcaacgga atcagctaca acatttcggg tgcgattctc   9600

ctggaaggaa agctggacta cgcccggttt gccagcgctg tgcaacagct ggcagagcgc   9660

cacgaagctt tgcgcacctc gttccaccgg atcgacggcg agcctgtgca aaaagtgcac   9720

gaggaagtag aagtgccgct tttcatgctg gaggctcccg aagaccaggc ggagaaaatc   9780

atgcgcgagt ttgtccgtcc gtttgatctc ggggtcgctc cgctgatgcg aacaggtttg   9840

ctcaagctgg gcaaagaccg ccatttgttt ttgctcgaca tgcaccatat catctcggac   9900

ggcgtttctt cgcaaatttt gctgcgtgaa tttgccgagt tgtaccaggg agcagacttg   9960

cagccgcttt cgctgcaata caaagatttc gctgcttggc aaaatgagct gtttcagacg  10020

gaggcataca agaagcagga gcagcactgg ctgaacacgt ttgctgatga aattccgctc  10080

ttgaacctgc cgactgacta tccgcgccct agcgtgcaaa gctttgcagg cgatctcgtc  10140

ctttttgccg ccggaaaaga actgctggag cggttgcaac aggtagcgtc agaaacaggc  10200

accaccttgt acatgatttt gcttgccgcc tacaatgtgc tgctgtccaa gtataccggc  10260

caggaagaca tcatcgtcgg gacgcctgtc gctggacgtt cccatgcgga cgtggaaaac  10320

atcatgggca tattcgtgaa cacattggcg ctgcgcaacc agcctgccag cagcaaaacg  10380

atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa  10440

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt  10500

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata  10560

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat  10620

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg  10680

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt  10740

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca  10800

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat  10860

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct  10920

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg  10980

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca  11040

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt  11100

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat  11160

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat  11220

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa  11280

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg  11340

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat  11400

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat  11460

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta  11520

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt  11580

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct  11640

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt  11700

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca  11760

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta  11820

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa  11880

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta  11940

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa  12000

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa  12060

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat  12120

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa  12180

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat  12240

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca  12300

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat  12360

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg  12420

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg  12480

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag  12540

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag  12600

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat  12660

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt  12720

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc  12780

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt  12840

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta  12900

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt  12960

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa  13020

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc  13080

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat  13140

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag  13200

cgtctattgg tgccattaca tacagatact gaaataaggc ttggaaaaat ttggatggaa  13260

gtactgaaat gggattcagt atctgccctc gatgattttt tcgaaagtgg gggtaattct  13320

ttgatggccg ttgcaatggt taataagatc aatgcggcct ttaatattcg ttttccgtta  13380

cagatacttt ttcaatctcc taatatagca gaattggcta agtggattga acagacagac  13440

tctaaaacaa tatcaagatt aattttattg aatcaggcaa gcaaagaccc catttactgt  13500

tggccgggtt tgggcggata tcctatgagt ttgagattgc ttgctaataa agtcgttcct  13560

gatcgggcat tttatggaat acaggcatat gggataaacg agagtgaaat accgttttct  13620

tctatccaga gaatggcaga agaggatatt aaagagataa agaaaataca gccagaaggg  13680

ccatatatat tgtggggata ttcatttggt gcccgagtag catttgaagt tgcataccag  13740

cttgaacaag cgggagaaga agttaacgca ttgaatttat tggctccggg atctcctcat  13800

cttgatatga agcaagcgga atatatggat aaaggcgctg aatttactaa tccggctttt  13860

gttaaaatac ttttttctgt attttctcgt tcaatcaaca gcccaatggt taaaacttgc  13920

ttagaacaag taaatagtga aacgacattt attaacttta tatgtagtcg ttttaaaaac  13980

ttggaaccat cattagtaaa acgtatcgtt aggattgtga ctttgactta tgatttcaag  14040

tacagtattg atgagcttta tcacagacac ctaaaggcac ctataactat tttcaaggcg  14100

aatagagata atgattcatt tatcgaggaa tcggatgtga tttcatcaat gtcgcctaaa  14160

ataattgaat taatatcgga tcactatcaa ctgttggaaa gtgaaggtgt tgctgagatt  14220

gagaaaataa tctaa                                                   14235


<210>  17
<211>  17334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Valine-Indigoidine-tagged Tripeptide 
       consisting of Phenylalanine, Ornithine and Leucine. Valine is 
       here used as spacer.

<400>  17
atgttagcaa atcaggccaa tctcatcgac aacaagcggg aactggagca gcatgcgcta     60

gttccatatg cacagggcaa gtcgatccat caattgttcg aggaacaagc agaggctttt    120

ccagaccgcg ttgccatcgt ttttgaaaac aggcggcttt cgtatcagga gttgaacagg    180

aaagccaatc aactggcaag agccttgctc gaaaaagggg tgcaaacaga cagcatcgtc    240

ggtgtgatga tggagaagtc catcgaaaat gtcatcgcga ttctggccgt tcttaaagca    300

ggcggagcct atgtgcccat cgacatcgaa tatccccgcg atcgcatcca atatattttg    360

caggatagtc aaacgaaaat cgtgcttacc caaaaaagcg tcagccagct cgtgcatgac    420

gtcgggtaca gcggagaggt agttgtactc gacgaagaac agttggacgc tcgcgagact    480

gccaatctgc accagcccag caagcctacg gatcttgcct atgtcattta cacctcaggc    540

acgacaggca agccaaaagg caccatgctt gaacataaag gcatcgccaa tttgcaatcc    600

tttttccaaa attcgtttgg cgtcaccgag caagacagga tcgggctttt tgccagcatg    660

tcgttcgacg catccgtttg ggaaatgttc atggctttgc tgtctggcgc cagcctgtac    720

atcctttcca aacagacgat ccatgatttc gctgcatttg aacactattt gagtgaaaat    780

gaattgacca tcatcacact gccgccgact tatttgactc acctcacccc agagcgcatc    840

acctcgctac gcatcatgat tacggcagga tcagcttcct ccgcaccctt ggtaaacaaa    900

tggaaagaca aactcaggta cataaatgca tacggcccga cggaaacgag catttgcgcg    960

acgatctggg aagccccgtc caatcagctc tccgtgcaat cggttccgat cggcaaaccg   1020

attcaaaata cacatattta tatcgtcaat gaagacttgc agctactgcc gactggcagc   1080

gaaggcgaat tgtgcatcgg cggagtcggc ttggcaagag gctattggaa tcggcccgac   1140

ttgaccgcag aaaaattcgt agacaatccg ttcgtaccag gcgaaaaaat gtaccgcaca   1200

ggtgacttgg ccaaatggct gacggatgga acgatcgagt ttctcggcag aatcgaccat   1260

caggtgaaaa tcagaggtca tcgcatcgag cttggcgaaa tcgagtctgt tttgttggca   1320

catgaacaca tcacagaggc cgtggtcatt gccagagagg atcaacacgc gggacagtat   1380

ttgtgcgcct attatatttc gcaacaagaa gcaactcctg cgcagctcag agactacgcc   1440

gcccagaagc ttccggctta catgctgcca tcttatttcg tcaagctgga caaaatgccg   1500

cttacgccaa atgacaagat cgaccgcaaa gcgttgcccg agcctgatct tacggcaaac   1560

caaagccagg ctgcctacca tcctccgaga accgagacag aatcgattct cgtctccatc   1620

tggcaaaacg ttttgggaat tgaaaagatc gggattcgcg ataattttta ctcgctcggc   1680

ggagattcga tccaagcgat ccaggtcgtg gctcgtctgc attcctatca attgaagcta   1740

gagacgaaag acttgctgaa ttacccgacg atcgagcagg ttgctctttt tgtcaagagc   1800

acgacgagaa aaagcgatca gggcatcatc gctggaaacg taccgcttac acccattcag   1860

aagtggtttt tcgggaaaaa ctttacgaat acaggccatt ggaaccaatc gtctgtgctc   1920

tatcgcccgg aaggctttga tcctaaagtc atccaaagtg tcatggacaa aatcatcgaa   1980

caccacgacg cgctccgcat ggtctatcag cacgaaaacg gaaatgtcgt tcagcacaac   2040

cgcggcttgg gtggacaatt atacgatttc ttctcttata atctgaccgc gcaaccagac   2100

gtccagcagg cgatcgaagc agagacgcaa cgtctgcaca gcagcatgaa tttgcaggaa   2160

ggacctctgg tgaaggttgc cttatttcag acgttacatg gcgatcattt gtttctcgca   2220

attcatcatt tggtcgtgga tggcatttcc tggcgcattt tgtttgaaga tttggcaacc   2280

ggatacgcgc aggcacttgc agggcaagcg atcagtctgc ccgaaaaaac ggattctttt   2340

caaagctggt cacaatggtt gcaagaatat gcgaacgagg cggatttgct gagcgagatt   2400

ccgtactggg agagtctcga atcgcaagca aaaaatgtgt ccctgccgaa agactatgaa   2460

gtgaccgact gcaaacaaaa gagcgtgcga aacatgcgga tacggctgca cccggaagag   2520

accgagcagt tgttgaagca cgccaatcag gcctatcaaa cggaaatcaa cgatctgttg   2580

ttggcggcgc tcggcttggc ttttgcggag tggagcaagc ttgcgcaaat cgtcattcat   2640

ttggaggggc acgggcgcga ggacatcatc gaacaggcaa acgtggccag aacggtcgga   2700

tggtttacgt cgcaatatcc ggtattgctc gacttgaagc aaaccgctcc cttgtccgac   2760

tatatcaagc tcaccaaaga gaatatgcgg aagattcctc gtaaagggat cggttacgac   2820

atcttgaagc atgtgacact tccagaaaat cgcggttcct tatccttccg cgtgcagccg   2880

gaagtgacgt tcaactactt gggacagttt gatgcggaca tgagaacgga actgtttacc   2940

cgctcaccct acagcggcgg caacacgtta ggcgcagatg gcaaaaacaa tctgagtcct   3000

gagtcagagg tgtacaccgc tttgaatata accggattga ttgaaggcgg agagctcgtc   3060

ctcacattct cttacagctc ggagcagtat cgggaagagt ccatccagca attgagccaa   3120

agttatcaaa agcatctgct tgccatcatc gcgcattgca ccgagaaaaa agaagtagag   3180

cgaacggcgc atattgccga gagcgcattc gagcagttcg agacgatcca gccagtcgag   3240

cctgccgcgt tttatcccgt gtcgtttgcc caaaagcgaa tgtacatcct gcatcagttc   3300

gaaggaagcg ggatcagcta caacgtgccg agtgtgctgg tgctggaagg caagctcgat   3360

tatgaccgct ttgctgctgc catccagagc ctggttaaac ggcatgaatc tttgcgcacc   3420

tcgttccatt cggtaaacgg ggaaccgctg caacgagtac atccggatgt cgagctgcct   3480

gtccgccttt tggaggcgac agaagatcag agcgaatcgc tcatccagga gctaatccag   3540

ccgtttgatc tggagatagc cccgttgttc agagtgaatc tgatcaagct tggcgcagag   3600

cggcacttgt tcttcatgga tatgcaccac attatttccg atggcgtatc gcttgcggtc   3660

atcgtcgagg aaattgccag cttgtatgca ggaaaacagc tttccgacct gcgcatccag   3720

tacaaagact ttgctgtgtg gcagaccaag ctggctcagt cggatcgctt ccaaaaacag   3780

gaggattttt ggacccggac gtttgccggg gagattcctt tgctgaatct gccccatgat   3840

tatccaagac cttctgtgca gagctttgac ggtgacacgg tcgcgcttgg caccggacat   3900

cacctgctgg aacaactgcg caagctcgct gccgagactg gcacgacctt gttcatggtg   3960

ctgctggctg cctaccatgt gttgctctcc aagtacgccg gacaggaaga aatcgtcgtc   4020

ggcacaccga tcgcaggccg ctcgcacgca gatgtcgagc gcattgtcgg gatgttcgtc   4080

aacacgctcg ctttgaaaaa tacggccgct ggcagcctga gcttccgcgc ctttttggaa   4140

gacgtgaagc aaaatgcgct ccatgccttc gagcatcaag actatccgtt cgagcatctg   4200

gtcgagaagc tgcaagtgcg gcgcgatctg agcagaaacc cgctgtttga tacgatgttc   4260

agcctggggc ttgccgaatc agccgaagga gaagtagcgg atctgaaagt gtcgccttat   4320

ccggtgaacg gccacatcgc caaattcgac ctttccctgg atgcgatgga aaaacaggat   4380

ggacttcttg ttcaattcag ctattgcacg aagctgttcg caaaagaaac ggttgatcga   4440

ctggccgccc attacgttca gcttttgcaa acaatcacag ccgatcccga catcgagctc   4500

gcccggatca gcgtgttgtc caaagcagag acggagcaca tgctgcacag cttcctcgca   4560

accaaaacag cctatccgac ggacaaaacg ttccagaagc tgttcgagga gcaagtggaa   4620

aaaacaccga acgagattgc cgttctgttc ggcaatgaac agctgaccta tcaggagttg   4680

aatgcaaaag caaaccagct cgcccgcgtc ctgcggcgaa aaggcgtcaa gccggagagc   4740

accgtcggca tcctcgtaga ccgctcgctc tacatggtca tcggcatgct ggccgtgttg   4800

aaagcaggcg gaacattcgt cccgattgat ccggactacc cgctggagcg ccaagcgttc   4860

atgctcgaag acagcgaggc gaagctgctg ctcaccttgc aaaaaatgaa cagtcaagtt   4920

gccttccctt atgaaacctt ttatctggat acagagacag tggatcagga ggagacgggc   4980

aatctggagc acgttgcgca gccggagaac gtcgcttaca tcatctacac atccggtacg   5040

acgggcaagc caaaaggggt cgtcatcgag caccgcagct atgccaatgt cgcatttgcc   5100

tggaaagacg aatatcacct ggacagcttc ccggtccgtt tgctgcaaat ggcgagcttc   5160

gcctttgacg tctcgacggg cgattttgcc agggcgctgc tgacaggcgg gcaactggtc   5220

atctgcccga atggggtcaa aatggaccca gcttcgctgt acgagaccat caggcgtcac   5280

gaaattacca ttttcgaagc gacacccgcc ttgatcatgc cgttgatgca ctacgtttac   5340

gaaaacgaac tggatatgag ccaaatgaag ctgctgattc tcggagcaga cagctgcccg   5400

gcggaagact tcaaaacgtt gctcgcgcgc ttcggtcaga agatgcgcat tatcaacagc   5460

tacggcgtga cagaggcgtg cattgacacc agctactacg aagaaacaga cgtcaccgcc   5520

atccgctcgg gaacggtgcc gatcggcaaa ccgcttccga acatgacgat gtacgtggtc   5580

gatgcgcatt tgaatttgca gcctgtcggc gtcgtaggcg aattgtgcat cggcggagca   5640

ggggttgcgc gcggttattt gaacagacct gagctgacgg aagagaagtt cgtgccgaat   5700

ccgttcgccc caggtgaacg attgtaccgc acaggtgatc tggcgaagtg gcgcgcagat   5760

ggcaatgtcg agttcctcgg acgcaatgac caccaggtaa aaatcagggg tgtccgcatc   5820

gagctgggcg agatcgagac acaactgcgc aagctggacg gaattacgga agcagtcgtg   5880

gttgcgagag aagatcgcgg gcaggaaaag gaattgtgcg catacgtcgt ggcggaccac   5940

aagcttgaca ccgcagaatt gcgggcgaat ttgctgaagg aactgccgca agcgatgatt   6000

ccagcgtatt tcgtcacctt ggatgcgctg ccgctgactg ccaatggcaa agtagacaga   6060

cgttccttgc cagcgccgga tgtcaccatg ctgagaacga ccgagtatgt agcgccgcgc   6120

tccgtctggg aagcccgatt ggcccaagta tgggagcagg tgctgaatgt tccgcaagtg   6180

ggtgcgctag acgacttttt cgcgctcggc ggtcactcat tgcgtgccat gcgcgtcctt   6240

tccagcatgc acaacgaata ccaggtcgac atcccgctgc gcatcttgtt cgaaaaaccg   6300

acgattcagg aactggcggc gttcatcgaa gagacagcca aagggaatgt cttctcgatc   6360

gagcctgtgc aaaagcaagc gtactatccg gtctcctcgg cacaaaagcg catgtacatc   6420

ctcgatcaat ttgagggagt cggcatcagc tacaacatgc cgtcgactat gctgatcgaa   6480

ggcaagctgg agcgaacacg ggtagaagcg gcgttccagc gcttgattgc gcgacatgaa   6540

agcctgcgca cttcgtttgc cgtcgtcaac ggagagcctg tgcaaaacat tcacgaggac   6600

gttccgtttg cgcttgccta ttcggaagtc acagaacagg aggcgcgcga actcgtttct   6660

tctctcgtgc agccgttcga tctggaggtc gcaccactca tccgcgtgtc gctgctgaaa   6720

atcggcgagg atcgttacgt gctctttacc gacatgcatc acagcatttc cgatggcgta   6780

tcctccggca ttcttttggc agagtgggtg cagctgtacc agggtgacgt tttgccggag   6840

ctgcgtatcc agtacaagga ctttgctgtg tggcaacaag agttttccca gtcggctgcc   6900

ttccacaagc aggaagcgta ctggttgcaa acgtttgccg atgacattcc tgtgctgaac   6960

ttgccgaccg atttcacccg ccccagcacc caaagctttg ccggggatca gtgcacgatc   7020

ggcgcgggca aagcgctcac ggaaggcttg caccagttgg cgcaggcgac gggaacgact   7080

ttgtacatgg ttttgctcgc cgcgtacaac gtgctgctcg ccaagtatgc cgggcaggag   7140

gacatcatcg tcggcacgcc gattacaggc agatcccatg ccgatctcga accgatcgtc   7200

ggcatgttcg tgaacacctt ggcgatgcga aacaaaccgc agcgcgaaaa gacttttagc   7260

gagtttttgc aagaagtcaa gcaaaatgcg ctggatgcgt acggccatca ggattacccg   7320

tttgaagaac tggtggaaaa gctcgcgatc gcgcgcgatt tgagccgaaa tccgctgttt   7380

gacaccgtgt ttacgttcca aaacagcacg gaagaggtca tgacgctgcc tgaatgcacg   7440

cttgcgccgt ttatgacgga cgaaacaggc cagcacgcca agttcgactt gactttcagc   7500

gctacggaag agcgggaaga aatgacgatt ggcgtggagt acagcacaag cttgtttacg   7560

cgggaaacga tggaacggtt cagccgccac ttcctgacga ttgcagcgag catcgtgcaa   7620

aatccgcaca tccgtctggg cgagatcgac atgcttttgc cagaagaaaa acagcagatt   7680

ttggccgggt tcaacgatac ggcagtcagc tatgcgctgg acaaaacgct gcaccagcta   7740

ttcgaagagc aggtcgacaa aacaccggat caggcagcgc ttctctttag cgagcaatcg   7800

ctgacgtaca gcgaactgaa cgagcgagca aacagactgg caagggtcct gcgcgcaaaa   7860

ggagtcggac cggaccgtct ggtagcgatc atggcggagc gctcgccgga aatggtgatc   7920

ggtattctcg gtattttgaa ggcaggcggc gcttatgttc ccgtcgatcc cggctatccg   7980

caggagcgca ttcagtacct gctcgaagat agcaacgcag ccctgctgct cagccaggcg   8040

catctgttgc cgctgttggc ccaggtgtca agcgagctgc cggagtgcct tgatctgaac   8100

gctgaactgg atgccggact gagcggctcc aacctgccag ctgtcaacca accgactgac   8160

cttgcctacg tcatctatac atccggtacg accggcaagc cgaagggtgt catgatcccg   8220

catcaaggaa tcgtgaactg cttgcagtgg agaagagacg aatacgggtt cgggccgagt   8280

gacaaggcgt tgcaagtgtt ctcctttgcc ttcgacggtt ttgtagccag cttgttcgct   8340

ccgctgctcg gaggggcaac gtgcgtgttg ccgcaagaag cagctgccaa agacccggtc   8400

gcgctgaaaa aactgatggc cgcaacggaa gtcacccatt actacggcgt accgagtctg   8460

ttccaggcca ttctcgattg ctcgacgaca accgacttca atcagttgcg ttgcgtcact   8520

ttgggcggcg agaagctgcc tgtgcagctt gtgcaaaaaa caaaagaaaa gcatccggca   8580

atcgagatca acaacgagta cggcccgacg gaaaacagcg tcgtcaccac catctcgcgc   8640

tcgattgaag cggggcaagc gatcacgatt ggccgaccgc ttgcgaacgt ccaagtctac   8700

attgtagatg agcagcatca cttgcagccg attggcgtgg tcggtgagct gtgcatcggc   8760

ggagccgggc ttgccagagg ctatctgaac aaaccggagc tgaccgcaga gaagtttgtc   8820

gcaaatccgt tccgaccagg cgagcgcatg tacaaaacag gcgacttggt aaaatggcgg   8880

acggatggca cgatcgagta catcggccgc gcagacgaac aggtcaaggt gagagggtat   8940

cgcatcgaga tcggcgagat cgagagcgcc gtactcgctt accagggcat cgatcaagcg   9000

gtggtcgttg cgcgagacga tgacgctacg gctggttcct atctttgcgc ctactttgtc   9060

gcagcaacag ccgtgtccgt atccggcttg agaagccatc tggccaaaga gctgcctgct   9120

tacatgattc cgagctattt cgtcgagctg gatcagctgc cgctttccgc caatggaaaa   9180

gtggatcgca aagctttgcc gaagccgcaa cagtccgatg cgaccacgcg cgaatacgtg   9240

gccccgagga atgcgaccga acagcaactg gcagccatct ggcaagaagt tttgggagta   9300

gagccaatcg gcatcaccga ccagttcttt gaactcggag gacattcctt aaaagctacg   9360

ctgttgattg ccaaagtgta tgagtacatg caaatcgagc tgccgctgaa tctcatcttc   9420

cagtatccga cgatcgaaaa ggtggccgat ttcatcacga cgagcggaaa agagacgtat   9480

gtgccgatcg agcctgcacc gttgcaagag tattatcctg tttcatctgc gcaaaagcgg   9540

atgtatgtcc tgcgccagtt tgcggacaca ggcacggttt ataacatgcc gagcgcgttg   9600

tatatcgaag gcgatctgga tcggaagcgt tttgaagccg ccatccacgg attggtcgag   9660

cggcacgaat cgctgcgcac atccttccac accgtaaatg gcgagcctgt ccagcgcgta   9720

cacgagcatg tcgagctgaa tgtgcagtac gcggaagtga cggaagcgca agtggagcca   9780

accgtcgagt cgttcgtgca agcatttgat ctgacaaaag ctccgctatt gcgggtcgga   9840

cttttcaagc tggcagcgaa acggcatctg ttcctgctgg atatgcatca catcatctcg   9900

gatggcgtct cggccggaat cattatggaa gagttctcga agctgtatcg aggcgaagaa   9960

ctgcctgcgc tttccgtcca ttacaaagat ttcgccgtct ggcagtctga actgttccag  10020

agcgacgtct ataccgagca tgaaaactac tggctgaacg cgttttctgg cgacattccg  10080

gtgcttaact tgccagccga tttttctcgt ccgctgacac agagctttga aggagattgc  10140

gtttcgttcc aggcagacaa agcgttgctg gacgatcttc acaagctcgc tcaggagagc  10200

caatcgacgt tgttcatggt attgctggcg gcttacaatg tgctgcttgc caagtacagc  10260

ggacaggaag acatcgtcgt cggcacaccg attgcgggca gatcgcacgc cgatatcgag  10320

aacgttctgg ggatgtttgt caacacgctc gctttgcgca actatccggt cgagacgaaa  10380

cacttccagg catttttgga agaggtcaag caaaatacgc tgcaagcata cgcccatcaa  10440

gattatccgt tcgaagcact ggtcgaaaag ctggacatcc agcgggatct cagccgcaat  10500

ccgctgtttg acaccatgtt tattttgcaa aacctggacc aaaaagctta cgagctggat  10560

gggctgaaac tggaggcata tccggcacaa gcaggcaacg ccaaattcga tctcacgctg  10620

gaagcgcacg aggacgagac aggcattcat tttgcgctcg tctactcgac caaattgttc  10680

cagcgagaat caatcgaaag aatggcgggt cacttcctgc aagtgctgcg ccaagtcgtt  10740

gccgaccaag caactgcctt gcgcgagatc agcctgctca gcgaggaaga gcgccgaatt  10800

gtgaccgttg atttcaacaa cacgtttgcc tatccgcgcg atctgacgat tcaggagctg  10860

ttcgagcagc aggcagcaaa aactccggag catgcagcgg tcgtgatgga cggacagatg  10920

ctgacgtatc gggagctgaa cgaaaaagcg aaccagctcg cccatgtcct tcgtcaaaac  10980

ggagtcggga aagagagcat cgtcggtctg ctcgcagatc gttcgctgga aatgattaca  11040

ggcatcatgg ggattctcaa agcgggcggc gcctacctgg gactggaccc ggagcatccg  11100

tccgaacgcc tggcttacat gttggaagat ggcggcgtga aagttgtcct cgtgcaaaag  11160

cacttgctgc cgctcgtcgg cgaagggctg atgccaatcg ttttggaaga ggagagcctg  11220

cgcccggaag attgcggcaa tccggcgatt gtcaacggtg cgagtgacct ggcttatgtg  11280

atgtacacct caggctctac aggcaagcca aaaggagtca tggtcgagca tcgcaacgtc  11340

acccgcttgg tcatgcatac gaattacgtg caagtgcgcg agagcgaccg gatgattcaa  11400

accggcgcga ttggcttcga cgccatgaca tttgagattt ttggagcctt gctgcacggg  11460

gccagcctgt atttggtgag caaggacgtc ttgctggatg ccgaaaagct gggcgacttc  11520

ctgcggacga atcagattac gaccatgtgg ctgacctcgc cgctcttcaa ccagctttcg  11580

caagacaatc cggcgatgtt tgacagcttg cgcgccttga tcgtcggtgg cgaagcgttg  11640

tcgccgaagc acatcaaccg ggtaaaaagt gcccttcctg acctggaaat ctggaacgga  11700

tacggcccga ccgaaaacac gaccttctcg acgtgctatt tgattgagca gcattttgaa  11760

gagcagattc cgatcggcaa gccgattgca aactccaccg cgtatatcgt cgacggcaac  11820

aatcagccgc agccgatcgg cgtaccgggt gaactgtgcg tcggtggtga cggtgtcgca  11880

agaggctatg tgaacaagcc ggaattaacc gccgaaaagt ttgtgcccaa tccgtttgcg  11940

cctggcgaaa cgatgtatcg caccggagat ttggcgagat ggctgccgga tgggacgatt  12000

gagtatttgg gccgaatcga ccagcaggtc aaaatcaggg gataccggat cgagcttggg  12060

gaaatcgaga cggtcttgtc ccagcaggca caagtaaaag aagcagtcgt ggccgtgatc  12120

gaggaggcga acgggcaaaa agctctctgc gcttactttg tgccagaaca ggccgtcgac  12180

gccgcagagc tgcgagaagc gatgtccaaa caattgcctg gctacatggt ccctgcttac  12240

tatgtgcaaa tggaaaagct gccgttgacc gcgaacggaa aggtcgaccg ccgggcattg  12300

ccgcagccat ccggcgagcg gacgacagga agcgcctttg tcgctgcgca aaatgatacc  12360

gaagcgaagc tgcaacagat ttggcaagaa gttttgggca ttccggcaat cggcattcac  12420

gacaacttct ttgaaatcgg cggtcattcc ttgaaggcga tgaacgtcat cacgcaagtc  12480

cataaaacat tccaggtgga gctgccgtta aaagcgctgt ttgccactcc gacgatccat  12540

gagttggctg cgcatatttc ggaaaaaacc gagtacaccg cgattcaacc cgtggcagcg  12600

caggagtttt acccggtttc atctgcgcaa aaaagaatgt atatcctgca acagttcgaa  12660

ggcaacggaa tcagctacaa catttcgggt gcgattctcc tggaaggaaa gctggactac  12720

gcccggtttg ccagcgctgt gcaacagctg gcagagcgcc acgaagcttt gcgcacctcg  12780

ttccaccgga tcgacggcga gcctgtgcaa aaagtgcacg aggaagtaga agtgccgctt  12840

ttcatgctgg aggctcccga agaccaggcg gagaaaatca tgcgcgagtt tgtccgtccg  12900

tttgatctcg gggtcgctcc gctgatgcga acaggtttgc tcaagctggg caaagaccgc  12960

catttgtttt tgctcgacat gcaccatatc atctcggacg gcgtttcttc gcaaattttg  13020

ctgcgtgaat ttgccgagtt gtaccaggga gcagacttgc agccgctttc gctgcaatac  13080

aaagatttcg ctgcttggca aaatgagctg tttcagacgg aggcatacaa gaagcaggag  13140

cagcactggc tgaacacgtt tgctgatgaa attccgctct tgaacctgcc gactgactat  13200

ccgcgcccta gcgtgcaaag ctttgcaggc gatctcgtcc tttttgccgc cggaaaagaa  13260

ctgctggagc ggttgcaaca ggtagcgtca gaaacaggca ccaccttgta catgattttg  13320

cttgccgcct acaatgtgct gctgtccaag tataccggcc aggaagacat catcgtcggg  13380

acgcctgtcg ctggacgttc ccatgcggac gtggaaaaca tcatgggcat attcgtgaac  13440

acattggcgc tgcgcaacca gcctgccagc agcaaaacga tgttagaaaa taatattaca  13500

caatgtgact caatcaatga tgtttatctt aaagaagaag caataacatt gatggatatg  13560

cttgagagtc aacttaagca ccaggcagat ggatatgttg ttattgatca agaagaatct  13620

ctcagttacg ctgatttcta tttgagggtg aaagagatag ggtattgtct gtcagaaatt  13680

agctcaaaga attcggtggg tattgggctt ttttgtgatc cttctataga tttaatttgt  13740

ggtgcatggg gtattttgtc agcggataaa gcttatttgc cgttatcgcc tgactatcca  13800

actgaacgcc tcaaatatat gatagaagat tctggtattg atgtgatttt tacgcaatcg  13860

cacttaaaag cacagctaca ggacattgca ccaaaatcag tattaattat gacaccagaa  13920

gatgtcgctc tgacgataaa aacacgaaca atagaagata ttctgggcac agttcaagtt  13980

cctaaaccca ctagtctggc ttatattatt tatacctctg gtagcacggg taagccaaag  14040

ggagtgatga ttgaacatca cagtattgta aatcaaatga gatttcttgc aaaagcgttc  14100

aaattaggat gtcattcccg gattttacag aaaacaccaa tgagttttga tgcggctcaa  14160

tgggaaattc tagcgcctgc aattggtggt caagtgatta tgggtccttt aggttgctat  14220

cgcgatccgg atgcaattat taaaaccatt cttcagcatc aagtaacgac tttgcaatgt  14280

gttcctactt tgctacaagc gttactggat aatcctaatt ttttggattg cttatcattg  14340

actcaagtat tcagtggggg agaagcgctg acaaccaaat tagccacgca atttttgaat  14400

agttttactc actgtgaatt aatcaattta tatggcccga cagaatgtac gattaattca  14460

tcatttttcc gggtgacaaa tgagactttg ccgaattatc aaacctctat ttcgattggt  14520

gcacctgtag ataataccga atactacgtt cttgatgatg atagattacc tgtggcggtt  14580

ggcgaaattg gcgagcttta tatttcgggt gctcaattag cacgtggtta tttgcataaa  14640

ccagaaatga caaaagataa atttatttgt aatcaccttg tatcaggaac tcaacatcaa  14700

tggttatatc gaacgggaga tctggtaacc agaggggctg atggtaatac ttattttgtt  14760

ggtcgggttg atagccaggt caaattacga ggttaccgta ttgagcttga tgaaatacgc  14820

catgcgattg aagaacatag ctggataaag acggcggcaa tgttaattaa gaaggatgcc  14880

agaacgggtt tccaaaatct catcgcgtgt gtggaattag atgagaaaga agctgcattg  14940

atggatcaag gtaatagtag ctcacatcac aaatcaaaag ccgataaact acaggtgaaa  15000

gcccaacttt ctaattctgg ttgtcgaagt gaagagttat gtgaaaatcg ccctacattc  15060

ttacttcctt atcaagaagg ggagataaaa cagagagaat atgcatttgg acgcaagaca  15120

tatcgctatt ttgagggaac agaaataacg gtagagaaat taaaaaaatt gctgacagcc  15180

actcaatcga atgaaattag ctctttgcca ctgagtcatc taaccctgaa tgatttcggt  15240

tatgcattgc gttattttgg tcagtttacc agccatcaac gtttattgcc caaatatgcc  15300

tatgcttcac cgggtgctct ctatgcgaca caaatgtatt ttgaattgca taatgttctc  15360

ggtttggatg cggggattta ctattatcat ccagtgacac ataagttaat aaaaatttca  15420

acattgagtc gtcggcaaat gccaacgata aaagtgcatt ttattggcaa gcatgaagcc  15480

attgagcccg tttataagaa caatatacaa gaagttctgg aaatggaagc gggccatatg  15540

atgggtcttt ttgatgacgt attaccggaa attggcttga gtattggtaa aagtgaatat  15600

caagatgaat gtccagattg gtatgatggt gatattcagg attattatct tggtgcattt  15660

gaaatatgta gctatgaaca tggattgccg ccatttgaga ctgatattta tttacaaaca  15720

catgcccata aaatacctga gatgccgtgt ggtttatatc acttttctaa cggggaattt  15780

gtacgaataa gtgatgatat tgtccgaaaa aaggatgtta ttgcgattaa tcagcaagtt  15840

tatgatcgct ccagttttgg cgtgtcaatt attccacgct gtgtccctga atggcattat  15900

tatataacac tgggtcgtcg gttacatgcg ttacaaagta atccattgta tattggatta  15960

atgtcatctg gttacagttc gaagagcaat aacgatttac cttcggcgaa aaggatgcga  16020

tctattctca atgcacttga tagacctatg gcggcatttt atttctgcat aggtgggggt  16080

attagccaag cgcaatatat gtgtgaaggc atgaaagaag atgttgttca tatgaaaggg  16140

ccagttgaaa tcattaaaga tgatcttcaa caacaactcc ctcaatatat gattccaaat  16200

aaggtattag ttttcgataa attacctttg acggccaatg gaaaagtgga ttatcaatct  16260

ttatcagaat ctaaagccgt ggagaatgtt tcaacacagc gtctattggt gccattacat  16320

acagatactg aaataaggct tggaaaaatt tggatggaag tactgaaatg ggattcagta  16380

tctgccctcg atgatttttt cgaaagtggg ggtaattctt tgatggccgt tgcaatggtt  16440

aataagatca atgcggcctt taatattcgt tttccgttac agatactttt tcaatctcct  16500

aatatagcag aattggctaa gtggattgaa cagacagact ctaaaacaat atcaagatta  16560

attttattga atcaggcaag caaagacccc atttactgtt ggccgggttt gggcggatat  16620

cctatgagtt tgagattgct tgctaataaa gtcgttcctg atcgggcatt ttatggaata  16680

caggcatatg ggataaacga gagtgaaata ccgttttctt ctatccagag aatggcagaa  16740

gaggatatta aagagataaa gaaaatacag ccagaagggc catatatatt gtggggatat  16800

tcatttggtg cccgagtagc atttgaagtt gcataccagc ttgaacaagc gggagaagaa  16860

gttaacgcat tgaatttatt ggctccggga tctcctcatc ttgatatgaa gcaagcggaa  16920

tatatggata aaggcgctga atttactaat ccggcttttg ttaaaatact tttttctgta  16980

ttttctcgtt caatcaacag cccaatggtt aaaacttgct tagaacaagt aaatagtgaa  17040

acgacattta ttaactttat atgtagtcgt tttaaaaact tggaaccatc attagtaaaa  17100

cgtatcgtta ggattgtgac tttgacttat gatttcaagt acagtattga tgagctttat  17160

cacagacacc taaaggcacc tataactatt ttcaaggcga atagagataa tgattcattt  17220

atcgaggaat cggatgtgat ttcatcaatg tcgcctaaaa taattgaatt aatatcggat  17280

cactatcaac tgttggaaag tgaaggtgtt gctgagattg agaaaataat ctaa        17334


<210>  18
<211>  9756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Indigoidine-tagged Dipeptide consisting of 
       Proline and Leucine

<400>  18
atggattgcg tggcaaacaa ttcgggagtc gagctttgcc agattccgtt gctgacagaa     60

gcagaaacta gccagctgtt ggcaaagcgt acggaaacag cggctgacta tcctgccgca    120

accatgcacg agctgttttc gcggcaggca gaaaaaacgc ctgagcaagt ggcggtagtc    180

ttcgcggatc agcacctgac gtatcgggag ctggatgaaa aatccaatca gctcgcccgc    240

tttttgcgca aaaaaggcat tggcacgggc agtcttgtcg gcacgctgct ggatcgctcg    300

ctggacatga tcgtcggaat cctcggcgtc ttgaaggcag gcggcgcatt tgtgccgatc    360

gacccggagt tgcctgccga acgaatcgct tacatgctga cgcatagcag agttccattg    420

gtcgtgacgc aaaatcattt gcgggcaaaa gtgaccacgc ctacagaaac aattgacatc    480

aacacagcgg tgatcgggga agagagccgc gcccctatcg aatcgctcaa tcagccgcat    540

gacttgtttt acatcatcta tacgtccgga acgacagggc aaccgaaagg cgtcatgctg    600

gagcatcgca acatggcgaa cctgatgcat tttacgtttg atcagacgaa catcgctttt    660

catgaaaaag tgttgcagta taccacgtgc agctttgatg tttgctacca ggaaattttc    720

tccacgctgc tatccggggg ccagctctac ctgatcacga acgagctgag acggcatgtg    780

gaaaagctgt ttgctttcat ccaggaaaag cagatcagca ttttgtctct cccggtgtcc    840

ttcctgaaat ttatttttaa cgaacaagac tacgcgcaaa gcttcccgcg ttgtgtcaaa    900

catatcatca cggccgggga acaactcgtc gtcacacacg agctgcaaaa gtatctgcgc    960

cagcatcgcg tatttttgca caatcactac ggcccgtcgg agacgcatgt ggtgacgaca   1020

tgcacgatgg acccgggaca ggcgatacca gagctgccgc ccatcggaaa gccgatcagc   1080

aacacaggca tttacatttt ggatgaaggg ctgcaattga agccggaggg gatcgtcggg   1140

gagttgtaca tttccggcgc aaacgtagga agagggtatt tgcaccagcc ggagctgacc   1200

gcggagaagt ttctcgacaa tccgtatcag ccaggcgaaa gaatgtaccg aacgggtgat   1260

ctggcccttt ggttgccgga tggccagctc gaatttttgg gccgaatcga ccatcaggta   1320

aaaatcaggg gccatcgcat cgagctggga gagatcgaat cgcgcctgct caaccatccc   1380

gccatcaagg aagcggtggt tatcgaccga gcagacgaga caggcggcaa gtttttgtgc   1440

gcctatgtcg tcctgcaaaa agcgctcagc gacgaagaga tgcgggcata cttggcgcaa   1500

gcgttgccgg agtatatgat cccttccttt ttcgtgacgc tggagcggat tccagtcacg   1560

ccgaacggaa aaacagacag gcgagctttg ccgaagccgg aaggaagtgc caagacgaaa   1620

gcggattacg tcgccccgac gactgagctg gaacaaaagc tggtcgcgat ttgggagcaa   1680

attcttggcg tgtcgccgat cggcattcag gatcattttt tcacgctggg cggccattcg   1740

ttaaaagcga ttcagctcat ttcccgcatc caaaaggaat gccaggcgga tgtcccgctg   1800

cgcgtcctgt ttgagcaacc gacgattcaa gcgctggcag cgtatgtgga aggcggggag   1860

gaagggaatg tcttctcgat cgagcctgtg caaaagcaag cgtactatcc ggtctcctcg   1920

gcacaaaagc gcatgtacat cctcgatcaa tttgagggag tcggcatcag ctacaacatg   1980

ccgtcgacta tgctgatcga aggcaagctg gagcgaacac gggtagaagc ggcgttccag   2040

cgcttgattg cgcgacatga aagcctgcgc acttcgtttg ccgtcgtcaa cggagagcct   2100

gtgcaaaaca ttcacgagga cgttccgttt gcgcttgcct attcggaagt cacagaacag   2160

gaggcgcgcg aactcgtttc ttctctcgtg cagccgttcg atctggaggt cgcaccactc   2220

atccgcgtgt cgctgctgaa aatcggcgag gatcgttacg tgctctttac cgacatgcat   2280

cacagcattt ccgatggcgt atcctccggc attcttttgg cagagtgggt gcagctgtac   2340

cagggtgacg ttttgccgga gctgcgtatc cagtacaagg actttgctgt gtggcaacaa   2400

gagttttccc agtcggctgc cttccacaag caggaagcgt actggttgca aacgtttgcc   2460

gatgacattc ctgtgctgaa cttgccgacc gatttcaccc gccccagcac ccaaagcttt   2520

gccggggatc agtgcacgat cggcgcgggc aaagcgctca cggaaggctt gcaccagttg   2580

gcgcaggcga cgggaacgac tttgtacatg gttttgctcg ccgcgtacaa cgtgctgctc   2640

gccaagtatg ccgggcagga ggacatcatc gtcggcacgc cgattacagg cagatcccat   2700

gccgatctcg aaccgatcgt cggcatgttc gtgaacacct tggcgatgcg aaacaaaccg   2760

cagcgcgaaa agacttttag cgagtttttg caagaagtca agcaaaatgc gctggatgcg   2820

tacggccatc aggattaccc gtttgaagaa ctggtggaaa agctcgcgat cgcgcgcgat   2880

ttgagccgaa atccgctgtt tgacaccgtg tttacgttcc aaaacagcac ggaagaggtc   2940

atgacgctgc ctgaatgcac gcttgcgccg tttatgacgg acgaaacagg ccagcacgcc   3000

aagttcgact tgactttcag cgctacggaa gagcgggaag aaatgacgat tggcgtggag   3060

tacagcacaa gcttgtttac gcgggaaacg atggaacggt tcagccgcca cttcctgacg   3120

attgcagcga gcatcgtgca aaatccgcac atccgtctgg gcgagatcga catgcttttg   3180

ccagaagaaa aacagcagat tttggccggg ttcaacgata cggcagtcag ctatgcgctg   3240

gacaaaacgc tgcaccagct attcgaagag caggtcgaca aaacaccgga tcaggcagcg   3300

cttctcttta gcgagcaatc gctgacgtac agcgaactga acgagcgagc aaacagactg   3360

gcaagggtcc tgcgcgcaaa aggagtcgga ccggaccgtc tggtagcgat catggcggag   3420

cgctcgccgg aaatggtgat cggtattctc ggtattttga aggcaggcgg cgcttatgtt   3480

cccgtcgatc ccggctatcc gcaggagcgc attcagtacc tgctcgaaga tagcaacgca   3540

gccctgctgc tcagccaggc gcatctgttg ccgctgttgg cccaggtgtc aagcgagctg   3600

ccggagtgcc ttgatctgaa cgctgaactg gatgccggac tgagcggctc caacctgcca   3660

gctgtcaacc aaccgactga ccttgcctac gtcatctata catccggtac gaccggcaag   3720

ccgaagggtg tcatgatccc gcatcaagga atcgtgaact gcttgcagtg gagaagagac   3780

gaatacgggt tcgggccgag tgacaaggcg ttgcaagtgt tctcctttgc cttcgacggt   3840

tttgtagcca gcttgttcgc tccgctgctc ggaggggcaa cgtgcgtgtt gccgcaagaa   3900

gcagctgcca aagacccggt cgcgctgaaa aaactgatgg ccgcaacgga agtcacccat   3960

tactacggcg taccgagtct gttccaggcc attctcgatt gctcgacgac aaccgacttc   4020

aatcagttgc gttgcgtcac tttgggcggc gagaagctgc ctgtgcagct tgtgcaaaaa   4080

acaaaagaaa agcatccggc aatcgagatc aacaacgagt acggcccgac ggaaaacagc   4140

gtcgtcacca ccatctcgcg ctcgattgaa gcggggcaag cgatcacgat tggccgaccg   4200

cttgcgaacg tccaagtcta cattgtagat gagcagcatc acttgcagcc gattggcgtg   4260

gtcggtgagc tgtgcatcgg cggagccggg cttgccagag gctatctgaa caaaccggag   4320

ctgaccgcag agaagtttgt cgcaaatccg ttccgaccag gcgagcgcat gtacaaaaca   4380

ggcgacttgg taaaatggcg gacggatggc acgatcgagt acatcggccg cgcagacgaa   4440

caggtcaagg tgagagggta tcgcatcgag atcggcgaga tcgagagcgc cgtactcgct   4500

taccagggca tcgatcaagc ggtggtcgtt gcgcgagacg atgacgctac ggctggttcc   4560

tatctttgcg cctactttgt cgcagcaaca gccgtgtccg tatccggctt gagaagccat   4620

ctggccaaag agctgcctgc ttacatgatt ccgagctatt tcgtcgagct ggatcagctg   4680

ccgctttccg ccaatggaaa agtggatcgc aaagctttgc cgaagccgca acagtccgat   4740

gcgaccacgc gcgaatacgt ggccccgagg aatgcgaccg aacagcaact ggcagccatc   4800

tggcaagaag ttttgggagt agagccaatc ggcatcaccg accagttctt tgaactcgga   4860

ggacattcct taaaagctac gctgttgatt gccaaagtgt atgagtacat gcaaatcgag   4920

ctgccgctga atctcatctt ccagtatccg acgatcgaaa aggtggccga tttcatcacg   4980

tcggaaaaaa ccgagtacac cgcgattcaa cccgtggcag cgcaggagtt ttacccggtt   5040

tcatctgcgc aaaaaagaat gtatatcctg caacagttcg aaggcaacgg aatcagctac   5100

aacatttcgg gtgcgattct cctggaagga aagctggact acgcccggtt tgccagcgct   5160

gtgcaacagc tggcagagcg ccacgaagct ttgcgcacct cgttccaccg gatcgacggc   5220

gagcctgtgc aaaaagtgca cgaggaagta gaagtgccgc ttttcatgct ggaggctccc   5280

gaagaccagg cggagaaaat catgcgcgag tttgtccgtc cgtttgatct cggggtcgct   5340

ccgctgatgc gaacaggttt gctcaagctg ggcaaagacc gccatttgtt tttgctcgac   5400

atgcaccata tcatctcgga cggcgtttct tcgcaaattt tgctgcgtga atttgccgag   5460

ttgtaccagg gagcagactt gcagccgctt tcgctgcaat acaaagattt cgctgcttgg   5520

caaaatgagc tgtttcagac ggaggcatac aagaagcagg agcagcactg gctgaacacg   5580

tttgctgatg aaattccgct cttgaacctg ccgactgact atccgcgccc tagcgtgcaa   5640

agctttgcag gcgatctcgt cctttttgcc gccggaaaag aactgctgga gcggttgcaa   5700

caggtagcgt cagaaacagg caccaccttg tacatgattt tgcttgccgc ctacaatgtg   5760

ctgctgtcca agtataccgg ccaggaagac atcatcgtcg ggacgcctgt cgctggacgt   5820

tcccatgcgg acgtggaaaa catcatgggc atattcgtga acacattggc gctgcgcaac   5880

cagcctgcca gcagcaaaac gatgttagaa aataatatta cacaatgtga ctcaatcaat   5940

gatgtttatc ttaaagaaga agcaataaca ttgatggata tgcttgagag tcaacttaag   6000

caccaggcag atggatatgt tgttattgat caagaagaat ctctcagtta cgctgatttc   6060

tatttgaggg tgaaagagat agggtattgt ctgtcagaaa ttagctcaaa gaattcggtg   6120

ggtattgggc ttttttgtga tccttctata gatttaattt gtggtgcatg gggtattttg   6180

tcagcggata aagcttattt gccgttatcg cctgactatc caactgaacg cctcaaatat   6240

atgatagaag attctggtat tgatgtgatt tttacgcaat cgcacttaaa agcacagcta   6300

caggacattg caccaaaatc agtattaatt atgacaccag aagatgtcgc tctgacgata   6360

aaaacacgaa caatagaaga tattctgggc acagttcaag ttcctaaacc cactagtctg   6420

gcttatatta tttatacctc tggtagcacg ggtaagccaa agggagtgat gattgaacat   6480

cacagtattg taaatcaaat gagatttctt gcaaaagcgt tcaaattagg atgtcattcc   6540

cggattttac agaaaacacc aatgagtttt gatgcggctc aatgggaaat tctagcgcct   6600

gcaattggtg gtcaagtgat tatgggtcct ttaggttgct atcgcgatcc ggatgcaatt   6660

attaaaacca ttcttcagca tcaagtaacg actttgcaat gtgttcctac tttgctacaa   6720

gcgttactgg ataatcctaa ttttttggat tgcttatcat tgactcaagt attcagtggg   6780

ggagaagcgc tgacaaccaa attagccacg caatttttga atagttttac tcactgtgaa   6840

ttaatcaatt tatatggccc gacagaatgt acgattaatt catcattttt ccgggtgaca   6900

aatgagactt tgccgaatta tcaaacctct atttcgattg gtgcacctgt agataatacc   6960

gaatactacg ttcttgatga tgatagatta cctgtggcgg ttggcgaaat tggcgagctt   7020

tatatttcgg gtgctcaatt agcacgtggt tatttgcata aaccagaaat gacaaaagat   7080

aaatttattt gtaatcacct tgtatcagga actcaacatc aatggttata tcgaacggga   7140

gatctggtaa ccagaggggc tgatggtaat acttattttg ttggtcgggt tgatagccag   7200

gtcaaattac gaggttaccg tattgagctt gatgaaatac gccatgcgat tgaagaacat   7260

agctggataa agacggcggc aatgttaatt aagaaggatg ccagaacggg tttccaaaat   7320

ctcatcgcgt gtgtggaatt agatgagaaa gaagctgcat tgatggatca aggtaatagt   7380

agctcacatc acaaatcaaa agccgataaa ctacaggtga aagcccaact ttctaattct   7440

ggttgtcgaa gtgaagagtt atgtgaaaat cgccctacat tcttacttcc ttatcaagaa   7500

ggggagataa aacagagaga atatgcattt ggacgcaaga catatcgcta ttttgaggga   7560

acagaaataa cggtagagaa attaaaaaaa ttgctgacag ccactcaatc gaatgaaatt   7620

agctctttgc cactgagtca tctaaccctg aatgatttcg gttatgcatt gcgttatttt   7680

ggtcagttta ccagccatca acgtttattg cccaaatatg cctatgcttc accgggtgct   7740

ctctatgcga cacaaatgta ttttgaattg cataatgttc tcggtttgga tgcggggatt   7800

tactattatc atccagtgac acataagtta ataaaaattt caacattgag tcgtcggcaa   7860

atgccaacga taaaagtgca ttttattggc aagcatgaag ccattgagcc cgtttataag   7920

aacaatatac aagaagttct ggaaatggaa gcgggccata tgatgggtct ttttgatgac   7980

gtattaccgg aaattggctt gagtattggt aaaagtgaat atcaagatga atgtccagat   8040

tggtatgatg gtgatattca ggattattat cttggtgcat ttgaaatatg tagctatgaa   8100

catggattgc cgccatttga gactgatatt tatttacaaa cacatgccca taaaatacct   8160

gagatgccgt gtggtttata tcacttttct aacggggaat ttgtacgaat aagtgatgat   8220

attgtccgaa aaaaggatgt tattgcgatt aatcagcaag tttatgatcg ctccagtttt   8280

ggcgtgtcaa ttattccacg ctgtgtccct gaatggcatt attatataac actgggtcgt   8340

cggttacatg cgttacaaag taatccattg tatattggat taatgtcatc tggttacagt   8400

tcgaagagca ataacgattt accttcggcg aaaaggatgc gatctattct caatgcactt   8460

gatagaccta tggcggcatt ttatttctgc ataggtgggg gtattagcca agcgcaatat   8520

atgtgtgaag gcatgaaaga agatgttgtt catatgaaag ggccagttga aatcattaaa   8580

gatgatcttc aacaacaact ccctcaatat atgattccaa ataaggtatt agttttcgat   8640

aaattacctt tgacggccaa tggaaaagtg gattatcaat ctttatcaga atctaaagcc   8700

gtggagaatg tttcaacaca gcgtctattg gtgccattac atacagatac tgaaataagg   8760

cttggaaaaa tttggatgga agtactgaaa tgggattcag tatctgccct cgatgatttt   8820

ttcgaaagtg ggggtaattc tttgatggcc gttgcaatgg ttaataagat caatgcggcc   8880

tttaatattc gttttccgtt acagatactt tttcaatctc ctaatatagc agaattggct   8940

aagtggattg aacagacaga ctctaaaaca atatcaagat taattttatt gaatcaggca   9000

agcaaagacc ccatttactg ttggccgggt ttgggcggat atcctatgag tttgagattg   9060

cttgctaata aagtcgttcc tgatcgggca ttttatggaa tacaggcata tgggataaac   9120

gagagtgaaa taccgttttc ttctatccag agaatggcag aagaggatat taaagagata   9180

aagaaaatac agccagaagg gccatatata ttgtggggat attcatttgg tgcccgagta   9240

gcatttgaag ttgcatacca gcttgaacaa gcgggagaag aagttaacgc attgaattta   9300

ttggctccgg gatctcctca tcttgatatg aagcaagcgg aatatatgga taaaggcgct   9360

gaatttacta atccggcttt tgttaaaata cttttttctg tattttctcg ttcaatcaac   9420

agcccaatgg ttaaaacttg cttagaacaa gtaaatagtg aaacgacatt tattaacttt   9480

atatgtagtc gttttaaaaa cttggaacca tcattagtaa aacgtatcgt taggattgtg   9540

actttgactt atgatttcaa gtacagtatt gatgagcttt atcacagaca cctaaaggca   9600

cctataacta ttttcaaggc gaatagagat aatgattcat ttatcgagga atcggatgtg   9660

atttcatcaa tgtcgcctaa aataattgaa ttaatatcgg atcactatca actgttggaa   9720

agtgaaggtg ttgctgagat tgagaaaata atctaa                             9756


<210>  19
<211>  12855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Valine-Indigoidine-tagged Dipeptide 
       consisting of Proline and Leucine. Valine is here used as spacer.

<400>  19
atggattgcg tggcaaacaa ttcgggagtc gagctttgcc agattccgtt gctgacagaa     60

gcagaaacta gccagctgtt ggcaaagcgt acggaaacag cggctgacta tcctgccgca    120

accatgcacg agctgttttc gcggcaggca gaaaaaacgc ctgagcaagt ggcggtagtc    180

ttcgcggatc agcacctgac gtatcgggag ctggatgaaa aatccaatca gctcgcccgc    240

tttttgcgca aaaaaggcat tggcacgggc agtcttgtcg gcacgctgct ggatcgctcg    300

ctggacatga tcgtcggaat cctcggcgtc ttgaaggcag gcggcgcatt tgtgccgatc    360

gacccggagt tgcctgccga acgaatcgct tacatgctga cgcatagcag agttccattg    420

gtcgtgacgc aaaatcattt gcgggcaaaa gtgaccacgc ctacagaaac aattgacatc    480

aacacagcgg tgatcgggga agagagccgc gcccctatcg aatcgctcaa tcagccgcat    540

gacttgtttt acatcatcta tacgtccgga acgacagggc aaccgaaagg cgtcatgctg    600

gagcatcgca acatggcgaa cctgatgcat tttacgtttg atcagacgaa catcgctttt    660

catgaaaaag tgttgcagta taccacgtgc agctttgatg tttgctacca ggaaattttc    720

tccacgctgc tatccggggg ccagctctac ctgatcacga acgagctgag acggcatgtg    780

gaaaagctgt ttgctttcat ccaggaaaag cagatcagca ttttgtctct cccggtgtcc    840

ttcctgaaat ttatttttaa cgaacaagac tacgcgcaaa gcttcccgcg ttgtgtcaaa    900

catatcatca cggccgggga acaactcgtc gtcacacacg agctgcaaaa gtatctgcgc    960

cagcatcgcg tatttttgca caatcactac ggcccgtcgg agacgcatgt ggtgacgaca   1020

tgcacgatgg acccgggaca ggcgatacca gagctgccgc ccatcggaaa gccgatcagc   1080

aacacaggca tttacatttt ggatgaaggg ctgcaattga agccggaggg gatcgtcggg   1140

gagttgtaca tttccggcgc aaacgtagga agagggtatt tgcaccagcc ggagctgacc   1200

gcggagaagt ttctcgacaa tccgtatcag ccaggcgaaa gaatgtaccg aacgggtgat   1260

ctggcccttt ggttgccgga tggccagctc gaatttttgg gccgaatcga ccatcaggta   1320

aaaatcaggg gccatcgcat cgagctggga gagatcgaat cgcgcctgct caaccatccc   1380

gccatcaagg aagcggtggt tatcgaccga gcagacgaga caggcggcaa gtttttgtgc   1440

gcctatgtcg tcctgcaaaa agcgctcagc gacgaagaga tgcgggcata cttggcgcaa   1500

gcgttgccgg agtatatgat cccttccttt ttcgtgacgc tggagcggat tccagtcacg   1560

ccgaacggaa aaacagacag gcgagctttg ccgaagccgg aaggaagtgc caagacgaaa   1620

gcggattacg tcgccccgac gactgagctg gaacaaaagc tggtcgcgat ttgggagcaa   1680

attcttggcg tgtcgccgat cggcattcag gatcattttt tcacgctggg cggccattcg   1740

ttaaaagcga ttcagctcat ttcccgcatc caaaaggaat gccaggcgga tgtcccgctg   1800

cgcgtcctgt ttgagcaacc gacgattcaa gcgctggcag cgtatgtgga aggcggggag   1860

gaagggaatg tcttctcgat cgagcctgtg caaaagcaag cgtactatcc ggtctcctcg   1920

gcacaaaagc gcatgtacat cctcgatcaa tttgagggag tcggcatcag ctacaacatg   1980

ccgtcgacta tgctgatcga aggcaagctg gagcgaacac gggtagaagc ggcgttccag   2040

cgcttgattg cgcgacatga aagcctgcgc acttcgtttg ccgtcgtcaa cggagagcct   2100

gtgcaaaaca ttcacgagga cgttccgttt gcgcttgcct attcggaagt cacagaacag   2160

gaggcgcgcg aactcgtttc ttctctcgtg cagccgttcg atctggaggt cgcaccactc   2220

atccgcgtgt cgctgctgaa aatcggcgag gatcgttacg tgctctttac cgacatgcat   2280

cacagcattt ccgatggcgt atcctccggc attcttttgg cagagtgggt gcagctgtac   2340

cagggtgacg ttttgccgga gctgcgtatc cagtacaagg actttgctgt gtggcaacaa   2400

gagttttccc agtcggctgc cttccacaag caggaagcgt actggttgca aacgtttgcc   2460

gatgacattc ctgtgctgaa cttgccgacc gatttcaccc gccccagcac ccaaagcttt   2520

gccggggatc agtgcacgat cggcgcgggc aaagcgctca cggaaggctt gcaccagttg   2580

gcgcaggcga cgggaacgac tttgtacatg gttttgctcg ccgcgtacaa cgtgctgctc   2640

gccaagtatg ccgggcagga ggacatcatc gtcggcacgc cgattacagg cagatcccat   2700

gccgatctcg aaccgatcgt cggcatgttc gtgaacacct tggcgatgcg aaacaaaccg   2760

cagcgcgaaa agacttttag cgagtttttg caagaagtca agcaaaatgc gctggatgcg   2820

tacggccatc aggattaccc gtttgaagaa ctggtggaaa agctcgcgat cgcgcgcgat   2880

ttgagccgaa atccgctgtt tgacaccgtg tttacgttcc aaaacagcac ggaagaggtc   2940

atgacgctgc ctgaatgcac gcttgcgccg tttatgacgg acgaaacagg ccagcacgcc   3000

aagttcgact tgactttcag cgctacggaa gagcgggaag aaatgacgat tggcgtggag   3060

tacagcacaa gcttgtttac gcgggaaacg atggaacggt tcagccgcca cttcctgacg   3120

attgcagcga gcatcgtgca aaatccgcac atccgtctgg gcgagatcga catgcttttg   3180

ccagaagaaa aacagcagat tttggccggg ttcaacgata cggcagtcag ctatgcgctg   3240

gacaaaacgc tgcaccagct attcgaagag caggtcgaca aaacaccgga tcaggcagcg   3300

cttctcttta gcgagcaatc gctgacgtac agcgaactga acgagcgagc aaacagactg   3360

gcaagggtcc tgcgcgcaaa aggagtcgga ccggaccgtc tggtagcgat catggcggag   3420

cgctcgccgg aaatggtgat cggtattctc ggtattttga aggcaggcgg cgcttatgtt   3480

cccgtcgatc ccggctatcc gcaggagcgc attcagtacc tgctcgaaga tagcaacgca   3540

gccctgctgc tcagccaggc gcatctgttg ccgctgttgg cccaggtgtc aagcgagctg   3600

ccggagtgcc ttgatctgaa cgctgaactg gatgccggac tgagcggctc caacctgcca   3660

gctgtcaacc aaccgactga ccttgcctac gtcatctata catccggtac gaccggcaag   3720

ccgaagggtg tcatgatccc gcatcaagga atcgtgaact gcttgcagtg gagaagagac   3780

gaatacgggt tcgggccgag tgacaaggcg ttgcaagtgt tctcctttgc cttcgacggt   3840

tttgtagcca gcttgttcgc tccgctgctc ggaggggcaa cgtgcgtgtt gccgcaagaa   3900

gcagctgcca aagacccggt cgcgctgaaa aaactgatgg ccgcaacgga agtcacccat   3960

tactacggcg taccgagtct gttccaggcc attctcgatt gctcgacgac aaccgacttc   4020

aatcagttgc gttgcgtcac tttgggcggc gagaagctgc ctgtgcagct tgtgcaaaaa   4080

acaaaagaaa agcatccggc aatcgagatc aacaacgagt acggcccgac ggaaaacagc   4140

gtcgtcacca ccatctcgcg ctcgattgaa gcggggcaag cgatcacgat tggccgaccg   4200

cttgcgaacg tccaagtcta cattgtagat gagcagcatc acttgcagcc gattggcgtg   4260

gtcggtgagc tgtgcatcgg cggagccggg cttgccagag gctatctgaa caaaccggag   4320

ctgaccgcag agaagtttgt cgcaaatccg ttccgaccag gcgagcgcat gtacaaaaca   4380

ggcgacttgg taaaatggcg gacggatggc acgatcgagt acatcggccg cgcagacgaa   4440

caggtcaagg tgagagggta tcgcatcgag atcggcgaga tcgagagcgc cgtactcgct   4500

taccagggca tcgatcaagc ggtggtcgtt gcgcgagacg atgacgctac ggctggttcc   4560

tatctttgcg cctactttgt cgcagcaaca gccgtgtccg tatccggctt gagaagccat   4620

ctggccaaag agctgcctgc ttacatgatt ccgagctatt tcgtcgagct ggatcagctg   4680

ccgctttccg ccaatggaaa agtggatcgc aaagctttgc cgaagccgca acagtccgat   4740

gcgaccacgc gcgaatacgt ggccccgagg aatgcgaccg aacagcaact ggcagccatc   4800

tggcaagaag ttttgggagt agagccaatc ggcatcaccg accagttctt tgaactcgga   4860

ggacattcct taaaagctac gctgttgatt gccaaagtgt atgagtacat gcaaatcgag   4920

ctgccgctga atctcatctt ccagtatccg acgatcgaaa aggtggccga tttcatcacg   4980

acgagcggaa aagagacgta tgtgccgatc gagcctgcac cgttgcaaga gtattatcct   5040

gtttcatctg cgcaaaagcg gatgtatgtc ctgcgccagt ttgcggacac aggcacggtt   5100

tataacatgc cgagcgcgtt gtatatcgaa ggcgatctgg atcggaagcg ttttgaagcc   5160

gccatccacg gattggtcga gcggcacgaa tcgctgcgca catccttcca caccgtaaat   5220

ggcgagcctg tccagcgcgt acacgagcat gtcgagctga atgtgcagta cgcggaagtg   5280

acggaagcgc aagtggagcc aaccgtcgag tcgttcgtgc aagcatttga tctgacaaaa   5340

gctccgctat tgcgggtcgg acttttcaag ctggcagcga aacggcatct gttcctgctg   5400

gatatgcatc acatcatctc ggatggcgtc tcggccggaa tcattatgga agagttctcg   5460

aagctgtatc gaggcgaaga actgcctgcg ctttccgtcc attacaaaga tttcgccgtc   5520

tggcagtctg aactgttcca gagcgacgtc tataccgagc atgaaaacta ctggctgaac   5580

gcgttttctg gcgacattcc ggtgcttaac ttgccagccg atttttctcg tccgctgaca   5640

cagagctttg aaggagattg cgtttcgttc caggcagaca aagcgttgct ggacgatctt   5700

cacaagctcg ctcaggagag ccaatcgacg ttgttcatgg tattgctggc ggcttacaat   5760

gtgctgcttg ccaagtacag cggacaggaa gacatcgtcg tcggcacacc gattgcgggc   5820

agatcgcacg ccgatatcga gaacgttctg gggatgtttg tcaacacgct cgctttgcgc   5880

aactatccgg tcgagacgaa acacttccag gcatttttgg aagaggtcaa gcaaaatacg   5940

ctgcaagcat acgcccatca agattatccg ttcgaagcac tggtcgaaaa gctggacatc   6000

cagcgggatc tcagccgcaa tccgctgttt gacaccatgt ttattttgca aaacctggac   6060

caaaaagctt acgagctgga tgggctgaaa ctggaggcat atccggcaca agcaggcaac   6120

gccaaattcg atctcacgct ggaagcgcac gaggacgaga caggcattca ttttgcgctc   6180

gtctactcga ccaaattgtt ccagcgagaa tcaatcgaaa gaatggcggg tcacttcctg   6240

caagtgctgc gccaagtcgt tgccgaccaa gcaactgcct tgcgcgagat cagcctgctc   6300

agcgaggaag agcgccgaat tgtgaccgtt gatttcaaca acacgtttgc ctatccgcgc   6360

gatctgacga ttcaggagct gttcgagcag caggcagcaa aaactccgga gcatgcagcg   6420

gtcgtgatgg acggacagat gctgacgtat cgggagctga acgaaaaagc gaaccagctc   6480

gcccatgtcc ttcgtcaaaa cggagtcggg aaagagagca tcgtcggtct gctcgcagat   6540

cgttcgctgg aaatgattac aggcatcatg gggattctca aagcgggcgg cgcctacctg   6600

ggactggacc cggagcatcc gtccgaacgc ctggcttaca tgttggaaga tggcggcgtg   6660

aaagttgtcc tcgtgcaaaa gcacttgctg ccgctcgtcg gcgaagggct gatgccaatc   6720

gttttggaag aggagagcct gcgcccggaa gattgcggca atccggcgat tgtcaacggt   6780

gcgagtgacc tggcttatgt gatgtacacc tcaggctcta caggcaagcc aaaaggagtc   6840

atggtcgagc atcgcaacgt cacccgcttg gtcatgcata cgaattacgt gcaagtgcgc   6900

gagagcgacc ggatgattca aaccggcgcg attggcttcg acgccatgac atttgagatt   6960

tttggagcct tgctgcacgg ggccagcctg tatttggtga gcaaggacgt cttgctggat   7020

gccgaaaagc tgggcgactt cctgcggacg aatcagatta cgaccatgtg gctgacctcg   7080

ccgctcttca accagctttc gcaagacaat ccggcgatgt ttgacagctt gcgcgccttg   7140

atcgtcggtg gcgaagcgtt gtcgccgaag cacatcaacc gggtaaaaag tgcccttcct   7200

gacctggaaa tctggaacgg atacggcccg accgaaaaca cgaccttctc gacgtgctat   7260

ttgattgagc agcattttga agagcagatt ccgatcggca agccgattgc aaactccacc   7320

gcgtatatcg tcgacggcaa caatcagccg cagccgatcg gcgtaccggg tgaactgtgc   7380

gtcggtggtg acggtgtcgc aagaggctat gtgaacaagc cggaattaac cgccgaaaag   7440

tttgtgccca atccgtttgc gcctggcgaa acgatgtatc gcaccggaga tttggcgaga   7500

tggctgccgg atgggacgat tgagtatttg ggccgaatcg accagcaggt caaaatcagg   7560

ggataccgga tcgagcttgg ggaaatcgag acggtcttgt cccagcaggc acaagtaaaa   7620

gaagcagtcg tggccgtgat cgaggaggcg aacgggcaaa aagctctctg cgcttacttt   7680

gtgccagaac aggccgtcga cgccgcagag ctgcgagaag cgatgtccaa acaattgcct   7740

ggctacatgg tccctgctta ctatgtgcaa atggaaaagc tgccgttgac cgcgaacgga   7800

aaggtcgacc gccgggcatt gccgcagcca tccggcgagc ggacgacagg aagcgccttt   7860

gtcgctgcgc aaaatgatac cgaagcgaag ctgcaacaga tttggcaaga agttttgggc   7920

attccggcaa tcggcattca cgacaacttc tttgaaatcg gcggtcattc cttgaaggcg   7980

atgaacgtca tcacgcaagt ccataaaaca ttccaggtgg agctgccgtt aaaagcgctg   8040

tttgccactc cgacgatcca tgagttggct gcgcatattt cggaaaaaac cgagtacacc   8100

gcgattcaac ccgtggcagc gcaggagttt tacccggttt catctgcgca aaaaagaatg   8160

tatatcctgc aacagttcga aggcaacgga atcagctaca acatttcggg tgcgattctc   8220

ctggaaggaa agctggacta cgcccggttt gccagcgctg tgcaacagct ggcagagcgc   8280

cacgaagctt tgcgcacctc gttccaccgg atcgacggcg agcctgtgca aaaagtgcac   8340

gaggaagtag aagtgccgct tttcatgctg gaggctcccg aagaccaggc ggagaaaatc   8400

atgcgcgagt ttgtccgtcc gtttgatctc ggggtcgctc cgctgatgcg aacaggtttg   8460

ctcaagctgg gcaaagaccg ccatttgttt ttgctcgaca tgcaccatat catctcggac   8520

ggcgtttctt cgcaaatttt gctgcgtgaa tttgccgagt tgtaccaggg agcagacttg   8580

cagccgcttt cgctgcaata caaagatttc gctgcttggc aaaatgagct gtttcagacg   8640

gaggcataca agaagcagga gcagcactgg ctgaacacgt ttgctgatga aattccgctc   8700

ttgaacctgc cgactgacta tccgcgccct agcgtgcaaa gctttgcagg cgatctcgtc   8760

ctttttgccg ccggaaaaga actgctggag cggttgcaac aggtagcgtc agaaacaggc   8820

accaccttgt acatgatttt gcttgccgcc tacaatgtgc tgctgtccaa gtataccggc   8880

caggaagaca tcatcgtcgg gacgcctgtc gctggacgtt cccatgcgga cgtggaaaac   8940

atcatgggca tattcgtgaa cacattggcg ctgcgcaacc agcctgccag cagcaaaacg   9000

atgttagaaa ataatattac acaatgtgac tcaatcaatg atgtttatct taaagaagaa   9060

gcaataacat tgatggatat gcttgagagt caacttaagc accaggcaga tggatatgtt   9120

gttattgatc aagaagaatc tctcagttac gctgatttct atttgagggt gaaagagata   9180

gggtattgtc tgtcagaaat tagctcaaag aattcggtgg gtattgggct tttttgtgat   9240

ccttctatag atttaatttg tggtgcatgg ggtattttgt cagcggataa agcttatttg   9300

ccgttatcgc ctgactatcc aactgaacgc ctcaaatata tgatagaaga ttctggtatt   9360

gatgtgattt ttacgcaatc gcacttaaaa gcacagctac aggacattgc accaaaatca   9420

gtattaatta tgacaccaga agatgtcgct ctgacgataa aaacacgaac aatagaagat   9480

attctgggca cagttcaagt tcctaaaccc actagtctgg cttatattat ttatacctct   9540

ggtagcacgg gtaagccaaa gggagtgatg attgaacatc acagtattgt aaatcaaatg   9600

agatttcttg caaaagcgtt caaattagga tgtcattccc ggattttaca gaaaacacca   9660

atgagttttg atgcggctca atgggaaatt ctagcgcctg caattggtgg tcaagtgatt   9720

atgggtcctt taggttgcta tcgcgatccg gatgcaatta ttaaaaccat tcttcagcat   9780

caagtaacga ctttgcaatg tgttcctact ttgctacaag cgttactgga taatcctaat   9840

tttttggatt gcttatcatt gactcaagta ttcagtgggg gagaagcgct gacaaccaaa   9900

ttagccacgc aatttttgaa tagttttact cactgtgaat taatcaattt atatggcccg   9960

acagaatgta cgattaattc atcatttttc cgggtgacaa atgagacttt gccgaattat  10020

caaacctcta tttcgattgg tgcacctgta gataataccg aatactacgt tcttgatgat  10080

gatagattac ctgtggcggt tggcgaaatt ggcgagcttt atatttcggg tgctcaatta  10140

gcacgtggtt atttgcataa accagaaatg acaaaagata aatttatttg taatcacctt  10200

gtatcaggaa ctcaacatca atggttatat cgaacgggag atctggtaac cagaggggct  10260

gatggtaata cttattttgt tggtcgggtt gatagccagg tcaaattacg aggttaccgt  10320

attgagcttg atgaaatacg ccatgcgatt gaagaacata gctggataaa gacggcggca  10380

atgttaatta agaaggatgc cagaacgggt ttccaaaatc tcatcgcgtg tgtggaatta  10440

gatgagaaag aagctgcatt gatggatcaa ggtaatagta gctcacatca caaatcaaaa  10500

gccgataaac tacaggtgaa agcccaactt tctaattctg gttgtcgaag tgaagagtta  10560

tgtgaaaatc gccctacatt cttacttcct tatcaagaag gggagataaa acagagagaa  10620

tatgcatttg gacgcaagac atatcgctat tttgagggaa cagaaataac ggtagagaaa  10680

ttaaaaaaat tgctgacagc cactcaatcg aatgaaatta gctctttgcc actgagtcat  10740

ctaaccctga atgatttcgg ttatgcattg cgttattttg gtcagtttac cagccatcaa  10800

cgtttattgc ccaaatatgc ctatgcttca ccgggtgctc tctatgcgac acaaatgtat  10860

tttgaattgc ataatgttct cggtttggat gcggggattt actattatca tccagtgaca  10920

cataagttaa taaaaatttc aacattgagt cgtcggcaaa tgccaacgat aaaagtgcat  10980

tttattggca agcatgaagc cattgagccc gtttataaga acaatataca agaagttctg  11040

gaaatggaag cgggccatat gatgggtctt tttgatgacg tattaccgga aattggcttg  11100

agtattggta aaagtgaata tcaagatgaa tgtccagatt ggtatgatgg tgatattcag  11160

gattattatc ttggtgcatt tgaaatatgt agctatgaac atggattgcc gccatttgag  11220

actgatattt atttacaaac acatgcccat aaaatacctg agatgccgtg tggtttatat  11280

cacttttcta acggggaatt tgtacgaata agtgatgata ttgtccgaaa aaaggatgtt  11340

attgcgatta atcagcaagt ttatgatcgc tccagttttg gcgtgtcaat tattccacgc  11400

tgtgtccctg aatggcatta ttatataaca ctgggtcgtc ggttacatgc gttacaaagt  11460

aatccattgt atattggatt aatgtcatct ggttacagtt cgaagagcaa taacgattta  11520

ccttcggcga aaaggatgcg atctattctc aatgcacttg atagacctat ggcggcattt  11580

tatttctgca taggtggggg tattagccaa gcgcaatata tgtgtgaagg catgaaagaa  11640

gatgttgttc atatgaaagg gccagttgaa atcattaaag atgatcttca acaacaactc  11700

cctcaatata tgattccaaa taaggtatta gttttcgata aattaccttt gacggccaat  11760

ggaaaagtgg attatcaatc tttatcagaa tctaaagccg tggagaatgt ttcaacacag  11820

cgtctattgg tgccattaca tacagatact gaaataaggc ttggaaaaat ttggatggaa  11880

gtactgaaat gggattcagt atctgccctc gatgattttt tcgaaagtgg gggtaattct  11940

ttgatggccg ttgcaatggt taataagatc aatgcggcct ttaatattcg ttttccgtta  12000

cagatacttt ttcaatctcc taatatagca gaattggcta agtggattga acagacagac  12060

tctaaaacaa tatcaagatt aattttattg aatcaggcaa gcaaagaccc catttactgt  12120

tggccgggtt tgggcggata tcctatgagt ttgagattgc ttgctaataa agtcgttcct  12180

gatcgggcat tttatggaat acaggcatat gggataaacg agagtgaaat accgttttct  12240

tctatccaga gaatggcaga agaggatatt aaagagataa agaaaataca gccagaaggg  12300

ccatatatat tgtggggata ttcatttggt gcccgagtag catttgaagt tgcataccag  12360

cttgaacaag cgggagaaga agttaacgca ttgaatttat tggctccggg atctcctcat  12420

cttgatatga agcaagcgga atatatggat aaaggcgctg aatttactaa tccggctttt  12480

gttaaaatac ttttttctgt attttctcgt tcaatcaaca gcccaatggt taaaacttgc  12540

ttagaacaag taaatagtga aacgacattt attaacttta tatgtagtcg ttttaaaaac  12600

ttggaaccat cattagtaaa acgtatcgtt aggattgtga ctttgactta tgatttcaag  12660

tacagtattg atgagcttta tcacagacac ctaaaggcac ctataactat tttcaaggcg  12720

aatagagata atgattcatt tatcgaggaa tcggatgtga tttcatcaat gtcgcctaaa  12780

ataattgaat taatatcgga tcactatcaa ctgttggaaa gtgaaggtgt tgctgagatt  12840

gagaaaataa tctaa                                                   12855


<210>  20
<211>  3267
<212>  DNA
<213>  Brevibacillus parabrevis

<400>  20
atgttagcaa atcaggccaa tctcatcgac aacaagcggg aactggagca gcatgcgcta     60

gttccatatg cacagggcaa gtcgatccat caattgttcg aggaacaagc agaggctttt    120

ccagaccgcg ttgccatcgt ttttgaaaac aggcggcttt cgtatcagga gttgaacagg    180

aaagccaatc aactggcaag agccttgctc gaaaaagggg tgcaaacaga cagcatcgtc    240

ggtgtgatga tggagaagtc catcgaaaat gtcatcgcga ttctggccgt tcttaaagca    300

ggcggagcct atgtgcccat cgacatcgaa tatccccgcg atcgcatcca atatattttg    360

caggatagtc aaacgaaaat cgtgcttacc caaaaaagcg tcagccagct cgtgcatgac    420

gtcgggtaca gcggagaggt agttgtactc gacgaagaac agttggacgc tcgcgagact    480

gccaatctgc accagcccag caagcctacg gatcttgcct atgtcattta cacctcaggc    540

acgacaggca agccaaaagg caccatgctt gaacataaag gcatcgccaa tttgcaatcc    600

tttttccaaa attcgtttgg cgtcaccgag caagacagga tcgggctttt tgccagcatg    660

tcgttcgacg catccgtttg ggaaatgttc atggctttgc tgtctggcgc cagcctgtac    720

atcctttcca aacagacgat ccatgatttc gctgcatttg aacactattt gagtgaaaat    780

gaattgacca tcatcacact gccgccgact tatttgactc acctcacccc agagcgcatc    840

acctcgctac gcatcatgat tacggcagga tcagcttcct ccgcaccctt ggtaaacaaa    900

tggaaagaca aactcaggta cataaatgca tacggcccga cggaaacgag catttgcgcg    960

acgatctggg aagccccgtc caatcagctc tccgtgcaat cggttccgat cggcaaaccg   1020

attcaaaata cacatattta tatcgtcaat gaagacttgc agctactgcc gactggcagc   1080

gaaggcgaat tgtgcatcgg cggagtcggc ttggcaagag gctattggaa tcggcccgac   1140

ttgaccgcag aaaaattcgt agacaatccg ttcgtaccag gcgaaaaaat gtaccgcaca   1200

ggtgacttgg ccaaatggct gacggatgga acgatcgagt ttctcggcag aatcgaccat   1260

caggtgaaaa tcagaggtca tcgcatcgag cttggcgaaa tcgagtctgt tttgttggca   1320

catgaacaca tcacagaggc cgtggtcatt gccagagagg atcaacacgc gggacagtat   1380

ttgtgcgcct attatatttc gcaacaagaa gcaactcctg cgcagctcag agactacgcc   1440

gcccagaagc ttccggctta catgctgcca tcttatttcg tcaagctgga caaaatgccg   1500

cttacgccaa atgacaagat cgaccgcaaa gcgttgcccg agcctgatct tacggcaaac   1560

caaagccagg ctgcctacca tcctccgaga accgagacag aatcgattct cgtctccatc   1620

tggcaaaacg ttttgggaat tgaaaagatc gggattcgcg ataattttta ctcgctcggc   1680

ggagattcga tccaagcgat ccaggtcgtg gctcgtctgc attcctatca attgaagcta   1740

gagacgaaag acttgctgaa ttacccgacg atcgagcagg ttgctctttt tgtcaagagc   1800

acgacgagaa aaagcgatca gggcatcatc gctggaaacg taccgcttac acccattcag   1860

aagtggtttt tcgggaaaaa ctttacgaat acaggccatt ggaaccaatc gtctgtgctc   1920

tatcgcccgg aaggctttga tcctaaagtc atccaaagtg tcatggacaa aatcatcgaa   1980

caccacgacg cgctccgcat ggtctatcag cacgaaaacg gaaatgtcgt tcagcacaac   2040

cgcggcttgg gtggacaatt atacgatttc ttctcttata atctgaccgc gcaaccagac   2100

gtccagcagg cgatcgaagc agagacgcaa cgtctgcaca gcagcatgaa tttgcaggaa   2160

ggacctctgg tgaaggttgc cttatttcag acgttacatg gcgatcattt gtttctcgca   2220

attcatcatt tggtcgtgga tggcatttcc tggcgcattt tgtttgaaga tttggcaacc   2280

ggatacgcgc aggcacttgc agggcaagcg atcagtctgc ccgaaaaaac ggattctttt   2340

caaagctggt cacaatggtt gcaagaatat gcgaacgagg cggatttgct gagcgagatt   2400

ccgtactggg agagtctcga atcgcaagca aaaaatgtgt ccctgccgaa agactatgaa   2460

gtgaccgact gcaaacaaaa gagcgtgcga aacatgcgga tacggctgca cccggaagag   2520

accgagcagt tgttgaagca cgccaatcag gcctatcaaa cggaaatcaa cgatctgttg   2580

ttggcggcgc tcggcttggc ttttgcggag tggagcaagc ttgcgcaaat cgtcattcat   2640

ttggaggggc acgggcgcga ggacatcatc gaacaggcaa acgtggccag aacggtcgga   2700

tggtttacgt cgcaatatcc ggtattgctc gacttgaagc aaaccgctcc cttgtccgac   2760

tatatcaagc tcaccaaaga gaatatgcgg aagattcctc gtaaagggat cggttacgac   2820

atcttgaagc atgtgacact tccagaaaat cgcggttcct tatccttccg cgtgcagccg   2880

gaagtgacgt tcaactactt gggacagttt gatgcggaca tgagaacgga actgtttacc   2940

cgctcaccct acagcggcgg caacacgtta ggcgcagatg gcaaaaacaa tctgagtcct   3000

gagtcagagg tgtacaccgc tttgaatata accggattga ttgaaggcgg agagctcgtc   3060

ctcacattct cttacagctc ggagcagtat cgggaagagt ccatccagca attgagccaa   3120

agttatcaaa agcatctgct tgccatcatc gcgcattgca ccgagaaaaa agaagtagag   3180

cgaacgccca gcgatttcag cgtcaaaggt ctccaaatgg aagaaatgga cgatatcttc   3240

gaattgcttg caaatacact gcgctaa                                       3267


<210>  21
<211>  10764
<212>  DNA
<213>  Brevibacillus parabrevis

<400>  21
atgagtgtat ttagcaaaga acaagttcag gatatgtatg cgttgacccc gatgcaagag     60

gggatgctgt ttcacgcctt gctcgatcaa gagcacaact cgcatctggt acagatgtcg    120

atttcgttgc agggcgatct tgacgttggg ctatttacgg atagcctgca tgtgctggta    180

gagagatacg atgtattccg cacgttgttt ctctatgaaa agctgaagca gcctttgcaa    240

gttgtcttga agcaacggcc tattccgatc gaattttacg acttgtctgc ctgcgacgag    300

tccgagaaac aacttcgcta tacgcaatac aaaagggcgg atcaggagcg gacgtttcat    360

ctggcaaaag acccgttgat gcgggtcgcc cttttccaaa tgtcccagca cgactaccag    420

gtcatctgga gctttcatca catcctcatg gacggctggt gcttcagcat tatttttgat    480

gacttgcttg ccatctactt gtccttgcaa aacaagacgg cactctccct ggagcccgta    540

cagccataca gtcgctttat caactggctg gaaaaacaaa ataaacaggc cgctctcaac    600

tattggagcg actatctgga agcctatgaa caaaagacta ccttgccgaa gaaggaagct    660

gccttcgcca aagcatttca accaacccaa taccgctttt cgctgaaccg caccttgacc    720

aagcagctcg ggaccatcgc cagtcaaaat caagtgacgc tatcgacggt gattcaaacg    780

atctggggag ttctcctgca aaaatacaat gcggcccatg atgtgctgtt cggctctgtt    840

gtatccggac gccctacaga catcgtcgga atcgacaaaa tggttggctt gtttatcaat    900

acgattccat tccgggtgca agcgaaagct ggtcaaacgt tttccgagct gttgcaagct    960

gtgcacaaaa gaactttgca atcacagccg tatgagcacg tgcctttgta cgacattcaa   1020

actcagtccg tcttgaagca ggagctgatt gaccacctgc tggtcatcga aaattacccg   1080

ctggtagagg ctttgcagaa aaaagcattg aaccagcaga tcggcttcac gattactgct   1140

gtggaaatgt tcgagccgac caattacgac ttgactgtca tggtgatgcc aaaagaagag   1200

cttgccttcc gttttgacta caatgcggct ctgtttgacg aacaggtcgt gcaaaaactg   1260

gcggggcacc tccaacagat cgcggattgc gtggcaaaca attcgggagt cgagctttgc   1320

cagattccgt tgctgacaga agcagaaact agccagctgt tggcaaagcg tacggaaaca   1380

gcggctgact atcctgccgc aaccatgcac gagctgtttt cgcggcaggc agaaaaaacg   1440

cctgagcaag tggcggtagt cttcgcggat cagcacctga cgtatcggga gctggatgaa   1500

aaatccaatc agctcgcccg ctttttgcgc aaaaaaggca ttggcacggg cagtcttgtc   1560

ggcacgctgc tggatcgctc gctggacatg atcgtcggaa tcctcggcgt cttgaaggca   1620

ggcggcgcat ttgtgccgat cgacccggag ttgcctgccg aacgaatcgc ttacatgctg   1680

acgcatagca gagttccatt ggtcgtgacg caaaatcatt tgcgggcaaa agtgaccacg   1740

cctacagaaa caattgacat caacacagcg gtgatcgggg aagagagccg cgcccctatc   1800

gaatcgctca atcagccgca tgacttgttt tacatcatct atacgtccgg aacgacaggg   1860

caaccgaaag gcgtcatgct ggagcatcgc aacatggcga acctgatgca ttttacgttt   1920

gatcagacga acatcgcttt tcatgaaaaa gtgttgcagt ataccacgtg cagctttgat   1980

gtttgctacc aggaaatttt ctccacgctg ctatccgggg gccagctcta cctgatcacg   2040

aacgagctga gacggcatgt ggaaaagctg tttgctttca tccaggaaaa gcagatcagc   2100

attttgtctc tcccggtgtc cttcctgaaa tttattttta acgaacaaga ctacgcgcaa   2160

agcttcccgc gttgtgtcaa acatatcatc acggccgggg aacaactcgt cgtcacacac   2220

gagctgcaaa agtatctgcg ccagcatcgc gtatttttgc acaatcacta cggcccgtcg   2280

gagacgcatg tggtgacgac atgcacgatg gacccgggac aggcgatacc agagctgccg   2340

cccatcggaa agccgatcag caacacaggc atttacattt tggatgaagg gctgcaattg   2400

aagccggagg ggatcgtcgg ggagttgtac atttccggcg caaacgtagg aagagggtat   2460

ttgcaccagc cggagctgac cgcggagaag tttctcgaca atccgtatca gccaggcgaa   2520

agaatgtacc gaacgggtga tctggccctt tggttgccgg atggccagct cgaatttttg   2580

ggccgaatcg accatcaggt aaaaatcagg ggccatcgca tcgagctggg agagatcgaa   2640

tcgcgcctgc tcaaccatcc cgccatcaag gaagcggtgg ttatcgaccg agcagacgag   2700

acaggcggca agtttttgtg cgcctatgtc gtcctgcaaa aagcgctcag cgacgaagag   2760

atgcgggcat acttggcgca agcgttgccg gagtatatga tcccttcctt tttcgtgacg   2820

ctggagcgga ttccagtcac gccgaacgga aaaacagaca ggcgagcttt gccgaagccg   2880

gaaggaagtg ccaagacgaa agcggattac gtcgccccga cgactgagct ggaacaaaag   2940

ctggtcgcga tttgggagca aattcttggc gtgtcgccga tcggcattca ggatcatttt   3000

ttcacgctgg gcggccattc gttaaaagcg attcagctca tttcccgcat ccaaaaggaa   3060

tgccaggcgg atgtcccgct gcgcgtcctg tttgagcaac cgacgattca agcgctggca   3120

gcgtatgtgg aaggcgggga ggaaagcgcg tatctcgcca ttccccaggc cgagccgcaa   3180

gcgtattatc ccgtatcgtc tgcgcaaaaa cgcatgctca tcttaaacca gctcgatccg   3240

cacagcacgg tttacaacct gcctgtcgcg atgatcctcg aaggaacgct ggataaagct   3300

cggctggagc acgccatttc caacctggtg gctcgccatg agtcgttgcg cacgtcgttt   3360

catacgatca acggggagcc agtttcccgc atccatgagc aaggccactt gccgattgtt   3420

tacttggaaa cggcggaaga gcaagtgaac gaggtcattt tggggttcat gcagccgttt   3480

gatctggtaa cagctccgct atgccgggtt ggcttggtga agctcgcaga gaaccgtcac   3540

gtcctgatca tcgacatgca ccatatcatt tcggacggag tctcttctca gctcatcctg   3600

aatgactttt cccgtttgta tcaaaacaaa gctttgccag agcagcgcat tcactataaa   3660

gacttcgccg tttgggaaaa agcgtggaca caaacgaccg attaccaaaa acaggaaaaa   3720

tattggctcg atcgatttgc gggcgaaatc ccggttttga acctgccgat ggattacccg   3780

cggccagctg ttcaaagctt tgagggcgaa cgttatttgt tccgcacaga aaaacagttg   3840

ttggaaagtt tgcaggacgt agcccaaaag acaggcacga ccttgtacat ggtgcttctc   3900

gcagcctatc atgtgctgct ttccaaatac tccgggcagg atgacgtgat gatcggcacc   3960

gtgactgccg gcagggtgca cccggatacg gagagcatga cggggatgtt cgtcaacacg   4020

ctggcgatgc gcaatcagtc tgcgccgacc aaaacgttcc ggcaattttt gctggaggta   4080

aaagacaaca cgctggccgc ttttgaacac gggcaatatc cgtttgaaga gcttgtcgaa   4140

aagttggcga tccagcgaaa ccggagccga aacccgctgt tcgacacctt gttcattttg   4200

caaaacatgg atgccgacct gatcgagctg gatggactga ccgtgacgcc ttatgtgcca   4260

gagggggaag tcgccaagtt cgatctgtcg ctggaagcaa gcgaaaacca ggcgggactt   4320

tccttctgct tcgaattttg caccaagctg ttcgcacgcg agacgatcga gcgcatgtcg   4380

cttcattact tgcaaatttt gcaggcagtc agcgcaaaca cggagcagga gctggcgcaa   4440

atcgagatgc tgactgcgca tgagaagcag gagctgctcg ttcacttcaa cgacacggcc   4500

gccctgtatc cagcggagag cacgctgtcg cagctgtttg aagatcaggc acagaaaact   4560

cctgagcaaa ccgccgtcgt cttcggtgac aaacgactga cgtaccgcga actgaacgag   4620

cgggccaacc agctcgcgca cactttgcgg gcaaaaggcg tgcaggctga gcaaagcgta   4680

gggatcatgg cgcaaagatc gttggaaatg gcgatcggaa ttatcgctat tctcaaagcg   4740

ggcggggcgt atgtgccgat cgatccggat tatccgaatg agcggattgc ttacatgctg   4800

gaagattgcc gccgtctggt gctgacccag cagcagctcg ccgaaaagat gaccgcaaac   4860

gtggaatgcc tgtatctgga tgaggagggc agctactcgc ctcagacgga aaacatcgag   4920

ccgatccata ccgctgctga tctcgcttac atcatctaca catccggtac gacaggcagg   4980

ccaaaaggcg tcatggtaga gcatcgggga atcgtcaaca gtgtgacgtg gaacagggac   5040

gagtttgccc tttctgtccg ggacagtgga acgctgtcgc tatcttttgc cttcgatgcc   5100

tttgccctta ctttctttac gttgattgta tcaggctcca cggtcgtcct gatgccggat   5160

cacgaagcca aagatccgat cgcgctacgc aacctgattg ccgcttggga atgcagctac   5220

gtcgttttcg tgcccagtat gttccaggcg atattggagt gcagcactcc ggcagacatc   5280

cgctccatcc aggcagtcat gctcgggggc gaaaagctgt cgccgaagct tgttcagctg   5340

tgcaaagcga tgcatccgca gatgagcgtg atgaatgcat acggcccgac ggagagcagc   5400

gtcatggcca cctacctgcg agatacacag ccagatcagc cgatcaccat cgggcggccg   5460

attgccaaca ccgccattta catcgtagac cagcaccatc aactgctgcc tgtcggggtg   5520

gtaggggaaa tctgcatcgg cggtcacggc ttggcgcggg gctattggaa aaagccggag   5580

cttactgcgg agaaattcgt ggccaatcca gctgttccgg gagagcgcat gtacaaaaca   5640

ggcgatctgg gcagatggct ccacgacggc acgattgatt ttataggccg cgtcgatgac   5700

caaatcaagg tgagaggata ccggattgag gtcggggaga ttgaagcggt tttgctcgct   5760

tacgatcaga cgaatgaagc tatcgtcgtc gcttatcagg acgatcgcgg cgattcctat   5820

ctggctgcgt atgtcacggg aaaaacggcg atagaggaat ccgagcttcg cgcgcatctg   5880

ttgcgagagc ttccggccta catggtgccg acctacctga ttcaactgga cgctttcccg   5940

ctcacgccaa acggcaaggt cgaccgcaag gcactgccca agccggaagg aaagcctgca   6000

acaggagcag cttatgtcgc acccgctaca gaagtggagg cgaagctggt cgccatttgg   6060

gagaatgcgc tggggatttc cggcgtcggg gtgttggatc acttttttga gctgggcggt   6120

cattccttga aagcgatgac ggttgtggcg caagtgcatc gcgagtttca aatcgacctt   6180

ttgctgaagc agttttttgc agcgccaacc atccgggact tggcccgctt gatcgaacat   6240

agcgaacagg cagccggcgc cgccattcaa ccggcagagc cgcaagcgta ttatccggta   6300

tcttctgctc agcagcggat gtacttgctc catcagcttg aaggtgccgg aatcagctac   6360

aacacaccgg gcatcatcat gctggaaggc aagctcgatc gcgagcaatt ggcgaatgcg   6420

ctgcaagcgt tggtagatcg tcacgatatt ttgcggacgt cttttgagat ggtcggagac   6480

gagctggtgc aaaaaattca tgaccgcgtg gccgtgaaca tggagtatgt gacggcagaa   6540

gagcagcaga tcgatgacct tttccacgcg ttcgtccgtc cgtttgatct ttctgtgccg   6600

ccattgctcc gcatgagcct ggtgaaactc gcggatgagc gtcacctgct cctgtacgac   6660

atgcaccata ttgctgccga tgccgcatcg atcacgatcc tgttcgatga actggctgaa   6720

ttgtaccagg gaagagaact gccggaaatg cgcatccagt acaaagattt tgctgtctgg   6780

caaaaagcct tgcatgagtc ggatgccttc aagcagcagg aagcgtattg gctgagcacg   6840

ttcgctggaa atatcaccgc tgtcgatgtg ccgacagatt ttccgcgccc agccgtgaaa   6900

agttttgcag gggggcaagt caccctgtcc atggaccaag agctgctcag tgctttgcac   6960

gagttggctg cgcatacgaa tacgacgctg tttatggttt tgctggccgc ctacaacgtg   7020

ctgctcgcaa aatacgctgg gcaagacgac atcatcgtgg gaacgccgat ctccggcagg   7080

tcacgcgccg agcttgcgcc tgtcgtcggc atgttcgtcc atacgctggc gatccgcaac   7140

aaaccgaccg ccgagaagac attcaagcag tttttgcagg aggtcaagca aaacgcgctc   7200

gatgctttcg accaccagga ctacccgttt gaaagccttg tggaaaagct gggcattccg   7260

cgcgatccgg ggcgcaatcc gctgtttgac accatgttca tcctgcaaaa cgatgagttg   7320

cacgcaaaaa cgctggatca gctcgtctat cgcccttatg aatcggacag cgcgcttgac   7380

gtggcgaaat tcgacttgtc gttccatctg accgagcggg aaaccgacct gttcttgcgc   7440

ctggaatact gcaccaagct gttcaagcaa caaacggtag aacgaatggc gcaccacttc   7500

ttgcaaattt tgcgagcggt cacggccaat ccggaaaatg aattgcaaga gatcgagatg   7560

ctgacagcag cagaaaagca aatgctgctg gtggcgttca acgatacgca cagagaatac   7620

cgggcagatc aaacaatcca gcaacttttt gaagagctgg cggaaaaaat gcctgagcac   7680

acggcgctcg tattcgaaga aaagcgcatg tcgttccggg agctgaatga aagagcgaac   7740

cagctcgcag ccgttttgcg ggaaaaagga gtcgggccag cgcagatcgt cgctttgctg   7800

gtagagcgtt ccgccgagat ggtcattgcc acgcttgcca cgttaaaagc gggcggcgcc   7860

tttttgcccg tcgatcctga ttatccggaa gagcgaatcc gctacatgct ggaggacagc   7920

caggcaaaac tggtggtgac ccatgcgcac ttgctgcaca aagtgagcag tcagtccgaa   7980

gtcgttgatg tggatgaccc tggaagctac gcaacacaga cagacaacct gccgtgcgca   8040

aacacaccgt ctgatttggc ttatatcatt tacacgtccg gtacgacggg caagccaaaa   8100

ggcgtcatgc tggagcacaa aggggtagcg aatctgcaag cggtatttgc ccatcatcta   8160

ggcgtcacgc cgcaagatcg ggcagggcat tttgccagca tctcgtttga cgcatcggtg   8220

tgggatatgt ttggcccgtt gctgtcggga gcgaccttgt acgtcttgtc ccgagacgtc   8280

atcaacgatt ttcaacgatt cgccgaatac gttcgcgata acgcgatcac cttcctcact   8340

ttgccgccga cgtacgcgat ttatctggag ccggagcagg tgccgtcgtt acgcaccctg   8400

attacagccg gatcggcttc ctccgttgca ttggtggata aatggaaaga aaaagtcacc   8460

tatgtcaatg gatacggccc aacagagagc accgtttgcg cgacactgtg gaaagccaaa   8520

ccggatgagc cagtcgaaac gatcacgatt ggcaaaccga ttcagaacac caagctgtac   8580

atcgtggatg accagttgca gttgaaagcg ccggggcaga tgggagaact gtgcatcagc   8640

ggcttgtcgc tggcgagagg ctattggaat cgtccagagc tgaccgccga gaagttcgtc   8700

gacaacccgt ttgtgccagg aacaaagatg taccggacag gcgacctggc aagatggctg   8760

ccagatggaa ctatcgagta tctgggcaga atcgatcacc aagtgaaaat tcgcggacat   8820

cgtgtggaac tcggcgaagt ggaaagcgtg ctgctgcggt atgacacggt caaagaggca   8880

gctgccatca cacatgagga cgaccgcggc caagcttact tgtgcgccta ctacgtagcg   8940

gagggagaag ccacgcctgc gcaacttcga gcctatatgg aaaacgagtt gccgaactac   9000

atggttcccg ccttctttat ccagttggaa aagatgccgc tgacaccgaa tgacaagatt   9060

gaccgaaaag cgctgccgaa gccgaaccag gaggagaacc ggactgagca atatgcagcg   9120

ccgcaaaccg agctggaaca gttgctggct ggcatctggg cagatgtact ggggatcaag   9180

caagtcggga cgcaagacaa cttctttgaa ttgggcggcg attcgattaa agcgatccag   9240

gtatccaccc gcctgaatgc gtcaggctgg acgcttgcga tgaaagaact gttccagtac   9300

ccgacgattg aagaagctgc tctgcgcgtc atcccgaaca gccgagagag cgagcagggt   9360

gtcgtagaag gcgagattgc cttgacaccg atccagaaat ggttcttcgc gaacaacttc   9420

acggatcgtc accattggaa tcaggctgtc atgctgtttc gcgaggacgg ctttgacgag   9480

ggactcgtgc ggcaagcgtt ccagcaaatc gtcgagcatc acgatgcgct gcgcatggtc   9540

tacaagcaag aggacggggc gatcaagcaa atcaaccgcg ggctgaccga cgagcgcttc   9600

cgtttctact cttatgactt gaaaaatcac gcgaacagcg aagctcgcat cctggagctg   9660

tctgatcaga tccagagcag catcgatttg gagcacggcc cactcgttca cgtggctctg   9720

ttcgccacaa aagacgggga tcatttgctg gtcgcgatcc accatcttgt cgtggatggc   9780

gtctcctggc gcattttgtt cgaagatttt tcctcagcct actcgcaggc tctccatcag   9840

caggagatcg tcttgccgaa aaagacggac tccttcaaag actgggcggc tcaattgcaa   9900

aagtacgcgg acagcgacga gctgttgcgg gaagtggcat attggcacaa cttggagact   9960

acaacgacga ctgcggcact gccaacagat tttgtcacgg cagatcgcaa gcaaaaacat  10020

acgcggacac tgtcgttcgc gttgacagtc ccgcagacag aaaacctttt gcgtcacgtt  10080

catcatgcct atcacacaga gatgaacgac ctgctgctga cagcgctcgg cttggccgta  10140

aaagactggg cacatacgaa tggcgtcgtc atcaatctgg aaggccatgg gcgcgaagac  10200

atccagaacg aaatgaacgt cacgcgcacg attggctggt tcacttcgca atatccggtg  10260

gtgctcgaca tggaaaaagc cgaggacttg ccgtaccaga tcaagcaaac caaagaaaac  10320

ttgcgacgga ttccgaaaaa agggatcggc tacgagattt tgcgcacgct gacgacaagc  10380

cagttgcagc cgccattagc ctttacgctg cggccggaaa tcagctttaa ctatctcggt  10440

caattcgagt cggacggaaa aacaggcggg tttacattct cgccgctcgg aacagggcag  10500

ttgttcagcc cggaatcgga gcgagtgttc ctgctggaca tttccgccat gatcgaggac  10560

ggcgagctgc ggatcagcgt ggggtacagc cgtctccaat atgaggaaaa aacgattgcc  10620

agcctggcag acagctaccg gaagcacttg ctaggcatca tcgagcattg catggcaaaa  10680

gaagaaggcg agtacacccc gagcgacctg ggggatgaag agctgtccat ggaggagctg  10740

gaaaacatcc tggaatggat ttga                                         10764


<210>  22
<211>  19461
<212>  DNA
<213>  Brevibacillus parabrevis

<400>  22
atgaaaaagc aggaaaacat cgcaaaaatt tacccgctaa ccccattgca agagggtatg     60

ttgtttcacg ctgtcacaga cacgggcagc agcgcctatt gcctccagat gtctgcaacg    120

atcgagggcg attttcacct gccgcttttt gaaaagagtc tgaacaagct cgtggaaaac    180

tacgaagtat tgcgcacggc ttttgtatac caaaacatgc agcgacctcg ccaagtcgtg    240

ttcaaggaaa gaaaagtgac cgttccttgc gaaaacatcg cgcatttgcc aagcgcagag    300

caggacgcgt acatacaagc gtacacgaag caacatcatg cattcgacct gacaaaagac    360

aacttgatga aagcagccat ttttcaaacg gccgagaaca agtaccgatt ggtttgggcc    420

ttccatcata ttatcgtgga cggttggaca ttgggcgtct tgctgcataa gctgctgacc    480

tattacgcag cgctgcgaaa aggcgagccg attccgcggg aagcgacgaa gccgtacagc    540

gaatatatca agtggctgga taagcaaaac aaggacgagg ccctcgctta ttggcaaaac    600

tacctggcag ggtatgacca tcaggctgct tttccgaaaa agaagcttgg aacggaagca    660

agccgctatg aacatgtcga ggcgatgttc acgatcgctc ccgagaagac gcagcagctg    720

atccagatcg cgaaccaaaa tcaggcgacg atgagcagcg tgtttcaagc tctttggggc    780

attttggcca gcacatacaa aaatgcggac gatgtcgttt tcggctcggt cgtatcaggc    840

cgcccgccgc aaatccaagg aattgagagc atggtcggct tgttcatcaa cacgattccg    900

acccgcgtcc agacgaacaa acaacagacg ttcagcgagc tgctgcaaac cgtgcaaaag    960

caagccctgg cgtctgccac ctacgatttc gcgccgctgt acgaaattca gagcacaaca   1020

gtgctgaaac aggaattgat cgatcatttg gtcacgtttg aaaattaccc cgatcattcg   1080

atgaagcatc tggaagaatc attagggttt caattcaccg tagaaagcgg agatgagcag   1140

acctcctatg atttgaacgt ggtcgtcgcc ctcgctccct cgaacgagct gtacgtgaag   1200

ctaagctaca atgccgcggt gtatgaatcg tcattcgtaa acagaatcga agggcatctc   1260

cgcaccgtca tcgaccaggt gatcggcaat ccgcatgtac acctgcacga gatcggcatc   1320

atcaccgaag aggaaaagca gcaactgctc gtcgcctaca acgacacggc tgctgaatat   1380

ccgcgggaca aaacgatttt cgagctgatc gcggaacaag cgagccggac accagcgaaa   1440

gcagcagttg tttgcggcga ggacaccctg acctatcagg agctgatgga gcgttctgcc   1500

cagcttgcca atgctttgcg cgaaaaagga atcgccagcg gcagcatcgt ctcgattatg   1560

gcggaacatt cactggagct gatcgtggcg atcatggctg tcttgcggtc aggtgctgcc   1620

tacttgccga ttgatcccga gtacccgcaa gatcgcatcc agtatttgct cgatgacagc   1680

cagaccacgc tgctgttaac ccagtcgcat ctgcaaccaa acatccggtt tgcaggcagc   1740

gtgctttatt tggacgatcg ttccttgtac gaaggcggca gcacatcctt cgcacccgag   1800

agcaagcctg atgatttggc gtacatgatc tacacttccg gttctaccgg caatccaaaa   1860

ggggcgatga ttactcatca aggcctggtc aattacatct ggtgggccaa caaggtgtac   1920

gtccaaggcg aagcggtgga ctttccgctg tactcatcta tttcgttcga tttgaccgtc   1980

acctcgatct tcacgccgct tctgtccggc aacacgattc atgtgtacag aggggcagac   2040

aaggtacagg tcattttgga catcatcaaa gataacaaag tcgggatcat caagctgacg   2100

ccgacacacc tgaagctgat tgaacacatc gacggcaagg ccagcagcat cagacggttc   2160

atcgtcggcg gcgagaactt gccgacaaag ctggcgaagc aaatatacga ccatttcgga   2220

gagaacgtgc aaattttcaa cgagtacgga ccgaccgaaa ccgttgtcgg ttgcatgatt   2280

tacttgtatg acccgcaaac aacgacccag gagtcggtgc caatcggtgt cccggcagac   2340

aacgtccagc tttatttgct cgatgcttcc atgcagccgg tgcccgtcgg ctcgcttggc   2400

gaaatgtaca tagccggaga cggcgtagcc aaagggtatt tcaacagacc ggagctgacg   2460

aaggaaaagt ttatcgacaa cccgttccgt ccgggaacca aaatgtatcg aacaggcgac   2520

ctggcaaaat ggctgcctga tggaaacatg gagtatgcag gcagaatgga ctatcaagtg   2580

aagattcgcg gccatcggat cgagatgggc gaaatcgaaa cgcgcctgac gcagcatgag   2640

gcggtcaagg aagcggtcgt gatcgtggaa aaggatgaga gcggccaaaa cgtgttgtac   2700

gcgtaccttg tttccgagcg ggaactgacg gtagctgagc tgagagaatt tttggggcgc   2760

acgctgcctt cctatatgat tccttccttc tttattcgct tggcggaaat tccgctgacc   2820

gcgaacggaa aagtagagcg aaaaaaattg ccgaagccag ctggcgcagt cgttacaggc   2880

accgcgtatg cagctccgca aaatgaaatc gaggcaaagc tggccgagat atggcagcaa   2940

gtgctgggca taagccaggt agggattcac gacgatttct ttgacttggg cggacactcg   3000

ttgaaggcga tgactgtcgt tttccaagtc tcgaaagcgc tggaagtgga attgcccgta   3060

aaggccttgt tcgaacatcc aaccgttgcg gagctggccc gcttcctttc gcggtcggaa   3120

aaaaccgagt acaccgcgat tcaacccgtg gcagcgcagg agttttaccc ggtttcatct   3180

gcgcaaaaaa gaatgtatat cctgcaacag ttcgaaggca acggaatcag ctacaacatt   3240

tcgggtgcga ttctcctgga aggaaagctg gactacgccc ggtttgccag cgctgtgcaa   3300

cagctggcag agcgccacga agctttgcgc acctcgttcc accggatcga cggcgagcct   3360

gtgcaaaaag tgcacgagga agtagaagtg ccgcttttca tgctggaggc tcccgaagac   3420

caggcggaga aaatcatgcg cgagtttgtc cgtccgtttg atctcggggt cgctccgctg   3480

atgcgaacag gtttgctcaa gctgggcaaa gaccgccatt tgtttttgct cgacatgcac   3540

catatcatct cggacggcgt ttcttcgcaa attttgctgc gtgaatttgc cgagttgtac   3600

cagggagcag acttgcagcc gctttcgctg caatacaaag atttcgctgc ttggcaaaat   3660

gagctgtttc agacggaggc atacaagaag caggagcagc actggctgaa cacgtttgct   3720

gatgaaattc cgctcttgaa cctgccgact gactatccgc gccctagcgt gcaaagcttt   3780

gcaggcgatc tcgtcctttt tgccgccgga aaagaactgc tggagcggtt gcaacaggta   3840

gcgtcagaaa caggcaccac cttgtacatg attttgcttg ccgcctacaa tgtgctgctg   3900

tccaagtata ccggccagga agacatcatc gtcgggacgc ctgtcgctgg acgttcccat   3960

gcggacgtgg aaaacatcat gggcatattc gtgaacacat tggcgctgcg caaccagcct   4020

gccagcagca aaacgtttgc gcaatttttg caggaagtca agcaaaacgc gcttgcagcc   4080

tatgaccatc aagattatcc atttgaagaa ctcgtggaaa aactggcgat tcagcgggat   4140

attagccgaa atccgttgtt tgacacgttg ttttctttgg aaaacgcgaa ccagcagtcg   4200

cttgccatcg ccgagctgac agcgtcgccc tatgagctgt tcaacaaaat ttccaagttt   4260

gatcttgctt tgaacgcaag cgaatcgcca gcggacattc agttccagct cacattcgca   4320

accaagctgt tcaagaaaga aacggtcgag cgaatggccc ggcattacct ggaaattttg   4380

cgctggatca gtgagcagcc aacggcaagc ctcgcggaca tcgacatgat gacggaagcg   4440

gaaaaacgca cactccttct gaacgtgaac gatacgtttg tcgagcggac tgccgcgacc   4500

gctttgcatc aattagtgga ggagcaagca gcacgcacgc ctgatgaagt ggccgtcgtg   4560

tacgaagaat atgccttgac ctatcgcgag ctgaacgcca gggcgaacca gctggcccgt   4620

ttgctgcgca gtcacggaac cggaccagat acgttgatcg gcattatggt ggaccgttcg   4680

ccaggcatgg tcgtcgggat gctggctgtg ctcaaagcag gcggcgcgta cacgccaatc   4740

gacccaagct atccgccaga acgaatccag tacatgctca gcgacagcca ggcgccgatt   4800

ttgctgacgc agcgtcattt gcaggagctg gctgcttatc aaggggagat catcgacgta   4860

gacgaggaag cgatttacac cggagccgac acgaacttgg acaacgtcgc tggcaaagac   4920

gacttggcct atgtgatcta cacatcggga tcgacgggca atccgaaagg cgtcatgatc   4980

tcccatcagg cgatttgcaa tcacatgttg tggatgagag agacgttccc gctgacgacc   5040

gaggatgctg tcctgcaaaa aacgccgttc agcttcgacg cttccgtatg ggagttttat   5100

ttgccgctca tcaccggagg acaactggtg ttggcaaagc cggacgggca tcgcgacatc   5160

gcctacatga ctcgtctcat tcgagatgag aaaatcacga ccttgcagat ggttccgtcc   5220

ttgctggatc tggtcatgac cgacccgggc tggagcgcat gcacgagctt gcagcgagtg   5280

ttctgcggcg gggaagcatt gacgcctgcc ctcgtctcgc gtttttacga gacacagcaa   5340

gctcagttga tcaacttgta cggccctaca gagacaacca tcgatgcgac ttattggcct   5400

tgcccgcgcc agcaggaata cagcgcaatt ccgatcggca aaccgatcga caacgtccgg   5460

ctgtatgtcg tcaatgccag caaccagctt cagccagtag gcgtagcggg agagctgtgc   5520

attgccggag acggtttggc ccgcggctat tggcagcgcg aggagctgac gaaagcaagt   5580

tttgtcgaca acccgtttga gccgggcggc accatgtacc gtaccggaga catggtccgc   5640

tatttgccag atggccatat cgagtatttg ggacgcatcg accatcaagt caaaatcaga   5700

ggtcaccgca tcgagctggg ggaaatcgaa gccacgcttt tgcagcatga agcggtcaaa   5760

gcggtcgtcg tcatggcccg ccaggatggc aaagggcaaa acagcctgta cgcctatgtc   5820

gtagcggagc aggacatcca gacagcggag ctgagaacgt acctgtctgc caccttgcca   5880

gcctacatgg ttccgtccgc ttttgttttc ttggagcagc tgccgctttc agcgaacggc   5940

aaagtggatc gcaaggcatt gcctcaaccg gaggatgccg ccgcctctgc tgccgtgtat   6000

gtggcgccgc gcaacgaatg ggaagccaag ctcgcagcga tatgggaaag tgtgcttgga   6060

gtcgagccga tcggggttca cgatcatttc tttgaactgg gcggacattc tttgaaagcg   6120

atgcacgtca tttctttgct ccagcgcagc ttccaggtgg acgtaccgtt gaaagtcctg   6180

tttgaatcgc caacgatcgc gggcctggcc ccacttgttg cggctgcccg caaaggcacg   6240

tacacagcga tcccccctgt cgaaaagcag gagtattacc cggtttccgc ggcacagaag   6300

cgaatgttca ttctgcagca aatggaagga gcaggtatca gctacaacat gccaggcttc   6360

atgtatctcg acggcaagct ggatacagag cggctgcaac aggcgctgaa aagtttggtg   6420

caacgccacg aatcgttgcg cacctcgttc cactccgtgc aaggcgagac ggttcagcgt   6480

gtgcatgacg atgtcgatct ggccatctcg tttggcgaag cgaccgaagc agagacccgg   6540

caaatagccg agcagtttat ccagccgttc gatctgggaa cagccccgct gttgcgtgcc   6600

ggactcatca agctggcgcc ggaacgccac ctgttcatgc tcgatttgca ccatattgtc   6660

gtcgatggcg tctccatcgg cctgctcatc gaggaatttg cccagctcta tcacggggaa   6720

gagctgccag cgctgcgcat tcagtacaaa gattttgcca agtggcagca ggactggttc   6780

cagaccgagg aatttgccga gcaggaagcc tactggctca acacctttac gggagaaatc   6840

cccgtgctta atctgccgac ggattatcca agaccgtctg tgaaaagctt tgcgggagat   6900

cgcttcgtct ttggctccgg cactgctttg ccaaaacaat tgcatcagct cgcccaagag   6960

acaggcacga cgctctacat ggttctgttg gccgcctaca acgtgctcct gtccaaatac   7020

tccaggcaag aggacatcat cgtcggcgct cctacggctg gcaggtccca tgccgaaacg   7080

gagtccatcg tcggaatgtt tgtcaacaca ctggccttgc gcaacgagcc agccgggggc   7140

aaaactttcc gcgacttttt ggccgaagtg aaaatcaata cgttgggagc gtttgagcat   7200

caagattatc cgctcgatga actcgtcgac aagctggaca tgcaacggga tttgagccgc   7260

aaccctttgt ttgacacggt tttcattttg caaaacatgg agcaaaagcc gttcgaaatg   7320

gagcagttga cgattactcc ttattcggca gaggtgaaac aggccaagtt tgacctgtcg   7380

ctggaggcgt acgaagaaaa cgcggaaatc atctttagcc tggattacag caccaagctg   7440

ttttcgcgcg agacgatcga aaaaatagcg acccatttta tccaaatctt gcgggcggtc   7500

attgcggaac cggaaatgcc gttgtccgag atcaccatgc tcacagaggc ggaaaagcag   7560

cgcttgctgg tcgacttcaa cggtgcgcac aaagattttc cgcaaaacaa aacgcttcag   7620

gcgctttttg aagaacaagc ggaaaagtcg ccgcaggcaa cagccgtgga aatcagcggg   7680

cagcccctgt cctatcagga gctgaatgag cgagccaacc agcttgccgc tacgctgcgg   7740

gagcggggag tacagcctga ccaacctgta gggattatgg cgaaccgctc tgtggagatg   7800

gtcgtcggca tcctcgccat cttgaaagca ggcggagctt acgtgccgat cgacccggaa   7860

tatccggagg agcgtgtcgc ctacatgctg acggattgcc aagcccgcct ggtgctgacg   7920

caaaagcatc tgggagcgaa gcttggttcc agcgtgaccg cggaatgcct gtatctcgac   7980

gacgagagca actatggtgt gcaccgctcg aatttgcagc cgatcaatac cgcttccgat   8040

ctggcttaca tcatctacac atcgggtacg actggcaagc caaaaggggt catggtcgag   8100

caccggggca tcgtcaacaa cgtgctgtgg aagaaagcgg agtaccaaat gaaggttggc   8160

gacagaagct tgctgtctct gtcctttgcc tttgacgctt tcgttctgtc cttctttacg   8220

cctgtgcttt ccggggcaac tgtcgtactg gcggaggatg aagaagccaa ggacccagtc   8280

tctttgaaaa agctcatcgc cgcttcgcgc tgcaccttga tgacaggcgt gccgagcttg   8340

ttccaggcca ttctggaatg cagcacgcca gcggatatcc gtccgctgca aaccgtcaca   8400

ctcggcggag aaaaaattac ggcgcagctt gttgaaaaat gcaagcagct gaatcccgat   8460

ctggtcatcg tcaacgagta cggcccgaca gaaagcagtg tcgtcgccac ctggcagcgc   8520

cttgcgggtc cggatgctgc catcaccatc gggcggccga ttgccaacac cagcctgtac   8580

atcgtgaacc aatatcacca gctacagcca atcggcgtgg tcggggagat ttgcatcggc   8640

ggccgcggct tggcacgagg ctattggaac aagccagcgc tcacggaaga gaagttcgtt   8700

tcccatccgt ttgcggcagg cgagcgcatg tacaagacgg gcgatcttgg caagtggctc   8760

ccggacggaa cgattgaata cattgggcgc atcgacgaac aggtcaaagt ccgaggctac   8820

cgaattgaaa tcggcgagat cgagtcggct ctgctggctg cggaaaagct gacagcggct   8880

gttgtggtcg tctatgagga tcagcttggc cagtcggctc tggcagcgta ttttaccgcc   8940

gacgaacagc ttgatgtcac gaagctgtgg tcgcatctgt cgaagcgact cccgtcgtac   9000

atgattcctg cgcattttgt gcagctcgat cagcttccgc ttacgccaaa cggcaaagtc   9060

gacaagaaag ccttgccgaa gccagaaggc aagcccgtaa ccgaagcgca atatgtcgcg   9120

ccgacaaatg cggtggaaag caagctggca gagatttggg aacgcgtgct cggggttagc   9180

ggcatcggca ttctcgacaa ctttttccag atcggcggac attccttgaa agcgatggct   9240

gtcgctgcac aggtgcatcg cgagtatcag gttgagcttc cgctgaaagt gctgttcgcg   9300

cagcctacga tcaaggcgtt ggcccagtat gtcgccacga gcggaaaaga gacgtatgtg   9360

ccgatcgagc ctgcaccgtt gcaagagtat tatcctgttt catctgcgca aaagcggatg   9420

tatgtcctgc gccagtttgc ggacacaggc acggtttata acatgccgag cgcgttgtat   9480

atcgaaggcg atctggatcg gaagcgtttt gaagccgcca tccacggatt ggtcgagcgg   9540

cacgaatcgc tgcgcacatc cttccacacc gtaaatggcg agcctgtcca gcgcgtacac   9600

gagcatgtcg agctgaatgt gcagtacgcg gaagtgacgg aagcgcaagt ggagccaacc   9660

gtcgagtcgt tcgtgcaagc atttgatctg acaaaagctc cgctattgcg ggtcggactt   9720

ttcaagctgg cagcgaaacg gcatctgttc ctgctggata tgcatcacat catctcggat   9780

ggcgtctcgg ccggaatcat tatggaagag ttctcgaagc tgtatcgagg cgaagaactg   9840

cctgcgcttt ccgtccatta caaagatttc gccgtctggc agtctgaact gttccagagc   9900

gacgtctata ccgagcatga aaactactgg ctgaacgcgt tttctggcga cattccggtg   9960

cttaacttgc cagccgattt ttctcgtccg ctgacacaga gctttgaagg agattgcgtt  10020

tcgttccagg cagacaaagc gttgctggac gatcttcaca agctcgctca ggagagccaa  10080

tcgacgttgt tcatggtatt gctggcggct tacaatgtgc tgcttgccaa gtacagcgga  10140

caggaagaca tcgtcgtcgg cacaccgatt gcgggcagat cgcacgccga tatcgagaac  10200

gttctgggga tgtttgtcaa cacgctcgct ttgcgcaact atccggtcga gacgaaacac  10260

ttccaggcat ttttggaaga ggtcaagcaa aatacgctgc aagcatacgc ccatcaagat  10320

tatccgttcg aagcactggt cgaaaagctg gacatccagc gggatctcag ccgcaatccg  10380

ctgtttgaca ccatgtttat tttgcaaaac ctggaccaaa aagcttacga gctggatggg  10440

ctgaaactgg aggcatatcc ggcacaagca ggcaacgcca aattcgatct cacgctggaa  10500

gcgcacgagg acgagacagg cattcatttt gcgctcgtct actcgaccaa attgttccag  10560

cgagaatcaa tcgaaagaat ggcgggtcac ttcctgcaag tgctgcgcca agtcgttgcc  10620

gaccaagcaa ctgccttgcg cgagatcagc ctgctcagcg aggaagagcg ccgaattgtg  10680

accgttgatt tcaacaacac gtttgccgcg tatccgcgcg atctgacgat tcaggagctg  10740

ttcgagcagc aggcagcaaa aactccggag catgcagcgg tcgtgatgga cggacagatg  10800

ctgacgtatc gggagctgaa cgaaaaagcg aaccagctcg cccatgtcct tcgtcaaaac  10860

ggagtcggga aagagagcat cgtcggtctg ctcgcagatc gttcgctgga aatgattaca  10920

ggcatcatgg ggattctcaa agcgggcggc gcctacctgg gactggaccc ggagcatccg  10980

tccgaacgcc tggcttacat gttggaagat ggcggcgtga aagttgtcct cgtgcaaaag  11040

cacttgctgc cgctcgtcgg cgaagggctg atgccaatcg ttttggaaga ggagagcctg  11100

cgcccggaag attgcggcaa tccggcgatt gtcaacggtg cgagtgacct ggcttatgtg  11160

atgtacacct caggctctac aggcaagcca aaaggagtca tggtcgagca tcgcaacgtc  11220

acccgcttgg tcatgcatac gaattacgtg caagtgcgcg agagcgaccg gatgattcaa  11280

accggcgcga ttggcttcga cgccatgaca tttgagattt ttggagcctt gctgcacggg  11340

gccagcctgt atttggtgag caaggacgtc ttgctggatg ccgaaaagct gggcgacttc  11400

ctgcggacga atcagattac gaccatgtgg ctgacctcgc cgctcttcaa ccagctttcg  11460

caagacaatc cggcgatgtt tgacagcttg cgcgccttga tcgtcggtgg cgaagcgttg  11520

tcgccgaagc acatcaaccg ggtaaaaagt gcccttcctg acctggaaat ctggaacgga  11580

tacggcccga ccgaaaacac gaccttctcg acgtgctatt tgattgagca gcattttgaa  11640

gagcagattc cgatcggcaa gccgattgca aactccaccg cgtatatcgt cgacggcaac  11700

aatcagccgc agccgatcgg cgtaccgggt gaactgtgcg tcggtggtga cggtgtcgca  11760

agaggctatg tgaacaagcc ggaattaacc gccgaaaagt ttgtgcccaa tccgtttgcg  11820

cctggcgaaa cgatgtatcg caccggagat ttggcgagat ggctgccgga tgggacgatt  11880

gagtatttgg gccgaatcga ccagcaggtc aaaatcaggg gataccggat cgagcttggg  11940

gaaatcgaga cggtcttgtc ccagcaggca caagtaaaag aagcagtcgt ggccgtgatc  12000

gaggaggcga acgggcaaaa agctctctgc gcttactttg tgccagaaca ggccgtcgac  12060

gccgcagagc tgcgagaagc gatgtccaaa caattgcctg gctacatggt ccctgcttac  12120

tatgtgcaaa tggaaaagct gccgttgacc gcgaacggaa aggtcgaccg ccgggcattg  12180

ccgcagccat ccggcgagcg gacgacagga agcgcctttg tcgctgcgca aaatgatacc  12240

gaagcgaagc tgcaacagat ttggcaagaa gttttgggca ttccggcaat cggcattcac  12300

gacaacttct ttgaaatcgg cggtcattcc ttgaaggcga tgaacgtcat cacgcaagtc  12360

cataaaacat tccaggtgga gctgccgtta aaagcgctgt ttgccactcc gacgatccat  12420

gagttggctg cgcatattgc cgagagcgca ttcgagcagt tcgagacgat ccagccagtc  12480

gagcctgccg cgttttatcc cgtgtcgttt gcccaaaagc gaatgtacat cctgcatcag  12540

ttcgaaggaa gcgggatcag ctacaacgtg ccgagtgtgc tggtgctgga aggcaagctc  12600

gattatgacc gctttgctgc tgccatccag agcctggtta aacggcatga atctttgcgc  12660

acctcgttcc attcggtaaa cggggaaccg ctgcaacgag tacatccgga tgtcgagctg  12720

cctgtccgcc ttttggaggc gacagaagat cagagcgaat cgctcatcca ggagctaatc  12780

cagccgtttg atctggagat agccccgttg ttcagagtga atctgatcaa gcttggcgca  12840

gagcggcact tgttcttcat ggatatgcac cacattattt ccgatggcgt atcgcttgcg  12900

gtcatcgtcg aggaaattgc cagcttgtat gcaggaaaac agctttccga cctgcgcatc  12960

cagtacaaag actttgctgt gtggcagacc aagctggctc agtcggatcg cttccaaaaa  13020

caggaggatt tttggacccg gacgtttgcc ggggagattc ctttgctgaa tctgccccat  13080

gattatccaa gaccttctgt gcagagcttt gacggtgaca cggtcgcgct tggcaccgga  13140

catcacctgc tggaacaact gcgcaagctc gctgccgaga ctggcacgac cttgttcatg  13200

gtgctgctgg ctgcctacca tgtgttgctc tccaagtacg ccggacagga agaaatcgtc  13260

gtcggcacac cgatcgcagg ccgctcgcac gcagatgtcg agcgcattgt cgggatgttc  13320

gtcaacacgc tcgctttgaa aaatacggcc gctggcagcc tgagcttccg cgcctttttg  13380

gaagacgtga agcaaaatgc gctccatgcc ttcgagcatc aagactatcc gttcgagcat  13440

ctggtcgaga agctgcaagt gcggcgcgat ctgagcagaa acccgctgtt tgatacgatg  13500

ttcagcctgg ggcttgccga atcagccgaa ggagaagtag cggatctgaa agtgtcgcct  13560

tatccggtga acggccacat cgccaaattc gacctttccc tggatgcgat ggaaaaacag  13620

gatggacttc ttgttcaatt cagctattgc acgaagctgt tcgcaaaaga aacggttgat  13680

cgactggccg cccattacgt tcagcttttg caaacaatca cagccgatcc cgacatcgag  13740

ctcgcccgga tcagcgtgtt gtccaaagca gagacggagc acatgctgca cagcttcctc  13800

gcaaccaaaa cagcctatcc gacggacaaa acgttccaga agctgttcga ggagcaagtg  13860

gaaaaaacac cgaacgagat tgccgttctg ttcggcaatg aacagctgac ctatcaggag  13920

ttgaatgcaa aagcaaacca gctcgcccgc gtcctgcggc gaaaaggcgt caagccggag  13980

agcaccgtcg gcatcctcgt agaccgctcg ctctacatgg tcatcggcat gctggccgtg  14040

ttgaaagcag gcggaacatt cgtcccgatt gatccggact acccgctgga gcgccaagcg  14100

ttcatgctcg aagacagcga ggcgaagctg ctgctcacct tgcaaaaaat gaacagtcaa  14160

gttgccttcc cttatgaaac cttttatctg gatacagaga cagtggatca ggaggagacg  14220

ggcaatctgg agcacgttgc gcagccggag aacgtcgctt acatcatcta cacatccggt  14280

acgacgggca agccaaaagg ggtcgtcatc gagcaccgca gctatgccaa tgtcgcattt  14340

gcctggaaag acgaatatca cctggacagc ttcccggtcc gtttgctgca aatggcgagc  14400

ttcgcctttg acgtctcgac gggcgatttt gccagggcgc tgctgacagg cgggcaactg  14460

gtcatctgcc cgaatggggt caaaatggac ccagcttcgc tgtacgagac catcaggcgt  14520

cacgaaatta ccattttcga agcgacaccc gccttgatca tgccgttgat gcactacgtt  14580

tacgaaaacg aactggatat gagccaaatg aagctgctga ttctcggagc agacagctgc  14640

ccggcggaag acttcaaaac gttgctcgcg cgcttcggtc agaagatgcg cattatcaac  14700

agctacggcg tgacagaggc gtgcattgac accagctact acgaagaaac agacgtcacc  14760

gccatccgct cgggaacggt gccgatcggc aaaccgcttc cgaacatgac gatgtacgtg  14820

gtcgatgcgc atttgaattt gcagcctgtc ggcgtcgtag gcgaattgtg catcggcgga  14880

gcaggggttg cgcgcggtta tttgaacaga cctgagctga cggaagagaa gttcgtgccg  14940

aatccgttcg ccccaggtga acgattgtac cgcacaggtg atctggcgaa gtggcgcgca  15000

gatggcaatg tcgagttcct cggacgcaat gaccaccagg taaaaatcag gggtgtccgc  15060

atcgagctgg gcgagatcga gacacaactg cgcaagctgg acggaattac ggaagcagtc  15120

gtggttgcga gagaagatcg cgggcaggaa aaggaattgt gcgcatacgt cgtggcggac  15180

cacaagcttg acaccgcaga attgcgggcg aatttgctga aggaactgcc gcaagcgatg  15240

attccagcgt atttcgtcac cttggatgcg ctgccgctga ctgccaatgg caaagtagac  15300

agacgttcct tgccagcgcc ggatgtcacc atgctgagaa cgaccgagta tgtagcgccg  15360

cgctccgtct gggaagcccg attggcccaa gtatgggagc aggtgctgaa tgttccgcaa  15420

gtgggtgcgc tagacgactt tttcgcgctc ggcggtcact cattgcgtgc catgcgcgtc  15480

ctttccagca tgcacaacga ataccaggtc gacatcccgc tgcgcatctt gttcgaaaaa  15540

ccgacgattc aggaactggc ggcgttcatc gaagagacag ccaaagggaa tgtcttctcg  15600

atcgagcctg tgcaaaagca agcgtactat ccggtctcct cggcacaaaa gcgcatgtac  15660

atcctcgatc aatttgaggg agtcggcatc agctacaaca tgccgtcgac tatgctgatc  15720

gaaggcaagc tggagcgaac acgggtagaa gcggcgttcc agcgcttgat tgcgcgacat  15780

gaaagcctgc gcacttcgtt tgccgtcgtc aacggagagc ctgtgcaaaa cattcacgag  15840

gacgttccgt ttgcgcttgc ctattcggaa gtcacagaac aggaggcgcg cgaactcgtt  15900

tcttctctcg tgcagccgtt cgatctggag gtcgcaccac tcatccgcgt gtcgctgctg  15960

aaaatcggcg aggatcgtta cgtgctcttt accgacatgc atcacagcat ttccgatggc  16020

gtatcctccg gcattctttt ggcagagtgg gtgcagctgt accagggtga cgttttgccg  16080

gagctgcgta tccagtacaa ggactttgct gtgtggcaac aagagttttc ccagtcggct  16140

gccttccaca agcaggaagc gtactggttg caaacgtttg ccgatgacat tcctgtgctg  16200

aacttgccga ccgatttcac ccgccccagc acccaaagct ttgccgggga tcagtgcacg  16260

atcggcgcgg gcaaagcgct cacggaaggc ttgcaccagt tggcgcaggc gacgggaacg  16320

actttgtaca tggttttgct cgccgcgtac aacgtgctgc tcgccaagta tgccgggcag  16380

gaggacatca tcgtcggcac gccgattaca ggcagatccc atgccgatct cgaaccgatc  16440

gtcggcatgt tcgtgaacac cttggcgatg cgaaacaaac cgcagcgcga aaagactttt  16500

agcgagtttt tgcaagaagt caagcaaaat gcgctggatg cgtacggcca tcaggattac  16560

ccgtttgaag aactggtgga aaagctcgcg atcgcgcgcg atttgagccg aaatccgctg  16620

tttgacaccg tgtttacgtt ccaaaacagc acggaagagg tcatgacgct gcctgaatgc  16680

acgcttgcgc cgtttatgac ggacgaaaca ggccagcacg ccaagttcga cttgactttc  16740

agcgctacgg aagagcggga agaaatgacg attggcgtgg agtacagcac aagcttgttt  16800

acgcgggaaa cgatggaacg gttcagccgc cacttcctga cgattgcagc gagcatcgtg  16860

caaaatccgc acatccgtct gggcgagatc gacatgcttt tgccagaaga aaaacagcag  16920

attttggccg ggttcaacga tacggcagtc agctatgcgc tggacaaaac gctgcaccag  16980

ctattcgaag agcaggtcga caaaacaccg gatcaggcag cgcttctctt tagcgagcaa  17040

tcgctgacgt acagcgaact gaacgagcga gcaaacagac tggcaagggt cctgcgcgca  17100

aaaggagtcg gaccggaccg tctggtagcg atcatggcgg agcgctcgcc ggaaatggtg  17160

atcggtattc tcggtatttt gaaggcaggc ggcgcttatg ttcccgtcga tcccggctat  17220

ccgcaggagc gcattcagta cctgctcgaa gatagcaacg cagccctgct gctcagccag  17280

gcgcatctgt tgccgctgtt ggcccaggtg tcaagcgagc tgccggagtg ccttgatctg  17340

aacgctgaac tggatgccgg actgagcggc tccaacctgc cagctgtcaa ccaaccgact  17400

gaccttgcct acgtcatcta tacatccggt acgaccggca agccgaaggg tgtcatgatc  17460

ccgcatcaag gaatcgtgaa ctgcttgcag tggagaagag acgaatacgg gttcgggccg  17520

agtgacaagg cgttgcaagt gttctccttt gccttcgacg gttttgtagc cagcttgttc  17580

gctccgctgc tcggaggggc aacgtgcgtg ttgccgcaag aagcagctgc caaagacccg  17640

gtcgcgctga aaaaactgat ggccgcaacg gaagtcaccc attactacgg cgtaccgagt  17700

ctgttccagg ccattctcga ttgctcgacg acaaccgact tcaatcagtt gcgttgcgtc  17760

actttgggcg gcgagaagct gcctgtgcag cttgtgcaaa aaacaaaaga aaagcatccg  17820

gcaatcgaga tcaacaacga gtacggcccg acggaaaaca gcgtcgtcac caccatctcg  17880

cgctcgattg aagcggggca agcgatcacg attggccgac cgcttgcgaa cgtccaagtc  17940

tacattgtag atgagcagca tcacttgcag ccgattggcg tggtcggtga gctgtgcatc  18000

ggcggagccg ggcttgccag aggctatctg aacaaaccgg agctgaccgc agagaagttt  18060

gtcgcaaatc cgttccgacc aggcgagcgc atgtacaaaa caggcgactt ggtaaaatgg  18120

cggacggatg gcacgatcga gtacatcggc cgcgcagacg aacaggtcaa ggtgagaggg  18180

tatcgcatcg agatcggcga gatcgagagc gccgtactcg cttaccaggg catcgatcaa  18240

gcggtggtcg ttgcgcgaga cgatgacgct acggctggtt cctatctttg cgcctacttt  18300

gtcgcagcaa cagccgtgtc cgtatccggc ttgagaagcc atctggccaa agagctgcct  18360

gcttacatga ttccgagcta tttcgtcgag ctggatcagc tgccgctttc cgccaatgga  18420

aaagtggatc gcaaagcttt gccgaagccg caacagtccg atgcgaccac gcgcgaatac  18480

gtggccccga ggaatgcgac cgaacagcaa ctggcagcca tctggcaaga agttttggga  18540

gtagagccaa tcggcatcac cgaccagttc tttgaactcg gaggacattc cttaaaagct  18600

acgctgttga ttgccaaagt gtatgagtac atgcaaatcg agctgccgct gaatctcatc  18660

ttccagtatc cgacgatcga aaaggtggcc gatttcatca cgcataagcg ctttgagagc  18720

agatacggca cagccatttt gttaaatcag gagacggcgc gaaacgtatt ttgcttcacg  18780

ccgatcggcg cacaaagcgt gtactaccag aagcttgcgg cggaaattca aggcgtctct  18840

ttgtacagct ttgatttcat ccaggatgac aaccggatgg agcagtatat cgcggcgatc  18900

accgcaattg atccaagcgg tccgtacacg ctcatgggct actcctcggg aggcaatctg  18960

gcttttgaag tggcgaaaga actggaggag cggggctatg gcgtcaccga catcatcttg  19020

ttcgactcgt actggaaaga caaggcgatt gagcggactg tcgcggaaac agaaaacgac  19080

attgcccagc tattcgccga gattggcgaa aacaccgaga tgttcaacat gacgcaagaa  19140

gacttccagc tgtacgccgc caatgagttt gtcaagcaaa gcttcgttcg caaaacggtc  19200

agctatgtga tgttccataa caatctggtc aataccggaa tgaccactgc cgcgatccac  19260

ctcatccaat ccgagctgga agcagacgag gaagctccgg tggcagccaa gtggaacgaa  19320

tcagcctggg caaacgcaac gcaacgactg ctgacgtaca gcgggcacgg aatccactcg  19380

cgcatgctgg cgggcgatta cgcgtcgcaa aatgcttcga ttttgcaaaa catcctgcaa  19440

gaactgttca tcctgaaata a                                            19461


<210>  23
<211>  6507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS being a synthetase of a fusion peptide consisting of Valine 
       and Indigoidine. Due to its sterical advantages, Valine may be 
       used as a spacer for other tags.

<400>  23
atgtatccgc gcgatctgac gattcaggag ctgttcgagc agcaggcagc aaaaactccg     60

gagcatgcag cggtcgtgat ggacggacag atgctgacgt atcgggagct gaacgaaaaa    120

gcgaaccagc tcgcccatgt ccttcgtcaa aacggagtcg ggaaagagag catcgtcggt    180

ctgctcgcag atcgttcgct ggaaatgatt acaggcatca tggggattct caaagcgggc    240

ggcgcctacc tgggactgga cccggagcat ccgtccgaac gcctggctta catgttggaa    300

gatggcggcg tgaaagttgt cctcgtgcaa aagcacttgc tgccgctcgt cggcgaaggg    360

ctgatgccaa tcgttttgga agaggagagc ctgcgcccgg aagattgcgg caatccggcg    420

attgtcaacg gtgcgagtga cctggcttat gtgatgtaca cctcaggctc tacaggcaag    480

ccaaaaggag tcatggtcga gcatcgcaac gtcacccgct tggtcatgca tacgaattac    540

gtgcaagtgc gcgagagcga ccggatgatt caaaccggcg cgattggctt cgacgccatg    600

acatttgaga tttttggagc cttgctgcac ggggccagcc tgtatttggt gagcaaggac    660

gtcttgctgg atgccgaaaa gctgggcgac ttcctgcgga cgaatcagat tacgaccatg    720

tggctgacct cgccgctctt caaccagctt tcgcaagaca atccggcgat gtttgacagc    780

ttgcgcgcct tgatcgtcgg tggcgaagcg ttgtcgccga agcacatcaa ccgggtaaaa    840

agtgcccttc ctgacctgga aatctggaac ggatacggcc cgaccgaaaa cacgaccttc    900

tcgacgtgct atttgattga gcagcatttt gaagagcaga ttccgatcgg caagccgatt    960

gcaaactcca ccgcgtatat cgtcgacggc aacaatcagc cgcagccgat cggcgtaccg   1020

ggtgaactgt gcgtcggtgg tgacggtgtc gcaagaggct atgtgaacaa gccggaatta   1080

accgccgaaa agtttgtgcc caatccgttt gcgcctggcg aaacgatgta tcgcaccgga   1140

gatttggcga gatggctgcc ggatgggacg attgagtatt tgggccgaat cgaccagcag   1200

gtcaaaatca ggggataccg gatcgagctt ggggaaatcg agacggtctt gtcccagcag   1260

gcacaagtaa aagaagcagt cgtggccgtg atcgaggagg cgaacgggca aaaagctctc   1320

tgcgcttact ttgtgccaga acaggccgtc gacgccgcag agctgcgaga agcgatgtcc   1380

aaacaattgc ctggctacat ggtccctgct tactatgtgc aaatggaaaa gctgccgttg   1440

accgcgaacg gaaaggtcga ccgccgggca ttgccgcagc catccggcga gcggacgaca   1500

ggaagcgcct ttgtcgctgc gcaaaatgat accgaagcga agctgcaaca gatttggcaa   1560

gaagttttgg gcattccggc aatcggcatt cacgacaact tctttgaaat cggcggtcat   1620

tccttgaagg cgatgaacgt catcacgcaa gtccataaaa cattccaggt ggagctgccg   1680

ttaaaagcgc tgtttgccac tccgacgatc catgagttgg ctgcgcatat ttcggaaaaa   1740

accgagtaca ccgcgattca acccgtggca gcgcaggagt tttacccggt ttcatctgcg   1800

caaaaaagaa tgtatatcct gcaacagttc gaaggcaacg gaatcagcta caacatttcg   1860

ggtgcgattc tcctggaagg aaagctggac tacgcccggt ttgccagcgc tgtgcaacag   1920

ctggcagagc gccacgaagc tttgcgcacc tcgttccacc ggatcgacgg cgagcctgtg   1980

caaaaagtgc acgaggaagt agaagtgccg cttttcatgc tggaggctcc cgaagaccag   2040

gcggagaaaa tcatgcgcga gtttgtccgt ccgtttgatc tcggggtcgc tccgctgatg   2100

cgaacaggtt tgctcaagct gggcaaagac cgccatttgt ttttgctcga catgcaccat   2160

atcatctcgg acggcgtttc ttcgcaaatt ttgctgcgtg aatttgccga gttgtaccag   2220

ggagcagact tgcagccgct ttcgctgcaa tacaaagatt tcgctgcttg gcaaaatgag   2280

ctgtttcaga cggaggcata caagaagcag gagcagcact ggctgaacac gtttgctgat   2340

gaaattccgc tcttgaacct gccgactgac tatccgcgcc ctagcgtgca aagctttgca   2400

ggcgatctcg tcctttttgc cgccggaaaa gaactgctgg agcggttgca acaggtagcg   2460

tcagaaacag gcaccacctt gtacatgatt ttgcttgccg cctacaatgt gctgctgtcc   2520

aagtataccg gccaggaaga catcatcgtc gggacgcctg tcgctggacg ttcccatgcg   2580

gacgtggaaa acatcatggg catattcgtg aacacattgg cgctgcgcaa ccagcctgcc   2640

agcagcaaaa cgatgttaga aaataatatt acacaatgtg actcaatcaa tgatgtttat   2700

cttaaagaag aagcaataac attgatggat atgcttgaga gtcaacttaa gcaccaggca   2760

gatggatatg ttgttattga tcaagaagaa tctctcagtt acgctgattt ctatttgagg   2820

gtgaaagaga tagggtattg tctgtcagaa attagctcaa agagttcggt gggtattggg   2880

cttttttgtg atccttctat agatttaatt tgtggtgcat ggggtatttt gtcagcggat   2940

aaagcttatt tgccgttatc gcctgactat ccaactgaac gcctcaaata tatgatagaa   3000

gattctggta ttgatgtgat ttttacgcaa tcgcacttaa aagcacagct acaggacatt   3060

gcaccaaaat cagtattaat tatgacacca gaagatgtcg ctctgacgat aaaaacacga   3120

acaatagaag atattctggg cacagttcaa gttcctaaac ccacgagtct ggcttatatt   3180

atttatacct ctggtagcac gggtaagcca aagggagtga tgattgaaca tcacagtatt   3240

gtaaatcaaa tgagatttct tgcaaaagcg ttcaaattag gatgtcattc ccggatttta   3300

cagaaaacac caatgagttt tgatgcggct caatgggaaa ttctagcgcc tgcaattggt   3360

ggtcaagtga ttatgggtcc tttaggttgc tatcgcgatc cggatgcaat tattaaaacc   3420

attcttcagc atcaagtaac gactttgcaa tgtgttccta ctttgctaca agcgttactg   3480

gataatccta attttttgga ttgcttatca ttgactcaag tattcagtgg gggagaagcg   3540

ctgacaacca aattagccac gcaatttttg aatagtttta ctcactgtga attaatcaat   3600

ttatatggcc cgacagaatg tacgattaat tcatcatttt tccgggtgac aaatgagact   3660

ttgccgaatt atcaaacctc tatttcgatt ggtgcacctg tagataatac cgaatactac   3720

gttcttgatg atgatagatt acctgtggcg gttggcgaaa ttggcgagct ttatatttcg   3780

ggtgctcaat tagcacgtgg ttatttgcat aaaccagaaa tgacaaaaga taaatttatt   3840

tgtaatcacc ttgtatcagg aactcaacat caatggttat atcgaacggg agatctggta   3900

accagagggg ctgatggtaa tacttatttt gttggtcggg ttgatagcca ggtcaaatta   3960

cgaggttacc gtattgagct tgatgaaata cgccatgcga ttgaagaaca tagctggata   4020

aagacggcgg caatgttaat taagaaggat gccagaacgg gtttccaaaa tctcatcgcg   4080

tgtgtggaat tagatgagaa agaagctgca ttgatggatc aaggtaatag tagctcacat   4140

cacaaatcaa aagccgataa actacaggtg aaagcccaac tttctaattc tggttgtcga   4200

agtgaagagt tatgtgaaaa tcgccctaca ttcttacttc cttatcaaga aggggagata   4260

aaacagagag aatatgcatt tggacgcaag acatatcgct attttgaggg aacagaaata   4320

acggtagaga aattaaaaaa attgctgaca gccactcaat cgaatgaaat tagctctttg   4380

ccactgagtc atctaaccct gaatgatttc ggttatgcat tgcgttattt tggtcagttt   4440

accagccatc aacgtttatt gcccaaatat gcctatgctt caccgggtgc tctctatgcg   4500

acacaaatgt attttgaatt gcataatgtt ctcggtttgg atgcggggat ttactattat   4560

catccagtga cacataagtt aataaaaatt tcaacattga gtcgtcggca aatgccaacg   4620

ataaaagtgc attttattgg caagcatgaa gccattgagc ccgtttataa gaacaatata   4680

caagaagttc tggaaatgga agcgggccat atgatgggtc tttttgatga cgtattaccg   4740

gaaattggct tgagtattgg taaaagtgaa tatcaagatg aatgtccaga ttggtatgat   4800

ggtgatattc aggattatta tcttggtgca tttgaaatat gtagctatga acatggattg   4860

ccgccatttg agactgatat ttatttacaa acacatgccc ataaaatacc tgagatgccg   4920

tgtggtttat atcacttttc taacggggaa tttgtacgaa taagtgatga tattgtccga   4980

aaaaaggatg ttattgcgat taatcagcaa gtttatgatc gctccagttt tggcgtgtca   5040

attattccac gctgtgtccc tgaatggcat tattatataa cactgggtcg tcggttacat   5100

gcgttacaaa gtaatccatt gtatattgga ttaatgtcat ctggttacag ttcgaagagc   5160

aataacgatt taccttcggc gaaaaggatg cgatctattc tcaatgcact tgatagacct   5220

atggcggcat tttatttctg cataggtggg ggtattagcc aagcgcaata tatgtgtgaa   5280

ggcatgaaag aagatgttgt tcatatgaaa gggccagttg aaatcattaa agatgatctt   5340

caacaacaac tccctcaata tatgattcca aataaggtat tagttttcga taaattacct   5400

ttgacggcca atggaaaagt ggattatcaa tctttatcag aatctaaagc cgtggagaat   5460

gtttcaacac agcgtctatt ggtgccatta catacagata ctgaaataag gcttggaaaa   5520

atttggatgg aagtactgaa atgggattca gtatctgccc tcgatgattt tttcgaaagt   5580

gggggtaatt ctttgatggc cgttgcaatg gttaataaga tcaatgcggc ctttaatatt   5640

cgttttccgt tacagatact ttttcaatct cctaatatag cagaattggc taagtggatt   5700

gaacagacag actctaaaac aatatcaaga ttaattttat tgaatcaggc aagcaaagac   5760

cccatttact gttggccggg tttgggcgga tatcctatga gtttgagatt gcttgctaat   5820

aaagtcgttc ctgatcgggc attttatgga atacaggcat atgggataaa cgagagtgaa   5880

ataccgtttt cttctatcca gagaatggca gaagaggata ttaaagagat aaagaaaata   5940

cagccagaag ggccatatat attgtgggga tattcatttg gtgcccgagt agcatttgaa   6000

gttgcatacc agcttgaaca agcgggagaa gaagttaacg cattgaattt attggctccg   6060

ggatctcctc atcttgatat gaagcaagcg gaatatatgg ataaaggcgc tgaatttact   6120

aatccggctt ttgttaaaat acttttttct gtattttctc gttcaatcaa cagcccaatg   6180

gttaaaactt gcttagaaca agtaaatagt gaaacgacat ttattaactt tatatgtagt   6240

cgttttaaaa acttggaacc atcattagta aaacgtatcg ttaggattgt gactttgact   6300

tatgatttca agtacagtat tgatgagctt tatcacagac acctaaaggc acctataact   6360

attttcaagg cgaatagaga taatgattca tttatcgagg aatcggatgt gatttcatca   6420

atgtcgccta aaataattga attaatatcg gatcactatc aactgttgga aagtgaaggt   6480

gttgctgaga ttgagaaaat aatctaa                                       6507


<210>  24
<211>  9609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Indigoidine-tagged Dipeptide consisting of 
       two Valine-monomers.

<400>  24
atgtatccgc gcgatctgac gattcaggag ctgttcgagc agcaggcagc aaaaactccg     60

gagcatgcag cggtcgtgat ggacggacag atgctgacgt atcgggagct gaacgaaaaa    120

gcgaaccagc tcgcccatgt ccttcgtcaa aacggagtcg ggaaagagag catcgtcggt    180

ctgctcgcag atcgttcgct ggaaatgatt acaggcatca tggggattct caaagcgggc    240

ggcgcctacc tgggactgga cccggagcat ccgtccgaac gcctggctta catgttggaa    300

gatggcggcg tgaaagttgt cctcgtgcaa aagcacttgc tgccgctcgt cggcgaaggg    360

ctgatgccaa tcgttttgga agaggagagc ctgcgcccgg aagattgcgg caatccggcg    420

attgtcaacg gtgcgagtga cctggcttat gtgatgtaca cctcaggctc tacaggcaag    480

ccaaaaggag tcatggtcga gcatcgcaac gtcacccgct tggtcatgca tacgaattac    540

gtgcaagtgc gcgagagcga ccggatgatt caaaccggcg cgattggctt cgacgccatg    600

acatttgaga tttttggagc cttgctgcac ggggccagcc tgtatttggt gagcaaggac    660

gtcttgctgg atgccgaaaa gctgggcgac ttcctgcgga cgaatcagat tacgaccatg    720

tggctgacct cgccgctctt caaccagctt tcgcaagaca atccggcgat gtttgacagc    780

ttgcgcgcct tgatcgtcgg tggcgaagcg ttgtcgccga agcacatcaa ccgggtaaaa    840

agtgcccttc ctgacctgga aatctggaac ggatacggcc cgaccgaaaa cacgaccttc    900

tcgacgtgct atttgattga gcagcatttt gaagagcaga ttccgatcgg caagccgatt    960

gcaaactcca ccgcgtatat cgtcgacggc aacaatcagc cgcagccgat cggcgtaccg   1020

ggtgaactgt gcgtcggtgg tgacggtgtc gcaagaggct atgtgaacaa gccggaatta   1080

accgccgaaa agtttgtgcc caatccgttt gcgcctggcg aaacgatgta tcgcaccgga   1140

gatttggcga gatggctgcc ggatgggacg attgagtatt tgggccgaat cgaccagcag   1200

gtcaaaatca ggggataccg gatcgagctt ggggaaatcg agacggtctt gtcccagcag   1260

gcacaagtaa aagaagcagt cgtggccgtg atcgaggagg cgaacgggca aaaagctctc   1320

tgcgcttact ttgtgccaga acaggccgtc gacgccgcag agctgcgaga agcgatgtcc   1380

aaacaattgc ctggctacat ggtccctgct tactatgtgc aaatggaaaa gctgccgttg   1440

accgcgaacg gaaaggtcga ccgccgggca ttgccgcagc catccggcga gcggacgaca   1500

ggaagcgcct ttgtcgctgc gcaaaatgat accgaagcga agctgcaaca gatttggcaa   1560

gaagttttgg gcattccggc aatcggcatt cacgacaact tctttgaaat cggcggtcat   1620

tccttgaagg cgatgaacgt catcacgcaa gtccataaaa cattccaggt ggagctgccg   1680

ttaaaagcgc tgtttgccac tccgacgatc catgagttgg ctgcgcatat tgccacgagc   1740

ggaaaagaga cgtatgtgcc gatcgagcct gcaccgttgc aagagtatta tcctgtttca   1800

tctgcgcaaa agcggatgta tgtcctgcgc cagtttgcgg acacaggcac ggtttataac   1860

atgccgagcg cgttgtatat cgaaggcgat ctggatcgga agcgttttga agccgccatc   1920

cacggattgg tcgagcggca cgaatcgctg cgcacatcct tccacaccgt aaatggcgag   1980

cctgtccagc gcgtacacga gcatgtcgag ctgaatgtgc agtacgcgga agtgacggaa   2040

gcgcaagtgg agccaaccgt cgagtcgttc gtgcaagcat ttgatctgac aaaagctccg   2100

ctattgcggg tcggactttt caagctggca gcgaaacggc atctgttcct gctggatatg   2160

catcacatca tctcggatgg cgtctcggcc ggaatcatta tggaagagtt ctcgaagctg   2220

tatcgaggcg aagaactgcc tgcgctttcc gtccattaca aagatttcgc cgtctggcag   2280

tctgaactgt tccagagcga cgtctatacc gagcatgaaa actactggct gaacgcgttt   2340

tctggcgaca ttccggtgct taacttgcca gccgattttt ctcgtccgct gacacagagc   2400

tttgaaggag attgcgtttc gttccaggca gacaaagcgt tgctggacga tcttcacaag   2460

ctcgctcagg agagccaatc gacgttgttc atggtattgc tggcggctta caatgtgctg   2520

cttgccaagt acagcggaca ggaagacatc gtcgtcggca caccgattgc gggcagatcg   2580

cacgccgata tcgagaacgt tctggggatg tttgtcaaca cgctcgcttt gcgcaactat   2640

ccggtcgaga cgaaacactt ccaggcattt ttggaagagg tcaagcaaaa tacgctgcaa   2700

gcatacgccc atcaagatta tccgttcgaa gcactggtcg aaaagctgga catccagcgg   2760

gatctcagcc gcaatccgct gtttgacacc atgtttattt tgcaaaacct ggaccaaaaa   2820

gcttacgagc tggatgggct gaaactggag gcatatccgg cacaagcagg caacgccaaa   2880

ttcgatctca cgctggaagc gcacgaggac gagacaggca ttcattttgc gctcgtctac   2940

tcgaccaaat tgttccagcg agaatcaatc gaaagaatgg cgggtcactt cctgcaagtg   3000

ctgcgccaag tcgttgccga ccaagcaact gccttgcgcg agatcagcct gctcagcgag   3060

gaagagcgcc gaattgtgac cgttgatttc aacaacacgt ttgcctatcc gcgcgatctg   3120

acgattcagg agctgttcga gcagcaggca gcaaaaactc cggagcatgc agcggtcgtg   3180

atggacggac agatgctgac gtatcgggag ctgaacgaaa aagcgaacca gctcgcccat   3240

gtccttcgtc aaaacggagt cgggaaagag agcatcgtcg gtctgctcgc agatcgttcg   3300

ctggaaatga ttacaggcat catggggatt ctcaaagcgg gcggcgccta cctgggactg   3360

gacccggagc atccgtccga acgcctggct tacatgttgg aagatggcgg cgtgaaagtt   3420

gtcctcgtgc aaaagcactt gctgccgctc gtcggcgaag ggctgatgcc aatcgttttg   3480

gaagaggaga gcctgcgccc ggaagattgc ggcaatccgg cgattgtcaa cggtgcgagt   3540

gacctggctt atgtgatgta cacctcaggc tctacaggca agccaaaagg agtcatggtc   3600

gagcatcgca acgtcacccg cttggtcatg catacgaatt acgtgcaagt gcgcgagagc   3660

gaccggatga ttcaaaccgg cgcgattggc ttcgacgcca tgacatttga gatttttgga   3720

gccttgctgc acggggccag cctgtatttg gtgagcaagg acgtcttgct ggatgccgaa   3780

aagctgggcg acttcctgcg gacgaatcag attacgacca tgtggctgac ctcgccgctc   3840

ttcaaccagc tttcgcaaga caatccggcg atgtttgaca gcttgcgcgc cttgatcgtc   3900

ggtggcgaag cgttgtcgcc gaagcacatc aaccgggtaa aaagtgccct tcctgacctg   3960

gaaatctgga acggatacgg cccgaccgaa aacacgacct tctcgacgtg ctatttgatt   4020

gagcagcatt ttgaagagca gattccgatc ggcaagccga ttgcaaactc caccgcgtat   4080

atcgtcgacg gcaacaatca gccgcagccg atcggcgtac cgggtgaact gtgcgtcggt   4140

ggtgacggtg tcgcaagagg ctatgtgaac aagccggaat taaccgccga aaagtttgtg   4200

cccaatccgt ttgcgcctgg cgaaacgatg tatcgcaccg gagatttggc gagatggctg   4260

ccggatggga cgattgagta tttgggccga atcgaccagc aggtcaaaat caggggatac   4320

cggatcgagc ttggggaaat cgagacggtc ttgtcccagc aggcacaagt aaaagaagca   4380

gtcgtggccg tgatcgagga ggcgaacggg caaaaagctc tctgcgctta ctttgtgcca   4440

gaacaggccg tcgacgccgc agagctgcga gaagcgatgt ccaaacaatt gcctggctac   4500

atggtccctg cttactatgt gcaaatggaa aagctgccgt tgaccgcgaa cggaaaggtc   4560

gaccgccggg cattgccgca gccatccggc gagcggacga caggaagcgc ctttgtcgct   4620

gcgcaaaatg ataccgaagc gaagctgcaa cagatttggc aagaagtttt gggcattccg   4680

gcaatcggca ttcacgacaa cttctttgaa atcggcggtc attccttgaa ggcgatgaac   4740

gtcatcacgc aagtccataa aacattccag gtggagctgc cgttaaaagc gctgtttgcc   4800

actccgacga tccatgagtt ggctgcgcat atttcggaaa aaaccgagta caccgcgatt   4860

caacccgtgg cagcgcagga gttttacccg gtttcatctg cgcaaaaaag aatgtatatc   4920

ctgcaacagt tcgaaggcaa cggaatcagc tacaacattt cgggtgcgat tctcctggaa   4980

ggaaagctgg actacgcccg gtttgccagc gctgtgcaac agctggcaga gcgccacgaa   5040

gctttgcgca cctcgttcca ccggatcgac ggcgagcctg tgcaaaaagt gcacgaggaa   5100

gtagaagtgc cgcttttcat gctggaggct cccgaagacc aggcggagaa aatcatgcgc   5160

gagtttgtcc gtccgtttga tctcggggtc gctccgctga tgcgaacagg tttgctcaag   5220

ctgggcaaag accgccattt gtttttgctc gacatgcacc atatcatctc ggacggcgtt   5280

tcttcgcaaa ttttgctgcg tgaatttgcc gagttgtacc agggagcaga cttgcagccg   5340

ctttcgctgc aatacaaaga tttcgctgct tggcaaaatg agctgtttca gacggaggca   5400

tacaagaagc aggagcagca ctggctgaac acgtttgctg atgaaattcc gctcttgaac   5460

ctgccgactg actatccgcg ccctagcgtg caaagctttg caggcgatct cgtccttttt   5520

gccgccggaa aagaactgct ggagcggttg caacaggtag cgtcagaaac aggcaccacc   5580

ttgtacatga ttttgcttgc cgcctacaat gtgctgctgt ccaagtatac cggccaggaa   5640

gacatcatcg tcgggacgcc tgtcgctgga cgttcccatg cggacgtgga aaacatcatg   5700

ggcatattcg tgaacacatt ggcgctgcgc aaccagcctg ccagcagcaa aacgatgtta   5760

gaaaataata ttacacaatg tgactcaatc aatgatgttt atcttaaaga agaagcaata   5820

acattgatgg atatgcttga gagtcaactt aagcaccagg cagatggata tgttgttatt   5880

gatcaagaag aatctctcag ttacgctgat ttctatttga gggtgaaaga gatagggtat   5940

tgtctgtcag aaattagctc aaagaattcg gtgggtattg ggcttttttg tgatccttct   6000

atagatttaa tttgtggtgc atggggtatt ttgtcagcgg ataaagctta tttgccgtta   6060

tcgcctgact atccaactga acgcctcaaa tatatgatag aagattctgg tattgatgtg   6120

atttttacgc aatcgcactt aaaagcacag ctacaggaca ttgcaccaaa atcagtatta   6180

attatgacac cagaagatgt cgctctgacg ataaaaacac gaacaataga agatattctg   6240

ggcacagttc aagttcctaa acccactagt ctggcttata ttatttatac ctctggtagc   6300

acgggtaagc caaagggagt gatgattgaa catcacagta ttgtaaatca aatgagattt   6360

cttgcaaaag cgttcaaatt aggatgtcat tcccggattt tacagaaaac accaatgagt   6420

tttgatgcgg ctcaatggga aattctagcg cctgcaattg gtggtcaagt gattatgggt   6480

cctttaggtt gctatcgcga tccggatgca attattaaaa ccattcttca gcatcaagta   6540

acgactttgc aatgtgttcc tactttgcta caagcgttac tggataatcc taattttttg   6600

gattgcttat cattgactca agtattcagt gggggagaag cgctgacaac caaattagcc   6660

acgcaatttt tgaatagttt tactcactgt gaattaatca atttatatgg cccgacagaa   6720

tgtacgatta attcatcatt tttccgggtg acaaatgaga ctttgccgaa ttatcaaacc   6780

tctatttcga ttggtgcacc tgtagataat accgaatact acgttcttga tgatgataga   6840

ttacctgtgg cggttggcga aattggcgag ctttatattt cgggtgctca attagcacgt   6900

ggttatttgc ataaaccaga aatgacaaaa gataaattta tttgtaatca ccttgtatca   6960

ggaactcaac atcaatggtt atatcgaacg ggagatctgg taaccagagg ggctgatggt   7020

aatacttatt ttgttggtcg ggttgatagc caggtcaaat tacgaggtta ccgtattgag   7080

cttgatgaaa tacgccatgc gattgaagaa catagctgga taaagacggc ggcaatgtta   7140

attaagaagg atgccagaac gggtttccaa aatctcatcg cgtgtgtgga attagatgag   7200

aaagaagctg cattgatgga tcaaggtaat agtagctcac atcacaaatc aaaagccgat   7260

aaactacagg tgaaagccca actttctaat tctggttgtc gaagtgaaga gttatgtgaa   7320

aatcgcccta cattcttact tccttatcaa gaaggggaga taaaacagag agaatatgca   7380

tttggacgca agacatatcg ctattttgag ggaacagaaa taacggtaga gaaattaaaa   7440

aaattgctga cagccactca atcgaatgaa attagctctt tgccactgag tcatctaacc   7500

ctgaatgatt tcggttatgc attgcgttat tttggtcagt ttaccagcca tcaacgttta   7560

ttgcccaaat atgcctatgc ttcaccgggt gctctctatg cgacacaaat gtattttgaa   7620

ttgcataatg ttctcggttt ggatgcgggg atttactatt atcatccagt gacacataag   7680

ttaataaaaa tttcaacatt gagtcgtcgg caaatgccaa cgataaaagt gcattttatt   7740

ggcaagcatg aagccattga gcccgtttat aagaacaata tacaagaagt tctggaaatg   7800

gaagcgggcc atatgatggg tctttttgat gacgtattac cggaaattgg cttgagtatt   7860

ggtaaaagtg aatatcaaga tgaatgtcca gattggtatg atggtgatat tcaggattat   7920

tatcttggtg catttgaaat atgtagctat gaacatggat tgccgccatt tgagactgat   7980

atttatttac aaacacatgc ccataaaata cctgagatgc cgtgtggttt atatcacttt   8040

tctaacgggg aatttgtacg aataagtgat gatattgtcc gaaaaaagga tgttattgcg   8100

attaatcagc aagtttatga tcgctccagt tttggcgtgt caattattcc acgctgtgtc   8160

cctgaatggc attattatat aacactgggt cgtcggttac atgcgttaca aagtaatcca   8220

ttgtatattg gattaatgtc atctggttac agttcgaaga gcaataacga tttaccttcg   8280

gcgaaaagga tgcgatctat tctcaatgca cttgatagac ctatggcggc attttatttc   8340

tgcataggtg ggggtattag ccaagcgcaa tatatgtgtg aaggcatgaa agaagatgtt   8400

gttcatatga aagggccagt tgaaatcatt aaagatgatc ttcaacaaca actccctcaa   8460

tatatgattc caaataaggt attagttttc gataaattac ctttgacggc caatggaaaa   8520

gtggattatc aatctttatc agaatctaaa gccgtggaga atgtttcaac acagcgtcta   8580

ttggtgccat tacatacaga tactgaaata aggcttggaa aaatttggat ggaagtactg   8640

aaatgggatt cagtatctgc cctcgatgat tttttcgaaa gtgggggtaa ttctttgatg   8700

gccgttgcaa tggttaataa gatcaatgcg gcctttaata ttcgttttcc gttacagata   8760

ctttttcaat ctcctaatat agcagaattg gctaagtgga ttgaacagac agactctaaa   8820

acaatatcaa gattaatttt attgaatcag gcaagcaaag accccattta ctgttggccg   8880

ggtttgggcg gatatcctat gagtttgaga ttgcttgcta ataaagtcgt tcctgatcgg   8940

gcattttatg gaatacaggc atatgggata aacgagagtg aaataccgtt ttcttctatc   9000

cagagaatgg cagaagagga tattaaagag ataaagaaaa tacagccaga agggccatat   9060

atattgtggg gatattcatt tggtgcccga gtagcatttg aagttgcata ccagcttgaa   9120

caagcgggag aagaagttaa cgcattgaat ttattggctc cgggatctcc tcatcttgat   9180

atgaagcaag cggaatatat ggataaaggc gctgaattta ctaatccggc ttttgttaaa   9240

atactttttt ctgtattttc tcgttcaatc aacagcccaa tggttaaaac ttgcttagaa   9300

caagtaaata gtgaaacgac atttattaac tttatatgta gtcgttttaa aaacttggaa   9360

ccatcattag taaaacgtat cgttaggatt gtgactttga cttatgattt caagtacagt   9420

attgatgagc tttatcacag acacctaaag gcacctataa ctattttcaa ggcgaataga   9480

gataatgatt catttatcga ggaatcggat gtgatttcat caatgtcgcc taaaataatt   9540

gaattaatat cggatcacta tcaactgttg gaaagtgaag gtgttgctga gattgagaaa   9600

ataatctaa                                                           9609


<210>  25
<211>  1284
<212>  PRT
<213>  Photorhabdus luminescens

<400>  25

Met Leu Glu Asn Asn Ile Thr Gln Cys Asp Ser Ile Asn Asp Val Tyr 
1               5                   10                  15      


Leu Lys Glu Glu Ala Ile Thr Leu Met Asp Met Leu Glu Ser Gln Leu 
            20                  25                  30          


Lys His Gln Ala Asp Gly Tyr Val Val Ile Asp Gln Glu Glu Ser Leu 
        35                  40                  45              


Ser Tyr Ala Asp Phe Tyr Leu Arg Val Lys Glu Ile Gly Tyr Cys Leu 
    50                  55                  60                  


Ser Glu Ile Ser Ser Lys Asn Ser Val Gly Ile Gly Leu Phe Cys Asp 
65                  70                  75                  80  


Pro Ser Ile Asp Leu Ile Cys Gly Ala Trp Gly Ile Leu Ser Ala Asp 
                85                  90                  95      


Lys Ala Tyr Leu Pro Leu Ser Pro Asp Tyr Pro Thr Glu Arg Leu Lys 
            100                 105                 110         


Tyr Met Ile Glu Asp Ser Gly Ile Asp Val Ile Phe Thr Gln Ser His 
        115                 120                 125             


Leu Lys Ala Gln Leu Gln Asp Ile Ala Pro Lys Ser Val Leu Ile Met 
    130                 135                 140                 


Thr Pro Glu Asp Val Ala Leu Thr Ile Lys Thr Arg Thr Ile Glu Asp 
145                 150                 155                 160 


Ile Leu Gly Thr Val Gln Val Pro Lys Pro Thr Ser Leu Ala Tyr Ile 
                165                 170                 175     


Ile Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly Val Met Ile Glu 
            180                 185                 190         


His His Ser Ile Val Asn Gln Met Arg Phe Leu Ala Lys Ala Phe Lys 
        195                 200                 205             


Leu Gly Cys His Ser Arg Ile Leu Gln Lys Thr Pro Met Ser Phe Asp 
    210                 215                 220                 


Ala Ala Gln Trp Glu Ile Leu Ala Pro Ala Ile Gly Gly Gln Val Ile 
225                 230                 235                 240 


Met Gly Pro Leu Gly Cys Tyr Arg Asp Pro Asp Ala Ile Ile Lys Thr 
                245                 250                 255     


Ile Leu Gln His Gln Val Thr Thr Leu Gln Cys Val Pro Thr Leu Leu 
            260                 265                 270         


Gln Ala Leu Leu Asp Asn Pro Asn Phe Leu Asp Cys Leu Ser Leu Thr 
        275                 280                 285             


Gln Val Phe Ser Gly Gly Glu Ala Leu Thr Thr Lys Leu Ala Thr Gln 
    290                 295                 300                 


Phe Leu Asn Ser Phe Thr His Cys Glu Leu Ile Asn Leu Tyr Gly Pro 
305                 310                 315                 320 


Thr Glu Cys Thr Ile Asn Ser Ser Phe Phe Arg Val Thr Asn Glu Thr 
                325                 330                 335     


Leu Pro Asn Tyr Gln Thr Ser Ile Ser Ile Gly Ala Pro Val Asp Asn 
            340                 345                 350         


Thr Glu Tyr Tyr Val Leu Asp Asp Asp Arg Leu Pro Val Ala Val Gly 
        355                 360                 365             


Glu Ile Gly Glu Leu Tyr Ile Ser Gly Ala Gln Leu Ala Arg Gly Tyr 
    370                 375                 380                 


Leu His Lys Pro Glu Met Thr Lys Asp Lys Phe Ile Cys Asn His Leu 
385                 390                 395                 400 


Val Ser Gly Thr Gln His Gln Trp Leu Tyr Arg Thr Gly Asp Leu Val 
                405                 410                 415     


Thr Arg Gly Ala Asp Gly Asn Thr Tyr Phe Val Gly Arg Val Asp Ser 
            420                 425                 430         


Gln Val Lys Leu Arg Gly Tyr Arg Ile Glu Leu Asp Glu Ile Arg His 
        435                 440                 445             


Ala Ile Glu Glu His Ser Trp Ile Lys Thr Ala Ala Met Leu Ile Lys 
    450                 455                 460                 


Lys Asp Ala Arg Thr Gly Phe Gln Asn Leu Ile Ala Cys Val Glu Leu 
465                 470                 475                 480 


Asp Glu Lys Glu Ala Ala Leu Met Asp Gln Gly Asn Ser Ser Ser His 
                485                 490                 495     


His Lys Ser Lys Ala Asp Lys Leu Gln Val Lys Ala Gln Leu Ser Asn 
            500                 505                 510         


Ser Gly Cys Arg Ser Glu Glu Leu Cys Glu Asn Arg Pro Thr Phe Leu 
        515                 520                 525             


Leu Pro Tyr Gln Glu Gly Glu Ile Lys Gln Arg Glu Tyr Ala Phe Gly 
    530                 535                 540                 


Arg Lys Thr Tyr Arg Tyr Phe Glu Gly Thr Glu Ile Thr Val Glu Lys 
545                 550                 555                 560 


Leu Lys Lys Leu Leu Thr Ala Thr Gln Ser Asn Glu Ile Ser Ser Leu 
                565                 570                 575     


Pro Leu Ser His Leu Thr Leu Asn Asp Phe Gly Tyr Ala Leu Arg Tyr 
            580                 585                 590         


Phe Gly Gln Phe Thr Ser His Gln Arg Leu Leu Pro Lys Tyr Ala Tyr 
        595                 600                 605             


Ala Ser Pro Gly Ala Leu Tyr Ala Thr Gln Met Tyr Phe Glu Leu His 
    610                 615                 620                 


Asn Val Leu Gly Leu Asp Ala Gly Ile Tyr Tyr Tyr His Pro Val Thr 
625                 630                 635                 640 


His Lys Leu Ile Lys Ile Ser Thr Leu Ser Arg Arg Gln Met Pro Thr 
                645                 650                 655     


Ile Lys Val His Phe Ile Gly Lys His Glu Ala Ile Glu Pro Val Tyr 
            660                 665                 670         


Lys Asn Asn Ile Gln Glu Val Leu Glu Met Glu Ala Gly His Met Met 
        675                 680                 685             


Gly Leu Phe Asp Asp Val Leu Pro Glu Ile Gly Leu Ser Ile Gly Lys 
    690                 695                 700                 


Ser Glu Tyr Gln Asp Glu Cys Pro Asp Trp Tyr Asp Gly Asp Ile Gln 
705                 710                 715                 720 


Asp Tyr Tyr Leu Gly Ala Phe Glu Ile Cys Ser Tyr Glu His Gly Leu 
                725                 730                 735     


Pro Pro Phe Glu Thr Asp Ile Tyr Leu Gln Thr His Ala His Lys Ile 
            740                 745                 750         


Pro Glu Met Pro Cys Gly Leu Tyr His Phe Ser Asn Gly Glu Phe Val 
        755                 760                 765             


Arg Ile Ser Asp Asp Ile Val Arg Lys Lys Asp Val Ile Ala Ile Asn 
    770                 775                 780                 


Gln Gln Val Tyr Asp Arg Ser Ser Phe Gly Val Ser Ile Ile Pro Arg 
785                 790                 795                 800 


Cys Val Pro Glu Trp His Tyr Tyr Ile Thr Leu Gly Arg Arg Leu His 
                805                 810                 815     


Ala Leu Gln Ser Asn Pro Leu Tyr Ile Gly Leu Met Ser Ser Gly Tyr 
            820                 825                 830         


Ser Ser Lys Ser Asn Asn Asp Leu Pro Ser Ala Lys Arg Met Arg Ser 
        835                 840                 845             


Ile Leu Asn Ala Leu Asp Arg Pro Met Ala Ala Phe Tyr Phe Cys Ile 
    850                 855                 860                 


Gly Gly Gly Ile Ser Gln Ala Gln Tyr Met Cys Glu Gly Met Lys Glu 
865                 870                 875                 880 


Asp Val Val His Met Lys Gly Pro Val Glu Ile Ile Lys Asp Asp Leu 
                885                 890                 895     


Gln Gln Gln Leu Pro Gln Tyr Met Ile Pro Asn Lys Val Leu Val Phe 
            900                 905                 910         


Asp Lys Leu Pro Leu Thr Ala Asn Gly Lys Val Asp Tyr Gln Ser Leu 
        915                 920                 925             


Ser Glu Ser Lys Ala Val Glu Asn Val Ser Thr Gln Arg Leu Leu Val 
    930                 935                 940                 


Pro Leu His Thr Asp Thr Glu Ile Arg Leu Gly Lys Ile Trp Met Glu 
945                 950                 955                 960 


Val Leu Lys Trp Asp Ser Val Ser Ala Leu Asp Asp Phe Phe Glu Ser 
                965                 970                 975     


Gly Gly Asn Ser Leu Met Ala Val Ala Met Val Asn Lys Ile Asn Ala 
            980                 985                 990         


Ala Phe Asn Ile Arg Phe Pro Leu  Gln Ile Leu Phe Gln  Ser Pro Asn 
        995                 1000                 1005             


Ile Ala  Glu Leu Ala Lys Trp  Ile Glu Gln Thr Asp  Ser Lys Thr 
    1010                 1015                 1020             


Ile Ser  Arg Leu Ile Leu Leu  Asn Gln Ala Ser Lys  Asp Pro Ile 
    1025                 1030                 1035             


Tyr Cys  Trp Pro Gly Leu Gly  Gly Tyr Pro Met Ser  Leu Arg Leu 
    1040                 1045                 1050             


Leu Ala  Asn Lys Val Val Pro  Asp Arg Ala Phe Tyr  Gly Ile Gln 
    1055                 1060                 1065             


Ala Tyr  Gly Ile Asn Glu Ser  Glu Ile Pro Phe Ser  Ser Ile Gln 
    1070                 1075                 1080             


Arg Met  Ala Glu Glu Asp Ile  Lys Glu Ile Lys Lys  Ile Gln Pro 
    1085                 1090                 1095             


Glu Gly  Pro Tyr Ile Leu Trp  Gly Tyr Ser Phe Gly  Ala Arg Val 
    1100                 1105                 1110             


Ala Phe  Glu Val Ala Tyr Gln  Leu Glu Gln Ala Gly  Glu Glu Val 
    1115                 1120                 1125             


Asn Ala  Leu Asn Leu Leu Ala  Pro Gly Ser Pro His  Leu Asp Met 
    1130                 1135                 1140             


Lys Gln  Ala Glu Tyr Met Asp  Lys Gly Ala Glu Phe  Thr Asn Pro 
    1145                 1150                 1155             


Ala Phe  Val Lys Ile Leu Phe  Ser Val Phe Ser Arg  Ser Ile Asn 
    1160                 1165                 1170             


Ser Pro  Met Val Lys Thr Cys  Leu Glu Gln Val Asn  Ser Glu Thr 
    1175                 1180                 1185             


Thr Phe  Ile Asn Phe Ile Cys  Ser Arg Phe Lys Asn  Leu Glu Pro 
    1190                 1195                 1200             


Ser Leu  Val Lys Arg Ile Val  Arg Ile Val Thr Leu  Thr Tyr Asp 
    1205                 1210                 1215             


Phe Lys  Tyr Ser Ile Asp Glu  Leu Tyr His Arg His  Leu Lys Ala 
    1220                 1225                 1230             


Pro Ile  Thr Ile Phe Lys Ala  Asn Arg Asp Asn Asp  Ser Phe Ile 
    1235                 1240                 1245             


Glu Glu  Ser Asp Val Ile Ser  Ser Met Ser Pro Lys  Ile Ile Glu 
    1250                 1255                 1260             


Leu Ile  Ser Asp His Tyr Gln  Leu Leu Glu Ser Glu  Gly Val Ala 
    1265                 1270                 1275             


Glu Ile  Glu Lys Ile Ile 
    1280                 


<210>  26
<211>  4776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minimal construct C(of TycC2)-Ind

<400>  26
tcggaaaaaa ccgagtacac cgcgattcaa cccgtggcag cgcaggagtt ttacccggtt     60

tcatctgcgc aaaaaagaat gtatatcctg caacagttcg aaggcaacgg aatcagctac    120

aacatttcgg gtgcgattct cctggaagga aagctggact acgcccggtt tgccagcgct    180

gtgcaacagc tggcagagcg ccacgaagct ttgcgcacct cgttccaccg gatcgacggc    240

gagcctgtgc aaaaagtgca cgaggaagta gaagtgccgc ttttcatgct ggaggctccc    300

gaagaccagg cggagaaaat catgcgcgag tttgtccgtc cgtttgatct cggggtcgct    360

ccgctgatgc gaacaggttt gctcaagctg ggcaaagacc gccatttgtt tttgctcgac    420

atgcaccata tcatctcgga cggcgtttct tcgcaaattt tgctgcgtga atttgccgag    480

ttgtaccagg gagcagactt gcagccgctt tcgctgcaat acaaagattt cgctgcttgg    540

caaaatgagc tgtttcagac ggaggcatac aagaagcagg agcagcactg gctgaacacg    600

tttgctgatg aaattccgct cttgaacctg ccgactgact atccgcgccc tagcgtgcaa    660

agctttgcag gcgatctcgt cctttttgcc gccggaaaag aactgctgga gcggttgcaa    720

caggtagcgt cagaaacagg caccaccttg tacatgattt tgcttgccgc ctacaatgtg    780

ctgctgtcca agtataccgg ccaggaagac atcatcgtcg ggacgcctgt cgctggacgt    840

tcccatgcgg acgtggaaaa catcatgggc atattcgtga acacattggc gctgcgcaac    900

cagcctgcca gcagcaaaac gatgttagaa aataatatta cacaatgtga ctcaatcaat    960

gatgtttatc ttaaagaaga agcaataaca ttgatggata tgcttgagag tcaacttaag   1020

caccaggcag atggatatgt tgttattgat caagaagaat ctctcagtta cgctgatttc   1080

tatttgaggg tgaaagagat agggtattgt ctgtcagaaa ttagctcaaa gagttcggtg   1140

ggtattgggc ttttttgtga tccttctata gatttaattt gtggtgcatg gggtattttg   1200

tcagcggata aagcttattt gccgttatcg cctgactatc caactgaacg cctcaaatat   1260

atgatagaag attctggtat tgatgtgatt tttacgcaat cgcacttaaa agcacagcta   1320

caggacattg caccaaaatc agtattaatt atgacaccag aagatgtcgc tctgacgata   1380

aaaacacgaa caatagaaga tattctgggc acagttcaag ttcctaaacc cacgagtctg   1440

gcttatatta tttatacctc tggtagcacg ggtaagccaa agggagtgat gattgaacat   1500

cacagtattg taaatcaaat gagatttctt gcaaaagcgt tcaaattagg atgtcattcc   1560

cggattttac agaaaacacc aatgagtttt gatgcggctc aatgggaaat tctagcgcct   1620

gcaattggtg gtcaagtgat tatgggtcct ttaggttgct atcgcgatcc ggatgcaatt   1680

attaaaacca ttcttcagca tcaagtaacg actttgcaat gtgttcctac tttgctacaa   1740

gcgttactgg ataatcctaa ttttttggat tgcttatcat tgactcaagt attcagtggg   1800

ggagaagcgc tgacaaccaa attagccacg caatttttga atagttttac tcactgtgaa   1860

ttaatcaatt tatatggccc gacagaatgt acgattaatt catcattttt ccgggtgaca   1920

aatgagactt tgccgaatta tcaaacctct atttcgattg gtgcacctgt agataatacc   1980

gaatactacg ttcttgatga tgatagatta cctgtggcgg ttggcgaaat tggcgagctt   2040

tatatttcgg gtgctcaatt agcacgtggt tatttgcata aaccagaaat gacaaaagat   2100

aaatttattt gtaatcacct tgtatcagga actcaacatc aatggttata tcgaacggga   2160

gatctggtaa ccagaggggc tgatggtaat acttattttg ttggtcgggt tgatagccag   2220

gtcaaattac gaggttaccg tattgagctt gatgaaatac gccatgcgat tgaagaacat   2280

agctggataa agacggcggc aatgttaatt aagaaggatg ccagaacggg tttccaaaat   2340

ctcatcgcgt gtgtggaatt agatgagaaa gaagctgcat tgatggatca aggtaatagt   2400

agctcacatc acaaatcaaa agccgataaa ctacaggtga aagcccaact ttctaattct   2460

ggttgtcgaa gtgaagagtt atgtgaaaat cgccctacat tcttacttcc ttatcaagaa   2520

ggggagataa aacagagaga atatgcattt ggacgcaaga catatcgcta ttttgaggga   2580

acagaaataa cggtagagaa attaaaaaaa ttgctgacag ccactcaatc gaatgaaatt   2640

agctctttgc cactgagtca tctaaccctg aatgatttcg gttatgcatt gcgttatttt   2700

ggtcagttta ccagccatca acgtttattg cccaaatatg cctatgcttc accgggtgct   2760

ctctatgcga cacaaatgta ttttgaattg cataatgttc tcggtttgga tgcggggatt   2820

tactattatc atccagtgac acataagtta ataaaaattt caacattgag tcgtcggcaa   2880

atgccaacga taaaagtgca ttttattggc aagcatgaag ccattgagcc cgtttataag   2940

aacaatatac aagaagttct ggaaatggaa gcgggccata tgatgggtct ttttgatgac   3000

gtattaccgg aaattggctt gagtattggt aaaagtgaat atcaagatga atgtccagat   3060

tggtatgatg gtgatattca ggattattat cttggtgcat ttgaaatatg tagctatgaa   3120

catggattgc cgccatttga gactgatatt tatttacaaa cacatgccca taaaatacct   3180

gagatgccgt gtggtttata tcacttttct aacggggaat ttgtacgaat aagtgatgat   3240

attgtccgaa aaaaggatgt tattgcgatt aatcagcaag tttatgatcg ctccagtttt   3300

ggcgtgtcaa ttattccacg ctgtgtccct gaatggcatt attatataac actgggtcgt   3360

cggttacatg cgttacaaag taatccattg tatattggat taatgtcatc tggttacagt   3420

tcgaagagca ataacgattt accttcggcg aaaaggatgc gatctattct caatgcactt   3480

gatagaccta tggcggcatt ttatttctgc ataggtgggg gtattagcca agcgcaatat   3540

atgtgtgaag gcatgaaaga agatgttgtt catatgaaag ggccagttga aatcattaaa   3600

gatgatcttc aacaacaact ccctcaatat atgattccaa ataaggtatt agttttcgat   3660

aaattacctt tgacggccaa tggaaaagtg gattatcaat ctttatcaga atctaaagcc   3720

gtggagaatg tttcaacaca gcgtctattg gtgccattac atacagatac tgaaataagg   3780

cttggaaaaa tttggatgga agtactgaaa tgggattcag tatctgccct cgatgatttt   3840

ttcgaaagtg ggggtaattc tttgatggcc gttgcaatgg ttaataagat caatgcggcc   3900

tttaatattc gttttccgtt acagatactt tttcaatctc ctaatatagc agaattggct   3960

aagtggattg aacagacaga ctctaaaaca atatcaagat taattttatt gaatcaggca   4020

agcaaagacc ccatttactg ttggccgggt ttgggcggat atcctatgag tttgagattg   4080

cttgctaata aagtcgttcc tgatcgggca ttttatggaa tacaggcata tgggataaac   4140

gagagtgaaa taccgttttc ttctatccag agaatggcag aagaggatat taaagagata   4200

aagaaaatac agccagaagg gccatatata ttgtggggat attcatttgg tgcccgagta   4260

gcatttgaag ttgcatacca gcttgaacaa gcgggagaag aagttaacgc attgaattta   4320

ttggctccgg gatctcctca tcttgatatg aagcaagcgg aatatatgga taaaggcgct   4380

gaatttacta atccggcttt tgttaaaata cttttttctg tattttctcg ttcaatcaac   4440

agcccaatgg ttaaaacttg cttagaacaa gtaaatagtg aaacgacatt tattaacttt   4500

atatgtagtc gttttaaaaa cttggaacca tcattagtaa aacgtatcgt taggattgtg   4560

actttgactt atgatttcaa gtacagtatt gatgagcttt atcacagaca cctaaaggca   4620

cctataacta ttttcaaggc gaatagagat aatgattcat ttatcgagga atcggatgtg   4680

atttcatcaa tgtcgcctaa aataattgaa ttaatatcgg atcactatca actgttggaa   4740

agtgaaggtg ttgctgagat tgagaaaata atctaa                             4776


<210>  27
<211>  2327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase of a fusion peptide consisting of Asparagine and 
       Indigoidine

<400>  27

Met Gln Thr Asn Lys Gln Gln Thr Phe Ser Glu Leu Leu Gln Thr Val 
1               5                   10                  15      


Gln Lys Gln Ala Leu Ala Ser Ala Thr Tyr Asp Phe Ala Pro Leu Tyr 
            20                  25                  30          


Glu Ile Gln Ser Thr Thr Val Leu Lys Gln Glu Leu Ile Asp His Leu 
        35                  40                  45              


Val Thr Phe Glu Asn Tyr Pro Asp His Ser Met Lys His Leu Glu Glu 
    50                  55                  60                  


Ser Leu Gly Phe Gln Phe Thr Val Glu Ser Gly Asp Glu Gln Thr Ser 
65                  70                  75                  80  


Tyr Asp Leu Asn Val Val Val Ala Leu Ala Pro Ser Asn Glu Leu Tyr 
                85                  90                  95      


Val Lys Leu Ser Tyr Asn Ala Ala Val Tyr Glu Ser Ser Phe Val Asn 
            100                 105                 110         


Arg Ile Glu Gly His Leu Arg Thr Val Ile Asp Gln Val Ile Gly Asn 
        115                 120                 125             


Pro His Val His Leu His Glu Ile Gly Ile Ile Thr Glu Glu Glu Lys 
    130                 135                 140                 


Gln Gln Leu Leu Val Ala Tyr Asn Asp Thr Ala Ala Glu Tyr Pro Arg 
145                 150                 155                 160 


Asp Lys Thr Ile Phe Glu Leu Ile Ala Glu Gln Ala Ser Arg Thr Pro 
                165                 170                 175     


Ala Lys Ala Ala Val Val Cys Gly Glu Asp Thr Leu Thr Tyr Gln Glu 
            180                 185                 190         


Leu Met Glu Arg Ser Ala Gln Leu Ala Asn Ala Leu Arg Glu Lys Gly 
        195                 200                 205             


Ile Ala Ser Gly Ser Ile Val Ser Ile Met Ala Glu His Ser Leu Glu 
    210                 215                 220                 


Leu Ile Val Ala Ile Met Ala Val Leu Arg Ser Gly Ala Ala Tyr Leu 
225                 230                 235                 240 


Pro Ile Asp Pro Glu Tyr Pro Gln Asp Arg Ile Gln Tyr Leu Leu Asp 
                245                 250                 255     


Asp Ser Gln Thr Thr Leu Leu Leu Thr Gln Ser His Leu Gln Pro Asn 
            260                 265                 270         


Ile Arg Phe Ala Gly Ser Val Leu Tyr Leu Asp Asp Arg Ser Leu Tyr 
        275                 280                 285             


Glu Gly Gly Ser Thr Ser Phe Ala Pro Glu Ser Lys Pro Asp Asp Leu 
    290                 295                 300                 


Ala Tyr Met Ile Tyr Thr Ser Gly Ser Thr Gly Asn Pro Lys Gly Ala 
305                 310                 315                 320 


Met Ile Thr His Gln Gly Leu Val Asn Tyr Ile Trp Trp Ala Asn Lys 
                325                 330                 335     


Val Tyr Val Gln Gly Glu Ala Val Asp Phe Pro Leu Tyr Ser Ser Ile 
            340                 345                 350         


Ser Phe Asp Leu Thr Val Thr Ser Ile Phe Thr Pro Leu Leu Ser Gly 
        355                 360                 365             


Asn Thr Ile His Val Tyr Arg Gly Ala Asp Lys Val Gln Val Ile Leu 
    370                 375                 380                 


Asp Ile Ile Lys Asp Asn Lys Val Gly Ile Ile Lys Leu Thr Pro Thr 
385                 390                 395                 400 


His Leu Lys Leu Ile Glu His Ile Asp Gly Lys Ala Ser Ser Ile Arg 
                405                 410                 415     


Arg Phe Ile Val Gly Gly Glu Asn Leu Pro Thr Lys Leu Ala Lys Gln 
            420                 425                 430         


Ile Tyr Asp His Phe Gly Glu Asn Val Gln Ile Phe Asn Glu Tyr Gly 
        435                 440                 445             


Pro Thr Glu Thr Val Val Gly Cys Met Ile Tyr Leu Tyr Asp Pro Gln 
    450                 455                 460                 


Thr Thr Thr Gln Glu Ser Val Pro Ile Gly Val Pro Ala Asp Asn Val 
465                 470                 475                 480 


Gln Leu Tyr Leu Leu Asp Ala Ser Met Gln Pro Val Pro Val Gly Ser 
                485                 490                 495     


Leu Gly Glu Met Tyr Ile Ala Gly Asp Gly Val Ala Lys Gly Tyr Phe 
            500                 505                 510         


Asn Arg Pro Glu Leu Thr Lys Glu Lys Phe Ile Asp Asn Pro Phe Arg 
        515                 520                 525             


Pro Gly Thr Lys Met Tyr Arg Thr Gly Asp Leu Ala Lys Trp Leu Pro 
    530                 535                 540                 


Asp Gly Asn Met Glu Tyr Ala Gly Arg Met Asp Tyr Gln Val Lys Ile 
545                 550                 555                 560 


Arg Gly His Arg Ile Glu Met Gly Glu Ile Glu Thr Arg Leu Thr Gln 
                565                 570                 575     


His Glu Ala Val Lys Glu Ala Val Val Ile Val Glu Lys Asp Glu Ser 
            580                 585                 590         


Gly Gln Asn Val Leu Tyr Ala Tyr Leu Val Ser Glu Arg Glu Leu Thr 
        595                 600                 605             


Val Ala Glu Leu Arg Glu Phe Leu Gly Arg Thr Leu Pro Ser Tyr Met 
    610                 615                 620                 


Ile Pro Ser Phe Phe Ile Arg Leu Ala Glu Ile Pro Leu Thr Ala Asn 
625                 630                 635                 640 


Gly Lys Val Glu Arg Lys Lys Leu Pro Lys Pro Ala Gly Ala Val Val 
                645                 650                 655     


Thr Gly Thr Ala Tyr Ala Ala Pro Gln Asn Glu Ile Glu Ala Lys Leu 
            660                 665                 670         


Ala Glu Ile Trp Gln Gln Val Leu Gly Ile Ser Gln Val Gly Ile His 
        675                 680                 685             


Asp Asp Phe Phe Asp Leu Gly Gly His Ser Leu Lys Ala Met Thr Val 
    690                 695                 700                 


Val Phe Gln Val Ser Lys Ala Leu Glu Val Glu Leu Pro Val Lys Ala 
705                 710                 715                 720 


Leu Phe Glu His Pro Thr Val Ala Glu Leu Ala Arg Phe Leu Ser Arg 
                725                 730                 735     


Ser Glu Lys Thr Glu Tyr Thr Ala Ile Gln Pro Val Ala Ala Gln Glu 
            740                 745                 750         


Phe Tyr Pro Val Ser Ser Ala Gln Lys Arg Met Tyr Ile Leu Gln Gln 
        755                 760                 765             


Phe Glu Gly Asn Gly Ile Ser Tyr Asn Ile Ser Gly Ala Ile Leu Leu 
    770                 775                 780                 


Glu Gly Lys Leu Asp Tyr Ala Arg Phe Ala Ser Ala Val Gln Gln Leu 
785                 790                 795                 800 


Ala Glu Arg His Glu Ala Leu Arg Thr Ser Phe His Arg Ile Asp Gly 
                805                 810                 815     


Glu Pro Val Gln Lys Val His Glu Glu Val Glu Val Pro Leu Phe Met 
            820                 825                 830         


Leu Glu Ala Pro Glu Asp Gln Ala Glu Lys Ile Met Arg Glu Phe Val 
        835                 840                 845             


Arg Pro Phe Asp Leu Gly Val Ala Pro Leu Met Arg Thr Gly Leu Leu 
    850                 855                 860                 


Lys Leu Gly Lys Asp Arg His Leu Phe Leu Leu Asp Met His His Ile 
865                 870                 875                 880 


Ile Ser Asp Gly Val Ser Ser Gln Ile Leu Leu Arg Glu Phe Ala Glu 
                885                 890                 895     


Leu Tyr Gln Gly Ala Asp Leu Gln Pro Leu Ser Leu Gln Tyr Lys Asp 
            900                 905                 910         


Phe Ala Ala Trp Gln Asn Glu Leu Phe Gln Thr Glu Ala Tyr Lys Lys 
        915                 920                 925             


Gln Glu Gln His Trp Leu Asn Thr Phe Ala Asp Glu Ile Pro Leu Leu 
    930                 935                 940                 


Asn Leu Pro Thr Asp Tyr Pro Arg Pro Ser Val Gln Ser Phe Ala Gly 
945                 950                 955                 960 


Asp Leu Val Leu Phe Ala Ala Gly Lys Glu Leu Leu Glu Arg Leu Gln 
                965                 970                 975     


Gln Val Ala Ser Glu Thr Gly Thr Thr Leu Tyr Met Ile Leu Leu Ala 
            980                 985                 990         


Ala Tyr Asn Val Leu Leu Ser Lys  Tyr Thr Gly Gln Glu  Asp Ile Ile 
        995                 1000                 1005             


Val Gly  Thr Pro Val Ala Gly  Arg Ser His Ala Asp  Val Glu Asn 
    1010                 1015                 1020             


Ile Met  Gly Ile Phe Val Asn  Thr Leu Ala Leu Arg  Asn Gln Pro 
    1025                 1030                 1035             


Ala Ser  Ser Lys Thr Met Leu  Glu Asn Asn Ile Thr  Gln Cys Asp 
    1040                 1045                 1050             


Ser Ile  Asn Asp Val Tyr Leu  Lys Glu Glu Ala Ile  Thr Leu Met 
    1055                 1060                 1065             


Asp Met  Leu Glu Ser Gln Leu  Lys His Gln Ala Asp  Gly Tyr Val 
    1070                 1075                 1080             


Val Ile  Asp Gln Glu Glu Ser  Leu Ser Tyr Ala Asp  Phe Tyr Leu 
    1085                 1090                 1095             


Arg Val  Lys Glu Ile Gly Tyr  Cys Leu Ser Glu Ile  Ser Ser Lys 
    1100                 1105                 1110             


Asn Ser  Val Gly Ile Gly Leu  Phe Cys Asp Pro Ser  Ile Asp Leu 
    1115                 1120                 1125             


Ile Cys  Gly Ala Trp Gly Ile  Leu Ser Ala Asp Lys  Ala Tyr Leu 
    1130                 1135                 1140             


Pro Leu  Ser Pro Asp Tyr Pro  Thr Glu Arg Leu Lys  Tyr Met Ile 
    1145                 1150                 1155             


Glu Asp  Ser Gly Ile Asp Val  Ile Phe Thr Gln Ser  His Leu Lys 
    1160                 1165                 1170             


Ala Gln  Leu Gln Asp Ile Ala  Pro Lys Ser Val Leu  Ile Met Thr 
    1175                 1180                 1185             


Pro Glu  Asp Val Ala Leu Thr  Ile Lys Thr Arg Thr  Ile Glu Asp 
    1190                 1195                 1200             


Ile Leu  Gly Thr Val Gln Val  Pro Lys Pro Thr Ser  Leu Ala Tyr 
    1205                 1210                 1215             


Ile Ile  Tyr Thr Ser Gly Ser  Thr Gly Lys Pro Lys  Gly Val Met 
    1220                 1225                 1230             


Ile Glu  His His Ser Ile Val  Asn Gln Met Arg Phe  Leu Ala Lys 
    1235                 1240                 1245             


Ala Phe  Lys Leu Gly Cys His  Ser Arg Ile Leu Gln  Lys Thr Pro 
    1250                 1255                 1260             


Met Ser  Phe Asp Ala Ala Gln  Trp Glu Ile Leu Ala  Pro Ala Ile 
    1265                 1270                 1275             


Gly Gly  Gln Val Ile Met Gly  Pro Leu Gly Cys Tyr  Arg Asp Pro 
    1280                 1285                 1290             


Asp Ala  Ile Ile Lys Thr Ile  Leu Gln His Gln Val  Thr Thr Leu 
    1295                 1300                 1305             


Gln Cys  Val Pro Thr Leu Leu  Gln Ala Leu Leu Asp  Asn Pro Asn 
    1310                 1315                 1320             


Phe Leu  Asp Cys Leu Ser Leu  Thr Gln Val Phe Ser  Gly Gly Glu 
    1325                 1330                 1335             


Ala Leu  Thr Thr Lys Leu Ala  Thr Gln Phe Leu Asn  Ser Phe Thr 
    1340                 1345                 1350             


His Cys  Glu Leu Ile Asn Leu  Tyr Gly Pro Thr Glu  Cys Thr Ile 
    1355                 1360                 1365             


Asn Ser  Ser Phe Phe Arg Val  Thr Asn Glu Thr Leu  Pro Asn Tyr 
    1370                 1375                 1380             


Gln Thr  Ser Ile Ser Ile Gly  Ala Pro Val Asp Asn  Thr Glu Tyr 
    1385                 1390                 1395             


Tyr Val  Leu Asp Asp Asp Arg  Leu Pro Val Ala Val  Gly Glu Ile 
    1400                 1405                 1410             


Gly Glu  Leu Tyr Ile Ser Gly  Ala Gln Leu Ala Arg  Gly Tyr Leu 
    1415                 1420                 1425             


His Lys  Pro Glu Met Thr Lys  Asp Lys Phe Ile Cys  Asn His Leu 
    1430                 1435                 1440             


Val Ser  Gly Thr Gln His Gln  Trp Leu Tyr Arg Thr  Gly Asp Leu 
    1445                 1450                 1455             


Val Thr  Arg Gly Ala Asp Gly  Asn Thr Tyr Phe Val  Gly Arg Val 
    1460                 1465                 1470             


Asp Ser  Gln Val Lys Leu Arg  Gly Tyr Arg Ile Glu  Leu Asp Glu 
    1475                 1480                 1485             


Ile Arg  His Ala Ile Glu Glu  His Ser Trp Ile Lys  Thr Ala Ala 
    1490                 1495                 1500             


Met Leu  Ile Lys Lys Asp Ala  Arg Thr Gly Phe Gln  Asn Leu Ile 
    1505                 1510                 1515             


Ala Cys  Val Glu Leu Asp Glu  Lys Glu Ala Ala Leu  Met Asp Gln 
    1520                 1525                 1530             


Gly Asn  Ser Ser Ser His His  Lys Ser Lys Ala Asp  Lys Leu Gln 
    1535                 1540                 1545             


Val Lys  Ala Gln Leu Ser Asn  Ser Gly Cys Arg Ser  Glu Glu Leu 
    1550                 1555                 1560             


Cys Glu  Asn Arg Pro Thr Phe  Leu Leu Pro Tyr Gln  Glu Gly Glu 
    1565                 1570                 1575             


Ile Lys  Gln Arg Glu Tyr Ala  Phe Gly Arg Lys Thr  Tyr Arg Tyr 
    1580                 1585                 1590             


Phe Glu  Gly Thr Glu Ile Thr  Val Glu Lys Leu Lys  Lys Leu Leu 
    1595                 1600                 1605             


Thr Ala  Thr Gln Ser Asn Glu  Ile Ser Ser Leu Pro  Leu Ser His 
    1610                 1615                 1620             


Leu Thr  Leu Asn Asp Phe Gly  Tyr Ala Leu Arg Tyr  Phe Gly Gln 
    1625                 1630                 1635             


Phe Thr  Ser His Gln Arg Leu  Leu Pro Lys Tyr Ala  Tyr Ala Ser 
    1640                 1645                 1650             


Pro Gly  Ala Leu Tyr Ala Thr  Gln Met Tyr Phe Glu  Leu His Asn 
    1655                 1660                 1665             


Val Leu  Gly Leu Asp Ala Gly  Ile Tyr Tyr Tyr His  Pro Val Thr 
    1670                 1675                 1680             


His Lys  Leu Ile Lys Ile Ser  Thr Leu Ser Arg Arg  Gln Met Pro 
    1685                 1690                 1695             


Thr Ile  Lys Val His Phe Ile  Gly Lys His Glu Ala  Ile Glu Pro 
    1700                 1705                 1710             


Val Tyr  Lys Asn Asn Ile Gln  Glu Val Leu Glu Met  Glu Ala Gly 
    1715                 1720                 1725             


His Met  Met Gly Leu Phe Asp  Asp Val Leu Pro Glu  Ile Gly Leu 
    1730                 1735                 1740             


Ser Ile  Gly Lys Ser Glu Tyr  Gln Asp Glu Cys Pro  Asp Trp Tyr 
    1745                 1750                 1755             


Asp Gly  Asp Ile Gln Asp Tyr  Tyr Leu Gly Ala Phe  Glu Ile Cys 
    1760                 1765                 1770             


Ser Tyr  Glu His Gly Leu Pro  Pro Phe Glu Thr Asp  Ile Tyr Leu 
    1775                 1780                 1785             


Gln Thr  His Ala His Lys Ile  Pro Glu Met Pro Cys  Gly Leu Tyr 
    1790                 1795                 1800             


His Phe  Ser Asn Gly Glu Phe  Val Arg Ile Ser Asp  Asp Ile Val 
    1805                 1810                 1815             


Arg Lys  Lys Asp Val Ile Ala  Ile Asn Gln Gln Val  Tyr Asp Arg 
    1820                 1825                 1830             


Ser Ser  Phe Gly Val Ser Ile  Ile Pro Arg Cys Val  Pro Glu Trp 
    1835                 1840                 1845             


His Tyr  Tyr Ile Thr Leu Gly  Arg Arg Leu His Ala  Leu Gln Ser 
    1850                 1855                 1860             


Asn Pro  Leu Tyr Ile Gly Leu  Met Ser Ser Gly Tyr  Ser Ser Lys 
    1865                 1870                 1875             


Ser Asn  Asn Asp Leu Pro Ser  Ala Lys Arg Met Arg  Ser Ile Leu 
    1880                 1885                 1890             


Asn Ala  Leu Asp Arg Pro Met  Ala Ala Phe Tyr Phe  Cys Ile Gly 
    1895                 1900                 1905             


Gly Gly  Ile Ser Gln Ala Gln  Tyr Met Cys Glu Gly  Met Lys Glu 
    1910                 1915                 1920             


Asp Val  Val His Met Lys Gly  Pro Val Glu Ile Ile  Lys Asp Asp 
    1925                 1930                 1935             


Leu Gln  Gln Gln Leu Pro Gln  Tyr Met Ile Pro Asn  Lys Val Leu 
    1940                 1945                 1950             


Val Phe  Asp Lys Leu Pro Leu  Thr Ala Asn Gly Lys  Val Asp Tyr 
    1955                 1960                 1965             


Gln Ser  Leu Ser Glu Ser Lys  Ala Val Glu Asn Val  Ser Thr Gln 
    1970                 1975                 1980             


Arg Leu  Leu Val Pro Leu His  Thr Asp Thr Glu Ile  Arg Leu Gly 
    1985                 1990                 1995             


Lys Ile  Trp Met Glu Val Leu  Lys Trp Asp Ser Val  Ser Ala Leu 
    2000                 2005                 2010             


Asp Asp  Phe Phe Glu Ser Gly  Gly Asn Ser Leu Met  Ala Val Ala 
    2015                 2020                 2025             


Met Val  Asn Lys Ile Asn Ala  Ala Phe Asn Ile Arg  Phe Pro Leu 
    2030                 2035                 2040             


Gln Ile  Leu Phe Gln Ser Pro  Asn Ile Ala Glu Leu  Ala Lys Trp 
    2045                 2050                 2055             


Ile Glu  Gln Thr Asp Ser Lys  Thr Ile Ser Arg Leu  Ile Leu Leu 
    2060                 2065                 2070             


Asn Gln  Ala Ser Lys Asp Pro  Ile Tyr Cys Trp Pro  Gly Leu Gly 
    2075                 2080                 2085             


Gly Tyr  Pro Met Ser Leu Arg  Leu Leu Ala Asn Lys  Val Val Pro 
    2090                 2095                 2100             


Asp Arg  Ala Phe Tyr Gly Ile  Gln Ala Tyr Gly Ile  Asn Glu Ser 
    2105                 2110                 2115             


Glu Ile  Pro Phe Ser Ser Ile  Gln Arg Met Ala Glu  Glu Asp Ile 
    2120                 2125                 2130             


Lys Glu  Ile Lys Lys Ile Gln  Pro Glu Gly Pro Tyr  Ile Leu Trp 
    2135                 2140                 2145             


Gly Tyr  Ser Phe Gly Ala Arg  Val Ala Phe Glu Val  Ala Tyr Gln 
    2150                 2155                 2160             


Leu Glu  Gln Ala Gly Glu Glu  Val Asn Ala Leu Asn  Leu Leu Ala 
    2165                 2170                 2175             


Pro Gly  Ser Pro His Leu Asp  Met Lys Gln Ala Glu  Tyr Met Asp 
    2180                 2185                 2190             


Lys Gly  Ala Glu Phe Thr Asn  Pro Ala Phe Val Lys  Ile Leu Phe 
    2195                 2200                 2205             


Ser Val  Phe Ser Arg Ser Ile  Asn Ser Pro Met Val  Lys Thr Cys 
    2210                 2215                 2220             


Leu Glu  Gln Val Asn Ser Glu  Thr Thr Phe Ile Asn  Phe Ile Cys 
    2225                 2230                 2235             


Ser Arg  Phe Lys Asn Leu Glu  Pro Ser Leu Val Lys  Arg Ile Val 
    2240                 2245                 2250             


Arg Ile  Val Thr Leu Thr Tyr  Asp Phe Lys Tyr Ser  Ile Asp Glu 
    2255                 2260                 2265             


Leu Tyr  His Arg His Leu Lys  Ala Pro Ile Thr Ile  Phe Lys Ala 
    2270                 2275                 2280             


Asn Arg  Asp Asn Asp Ser Phe  Ile Glu Glu Ser Asp  Val Ile Ser 
    2285                 2290                 2295             


Ser Met  Ser Pro Lys Ile Ile  Glu Leu Ile Ser Asp  His Tyr Gln 
    2300                 2305                 2310             


Leu Leu  Glu Ser Glu Gly Val  Ala Glu Ile Glu Lys  Ile Ile 
    2315                 2320                 2325         


<210>  28
<211>  3221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Indigoidine-tagged Dipeptide consisting of
       Ornithine and Valine

<400>  28

Met Leu His Ser Phe Leu Ala Thr Lys Thr Ala Tyr Pro Thr Asp Lys 
1               5                   10                  15      


Thr Phe Gln Lys Leu Phe Glu Glu Gln Val Glu Lys Thr Pro Asn Glu 
            20                  25                  30          


Ile Ala Val Leu Phe Gly Asn Glu Gln Leu Thr Tyr Gln Glu Leu Asn 
        35                  40                  45              


Ala Lys Ala Asn Gln Leu Ala Arg Val Leu Arg Arg Lys Gly Val Lys 
    50                  55                  60                  


Pro Glu Ser Thr Val Gly Ile Leu Val Asp Arg Ser Leu Tyr Met Val 
65                  70                  75                  80  


Ile Gly Met Leu Ala Val Leu Lys Ala Gly Gly Thr Phe Val Pro Ile 
                85                  90                  95      


Asp Pro Asp Tyr Pro Leu Glu Arg Gln Ala Phe Met Leu Glu Asp Ser 
            100                 105                 110         


Glu Ala Lys Leu Leu Leu Thr Leu Gln Lys Met Asn Ser Gln Val Ala 
        115                 120                 125             


Phe Pro Tyr Glu Thr Phe Tyr Leu Asp Thr Glu Thr Val Asp Gln Glu 
    130                 135                 140                 


Glu Thr Gly Asn Leu Glu His Val Ala Gln Pro Glu Asn Val Ala Tyr 
145                 150                 155                 160 


Ile Ile Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Val Val Ile 
                165                 170                 175     


Glu His Arg Ser Tyr Ala Asn Val Ala Phe Ala Trp Lys Asp Glu Tyr 
            180                 185                 190         


His Leu Asp Ser Phe Pro Val Arg Leu Leu Gln Met Ala Ser Phe Ala 
        195                 200                 205             


Phe Asp Val Ser Thr Gly Asp Phe Ala Arg Ala Leu Leu Thr Gly Gly 
    210                 215                 220                 


Gln Leu Val Ile Cys Pro Asn Gly Val Lys Met Asp Pro Ala Ser Leu 
225                 230                 235                 240 


Tyr Glu Thr Ile Arg Arg His Glu Ile Thr Ile Phe Glu Ala Thr Pro 
                245                 250                 255     


Ala Leu Ile Met Pro Leu Met His Tyr Val Tyr Glu Asn Glu Leu Asp 
            260                 265                 270         


Met Ser Gln Met Lys Leu Leu Ile Leu Gly Ala Asp Ser Cys Pro Ala 
        275                 280                 285             


Glu Asp Phe Lys Thr Leu Leu Ala Arg Phe Gly Gln Lys Met Arg Ile 
    290                 295                 300                 


Ile Asn Ser Tyr Gly Val Thr Glu Ala Cys Ile Asp Thr Ser Tyr Tyr 
305                 310                 315                 320 


Glu Glu Thr Asp Val Thr Ala Ile Arg Ser Gly Thr Val Pro Ile Gly 
                325                 330                 335     


Lys Pro Leu Pro Asn Met Thr Met Tyr Val Val Asp Ala His Leu Asn 
            340                 345                 350         


Leu Gln Pro Val Gly Val Val Gly Glu Leu Cys Ile Gly Gly Ala Gly 
        355                 360                 365             


Val Ala Arg Gly Tyr Leu Asn Arg Pro Glu Leu Thr Glu Glu Lys Phe 
    370                 375                 380                 


Val Pro Asn Pro Phe Ala Pro Gly Glu Arg Leu Tyr Arg Thr Gly Asp 
385                 390                 395                 400 


Leu Ala Lys Trp Arg Ala Asp Gly Asn Val Glu Phe Leu Gly Arg Asn 
                405                 410                 415     


Asp His Gln Val Lys Ile Arg Gly Val Arg Ile Glu Leu Gly Glu Ile 
            420                 425                 430         


Glu Thr Gln Leu Arg Lys Leu Asp Gly Ile Thr Glu Ala Val Val Val 
        435                 440                 445             


Ala Arg Glu Asp Arg Gly Gln Glu Lys Glu Leu Cys Ala Tyr Val Val 
    450                 455                 460                 


Ala Asp His Lys Leu Asp Thr Ala Glu Leu Arg Ala Asn Leu Leu Lys 
465                 470                 475                 480 


Glu Leu Pro Gln Ala Met Ile Pro Ala Tyr Phe Val Thr Leu Asp Ala 
                485                 490                 495     


Leu Pro Leu Thr Ala Asn Gly Lys Val Asp Arg Arg Ser Leu Pro Ala 
            500                 505                 510         


Pro Asp Val Thr Met Leu Arg Thr Thr Glu Tyr Val Ala Pro Arg Ser 
        515                 520                 525             


Val Trp Glu Ala Arg Leu Ala Gln Val Trp Glu Gln Val Leu Asn Val 
    530                 535                 540                 


Pro Gln Val Gly Ala Leu Asp Asp Phe Phe Ala Leu Gly Gly His Ser 
545                 550                 555                 560 


Leu Arg Ala Met Arg Val Leu Ser Ser Met His Asn Glu Tyr Gln Val 
                565                 570                 575     


Asp Ile Pro Leu Arg Ile Leu Phe Glu Lys Pro Thr Ile Gln Glu Leu 
            580                 585                 590         


Ala Ala Phe Ile Glu Thr Ser Gly Lys Glu Thr Tyr Val Pro Ile Glu 
        595                 600                 605             


Pro Ala Pro Leu Gln Glu Tyr Tyr Pro Val Ser Ser Ala Gln Lys Arg 
    610                 615                 620                 


Met Tyr Val Leu Arg Gln Phe Ala Asp Thr Gly Thr Val Tyr Asn Met 
625                 630                 635                 640 


Pro Ser Ala Leu Tyr Ile Glu Gly Asp Leu Asp Arg Lys Arg Phe Glu 
                645                 650                 655     


Ala Ala Ile His Gly Leu Val Glu Arg His Glu Ser Leu Arg Thr Ser 
            660                 665                 670         


Phe His Thr Val Asn Gly Glu Pro Val Gln Arg Val His Glu His Val 
        675                 680                 685             


Glu Leu Asn Val Gln Tyr Ala Glu Val Thr Glu Ala Gln Val Glu Pro 
    690                 695                 700                 


Thr Val Glu Ser Phe Val Gln Ala Phe Asp Leu Thr Lys Ala Pro Leu 
705                 710                 715                 720 


Leu Arg Val Gly Leu Phe Lys Leu Ala Ala Lys Arg His Leu Phe Leu 
                725                 730                 735     


Leu Asp Met His His Ile Ile Ser Asp Gly Val Ser Ala Gly Ile Ile 
            740                 745                 750         


Met Glu Glu Phe Ser Lys Leu Tyr Arg Gly Glu Glu Leu Pro Ala Leu 
        755                 760                 765             


Ser Val His Tyr Lys Asp Phe Ala Val Trp Gln Ser Glu Leu Phe Gln 
    770                 775                 780                 


Ser Asp Val Tyr Thr Glu His Glu Asn Tyr Trp Leu Asn Ala Phe Ser 
785                 790                 795                 800 


Gly Asp Ile Pro Val Leu Asn Leu Pro Ala Asp Phe Ser Arg Pro Leu 
                805                 810                 815     


Thr Gln Ser Phe Glu Gly Asp Cys Val Ser Phe Gln Ala Asp Lys Ala 
            820                 825                 830         


Leu Leu Asp Asp Leu His Lys Leu Ala Gln Glu Ser Gln Ser Thr Leu 
        835                 840                 845             


Phe Met Val Leu Leu Ala Ala Tyr Asn Val Leu Leu Ala Lys Tyr Ser 
    850                 855                 860                 


Gly Gln Glu Asp Ile Val Val Gly Thr Pro Ile Ala Gly Arg Ser His 
865                 870                 875                 880 


Ala Asp Ile Glu Asn Val Leu Gly Met Phe Val Asn Thr Leu Ala Leu 
                885                 890                 895     


Arg Asn Tyr Pro Val Glu Thr Lys His Phe Gln Ala Phe Leu Glu Glu 
            900                 905                 910         


Val Lys Gln Asn Thr Leu Gln Ala Tyr Ala His Gln Asp Tyr Pro Phe 
        915                 920                 925             


Glu Ala Leu Val Glu Lys Leu Asp Ile Gln Arg Asp Leu Ser Arg Asn 
    930                 935                 940                 


Pro Leu Phe Asp Thr Met Phe Ile Leu Gln Asn Leu Asp Gln Lys Ala 
945                 950                 955                 960 


Tyr Glu Leu Asp Gly Leu Lys Leu Glu Ala Tyr Pro Ala Gln Ala Gly 
                965                 970                 975     


Asn Ala Lys Phe Asp Leu Thr Leu Glu Ala His Glu Asp Glu Thr Gly 
            980                 985                 990         


Ile His Phe Ala Leu Val Tyr Ser  Thr Lys Leu Phe Gln  Arg Glu Ser 
        995                 1000                 1005             


Ile Glu  Arg Met Ala Gly His  Phe Leu Gln Val Leu  Arg Gln Val 
    1010                 1015                 1020             


Val Ala  Asp Gln Ala Thr Ala  Leu Arg Glu Ile Ser  Leu Leu Ser 
    1025                 1030                 1035             


Glu Glu  Glu Arg Arg Ile Val  Thr Val Asp Phe Asn  Asn Thr Phe 
    1040                 1045                 1050             


Ala Tyr  Pro Arg Asp Leu Thr  Ile Gln Glu Leu Phe  Glu Gln Gln 
    1055                 1060                 1065             


Ala Ala  Lys Thr Pro Glu His  Ala Ala Val Val Met  Asp Gly Gln 
    1070                 1075                 1080             


Met Leu  Thr Tyr Arg Glu Leu  Asn Glu Lys Ala Asn  Gln Leu Ala 
    1085                 1090                 1095             


His Val  Leu Arg Gln Asn Gly  Val Gly Lys Glu Ser  Ile Val Gly 
    1100                 1105                 1110             


Leu Leu  Ala Asp Arg Ser Leu  Glu Met Ile Thr Gly  Ile Met Gly 
    1115                 1120                 1125             


Ile Leu  Lys Ala Gly Gly Ala  Tyr Leu Gly Leu Asp  Pro Glu His 
    1130                 1135                 1140             


Pro Ser  Glu Arg Leu Ala Tyr  Met Leu Glu Asp Gly  Gly Val Lys 
    1145                 1150                 1155             


Val Val  Leu Val Gln Lys His  Leu Leu Pro Leu Val  Gly Glu Gly 
    1160                 1165                 1170             


Leu Met  Pro Ile Val Leu Glu  Glu Glu Ser Leu Arg  Pro Glu Asp 
    1175                 1180                 1185             


Cys Gly  Asn Pro Ala Ile Val  Asn Gly Ala Ser Asp  Leu Ala Tyr 
    1190                 1195                 1200             


Val Met  Tyr Thr Ser Gly Ser  Thr Gly Lys Pro Lys  Gly Val Met 
    1205                 1210                 1215             


Val Glu  His Arg Asn Val Thr  Arg Leu Val Met His  Thr Asn Tyr 
    1220                 1225                 1230             


Val Gln  Val Arg Glu Ser Asp  Arg Met Ile Gln Thr  Gly Ala Ile 
    1235                 1240                 1245             


Gly Phe  Asp Ala Met Thr Phe  Glu Ile Phe Gly Ala  Leu Leu His 
    1250                 1255                 1260             


Gly Ala  Ser Leu Tyr Leu Val  Ser Lys Asp Val Leu  Leu Asp Ala 
    1265                 1270                 1275             


Glu Lys  Leu Gly Asp Phe Leu  Arg Thr Asn Gln Ile  Thr Thr Met 
    1280                 1285                 1290             


Trp Leu  Thr Ser Pro Leu Phe  Asn Gln Leu Ser Gln  Asp Asn Pro 
    1295                 1300                 1305             


Ala Met  Phe Asp Ser Leu Arg  Ala Leu Ile Val Gly  Gly Glu Ala 
    1310                 1315                 1320             


Leu Ser  Pro Lys His Ile Asn  Arg Val Lys Ser Ala  Leu Pro Asp 
    1325                 1330                 1335             


Leu Glu  Ile Trp Asn Gly Tyr  Gly Pro Thr Glu Asn  Thr Thr Phe 
    1340                 1345                 1350             


Ser Thr  Cys Tyr Leu Ile Glu  Gln His Phe Glu Glu  Gln Ile Pro 
    1355                 1360                 1365             


Ile Gly  Lys Pro Ile Ala Asn  Ser Thr Ala Tyr Ile  Val Asp Gly 
    1370                 1375                 1380             


Asn Asn  Gln Pro Gln Pro Ile  Gly Val Pro Gly Glu  Leu Cys Val 
    1385                 1390                 1395             


Gly Gly  Asp Gly Val Ala Arg  Gly Tyr Val Asn Lys  Pro Glu Leu 
    1400                 1405                 1410             


Thr Ala  Glu Lys Phe Val Pro  Asn Pro Phe Ala Pro  Gly Glu Thr 
    1415                 1420                 1425             


Met Tyr  Arg Thr Gly Asp Leu  Ala Arg Trp Leu Pro  Asp Gly Thr 
    1430                 1435                 1440             


Ile Glu  Tyr Leu Gly Arg Ile  Asp Gln Gln Val Lys  Ile Arg Gly 
    1445                 1450                 1455             


Tyr Arg  Ile Glu Leu Gly Glu  Ile Glu Thr Val Leu  Ser Gln Gln 
    1460                 1465                 1470             


Ala Gln  Val Lys Glu Ala Val  Val Ala Val Ile Glu  Glu Ala Asn 
    1475                 1480                 1485             


Gly Gln  Lys Ala Leu Cys Ala  Tyr Phe Val Pro Glu  Gln Ala Val 
    1490                 1495                 1500             


Asp Ala  Ala Glu Leu Arg Glu  Ala Met Ser Lys Gln  Leu Pro Gly 
    1505                 1510                 1515             


Tyr Met  Val Pro Ala Tyr Tyr  Val Gln Met Glu Lys  Leu Pro Leu 
    1520                 1525                 1530             


Thr Ala  Asn Gly Lys Val Asp  Arg Arg Ala Leu Pro  Gln Pro Ser 
    1535                 1540                 1545             


Gly Glu  Arg Thr Thr Gly Ser  Ala Phe Val Ala Ala  Gln Asn Asp 
    1550                 1555                 1560             


Thr Glu  Ala Lys Leu Gln Gln  Ile Trp Gln Glu Val  Leu Gly Ile 
    1565                 1570                 1575             


Pro Ala  Ile Gly Ile His Asp  Asn Phe Phe Glu Ile  Gly Gly His 
    1580                 1585                 1590             


Ser Leu  Lys Ala Met Asn Val  Ile Thr Gln Val His  Lys Thr Phe 
    1595                 1600                 1605             


Gln Val  Glu Leu Pro Leu Lys  Ala Leu Phe Ala Thr  Pro Thr Ile 
    1610                 1615                 1620             


His Glu  Leu Ala Ala His Ile  Ser Glu Lys Thr Glu  Tyr Thr Ala 
    1625                 1630                 1635             


Ile Gln  Pro Val Ala Ala Gln  Glu Phe Tyr Pro Val  Ser Ser Ala 
    1640                 1645                 1650             


Gln Lys  Arg Met Tyr Ile Leu  Gln Gln Phe Glu Gly  Asn Gly Ile 
    1655                 1660                 1665             


Ser Tyr  Asn Ile Ser Gly Ala  Ile Leu Leu Glu Gly  Lys Leu Asp 
    1670                 1675                 1680             


Tyr Ala  Arg Phe Ala Ser Ala  Val Gln Gln Leu Ala  Glu Arg His 
    1685                 1690                 1695             


Glu Ala  Leu Arg Thr Ser Phe  His Arg Ile Asp Gly  Glu Pro Val 
    1700                 1705                 1710             


Gln Lys  Val His Glu Glu Val  Glu Val Pro Leu Phe  Met Leu Glu 
    1715                 1720                 1725             


Ala Pro  Glu Asp Gln Ala Glu  Lys Ile Met Arg Glu  Phe Val Arg 
    1730                 1735                 1740             


Pro Phe  Asp Leu Gly Val Ala  Pro Leu Met Arg Thr  Gly Leu Leu 
    1745                 1750                 1755             


Lys Leu  Gly Lys Asp Arg His  Leu Phe Leu Leu Asp  Met His His 
    1760                 1765                 1770             


Ile Ile  Ser Asp Gly Val Ser  Ser Gln Ile Leu Leu  Arg Glu Phe 
    1775                 1780                 1785             


Ala Glu  Leu Tyr Gln Gly Ala  Asp Leu Gln Pro Leu  Ser Leu Gln 
    1790                 1795                 1800             


Tyr Lys  Asp Phe Ala Ala Trp  Gln Asn Glu Leu Phe  Gln Thr Glu 
    1805                 1810                 1815             


Ala Tyr  Lys Lys Gln Glu Gln  His Trp Leu Asn Thr  Phe Ala Asp 
    1820                 1825                 1830             


Glu Ile  Pro Leu Leu Asn Leu  Pro Thr Asp Tyr Pro  Arg Pro Ser 
    1835                 1840                 1845             


Val Gln  Ser Phe Ala Gly Asp  Leu Val Leu Phe Ala  Ala Gly Lys 
    1850                 1855                 1860             


Glu Leu  Leu Glu Arg Leu Gln  Gln Val Ala Ser Glu  Thr Gly Thr 
    1865                 1870                 1875             


Thr Leu  Tyr Met Ile Leu Leu  Ala Ala Tyr Asn Val  Leu Leu Ser 
    1880                 1885                 1890             


Lys Tyr  Thr Gly Gln Glu Asp  Ile Ile Val Gly Thr  Pro Val Ala 
    1895                 1900                 1905             


Gly Arg  Ser His Ala Asp Val  Glu Asn Ile Met Gly  Ile Phe Val 
    1910                 1915                 1920             


Asn Thr  Leu Ala Leu Arg Asn  Gln Pro Ala Ser Ser  Lys Thr Met 
    1925                 1930                 1935             


Leu Glu  Asn Asn Ile Thr Gln  Cys Asp Ser Ile Asn  Asp Val Tyr 
    1940                 1945                 1950             


Leu Lys  Glu Glu Ala Ile Thr  Leu Met Asp Met Leu  Glu Ser Gln 
    1955                 1960                 1965             


Leu Lys  His Gln Ala Asp Gly  Tyr Val Val Ile Asp  Gln Glu Glu 
    1970                 1975                 1980             


Ser Leu  Ser Tyr Ala Asp Phe  Tyr Leu Arg Val Lys  Glu Ile Gly 
    1985                 1990                 1995             


Tyr Cys  Leu Ser Glu Ile Ser  Ser Lys Asn Ser Val  Gly Ile Gly 
    2000                 2005                 2010             


Leu Phe  Cys Asp Pro Ser Ile  Asp Leu Ile Cys Gly  Ala Trp Gly 
    2015                 2020                 2025             


Ile Leu  Ser Ala Asp Lys Ala  Tyr Leu Pro Leu Ser  Pro Asp Tyr 
    2030                 2035                 2040             


Pro Thr  Glu Arg Leu Lys Tyr  Met Ile Glu Asp Ser  Gly Ile Asp 
    2045                 2050                 2055             


Val Ile  Phe Thr Gln Ser His  Leu Lys Ala Gln Leu  Gln Asp Ile 
    2060                 2065                 2070             


Ala Pro  Lys Ser Val Leu Ile  Met Thr Pro Glu Asp  Val Ala Leu 
    2075                 2080                 2085             


Thr Ile  Lys Thr Arg Thr Ile  Glu Asp Ile Leu Gly  Thr Val Gln 
    2090                 2095                 2100             


Val Pro  Lys Pro Thr Ser Leu  Ala Tyr Ile Ile Tyr  Thr Ser Gly 
    2105                 2110                 2115             


Ser Thr  Gly Lys Pro Lys Gly  Val Met Ile Glu His  His Ser Ile 
    2120                 2125                 2130             


Val Asn  Gln Met Arg Phe Leu  Ala Lys Ala Phe Lys  Leu Gly Cys 
    2135                 2140                 2145             


His Ser  Arg Ile Leu Gln Lys  Thr Pro Met Ser Phe  Asp Ala Ala 
    2150                 2155                 2160             


Gln Trp  Glu Ile Leu Ala Pro  Ala Ile Gly Gly Gln  Val Ile Met 
    2165                 2170                 2175             


Gly Pro  Leu Gly Cys Tyr Arg  Asp Pro Asp Ala Ile  Ile Lys Thr 
    2180                 2185                 2190             


Ile Leu  Gln His Gln Val Thr  Thr Leu Gln Cys Val  Pro Thr Leu 
    2195                 2200                 2205             


Leu Gln  Ala Leu Leu Asp Asn  Pro Asn Phe Leu Asp  Cys Leu Ser 
    2210                 2215                 2220             


Leu Thr  Gln Val Phe Ser Gly  Gly Glu Ala Leu Thr  Thr Lys Leu 
    2225                 2230                 2235             


Ala Thr  Gln Phe Leu Asn Ser  Phe Thr His Cys Glu  Leu Ile Asn 
    2240                 2245                 2250             


Leu Tyr  Gly Pro Thr Glu Cys  Thr Ile Asn Ser Ser  Phe Phe Arg 
    2255                 2260                 2265             


Val Thr  Asn Glu Thr Leu Pro  Asn Tyr Gln Thr Ser  Ile Ser Ile 
    2270                 2275                 2280             


Gly Ala  Pro Val Asp Asn Thr  Glu Tyr Tyr Val Leu  Asp Asp Asp 
    2285                 2290                 2295             


Arg Leu  Pro Val Ala Val Gly  Glu Ile Gly Glu Leu  Tyr Ile Ser 
    2300                 2305                 2310             


Gly Ala  Gln Leu Ala Arg Gly  Tyr Leu His Lys Pro  Glu Met Thr 
    2315                 2320                 2325             


Lys Asp  Lys Phe Ile Cys Asn  His Leu Val Ser Gly  Thr Gln His 
    2330                 2335                 2340             


Gln Trp  Leu Tyr Arg Thr Gly  Asp Leu Val Thr Arg  Gly Ala Asp 
    2345                 2350                 2355             


Gly Asn  Thr Tyr Phe Val Gly  Arg Val Asp Ser Gln  Val Lys Leu 
    2360                 2365                 2370             


Arg Gly  Tyr Arg Ile Glu Leu  Asp Glu Ile Arg His  Ala Ile Glu 
    2375                 2380                 2385             


Glu His  Ser Trp Ile Lys Thr  Ala Ala Met Leu Ile  Lys Lys Asp 
    2390                 2395                 2400             


Ala Arg  Thr Gly Phe Gln Asn  Leu Ile Ala Cys Val  Glu Leu Asp 
    2405                 2410                 2415             


Glu Lys  Glu Ala Ala Leu Met  Asp Gln Gly Asn Ser  Ser Ser His 
    2420                 2425                 2430             


His Lys  Ser Lys Ala Asp Lys  Leu Gln Val Lys Ala  Gln Leu Ser 
    2435                 2440                 2445             


Asn Ser  Gly Cys Arg Ser Glu  Glu Leu Cys Glu Asn  Arg Pro Thr 
    2450                 2455                 2460             


Phe Leu  Leu Pro Tyr Gln Glu  Gly Glu Ile Lys Gln  Arg Glu Tyr 
    2465                 2470                 2475             


Ala Phe  Gly Arg Lys Thr Tyr  Arg Tyr Phe Glu Gly  Thr Glu Ile 
    2480                 2485                 2490             


Thr Val  Glu Lys Leu Lys Lys  Leu Leu Thr Ala Thr  Gln Ser Asn 
    2495                 2500                 2505             


Glu Ile  Ser Ser Leu Pro Leu  Ser His Leu Thr Leu  Asn Asp Phe 
    2510                 2515                 2520             


Gly Tyr  Ala Leu Arg Tyr Phe  Gly Gln Phe Thr Ser  His Gln Arg 
    2525                 2530                 2535             


Leu Leu  Pro Lys Tyr Ala Tyr  Ala Ser Pro Gly Ala  Leu Tyr Ala 
    2540                 2545                 2550             


Thr Gln  Met Tyr Phe Glu Leu  His Asn Val Leu Gly  Leu Asp Ala 
    2555                 2560                 2565             


Gly Ile  Tyr Tyr Tyr His Pro  Val Thr His Lys Leu  Ile Lys Ile 
    2570                 2575                 2580             


Ser Thr  Leu Ser Arg Arg Gln  Met Pro Thr Ile Lys  Val His Phe 
    2585                 2590                 2595             


Ile Gly  Lys His Glu Ala Ile  Glu Pro Val Tyr Lys  Asn Asn Ile 
    2600                 2605                 2610             


Gln Glu  Val Leu Glu Met Glu  Ala Gly His Met Met  Gly Leu Phe 
    2615                 2620                 2625             


Asp Asp  Val Leu Pro Glu Ile  Gly Leu Ser Ile Gly  Lys Ser Glu 
    2630                 2635                 2640             


Tyr Gln  Asp Glu Cys Pro Asp  Trp Tyr Asp Gly Asp  Ile Gln Asp 
    2645                 2650                 2655             


Tyr Tyr  Leu Gly Ala Phe Glu  Ile Cys Ser Tyr Glu  His Gly Leu 
    2660                 2665                 2670             


Pro Pro  Phe Glu Thr Asp Ile  Tyr Leu Gln Thr His  Ala His Lys 
    2675                 2680                 2685             


Ile Pro  Glu Met Pro Cys Gly  Leu Tyr His Phe Ser  Asn Gly Glu 
    2690                 2695                 2700             


Phe Val  Arg Ile Ser Asp Asp  Ile Val Arg Lys Lys  Asp Val Ile 
    2705                 2710                 2715             


Ala Ile  Asn Gln Gln Val Tyr  Asp Arg Ser Ser Phe  Gly Val Ser 
    2720                 2725                 2730             


Ile Ile  Pro Arg Cys Val Pro  Glu Trp His Tyr Tyr  Ile Thr Leu 
    2735                 2740                 2745             


Gly Arg  Arg Leu His Ala Leu  Gln Ser Asn Pro Leu  Tyr Ile Gly 
    2750                 2755                 2760             


Leu Met  Ser Ser Gly Tyr Ser  Ser Lys Ser Asn Asn  Asp Leu Pro 
    2765                 2770                 2775             


Ser Ala  Lys Arg Met Arg Ser  Ile Leu Asn Ala Leu  Asp Arg Pro 
    2780                 2785                 2790             


Met Ala  Ala Phe Tyr Phe Cys  Ile Gly Gly Gly Ile  Ser Gln Ala 
    2795                 2800                 2805             


Gln Tyr  Met Cys Glu Gly Met  Lys Glu Asp Val Val  His Met Lys 
    2810                 2815                 2820             


Gly Pro  Val Glu Ile Ile Lys  Asp Asp Leu Gln Gln  Gln Leu Pro 
    2825                 2830                 2835             


Gln Tyr  Met Ile Pro Asn Lys  Val Leu Val Phe Asp  Lys Leu Pro 
    2840                 2845                 2850             


Leu Thr  Ala Asn Gly Lys Val  Asp Tyr Gln Ser Leu  Ser Glu Ser 
    2855                 2860                 2865             


Lys Ala  Val Glu Asn Val Ser  Thr Gln Arg Leu Leu  Val Pro Leu 
    2870                 2875                 2880             


His Thr  Asp Thr Glu Ile Arg  Leu Gly Lys Ile Trp  Met Glu Val 
    2885                 2890                 2895             


Leu Lys  Trp Asp Ser Val Ser  Ala Leu Asp Asp Phe  Phe Glu Ser 
    2900                 2905                 2910             


Gly Gly  Asn Ser Leu Met Ala  Val Ala Met Val Asn  Lys Ile Asn 
    2915                 2920                 2925             


Ala Ala  Phe Asn Ile Arg Phe  Pro Leu Gln Ile Leu  Phe Gln Ser 
    2930                 2935                 2940             


Pro Asn  Ile Ala Glu Leu Ala  Lys Trp Ile Glu Gln  Thr Asp Ser 
    2945                 2950                 2955             


Lys Thr  Ile Ser Arg Leu Ile  Leu Leu Asn Gln Ala  Ser Lys Asp 
    2960                 2965                 2970             


Pro Ile  Tyr Cys Trp Pro Gly  Leu Gly Gly Tyr Pro  Met Ser Leu 
    2975                 2980                 2985             


Arg Leu  Leu Ala Asn Lys Val  Val Pro Asp Arg Ala  Phe Tyr Gly 
    2990                 2995                 3000             


Ile Gln  Ala Tyr Gly Ile Asn  Glu Ser Glu Ile Pro  Phe Ser Ser 
    3005                 3010                 3015             


Ile Gln  Arg Met Ala Glu Glu  Asp Ile Lys Glu Ile  Lys Lys Ile 
    3020                 3025                 3030             


Gln Pro  Glu Gly Pro Tyr Ile  Leu Trp Gly Tyr Ser  Phe Gly Ala 
    3035                 3040                 3045             


Arg Val  Ala Phe Glu Val Ala  Tyr Gln Leu Glu Gln  Ala Gly Glu 
    3050                 3055                 3060             


Glu Val  Asn Ala Leu Asn Leu  Leu Ala Pro Gly Ser  Pro His Leu 
    3065                 3070                 3075             


Asp Met  Lys Gln Ala Glu Tyr  Met Asp Lys Gly Ala  Glu Phe Thr 
    3080                 3085                 3090             


Asn Pro  Ala Phe Val Lys Ile  Leu Phe Ser Val Phe  Ser Arg Ser 
    3095                 3100                 3105             


Ile Asn  Ser Pro Met Val Lys  Thr Cys Leu Glu Gln  Val Asn Ser 
    3110                 3115                 3120             


Glu Thr  Thr Phe Ile Asn Phe  Ile Cys Ser Arg Phe  Lys Asn Leu 
    3125                 3130                 3135             


Glu Pro  Ser Leu Val Lys Arg  Ile Val Arg Ile Val  Thr Leu Thr 
    3140                 3145                 3150             


Tyr Asp  Phe Lys Tyr Ser Ile  Asp Glu Leu Tyr His  Arg His Leu 
    3155                 3160                 3165             


Lys Ala  Pro Ile Thr Ile Phe  Lys Ala Asn Arg Asp  Asn Asp Ser 
    3170                 3175                 3180             


Phe Ile  Glu Glu Ser Asp Val  Ile Ser Ser Met Ser  Pro Lys Ile 
    3185                 3190                 3195             


Ile Glu  Leu Ile Ser Asp His  Tyr Gln Leu Leu Glu  Ser Glu Gly 
    3200                 3205                 3210             


Val Ala  Glu Ile Glu Lys Ile  Ile 
    3215                 3220     


<210>  29
<211>  4256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Indigoidine-tagged Tripeptide consisting 
       of Ornithine and two Valines

<400>  29

Met Leu His Ser Phe Leu Ala Thr Lys Thr Ala Tyr Pro Thr Asp Lys 
1               5                   10                  15      


Thr Phe Gln Lys Leu Phe Glu Glu Gln Val Glu Lys Thr Pro Asn Glu 
            20                  25                  30          


Ile Ala Val Leu Phe Gly Asn Glu Gln Leu Thr Tyr Gln Glu Leu Asn 
        35                  40                  45              


Ala Lys Ala Asn Gln Leu Ala Arg Val Leu Arg Arg Lys Gly Val Lys 
    50                  55                  60                  


Pro Glu Ser Thr Val Gly Ile Leu Val Asp Arg Ser Leu Tyr Met Val 
65                  70                  75                  80  


Ile Gly Met Leu Ala Val Leu Lys Ala Gly Gly Thr Phe Val Pro Ile 
                85                  90                  95      


Asp Pro Asp Tyr Pro Leu Glu Arg Gln Ala Phe Met Leu Glu Asp Ser 
            100                 105                 110         


Glu Ala Lys Leu Leu Leu Thr Leu Gln Lys Met Asn Ser Gln Val Ala 
        115                 120                 125             


Phe Pro Tyr Glu Thr Phe Tyr Leu Asp Thr Glu Thr Val Asp Gln Glu 
    130                 135                 140                 


Glu Thr Gly Asn Leu Glu His Val Ala Gln Pro Glu Asn Val Ala Tyr 
145                 150                 155                 160 


Ile Ile Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Val Val Ile 
                165                 170                 175     


Glu His Arg Ser Tyr Ala Asn Val Ala Phe Ala Trp Lys Asp Glu Tyr 
            180                 185                 190         


His Leu Asp Ser Phe Pro Val Arg Leu Leu Gln Met Ala Ser Phe Ala 
        195                 200                 205             


Phe Asp Val Ser Thr Gly Asp Phe Ala Arg Ala Leu Leu Thr Gly Gly 
    210                 215                 220                 


Gln Leu Val Ile Cys Pro Asn Gly Val Lys Met Asp Pro Ala Ser Leu 
225                 230                 235                 240 


Tyr Glu Thr Ile Arg Arg His Glu Ile Thr Ile Phe Glu Ala Thr Pro 
                245                 250                 255     


Ala Leu Ile Met Pro Leu Met His Tyr Val Tyr Glu Asn Glu Leu Asp 
            260                 265                 270         


Met Ser Gln Met Lys Leu Leu Ile Leu Gly Ala Asp Ser Cys Pro Ala 
        275                 280                 285             


Glu Asp Phe Lys Thr Leu Leu Ala Arg Phe Gly Gln Lys Met Arg Ile 
    290                 295                 300                 


Ile Asn Ser Tyr Gly Val Thr Glu Ala Cys Ile Asp Thr Ser Tyr Tyr 
305                 310                 315                 320 


Glu Glu Thr Asp Val Thr Ala Ile Arg Ser Gly Thr Val Pro Ile Gly 
                325                 330                 335     


Lys Pro Leu Pro Asn Met Thr Met Tyr Val Val Asp Ala His Leu Asn 
            340                 345                 350         


Leu Gln Pro Val Gly Val Val Gly Glu Leu Cys Ile Gly Gly Ala Gly 
        355                 360                 365             


Val Ala Arg Gly Tyr Leu Asn Arg Pro Glu Leu Thr Glu Glu Lys Phe 
    370                 375                 380                 


Val Pro Asn Pro Phe Ala Pro Gly Glu Arg Leu Tyr Arg Thr Gly Asp 
385                 390                 395                 400 


Leu Ala Lys Trp Arg Ala Asp Gly Asn Val Glu Phe Leu Gly Arg Asn 
                405                 410                 415     


Asp His Gln Val Lys Ile Arg Gly Val Arg Ile Glu Leu Gly Glu Ile 
            420                 425                 430         


Glu Thr Gln Leu Arg Lys Leu Asp Gly Ile Thr Glu Ala Val Val Val 
        435                 440                 445             


Ala Arg Glu Asp Arg Gly Gln Glu Lys Glu Leu Cys Ala Tyr Val Val 
    450                 455                 460                 


Ala Asp His Lys Leu Asp Thr Ala Glu Leu Arg Ala Asn Leu Leu Lys 
465                 470                 475                 480 


Glu Leu Pro Gln Ala Met Ile Pro Ala Tyr Phe Val Thr Leu Asp Ala 
                485                 490                 495     


Leu Pro Leu Thr Ala Asn Gly Lys Val Asp Arg Arg Ser Leu Pro Ala 
            500                 505                 510         


Pro Asp Val Thr Met Leu Arg Thr Thr Glu Tyr Val Ala Pro Arg Ser 
        515                 520                 525             


Val Trp Glu Ala Arg Leu Ala Gln Val Trp Glu Gln Val Leu Asn Val 
    530                 535                 540                 


Pro Gln Val Gly Ala Leu Asp Asp Phe Phe Ala Leu Gly Gly His Ser 
545                 550                 555                 560 


Leu Arg Ala Met Arg Val Leu Ser Ser Met His Asn Glu Tyr Gln Val 
                565                 570                 575     


Asp Ile Pro Leu Arg Ile Leu Phe Glu Lys Pro Thr Ile Gln Glu Leu 
            580                 585                 590         


Ala Ala Phe Ile Glu Thr Ser Gly Lys Glu Thr Tyr Val Pro Ile Glu 
        595                 600                 605             


Pro Ala Pro Leu Gln Glu Tyr Tyr Pro Val Ser Ser Ala Gln Lys Arg 
    610                 615                 620                 


Met Tyr Val Leu Arg Gln Phe Ala Asp Thr Gly Thr Val Tyr Asn Met 
625                 630                 635                 640 


Pro Ser Ala Leu Tyr Ile Glu Gly Asp Leu Asp Arg Lys Arg Phe Glu 
                645                 650                 655     


Ala Ala Ile His Gly Leu Val Glu Arg His Glu Ser Leu Arg Thr Ser 
            660                 665                 670         


Phe His Thr Val Asn Gly Glu Pro Val Gln Arg Val His Glu His Val 
        675                 680                 685             


Glu Leu Asn Val Gln Tyr Ala Glu Val Thr Glu Ala Gln Val Glu Pro 
    690                 695                 700                 


Thr Val Glu Ser Phe Val Gln Ala Phe Asp Leu Thr Lys Ala Pro Leu 
705                 710                 715                 720 


Leu Arg Val Gly Leu Phe Lys Leu Ala Ala Lys Arg His Leu Phe Leu 
                725                 730                 735     


Leu Asp Met His His Ile Ile Ser Asp Gly Val Ser Ala Gly Ile Ile 
            740                 745                 750         


Met Glu Glu Phe Ser Lys Leu Tyr Arg Gly Glu Glu Leu Pro Ala Leu 
        755                 760                 765             


Ser Val His Tyr Lys Asp Phe Ala Val Trp Gln Ser Glu Leu Phe Gln 
    770                 775                 780                 


Ser Asp Val Tyr Thr Glu His Glu Asn Tyr Trp Leu Asn Ala Phe Ser 
785                 790                 795                 800 


Gly Asp Ile Pro Val Leu Asn Leu Pro Ala Asp Phe Ser Arg Pro Leu 
                805                 810                 815     


Thr Gln Ser Phe Glu Gly Asp Cys Val Ser Phe Gln Ala Asp Lys Ala 
            820                 825                 830         


Leu Leu Asp Asp Leu His Lys Leu Ala Gln Glu Ser Gln Ser Thr Leu 
        835                 840                 845             


Phe Met Val Leu Leu Ala Ala Tyr Asn Val Leu Leu Ala Lys Tyr Ser 
    850                 855                 860                 


Gly Gln Glu Asp Ile Val Val Gly Thr Pro Ile Ala Gly Arg Ser His 
865                 870                 875                 880 


Ala Asp Ile Glu Asn Val Leu Gly Met Phe Val Asn Thr Leu Ala Leu 
                885                 890                 895     


Arg Asn Tyr Pro Val Glu Thr Lys His Phe Gln Ala Phe Leu Glu Glu 
            900                 905                 910         


Val Lys Gln Asn Thr Leu Gln Ala Tyr Ala His Gln Asp Tyr Pro Phe 
        915                 920                 925             


Glu Ala Leu Val Glu Lys Leu Asp Ile Gln Arg Asp Leu Ser Arg Asn 
    930                 935                 940                 


Pro Leu Phe Asp Thr Met Phe Ile Leu Gln Asn Leu Asp Gln Lys Ala 
945                 950                 955                 960 


Tyr Glu Leu Asp Gly Leu Lys Leu Glu Ala Tyr Pro Ala Gln Ala Gly 
                965                 970                 975     


Asn Ala Lys Phe Asp Leu Thr Leu Glu Ala His Glu Asp Glu Thr Gly 
            980                 985                 990         


Ile His Phe Ala Leu Val Tyr Ser  Thr Lys Leu Phe Gln  Arg Glu Ser 
        995                 1000                 1005             


Ile Glu  Arg Met Ala Gly His  Phe Leu Gln Val Leu  Arg Gln Val 
    1010                 1015                 1020             


Val Ala  Asp Gln Ala Thr Ala  Leu Arg Glu Ile Ser  Leu Leu Ser 
    1025                 1030                 1035             


Glu Glu  Glu Arg Arg Ile Val  Thr Val Asp Phe Asn  Asn Thr Phe 
    1040                 1045                 1050             


Ala Ala  Tyr Pro Arg Asp Leu  Thr Ile Gln Glu Leu  Phe Glu Gln 
    1055                 1060                 1065             


Gln Ala  Ala Lys Thr Pro Glu  His Ala Ala Val Val  Met Asp Gly 
    1070                 1075                 1080             


Gln Met  Leu Thr Tyr Arg Glu  Leu Asn Glu Lys Ala  Asn Gln Leu 
    1085                 1090                 1095             


Ala His  Val Leu Arg Gln Asn  Gly Val Gly Lys Glu  Ser Ile Val 
    1100                 1105                 1110             


Gly Leu  Leu Ala Asp Arg Ser  Leu Glu Met Ile Thr  Gly Ile Met 
    1115                 1120                 1125             


Gly Ile  Leu Lys Ala Gly Gly  Ala Tyr Leu Gly Leu  Asp Pro Glu 
    1130                 1135                 1140             


His Pro  Ser Glu Arg Leu Ala  Tyr Met Leu Glu Asp  Gly Gly Val 
    1145                 1150                 1155             


Lys Val  Val Leu Val Gln Lys  His Leu Leu Pro Leu  Val Gly Glu 
    1160                 1165                 1170             


Gly Leu  Met Pro Ile Val Leu  Glu Glu Glu Ser Leu  Arg Pro Glu 
    1175                 1180                 1185             


Asp Cys  Gly Asn Pro Ala Ile  Val Asn Gly Ala Ser  Asp Leu Ala 
    1190                 1195                 1200             


Tyr Val  Met Tyr Thr Ser Gly  Ser Thr Gly Lys Pro  Lys Gly Val 
    1205                 1210                 1215             


Met Val  Glu His Arg Asn Val  Thr Arg Leu Val Met  His Thr Asn 
    1220                 1225                 1230             


Tyr Val  Gln Val Arg Glu Ser  Asp Arg Met Ile Gln  Thr Gly Ala 
    1235                 1240                 1245             


Ile Gly  Phe Asp Ala Met Thr  Phe Glu Ile Phe Gly  Ala Leu Leu 
    1250                 1255                 1260             


His Gly  Ala Ser Leu Tyr Leu  Val Ser Lys Asp Val  Leu Leu Asp 
    1265                 1270                 1275             


Ala Glu  Lys Leu Gly Asp Phe  Leu Arg Thr Asn Gln  Ile Thr Thr 
    1280                 1285                 1290             


Met Trp  Leu Thr Ser Pro Leu  Phe Asn Gln Leu Ser  Gln Asp Asn 
    1295                 1300                 1305             


Pro Ala  Met Phe Asp Ser Leu  Arg Ala Leu Ile Val  Gly Gly Glu 
    1310                 1315                 1320             


Ala Leu  Ser Pro Lys His Ile  Asn Arg Val Lys Ser  Ala Leu Pro 
    1325                 1330                 1335             


Asp Leu  Glu Ile Trp Asn Gly  Tyr Gly Pro Thr Glu  Asn Thr Thr 
    1340                 1345                 1350             


Phe Ser  Thr Cys Tyr Leu Ile  Glu Gln His Phe Glu  Glu Gln Ile 
    1355                 1360                 1365             


Pro Ile  Gly Lys Pro Ile Ala  Asn Ser Thr Ala Tyr  Ile Val Asp 
    1370                 1375                 1380             


Gly Asn  Asn Gln Pro Gln Pro  Ile Gly Val Pro Gly  Glu Leu Cys 
    1385                 1390                 1395             


Val Gly  Gly Asp Gly Val Ala  Arg Gly Tyr Val Asn  Lys Pro Glu 
    1400                 1405                 1410             


Leu Thr  Ala Glu Lys Phe Val  Pro Asn Pro Phe Ala  Pro Gly Glu 
    1415                 1420                 1425             


Thr Met  Tyr Arg Thr Gly Asp  Leu Ala Arg Trp Leu  Pro Asp Gly 
    1430                 1435                 1440             


Thr Ile  Glu Tyr Leu Gly Arg  Ile Asp Gln Gln Val  Lys Ile Arg 
    1445                 1450                 1455             


Gly Tyr  Arg Ile Glu Leu Gly  Glu Ile Glu Thr Val  Leu Ser Gln 
    1460                 1465                 1470             


Gln Ala  Gln Val Lys Glu Ala  Val Val Ala Val Ile  Glu Glu Ala 
    1475                 1480                 1485             


Asn Gly  Gln Lys Ala Leu Cys  Ala Tyr Phe Val Pro  Glu Gln Ala 
    1490                 1495                 1500             


Val Asp  Ala Ala Glu Leu Arg  Glu Ala Met Ser Lys  Gln Leu Pro 
    1505                 1510                 1515             


Gly Tyr  Met Val Pro Ala Tyr  Tyr Val Gln Met Glu  Lys Leu Pro 
    1520                 1525                 1530             


Leu Thr  Ala Asn Gly Lys Val  Asp Arg Arg Ala Leu  Pro Gln Pro 
    1535                 1540                 1545             


Ser Gly  Glu Arg Thr Thr Gly  Ser Ala Phe Val Ala  Ala Gln Asn 
    1550                 1555                 1560             


Asp Thr  Glu Ala Lys Leu Gln  Gln Ile Trp Gln Glu  Val Leu Gly 
    1565                 1570                 1575             


Ile Pro  Ala Ile Gly Ile His  Asp Asn Phe Phe Glu  Ile Gly Gly 
    1580                 1585                 1590             


His Ser  Leu Lys Ala Met Asn  Val Ile Thr Gln Val  His Lys Thr 
    1595                 1600                 1605             


Phe Gln  Val Glu Leu Pro Leu  Lys Ala Leu Phe Ala  Thr Pro Thr 
    1610                 1615                 1620             


Ile His  Glu Leu Ala Ala His  Ile Ala Thr Ser Gly  Lys Glu Thr 
    1625                 1630                 1635             


Tyr Val  Pro Ile Glu Pro Ala  Pro Leu Gln Glu Tyr  Tyr Pro Val 
    1640                 1645                 1650             


Ser Ser  Ala Gln Lys Arg Met  Tyr Val Leu Arg Gln  Phe Ala Asp 
    1655                 1660                 1665             


Thr Gly  Thr Val Tyr Asn Met  Pro Ser Ala Leu Tyr  Ile Glu Gly 
    1670                 1675                 1680             


Asp Leu  Asp Arg Lys Arg Phe  Glu Ala Ala Ile His  Gly Leu Val 
    1685                 1690                 1695             


Glu Arg  His Glu Ser Leu Arg  Thr Ser Phe His Thr  Val Asn Gly 
    1700                 1705                 1710             


Glu Pro  Val Gln Arg Val His  Glu His Val Glu Leu  Asn Val Gln 
    1715                 1720                 1725             


Tyr Ala  Glu Val Thr Glu Ala  Gln Val Glu Pro Thr  Val Glu Ser 
    1730                 1735                 1740             


Phe Val  Gln Ala Phe Asp Leu  Thr Lys Ala Pro Leu  Leu Arg Val 
    1745                 1750                 1755             


Gly Leu  Phe Lys Leu Ala Ala  Lys Arg His Leu Phe  Leu Leu Asp 
    1760                 1765                 1770             


Met His  His Ile Ile Ser Asp  Gly Val Ser Ala Gly  Ile Ile Met 
    1775                 1780                 1785             


Glu Glu  Phe Ser Lys Leu Tyr  Arg Gly Glu Glu Leu  Pro Ala Leu 
    1790                 1795                 1800             


Ser Val  His Tyr Lys Asp Phe  Ala Val Trp Gln Ser  Glu Leu Phe 
    1805                 1810                 1815             


Gln Ser  Asp Val Tyr Thr Glu  His Glu Asn Tyr Trp  Leu Asn Ala 
    1820                 1825                 1830             


Phe Ser  Gly Asp Ile Pro Val  Leu Asn Leu Pro Ala  Asp Phe Ser 
    1835                 1840                 1845             


Arg Pro  Leu Thr Gln Ser Phe  Glu Gly Asp Cys Val  Ser Phe Gln 
    1850                 1855                 1860             


Ala Asp  Lys Ala Leu Leu Asp  Asp Leu His Lys Leu  Ala Gln Glu 
    1865                 1870                 1875             


Ser Gln  Ser Thr Leu Phe Met  Val Leu Leu Ala Ala  Tyr Asn Val 
    1880                 1885                 1890             


Leu Leu  Ala Lys Tyr Ser Gly  Gln Glu Asp Ile Val  Val Gly Thr 
    1895                 1900                 1905             


Pro Ile  Ala Gly Arg Ser His  Ala Asp Ile Glu Asn  Val Leu Gly 
    1910                 1915                 1920             


Met Phe  Val Asn Thr Leu Ala  Leu Arg Asn Tyr Pro  Val Glu Thr 
    1925                 1930                 1935             


Lys His  Phe Gln Ala Phe Leu  Glu Glu Val Lys Gln  Asn Thr Leu 
    1940                 1945                 1950             


Gln Ala  Tyr Ala His Gln Asp  Tyr Pro Phe Glu Ala  Leu Val Glu 
    1955                 1960                 1965             


Lys Leu  Asp Ile Gln Arg Asp  Leu Ser Arg Asn Pro  Leu Phe Asp 
    1970                 1975                 1980             


Thr Met  Phe Ile Leu Gln Asn  Leu Asp Gln Lys Ala  Tyr Glu Leu 
    1985                 1990                 1995             


Asp Gly  Leu Lys Leu Glu Ala  Tyr Pro Ala Gln Ala  Gly Asn Ala 
    2000                 2005                 2010             


Lys Phe  Asp Leu Thr Leu Glu  Ala His Glu Asp Glu  Thr Gly Ile 
    2015                 2020                 2025             


His Phe  Ala Leu Val Tyr Ser  Thr Lys Leu Phe Gln  Arg Glu Ser 
    2030                 2035                 2040             


Ile Glu  Arg Met Ala Gly His  Phe Leu Gln Val Leu  Arg Gln Val 
    2045                 2050                 2055             


Val Ala  Asp Gln Ala Thr Ala  Leu Arg Glu Ile Ser  Leu Leu Ser 
    2060                 2065                 2070             


Glu Glu  Glu Arg Arg Ile Val  Thr Val Asp Phe Asn  Asn Thr Phe 
    2075                 2080                 2085             


Ala Tyr  Pro Arg Asp Leu Thr  Ile Gln Glu Leu Phe  Glu Gln Gln 
    2090                 2095                 2100             


Ala Ala  Lys Thr Pro Glu His  Ala Ala Val Val Met  Asp Gly Gln 
    2105                 2110                 2115             


Met Leu  Thr Tyr Arg Glu Leu  Asn Glu Lys Ala Asn  Gln Leu Ala 
    2120                 2125                 2130             


His Val  Leu Arg Gln Asn Gly  Val Gly Lys Glu Ser  Ile Val Gly 
    2135                 2140                 2145             


Leu Leu  Ala Asp Arg Ser Leu  Glu Met Ile Thr Gly  Ile Met Gly 
    2150                 2155                 2160             


Ile Leu  Lys Ala Gly Gly Ala  Tyr Leu Gly Leu Asp  Pro Glu His 
    2165                 2170                 2175             


Pro Ser  Glu Arg Leu Ala Tyr  Met Leu Glu Asp Gly  Gly Val Lys 
    2180                 2185                 2190             


Val Val  Leu Val Gln Lys His  Leu Leu Pro Leu Val  Gly Glu Gly 
    2195                 2200                 2205             


Leu Met  Pro Ile Val Leu Glu  Glu Glu Ser Leu Arg  Pro Glu Asp 
    2210                 2215                 2220             


Cys Gly  Asn Pro Ala Ile Val  Asn Gly Ala Ser Asp  Leu Ala Tyr 
    2225                 2230                 2235             


Val Met  Tyr Thr Ser Gly Ser  Thr Gly Lys Pro Lys  Gly Val Met 
    2240                 2245                 2250             


Val Glu  His Arg Asn Val Thr  Arg Leu Val Met His  Thr Asn Tyr 
    2255                 2260                 2265             


Val Gln  Val Arg Glu Ser Asp  Arg Met Ile Gln Thr  Gly Ala Ile 
    2270                 2275                 2280             


Gly Phe  Asp Ala Met Thr Phe  Glu Ile Phe Gly Ala  Leu Leu His 
    2285                 2290                 2295             


Gly Ala  Ser Leu Tyr Leu Val  Ser Lys Asp Val Leu  Leu Asp Ala 
    2300                 2305                 2310             


Glu Lys  Leu Gly Asp Phe Leu  Arg Thr Asn Gln Ile  Thr Thr Met 
    2315                 2320                 2325             


Trp Leu  Thr Ser Pro Leu Phe  Asn Gln Leu Ser Gln  Asp Asn Pro 
    2330                 2335                 2340             


Ala Met  Phe Asp Ser Leu Arg  Ala Leu Ile Val Gly  Gly Glu Ala 
    2345                 2350                 2355             


Leu Ser  Pro Lys His Ile Asn  Arg Val Lys Ser Ala  Leu Pro Asp 
    2360                 2365                 2370             


Leu Glu  Ile Trp Asn Gly Tyr  Gly Pro Thr Glu Asn  Thr Thr Phe 
    2375                 2380                 2385             


Ser Thr  Cys Tyr Leu Ile Glu  Gln His Phe Glu Glu  Gln Ile Pro 
    2390                 2395                 2400             


Ile Gly  Lys Pro Ile Ala Asn  Ser Thr Ala Tyr Ile  Val Asp Gly 
    2405                 2410                 2415             


Asn Asn  Gln Pro Gln Pro Ile  Gly Val Pro Gly Glu  Leu Cys Val 
    2420                 2425                 2430             


Gly Gly  Asp Gly Val Ala Arg  Gly Tyr Val Asn Lys  Pro Glu Leu 
    2435                 2440                 2445             


Thr Ala  Glu Lys Phe Val Pro  Asn Pro Phe Ala Pro  Gly Glu Thr 
    2450                 2455                 2460             


Met Tyr  Arg Thr Gly Asp Leu  Ala Arg Trp Leu Pro  Asp Gly Thr 
    2465                 2470                 2475             


Ile Glu  Tyr Leu Gly Arg Ile  Asp Gln Gln Val Lys  Ile Arg Gly 
    2480                 2485                 2490             


Tyr Arg  Ile Glu Leu Gly Glu  Ile Glu Thr Val Leu  Ser Gln Gln 
    2495                 2500                 2505             


Ala Gln  Val Lys Glu Ala Val  Val Ala Val Ile Glu  Glu Ala Asn 
    2510                 2515                 2520             


Gly Gln  Lys Ala Leu Cys Ala  Tyr Phe Val Pro Glu  Gln Ala Val 
    2525                 2530                 2535             


Asp Ala  Ala Glu Leu Arg Glu  Ala Met Ser Lys Gln  Leu Pro Gly 
    2540                 2545                 2550             


Tyr Met  Val Pro Ala Tyr Tyr  Val Gln Met Glu Lys  Leu Pro Leu 
    2555                 2560                 2565             


Thr Ala  Asn Gly Lys Val Asp  Arg Arg Ala Leu Pro  Gln Pro Ser 
    2570                 2575                 2580             


Gly Glu  Arg Thr Thr Gly Ser  Ala Phe Val Ala Ala  Gln Asn Asp 
    2585                 2590                 2595             


Thr Glu  Ala Lys Leu Gln Gln  Ile Trp Gln Glu Val  Leu Gly Ile 
    2600                 2605                 2610             


Pro Ala  Ile Gly Ile His Asp  Asn Phe Phe Glu Ile  Gly Gly His 
    2615                 2620                 2625             


Ser Leu  Lys Ala Met Asn Val  Ile Thr Gln Val His  Lys Thr Phe 
    2630                 2635                 2640             


Gln Val  Glu Leu Pro Leu Lys  Ala Leu Phe Ala Thr  Pro Thr Ile 
    2645                 2650                 2655             


His Glu  Leu Ala Ala His Ile  Ser Glu Lys Thr Glu  Tyr Thr Ala 
    2660                 2665                 2670             


Ile Gln  Pro Val Ala Ala Gln  Glu Phe Tyr Pro Val  Ser Ser Ala 
    2675                 2680                 2685             


Gln Lys  Arg Met Tyr Ile Leu  Gln Gln Phe Glu Gly  Asn Gly Ile 
    2690                 2695                 2700             


Ser Tyr  Asn Ile Ser Gly Ala  Ile Leu Leu Glu Gly  Lys Leu Asp 
    2705                 2710                 2715             


Tyr Ala  Arg Phe Ala Ser Ala  Val Gln Gln Leu Ala  Glu Arg His 
    2720                 2725                 2730             


Glu Ala  Leu Arg Thr Ser Phe  His Arg Ile Asp Gly  Glu Pro Val 
    2735                 2740                 2745             


Gln Lys  Val His Glu Glu Val  Glu Val Pro Leu Phe  Met Leu Glu 
    2750                 2755                 2760             


Ala Pro  Glu Asp Gln Ala Glu  Lys Ile Met Arg Glu  Phe Val Arg 
    2765                 2770                 2775             


Pro Phe  Asp Leu Gly Val Ala  Pro Leu Met Arg Thr  Gly Leu Leu 
    2780                 2785                 2790             


Lys Leu  Gly Lys Asp Arg His  Leu Phe Leu Leu Asp  Met His His 
    2795                 2800                 2805             


Ile Ile  Ser Asp Gly Val Ser  Ser Gln Ile Leu Leu  Arg Glu Phe 
    2810                 2815                 2820             


Ala Glu  Leu Tyr Gln Gly Ala  Asp Leu Gln Pro Leu  Ser Leu Gln 
    2825                 2830                 2835             


Tyr Lys  Asp Phe Ala Ala Trp  Gln Asn Glu Leu Phe  Gln Thr Glu 
    2840                 2845                 2850             


Ala Tyr  Lys Lys Gln Glu Gln  His Trp Leu Asn Thr  Phe Ala Asp 
    2855                 2860                 2865             


Glu Ile  Pro Leu Leu Asn Leu  Pro Thr Asp Tyr Pro  Arg Pro Ser 
    2870                 2875                 2880             


Val Gln  Ser Phe Ala Gly Asp  Leu Val Leu Phe Ala  Ala Gly Lys 
    2885                 2890                 2895             


Glu Leu  Leu Glu Arg Leu Gln  Gln Val Ala Ser Glu  Thr Gly Thr 
    2900                 2905                 2910             


Thr Leu  Tyr Met Ile Leu Leu  Ala Ala Tyr Asn Val  Leu Leu Ser 
    2915                 2920                 2925             


Lys Tyr  Thr Gly Gln Glu Asp  Ile Ile Val Gly Thr  Pro Val Ala 
    2930                 2935                 2940             


Gly Arg  Ser His Ala Asp Val  Glu Asn Ile Met Gly  Ile Phe Val 
    2945                 2950                 2955             


Asn Thr  Leu Ala Leu Arg Asn  Gln Pro Ala Ser Ser  Lys Thr Met 
    2960                 2965                 2970             


Leu Glu  Asn Asn Ile Thr Gln  Cys Asp Ser Ile Asn  Asp Val Tyr 
    2975                 2980                 2985             


Leu Lys  Glu Glu Ala Ile Thr  Leu Met Asp Met Leu  Glu Ser Gln 
    2990                 2995                 3000             


Leu Lys  His Gln Ala Asp Gly  Tyr Val Val Ile Asp  Gln Glu Glu 
    3005                 3010                 3015             


Ser Leu  Ser Tyr Ala Asp Phe  Tyr Leu Arg Val Lys  Glu Ile Gly 
    3020                 3025                 3030             


Tyr Cys  Leu Ser Glu Ile Ser  Ser Lys Asn Ser Val  Gly Ile Gly 
    3035                 3040                 3045             


Leu Phe  Cys Asp Pro Ser Ile  Asp Leu Ile Cys Gly  Ala Trp Gly 
    3050                 3055                 3060             


Ile Leu  Ser Ala Asp Lys Ala  Tyr Leu Pro Leu Ser  Pro Asp Tyr 
    3065                 3070                 3075             


Pro Thr  Glu Arg Leu Lys Tyr  Met Ile Glu Asp Ser  Gly Ile Asp 
    3080                 3085                 3090             


Val Ile  Phe Thr Gln Ser His  Leu Lys Ala Gln Leu  Gln Asp Ile 
    3095                 3100                 3105             


Ala Pro  Lys Ser Val Leu Ile  Met Thr Pro Glu Asp  Val Ala Leu 
    3110                 3115                 3120             


Thr Ile  Lys Thr Arg Thr Ile  Glu Asp Ile Leu Gly  Thr Val Gln 
    3125                 3130                 3135             


Val Pro  Lys Pro Thr Ser Leu  Ala Tyr Ile Ile Tyr  Thr Ser Gly 
    3140                 3145                 3150             


Ser Thr  Gly Lys Pro Lys Gly  Val Met Ile Glu His  His Ser Ile 
    3155                 3160                 3165             


Val Asn  Gln Met Arg Phe Leu  Ala Lys Ala Phe Lys  Leu Gly Cys 
    3170                 3175                 3180             


His Ser  Arg Ile Leu Gln Lys  Thr Pro Met Ser Phe  Asp Ala Ala 
    3185                 3190                 3195             


Gln Trp  Glu Ile Leu Ala Pro  Ala Ile Gly Gly Gln  Val Ile Met 
    3200                 3205                 3210             


Gly Pro  Leu Gly Cys Tyr Arg  Asp Pro Asp Ala Ile  Ile Lys Thr 
    3215                 3220                 3225             


Ile Leu  Gln His Gln Val Thr  Thr Leu Gln Cys Val  Pro Thr Leu 
    3230                 3235                 3240             


Leu Gln  Ala Leu Leu Asp Asn  Pro Asn Phe Leu Asp  Cys Leu Ser 
    3245                 3250                 3255             


Leu Thr  Gln Val Phe Ser Gly  Gly Glu Ala Leu Thr  Thr Lys Leu 
    3260                 3265                 3270             


Ala Thr  Gln Phe Leu Asn Ser  Phe Thr His Cys Glu  Leu Ile Asn 
    3275                 3280                 3285             


Leu Tyr  Gly Pro Thr Glu Cys  Thr Ile Asn Ser Ser  Phe Phe Arg 
    3290                 3295                 3300             


Val Thr  Asn Glu Thr Leu Pro  Asn Tyr Gln Thr Ser  Ile Ser Ile 
    3305                 3310                 3315             


Gly Ala  Pro Val Asp Asn Thr  Glu Tyr Tyr Val Leu  Asp Asp Asp 
    3320                 3325                 3330             


Arg Leu  Pro Val Ala Val Gly  Glu Ile Gly Glu Leu  Tyr Ile Ser 
    3335                 3340                 3345             


Gly Ala  Gln Leu Ala Arg Gly  Tyr Leu His Lys Pro  Glu Met Thr 
    3350                 3355                 3360             


Lys Asp  Lys Phe Ile Cys Asn  His Leu Val Ser Gly  Thr Gln His 
    3365                 3370                 3375             


Gln Trp  Leu Tyr Arg Thr Gly  Asp Leu Val Thr Arg  Gly Ala Asp 
    3380                 3385                 3390             


Gly Asn  Thr Tyr Phe Val Gly  Arg Val Asp Ser Gln  Val Lys Leu 
    3395                 3400                 3405             


Arg Gly  Tyr Arg Ile Glu Leu  Asp Glu Ile Arg His  Ala Ile Glu 
    3410                 3415                 3420             


Glu His  Ser Trp Ile Lys Thr  Ala Ala Met Leu Ile  Lys Lys Asp 
    3425                 3430                 3435             


Ala Arg  Thr Gly Phe Gln Asn  Leu Ile Ala Cys Val  Glu Leu Asp 
    3440                 3445                 3450             


Glu Lys  Glu Ala Ala Leu Met  Asp Gln Gly Asn Ser  Ser Ser His 
    3455                 3460                 3465             


His Lys  Ser Lys Ala Asp Lys  Leu Gln Val Lys Ala  Gln Leu Ser 
    3470                 3475                 3480             


Asn Ser  Gly Cys Arg Ser Glu  Glu Leu Cys Glu Asn  Arg Pro Thr 
    3485                 3490                 3495             


Phe Leu  Leu Pro Tyr Gln Glu  Gly Glu Ile Lys Gln  Arg Glu Tyr 
    3500                 3505                 3510             


Ala Phe  Gly Arg Lys Thr Tyr  Arg Tyr Phe Glu Gly  Thr Glu Ile 
    3515                 3520                 3525             


Thr Val  Glu Lys Leu Lys Lys  Leu Leu Thr Ala Thr  Gln Ser Asn 
    3530                 3535                 3540             


Glu Ile  Ser Ser Leu Pro Leu  Ser His Leu Thr Leu  Asn Asp Phe 
    3545                 3550                 3555             


Gly Tyr  Ala Leu Arg Tyr Phe  Gly Gln Phe Thr Ser  His Gln Arg 
    3560                 3565                 3570             


Leu Leu  Pro Lys Tyr Ala Tyr  Ala Ser Pro Gly Ala  Leu Tyr Ala 
    3575                 3580                 3585             


Thr Gln  Met Tyr Phe Glu Leu  His Asn Val Leu Gly  Leu Asp Ala 
    3590                 3595                 3600             


Gly Ile  Tyr Tyr Tyr His Pro  Val Thr His Lys Leu  Ile Lys Ile 
    3605                 3610                 3615             


Ser Thr  Leu Ser Arg Arg Gln  Met Pro Thr Ile Lys  Val His Phe 
    3620                 3625                 3630             


Ile Gly  Lys His Glu Ala Ile  Glu Pro Val Tyr Lys  Asn Asn Ile 
    3635                 3640                 3645             


Gln Glu  Val Leu Glu Met Glu  Ala Gly His Met Met  Gly Leu Phe 
    3650                 3655                 3660             


Asp Asp  Val Leu Pro Glu Ile  Gly Leu Ser Ile Gly  Lys Ser Glu 
    3665                 3670                 3675             


Tyr Gln  Asp Glu Cys Pro Asp  Trp Tyr Asp Gly Asp  Ile Gln Asp 
    3680                 3685                 3690             


Tyr Tyr  Leu Gly Ala Phe Glu  Ile Cys Ser Tyr Glu  His Gly Leu 
    3695                 3700                 3705             


Pro Pro  Phe Glu Thr Asp Ile  Tyr Leu Gln Thr His  Ala His Lys 
    3710                 3715                 3720             


Ile Pro  Glu Met Pro Cys Gly  Leu Tyr His Phe Ser  Asn Gly Glu 
    3725                 3730                 3735             


Phe Val  Arg Ile Ser Asp Asp  Ile Val Arg Lys Lys  Asp Val Ile 
    3740                 3745                 3750             


Ala Ile  Asn Gln Gln Val Tyr  Asp Arg Ser Ser Phe  Gly Val Ser 
    3755                 3760                 3765             


Ile Ile  Pro Arg Cys Val Pro  Glu Trp His Tyr Tyr  Ile Thr Leu 
    3770                 3775                 3780             


Gly Arg  Arg Leu His Ala Leu  Gln Ser Asn Pro Leu  Tyr Ile Gly 
    3785                 3790                 3795             


Leu Met  Ser Ser Gly Tyr Ser  Ser Lys Ser Asn Asn  Asp Leu Pro 
    3800                 3805                 3810             


Ser Ala  Lys Arg Met Arg Ser  Ile Leu Asn Ala Leu  Asp Arg Pro 
    3815                 3820                 3825             


Met Ala  Ala Phe Tyr Phe Cys  Ile Gly Gly Gly Ile  Ser Gln Ala 
    3830                 3835                 3840             


Gln Tyr  Met Cys Glu Gly Met  Lys Glu Asp Val Val  His Met Lys 
    3845                 3850                 3855             


Gly Pro  Val Glu Ile Ile Lys  Asp Asp Leu Gln Gln  Gln Leu Pro 
    3860                 3865                 3870             


Gln Tyr  Met Ile Pro Asn Lys  Val Leu Val Phe Asp  Lys Leu Pro 
    3875                 3880                 3885             


Leu Thr  Ala Asn Gly Lys Val  Asp Tyr Gln Ser Leu  Ser Glu Ser 
    3890                 3895                 3900             


Lys Ala  Val Glu Asn Val Ser  Thr Gln Arg Leu Leu  Val Pro Leu 
    3905                 3910                 3915             


His Thr  Asp Thr Glu Ile Arg  Leu Gly Lys Ile Trp  Met Glu Val 
    3920                 3925                 3930             


Leu Lys  Trp Asp Ser Val Ser  Ala Leu Asp Asp Phe  Phe Glu Ser 
    3935                 3940                 3945             


Gly Gly  Asn Ser Leu Met Ala  Val Ala Met Val Asn  Lys Ile Asn 
    3950                 3955                 3960             


Ala Ala  Phe Asn Ile Arg Phe  Pro Leu Gln Ile Leu  Phe Gln Ser 
    3965                 3970                 3975             


Pro Asn  Ile Ala Glu Leu Ala  Lys Trp Ile Glu Gln  Thr Asp Ser 
    3980                 3985                 3990             


Lys Thr  Ile Ser Arg Leu Ile  Leu Leu Asn Gln Ala  Ser Lys Asp 
    3995                 4000                 4005             


Pro Ile  Tyr Cys Trp Pro Gly  Leu Gly Gly Tyr Pro  Met Ser Leu 
    4010                 4015                 4020             


Arg Leu  Leu Ala Asn Lys Val  Val Pro Asp Arg Ala  Phe Tyr Gly 
    4025                 4030                 4035             


Ile Gln  Ala Tyr Gly Ile Asn  Glu Ser Glu Ile Pro  Phe Ser Ser 
    4040                 4045                 4050             


Ile Gln  Arg Met Ala Glu Glu  Asp Ile Lys Glu Ile  Lys Lys Ile 
    4055                 4060                 4065             


Gln Pro  Glu Gly Pro Tyr Ile  Leu Trp Gly Tyr Ser  Phe Gly Ala 
    4070                 4075                 4080             


Arg Val  Ala Phe Glu Val Ala  Tyr Gln Leu Glu Gln  Ala Gly Glu 
    4085                 4090                 4095             


Glu Val  Asn Ala Leu Asn Leu  Leu Ala Pro Gly Ser  Pro His Leu 
    4100                 4105                 4110             


Asp Met  Lys Gln Ala Glu Tyr  Met Asp Lys Gly Ala  Glu Phe Thr 
    4115                 4120                 4125             


Asn Pro  Ala Phe Val Lys Ile  Leu Phe Ser Val Phe  Ser Arg Ser 
    4130                 4135                 4140             


Ile Asn  Ser Pro Met Val Lys  Thr Cys Leu Glu Gln  Val Asn Ser 
    4145                 4150                 4155             


Glu Thr  Thr Phe Ile Asn Phe  Ile Cys Ser Arg Phe  Lys Asn Leu 
    4160                 4165                 4170             


Glu Pro  Ser Leu Val Lys Arg  Ile Val Arg Ile Val  Thr Leu Thr 
    4175                 4180                 4185             


Tyr Asp  Phe Lys Tyr Ser Ile  Asp Glu Leu Tyr His  Arg His Leu 
    4190                 4195                 4200             


Lys Ala  Pro Ile Thr Ile Phe  Lys Ala Asn Arg Asp  Asn Asp Ser 
    4205                 4210                 4215             


Phe Ile  Glu Glu Ser Asp Val  Ile Ser Ser Met Ser  Pro Lys Ile 
    4220                 4225                 4230             


Ile Glu  Leu Ile Ser Asp His  Tyr Gln Leu Leu Glu  Ser Glu Gly 
    4235                 4240                 4245             


Val Ala  Glu Ile Glu Lys Ile  Ile 
    4250                 4255     


<210>  30
<211>  2194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase of a fusion peptide consisting of Phenylalanine and 
       Indigoidine

<400>  30

Met Leu Ala Asn Gln Ala Asn Leu Ile Asp Asn Lys Arg Glu Leu Glu 
1               5                   10                  15      


Gln His Ala Leu Val Pro Tyr Ala Gln Gly Lys Ser Ile His Gln Leu 
            20                  25                  30          


Phe Glu Glu Gln Ala Glu Ala Phe Pro Asp Arg Val Ala Ile Val Phe 
        35                  40                  45              


Glu Asn Arg Arg Leu Ser Tyr Gln Glu Leu Asn Arg Lys Ala Asn Gln 
    50                  55                  60                  


Leu Ala Arg Ala Leu Leu Glu Lys Gly Val Gln Thr Asp Ser Ile Val 
65                  70                  75                  80  


Gly Val Met Met Glu Lys Ser Ile Glu Asn Val Ile Ala Ile Leu Ala 
                85                  90                  95      


Val Leu Lys Ala Gly Gly Ala Tyr Val Pro Ile Asp Ile Glu Tyr Pro 
            100                 105                 110         


Arg Asp Arg Ile Gln Tyr Ile Leu Gln Asp Ser Gln Thr Lys Ile Val 
        115                 120                 125             


Leu Thr Gln Lys Ser Val Ser Gln Leu Val His Asp Val Gly Tyr Ser 
    130                 135                 140                 


Gly Glu Val Val Val Leu Asp Glu Glu Gln Leu Asp Ala Arg Glu Thr 
145                 150                 155                 160 


Ala Asn Leu His Gln Pro Ser Lys Pro Thr Asp Leu Ala Tyr Val Ile 
                165                 170                 175     


Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Thr Met Leu Glu His 
            180                 185                 190         


Lys Gly Ile Ala Asn Leu Gln Ser Phe Phe Gln Asn Ser Phe Gly Val 
        195                 200                 205             


Thr Glu Gln Asp Arg Ile Gly Leu Phe Ala Ser Met Ser Phe Asp Ala 
    210                 215                 220                 


Ser Val Trp Glu Met Phe Met Ala Leu Leu Ser Gly Ala Ser Leu Tyr 
225                 230                 235                 240 


Ile Leu Ser Lys Gln Thr Ile His Asp Phe Ala Ala Phe Glu His Tyr 
                245                 250                 255     


Leu Ser Glu Asn Glu Leu Thr Ile Ile Thr Leu Pro Pro Thr Tyr Leu 
            260                 265                 270         


Thr His Leu Thr Pro Glu Arg Ile Thr Ser Leu Arg Ile Met Ile Thr 
        275                 280                 285             


Ala Gly Ser Ala Ser Ser Ala Pro Leu Val Asn Lys Trp Lys Asp Lys 
    290                 295                 300                 


Leu Arg Tyr Ile Asn Ala Tyr Gly Pro Thr Glu Thr Ser Ile Cys Ala 
305                 310                 315                 320 


Thr Ile Trp Glu Ala Pro Ser Asn Gln Leu Ser Val Gln Ser Val Pro 
                325                 330                 335     


Ile Gly Lys Pro Ile Gln Asn Thr His Ile Tyr Ile Val Asn Glu Asp 
            340                 345                 350         


Leu Gln Leu Leu Pro Thr Gly Ser Glu Gly Glu Leu Cys Ile Gly Gly 
        355                 360                 365             


Val Gly Leu Ala Arg Gly Tyr Trp Asn Arg Pro Asp Leu Thr Ala Glu 
    370                 375                 380                 


Lys Phe Val Asp Asn Pro Phe Val Pro Gly Glu Lys Met Tyr Arg Thr 
385                 390                 395                 400 


Gly Asp Leu Ala Lys Trp Leu Thr Asp Gly Thr Ile Glu Phe Leu Gly 
                405                 410                 415     


Arg Ile Asp His Gln Val Lys Ile Arg Gly His Arg Ile Glu Leu Gly 
            420                 425                 430         


Glu Ile Glu Ser Val Leu Leu Ala His Glu His Ile Thr Glu Ala Val 
        435                 440                 445             


Val Ile Ala Arg Glu Asp Gln His Ala Gly Gln Tyr Leu Cys Ala Tyr 
    450                 455                 460                 


Tyr Ile Ser Gln Gln Glu Ala Thr Pro Ala Gln Leu Arg Asp Tyr Ala 
465                 470                 475                 480 


Ala Gln Lys Leu Pro Ala Tyr Met Leu Pro Ser Tyr Phe Val Lys Leu 
                485                 490                 495     


Asp Lys Met Pro Leu Thr Pro Asn Asp Lys Ile Asp Arg Lys Ala Leu 
            500                 505                 510         


Pro Glu Pro Asp Leu Thr Ala Asn Gln Ser Gln Ala Ala Tyr His Pro 
        515                 520                 525             


Pro Arg Thr Glu Thr Glu Ser Ile Leu Val Ser Ile Trp Gln Asn Val 
    530                 535                 540                 


Leu Gly Ile Glu Lys Ile Gly Ile Arg Asp Asn Phe Tyr Ser Leu Gly 
545                 550                 555                 560 


Gly Asp Ser Ile Gln Ala Ile Gln Val Val Ala Arg Leu His Ser Tyr 
                565                 570                 575     


Gln Leu Lys Leu Glu Thr Lys Asp Leu Leu Asn Tyr Pro Thr Ile Glu 
            580                 585                 590         


Gln Val Ala Glu Leu Ala Arg Phe Leu Ser Arg Ser Glu Lys Thr Glu 
        595                 600                 605             


Tyr Thr Ala Ile Gln Pro Val Ala Ala Gln Glu Phe Tyr Pro Val Ser 
    610                 615                 620                 


Ser Ala Gln Lys Arg Met Tyr Ile Leu Gln Gln Phe Glu Gly Asn Gly 
625                 630                 635                 640 


Ile Ser Tyr Asn Ile Ser Gly Ala Ile Leu Leu Glu Gly Lys Leu Asp 
                645                 650                 655     


Tyr Ala Arg Phe Ala Ser Ala Val Gln Gln Leu Ala Glu Arg His Glu 
            660                 665                 670         


Ala Leu Arg Thr Ser Phe His Arg Ile Asp Gly Glu Pro Val Gln Lys 
        675                 680                 685             


Val His Glu Glu Val Glu Val Pro Leu Phe Met Leu Glu Ala Pro Glu 
    690                 695                 700                 


Asp Gln Ala Glu Lys Ile Met Arg Glu Phe Val Arg Pro Phe Asp Leu 
705                 710                 715                 720 


Gly Val Ala Pro Leu Met Arg Thr Gly Leu Leu Lys Leu Gly Lys Asp 
                725                 730                 735     


Arg His Leu Phe Leu Leu Asp Met His His Ile Ile Ser Asp Gly Val 
            740                 745                 750         


Ser Ser Gln Ile Leu Leu Arg Glu Phe Ala Glu Leu Tyr Gln Gly Ala 
        755                 760                 765             


Asp Leu Gln Pro Leu Ser Leu Gln Tyr Lys Asp Phe Ala Ala Trp Gln 
    770                 775                 780                 


Asn Glu Leu Phe Gln Thr Glu Ala Tyr Lys Lys Gln Glu Gln His Trp 
785                 790                 795                 800 


Leu Asn Thr Phe Ala Asp Glu Ile Pro Leu Leu Asn Leu Pro Thr Asp 
                805                 810                 815     


Tyr Pro Arg Pro Ser Val Gln Ser Phe Ala Gly Asp Leu Val Leu Phe 
            820                 825                 830         


Ala Ala Gly Lys Glu Leu Leu Glu Arg Leu Gln Gln Val Ala Ser Glu 
        835                 840                 845             


Thr Gly Thr Thr Leu Tyr Met Ile Leu Leu Ala Ala Tyr Asn Val Leu 
    850                 855                 860                 


Leu Ser Lys Tyr Thr Gly Gln Glu Asp Ile Ile Val Gly Thr Pro Val 
865                 870                 875                 880 


Ala Gly Arg Ser His Ala Asp Val Glu Asn Ile Met Gly Ile Phe Val 
                885                 890                 895     


Asn Thr Leu Ala Leu Arg Asn Gln Pro Ala Ser Ser Lys Thr Met Leu 
            900                 905                 910         


Glu Asn Asn Ile Thr Gln Cys Asp Ser Ile Asn Asp Val Tyr Leu Lys 
        915                 920                 925             


Glu Glu Ala Ile Thr Leu Met Asp Met Leu Glu Ser Gln Leu Lys His 
    930                 935                 940                 


Gln Ala Asp Gly Tyr Val Val Ile Asp Gln Glu Glu Ser Leu Ser Tyr 
945                 950                 955                 960 


Ala Asp Phe Tyr Leu Arg Val Lys Glu Ile Gly Tyr Cys Leu Ser Glu 
                965                 970                 975     


Ile Ser Ser Lys Asn Ser Val Gly Ile Gly Leu Phe Cys Asp Pro Ser 
            980                 985                 990         


Ile Asp Leu Ile Cys Gly Ala Trp  Gly Ile Leu Ser Ala  Asp Lys Ala 
        995                 1000                 1005             


Tyr Leu  Pro Leu Ser Pro Asp  Tyr Pro Thr Glu Arg  Leu Lys Tyr 
    1010                 1015                 1020             


Met Ile  Glu Asp Ser Gly Ile  Asp Val Ile Phe Thr  Gln Ser His 
    1025                 1030                 1035             


Leu Lys  Ala Gln Leu Gln Asp  Ile Ala Pro Lys Ser  Val Leu Ile 
    1040                 1045                 1050             


Met Thr  Pro Glu Asp Val Ala  Leu Thr Ile Lys Thr  Arg Thr Ile 
    1055                 1060                 1065             


Glu Asp  Ile Leu Gly Thr Val  Gln Val Pro Lys Pro  Thr Ser Leu 
    1070                 1075                 1080             


Ala Tyr  Ile Ile Tyr Thr Ser  Gly Ser Thr Gly Lys  Pro Lys Gly 
    1085                 1090                 1095             


Val Met  Ile Glu His His Ser  Ile Val Asn Gln Met  Arg Phe Leu 
    1100                 1105                 1110             


Ala Lys  Ala Phe Lys Leu Gly  Cys His Ser Arg Ile  Leu Gln Lys 
    1115                 1120                 1125             


Thr Pro  Met Ser Phe Asp Ala  Ala Gln Trp Glu Ile  Leu Ala Pro 
    1130                 1135                 1140             


Ala Ile  Gly Gly Gln Val Ile  Met Gly Pro Leu Gly  Cys Tyr Arg 
    1145                 1150                 1155             


Asp Pro  Asp Ala Ile Ile Lys  Thr Ile Leu Gln His  Gln Val Thr 
    1160                 1165                 1170             


Thr Leu  Gln Cys Val Pro Thr  Leu Leu Gln Ala Leu  Leu Asp Asn 
    1175                 1180                 1185             


Pro Asn  Phe Leu Asp Cys Leu  Ser Leu Thr Gln Val  Phe Ser Gly 
    1190                 1195                 1200             


Gly Glu  Ala Leu Thr Thr Lys  Leu Ala Thr Gln Phe  Leu Asn Ser 
    1205                 1210                 1215             


Phe Thr  His Cys Glu Leu Ile  Asn Leu Tyr Gly Pro  Thr Glu Cys 
    1220                 1225                 1230             


Thr Ile  Asn Ser Ser Phe Phe  Arg Val Thr Asn Glu  Thr Leu Pro 
    1235                 1240                 1245             


Asn Tyr  Gln Thr Ser Ile Ser  Ile Gly Ala Pro Val  Asp Asn Thr 
    1250                 1255                 1260             


Glu Tyr  Tyr Val Leu Asp Asp  Asp Arg Leu Pro Val  Ala Val Gly 
    1265                 1270                 1275             


Glu Ile  Gly Glu Leu Tyr Ile  Ser Gly Ala Gln Leu  Ala Arg Gly 
    1280                 1285                 1290             


Tyr Leu  His Lys Pro Glu Met  Thr Lys Asp Lys Phe  Ile Cys Asn 
    1295                 1300                 1305             


His Leu  Val Ser Gly Thr Gln  His Gln Trp Leu Tyr  Arg Thr Gly 
    1310                 1315                 1320             


Asp Leu  Val Thr Arg Gly Ala  Asp Gly Asn Thr Tyr  Phe Val Gly 
    1325                 1330                 1335             


Arg Val  Asp Ser Gln Val Lys  Leu Arg Gly Tyr Arg  Ile Glu Leu 
    1340                 1345                 1350             


Asp Glu  Ile Arg His Ala Ile  Glu Glu His Ser Trp  Ile Lys Thr 
    1355                 1360                 1365             


Ala Ala  Met Leu Ile Lys Lys  Asp Ala Arg Thr Gly  Phe Gln Asn 
    1370                 1375                 1380             


Leu Ile  Ala Cys Val Glu Leu  Asp Glu Lys Glu Ala  Ala Leu Met 
    1385                 1390                 1395             


Asp Gln  Gly Asn Ser Ser Ser  His His Lys Ser Lys  Ala Asp Lys 
    1400                 1405                 1410             


Leu Gln  Val Lys Ala Gln Leu  Ser Asn Ser Gly Cys  Arg Ser Glu 
    1415                 1420                 1425             


Glu Leu  Cys Glu Asn Arg Pro  Thr Phe Leu Leu Pro  Tyr Gln Glu 
    1430                 1435                 1440             


Gly Glu  Ile Lys Gln Arg Glu  Tyr Ala Phe Gly Arg  Lys Thr Tyr 
    1445                 1450                 1455             


Arg Tyr  Phe Glu Gly Thr Glu  Ile Thr Val Glu Lys  Leu Lys Lys 
    1460                 1465                 1470             


Leu Leu  Thr Ala Thr Gln Ser  Asn Glu Ile Ser Ser  Leu Pro Leu 
    1475                 1480                 1485             


Ser His  Leu Thr Leu Asn Asp  Phe Gly Tyr Ala Leu  Arg Tyr Phe 
    1490                 1495                 1500             


Gly Gln  Phe Thr Ser His Gln  Arg Leu Leu Pro Lys  Tyr Ala Tyr 
    1505                 1510                 1515             


Ala Ser  Pro Gly Ala Leu Tyr  Ala Thr Gln Met Tyr  Phe Glu Leu 
    1520                 1525                 1530             


His Asn  Val Leu Gly Leu Asp  Ala Gly Ile Tyr Tyr  Tyr His Pro 
    1535                 1540                 1545             


Val Thr  His Lys Leu Ile Lys  Ile Ser Thr Leu Ser  Arg Arg Gln 
    1550                 1555                 1560             


Met Pro  Thr Ile Lys Val His  Phe Ile Gly Lys His  Glu Ala Ile 
    1565                 1570                 1575             


Glu Pro  Val Tyr Lys Asn Asn  Ile Gln Glu Val Leu  Glu Met Glu 
    1580                 1585                 1590             


Ala Gly  His Met Met Gly Leu  Phe Asp Asp Val Leu  Pro Glu Ile 
    1595                 1600                 1605             


Gly Leu  Ser Ile Gly Lys Ser  Glu Tyr Gln Asp Glu  Cys Pro Asp 
    1610                 1615                 1620             


Trp Tyr  Asp Gly Asp Ile Gln  Asp Tyr Tyr Leu Gly  Ala Phe Glu 
    1625                 1630                 1635             


Ile Cys  Ser Tyr Glu His Gly  Leu Pro Pro Phe Glu  Thr Asp Ile 
    1640                 1645                 1650             


Tyr Leu  Gln Thr His Ala His  Lys Ile Pro Glu Met  Pro Cys Gly 
    1655                 1660                 1665             


Leu Tyr  His Phe Ser Asn Gly  Glu Phe Val Arg Ile  Ser Asp Asp 
    1670                 1675                 1680             


Ile Val  Arg Lys Lys Asp Val  Ile Ala Ile Asn Gln  Gln Val Tyr 
    1685                 1690                 1695             


Asp Arg  Ser Ser Phe Gly Val  Ser Ile Ile Pro Arg  Cys Val Pro 
    1700                 1705                 1710             


Glu Trp  His Tyr Tyr Ile Thr  Leu Gly Arg Arg Leu  His Ala Leu 
    1715                 1720                 1725             


Gln Ser  Asn Pro Leu Tyr Ile  Gly Leu Met Ser Ser  Gly Tyr Ser 
    1730                 1735                 1740             


Ser Lys  Ser Asn Asn Asp Leu  Pro Ser Ala Lys Arg  Met Arg Ser 
    1745                 1750                 1755             


Ile Leu  Asn Ala Leu Asp Arg  Pro Met Ala Ala Phe  Tyr Phe Cys 
    1760                 1765                 1770             


Ile Gly  Gly Gly Ile Ser Gln  Ala Gln Tyr Met Cys  Glu Gly Met 
    1775                 1780                 1785             


Lys Glu  Asp Val Val His Met  Lys Gly Pro Val Glu  Ile Ile Lys 
    1790                 1795                 1800             


Asp Asp  Leu Gln Gln Gln Leu  Pro Gln Tyr Met Ile  Pro Asn Lys 
    1805                 1810                 1815             


Val Leu  Val Phe Asp Lys Leu  Pro Leu Thr Ala Asn  Gly Lys Val 
    1820                 1825                 1830             


Asp Tyr  Gln Ser Leu Ser Glu  Ser Lys Ala Val Glu  Asn Val Ser 
    1835                 1840                 1845             


Thr Gln  Arg Leu Leu Val Pro  Leu His Thr Asp Thr  Glu Ile Arg 
    1850                 1855                 1860             


Leu Gly  Lys Ile Trp Met Glu  Val Leu Lys Trp Asp  Ser Val Ser 
    1865                 1870                 1875             


Ala Leu  Asp Asp Phe Phe Glu  Ser Gly Gly Asn Ser  Leu Met Ala 
    1880                 1885                 1890             


Val Ala  Met Val Asn Lys Ile  Asn Ala Ala Phe Asn  Ile Arg Phe 
    1895                 1900                 1905             


Pro Leu  Gln Ile Leu Phe Gln  Ser Pro Asn Ile Ala  Glu Leu Ala 
    1910                 1915                 1920             


Lys Trp  Ile Glu Gln Thr Asp  Ser Lys Thr Ile Ser  Arg Leu Ile 
    1925                 1930                 1935             


Leu Leu  Asn Gln Ala Ser Lys  Asp Pro Ile Tyr Cys  Trp Pro Gly 
    1940                 1945                 1950             


Leu Gly  Gly Tyr Pro Met Ser  Leu Arg Leu Leu Ala  Asn Lys Val 
    1955                 1960                 1965             


Val Pro  Asp Arg Ala Phe Tyr  Gly Ile Gln Ala Tyr  Gly Ile Asn 
    1970                 1975                 1980             


Glu Ser  Glu Ile Pro Phe Ser  Ser Ile Gln Arg Met  Ala Glu Glu 
    1985                 1990                 1995             


Asp Ile  Lys Glu Ile Lys Lys  Ile Gln Pro Glu Gly  Pro Tyr Ile 
    2000                 2005                 2010             


Leu Trp  Gly Tyr Ser Phe Gly  Ala Arg Val Ala Phe  Glu Val Ala 
    2015                 2020                 2025             


Tyr Gln  Leu Glu Gln Ala Gly  Glu Glu Val Asn Ala  Leu Asn Leu 
    2030                 2035                 2040             


Leu Ala  Pro Gly Ser Pro His  Leu Asp Met Lys Gln  Ala Glu Tyr 
    2045                 2050                 2055             


Met Asp  Lys Gly Ala Glu Phe  Thr Asn Pro Ala Phe  Val Lys Ile 
    2060                 2065                 2070             


Leu Phe  Ser Val Phe Ser Arg  Ser Ile Asn Ser Pro  Met Val Lys 
    2075                 2080                 2085             


Thr Cys  Leu Glu Gln Val Asn  Ser Glu Thr Thr Phe  Ile Asn Phe 
    2090                 2095                 2100             


Ile Cys  Ser Arg Phe Lys Asn  Leu Glu Pro Ser Leu  Val Lys Arg 
    2105                 2110                 2115             


Ile Val  Arg Ile Val Thr Leu  Thr Tyr Asp Phe Lys  Tyr Ser Ile 
    2120                 2125                 2130             


Asp Glu  Leu Tyr His Arg His  Leu Lys Ala Pro Ile  Thr Ile Phe 
    2135                 2140                 2145             


Lys Ala  Asn Arg Asp Asn Asp  Ser Phe Ile Glu Glu  Ser Asp Val 
    2150                 2155                 2160             


Ile Ser  Ser Met Ser Pro Lys  Ile Ile Glu Leu Ile  Ser Asp His 
    2165                 2170                 2175             


Tyr Gln  Leu Leu Glu Ser Glu  Gly Val Ala Glu Ile  Glu Lys Ile 
    2180                 2185                 2190             


Ile 
    


<210>  31
<211>  4744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Indigoidine-tagged Tripeptide consisting 
       of Phenylalanine, Ornithine and Leucine

<400>  31

Met Leu Ala Asn Gln Ala Asn Leu Ile Asp Asn Lys Arg Glu Leu Glu 
1               5                   10                  15      


Gln His Ala Leu Val Pro Tyr Ala Gln Gly Lys Ser Ile His Gln Leu 
            20                  25                  30          


Phe Glu Glu Gln Ala Glu Ala Phe Pro Asp Arg Val Ala Ile Val Phe 
        35                  40                  45              


Glu Asn Arg Arg Leu Ser Tyr Gln Glu Leu Asn Arg Lys Ala Asn Gln 
    50                  55                  60                  


Leu Ala Arg Ala Leu Leu Glu Lys Gly Val Gln Thr Asp Ser Ile Val 
65                  70                  75                  80  


Gly Val Met Met Glu Lys Ser Ile Glu Asn Val Ile Ala Ile Leu Ala 
                85                  90                  95      


Val Leu Lys Ala Gly Gly Ala Tyr Val Pro Ile Asp Ile Glu Tyr Pro 
            100                 105                 110         


Arg Asp Arg Ile Gln Tyr Ile Leu Gln Asp Ser Gln Thr Lys Ile Val 
        115                 120                 125             


Leu Thr Gln Lys Ser Val Ser Gln Leu Val His Asp Val Gly Tyr Ser 
    130                 135                 140                 


Gly Glu Val Val Val Leu Asp Glu Glu Gln Leu Asp Ala Arg Glu Thr 
145                 150                 155                 160 


Ala Asn Leu His Gln Pro Ser Lys Pro Thr Asp Leu Ala Tyr Val Ile 
                165                 170                 175     


Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Thr Met Leu Glu His 
            180                 185                 190         


Lys Gly Ile Ala Asn Leu Gln Ser Phe Phe Gln Asn Ser Phe Gly Val 
        195                 200                 205             


Thr Glu Gln Asp Arg Ile Gly Leu Phe Ala Ser Met Ser Phe Asp Ala 
    210                 215                 220                 


Ser Val Trp Glu Met Phe Met Ala Leu Leu Ser Gly Ala Ser Leu Tyr 
225                 230                 235                 240 


Ile Leu Ser Lys Gln Thr Ile His Asp Phe Ala Ala Phe Glu His Tyr 
                245                 250                 255     


Leu Ser Glu Asn Glu Leu Thr Ile Ile Thr Leu Pro Pro Thr Tyr Leu 
            260                 265                 270         


Thr His Leu Thr Pro Glu Arg Ile Thr Ser Leu Arg Ile Met Ile Thr 
        275                 280                 285             


Ala Gly Ser Ala Ser Ser Ala Pro Leu Val Asn Lys Trp Lys Asp Lys 
    290                 295                 300                 


Leu Arg Tyr Ile Asn Ala Tyr Gly Pro Thr Glu Thr Ser Ile Cys Ala 
305                 310                 315                 320 


Thr Ile Trp Glu Ala Pro Ser Asn Gln Leu Ser Val Gln Ser Val Pro 
                325                 330                 335     


Ile Gly Lys Pro Ile Gln Asn Thr His Ile Tyr Ile Val Asn Glu Asp 
            340                 345                 350         


Leu Gln Leu Leu Pro Thr Gly Ser Glu Gly Glu Leu Cys Ile Gly Gly 
        355                 360                 365             


Val Gly Leu Ala Arg Gly Tyr Trp Asn Arg Pro Asp Leu Thr Ala Glu 
    370                 375                 380                 


Lys Phe Val Asp Asn Pro Phe Val Pro Gly Glu Lys Met Tyr Arg Thr 
385                 390                 395                 400 


Gly Asp Leu Ala Lys Trp Leu Thr Asp Gly Thr Ile Glu Phe Leu Gly 
                405                 410                 415     


Arg Ile Asp His Gln Val Lys Ile Arg Gly His Arg Ile Glu Leu Gly 
            420                 425                 430         


Glu Ile Glu Ser Val Leu Leu Ala His Glu His Ile Thr Glu Ala Val 
        435                 440                 445             


Val Ile Ala Arg Glu Asp Gln His Ala Gly Gln Tyr Leu Cys Ala Tyr 
    450                 455                 460                 


Tyr Ile Ser Gln Gln Glu Ala Thr Pro Ala Gln Leu Arg Asp Tyr Ala 
465                 470                 475                 480 


Ala Gln Lys Leu Pro Ala Tyr Met Leu Pro Ser Tyr Phe Val Lys Leu 
                485                 490                 495     


Asp Lys Met Pro Leu Thr Pro Asn Asp Lys Ile Asp Arg Lys Ala Leu 
            500                 505                 510         


Pro Glu Pro Asp Leu Thr Ala Asn Gln Ser Gln Ala Ala Tyr His Pro 
        515                 520                 525             


Pro Arg Thr Glu Thr Glu Ser Ile Leu Val Ser Ile Trp Gln Asn Val 
    530                 535                 540                 


Leu Gly Ile Glu Lys Ile Gly Ile Arg Asp Asn Phe Tyr Ser Leu Gly 
545                 550                 555                 560 


Gly Asp Ser Ile Gln Ala Ile Gln Val Val Ala Arg Leu His Ser Tyr 
                565                 570                 575     


Gln Leu Lys Leu Glu Thr Lys Asp Leu Leu Asn Tyr Pro Thr Ile Glu 
            580                 585                 590         


Gln Val Ala Leu Phe Val Lys Ser Thr Thr Arg Lys Ser Asp Gln Gly 
        595                 600                 605             


Ile Ile Ala Gly Asn Val Pro Leu Thr Pro Ile Gln Lys Trp Phe Phe 
    610                 615                 620                 


Gly Lys Asn Phe Thr Asn Thr Gly His Trp Asn Gln Ser Ser Val Leu 
625                 630                 635                 640 


Tyr Arg Pro Glu Gly Phe Asp Pro Lys Val Ile Gln Ser Val Met Asp 
                645                 650                 655     


Lys Ile Ile Glu His His Asp Ala Leu Arg Met Val Tyr Gln His Glu 
            660                 665                 670         


Asn Gly Asn Val Val Gln His Asn Arg Gly Leu Gly Gly Gln Leu Tyr 
        675                 680                 685             


Asp Phe Phe Ser Tyr Asn Leu Thr Ala Gln Pro Asp Val Gln Gln Ala 
    690                 695                 700                 


Ile Glu Ala Glu Thr Gln Arg Leu His Ser Ser Met Asn Leu Gln Glu 
705                 710                 715                 720 


Gly Pro Leu Val Lys Val Ala Leu Phe Gln Thr Leu His Gly Asp His 
                725                 730                 735     


Leu Phe Leu Ala Ile His His Leu Val Val Asp Gly Ile Ser Trp Arg 
            740                 745                 750         


Ile Leu Phe Glu Asp Leu Ala Thr Gly Tyr Ala Gln Ala Leu Ala Gly 
        755                 760                 765             


Gln Ala Ile Ser Leu Pro Glu Lys Thr Asp Ser Phe Gln Ser Trp Ser 
    770                 775                 780                 


Gln Trp Leu Gln Glu Tyr Ala Asn Glu Ala Asp Leu Leu Ser Glu Ile 
785                 790                 795                 800 


Pro Tyr Trp Glu Ser Leu Glu Ser Gln Ala Lys Asn Val Ser Leu Pro 
                805                 810                 815     


Lys Asp Tyr Glu Val Thr Asp Cys Lys Gln Lys Ser Val Arg Asn Met 
            820                 825                 830         


Arg Ile Arg Leu His Pro Glu Glu Thr Glu Gln Leu Leu Lys His Ala 
        835                 840                 845             


Asn Gln Ala Tyr Gln Thr Glu Ile Asn Asp Leu Leu Leu Ala Ala Leu 
    850                 855                 860                 


Gly Leu Ala Phe Ala Glu Trp Ser Lys Leu Ala Gln Ile Val Ile His 
865                 870                 875                 880 


Leu Glu Gly His Gly Arg Glu Asp Ile Ile Glu Gln Ala Asn Val Ala 
                885                 890                 895     


Arg Thr Val Gly Trp Phe Thr Ser Gln Tyr Pro Val Leu Leu Asp Leu 
            900                 905                 910         


Lys Gln Thr Ala Pro Leu Ser Asp Tyr Ile Lys Leu Thr Lys Glu Asn 
        915                 920                 925             


Met Arg Lys Ile Pro Arg Lys Gly Ile Gly Tyr Asp Ile Leu Lys His 
    930                 935                 940                 


Val Thr Leu Pro Glu Asn Arg Gly Ser Leu Ser Phe Arg Val Gln Pro 
945                 950                 955                 960 


Glu Val Thr Phe Asn Tyr Leu Gly Gln Phe Asp Ala Asp Met Arg Thr 
                965                 970                 975     


Glu Leu Phe Thr Arg Ser Pro Tyr Ser Gly Gly Asn Thr Leu Gly Ala 
            980                 985                 990         


Asp Gly Lys Asn Asn Leu Ser Pro  Glu Ser Glu Val Tyr  Thr Ala Leu 
        995                 1000                 1005             


Asn Ile  Thr Gly Leu Ile Glu  Gly Gly Glu Leu Val  Leu Thr Phe 
    1010                 1015                 1020             


Ser Tyr  Ser Ser Glu Gln Tyr  Arg Glu Glu Ser Ile  Gln Gln Leu 
    1025                 1030                 1035             


Ser Gln  Ser Tyr Gln Lys His  Leu Leu Ala Ile Ile  Ala His Cys 
    1040                 1045                 1050             


Thr Glu  Lys Lys Glu Val Glu  Arg Thr Ala His Ile  Ala Glu Ser 
    1055                 1060                 1065             


Ala Phe  Glu Gln Phe Glu Thr  Ile Gln Pro Val Glu  Pro Ala Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Val Ser Phe Ala  Gln Lys Arg Met Tyr  Ile Leu His 
    1085                 1090                 1095             


Gln Phe  Glu Gly Ser Gly Ile  Ser Tyr Asn Val Pro  Ser Val Leu 
    1100                 1105                 1110             


Val Leu  Glu Gly Lys Leu Asp  Tyr Asp Arg Phe Ala  Ala Ala Ile 
    1115                 1120                 1125             


Gln Ser  Leu Val Lys Arg His  Glu Ser Leu Arg Thr  Ser Phe His 
    1130                 1135                 1140             


Ser Val  Asn Gly Glu Pro Leu  Gln Arg Val His Pro  Asp Val Glu 
    1145                 1150                 1155             


Leu Pro  Val Arg Leu Leu Glu  Ala Thr Glu Asp Gln  Ser Glu Ser 
    1160                 1165                 1170             


Leu Ile  Gln Glu Leu Ile Gln  Pro Phe Asp Leu Glu  Ile Ala Pro 
    1175                 1180                 1185             


Leu Phe  Arg Val Asn Leu Ile  Lys Leu Gly Ala Glu  Arg His Leu 
    1190                 1195                 1200             


Phe Phe  Met Asp Met His His  Ile Ile Ser Asp Gly  Val Ser Leu 
    1205                 1210                 1215             


Ala Val  Ile Val Glu Glu Ile  Ala Ser Leu Tyr Ala  Gly Lys Gln 
    1220                 1225                 1230             


Leu Ser  Asp Leu Arg Ile Gln  Tyr Lys Asp Phe Ala  Val Trp Gln 
    1235                 1240                 1245             


Thr Lys  Leu Ala Gln Ser Asp  Arg Phe Gln Lys Gln  Glu Asp Phe 
    1250                 1255                 1260             


Trp Thr  Arg Thr Phe Ala Gly  Glu Ile Pro Leu Leu  Asn Leu Pro 
    1265                 1270                 1275             


His Asp  Tyr Pro Arg Pro Ser  Val Gln Ser Phe Asp  Gly Asp Thr 
    1280                 1285                 1290             


Val Ala  Leu Gly Thr Gly His  His Leu Leu Glu Gln  Leu Arg Lys 
    1295                 1300                 1305             


Leu Ala  Ala Glu Thr Gly Thr  Thr Leu Phe Met Val  Leu Leu Ala 
    1310                 1315                 1320             


Ala Tyr  His Val Leu Leu Ser  Lys Tyr Ala Gly Gln  Glu Glu Ile 
    1325                 1330                 1335             


Val Val  Gly Thr Pro Ile Ala  Gly Arg Ser His Ala  Asp Val Glu 
    1340                 1345                 1350             


Arg Ile  Val Gly Met Phe Val  Asn Thr Leu Ala Leu  Lys Asn Thr 
    1355                 1360                 1365             


Ala Ala  Gly Ser Leu Ser Phe  Arg Ala Phe Leu Glu  Asp Val Lys 
    1370                 1375                 1380             


Gln Asn  Ala Leu His Ala Phe  Glu His Gln Asp Tyr  Pro Phe Glu 
    1385                 1390                 1395             


His Leu  Val Glu Lys Leu Gln  Val Arg Arg Asp Leu  Ser Arg Asn 
    1400                 1405                 1410             


Pro Leu  Phe Asp Thr Met Phe  Ser Leu Gly Leu Ala  Glu Ser Ala 
    1415                 1420                 1425             


Glu Gly  Glu Val Ala Asp Leu  Lys Val Ser Pro Tyr  Pro Val Asn 
    1430                 1435                 1440             


Gly His  Ile Ala Lys Phe Asp  Leu Ser Leu Asp Ala  Met Glu Lys 
    1445                 1450                 1455             


Gln Asp  Gly Leu Leu Val Gln  Phe Ser Tyr Cys Thr  Lys Leu Phe 
    1460                 1465                 1470             


Ala Lys  Glu Thr Val Asp Arg  Leu Ala Ala His Tyr  Val Gln Leu 
    1475                 1480                 1485             


Leu Gln  Thr Ile Thr Ala Asp  Pro Asp Ile Glu Leu  Ala Arg Ile 
    1490                 1495                 1500             


Ser Val  Leu Ser Lys Ala Glu  Thr Glu His Met Leu  His Ser Phe 
    1505                 1510                 1515             


Leu Ala  Thr Lys Thr Ala Tyr  Pro Thr Asp Lys Thr  Phe Gln Lys 
    1520                 1525                 1530             


Leu Phe  Glu Glu Gln Val Glu  Lys Thr Pro Asn Glu  Ile Ala Val 
    1535                 1540                 1545             


Leu Phe  Gly Asn Glu Gln Leu  Thr Tyr Gln Glu Leu  Asn Ala Lys 
    1550                 1555                 1560             


Ala Asn  Gln Leu Ala Arg Val  Leu Arg Arg Lys Gly  Val Lys Pro 
    1565                 1570                 1575             


Glu Ser  Thr Val Gly Ile Leu  Val Asp Arg Ser Leu  Tyr Met Val 
    1580                 1585                 1590             


Ile Gly  Met Leu Ala Val Leu  Lys Ala Gly Gly Thr  Phe Val Pro 
    1595                 1600                 1605             


Ile Asp  Pro Asp Tyr Pro Leu  Glu Arg Gln Ala Phe  Met Leu Glu 
    1610                 1615                 1620             


Asp Ser  Glu Ala Lys Leu Leu  Leu Thr Leu Gln Lys  Met Asn Ser 
    1625                 1630                 1635             


Gln Val  Ala Phe Pro Tyr Glu  Thr Phe Tyr Leu Asp  Thr Glu Thr 
    1640                 1645                 1650             


Val Asp  Gln Glu Glu Thr Gly  Asn Leu Glu His Val  Ala Gln Pro 
    1655                 1660                 1665             


Glu Asn  Val Ala Tyr Ile Ile  Tyr Thr Ser Gly Thr  Thr Gly Lys 
    1670                 1675                 1680             


Pro Lys  Gly Val Val Ile Glu  His Arg Ser Tyr Ala  Asn Val Ala 
    1685                 1690                 1695             


Phe Ala  Trp Lys Asp Glu Tyr  His Leu Asp Ser Phe  Pro Val Arg 
    1700                 1705                 1710             


Leu Leu  Gln Met Ala Ser Phe  Ala Phe Asp Val Ser  Thr Gly Asp 
    1715                 1720                 1725             


Phe Ala  Arg Ala Leu Leu Thr  Gly Gly Gln Leu Val  Ile Cys Pro 
    1730                 1735                 1740             


Asn Gly  Val Lys Met Asp Pro  Ala Ser Leu Tyr Glu  Thr Ile Arg 
    1745                 1750                 1755             


Arg His  Glu Ile Thr Ile Phe  Glu Ala Thr Pro Ala  Leu Ile Met 
    1760                 1765                 1770             


Pro Leu  Met His Tyr Val Tyr  Glu Asn Glu Leu Asp  Met Ser Gln 
    1775                 1780                 1785             


Met Lys  Leu Leu Ile Leu Gly  Ala Asp Ser Cys Pro  Ala Glu Asp 
    1790                 1795                 1800             


Phe Lys  Thr Leu Leu Ala Arg  Phe Gly Gln Lys Met  Arg Ile Ile 
    1805                 1810                 1815             


Asn Ser  Tyr Gly Val Thr Glu  Ala Cys Ile Asp Thr  Ser Tyr Tyr 
    1820                 1825                 1830             


Glu Glu  Thr Asp Val Thr Ala  Ile Arg Ser Gly Thr  Val Pro Ile 
    1835                 1840                 1845             


Gly Lys  Pro Leu Pro Asn Met  Thr Met Tyr Val Val  Asp Ala His 
    1850                 1855                 1860             


Leu Asn  Leu Gln Pro Val Gly  Val Val Gly Glu Leu  Cys Ile Gly 
    1865                 1870                 1875             


Gly Ala  Gly Val Ala Arg Gly  Tyr Leu Asn Arg Pro  Glu Leu Thr 
    1880                 1885                 1890             


Glu Glu  Lys Phe Val Pro Asn  Pro Phe Ala Pro Gly  Glu Arg Leu 
    1895                 1900                 1905             


Tyr Arg  Thr Gly Asp Leu Ala  Lys Trp Arg Ala Asp  Gly Asn Val 
    1910                 1915                 1920             


Glu Phe  Leu Gly Arg Asn Asp  His Gln Val Lys Ile  Arg Gly Val 
    1925                 1930                 1935             


Arg Ile  Glu Leu Gly Glu Ile  Glu Thr Gln Leu Arg  Lys Leu Asp 
    1940                 1945                 1950             


Gly Ile  Thr Glu Ala Val Val  Val Ala Arg Glu Asp  Arg Gly Gln 
    1955                 1960                 1965             


Glu Lys  Glu Leu Cys Ala Tyr  Val Val Ala Asp His  Lys Leu Asp 
    1970                 1975                 1980             


Thr Ala  Glu Leu Arg Ala Asn  Leu Leu Lys Glu Leu  Pro Gln Ala 
    1985                 1990                 1995             


Met Ile  Pro Ala Tyr Phe Val  Thr Leu Asp Ala Leu  Pro Leu Thr 
    2000                 2005                 2010             


Ala Asn  Gly Lys Val Asp Arg  Arg Ser Leu Pro Ala  Pro Asp Val 
    2015                 2020                 2025             


Thr Met  Leu Arg Thr Thr Glu  Tyr Val Ala Pro Arg  Ser Val Trp 
    2030                 2035                 2040             


Glu Ala  Arg Leu Ala Gln Val  Trp Glu Gln Val Leu  Asn Val Pro 
    2045                 2050                 2055             


Gln Val  Gly Ala Leu Asp Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    2060                 2065                 2070             


Leu Arg  Ala Met Arg Val Leu  Ser Ser Met His Asn  Glu Tyr Gln 
    2075                 2080                 2085             


Val Asp  Ile Pro Leu Arg Ile  Leu Phe Glu Lys Pro  Thr Ile Gln 
    2090                 2095                 2100             


Glu Leu  Ala Ala Phe Ile Glu  Glu Thr Ala Lys Gly  Asn Val Phe 
    2105                 2110                 2115             


Ser Ile  Glu Pro Val Gln Lys  Gln Ala Tyr Tyr Pro  Val Ser Ser 
    2120                 2125                 2130             


Ala Gln  Lys Arg Met Tyr Ile  Leu Asp Gln Phe Glu  Gly Val Gly 
    2135                 2140                 2145             


Ile Ser  Tyr Asn Met Pro Ser  Thr Met Leu Ile Glu  Gly Lys Leu 
    2150                 2155                 2160             


Glu Arg  Thr Arg Val Glu Ala  Ala Phe Gln Arg Leu  Ile Ala Arg 
    2165                 2170                 2175             


His Glu  Ser Leu Arg Thr Ser  Phe Ala Val Val Asn  Gly Glu Pro 
    2180                 2185                 2190             


Val Gln  Asn Ile His Glu Asp  Val Pro Phe Ala Leu  Ala Tyr Ser 
    2195                 2200                 2205             


Glu Val  Thr Glu Gln Glu Ala  Arg Glu Leu Val Ser  Ser Leu Val 
    2210                 2215                 2220             


Gln Pro  Phe Asp Leu Glu Val  Ala Pro Leu Ile Arg  Val Ser Leu 
    2225                 2230                 2235             


Leu Lys  Ile Gly Glu Asp Arg  Tyr Val Leu Phe Thr  Asp Met His 
    2240                 2245                 2250             


His Ser  Ile Ser Asp Gly Val  Ser Ser Gly Ile Leu  Leu Ala Glu 
    2255                 2260                 2265             


Trp Val  Gln Leu Tyr Gln Gly  Asp Val Leu Pro Glu  Leu Arg Ile 
    2270                 2275                 2280             


Gln Tyr  Lys Asp Phe Ala Val  Trp Gln Gln Glu Phe  Ser Gln Ser 
    2285                 2290                 2295             


Ala Ala  Phe His Lys Gln Glu  Ala Tyr Trp Leu Gln  Thr Phe Ala 
    2300                 2305                 2310             


Asp Asp  Ile Pro Val Leu Asn  Leu Pro Thr Asp Phe  Thr Arg Pro 
    2315                 2320                 2325             


Ser Thr  Gln Ser Phe Ala Gly  Asp Gln Cys Thr Ile  Gly Ala Gly 
    2330                 2335                 2340             


Lys Ala  Leu Thr Glu Gly Leu  His Gln Leu Ala Gln  Ala Thr Gly 
    2345                 2350                 2355             


Thr Thr  Leu Tyr Met Val Leu  Leu Ala Ala Tyr Asn  Val Leu Leu 
    2360                 2365                 2370             


Ala Lys  Tyr Ala Gly Gln Glu  Asp Ile Ile Val Gly  Thr Pro Ile 
    2375                 2380                 2385             


Thr Gly  Arg Ser His Ala Asp  Leu Glu Pro Ile Val  Gly Met Phe 
    2390                 2395                 2400             


Val Asn  Thr Leu Ala Met Arg  Asn Lys Pro Gln Arg  Glu Lys Thr 
    2405                 2410                 2415             


Phe Ser  Glu Phe Leu Gln Glu  Val Lys Gln Asn Ala  Leu Asp Ala 
    2420                 2425                 2430             


Tyr Gly  His Gln Asp Tyr Pro  Phe Glu Glu Leu Val  Glu Lys Leu 
    2435                 2440                 2445             


Ala Ile  Ala Arg Asp Leu Ser  Arg Asn Pro Leu Phe  Asp Thr Val 
    2450                 2455                 2460             


Phe Thr  Phe Gln Asn Ser Thr  Glu Glu Val Met Thr  Leu Pro Glu 
    2465                 2470                 2475             


Cys Thr  Leu Ala Pro Phe Met  Thr Asp Glu Thr Gly  Gln His Ala 
    2480                 2485                 2490             


Lys Phe  Asp Leu Thr Phe Ser  Ala Thr Glu Glu Arg  Glu Glu Met 
    2495                 2500                 2505             


Thr Ile  Gly Val Glu Tyr Ser  Thr Ser Leu Phe Thr  Arg Glu Thr 
    2510                 2515                 2520             


Met Glu  Arg Phe Ser Arg His  Phe Leu Thr Ile Ala  Ala Ser Ile 
    2525                 2530                 2535             


Val Gln  Asn Pro His Ile Arg  Leu Gly Glu Ile Asp  Met Leu Leu 
    2540                 2545                 2550             


Pro Glu  Glu Lys Gln Gln Ile  Leu Ala Gly Phe Asn  Asp Thr Ala 
    2555                 2560                 2565             


Val Ser  Tyr Ala Leu Asp Lys  Thr Leu His Gln Leu  Phe Glu Glu 
    2570                 2575                 2580             


Gln Val  Asp Lys Thr Pro Asp  Gln Ala Ala Leu Leu  Phe Ser Glu 
    2585                 2590                 2595             


Gln Ser  Leu Thr Tyr Ser Glu  Leu Asn Glu Arg Ala  Asn Arg Leu 
    2600                 2605                 2610             


Ala Arg  Val Leu Arg Ala Lys  Gly Val Gly Pro Asp  Arg Leu Val 
    2615                 2620                 2625             


Ala Ile  Met Ala Glu Arg Ser  Pro Glu Met Val Ile  Gly Ile Leu 
    2630                 2635                 2640             


Gly Ile  Leu Lys Ala Gly Gly  Ala Tyr Val Pro Val  Asp Pro Gly 
    2645                 2650                 2655             


Tyr Pro  Gln Glu Arg Ile Gln  Tyr Leu Leu Glu Asp  Ser Asn Ala 
    2660                 2665                 2670             


Ala Leu  Leu Leu Ser Gln Ala  His Leu Leu Pro Leu  Leu Ala Gln 
    2675                 2680                 2685             


Val Ser  Ser Glu Leu Pro Glu  Cys Leu Asp Leu Asn  Ala Glu Leu 
    2690                 2695                 2700             


Asp Ala  Gly Leu Ser Gly Ser  Asn Leu Pro Ala Val  Asn Gln Pro 
    2705                 2710                 2715             


Thr Asp  Leu Ala Tyr Val Ile  Tyr Thr Ser Gly Thr  Thr Gly Lys 
    2720                 2725                 2730             


Pro Lys  Gly Val Met Ile Pro  His Gln Gly Ile Val  Asn Cys Leu 
    2735                 2740                 2745             


Gln Trp  Arg Arg Asp Glu Tyr  Gly Phe Gly Pro Ser  Asp Lys Ala 
    2750                 2755                 2760             


Leu Gln  Val Phe Ser Phe Ala  Phe Asp Gly Phe Val  Ala Ser Leu 
    2765                 2770                 2775             


Phe Ala  Pro Leu Leu Gly Gly  Ala Thr Cys Val Leu  Pro Gln Glu 
    2780                 2785                 2790             


Ala Ala  Ala Lys Asp Pro Val  Ala Leu Lys Lys Leu  Met Ala Ala 
    2795                 2800                 2805             


Thr Glu  Val Thr His Tyr Tyr  Gly Val Pro Ser Leu  Phe Gln Ala 
    2810                 2815                 2820             


Ile Leu  Asp Cys Ser Thr Thr  Thr Asp Phe Asn Gln  Leu Arg Cys 
    2825                 2830                 2835             


Val Thr  Leu Gly Gly Glu Lys  Leu Pro Val Gln Leu  Val Gln Lys 
    2840                 2845                 2850             


Thr Lys  Glu Lys His Pro Ala  Ile Glu Ile Asn Asn  Glu Tyr Gly 
    2855                 2860                 2865             


Pro Thr  Glu Asn Ser Val Val  Thr Thr Ile Ser Arg  Ser Ile Glu 
    2870                 2875                 2880             


Ala Gly  Gln Ala Ile Thr Ile  Gly Arg Pro Leu Ala  Asn Val Gln 
    2885                 2890                 2895             


Val Tyr  Ile Val Asp Glu Gln  His His Leu Gln Pro  Ile Gly Val 
    2900                 2905                 2910             


Val Gly  Glu Leu Cys Ile Gly  Gly Ala Gly Leu Ala  Arg Gly Tyr 
    2915                 2920                 2925             


Leu Asn  Lys Pro Glu Leu Thr  Ala Glu Lys Phe Val  Ala Asn Pro 
    2930                 2935                 2940             


Phe Arg  Pro Gly Glu Arg Met  Tyr Lys Thr Gly Asp  Leu Val Lys 
    2945                 2950                 2955             


Trp Arg  Thr Asp Gly Thr Ile  Glu Tyr Ile Gly Arg  Ala Asp Glu 
    2960                 2965                 2970             


Gln Val  Lys Val Arg Gly Tyr  Arg Ile Glu Ile Gly  Glu Ile Glu 
    2975                 2980                 2985             


Ser Ala  Val Leu Ala Tyr Gln  Gly Ile Asp Gln Ala  Val Val Val 
    2990                 2995                 3000             


Ala Arg  Asp Asp Asp Ala Thr  Ala Gly Ser Tyr Leu  Cys Ala Tyr 
    3005                 3010                 3015             


Phe Val  Ala Ala Thr Ala Val  Ser Val Ser Gly Leu  Arg Ser His 
    3020                 3025                 3030             


Leu Ala  Lys Glu Leu Pro Ala  Tyr Met Ile Pro Ser  Tyr Phe Val 
    3035                 3040                 3045             


Glu Leu  Asp Gln Leu Pro Leu  Ser Ala Asn Gly Lys  Val Asp Arg 
    3050                 3055                 3060             


Lys Ala  Leu Pro Lys Pro Gln  Gln Ser Asp Ala Thr  Thr Arg Glu 
    3065                 3070                 3075             


Tyr Val  Ala Pro Arg Asn Ala  Thr Glu Gln Gln Leu  Ala Ala Ile 
    3080                 3085                 3090             


Trp Gln  Glu Val Leu Gly Val  Glu Pro Ile Gly Ile  Thr Asp Gln 
    3095                 3100                 3105             


Phe Phe  Glu Leu Gly Gly His  Ser Leu Lys Ala Thr  Leu Leu Ile 
    3110                 3115                 3120             


Ala Lys  Val Tyr Glu Tyr Met  Gln Ile Glu Leu Pro  Leu Asn Leu 
    3125                 3130                 3135             


Ile Phe  Gln Tyr Pro Thr Ile  Glu Lys Val Ala Asp  Phe Ile Thr 
    3140                 3145                 3150             


Ser Glu  Lys Thr Glu Tyr Thr  Ala Ile Gln Pro Val  Ala Ala Gln 
    3155                 3160                 3165             


Glu Phe  Tyr Pro Val Ser Ser  Ala Gln Lys Arg Met  Tyr Ile Leu 
    3170                 3175                 3180             


Gln Gln  Phe Glu Gly Asn Gly  Ile Ser Tyr Asn Ile  Ser Gly Ala 
    3185                 3190                 3195             


Ile Leu  Leu Glu Gly Lys Leu  Asp Tyr Ala Arg Phe  Ala Ser Ala 
    3200                 3205                 3210             


Val Gln  Gln Leu Ala Glu Arg  His Glu Ala Leu Arg  Thr Ser Phe 
    3215                 3220                 3225             


His Arg  Ile Asp Gly Glu Pro  Val Gln Lys Val His  Glu Glu Val 
    3230                 3235                 3240             


Glu Val  Pro Leu Phe Met Leu  Glu Ala Pro Glu Asp  Gln Ala Glu 
    3245                 3250                 3255             


Lys Ile  Met Arg Glu Phe Val  Arg Pro Phe Asp Leu  Gly Val Ala 
    3260                 3265                 3270             


Pro Leu  Met Arg Thr Gly Leu  Leu Lys Leu Gly Lys  Asp Arg His 
    3275                 3280                 3285             


Leu Phe  Leu Leu Asp Met His  His Ile Ile Ser Asp  Gly Val Ser 
    3290                 3295                 3300             


Ser Gln  Ile Leu Leu Arg Glu  Phe Ala Glu Leu Tyr  Gln Gly Ala 
    3305                 3310                 3315             


Asp Leu  Gln Pro Leu Ser Leu  Gln Tyr Lys Asp Phe  Ala Ala Trp 
    3320                 3325                 3330             


Gln Asn  Glu Leu Phe Gln Thr  Glu Ala Tyr Lys Lys  Gln Glu Gln 
    3335                 3340                 3345             


His Trp  Leu Asn Thr Phe Ala  Asp Glu Ile Pro Leu  Leu Asn Leu 
    3350                 3355                 3360             


Pro Thr  Asp Tyr Pro Arg Pro  Ser Val Gln Ser Phe  Ala Gly Asp 
    3365                 3370                 3375             


Leu Val  Leu Phe Ala Ala Gly  Lys Glu Leu Leu Glu  Arg Leu Gln 
    3380                 3385                 3390             


Gln Val  Ala Ser Glu Thr Gly  Thr Thr Leu Tyr Met  Ile Leu Leu 
    3395                 3400                 3405             


Ala Ala  Tyr Asn Val Leu Leu  Ser Lys Tyr Thr Gly  Gln Glu Asp 
    3410                 3415                 3420             


Ile Ile  Val Gly Thr Pro Val  Ala Gly Arg Ser His  Ala Asp Val 
    3425                 3430                 3435             


Glu Asn  Ile Met Gly Ile Phe  Val Asn Thr Leu Ala  Leu Arg Asn 
    3440                 3445                 3450             


Gln Pro  Ala Ser Ser Lys Thr  Met Leu Glu Asn Asn  Ile Thr Gln 
    3455                 3460                 3465             


Cys Asp  Ser Ile Asn Asp Val  Tyr Leu Lys Glu Glu  Ala Ile Thr 
    3470                 3475                 3480             


Leu Met  Asp Met Leu Glu Ser  Gln Leu Lys His Gln  Ala Asp Gly 
    3485                 3490                 3495             


Tyr Val  Val Ile Asp Gln Glu  Glu Ser Leu Ser Tyr  Ala Asp Phe 
    3500                 3505                 3510             


Tyr Leu  Arg Val Lys Glu Ile  Gly Tyr Cys Leu Ser  Glu Ile Ser 
    3515                 3520                 3525             


Ser Lys  Asn Ser Val Gly Ile  Gly Leu Phe Cys Asp  Pro Ser Ile 
    3530                 3535                 3540             


Asp Leu  Ile Cys Gly Ala Trp  Gly Ile Leu Ser Ala  Asp Lys Ala 
    3545                 3550                 3555             


Tyr Leu  Pro Leu Ser Pro Asp  Tyr Pro Thr Glu Arg  Leu Lys Tyr 
    3560                 3565                 3570             


Met Ile  Glu Asp Ser Gly Ile  Asp Val Ile Phe Thr  Gln Ser His 
    3575                 3580                 3585             


Leu Lys  Ala Gln Leu Gln Asp  Ile Ala Pro Lys Ser  Val Leu Ile 
    3590                 3595                 3600             


Met Thr  Pro Glu Asp Val Ala  Leu Thr Ile Lys Thr  Arg Thr Ile 
    3605                 3610                 3615             


Glu Asp  Ile Leu Gly Thr Val  Gln Val Pro Lys Pro  Thr Ser Leu 
    3620                 3625                 3630             


Ala Tyr  Ile Ile Tyr Thr Ser  Gly Ser Thr Gly Lys  Pro Lys Gly 
    3635                 3640                 3645             


Val Met  Ile Glu His His Ser  Ile Val Asn Gln Met  Arg Phe Leu 
    3650                 3655                 3660             


Ala Lys  Ala Phe Lys Leu Gly  Cys His Ser Arg Ile  Leu Gln Lys 
    3665                 3670                 3675             


Thr Pro  Met Ser Phe Asp Ala  Ala Gln Trp Glu Ile  Leu Ala Pro 
    3680                 3685                 3690             


Ala Ile  Gly Gly Gln Val Ile  Met Gly Pro Leu Gly  Cys Tyr Arg 
    3695                 3700                 3705             


Asp Pro  Asp Ala Ile Ile Lys  Thr Ile Leu Gln His  Gln Val Thr 
    3710                 3715                 3720             


Thr Leu  Gln Cys Val Pro Thr  Leu Leu Gln Ala Leu  Leu Asp Asn 
    3725                 3730                 3735             


Pro Asn  Phe Leu Asp Cys Leu  Ser Leu Thr Gln Val  Phe Ser Gly 
    3740                 3745                 3750             


Gly Glu  Ala Leu Thr Thr Lys  Leu Ala Thr Gln Phe  Leu Asn Ser 
    3755                 3760                 3765             


Phe Thr  His Cys Glu Leu Ile  Asn Leu Tyr Gly Pro  Thr Glu Cys 
    3770                 3775                 3780             


Thr Ile  Asn Ser Ser Phe Phe  Arg Val Thr Asn Glu  Thr Leu Pro 
    3785                 3790                 3795             


Asn Tyr  Gln Thr Ser Ile Ser  Ile Gly Ala Pro Val  Asp Asn Thr 
    3800                 3805                 3810             


Glu Tyr  Tyr Val Leu Asp Asp  Asp Arg Leu Pro Val  Ala Val Gly 
    3815                 3820                 3825             


Glu Ile  Gly Glu Leu Tyr Ile  Ser Gly Ala Gln Leu  Ala Arg Gly 
    3830                 3835                 3840             


Tyr Leu  His Lys Pro Glu Met  Thr Lys Asp Lys Phe  Ile Cys Asn 
    3845                 3850                 3855             


His Leu  Val Ser Gly Thr Gln  His Gln Trp Leu Tyr  Arg Thr Gly 
    3860                 3865                 3870             


Asp Leu  Val Thr Arg Gly Ala  Asp Gly Asn Thr Tyr  Phe Val Gly 
    3875                 3880                 3885             


Arg Val  Asp Ser Gln Val Lys  Leu Arg Gly Tyr Arg  Ile Glu Leu 
    3890                 3895                 3900             


Asp Glu  Ile Arg His Ala Ile  Glu Glu His Ser Trp  Ile Lys Thr 
    3905                 3910                 3915             


Ala Ala  Met Leu Ile Lys Lys  Asp Ala Arg Thr Gly  Phe Gln Asn 
    3920                 3925                 3930             


Leu Ile  Ala Cys Val Glu Leu  Asp Glu Lys Glu Ala  Ala Leu Met 
    3935                 3940                 3945             


Asp Gln  Gly Asn Ser Ser Ser  His His Lys Ser Lys  Ala Asp Lys 
    3950                 3955                 3960             


Leu Gln  Val Lys Ala Gln Leu  Ser Asn Ser Gly Cys  Arg Ser Glu 
    3965                 3970                 3975             


Glu Leu  Cys Glu Asn Arg Pro  Thr Phe Leu Leu Pro  Tyr Gln Glu 
    3980                 3985                 3990             


Gly Glu  Ile Lys Gln Arg Glu  Tyr Ala Phe Gly Arg  Lys Thr Tyr 
    3995                 4000                 4005             


Arg Tyr  Phe Glu Gly Thr Glu  Ile Thr Val Glu Lys  Leu Lys Lys 
    4010                 4015                 4020             


Leu Leu  Thr Ala Thr Gln Ser  Asn Glu Ile Ser Ser  Leu Pro Leu 
    4025                 4030                 4035             


Ser His  Leu Thr Leu Asn Asp  Phe Gly Tyr Ala Leu  Arg Tyr Phe 
    4040                 4045                 4050             


Gly Gln  Phe Thr Ser His Gln  Arg Leu Leu Pro Lys  Tyr Ala Tyr 
    4055                 4060                 4065             


Ala Ser  Pro Gly Ala Leu Tyr  Ala Thr Gln Met Tyr  Phe Glu Leu 
    4070                 4075                 4080             


His Asn  Val Leu Gly Leu Asp  Ala Gly Ile Tyr Tyr  Tyr His Pro 
    4085                 4090                 4095             


Val Thr  His Lys Leu Ile Lys  Ile Ser Thr Leu Ser  Arg Arg Gln 
    4100                 4105                 4110             


Met Pro  Thr Ile Lys Val His  Phe Ile Gly Lys His  Glu Ala Ile 
    4115                 4120                 4125             


Glu Pro  Val Tyr Lys Asn Asn  Ile Gln Glu Val Leu  Glu Met Glu 
    4130                 4135                 4140             


Ala Gly  His Met Met Gly Leu  Phe Asp Asp Val Leu  Pro Glu Ile 
    4145                 4150                 4155             


Gly Leu  Ser Ile Gly Lys Ser  Glu Tyr Gln Asp Glu  Cys Pro Asp 
    4160                 4165                 4170             


Trp Tyr  Asp Gly Asp Ile Gln  Asp Tyr Tyr Leu Gly  Ala Phe Glu 
    4175                 4180                 4185             


Ile Cys  Ser Tyr Glu His Gly  Leu Pro Pro Phe Glu  Thr Asp Ile 
    4190                 4195                 4200             


Tyr Leu  Gln Thr His Ala His  Lys Ile Pro Glu Met  Pro Cys Gly 
    4205                 4210                 4215             


Leu Tyr  His Phe Ser Asn Gly  Glu Phe Val Arg Ile  Ser Asp Asp 
    4220                 4225                 4230             


Ile Val  Arg Lys Lys Asp Val  Ile Ala Ile Asn Gln  Gln Val Tyr 
    4235                 4240                 4245             


Asp Arg  Ser Ser Phe Gly Val  Ser Ile Ile Pro Arg  Cys Val Pro 
    4250                 4255                 4260             


Glu Trp  His Tyr Tyr Ile Thr  Leu Gly Arg Arg Leu  His Ala Leu 
    4265                 4270                 4275             


Gln Ser  Asn Pro Leu Tyr Ile  Gly Leu Met Ser Ser  Gly Tyr Ser 
    4280                 4285                 4290             


Ser Lys  Ser Asn Asn Asp Leu  Pro Ser Ala Lys Arg  Met Arg Ser 
    4295                 4300                 4305             


Ile Leu  Asn Ala Leu Asp Arg  Pro Met Ala Ala Phe  Tyr Phe Cys 
    4310                 4315                 4320             


Ile Gly  Gly Gly Ile Ser Gln  Ala Gln Tyr Met Cys  Glu Gly Met 
    4325                 4330                 4335             


Lys Glu  Asp Val Val His Met  Lys Gly Pro Val Glu  Ile Ile Lys 
    4340                 4345                 4350             


Asp Asp  Leu Gln Gln Gln Leu  Pro Gln Tyr Met Ile  Pro Asn Lys 
    4355                 4360                 4365             


Val Leu  Val Phe Asp Lys Leu  Pro Leu Thr Ala Asn  Gly Lys Val 
    4370                 4375                 4380             


Asp Tyr  Gln Ser Leu Ser Glu  Ser Lys Ala Val Glu  Asn Val Ser 
    4385                 4390                 4395             


Thr Gln  Arg Leu Leu Val Pro  Leu His Thr Asp Thr  Glu Ile Arg 
    4400                 4405                 4410             


Leu Gly  Lys Ile Trp Met Glu  Val Leu Lys Trp Asp  Ser Val Ser 
    4415                 4420                 4425             


Ala Leu  Asp Asp Phe Phe Glu  Ser Gly Gly Asn Ser  Leu Met Ala 
    4430                 4435                 4440             


Val Ala  Met Val Asn Lys Ile  Asn Ala Ala Phe Asn  Ile Arg Phe 
    4445                 4450                 4455             


Pro Leu  Gln Ile Leu Phe Gln  Ser Pro Asn Ile Ala  Glu Leu Ala 
    4460                 4465                 4470             


Lys Trp  Ile Glu Gln Thr Asp  Ser Lys Thr Ile Ser  Arg Leu Ile 
    4475                 4480                 4485             


Leu Leu  Asn Gln Ala Ser Lys  Asp Pro Ile Tyr Cys  Trp Pro Gly 
    4490                 4495                 4500             


Leu Gly  Gly Tyr Pro Met Ser  Leu Arg Leu Leu Ala  Asn Lys Val 
    4505                 4510                 4515             


Val Pro  Asp Arg Ala Phe Tyr  Gly Ile Gln Ala Tyr  Gly Ile Asn 
    4520                 4525                 4530             


Glu Ser  Glu Ile Pro Phe Ser  Ser Ile Gln Arg Met  Ala Glu Glu 
    4535                 4540                 4545             


Asp Ile  Lys Glu Ile Lys Lys  Ile Gln Pro Glu Gly  Pro Tyr Ile 
    4550                 4555                 4560             


Leu Trp  Gly Tyr Ser Phe Gly  Ala Arg Val Ala Phe  Glu Val Ala 
    4565                 4570                 4575             


Tyr Gln  Leu Glu Gln Ala Gly  Glu Glu Val Asn Ala  Leu Asn Leu 
    4580                 4585                 4590             


Leu Ala  Pro Gly Ser Pro His  Leu Asp Met Lys Gln  Ala Glu Tyr 
    4595                 4600                 4605             


Met Asp  Lys Gly Ala Glu Phe  Thr Asn Pro Ala Phe  Val Lys Ile 
    4610                 4615                 4620             


Leu Phe  Ser Val Phe Ser Arg  Ser Ile Asn Ser Pro  Met Val Lys 
    4625                 4630                 4635             


Thr Cys  Leu Glu Gln Val Asn  Ser Glu Thr Thr Phe  Ile Asn Phe 
    4640                 4645                 4650             


Ile Cys  Ser Arg Phe Lys Asn  Leu Glu Pro Ser Leu  Val Lys Arg 
    4655                 4660                 4665             


Ile Val  Arg Ile Val Thr Leu  Thr Tyr Asp Phe Lys  Tyr Ser Ile 
    4670                 4675                 4680             


Asp Glu  Leu Tyr His Arg His  Leu Lys Ala Pro Ile  Thr Ile Phe 
    4685                 4690                 4695             


Lys Ala  Asn Arg Asp Asn Asp  Ser Phe Ile Glu Glu  Ser Asp Val 
    4700                 4705                 4710             


Ile Ser  Ser Met Ser Pro Lys  Ile Ile Glu Leu Ile  Ser Asp His 
    4715                 4720                 4725             


Tyr Gln  Leu Leu Glu Ser Glu  Gly Val Ala Glu Ile  Glu Lys Ile 
    4730                 4735                 4740             


Ile 
    


<210>  32
<211>  5777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Valine-Indigoidine-tagged Tripeptide 
       consisting of Phenylalanine, Ornithine and Leucine. Valine is 
       here used as spacer.

<400>  32

Met Leu Ala Asn Gln Ala Asn Leu Ile Asp Asn Lys Arg Glu Leu Glu 
1               5                   10                  15      


Gln His Ala Leu Val Pro Tyr Ala Gln Gly Lys Ser Ile His Gln Leu 
            20                  25                  30          


Phe Glu Glu Gln Ala Glu Ala Phe Pro Asp Arg Val Ala Ile Val Phe 
        35                  40                  45              


Glu Asn Arg Arg Leu Ser Tyr Gln Glu Leu Asn Arg Lys Ala Asn Gln 
    50                  55                  60                  


Leu Ala Arg Ala Leu Leu Glu Lys Gly Val Gln Thr Asp Ser Ile Val 
65                  70                  75                  80  


Gly Val Met Met Glu Lys Ser Ile Glu Asn Val Ile Ala Ile Leu Ala 
                85                  90                  95      


Val Leu Lys Ala Gly Gly Ala Tyr Val Pro Ile Asp Ile Glu Tyr Pro 
            100                 105                 110         


Arg Asp Arg Ile Gln Tyr Ile Leu Gln Asp Ser Gln Thr Lys Ile Val 
        115                 120                 125             


Leu Thr Gln Lys Ser Val Ser Gln Leu Val His Asp Val Gly Tyr Ser 
    130                 135                 140                 


Gly Glu Val Val Val Leu Asp Glu Glu Gln Leu Asp Ala Arg Glu Thr 
145                 150                 155                 160 


Ala Asn Leu His Gln Pro Ser Lys Pro Thr Asp Leu Ala Tyr Val Ile 
                165                 170                 175     


Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Thr Met Leu Glu His 
            180                 185                 190         


Lys Gly Ile Ala Asn Leu Gln Ser Phe Phe Gln Asn Ser Phe Gly Val 
        195                 200                 205             


Thr Glu Gln Asp Arg Ile Gly Leu Phe Ala Ser Met Ser Phe Asp Ala 
    210                 215                 220                 


Ser Val Trp Glu Met Phe Met Ala Leu Leu Ser Gly Ala Ser Leu Tyr 
225                 230                 235                 240 


Ile Leu Ser Lys Gln Thr Ile His Asp Phe Ala Ala Phe Glu His Tyr 
                245                 250                 255     


Leu Ser Glu Asn Glu Leu Thr Ile Ile Thr Leu Pro Pro Thr Tyr Leu 
            260                 265                 270         


Thr His Leu Thr Pro Glu Arg Ile Thr Ser Leu Arg Ile Met Ile Thr 
        275                 280                 285             


Ala Gly Ser Ala Ser Ser Ala Pro Leu Val Asn Lys Trp Lys Asp Lys 
    290                 295                 300                 


Leu Arg Tyr Ile Asn Ala Tyr Gly Pro Thr Glu Thr Ser Ile Cys Ala 
305                 310                 315                 320 


Thr Ile Trp Glu Ala Pro Ser Asn Gln Leu Ser Val Gln Ser Val Pro 
                325                 330                 335     


Ile Gly Lys Pro Ile Gln Asn Thr His Ile Tyr Ile Val Asn Glu Asp 
            340                 345                 350         


Leu Gln Leu Leu Pro Thr Gly Ser Glu Gly Glu Leu Cys Ile Gly Gly 
        355                 360                 365             


Val Gly Leu Ala Arg Gly Tyr Trp Asn Arg Pro Asp Leu Thr Ala Glu 
    370                 375                 380                 


Lys Phe Val Asp Asn Pro Phe Val Pro Gly Glu Lys Met Tyr Arg Thr 
385                 390                 395                 400 


Gly Asp Leu Ala Lys Trp Leu Thr Asp Gly Thr Ile Glu Phe Leu Gly 
                405                 410                 415     


Arg Ile Asp His Gln Val Lys Ile Arg Gly His Arg Ile Glu Leu Gly 
            420                 425                 430         


Glu Ile Glu Ser Val Leu Leu Ala His Glu His Ile Thr Glu Ala Val 
        435                 440                 445             


Val Ile Ala Arg Glu Asp Gln His Ala Gly Gln Tyr Leu Cys Ala Tyr 
    450                 455                 460                 


Tyr Ile Ser Gln Gln Glu Ala Thr Pro Ala Gln Leu Arg Asp Tyr Ala 
465                 470                 475                 480 


Ala Gln Lys Leu Pro Ala Tyr Met Leu Pro Ser Tyr Phe Val Lys Leu 
                485                 490                 495     


Asp Lys Met Pro Leu Thr Pro Asn Asp Lys Ile Asp Arg Lys Ala Leu 
            500                 505                 510         


Pro Glu Pro Asp Leu Thr Ala Asn Gln Ser Gln Ala Ala Tyr His Pro 
        515                 520                 525             


Pro Arg Thr Glu Thr Glu Ser Ile Leu Val Ser Ile Trp Gln Asn Val 
    530                 535                 540                 


Leu Gly Ile Glu Lys Ile Gly Ile Arg Asp Asn Phe Tyr Ser Leu Gly 
545                 550                 555                 560 


Gly Asp Ser Ile Gln Ala Ile Gln Val Val Ala Arg Leu His Ser Tyr 
                565                 570                 575     


Gln Leu Lys Leu Glu Thr Lys Asp Leu Leu Asn Tyr Pro Thr Ile Glu 
            580                 585                 590         


Gln Val Ala Leu Phe Val Lys Ser Thr Thr Arg Lys Ser Asp Gln Gly 
        595                 600                 605             


Ile Ile Ala Gly Asn Val Pro Leu Thr Pro Ile Gln Lys Trp Phe Phe 
    610                 615                 620                 


Gly Lys Asn Phe Thr Asn Thr Gly His Trp Asn Gln Ser Ser Val Leu 
625                 630                 635                 640 


Tyr Arg Pro Glu Gly Phe Asp Pro Lys Val Ile Gln Ser Val Met Asp 
                645                 650                 655     


Lys Ile Ile Glu His His Asp Ala Leu Arg Met Val Tyr Gln His Glu 
            660                 665                 670         


Asn Gly Asn Val Val Gln His Asn Arg Gly Leu Gly Gly Gln Leu Tyr 
        675                 680                 685             


Asp Phe Phe Ser Tyr Asn Leu Thr Ala Gln Pro Asp Val Gln Gln Ala 
    690                 695                 700                 


Ile Glu Ala Glu Thr Gln Arg Leu His Ser Ser Met Asn Leu Gln Glu 
705                 710                 715                 720 


Gly Pro Leu Val Lys Val Ala Leu Phe Gln Thr Leu His Gly Asp His 
                725                 730                 735     


Leu Phe Leu Ala Ile His His Leu Val Val Asp Gly Ile Ser Trp Arg 
            740                 745                 750         


Ile Leu Phe Glu Asp Leu Ala Thr Gly Tyr Ala Gln Ala Leu Ala Gly 
        755                 760                 765             


Gln Ala Ile Ser Leu Pro Glu Lys Thr Asp Ser Phe Gln Ser Trp Ser 
    770                 775                 780                 


Gln Trp Leu Gln Glu Tyr Ala Asn Glu Ala Asp Leu Leu Ser Glu Ile 
785                 790                 795                 800 


Pro Tyr Trp Glu Ser Leu Glu Ser Gln Ala Lys Asn Val Ser Leu Pro 
                805                 810                 815     


Lys Asp Tyr Glu Val Thr Asp Cys Lys Gln Lys Ser Val Arg Asn Met 
            820                 825                 830         


Arg Ile Arg Leu His Pro Glu Glu Thr Glu Gln Leu Leu Lys His Ala 
        835                 840                 845             


Asn Gln Ala Tyr Gln Thr Glu Ile Asn Asp Leu Leu Leu Ala Ala Leu 
    850                 855                 860                 


Gly Leu Ala Phe Ala Glu Trp Ser Lys Leu Ala Gln Ile Val Ile His 
865                 870                 875                 880 


Leu Glu Gly His Gly Arg Glu Asp Ile Ile Glu Gln Ala Asn Val Ala 
                885                 890                 895     


Arg Thr Val Gly Trp Phe Thr Ser Gln Tyr Pro Val Leu Leu Asp Leu 
            900                 905                 910         


Lys Gln Thr Ala Pro Leu Ser Asp Tyr Ile Lys Leu Thr Lys Glu Asn 
        915                 920                 925             


Met Arg Lys Ile Pro Arg Lys Gly Ile Gly Tyr Asp Ile Leu Lys His 
    930                 935                 940                 


Val Thr Leu Pro Glu Asn Arg Gly Ser Leu Ser Phe Arg Val Gln Pro 
945                 950                 955                 960 


Glu Val Thr Phe Asn Tyr Leu Gly Gln Phe Asp Ala Asp Met Arg Thr 
                965                 970                 975     


Glu Leu Phe Thr Arg Ser Pro Tyr Ser Gly Gly Asn Thr Leu Gly Ala 
            980                 985                 990         


Asp Gly Lys Asn Asn Leu Ser Pro  Glu Ser Glu Val Tyr  Thr Ala Leu 
        995                 1000                 1005             


Asn Ile  Thr Gly Leu Ile Glu  Gly Gly Glu Leu Val  Leu Thr Phe 
    1010                 1015                 1020             


Ser Tyr  Ser Ser Glu Gln Tyr  Arg Glu Glu Ser Ile  Gln Gln Leu 
    1025                 1030                 1035             


Ser Gln  Ser Tyr Gln Lys His  Leu Leu Ala Ile Ile  Ala His Cys 
    1040                 1045                 1050             


Thr Glu  Lys Lys Glu Val Glu  Arg Thr Ala His Ile  Ala Glu Ser 
    1055                 1060                 1065             


Ala Phe  Glu Gln Phe Glu Thr  Ile Gln Pro Val Glu  Pro Ala Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Val Ser Phe Ala  Gln Lys Arg Met Tyr  Ile Leu His 
    1085                 1090                 1095             


Gln Phe  Glu Gly Ser Gly Ile  Ser Tyr Asn Val Pro  Ser Val Leu 
    1100                 1105                 1110             


Val Leu  Glu Gly Lys Leu Asp  Tyr Asp Arg Phe Ala  Ala Ala Ile 
    1115                 1120                 1125             


Gln Ser  Leu Val Lys Arg His  Glu Ser Leu Arg Thr  Ser Phe His 
    1130                 1135                 1140             


Ser Val  Asn Gly Glu Pro Leu  Gln Arg Val His Pro  Asp Val Glu 
    1145                 1150                 1155             


Leu Pro  Val Arg Leu Leu Glu  Ala Thr Glu Asp Gln  Ser Glu Ser 
    1160                 1165                 1170             


Leu Ile  Gln Glu Leu Ile Gln  Pro Phe Asp Leu Glu  Ile Ala Pro 
    1175                 1180                 1185             


Leu Phe  Arg Val Asn Leu Ile  Lys Leu Gly Ala Glu  Arg His Leu 
    1190                 1195                 1200             


Phe Phe  Met Asp Met His His  Ile Ile Ser Asp Gly  Val Ser Leu 
    1205                 1210                 1215             


Ala Val  Ile Val Glu Glu Ile  Ala Ser Leu Tyr Ala  Gly Lys Gln 
    1220                 1225                 1230             


Leu Ser  Asp Leu Arg Ile Gln  Tyr Lys Asp Phe Ala  Val Trp Gln 
    1235                 1240                 1245             


Thr Lys  Leu Ala Gln Ser Asp  Arg Phe Gln Lys Gln  Glu Asp Phe 
    1250                 1255                 1260             


Trp Thr  Arg Thr Phe Ala Gly  Glu Ile Pro Leu Leu  Asn Leu Pro 
    1265                 1270                 1275             


His Asp  Tyr Pro Arg Pro Ser  Val Gln Ser Phe Asp  Gly Asp Thr 
    1280                 1285                 1290             


Val Ala  Leu Gly Thr Gly His  His Leu Leu Glu Gln  Leu Arg Lys 
    1295                 1300                 1305             


Leu Ala  Ala Glu Thr Gly Thr  Thr Leu Phe Met Val  Leu Leu Ala 
    1310                 1315                 1320             


Ala Tyr  His Val Leu Leu Ser  Lys Tyr Ala Gly Gln  Glu Glu Ile 
    1325                 1330                 1335             


Val Val  Gly Thr Pro Ile Ala  Gly Arg Ser His Ala  Asp Val Glu 
    1340                 1345                 1350             


Arg Ile  Val Gly Met Phe Val  Asn Thr Leu Ala Leu  Lys Asn Thr 
    1355                 1360                 1365             


Ala Ala  Gly Ser Leu Ser Phe  Arg Ala Phe Leu Glu  Asp Val Lys 
    1370                 1375                 1380             


Gln Asn  Ala Leu His Ala Phe  Glu His Gln Asp Tyr  Pro Phe Glu 
    1385                 1390                 1395             


His Leu  Val Glu Lys Leu Gln  Val Arg Arg Asp Leu  Ser Arg Asn 
    1400                 1405                 1410             


Pro Leu  Phe Asp Thr Met Phe  Ser Leu Gly Leu Ala  Glu Ser Ala 
    1415                 1420                 1425             


Glu Gly  Glu Val Ala Asp Leu  Lys Val Ser Pro Tyr  Pro Val Asn 
    1430                 1435                 1440             


Gly His  Ile Ala Lys Phe Asp  Leu Ser Leu Asp Ala  Met Glu Lys 
    1445                 1450                 1455             


Gln Asp  Gly Leu Leu Val Gln  Phe Ser Tyr Cys Thr  Lys Leu Phe 
    1460                 1465                 1470             


Ala Lys  Glu Thr Val Asp Arg  Leu Ala Ala His Tyr  Val Gln Leu 
    1475                 1480                 1485             


Leu Gln  Thr Ile Thr Ala Asp  Pro Asp Ile Glu Leu  Ala Arg Ile 
    1490                 1495                 1500             


Ser Val  Leu Ser Lys Ala Glu  Thr Glu His Met Leu  His Ser Phe 
    1505                 1510                 1515             


Leu Ala  Thr Lys Thr Ala Tyr  Pro Thr Asp Lys Thr  Phe Gln Lys 
    1520                 1525                 1530             


Leu Phe  Glu Glu Gln Val Glu  Lys Thr Pro Asn Glu  Ile Ala Val 
    1535                 1540                 1545             


Leu Phe  Gly Asn Glu Gln Leu  Thr Tyr Gln Glu Leu  Asn Ala Lys 
    1550                 1555                 1560             


Ala Asn  Gln Leu Ala Arg Val  Leu Arg Arg Lys Gly  Val Lys Pro 
    1565                 1570                 1575             


Glu Ser  Thr Val Gly Ile Leu  Val Asp Arg Ser Leu  Tyr Met Val 
    1580                 1585                 1590             


Ile Gly  Met Leu Ala Val Leu  Lys Ala Gly Gly Thr  Phe Val Pro 
    1595                 1600                 1605             


Ile Asp  Pro Asp Tyr Pro Leu  Glu Arg Gln Ala Phe  Met Leu Glu 
    1610                 1615                 1620             


Asp Ser  Glu Ala Lys Leu Leu  Leu Thr Leu Gln Lys  Met Asn Ser 
    1625                 1630                 1635             


Gln Val  Ala Phe Pro Tyr Glu  Thr Phe Tyr Leu Asp  Thr Glu Thr 
    1640                 1645                 1650             


Val Asp  Gln Glu Glu Thr Gly  Asn Leu Glu His Val  Ala Gln Pro 
    1655                 1660                 1665             


Glu Asn  Val Ala Tyr Ile Ile  Tyr Thr Ser Gly Thr  Thr Gly Lys 
    1670                 1675                 1680             


Pro Lys  Gly Val Val Ile Glu  His Arg Ser Tyr Ala  Asn Val Ala 
    1685                 1690                 1695             


Phe Ala  Trp Lys Asp Glu Tyr  His Leu Asp Ser Phe  Pro Val Arg 
    1700                 1705                 1710             


Leu Leu  Gln Met Ala Ser Phe  Ala Phe Asp Val Ser  Thr Gly Asp 
    1715                 1720                 1725             


Phe Ala  Arg Ala Leu Leu Thr  Gly Gly Gln Leu Val  Ile Cys Pro 
    1730                 1735                 1740             


Asn Gly  Val Lys Met Asp Pro  Ala Ser Leu Tyr Glu  Thr Ile Arg 
    1745                 1750                 1755             


Arg His  Glu Ile Thr Ile Phe  Glu Ala Thr Pro Ala  Leu Ile Met 
    1760                 1765                 1770             


Pro Leu  Met His Tyr Val Tyr  Glu Asn Glu Leu Asp  Met Ser Gln 
    1775                 1780                 1785             


Met Lys  Leu Leu Ile Leu Gly  Ala Asp Ser Cys Pro  Ala Glu Asp 
    1790                 1795                 1800             


Phe Lys  Thr Leu Leu Ala Arg  Phe Gly Gln Lys Met  Arg Ile Ile 
    1805                 1810                 1815             


Asn Ser  Tyr Gly Val Thr Glu  Ala Cys Ile Asp Thr  Ser Tyr Tyr 
    1820                 1825                 1830             


Glu Glu  Thr Asp Val Thr Ala  Ile Arg Ser Gly Thr  Val Pro Ile 
    1835                 1840                 1845             


Gly Lys  Pro Leu Pro Asn Met  Thr Met Tyr Val Val  Asp Ala His 
    1850                 1855                 1860             


Leu Asn  Leu Gln Pro Val Gly  Val Val Gly Glu Leu  Cys Ile Gly 
    1865                 1870                 1875             


Gly Ala  Gly Val Ala Arg Gly  Tyr Leu Asn Arg Pro  Glu Leu Thr 
    1880                 1885                 1890             


Glu Glu  Lys Phe Val Pro Asn  Pro Phe Ala Pro Gly  Glu Arg Leu 
    1895                 1900                 1905             


Tyr Arg  Thr Gly Asp Leu Ala  Lys Trp Arg Ala Asp  Gly Asn Val 
    1910                 1915                 1920             


Glu Phe  Leu Gly Arg Asn Asp  His Gln Val Lys Ile  Arg Gly Val 
    1925                 1930                 1935             


Arg Ile  Glu Leu Gly Glu Ile  Glu Thr Gln Leu Arg  Lys Leu Asp 
    1940                 1945                 1950             


Gly Ile  Thr Glu Ala Val Val  Val Ala Arg Glu Asp  Arg Gly Gln 
    1955                 1960                 1965             


Glu Lys  Glu Leu Cys Ala Tyr  Val Val Ala Asp His  Lys Leu Asp 
    1970                 1975                 1980             


Thr Ala  Glu Leu Arg Ala Asn  Leu Leu Lys Glu Leu  Pro Gln Ala 
    1985                 1990                 1995             


Met Ile  Pro Ala Tyr Phe Val  Thr Leu Asp Ala Leu  Pro Leu Thr 
    2000                 2005                 2010             


Ala Asn  Gly Lys Val Asp Arg  Arg Ser Leu Pro Ala  Pro Asp Val 
    2015                 2020                 2025             


Thr Met  Leu Arg Thr Thr Glu  Tyr Val Ala Pro Arg  Ser Val Trp 
    2030                 2035                 2040             


Glu Ala  Arg Leu Ala Gln Val  Trp Glu Gln Val Leu  Asn Val Pro 
    2045                 2050                 2055             


Gln Val  Gly Ala Leu Asp Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    2060                 2065                 2070             


Leu Arg  Ala Met Arg Val Leu  Ser Ser Met His Asn  Glu Tyr Gln 
    2075                 2080                 2085             


Val Asp  Ile Pro Leu Arg Ile  Leu Phe Glu Lys Pro  Thr Ile Gln 
    2090                 2095                 2100             


Glu Leu  Ala Ala Phe Ile Glu  Glu Thr Ala Lys Gly  Asn Val Phe 
    2105                 2110                 2115             


Ser Ile  Glu Pro Val Gln Lys  Gln Ala Tyr Tyr Pro  Val Ser Ser 
    2120                 2125                 2130             


Ala Gln  Lys Arg Met Tyr Ile  Leu Asp Gln Phe Glu  Gly Val Gly 
    2135                 2140                 2145             


Ile Ser  Tyr Asn Met Pro Ser  Thr Met Leu Ile Glu  Gly Lys Leu 
    2150                 2155                 2160             


Glu Arg  Thr Arg Val Glu Ala  Ala Phe Gln Arg Leu  Ile Ala Arg 
    2165                 2170                 2175             


His Glu  Ser Leu Arg Thr Ser  Phe Ala Val Val Asn  Gly Glu Pro 
    2180                 2185                 2190             


Val Gln  Asn Ile His Glu Asp  Val Pro Phe Ala Leu  Ala Tyr Ser 
    2195                 2200                 2205             


Glu Val  Thr Glu Gln Glu Ala  Arg Glu Leu Val Ser  Ser Leu Val 
    2210                 2215                 2220             


Gln Pro  Phe Asp Leu Glu Val  Ala Pro Leu Ile Arg  Val Ser Leu 
    2225                 2230                 2235             


Leu Lys  Ile Gly Glu Asp Arg  Tyr Val Leu Phe Thr  Asp Met His 
    2240                 2245                 2250             


His Ser  Ile Ser Asp Gly Val  Ser Ser Gly Ile Leu  Leu Ala Glu 
    2255                 2260                 2265             


Trp Val  Gln Leu Tyr Gln Gly  Asp Val Leu Pro Glu  Leu Arg Ile 
    2270                 2275                 2280             


Gln Tyr  Lys Asp Phe Ala Val  Trp Gln Gln Glu Phe  Ser Gln Ser 
    2285                 2290                 2295             


Ala Ala  Phe His Lys Gln Glu  Ala Tyr Trp Leu Gln  Thr Phe Ala 
    2300                 2305                 2310             


Asp Asp  Ile Pro Val Leu Asn  Leu Pro Thr Asp Phe  Thr Arg Pro 
    2315                 2320                 2325             


Ser Thr  Gln Ser Phe Ala Gly  Asp Gln Cys Thr Ile  Gly Ala Gly 
    2330                 2335                 2340             


Lys Ala  Leu Thr Glu Gly Leu  His Gln Leu Ala Gln  Ala Thr Gly 
    2345                 2350                 2355             


Thr Thr  Leu Tyr Met Val Leu  Leu Ala Ala Tyr Asn  Val Leu Leu 
    2360                 2365                 2370             


Ala Lys  Tyr Ala Gly Gln Glu  Asp Ile Ile Val Gly  Thr Pro Ile 
    2375                 2380                 2385             


Thr Gly  Arg Ser His Ala Asp  Leu Glu Pro Ile Val  Gly Met Phe 
    2390                 2395                 2400             


Val Asn  Thr Leu Ala Met Arg  Asn Lys Pro Gln Arg  Glu Lys Thr 
    2405                 2410                 2415             


Phe Ser  Glu Phe Leu Gln Glu  Val Lys Gln Asn Ala  Leu Asp Ala 
    2420                 2425                 2430             


Tyr Gly  His Gln Asp Tyr Pro  Phe Glu Glu Leu Val  Glu Lys Leu 
    2435                 2440                 2445             


Ala Ile  Ala Arg Asp Leu Ser  Arg Asn Pro Leu Phe  Asp Thr Val 
    2450                 2455                 2460             


Phe Thr  Phe Gln Asn Ser Thr  Glu Glu Val Met Thr  Leu Pro Glu 
    2465                 2470                 2475             


Cys Thr  Leu Ala Pro Phe Met  Thr Asp Glu Thr Gly  Gln His Ala 
    2480                 2485                 2490             


Lys Phe  Asp Leu Thr Phe Ser  Ala Thr Glu Glu Arg  Glu Glu Met 
    2495                 2500                 2505             


Thr Ile  Gly Val Glu Tyr Ser  Thr Ser Leu Phe Thr  Arg Glu Thr 
    2510                 2515                 2520             


Met Glu  Arg Phe Ser Arg His  Phe Leu Thr Ile Ala  Ala Ser Ile 
    2525                 2530                 2535             


Val Gln  Asn Pro His Ile Arg  Leu Gly Glu Ile Asp  Met Leu Leu 
    2540                 2545                 2550             


Pro Glu  Glu Lys Gln Gln Ile  Leu Ala Gly Phe Asn  Asp Thr Ala 
    2555                 2560                 2565             


Val Ser  Tyr Ala Leu Asp Lys  Thr Leu His Gln Leu  Phe Glu Glu 
    2570                 2575                 2580             


Gln Val  Asp Lys Thr Pro Asp  Gln Ala Ala Leu Leu  Phe Ser Glu 
    2585                 2590                 2595             


Gln Ser  Leu Thr Tyr Ser Glu  Leu Asn Glu Arg Ala  Asn Arg Leu 
    2600                 2605                 2610             


Ala Arg  Val Leu Arg Ala Lys  Gly Val Gly Pro Asp  Arg Leu Val 
    2615                 2620                 2625             


Ala Ile  Met Ala Glu Arg Ser  Pro Glu Met Val Ile  Gly Ile Leu 
    2630                 2635                 2640             


Gly Ile  Leu Lys Ala Gly Gly  Ala Tyr Val Pro Val  Asp Pro Gly 
    2645                 2650                 2655             


Tyr Pro  Gln Glu Arg Ile Gln  Tyr Leu Leu Glu Asp  Ser Asn Ala 
    2660                 2665                 2670             


Ala Leu  Leu Leu Ser Gln Ala  His Leu Leu Pro Leu  Leu Ala Gln 
    2675                 2680                 2685             


Val Ser  Ser Glu Leu Pro Glu  Cys Leu Asp Leu Asn  Ala Glu Leu 
    2690                 2695                 2700             


Asp Ala  Gly Leu Ser Gly Ser  Asn Leu Pro Ala Val  Asn Gln Pro 
    2705                 2710                 2715             


Thr Asp  Leu Ala Tyr Val Ile  Tyr Thr Ser Gly Thr  Thr Gly Lys 
    2720                 2725                 2730             


Pro Lys  Gly Val Met Ile Pro  His Gln Gly Ile Val  Asn Cys Leu 
    2735                 2740                 2745             


Gln Trp  Arg Arg Asp Glu Tyr  Gly Phe Gly Pro Ser  Asp Lys Ala 
    2750                 2755                 2760             


Leu Gln  Val Phe Ser Phe Ala  Phe Asp Gly Phe Val  Ala Ser Leu 
    2765                 2770                 2775             


Phe Ala  Pro Leu Leu Gly Gly  Ala Thr Cys Val Leu  Pro Gln Glu 
    2780                 2785                 2790             


Ala Ala  Ala Lys Asp Pro Val  Ala Leu Lys Lys Leu  Met Ala Ala 
    2795                 2800                 2805             


Thr Glu  Val Thr His Tyr Tyr  Gly Val Pro Ser Leu  Phe Gln Ala 
    2810                 2815                 2820             


Ile Leu  Asp Cys Ser Thr Thr  Thr Asp Phe Asn Gln  Leu Arg Cys 
    2825                 2830                 2835             


Val Thr  Leu Gly Gly Glu Lys  Leu Pro Val Gln Leu  Val Gln Lys 
    2840                 2845                 2850             


Thr Lys  Glu Lys His Pro Ala  Ile Glu Ile Asn Asn  Glu Tyr Gly 
    2855                 2860                 2865             


Pro Thr  Glu Asn Ser Val Val  Thr Thr Ile Ser Arg  Ser Ile Glu 
    2870                 2875                 2880             


Ala Gly  Gln Ala Ile Thr Ile  Gly Arg Pro Leu Ala  Asn Val Gln 
    2885                 2890                 2895             


Val Tyr  Ile Val Asp Glu Gln  His His Leu Gln Pro  Ile Gly Val 
    2900                 2905                 2910             


Val Gly  Glu Leu Cys Ile Gly  Gly Ala Gly Leu Ala  Arg Gly Tyr 
    2915                 2920                 2925             


Leu Asn  Lys Pro Glu Leu Thr  Ala Glu Lys Phe Val  Ala Asn Pro 
    2930                 2935                 2940             


Phe Arg  Pro Gly Glu Arg Met  Tyr Lys Thr Gly Asp  Leu Val Lys 
    2945                 2950                 2955             


Trp Arg  Thr Asp Gly Thr Ile  Glu Tyr Ile Gly Arg  Ala Asp Glu 
    2960                 2965                 2970             


Gln Val  Lys Val Arg Gly Tyr  Arg Ile Glu Ile Gly  Glu Ile Glu 
    2975                 2980                 2985             


Ser Ala  Val Leu Ala Tyr Gln  Gly Ile Asp Gln Ala  Val Val Val 
    2990                 2995                 3000             


Ala Arg  Asp Asp Asp Ala Thr  Ala Gly Ser Tyr Leu  Cys Ala Tyr 
    3005                 3010                 3015             


Phe Val  Ala Ala Thr Ala Val  Ser Val Ser Gly Leu  Arg Ser His 
    3020                 3025                 3030             


Leu Ala  Lys Glu Leu Pro Ala  Tyr Met Ile Pro Ser  Tyr Phe Val 
    3035                 3040                 3045             


Glu Leu  Asp Gln Leu Pro Leu  Ser Ala Asn Gly Lys  Val Asp Arg 
    3050                 3055                 3060             


Lys Ala  Leu Pro Lys Pro Gln  Gln Ser Asp Ala Thr  Thr Arg Glu 
    3065                 3070                 3075             


Tyr Val  Ala Pro Arg Asn Ala  Thr Glu Gln Gln Leu  Ala Ala Ile 
    3080                 3085                 3090             


Trp Gln  Glu Val Leu Gly Val  Glu Pro Ile Gly Ile  Thr Asp Gln 
    3095                 3100                 3105             


Phe Phe  Glu Leu Gly Gly His  Ser Leu Lys Ala Thr  Leu Leu Ile 
    3110                 3115                 3120             


Ala Lys  Val Tyr Glu Tyr Met  Gln Ile Glu Leu Pro  Leu Asn Leu 
    3125                 3130                 3135             


Ile Phe  Gln Tyr Pro Thr Ile  Glu Lys Val Ala Asp  Phe Ile Thr 
    3140                 3145                 3150             


Thr Ser  Gly Lys Glu Thr Tyr  Val Pro Ile Glu Pro  Ala Pro Leu 
    3155                 3160                 3165             


Gln Glu  Tyr Tyr Pro Val Ser  Ser Ala Gln Lys Arg  Met Tyr Val 
    3170                 3175                 3180             


Leu Arg  Gln Phe Ala Asp Thr  Gly Thr Val Tyr Asn  Met Pro Ser 
    3185                 3190                 3195             


Ala Leu  Tyr Ile Glu Gly Asp  Leu Asp Arg Lys Arg  Phe Glu Ala 
    3200                 3205                 3210             


Ala Ile  His Gly Leu Val Glu  Arg His Glu Ser Leu  Arg Thr Ser 
    3215                 3220                 3225             


Phe His  Thr Val Asn Gly Glu  Pro Val Gln Arg Val  His Glu His 
    3230                 3235                 3240             


Val Glu  Leu Asn Val Gln Tyr  Ala Glu Val Thr Glu  Ala Gln Val 
    3245                 3250                 3255             


Glu Pro  Thr Val Glu Ser Phe  Val Gln Ala Phe Asp  Leu Thr Lys 
    3260                 3265                 3270             


Ala Pro  Leu Leu Arg Val Gly  Leu Phe Lys Leu Ala  Ala Lys Arg 
    3275                 3280                 3285             


His Leu  Phe Leu Leu Asp Met  His His Ile Ile Ser  Asp Gly Val 
    3290                 3295                 3300             


Ser Ala  Gly Ile Ile Met Glu  Glu Phe Ser Lys Leu  Tyr Arg Gly 
    3305                 3310                 3315             


Glu Glu  Leu Pro Ala Leu Ser  Val His Tyr Lys Asp  Phe Ala Val 
    3320                 3325                 3330             


Trp Gln  Ser Glu Leu Phe Gln  Ser Asp Val Tyr Thr  Glu His Glu 
    3335                 3340                 3345             


Asn Tyr  Trp Leu Asn Ala Phe  Ser Gly Asp Ile Pro  Val Leu Asn 
    3350                 3355                 3360             


Leu Pro  Ala Asp Phe Ser Arg  Pro Leu Thr Gln Ser  Phe Glu Gly 
    3365                 3370                 3375             


Asp Cys  Val Ser Phe Gln Ala  Asp Lys Ala Leu Leu  Asp Asp Leu 
    3380                 3385                 3390             


His Lys  Leu Ala Gln Glu Ser  Gln Ser Thr Leu Phe  Met Val Leu 
    3395                 3400                 3405             


Leu Ala  Ala Tyr Asn Val Leu  Leu Ala Lys Tyr Ser  Gly Gln Glu 
    3410                 3415                 3420             


Asp Ile  Val Val Gly Thr Pro  Ile Ala Gly Arg Ser  His Ala Asp 
    3425                 3430                 3435             


Ile Glu  Asn Val Leu Gly Met  Phe Val Asn Thr Leu  Ala Leu Arg 
    3440                 3445                 3450             


Asn Tyr  Pro Val Glu Thr Lys  His Phe Gln Ala Phe  Leu Glu Glu 
    3455                 3460                 3465             


Val Lys  Gln Asn Thr Leu Gln  Ala Tyr Ala His Gln  Asp Tyr Pro 
    3470                 3475                 3480             


Phe Glu  Ala Leu Val Glu Lys  Leu Asp Ile Gln Arg  Asp Leu Ser 
    3485                 3490                 3495             


Arg Asn  Pro Leu Phe Asp Thr  Met Phe Ile Leu Gln  Asn Leu Asp 
    3500                 3505                 3510             


Gln Lys  Ala Tyr Glu Leu Asp  Gly Leu Lys Leu Glu  Ala Tyr Pro 
    3515                 3520                 3525             


Ala Gln  Ala Gly Asn Ala Lys  Phe Asp Leu Thr Leu  Glu Ala His 
    3530                 3535                 3540             


Glu Asp  Glu Thr Gly Ile His  Phe Ala Leu Val Tyr  Ser Thr Lys 
    3545                 3550                 3555             


Leu Phe  Gln Arg Glu Ser Ile  Glu Arg Met Ala Gly  His Phe Leu 
    3560                 3565                 3570             


Gln Val  Leu Arg Gln Val Val  Ala Asp Gln Ala Thr  Ala Leu Arg 
    3575                 3580                 3585             


Glu Ile  Ser Leu Leu Ser Glu  Glu Glu Arg Arg Ile  Val Thr Val 
    3590                 3595                 3600             


Asp Phe  Asn Asn Thr Phe Ala  Tyr Pro Arg Asp Leu  Thr Ile Gln 
    3605                 3610                 3615             


Glu Leu  Phe Glu Gln Gln Ala  Ala Lys Thr Pro Glu  His Ala Ala 
    3620                 3625                 3630             


Val Val  Met Asp Gly Gln Met  Leu Thr Tyr Arg Glu  Leu Asn Glu 
    3635                 3640                 3645             


Lys Ala  Asn Gln Leu Ala His  Val Leu Arg Gln Asn  Gly Val Gly 
    3650                 3655                 3660             


Lys Glu  Ser Ile Val Gly Leu  Leu Ala Asp Arg Ser  Leu Glu Met 
    3665                 3670                 3675             


Ile Thr  Gly Ile Met Gly Ile  Leu Lys Ala Gly Gly  Ala Tyr Leu 
    3680                 3685                 3690             


Gly Leu  Asp Pro Glu His Pro  Ser Glu Arg Leu Ala  Tyr Met Leu 
    3695                 3700                 3705             


Glu Asp  Gly Gly Val Lys Val  Val Leu Val Gln Lys  His Leu Leu 
    3710                 3715                 3720             


Pro Leu  Val Gly Glu Gly Leu  Met Pro Ile Val Leu  Glu Glu Glu 
    3725                 3730                 3735             


Ser Leu  Arg Pro Glu Asp Cys  Gly Asn Pro Ala Ile  Val Asn Gly 
    3740                 3745                 3750             


Ala Ser  Asp Leu Ala Tyr Val  Met Tyr Thr Ser Gly  Ser Thr Gly 
    3755                 3760                 3765             


Lys Pro  Lys Gly Val Met Val  Glu His Arg Asn Val  Thr Arg Leu 
    3770                 3775                 3780             


Val Met  His Thr Asn Tyr Val  Gln Val Arg Glu Ser  Asp Arg Met 
    3785                 3790                 3795             


Ile Gln  Thr Gly Ala Ile Gly  Phe Asp Ala Met Thr  Phe Glu Ile 
    3800                 3805                 3810             


Phe Gly  Ala Leu Leu His Gly  Ala Ser Leu Tyr Leu  Val Ser Lys 
    3815                 3820                 3825             


Asp Val  Leu Leu Asp Ala Glu  Lys Leu Gly Asp Phe  Leu Arg Thr 
    3830                 3835                 3840             


Asn Gln  Ile Thr Thr Met Trp  Leu Thr Ser Pro Leu  Phe Asn Gln 
    3845                 3850                 3855             


Leu Ser  Gln Asp Asn Pro Ala  Met Phe Asp Ser Leu  Arg Ala Leu 
    3860                 3865                 3870             


Ile Val  Gly Gly Glu Ala Leu  Ser Pro Lys His Ile  Asn Arg Val 
    3875                 3880                 3885             


Lys Ser  Ala Leu Pro Asp Leu  Glu Ile Trp Asn Gly  Tyr Gly Pro 
    3890                 3895                 3900             


Thr Glu  Asn Thr Thr Phe Ser  Thr Cys Tyr Leu Ile  Glu Gln His 
    3905                 3910                 3915             


Phe Glu  Glu Gln Ile Pro Ile  Gly Lys Pro Ile Ala  Asn Ser Thr 
    3920                 3925                 3930             


Ala Tyr  Ile Val Asp Gly Asn  Asn Gln Pro Gln Pro  Ile Gly Val 
    3935                 3940                 3945             


Pro Gly  Glu Leu Cys Val Gly  Gly Asp Gly Val Ala  Arg Gly Tyr 
    3950                 3955                 3960             


Val Asn  Lys Pro Glu Leu Thr  Ala Glu Lys Phe Val  Pro Asn Pro 
    3965                 3970                 3975             


Phe Ala  Pro Gly Glu Thr Met  Tyr Arg Thr Gly Asp  Leu Ala Arg 
    3980                 3985                 3990             


Trp Leu  Pro Asp Gly Thr Ile  Glu Tyr Leu Gly Arg  Ile Asp Gln 
    3995                 4000                 4005             


Gln Val  Lys Ile Arg Gly Tyr  Arg Ile Glu Leu Gly  Glu Ile Glu 
    4010                 4015                 4020             


Thr Val  Leu Ser Gln Gln Ala  Gln Val Lys Glu Ala  Val Val Ala 
    4025                 4030                 4035             


Val Ile  Glu Glu Ala Asn Gly  Gln Lys Ala Leu Cys  Ala Tyr Phe 
    4040                 4045                 4050             


Val Pro  Glu Gln Ala Val Asp  Ala Ala Glu Leu Arg  Glu Ala Met 
    4055                 4060                 4065             


Ser Lys  Gln Leu Pro Gly Tyr  Met Val Pro Ala Tyr  Tyr Val Gln 
    4070                 4075                 4080             


Met Glu  Lys Leu Pro Leu Thr  Ala Asn Gly Lys Val  Asp Arg Arg 
    4085                 4090                 4095             


Ala Leu  Pro Gln Pro Ser Gly  Glu Arg Thr Thr Gly  Ser Ala Phe 
    4100                 4105                 4110             


Val Ala  Ala Gln Asn Asp Thr  Glu Ala Lys Leu Gln  Gln Ile Trp 
    4115                 4120                 4125             


Gln Glu  Val Leu Gly Ile Pro  Ala Ile Gly Ile His  Asp Asn Phe 
    4130                 4135                 4140             


Phe Glu  Ile Gly Gly His Ser  Leu Lys Ala Met Asn  Val Ile Thr 
    4145                 4150                 4155             


Gln Val  His Lys Thr Phe Gln  Val Glu Leu Pro Leu  Lys Ala Leu 
    4160                 4165                 4170             


Phe Ala  Thr Pro Thr Ile His  Glu Leu Ala Ala His  Ile Ser Glu 
    4175                 4180                 4185             


Lys Thr  Glu Tyr Thr Ala Ile  Gln Pro Val Ala Ala  Gln Glu Phe 
    4190                 4195                 4200             


Tyr Pro  Val Ser Ser Ala Gln  Lys Arg Met Tyr Ile  Leu Gln Gln 
    4205                 4210                 4215             


Phe Glu  Gly Asn Gly Ile Ser  Tyr Asn Ile Ser Gly  Ala Ile Leu 
    4220                 4225                 4230             


Leu Glu  Gly Lys Leu Asp Tyr  Ala Arg Phe Ala Ser  Ala Val Gln 
    4235                 4240                 4245             


Gln Leu  Ala Glu Arg His Glu  Ala Leu Arg Thr Ser  Phe His Arg 
    4250                 4255                 4260             


Ile Asp  Gly Glu Pro Val Gln  Lys Val His Glu Glu  Val Glu Val 
    4265                 4270                 4275             


Pro Leu  Phe Met Leu Glu Ala  Pro Glu Asp Gln Ala  Glu Lys Ile 
    4280                 4285                 4290             


Met Arg  Glu Phe Val Arg Pro  Phe Asp Leu Gly Val  Ala Pro Leu 
    4295                 4300                 4305             


Met Arg  Thr Gly Leu Leu Lys  Leu Gly Lys Asp Arg  His Leu Phe 
    4310                 4315                 4320             


Leu Leu  Asp Met His His Ile  Ile Ser Asp Gly Val  Ser Ser Gln 
    4325                 4330                 4335             


Ile Leu  Leu Arg Glu Phe Ala  Glu Leu Tyr Gln Gly  Ala Asp Leu 
    4340                 4345                 4350             


Gln Pro  Leu Ser Leu Gln Tyr  Lys Asp Phe Ala Ala  Trp Gln Asn 
    4355                 4360                 4365             


Glu Leu  Phe Gln Thr Glu Ala  Tyr Lys Lys Gln Glu  Gln His Trp 
    4370                 4375                 4380             


Leu Asn  Thr Phe Ala Asp Glu  Ile Pro Leu Leu Asn  Leu Pro Thr 
    4385                 4390                 4395             


Asp Tyr  Pro Arg Pro Ser Val  Gln Ser Phe Ala Gly  Asp Leu Val 
    4400                 4405                 4410             


Leu Phe  Ala Ala Gly Lys Glu  Leu Leu Glu Arg Leu  Gln Gln Val 
    4415                 4420                 4425             


Ala Ser  Glu Thr Gly Thr Thr  Leu Tyr Met Ile Leu  Leu Ala Ala 
    4430                 4435                 4440             


Tyr Asn  Val Leu Leu Ser Lys  Tyr Thr Gly Gln Glu  Asp Ile Ile 
    4445                 4450                 4455             


Val Gly  Thr Pro Val Ala Gly  Arg Ser His Ala Asp  Val Glu Asn 
    4460                 4465                 4470             


Ile Met  Gly Ile Phe Val Asn  Thr Leu Ala Leu Arg  Asn Gln Pro 
    4475                 4480                 4485             


Ala Ser  Ser Lys Thr Met Leu  Glu Asn Asn Ile Thr  Gln Cys Asp 
    4490                 4495                 4500             


Ser Ile  Asn Asp Val Tyr Leu  Lys Glu Glu Ala Ile  Thr Leu Met 
    4505                 4510                 4515             


Asp Met  Leu Glu Ser Gln Leu  Lys His Gln Ala Asp  Gly Tyr Val 
    4520                 4525                 4530             


Val Ile  Asp Gln Glu Glu Ser  Leu Ser Tyr Ala Asp  Phe Tyr Leu 
    4535                 4540                 4545             


Arg Val  Lys Glu Ile Gly Tyr  Cys Leu Ser Glu Ile  Ser Ser Lys 
    4550                 4555                 4560             


Asn Ser  Val Gly Ile Gly Leu  Phe Cys Asp Pro Ser  Ile Asp Leu 
    4565                 4570                 4575             


Ile Cys  Gly Ala Trp Gly Ile  Leu Ser Ala Asp Lys  Ala Tyr Leu 
    4580                 4585                 4590             


Pro Leu  Ser Pro Asp Tyr Pro  Thr Glu Arg Leu Lys  Tyr Met Ile 
    4595                 4600                 4605             


Glu Asp  Ser Gly Ile Asp Val  Ile Phe Thr Gln Ser  His Leu Lys 
    4610                 4615                 4620             


Ala Gln  Leu Gln Asp Ile Ala  Pro Lys Ser Val Leu  Ile Met Thr 
    4625                 4630                 4635             


Pro Glu  Asp Val Ala Leu Thr  Ile Lys Thr Arg Thr  Ile Glu Asp 
    4640                 4645                 4650             


Ile Leu  Gly Thr Val Gln Val  Pro Lys Pro Thr Ser  Leu Ala Tyr 
    4655                 4660                 4665             


Ile Ile  Tyr Thr Ser Gly Ser  Thr Gly Lys Pro Lys  Gly Val Met 
    4670                 4675                 4680             


Ile Glu  His His Ser Ile Val  Asn Gln Met Arg Phe  Leu Ala Lys 
    4685                 4690                 4695             


Ala Phe  Lys Leu Gly Cys His  Ser Arg Ile Leu Gln  Lys Thr Pro 
    4700                 4705                 4710             


Met Ser  Phe Asp Ala Ala Gln  Trp Glu Ile Leu Ala  Pro Ala Ile 
    4715                 4720                 4725             


Gly Gly  Gln Val Ile Met Gly  Pro Leu Gly Cys Tyr  Arg Asp Pro 
    4730                 4735                 4740             


Asp Ala  Ile Ile Lys Thr Ile  Leu Gln His Gln Val  Thr Thr Leu 
    4745                 4750                 4755             


Gln Cys  Val Pro Thr Leu Leu  Gln Ala Leu Leu Asp  Asn Pro Asn 
    4760                 4765                 4770             


Phe Leu  Asp Cys Leu Ser Leu  Thr Gln Val Phe Ser  Gly Gly Glu 
    4775                 4780                 4785             


Ala Leu  Thr Thr Lys Leu Ala  Thr Gln Phe Leu Asn  Ser Phe Thr 
    4790                 4795                 4800             


His Cys  Glu Leu Ile Asn Leu  Tyr Gly Pro Thr Glu  Cys Thr Ile 
    4805                 4810                 4815             


Asn Ser  Ser Phe Phe Arg Val  Thr Asn Glu Thr Leu  Pro Asn Tyr 
    4820                 4825                 4830             


Gln Thr  Ser Ile Ser Ile Gly  Ala Pro Val Asp Asn  Thr Glu Tyr 
    4835                 4840                 4845             


Tyr Val  Leu Asp Asp Asp Arg  Leu Pro Val Ala Val  Gly Glu Ile 
    4850                 4855                 4860             


Gly Glu  Leu Tyr Ile Ser Gly  Ala Gln Leu Ala Arg  Gly Tyr Leu 
    4865                 4870                 4875             


His Lys  Pro Glu Met Thr Lys  Asp Lys Phe Ile Cys  Asn His Leu 
    4880                 4885                 4890             


Val Ser  Gly Thr Gln His Gln  Trp Leu Tyr Arg Thr  Gly Asp Leu 
    4895                 4900                 4905             


Val Thr  Arg Gly Ala Asp Gly  Asn Thr Tyr Phe Val  Gly Arg Val 
    4910                 4915                 4920             


Asp Ser  Gln Val Lys Leu Arg  Gly Tyr Arg Ile Glu  Leu Asp Glu 
    4925                 4930                 4935             


Ile Arg  His Ala Ile Glu Glu  His Ser Trp Ile Lys  Thr Ala Ala 
    4940                 4945                 4950             


Met Leu  Ile Lys Lys Asp Ala  Arg Thr Gly Phe Gln  Asn Leu Ile 
    4955                 4960                 4965             


Ala Cys  Val Glu Leu Asp Glu  Lys Glu Ala Ala Leu  Met Asp Gln 
    4970                 4975                 4980             


Gly Asn  Ser Ser Ser His His  Lys Ser Lys Ala Asp  Lys Leu Gln 
    4985                 4990                 4995             


Val Lys  Ala Gln Leu Ser Asn  Ser Gly Cys Arg Ser  Glu Glu Leu 
    5000                 5005                 5010             


Cys Glu  Asn Arg Pro Thr Phe  Leu Leu Pro Tyr Gln  Glu Gly Glu 
    5015                 5020                 5025             


Ile Lys  Gln Arg Glu Tyr Ala  Phe Gly Arg Lys Thr  Tyr Arg Tyr 
    5030                 5035                 5040             


Phe Glu  Gly Thr Glu Ile Thr  Val Glu Lys Leu Lys  Lys Leu Leu 
    5045                 5050                 5055             


Thr Ala  Thr Gln Ser Asn Glu  Ile Ser Ser Leu Pro  Leu Ser His 
    5060                 5065                 5070             


Leu Thr  Leu Asn Asp Phe Gly  Tyr Ala Leu Arg Tyr  Phe Gly Gln 
    5075                 5080                 5085             


Phe Thr  Ser His Gln Arg Leu  Leu Pro Lys Tyr Ala  Tyr Ala Ser 
    5090                 5095                 5100             


Pro Gly  Ala Leu Tyr Ala Thr  Gln Met Tyr Phe Glu  Leu His Asn 
    5105                 5110                 5115             


Val Leu  Gly Leu Asp Ala Gly  Ile Tyr Tyr Tyr His  Pro Val Thr 
    5120                 5125                 5130             


His Lys  Leu Ile Lys Ile Ser  Thr Leu Ser Arg Arg  Gln Met Pro 
    5135                 5140                 5145             


Thr Ile  Lys Val His Phe Ile  Gly Lys His Glu Ala  Ile Glu Pro 
    5150                 5155                 5160             


Val Tyr  Lys Asn Asn Ile Gln  Glu Val Leu Glu Met  Glu Ala Gly 
    5165                 5170                 5175             


His Met  Met Gly Leu Phe Asp  Asp Val Leu Pro Glu  Ile Gly Leu 
    5180                 5185                 5190             


Ser Ile  Gly Lys Ser Glu Tyr  Gln Asp Glu Cys Pro  Asp Trp Tyr 
    5195                 5200                 5205             


Asp Gly  Asp Ile Gln Asp Tyr  Tyr Leu Gly Ala Phe  Glu Ile Cys 
    5210                 5215                 5220             


Ser Tyr  Glu His Gly Leu Pro  Pro Phe Glu Thr Asp  Ile Tyr Leu 
    5225                 5230                 5235             


Gln Thr  His Ala His Lys Ile  Pro Glu Met Pro Cys  Gly Leu Tyr 
    5240                 5245                 5250             


His Phe  Ser Asn Gly Glu Phe  Val Arg Ile Ser Asp  Asp Ile Val 
    5255                 5260                 5265             


Arg Lys  Lys Asp Val Ile Ala  Ile Asn Gln Gln Val  Tyr Asp Arg 
    5270                 5275                 5280             


Ser Ser  Phe Gly Val Ser Ile  Ile Pro Arg Cys Val  Pro Glu Trp 
    5285                 5290                 5295             


His Tyr  Tyr Ile Thr Leu Gly  Arg Arg Leu His Ala  Leu Gln Ser 
    5300                 5305                 5310             


Asn Pro  Leu Tyr Ile Gly Leu  Met Ser Ser Gly Tyr  Ser Ser Lys 
    5315                 5320                 5325             


Ser Asn  Asn Asp Leu Pro Ser  Ala Lys Arg Met Arg  Ser Ile Leu 
    5330                 5335                 5340             


Asn Ala  Leu Asp Arg Pro Met  Ala Ala Phe Tyr Phe  Cys Ile Gly 
    5345                 5350                 5355             


Gly Gly  Ile Ser Gln Ala Gln  Tyr Met Cys Glu Gly  Met Lys Glu 
    5360                 5365                 5370             


Asp Val  Val His Met Lys Gly  Pro Val Glu Ile Ile  Lys Asp Asp 
    5375                 5380                 5385             


Leu Gln  Gln Gln Leu Pro Gln  Tyr Met Ile Pro Asn  Lys Val Leu 
    5390                 5395                 5400             


Val Phe  Asp Lys Leu Pro Leu  Thr Ala Asn Gly Lys  Val Asp Tyr 
    5405                 5410                 5415             


Gln Ser  Leu Ser Glu Ser Lys  Ala Val Glu Asn Val  Ser Thr Gln 
    5420                 5425                 5430             


Arg Leu  Leu Val Pro Leu His  Thr Asp Thr Glu Ile  Arg Leu Gly 
    5435                 5440                 5445             


Lys Ile  Trp Met Glu Val Leu  Lys Trp Asp Ser Val  Ser Ala Leu 
    5450                 5455                 5460             


Asp Asp  Phe Phe Glu Ser Gly  Gly Asn Ser Leu Met  Ala Val Ala 
    5465                 5470                 5475             


Met Val  Asn Lys Ile Asn Ala  Ala Phe Asn Ile Arg  Phe Pro Leu 
    5480                 5485                 5490             


Gln Ile  Leu Phe Gln Ser Pro  Asn Ile Ala Glu Leu  Ala Lys Trp 
    5495                 5500                 5505             


Ile Glu  Gln Thr Asp Ser Lys  Thr Ile Ser Arg Leu  Ile Leu Leu 
    5510                 5515                 5520             


Asn Gln  Ala Ser Lys Asp Pro  Ile Tyr Cys Trp Pro  Gly Leu Gly 
    5525                 5530                 5535             


Gly Tyr  Pro Met Ser Leu Arg  Leu Leu Ala Asn Lys  Val Val Pro 
    5540                 5545                 5550             


Asp Arg  Ala Phe Tyr Gly Ile  Gln Ala Tyr Gly Ile  Asn Glu Ser 
    5555                 5560                 5565             


Glu Ile  Pro Phe Ser Ser Ile  Gln Arg Met Ala Glu  Glu Asp Ile 
    5570                 5575                 5580             


Lys Glu  Ile Lys Lys Ile Gln  Pro Glu Gly Pro Tyr  Ile Leu Trp 
    5585                 5590                 5595             


Gly Tyr  Ser Phe Gly Ala Arg  Val Ala Phe Glu Val  Ala Tyr Gln 
    5600                 5605                 5610             


Leu Glu  Gln Ala Gly Glu Glu  Val Asn Ala Leu Asn  Leu Leu Ala 
    5615                 5620                 5625             


Pro Gly  Ser Pro His Leu Asp  Met Lys Gln Ala Glu  Tyr Met Asp 
    5630                 5635                 5640             


Lys Gly  Ala Glu Phe Thr Asn  Pro Ala Phe Val Lys  Ile Leu Phe 
    5645                 5650                 5655             


Ser Val  Phe Ser Arg Ser Ile  Asn Ser Pro Met Val  Lys Thr Cys 
    5660                 5665                 5670             


Leu Glu  Gln Val Asn Ser Glu  Thr Thr Phe Ile Asn  Phe Ile Cys 
    5675                 5680                 5685             


Ser Arg  Phe Lys Asn Leu Glu  Pro Ser Leu Val Lys  Arg Ile Val 
    5690                 5695                 5700             


Arg Ile  Val Thr Leu Thr Tyr  Asp Phe Lys Tyr Ser  Ile Asp Glu 
    5705                 5710                 5715             


Leu Tyr  His Arg His Leu Lys  Ala Pro Ile Thr Ile  Phe Lys Ala 
    5720                 5725                 5730             


Asn Arg  Asp Asn Asp Ser Phe  Ile Glu Glu Ser Asp  Val Ile Ser 
    5735                 5740                 5745             


Ser Met  Ser Pro Lys Ile Ile  Glu Leu Ile Ser Asp  His Tyr Gln 
    5750                 5755                 5760             


Leu Leu  Glu Ser Glu Gly Val  Ala Glu Ile Glu Lys  Ile Ile 
    5765                 5770                 5775         


<210>  33
<211>  3251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Indigoidine-tagged Dipeptide consisting of
       Proline and Leucine

<400>  33

Met Asp Cys Val Ala Asn Asn Ser Gly Val Glu Leu Cys Gln Ile Pro 
1               5                   10                  15      


Leu Leu Thr Glu Ala Glu Thr Ser Gln Leu Leu Ala Lys Arg Thr Glu 
            20                  25                  30          


Thr Ala Ala Asp Tyr Pro Ala Ala Thr Met His Glu Leu Phe Ser Arg 
        35                  40                  45              


Gln Ala Glu Lys Thr Pro Glu Gln Val Ala Val Val Phe Ala Asp Gln 
    50                  55                  60                  


His Leu Thr Tyr Arg Glu Leu Asp Glu Lys Ser Asn Gln Leu Ala Arg 
65                  70                  75                  80  


Phe Leu Arg Lys Lys Gly Ile Gly Thr Gly Ser Leu Val Gly Thr Leu 
                85                  90                  95      


Leu Asp Arg Ser Leu Asp Met Ile Val Gly Ile Leu Gly Val Leu Lys 
            100                 105                 110         


Ala Gly Gly Ala Phe Val Pro Ile Asp Pro Glu Leu Pro Ala Glu Arg 
        115                 120                 125             


Ile Ala Tyr Met Leu Thr His Ser Arg Val Pro Leu Val Val Thr Gln 
    130                 135                 140                 


Asn His Leu Arg Ala Lys Val Thr Thr Pro Thr Glu Thr Ile Asp Ile 
145                 150                 155                 160 


Asn Thr Ala Val Ile Gly Glu Glu Ser Arg Ala Pro Ile Glu Ser Leu 
                165                 170                 175     


Asn Gln Pro His Asp Leu Phe Tyr Ile Ile Tyr Thr Ser Gly Thr Thr 
            180                 185                 190         


Gly Gln Pro Lys Gly Val Met Leu Glu His Arg Asn Met Ala Asn Leu 
        195                 200                 205             


Met His Phe Thr Phe Asp Gln Thr Asn Ile Ala Phe His Glu Lys Val 
    210                 215                 220                 


Leu Gln Tyr Thr Thr Cys Ser Phe Asp Val Cys Tyr Gln Glu Ile Phe 
225                 230                 235                 240 


Ser Thr Leu Leu Ser Gly Gly Gln Leu Tyr Leu Ile Thr Asn Glu Leu 
                245                 250                 255     


Arg Arg His Val Glu Lys Leu Phe Ala Phe Ile Gln Glu Lys Gln Ile 
            260                 265                 270         


Ser Ile Leu Ser Leu Pro Val Ser Phe Leu Lys Phe Ile Phe Asn Glu 
        275                 280                 285             


Gln Asp Tyr Ala Gln Ser Phe Pro Arg Cys Val Lys His Ile Ile Thr 
    290                 295                 300                 


Ala Gly Glu Gln Leu Val Val Thr His Glu Leu Gln Lys Tyr Leu Arg 
305                 310                 315                 320 


Gln His Arg Val Phe Leu His Asn His Tyr Gly Pro Ser Glu Thr His 
                325                 330                 335     


Val Val Thr Thr Cys Thr Met Asp Pro Gly Gln Ala Ile Pro Glu Leu 
            340                 345                 350         


Pro Pro Ile Gly Lys Pro Ile Ser Asn Thr Gly Ile Tyr Ile Leu Asp 
        355                 360                 365             


Glu Gly Leu Gln Leu Lys Pro Glu Gly Ile Val Gly Glu Leu Tyr Ile 
    370                 375                 380                 


Ser Gly Ala Asn Val Gly Arg Gly Tyr Leu His Gln Pro Glu Leu Thr 
385                 390                 395                 400 


Ala Glu Lys Phe Leu Asp Asn Pro Tyr Gln Pro Gly Glu Arg Met Tyr 
                405                 410                 415     


Arg Thr Gly Asp Leu Ala Leu Trp Leu Pro Asp Gly Gln Leu Glu Phe 
            420                 425                 430         


Leu Gly Arg Ile Asp His Gln Val Lys Ile Arg Gly His Arg Ile Glu 
        435                 440                 445             


Leu Gly Glu Ile Glu Ser Arg Leu Leu Asn His Pro Ala Ile Lys Glu 
    450                 455                 460                 


Ala Val Val Ile Asp Arg Ala Asp Glu Thr Gly Gly Lys Phe Leu Cys 
465                 470                 475                 480 


Ala Tyr Val Val Leu Gln Lys Ala Leu Ser Asp Glu Glu Met Arg Ala 
                485                 490                 495     


Tyr Leu Ala Gln Ala Leu Pro Glu Tyr Met Ile Pro Ser Phe Phe Val 
            500                 505                 510         


Thr Leu Glu Arg Ile Pro Val Thr Pro Asn Gly Lys Thr Asp Arg Arg 
        515                 520                 525             


Ala Leu Pro Lys Pro Glu Gly Ser Ala Lys Thr Lys Ala Asp Tyr Val 
    530                 535                 540                 


Ala Pro Thr Thr Glu Leu Glu Gln Lys Leu Val Ala Ile Trp Glu Gln 
545                 550                 555                 560 


Ile Leu Gly Val Ser Pro Ile Gly Ile Gln Asp His Phe Phe Thr Leu 
                565                 570                 575     


Gly Gly His Ser Leu Lys Ala Ile Gln Leu Ile Ser Arg Ile Gln Lys 
            580                 585                 590         


Glu Cys Gln Ala Asp Val Pro Leu Arg Val Leu Phe Glu Gln Pro Thr 
        595                 600                 605             


Ile Gln Ala Leu Ala Ala Tyr Val Glu Gly Gly Glu Glu Gly Asn Val 
    610                 615                 620                 


Phe Ser Ile Glu Pro Val Gln Lys Gln Ala Tyr Tyr Pro Val Ser Ser 
625                 630                 635                 640 


Ala Gln Lys Arg Met Tyr Ile Leu Asp Gln Phe Glu Gly Val Gly Ile 
                645                 650                 655     


Ser Tyr Asn Met Pro Ser Thr Met Leu Ile Glu Gly Lys Leu Glu Arg 
            660                 665                 670         


Thr Arg Val Glu Ala Ala Phe Gln Arg Leu Ile Ala Arg His Glu Ser 
        675                 680                 685             


Leu Arg Thr Ser Phe Ala Val Val Asn Gly Glu Pro Val Gln Asn Ile 
    690                 695                 700                 


His Glu Asp Val Pro Phe Ala Leu Ala Tyr Ser Glu Val Thr Glu Gln 
705                 710                 715                 720 


Glu Ala Arg Glu Leu Val Ser Ser Leu Val Gln Pro Phe Asp Leu Glu 
                725                 730                 735     


Val Ala Pro Leu Ile Arg Val Ser Leu Leu Lys Ile Gly Glu Asp Arg 
            740                 745                 750         


Tyr Val Leu Phe Thr Asp Met His His Ser Ile Ser Asp Gly Val Ser 
        755                 760                 765             


Ser Gly Ile Leu Leu Ala Glu Trp Val Gln Leu Tyr Gln Gly Asp Val 
    770                 775                 780                 


Leu Pro Glu Leu Arg Ile Gln Tyr Lys Asp Phe Ala Val Trp Gln Gln 
785                 790                 795                 800 


Glu Phe Ser Gln Ser Ala Ala Phe His Lys Gln Glu Ala Tyr Trp Leu 
                805                 810                 815     


Gln Thr Phe Ala Asp Asp Ile Pro Val Leu Asn Leu Pro Thr Asp Phe 
            820                 825                 830         


Thr Arg Pro Ser Thr Gln Ser Phe Ala Gly Asp Gln Cys Thr Ile Gly 
        835                 840                 845             


Ala Gly Lys Ala Leu Thr Glu Gly Leu His Gln Leu Ala Gln Ala Thr 
    850                 855                 860                 


Gly Thr Thr Leu Tyr Met Val Leu Leu Ala Ala Tyr Asn Val Leu Leu 
865                 870                 875                 880 


Ala Lys Tyr Ala Gly Gln Glu Asp Ile Ile Val Gly Thr Pro Ile Thr 
                885                 890                 895     


Gly Arg Ser His Ala Asp Leu Glu Pro Ile Val Gly Met Phe Val Asn 
            900                 905                 910         


Thr Leu Ala Met Arg Asn Lys Pro Gln Arg Glu Lys Thr Phe Ser Glu 
        915                 920                 925             


Phe Leu Gln Glu Val Lys Gln Asn Ala Leu Asp Ala Tyr Gly His Gln 
    930                 935                 940                 


Asp Tyr Pro Phe Glu Glu Leu Val Glu Lys Leu Ala Ile Ala Arg Asp 
945                 950                 955                 960 


Leu Ser Arg Asn Pro Leu Phe Asp Thr Val Phe Thr Phe Gln Asn Ser 
                965                 970                 975     


Thr Glu Glu Val Met Thr Leu Pro Glu Cys Thr Leu Ala Pro Phe Met 
            980                 985                 990         


Thr Asp Glu Thr Gly Gln His Ala  Lys Phe Asp Leu Thr  Phe Ser Ala 
        995                 1000                 1005             


Thr Glu  Glu Arg Glu Glu Met  Thr Ile Gly Val Glu  Tyr Ser Thr 
    1010                 1015                 1020             


Ser Leu  Phe Thr Arg Glu Thr  Met Glu Arg Phe Ser  Arg His Phe 
    1025                 1030                 1035             


Leu Thr  Ile Ala Ala Ser Ile  Val Gln Asn Pro His  Ile Arg Leu 
    1040                 1045                 1050             


Gly Glu  Ile Asp Met Leu Leu  Pro Glu Glu Lys Gln  Gln Ile Leu 
    1055                 1060                 1065             


Ala Gly  Phe Asn Asp Thr Ala  Val Ser Tyr Ala Leu  Asp Lys Thr 
    1070                 1075                 1080             


Leu His  Gln Leu Phe Glu Glu  Gln Val Asp Lys Thr  Pro Asp Gln 
    1085                 1090                 1095             


Ala Ala  Leu Leu Phe Ser Glu  Gln Ser Leu Thr Tyr  Ser Glu Leu 
    1100                 1105                 1110             


Asn Glu  Arg Ala Asn Arg Leu  Ala Arg Val Leu Arg  Ala Lys Gly 
    1115                 1120                 1125             


Val Gly  Pro Asp Arg Leu Val  Ala Ile Met Ala Glu  Arg Ser Pro 
    1130                 1135                 1140             


Glu Met  Val Ile Gly Ile Leu  Gly Ile Leu Lys Ala  Gly Gly Ala 
    1145                 1150                 1155             


Tyr Val  Pro Val Asp Pro Gly  Tyr Pro Gln Glu Arg  Ile Gln Tyr 
    1160                 1165                 1170             


Leu Leu  Glu Asp Ser Asn Ala  Ala Leu Leu Leu Ser  Gln Ala His 
    1175                 1180                 1185             


Leu Leu  Pro Leu Leu Ala Gln  Val Ser Ser Glu Leu  Pro Glu Cys 
    1190                 1195                 1200             


Leu Asp  Leu Asn Ala Glu Leu  Asp Ala Gly Leu Ser  Gly Ser Asn 
    1205                 1210                 1215             


Leu Pro  Ala Val Asn Gln Pro  Thr Asp Leu Ala Tyr  Val Ile Tyr 
    1220                 1225                 1230             


Thr Ser  Gly Thr Thr Gly Lys  Pro Lys Gly Val Met  Ile Pro His 
    1235                 1240                 1245             


Gln Gly  Ile Val Asn Cys Leu  Gln Trp Arg Arg Asp  Glu Tyr Gly 
    1250                 1255                 1260             


Phe Gly  Pro Ser Asp Lys Ala  Leu Gln Val Phe Ser  Phe Ala Phe 
    1265                 1270                 1275             


Asp Gly  Phe Val Ala Ser Leu  Phe Ala Pro Leu Leu  Gly Gly Ala 
    1280                 1285                 1290             


Thr Cys  Val Leu Pro Gln Glu  Ala Ala Ala Lys Asp  Pro Val Ala 
    1295                 1300                 1305             


Leu Lys  Lys Leu Met Ala Ala  Thr Glu Val Thr His  Tyr Tyr Gly 
    1310                 1315                 1320             


Val Pro  Ser Leu Phe Gln Ala  Ile Leu Asp Cys Ser  Thr Thr Thr 
    1325                 1330                 1335             


Asp Phe  Asn Gln Leu Arg Cys  Val Thr Leu Gly Gly  Glu Lys Leu 
    1340                 1345                 1350             


Pro Val  Gln Leu Val Gln Lys  Thr Lys Glu Lys His  Pro Ala Ile 
    1355                 1360                 1365             


Glu Ile  Asn Asn Glu Tyr Gly  Pro Thr Glu Asn Ser  Val Val Thr 
    1370                 1375                 1380             


Thr Ile  Ser Arg Ser Ile Glu  Ala Gly Gln Ala Ile  Thr Ile Gly 
    1385                 1390                 1395             


Arg Pro  Leu Ala Asn Val Gln  Val Tyr Ile Val Asp  Glu Gln His 
    1400                 1405                 1410             


His Leu  Gln Pro Ile Gly Val  Val Gly Glu Leu Cys  Ile Gly Gly 
    1415                 1420                 1425             


Ala Gly  Leu Ala Arg Gly Tyr  Leu Asn Lys Pro Glu  Leu Thr Ala 
    1430                 1435                 1440             


Glu Lys  Phe Val Ala Asn Pro  Phe Arg Pro Gly Glu  Arg Met Tyr 
    1445                 1450                 1455             


Lys Thr  Gly Asp Leu Val Lys  Trp Arg Thr Asp Gly  Thr Ile Glu 
    1460                 1465                 1470             


Tyr Ile  Gly Arg Ala Asp Glu  Gln Val Lys Val Arg  Gly Tyr Arg 
    1475                 1480                 1485             


Ile Glu  Ile Gly Glu Ile Glu  Ser Ala Val Leu Ala  Tyr Gln Gly 
    1490                 1495                 1500             


Ile Asp  Gln Ala Val Val Val  Ala Arg Asp Asp Asp  Ala Thr Ala 
    1505                 1510                 1515             


Gly Ser  Tyr Leu Cys Ala Tyr  Phe Val Ala Ala Thr  Ala Val Ser 
    1520                 1525                 1530             


Val Ser  Gly Leu Arg Ser His  Leu Ala Lys Glu Leu  Pro Ala Tyr 
    1535                 1540                 1545             


Met Ile  Pro Ser Tyr Phe Val  Glu Leu Asp Gln Leu  Pro Leu Ser 
    1550                 1555                 1560             


Ala Asn  Gly Lys Val Asp Arg  Lys Ala Leu Pro Lys  Pro Gln Gln 
    1565                 1570                 1575             


Ser Asp  Ala Thr Thr Arg Glu  Tyr Val Ala Pro Arg  Asn Ala Thr 
    1580                 1585                 1590             


Glu Gln  Gln Leu Ala Ala Ile  Trp Gln Glu Val Leu  Gly Val Glu 
    1595                 1600                 1605             


Pro Ile  Gly Ile Thr Asp Gln  Phe Phe Glu Leu Gly  Gly His Ser 
    1610                 1615                 1620             


Leu Lys  Ala Thr Leu Leu Ile  Ala Lys Val Tyr Glu  Tyr Met Gln 
    1625                 1630                 1635             


Ile Glu  Leu Pro Leu Asn Leu  Ile Phe Gln Tyr Pro  Thr Ile Glu 
    1640                 1645                 1650             


Lys Val  Ala Asp Phe Ile Thr  Ser Glu Lys Thr Glu  Tyr Thr Ala 
    1655                 1660                 1665             


Ile Gln  Pro Val Ala Ala Gln  Glu Phe Tyr Pro Val  Ser Ser Ala 
    1670                 1675                 1680             


Gln Lys  Arg Met Tyr Ile Leu  Gln Gln Phe Glu Gly  Asn Gly Ile 
    1685                 1690                 1695             


Ser Tyr  Asn Ile Ser Gly Ala  Ile Leu Leu Glu Gly  Lys Leu Asp 
    1700                 1705                 1710             


Tyr Ala  Arg Phe Ala Ser Ala  Val Gln Gln Leu Ala  Glu Arg His 
    1715                 1720                 1725             


Glu Ala  Leu Arg Thr Ser Phe  His Arg Ile Asp Gly  Glu Pro Val 
    1730                 1735                 1740             


Gln Lys  Val His Glu Glu Val  Glu Val Pro Leu Phe  Met Leu Glu 
    1745                 1750                 1755             


Ala Pro  Glu Asp Gln Ala Glu  Lys Ile Met Arg Glu  Phe Val Arg 
    1760                 1765                 1770             


Pro Phe  Asp Leu Gly Val Ala  Pro Leu Met Arg Thr  Gly Leu Leu 
    1775                 1780                 1785             


Lys Leu  Gly Lys Asp Arg His  Leu Phe Leu Leu Asp  Met His His 
    1790                 1795                 1800             


Ile Ile  Ser Asp Gly Val Ser  Ser Gln Ile Leu Leu  Arg Glu Phe 
    1805                 1810                 1815             


Ala Glu  Leu Tyr Gln Gly Ala  Asp Leu Gln Pro Leu  Ser Leu Gln 
    1820                 1825                 1830             


Tyr Lys  Asp Phe Ala Ala Trp  Gln Asn Glu Leu Phe  Gln Thr Glu 
    1835                 1840                 1845             


Ala Tyr  Lys Lys Gln Glu Gln  His Trp Leu Asn Thr  Phe Ala Asp 
    1850                 1855                 1860             


Glu Ile  Pro Leu Leu Asn Leu  Pro Thr Asp Tyr Pro  Arg Pro Ser 
    1865                 1870                 1875             


Val Gln  Ser Phe Ala Gly Asp  Leu Val Leu Phe Ala  Ala Gly Lys 
    1880                 1885                 1890             


Glu Leu  Leu Glu Arg Leu Gln  Gln Val Ala Ser Glu  Thr Gly Thr 
    1895                 1900                 1905             


Thr Leu  Tyr Met Ile Leu Leu  Ala Ala Tyr Asn Val  Leu Leu Ser 
    1910                 1915                 1920             


Lys Tyr  Thr Gly Gln Glu Asp  Ile Ile Val Gly Thr  Pro Val Ala 
    1925                 1930                 1935             


Gly Arg  Ser His Ala Asp Val  Glu Asn Ile Met Gly  Ile Phe Val 
    1940                 1945                 1950             


Asn Thr  Leu Ala Leu Arg Asn  Gln Pro Ala Ser Ser  Lys Thr Met 
    1955                 1960                 1965             


Leu Glu  Asn Asn Ile Thr Gln  Cys Asp Ser Ile Asn  Asp Val Tyr 
    1970                 1975                 1980             


Leu Lys  Glu Glu Ala Ile Thr  Leu Met Asp Met Leu  Glu Ser Gln 
    1985                 1990                 1995             


Leu Lys  His Gln Ala Asp Gly  Tyr Val Val Ile Asp  Gln Glu Glu 
    2000                 2005                 2010             


Ser Leu  Ser Tyr Ala Asp Phe  Tyr Leu Arg Val Lys  Glu Ile Gly 
    2015                 2020                 2025             


Tyr Cys  Leu Ser Glu Ile Ser  Ser Lys Asn Ser Val  Gly Ile Gly 
    2030                 2035                 2040             


Leu Phe  Cys Asp Pro Ser Ile  Asp Leu Ile Cys Gly  Ala Trp Gly 
    2045                 2050                 2055             


Ile Leu  Ser Ala Asp Lys Ala  Tyr Leu Pro Leu Ser  Pro Asp Tyr 
    2060                 2065                 2070             


Pro Thr  Glu Arg Leu Lys Tyr  Met Ile Glu Asp Ser  Gly Ile Asp 
    2075                 2080                 2085             


Val Ile  Phe Thr Gln Ser His  Leu Lys Ala Gln Leu  Gln Asp Ile 
    2090                 2095                 2100             


Ala Pro  Lys Ser Val Leu Ile  Met Thr Pro Glu Asp  Val Ala Leu 
    2105                 2110                 2115             


Thr Ile  Lys Thr Arg Thr Ile  Glu Asp Ile Leu Gly  Thr Val Gln 
    2120                 2125                 2130             


Val Pro  Lys Pro Thr Ser Leu  Ala Tyr Ile Ile Tyr  Thr Ser Gly 
    2135                 2140                 2145             


Ser Thr  Gly Lys Pro Lys Gly  Val Met Ile Glu His  His Ser Ile 
    2150                 2155                 2160             


Val Asn  Gln Met Arg Phe Leu  Ala Lys Ala Phe Lys  Leu Gly Cys 
    2165                 2170                 2175             


His Ser  Arg Ile Leu Gln Lys  Thr Pro Met Ser Phe  Asp Ala Ala 
    2180                 2185                 2190             


Gln Trp  Glu Ile Leu Ala Pro  Ala Ile Gly Gly Gln  Val Ile Met 
    2195                 2200                 2205             


Gly Pro  Leu Gly Cys Tyr Arg  Asp Pro Asp Ala Ile  Ile Lys Thr 
    2210                 2215                 2220             


Ile Leu  Gln His Gln Val Thr  Thr Leu Gln Cys Val  Pro Thr Leu 
    2225                 2230                 2235             


Leu Gln  Ala Leu Leu Asp Asn  Pro Asn Phe Leu Asp  Cys Leu Ser 
    2240                 2245                 2250             


Leu Thr  Gln Val Phe Ser Gly  Gly Glu Ala Leu Thr  Thr Lys Leu 
    2255                 2260                 2265             


Ala Thr  Gln Phe Leu Asn Ser  Phe Thr His Cys Glu  Leu Ile Asn 
    2270                 2275                 2280             


Leu Tyr  Gly Pro Thr Glu Cys  Thr Ile Asn Ser Ser  Phe Phe Arg 
    2285                 2290                 2295             


Val Thr  Asn Glu Thr Leu Pro  Asn Tyr Gln Thr Ser  Ile Ser Ile 
    2300                 2305                 2310             


Gly Ala  Pro Val Asp Asn Thr  Glu Tyr Tyr Val Leu  Asp Asp Asp 
    2315                 2320                 2325             


Arg Leu  Pro Val Ala Val Gly  Glu Ile Gly Glu Leu  Tyr Ile Ser 
    2330                 2335                 2340             


Gly Ala  Gln Leu Ala Arg Gly  Tyr Leu His Lys Pro  Glu Met Thr 
    2345                 2350                 2355             


Lys Asp  Lys Phe Ile Cys Asn  His Leu Val Ser Gly  Thr Gln His 
    2360                 2365                 2370             


Gln Trp  Leu Tyr Arg Thr Gly  Asp Leu Val Thr Arg  Gly Ala Asp 
    2375                 2380                 2385             


Gly Asn  Thr Tyr Phe Val Gly  Arg Val Asp Ser Gln  Val Lys Leu 
    2390                 2395                 2400             


Arg Gly  Tyr Arg Ile Glu Leu  Asp Glu Ile Arg His  Ala Ile Glu 
    2405                 2410                 2415             


Glu His  Ser Trp Ile Lys Thr  Ala Ala Met Leu Ile  Lys Lys Asp 
    2420                 2425                 2430             


Ala Arg  Thr Gly Phe Gln Asn  Leu Ile Ala Cys Val  Glu Leu Asp 
    2435                 2440                 2445             


Glu Lys  Glu Ala Ala Leu Met  Asp Gln Gly Asn Ser  Ser Ser His 
    2450                 2455                 2460             


His Lys  Ser Lys Ala Asp Lys  Leu Gln Val Lys Ala  Gln Leu Ser 
    2465                 2470                 2475             


Asn Ser  Gly Cys Arg Ser Glu  Glu Leu Cys Glu Asn  Arg Pro Thr 
    2480                 2485                 2490             


Phe Leu  Leu Pro Tyr Gln Glu  Gly Glu Ile Lys Gln  Arg Glu Tyr 
    2495                 2500                 2505             


Ala Phe  Gly Arg Lys Thr Tyr  Arg Tyr Phe Glu Gly  Thr Glu Ile 
    2510                 2515                 2520             


Thr Val  Glu Lys Leu Lys Lys  Leu Leu Thr Ala Thr  Gln Ser Asn 
    2525                 2530                 2535             


Glu Ile  Ser Ser Leu Pro Leu  Ser His Leu Thr Leu  Asn Asp Phe 
    2540                 2545                 2550             


Gly Tyr  Ala Leu Arg Tyr Phe  Gly Gln Phe Thr Ser  His Gln Arg 
    2555                 2560                 2565             


Leu Leu  Pro Lys Tyr Ala Tyr  Ala Ser Pro Gly Ala  Leu Tyr Ala 
    2570                 2575                 2580             


Thr Gln  Met Tyr Phe Glu Leu  His Asn Val Leu Gly  Leu Asp Ala 
    2585                 2590                 2595             


Gly Ile  Tyr Tyr Tyr His Pro  Val Thr His Lys Leu  Ile Lys Ile 
    2600                 2605                 2610             


Ser Thr  Leu Ser Arg Arg Gln  Met Pro Thr Ile Lys  Val His Phe 
    2615                 2620                 2625             


Ile Gly  Lys His Glu Ala Ile  Glu Pro Val Tyr Lys  Asn Asn Ile 
    2630                 2635                 2640             


Gln Glu  Val Leu Glu Met Glu  Ala Gly His Met Met  Gly Leu Phe 
    2645                 2650                 2655             


Asp Asp  Val Leu Pro Glu Ile  Gly Leu Ser Ile Gly  Lys Ser Glu 
    2660                 2665                 2670             


Tyr Gln  Asp Glu Cys Pro Asp  Trp Tyr Asp Gly Asp  Ile Gln Asp 
    2675                 2680                 2685             


Tyr Tyr  Leu Gly Ala Phe Glu  Ile Cys Ser Tyr Glu  His Gly Leu 
    2690                 2695                 2700             


Pro Pro  Phe Glu Thr Asp Ile  Tyr Leu Gln Thr His  Ala His Lys 
    2705                 2710                 2715             


Ile Pro  Glu Met Pro Cys Gly  Leu Tyr His Phe Ser  Asn Gly Glu 
    2720                 2725                 2730             


Phe Val  Arg Ile Ser Asp Asp  Ile Val Arg Lys Lys  Asp Val Ile 
    2735                 2740                 2745             


Ala Ile  Asn Gln Gln Val Tyr  Asp Arg Ser Ser Phe  Gly Val Ser 
    2750                 2755                 2760             


Ile Ile  Pro Arg Cys Val Pro  Glu Trp His Tyr Tyr  Ile Thr Leu 
    2765                 2770                 2775             


Gly Arg  Arg Leu His Ala Leu  Gln Ser Asn Pro Leu  Tyr Ile Gly 
    2780                 2785                 2790             


Leu Met  Ser Ser Gly Tyr Ser  Ser Lys Ser Asn Asn  Asp Leu Pro 
    2795                 2800                 2805             


Ser Ala  Lys Arg Met Arg Ser  Ile Leu Asn Ala Leu  Asp Arg Pro 
    2810                 2815                 2820             


Met Ala  Ala Phe Tyr Phe Cys  Ile Gly Gly Gly Ile  Ser Gln Ala 
    2825                 2830                 2835             


Gln Tyr  Met Cys Glu Gly Met  Lys Glu Asp Val Val  His Met Lys 
    2840                 2845                 2850             


Gly Pro  Val Glu Ile Ile Lys  Asp Asp Leu Gln Gln  Gln Leu Pro 
    2855                 2860                 2865             


Gln Tyr  Met Ile Pro Asn Lys  Val Leu Val Phe Asp  Lys Leu Pro 
    2870                 2875                 2880             


Leu Thr  Ala Asn Gly Lys Val  Asp Tyr Gln Ser Leu  Ser Glu Ser 
    2885                 2890                 2895             


Lys Ala  Val Glu Asn Val Ser  Thr Gln Arg Leu Leu  Val Pro Leu 
    2900                 2905                 2910             


His Thr  Asp Thr Glu Ile Arg  Leu Gly Lys Ile Trp  Met Glu Val 
    2915                 2920                 2925             


Leu Lys  Trp Asp Ser Val Ser  Ala Leu Asp Asp Phe  Phe Glu Ser 
    2930                 2935                 2940             


Gly Gly  Asn Ser Leu Met Ala  Val Ala Met Val Asn  Lys Ile Asn 
    2945                 2950                 2955             


Ala Ala  Phe Asn Ile Arg Phe  Pro Leu Gln Ile Leu  Phe Gln Ser 
    2960                 2965                 2970             


Pro Asn  Ile Ala Glu Leu Ala  Lys Trp Ile Glu Gln  Thr Asp Ser 
    2975                 2980                 2985             


Lys Thr  Ile Ser Arg Leu Ile  Leu Leu Asn Gln Ala  Ser Lys Asp 
    2990                 2995                 3000             


Pro Ile  Tyr Cys Trp Pro Gly  Leu Gly Gly Tyr Pro  Met Ser Leu 
    3005                 3010                 3015             


Arg Leu  Leu Ala Asn Lys Val  Val Pro Asp Arg Ala  Phe Tyr Gly 
    3020                 3025                 3030             


Ile Gln  Ala Tyr Gly Ile Asn  Glu Ser Glu Ile Pro  Phe Ser Ser 
    3035                 3040                 3045             


Ile Gln  Arg Met Ala Glu Glu  Asp Ile Lys Glu Ile  Lys Lys Ile 
    3050                 3055                 3060             


Gln Pro  Glu Gly Pro Tyr Ile  Leu Trp Gly Tyr Ser  Phe Gly Ala 
    3065                 3070                 3075             


Arg Val  Ala Phe Glu Val Ala  Tyr Gln Leu Glu Gln  Ala Gly Glu 
    3080                 3085                 3090             


Glu Val  Asn Ala Leu Asn Leu  Leu Ala Pro Gly Ser  Pro His Leu 
    3095                 3100                 3105             


Asp Met  Lys Gln Ala Glu Tyr  Met Asp Lys Gly Ala  Glu Phe Thr 
    3110                 3115                 3120             


Asn Pro  Ala Phe Val Lys Ile  Leu Phe Ser Val Phe  Ser Arg Ser 
    3125                 3130                 3135             


Ile Asn  Ser Pro Met Val Lys  Thr Cys Leu Glu Gln  Val Asn Ser 
    3140                 3145                 3150             


Glu Thr  Thr Phe Ile Asn Phe  Ile Cys Ser Arg Phe  Lys Asn Leu 
    3155                 3160                 3165             


Glu Pro  Ser Leu Val Lys Arg  Ile Val Arg Ile Val  Thr Leu Thr 
    3170                 3175                 3180             


Tyr Asp  Phe Lys Tyr Ser Ile  Asp Glu Leu Tyr His  Arg His Leu 
    3185                 3190                 3195             


Lys Ala  Pro Ile Thr Ile Phe  Lys Ala Asn Arg Asp  Asn Asp Ser 
    3200                 3205                 3210             


Phe Ile  Glu Glu Ser Asp Val  Ile Ser Ser Met Ser  Pro Lys Ile 
    3215                 3220                 3225             


Ile Glu  Leu Ile Ser Asp His  Tyr Gln Leu Leu Glu  Ser Glu Gly 
    3230                 3235                 3240             


Val Ala  Glu Ile Glu Lys Ile  Ile 
    3245                 3250     


<210>  34
<211>  4284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPS synthesizing a Valine-Indigoidine-tagged Dipeptide 
       consisting of Proline and Leucine. Valine is here used as spacer.

<400>  34

Met Asp Cys Val Ala Asn Asn Ser Gly Val Glu Leu Cys Gln Ile Pro 
1               5                   10                  15      


Leu Leu Thr Glu Ala Glu Thr Ser Gln Leu Leu Ala Lys Arg Thr Glu 
            20                  25                  30          


Thr Ala Ala Asp Tyr Pro Ala Ala Thr Met His Glu Leu Phe Ser Arg 
        35                  40                  45              


Gln Ala Glu Lys Thr Pro Glu Gln Val Ala Val Val Phe Ala Asp Gln 
    50                  55                  60                  


His Leu Thr Tyr Arg Glu Leu Asp Glu Lys Ser Asn Gln Leu Ala Arg 
65                  70                  75                  80  


Phe Leu Arg Lys Lys Gly Ile Gly Thr Gly Ser Leu Val Gly Thr Leu 
                85                  90                  95      


Leu Asp Arg Ser Leu Asp Met Ile Val Gly Ile Leu Gly Val Leu Lys 
            100                 105                 110         


Ala Gly Gly Ala Phe Val Pro Ile Asp Pro Glu Leu Pro Ala Glu Arg 
        115                 120                 125             


Ile Ala Tyr Met Leu Thr His Ser Arg Val Pro Leu Val Val Thr Gln 
    130                 135                 140                 


Asn His Leu Arg Ala Lys Val Thr Thr Pro Thr Glu Thr Ile Asp Ile 
145                 150                 155                 160 


Asn Thr Ala Val Ile Gly Glu Glu Ser Arg Ala Pro Ile Glu Ser Leu 
                165                 170                 175     


Asn Gln Pro His Asp Leu Phe Tyr Ile Ile Tyr Thr Ser Gly Thr Thr 
            180                 185                 190         


Gly Gln Pro Lys Gly Val Met Leu Glu His Arg Asn Met Ala Asn Leu 
        195                 200                 205             


Met His Phe Thr Phe Asp Gln Thr Asn Ile Ala Phe His Glu Lys Val 
    210                 215                 220                 


Leu Gln Tyr Thr Thr Cys Ser Phe Asp Val Cys Tyr Gln Glu Ile Phe 
225                 230                 235                 240 


Ser Thr Leu Leu Ser Gly Gly Gln Leu Tyr Leu Ile Thr Asn Glu Leu 
                245                 250                 255     


Arg Arg His Val Glu Lys Leu Phe Ala Phe Ile Gln Glu Lys Gln Ile 
            260                 265                 270         


Ser Ile Leu Ser Leu Pro Val Ser Phe Leu Lys Phe Ile Phe Asn Glu 
        275                 280                 285             


Gln Asp Tyr Ala Gln Ser Phe Pro Arg Cys Val Lys His Ile Ile Thr 
    290                 295                 300                 


Ala Gly Glu Gln Leu Val Val Thr His Glu Leu Gln Lys Tyr Leu Arg 
305                 310                 315                 320 


Gln His Arg Val Phe Leu His Asn His Tyr Gly Pro Ser Glu Thr His 
                325                 330                 335     


Val Val Thr Thr Cys Thr Met Asp Pro Gly Gln Ala Ile Pro Glu Leu 
            340                 345                 350         


Pro Pro Ile Gly Lys Pro Ile Ser Asn Thr Gly Ile Tyr Ile Leu Asp 
        355                 360                 365             


Glu Gly Leu Gln Leu Lys Pro Glu Gly Ile Val Gly Glu Leu Tyr Ile 
    370                 375                 380                 


Ser Gly Ala Asn Val Gly Arg Gly Tyr Leu His Gln Pro Glu Leu Thr 
385                 390                 395                 400 


Ala Glu Lys Phe Leu Asp Asn Pro Tyr Gln Pro Gly Glu Arg Met Tyr 
                405                 410                 415     


Arg Thr Gly Asp Leu Ala Leu Trp Leu Pro Asp Gly Gln Leu Glu Phe 
            420                 425                 430         


Leu Gly Arg Ile Asp His Gln Val Lys Ile Arg Gly His Arg Ile Glu 
        435                 440                 445             


Leu Gly Glu Ile Glu Ser Arg Leu Leu Asn His Pro Ala Ile Lys Glu 
    450                 455                 460                 


Ala Val Val Ile Asp Arg Ala Asp Glu Thr Gly Gly Lys Phe Leu Cys 
465                 470                 475                 480 


Ala Tyr Val Val Leu Gln Lys Ala Leu Ser Asp Glu Glu Met Arg Ala 
                485                 490                 495     


Tyr Leu Ala Gln Ala Leu Pro Glu Tyr Met Ile Pro Ser Phe Phe Val 
            500                 505                 510         


Thr Leu Glu Arg Ile Pro Val Thr Pro Asn Gly Lys Thr Asp Arg Arg 
        515                 520                 525             


Ala Leu Pro Lys Pro Glu Gly Ser Ala Lys Thr Lys Ala Asp Tyr Val 
    530                 535                 540                 


Ala Pro Thr Thr Glu Leu Glu Gln Lys Leu Val Ala Ile Trp Glu Gln 
545                 550                 555                 560 


Ile Leu Gly Val Ser Pro Ile Gly Ile Gln Asp His Phe Phe Thr Leu 
                565                 570                 575     


Gly Gly His Ser Leu Lys Ala Ile Gln Leu Ile Ser Arg Ile Gln Lys 
            580                 585                 590         


Glu Cys Gln Ala Asp Val Pro Leu Arg Val Leu Phe Glu Gln Pro Thr 
        595                 600                 605             


Ile Gln Ala Leu Ala Ala Tyr Val Glu Gly Gly Glu Glu Gly Asn Val 
    610                 615                 620                 


Phe Ser Ile Glu Pro Val Gln Lys Gln Ala Tyr Tyr Pro Val Ser Ser 
625                 630                 635                 640 


Ala Gln Lys Arg Met Tyr Ile Leu Asp Gln Phe Glu Gly Val Gly Ile 
                645                 650                 655     


Ser Tyr Asn Met Pro Ser Thr Met Leu Ile Glu Gly Lys Leu Glu Arg 
            660                 665                 670         


Thr Arg Val Glu Ala Ala Phe Gln Arg Leu Ile Ala Arg His Glu Ser 
        675                 680                 685             


Leu Arg Thr Ser Phe Ala Val Val Asn Gly Glu Pro Val Gln Asn Ile 
    690                 695                 700                 


His Glu Asp Val Pro Phe Ala Leu Ala Tyr Ser Glu Val Thr Glu Gln 
705                 710                 715                 720 


Glu Ala Arg Glu Leu Val Ser Ser Leu Val Gln Pro Phe Asp Leu Glu 
                725                 730                 735     


Val Ala Pro Leu Ile Arg Val Ser Leu Leu Lys Ile Gly Glu Asp Arg 
            740                 745                 750         


Tyr Val Leu Phe Thr Asp Met His His Ser Ile Ser Asp Gly Val Ser 
        755                 760                 765             


Ser Gly Ile Leu Leu Ala Glu Trp Val Gln Leu Tyr Gln Gly Asp Val 
    770                 775                 780                 


Leu Pro Glu Leu Arg Ile Gln Tyr Lys Asp Phe Ala Val Trp Gln Gln 
785                 790                 795                 800 


Glu Phe Ser Gln Ser Ala Ala Phe His Lys Gln Glu Ala Tyr Trp Leu 
                805                 810                 815     


Gln Thr Phe Ala Asp Asp Ile Pro Val Leu Asn Leu Pro Thr Asp Phe 
            820                 825                 830         


Thr Arg Pro Ser Thr Gln Ser Phe Ala Gly Asp Gln Cys Thr Ile Gly 
        835                 840                 845             


Ala Gly Lys Ala Leu Thr Glu Gly Leu His Gln Leu Ala Gln Ala Thr 
    850                 855                 860                 


Gly Thr Thr Leu Tyr Met Val Leu Leu Ala Ala Tyr Asn Val Leu Leu 
865                 870                 875                 880 


Ala Lys Tyr Ala Gly Gln Glu Asp Ile Ile Val Gly Thr Pro Ile Thr 
                885                 890                 895     


Gly Arg Ser His Ala Asp Leu Glu Pro Ile Val Gly Met Phe Val Asn 
            900                 905                 910         


Thr Leu Ala Met Arg Asn Lys Pro Gln Arg Glu Lys Thr Phe Ser Glu 
        915                 920                 925             


Phe Leu Gln Glu Val Lys Gln Asn Ala Leu Asp Ala Tyr Gly His Gln 
    930                 935                 940                 


Asp Tyr Pro Phe Glu Glu Leu Val Glu Lys Leu Ala Ile Ala Arg Asp 
945                 950                 955                 960 


Leu Ser Arg Asn Pro Leu Phe Asp Thr Val Phe Thr Phe Gln Asn Ser 
                965                 970                 975     


Thr Glu Glu Val Met Thr Leu Pro Glu Cys Thr Leu Ala Pro Phe Met 
            980                 985                 990         


Thr Asp Glu Thr Gly Gln His Ala  Lys Phe Asp Leu Thr  Phe Ser Ala 
        995                 1000                 1005             


Thr Glu  Glu Arg Glu Glu Met  Thr Ile Gly Val Glu  Tyr Ser Thr 
    1010                 1015                 1020             


Ser Leu  Phe Thr Arg Glu Thr  Met Glu Arg Phe Ser  Arg His Phe 
    1025                 1030                 1035             


Leu Thr  Ile Ala Ala Ser Ile  Val Gln Asn Pro His  Ile Arg Leu 
    1040                 1045                 1050             


Gly Glu  Ile Asp Met Leu Leu  Pro Glu Glu Lys Gln  Gln Ile Leu 
    1055                 1060                 1065             


Ala Gly  Phe Asn Asp Thr Ala  Val Ser Tyr Ala Leu  Asp Lys Thr 
    1070                 1075                 1080             


Leu His  Gln Leu Phe Glu Glu  Gln Val Asp Lys Thr  Pro Asp Gln 
    1085                 1090                 1095             


Ala Ala  Leu Leu Phe Ser Glu  Gln Ser Leu Thr Tyr  Ser Glu Leu 
    1100                 1105                 1110             


Asn Glu  Arg Ala Asn Arg Leu  Ala Arg Val Leu Arg  Ala Lys Gly 
    1115                 1120                 1125             


Val Gly  Pro Asp Arg Leu Val  Ala Ile Met Ala Glu  Arg Ser Pro 
    1130                 1135                 1140             


Glu Met  Val Ile Gly Ile Leu  Gly Ile Leu Lys Ala  Gly Gly Ala 
    1145                 1150                 1155             


Tyr Val  Pro Val Asp Pro Gly  Tyr Pro Gln Glu Arg  Ile Gln Tyr 
    1160                 1165                 1170             


Leu Leu  Glu Asp Ser Asn Ala  Ala Leu Leu Leu Ser  Gln Ala His 
    1175                 1180                 1185             


Leu Leu  Pro Leu Leu Ala Gln  Val Ser Ser Glu Leu  Pro Glu Cys 
    1190                 1195                 1200             


Leu Asp  Leu Asn Ala Glu Leu  Asp Ala Gly Leu Ser  Gly Ser Asn 
    1205                 1210                 1215             


Leu Pro  Ala Val Asn Gln Pro  Thr Asp Leu Ala Tyr  Val Ile Tyr 
    1220                 1225                 1230             


Thr Ser  Gly Thr Thr Gly Lys  Pro Lys Gly Val Met  Ile Pro His 
    1235                 1240                 1245             


Gln Gly  Ile Val Asn Cys Leu  Gln Trp Arg Arg Asp  Glu Tyr Gly 
    1250                 1255                 1260             


Phe Gly  Pro Ser Asp Lys Ala  Leu Gln Val Phe Ser  Phe Ala Phe 
    1265                 1270                 1275             


Asp Gly  Phe Val Ala Ser Leu  Phe Ala Pro Leu Leu  Gly Gly Ala 
    1280                 1285                 1290             


Thr Cys  Val Leu Pro Gln Glu  Ala Ala Ala Lys Asp  Pro Val Ala 
    1295                 1300                 1305             


Leu Lys  Lys Leu Met Ala Ala  Thr Glu Val Thr His  Tyr Tyr Gly 
    1310                 1315                 1320             


Val Pro  Ser Leu Phe Gln Ala  Ile Leu Asp Cys Ser  Thr Thr Thr 
    1325                 1330                 1335             


Asp Phe  Asn Gln Leu Arg Cys  Val Thr Leu Gly Gly  Glu Lys Leu 
    1340                 1345                 1350             


Pro Val  Gln Leu Val Gln Lys  Thr Lys Glu Lys His  Pro Ala Ile 
    1355                 1360                 1365             


Glu Ile  Asn Asn Glu Tyr Gly  Pro Thr Glu Asn Ser  Val Val Thr 
    1370                 1375                 1380             


Thr Ile  Ser Arg Ser Ile Glu  Ala Gly Gln Ala Ile  Thr Ile Gly 
    1385                 1390                 1395             


Arg Pro  Leu Ala Asn Val Gln  Val Tyr Ile Val Asp  Glu Gln His 
    1400                 1405                 1410             


His Leu  Gln Pro Ile Gly Val  Val Gly Glu Leu Cys  Ile Gly Gly 
    1415                 1420                 1425             


Ala Gly  Leu Ala Arg Gly Tyr  Leu Asn Lys Pro Glu  Leu Thr Ala 
    1430                 1435                 1440             


Glu Lys  Phe Val Ala Asn Pro  Phe Arg Pro Gly Glu  Arg Met Tyr 
    1445                 1450                 1455             


Lys Thr  Gly Asp Leu Val Lys  Trp Arg Thr Asp Gly  Thr Ile Glu 
    1460                 1465                 1470             


Tyr Ile  Gly Arg Ala Asp Glu  Gln Val Lys Val Arg  Gly Tyr Arg 
    1475                 1480                 1485             


Ile Glu  Ile Gly Glu Ile Glu  Ser Ala Val Leu Ala  Tyr Gln Gly 
    1490                 1495                 1500             


Ile Asp  Gln Ala Val Val Val  Ala Arg Asp Asp Asp  Ala Thr Ala 
    1505                 1510                 1515             


Gly Ser  Tyr Leu Cys Ala Tyr  Phe Val Ala Ala Thr  Ala Val Ser 
    1520                 1525                 1530             


Val Ser  Gly Leu Arg Ser His  Leu Ala Lys Glu Leu  Pro Ala Tyr 
    1535                 1540                 1545             


Met Ile  Pro Ser Tyr Phe Val  Glu Leu Asp Gln Leu  Pro Leu Ser 
    1550                 1555                 1560             


Ala Asn  Gly Lys Val Asp Arg  Lys Ala Leu Pro Lys  Pro Gln Gln 
    1565                 1570                 1575             


Ser Asp  Ala Thr Thr Arg Glu  Tyr Val Ala Pro Arg  Asn Ala Thr 
    1580                 1585                 1590             


Glu Gln  Gln Leu Ala Ala Ile  Trp Gln Glu Val Leu  Gly Val Glu 
    1595                 1600                 1605             


Pro Ile  Gly Ile Thr Asp Gln  Phe Phe Glu Leu Gly  Gly His Ser 
    1610                 1615                 1620             


Leu Lys  Ala Thr Leu Leu Ile  Ala Lys Val Tyr Glu  Tyr Met Gln 
    1625                 1630                 1635             


Ile Glu  Leu Pro Leu Asn Leu  Ile Phe Gln Tyr Pro  Thr Ile Glu 
    1640                 1645                 1650             


Lys Val  Ala Asp Phe Ile Thr  Thr Ser Gly Lys Glu  Thr Tyr Val 
    1655                 1660                 1665             


Pro Ile  Glu Pro Ala Pro Leu  Gln Glu Tyr Tyr Pro  Val Ser Ser 
    1670                 1675                 1680             


Ala Gln  Lys Arg Met Tyr Val  Leu Arg Gln Phe Ala  Asp Thr Gly 
    1685                 1690                 1695             


Thr Val  Tyr Asn Met Pro Ser  Ala Leu Tyr Ile Glu  Gly Asp Leu 
    1700                 1705                 1710             


Asp Arg  Lys Arg Phe Glu Ala  Ala Ile His Gly Leu  Val Glu Arg 
    1715                 1720                 1725             


His Glu  Ser Leu Arg Thr Ser  Phe His Thr Val Asn  Gly Glu Pro 
    1730                 1735                 1740             


Val Gln  Arg Val His Glu His  Val Glu Leu Asn Val  Gln Tyr Ala 
    1745                 1750                 1755             


Glu Val  Thr Glu Ala Gln Val  Glu Pro Thr Val Glu  Ser Phe Val 
    1760                 1765                 1770             


Gln Ala  Phe Asp Leu Thr Lys  Ala Pro Leu Leu Arg  Val Gly Leu 
    1775                 1780                 1785             


Phe Lys  Leu Ala Ala Lys Arg  His Leu Phe Leu Leu  Asp Met His 
    1790                 1795                 1800             


His Ile  Ile Ser Asp Gly Val  Ser Ala Gly Ile Ile  Met Glu Glu 
    1805                 1810                 1815             


Phe Ser  Lys Leu Tyr Arg Gly  Glu Glu Leu Pro Ala  Leu Ser Val 
    1820                 1825                 1830             


His Tyr  Lys Asp Phe Ala Val  Trp Gln Ser Glu Leu  Phe Gln Ser 
    1835                 1840                 1845             


Asp Val  Tyr Thr Glu His Glu  Asn Tyr Trp Leu Asn  Ala Phe Ser 
    1850                 1855                 1860             


Gly Asp  Ile Pro Val Leu Asn  Leu Pro Ala Asp Phe  Ser Arg Pro 
    1865                 1870                 1875             


Leu Thr  Gln Ser Phe Glu Gly  Asp Cys Val Ser Phe  Gln Ala Asp 
    1880                 1885                 1890             


Lys Ala  Leu Leu Asp Asp Leu  His Lys Leu Ala Gln  Glu Ser Gln 
    1895                 1900                 1905             


Ser Thr  Leu Phe Met Val Leu  Leu Ala Ala Tyr Asn  Val Leu Leu 
    1910                 1915                 1920             


Ala Lys  Tyr Ser Gly Gln Glu  Asp Ile Val Val Gly  Thr Pro Ile 
    1925                 1930                 1935             


Ala Gly  Arg Ser His Ala Asp  Ile Glu Asn Val Leu  Gly Met Phe 
    1940                 1945                 1950             


Val Asn  Thr Leu Ala Leu Arg  Asn Tyr Pro Val Glu  Thr Lys His 
    1955                 1960                 1965             


Phe Gln  Ala Phe Leu Glu Glu  Val Lys Gln Asn Thr  Leu Gln Ala 
    1970                 1975                 1980             


Tyr Ala  His Gln Asp Tyr Pro  Phe Glu Ala Leu Val  Glu Lys Leu 
    1985                 1990                 1995             


Asp Ile  Gln Arg Asp Leu Ser  Arg Asn Pro Leu Phe  Asp Thr Met 
    2000                 2005                 2010             


Phe Ile  Leu Gln Asn Leu Asp  Gln Lys Ala Tyr Glu  Leu Asp Gly 
    2015                 2020                 2025             


Leu Lys  Leu Glu Ala Tyr Pro  Ala Gln Ala Gly Asn  Ala Lys Phe 
    2030                 2035                 2040             


Asp Leu  Thr Leu Glu Ala His  Glu Asp Glu Thr Gly  Ile His Phe 
    2045                 2050                 2055             


Ala Leu  Val Tyr Ser Thr Lys  Leu Phe Gln Arg Glu  Ser Ile Glu 
    2060                 2065                 2070             


Arg Met  Ala Gly His Phe Leu  Gln Val Leu Arg Gln  Val Val Ala 
    2075                 2080                 2085             


Asp Gln  Ala Thr Ala Leu Arg  Glu Ile Ser Leu Leu  Ser Glu Glu 
    2090                 2095                 2100             


Glu Arg  Arg Ile Val Thr Val  Asp Phe Asn Asn Thr  Phe Ala Tyr 
    2105                 2110                 2115             


Pro Arg  Asp Leu Thr Ile Gln  Glu Leu Phe Glu Gln  Gln Ala Ala 
    2120                 2125                 2130             


Lys Thr  Pro Glu His Ala Ala  Val Val Met Asp Gly  Gln Met Leu 
    2135                 2140                 2145             


Thr Tyr  Arg Glu Leu Asn Glu  Lys Ala Asn Gln Leu  Ala His Val 
    2150                 2155                 2160             


Leu Arg  Gln Asn Gly Val Gly  Lys Glu Ser Ile Val  Gly Leu Leu 
    2165                 2170                 2175             


Ala Asp  Arg Ser Leu Glu Met  Ile Thr Gly Ile Met  Gly Ile Leu 
    2180                 2185                 2190             


Lys Ala  Gly Gly Ala Tyr Leu  Gly Leu Asp Pro Glu  His Pro Ser 
    2195                 2200                 2205             


Glu Arg  Leu Ala Tyr Met Leu  Glu Asp Gly Gly Val  Lys Val Val 
    2210                 2215                 2220             


Leu Val  Gln Lys His Leu Leu  Pro Leu Val Gly Glu  Gly Leu Met 
    2225                 2230                 2235             


Pro Ile  Val Leu Glu Glu Glu  Ser Leu Arg Pro Glu  Asp Cys Gly 
    2240                 2245                 2250             


Asn Pro  Ala Ile Val Asn Gly  Ala Ser Asp Leu Ala  Tyr Val Met 
    2255                 2260                 2265             


Tyr Thr  Ser Gly Ser Thr Gly  Lys Pro Lys Gly Val  Met Val Glu 
    2270                 2275                 2280             


His Arg  Asn Val Thr Arg Leu  Val Met His Thr Asn  Tyr Val Gln 
    2285                 2290                 2295             


Val Arg  Glu Ser Asp Arg Met  Ile Gln Thr Gly Ala  Ile Gly Phe 
    2300                 2305                 2310             


Asp Ala  Met Thr Phe Glu Ile  Phe Gly Ala Leu Leu  His Gly Ala 
    2315                 2320                 2325             


Ser Leu  Tyr Leu Val Ser Lys  Asp Val Leu Leu Asp  Ala Glu Lys 
    2330                 2335                 2340             


Leu Gly  Asp Phe Leu Arg Thr  Asn Gln Ile Thr Thr  Met Trp Leu 
    2345                 2350                 2355             


Thr Ser  Pro Leu Phe Asn Gln  Leu Ser Gln Asp Asn  Pro Ala Met 
    2360                 2365                 2370             


Phe Asp  Ser Leu Arg Ala Leu  Ile Val Gly Gly Glu  Ala Leu Ser 
    2375                 2380                 2385             


Pro Lys  His Ile Asn Arg Val  Lys Ser Ala Leu Pro  Asp Leu Glu 
    2390                 2395                 2400             


Ile Trp  Asn Gly Tyr Gly Pro  Thr Glu Asn Thr Thr  Phe Ser Thr 
    2405                 2410                 2415             


Cys Tyr  Leu Ile Glu Gln His  Phe Glu Glu Gln Ile  Pro Ile Gly 
    2420                 2425                 2430             


Lys Pro  Ile Ala Asn Ser Thr  Ala Tyr Ile Val Asp  Gly Asn Asn 
    2435                 2440                 2445             


Gln Pro  Gln Pro Ile Gly Val  Pro Gly Glu Leu Cys  Val Gly Gly 
    2450                 2455                 2460             


Asp Gly  Val Ala Arg Gly Tyr  Val Asn Lys Pro Glu  Leu Thr Ala 
    2465                 2470                 2475             


Glu Lys  Phe Val Pro Asn Pro  Phe Ala Pro Gly Glu  Thr Met Tyr 
    2480                 2485                 2490             


Arg Thr  Gly Asp Leu Ala Arg  Trp Leu Pro Asp Gly  Thr Ile Glu 
    2495                 2500                 2505             


Tyr Leu  Gly Arg Ile Asp Gln  Gln Val Lys Ile Arg  Gly Tyr Arg 
    2510                 2515                 2520             


Ile Glu  Leu Gly Glu Ile Glu  Thr Val Leu Ser Gln  Gln Ala Gln 
    2525                 2530                 2535             


Val Lys  Glu Ala Val Val Ala  Val Ile Glu Glu Ala  Asn Gly Gln 
    2540                 2545                 2550             


Lys Ala  Leu Cys Ala Tyr Phe  Val Pro Glu Gln Ala  Val Asp Ala 
    2555                 2560                 2565             


Ala Glu  Leu Arg Glu Ala Met  Ser Lys Gln Leu Pro  Gly Tyr Met 
    2570                 2575                 2580             


Val Pro  Ala Tyr Tyr Val Gln  Met Glu Lys Leu Pro  Leu Thr Ala 
    2585                 2590                 2595             


Asn Gly  Lys Val Asp Arg Arg  Ala Leu Pro Gln Pro  Ser Gly Glu 
    2600                 2605                 2610             


Arg Thr  Thr Gly Ser Ala Phe  Val Ala Ala Gln Asn  Asp Thr Glu 
    2615                 2620                 2625             


Ala Lys  Leu Gln Gln Ile Trp  Gln Glu Val Leu Gly  Ile Pro Ala 
    2630                 2635                 2640             


Ile Gly  Ile His Asp Asn Phe  Phe Glu Ile Gly Gly  His Ser Leu 
    2645                 2650                 2655             


Lys Ala  Met Asn Val Ile Thr  Gln Val His Lys Thr  Phe Gln Val 
    2660                 2665                 2670             


Glu Leu  Pro Leu Lys Ala Leu  Phe Ala Thr Pro Thr  Ile His Glu 
    2675                 2680                 2685             


Leu Ala  Ala His Ile Ser Glu  Lys Thr Glu Tyr Thr  Ala Ile Gln 
    2690                 2695                 2700             


Pro Val  Ala Ala Gln Glu Phe  Tyr Pro Val Ser Ser  Ala Gln Lys 
    2705                 2710                 2715             


Arg Met  Tyr Ile Leu Gln Gln  Phe Glu Gly Asn Gly  Ile Ser Tyr 
    2720                 2725                 2730             


Asn Ile  Ser Gly Ala Ile Leu  Leu Glu Gly Lys Leu  Asp Tyr Ala 
    2735                 2740                 2745             


Arg Phe  Ala Ser Ala Val Gln  Gln Leu Ala Glu Arg  His Glu Ala 
    2750                 2755                 2760             


Leu Arg  Thr Ser Phe His Arg  Ile Asp Gly Glu Pro  Val Gln Lys 
    2765                 2770                 2775             


Val His  Glu Glu Val Glu Val  Pro Leu Phe Met Leu  Glu Ala Pro 
    2780                 2785                 2790             


Glu Asp  Gln Ala Glu Lys Ile  Met Arg Glu Phe Val  Arg Pro Phe 
    2795                 2800                 2805             


Asp Leu  Gly Val Ala Pro Leu  Met Arg Thr Gly Leu  Leu Lys Leu 
    2810                 2815                 2820             


Gly Lys  Asp Arg His Leu Phe  Leu Leu Asp Met His  His Ile Ile 
    2825                 2830                 2835             


Ser Asp  Gly Val Ser Ser Gln  Ile Leu Leu Arg Glu  Phe Ala Glu 
    2840                 2845                 2850             


Leu Tyr  Gln Gly Ala Asp Leu  Gln Pro Leu Ser Leu  Gln Tyr Lys 
    2855                 2860                 2865             


Asp Phe  Ala Ala Trp Gln Asn  Glu Leu Phe Gln Thr  Glu Ala Tyr 
    2870                 2875                 2880             


Lys Lys  Gln Glu Gln His Trp  Leu Asn Thr Phe Ala  Asp Glu Ile 
    2885                 2890                 2895             


Pro Leu  Leu Asn Leu Pro Thr  Asp Tyr Pro Arg Pro  Ser Val Gln 
    2900                 2905                 2910             


Ser Phe  Ala Gly Asp Leu Val  Leu Phe Ala Ala Gly  Lys Glu Leu 
    2915                 2920                 2925             


Leu Glu  Arg Leu Gln Gln Val  Ala Ser Glu Thr Gly  Thr Thr Leu 
    2930                 2935                 2940             


Tyr Met  Ile Leu Leu Ala Ala  Tyr Asn Val Leu Leu  Ser Lys Tyr 
    2945                 2950                 2955             


Thr Gly  Gln Glu Asp Ile Ile  Val Gly Thr Pro Val  Ala Gly Arg 
    2960                 2965                 2970             


Ser His  Ala Asp Val Glu Asn  Ile Met Gly Ile Phe  Val Asn Thr 
    2975                 2980                 2985             


Leu Ala  Leu Arg Asn Gln Pro  Ala Ser Ser Lys Thr  Met Leu Glu 
    2990                 2995                 3000             


Asn Asn  Ile Thr Gln Cys Asp  Ser Ile Asn Asp Val  Tyr Leu Lys 
    3005                 3010                 3015             


Glu Glu  Ala Ile Thr Leu Met  Asp Met Leu Glu Ser  Gln Leu Lys 
    3020                 3025                 3030             


His Gln  Ala Asp Gly Tyr Val  Val Ile Asp Gln Glu  Glu Ser Leu 
    3035                 3040                 3045             


Ser Tyr  Ala Asp Phe Tyr Leu  Arg Val Lys Glu Ile  Gly Tyr Cys 
    3050                 3055                 3060             


Leu Ser  Glu Ile Ser Ser Lys  Asn Ser Val Gly Ile  Gly Leu Phe 
    3065                 3070                 3075             


Cys Asp  Pro Ser Ile Asp Leu  Ile Cys Gly Ala Trp  Gly Ile Leu 
    3080                 3085                 3090             


Ser Ala  Asp Lys Ala Tyr Leu  Pro Leu Ser Pro Asp  Tyr Pro Thr 
    3095                 3100                 3105             


Glu Arg  Leu Lys Tyr Met Ile  Glu Asp Ser Gly Ile  Asp Val Ile 
    3110                 3115                 3120             


Phe Thr  Gln Ser His Leu Lys  Ala Gln Leu Gln Asp  Ile Ala Pro 
    3125                 3130                 3135             


Lys Ser  Val Leu Ile Met Thr  Pro Glu Asp Val Ala  Leu Thr Ile 
    3140                 3145                 3150             


Lys Thr  Arg Thr Ile Glu Asp  Ile Leu Gly Thr Val  Gln Val Pro 
    3155                 3160                 3165             


Lys Pro  Thr Ser Leu Ala Tyr  Ile Ile Tyr Thr Ser  Gly Ser Thr 
    3170                 3175                 3180             


Gly Lys  Pro Lys Gly Val Met  Ile Glu His His Ser  Ile Val Asn 
    3185                 3190                 3195             


Gln Met  Arg Phe Leu Ala Lys  Ala Phe Lys Leu Gly  Cys His Ser 
    3200                 3205                 3210             


Arg Ile  Leu Gln Lys Thr Pro  Met Ser Phe Asp Ala  Ala Gln Trp 
    3215                 3220                 3225             


Glu Ile  Leu Ala Pro Ala Ile  Gly Gly Gln Val Ile  Met Gly Pro 
    3230                 3235                 3240             


Leu Gly  Cys Tyr Arg Asp Pro  Asp Ala Ile Ile Lys  Thr Ile Leu 
    3245                 3250                 3255             


Gln His  Gln Val Thr Thr Leu  Gln Cys Val Pro Thr  Leu Leu Gln 
    3260                 3265                 3270             


Ala Leu  Leu Asp Asn Pro Asn  Phe Leu Asp Cys Leu  Ser Leu Thr 
    3275                 3280                 3285             


Gln Val  Phe Ser Gly Gly Glu  Ala Leu Thr Thr Lys  Leu Ala Thr 
    3290                 3295                 3300             


Gln Phe  Leu Asn Ser Phe Thr  His Cys Glu Leu Ile  Asn Leu Tyr 
    3305                 3310                 3315             


Gly Pro  Thr Glu Cys Thr Ile  Asn Ser Ser Phe Phe  Arg Val Thr 
    3320                 3325                 3330             


Asn Glu  Thr Leu Pro Asn Tyr  Gln Thr Ser Ile Ser  Ile Gly Ala 
    3335                 3340                 3345             


Pro Val  Asp Asn Thr Glu Tyr  Tyr Val Leu Asp Asp  Asp Arg Leu 
    3350                 3355                 3360             


Pro Val  Ala Val Gly Glu Ile  Gly Glu Leu Tyr Ile  Ser Gly Ala 
    3365                 3370                 3375             


Gln Leu  Ala Arg Gly Tyr Leu  His Lys Pro Glu Met  Thr Lys Asp 
    3380                 3385                 3390             


Lys Phe  Ile Cys Asn His Leu  Val Ser Gly Thr Gln  His Gln Trp 
    3395                 3400                 3405             


Leu Tyr  Arg Thr Gly Asp Leu  Val Thr Arg Gly Ala  Asp Gly Asn 
    3410                 3415                 3420             


Thr Tyr  Phe Val Gly Arg Val  Asp Ser Gln Val Lys  Leu Arg Gly 
    3425                 3430                 3435             


Tyr Arg  Ile Glu Leu Asp Glu  Ile Arg His Ala Ile  Glu Glu His 
    3440                 3445                 3450             


Ser Trp  Ile Lys Thr Ala Ala  Met Leu Ile Lys Lys  Asp Ala Arg 
    3455                 3460                 3465             


Thr Gly  Phe Gln Asn Leu Ile  Ala Cys Val Glu Leu  Asp Glu Lys 
    3470                 3475                 3480             


Glu Ala  Ala Leu Met Asp Gln  Gly Asn Ser Ser Ser  His His Lys 
    3485                 3490                 3495             


Ser Lys  Ala Asp Lys Leu Gln  Val Lys Ala Gln Leu  Ser Asn Ser 
    3500                 3505                 3510             


Gly Cys  Arg Ser Glu Glu Leu  Cys Glu Asn Arg Pro  Thr Phe Leu 
    3515                 3520                 3525             


Leu Pro  Tyr Gln Glu Gly Glu  Ile Lys Gln Arg Glu  Tyr Ala Phe 
    3530                 3535                 3540             


Gly Arg  Lys Thr Tyr Arg Tyr  Phe Glu Gly Thr Glu  Ile Thr Val 
    3545                 3550                 3555             


Glu Lys  Leu Lys Lys Leu Leu  Thr Ala Thr Gln Ser  Asn Glu Ile 
    3560                 3565                 3570             


Ser Ser  Leu Pro Leu Ser His  Leu Thr Leu Asn Asp  Phe Gly Tyr 
    3575                 3580                 3585             


Ala Leu  Arg Tyr Phe Gly Gln  Phe Thr Ser His Gln  Arg Leu Leu 
    3590                 3595                 3600             


Pro Lys  Tyr Ala Tyr Ala Ser  Pro Gly Ala Leu Tyr  Ala Thr Gln 
    3605                 3610                 3615             


Met Tyr  Phe Glu Leu His Asn  Val Leu Gly Leu Asp  Ala Gly Ile 
    3620                 3625                 3630             


Tyr Tyr  Tyr His Pro Val Thr  His Lys Leu Ile Lys  Ile Ser Thr 
    3635                 3640                 3645             


Leu Ser  Arg Arg Gln Met Pro  Thr Ile Lys Val His  Phe Ile Gly 
    3650                 3655                 3660             


Lys His  Glu Ala Ile Glu Pro  Val Tyr Lys Asn Asn  Ile Gln Glu 
    3665                 3670                 3675             


Val Leu  Glu Met Glu Ala Gly  His Met Met Gly Leu  Phe Asp Asp 
    3680                 3685                 3690             


Val Leu  Pro Glu Ile Gly Leu  Ser Ile Gly Lys Ser  Glu Tyr Gln 
    3695                 3700                 3705             


Asp Glu  Cys Pro Asp Trp Tyr  Asp Gly Asp Ile Gln  Asp Tyr Tyr 
    3710                 3715                 3720             


Leu Gly  Ala Phe Glu Ile Cys  Ser Tyr Glu His Gly  Leu Pro Pro 
    3725                 3730                 3735             


Phe Glu  Thr Asp Ile Tyr Leu  Gln Thr His Ala His  Lys Ile Pro 
    3740                 3745                 3750             


Glu Met  Pro Cys Gly Leu Tyr  His Phe Ser Asn Gly  Glu Phe Val 
    3755                 3760                 3765             


Arg Ile  Ser Asp Asp Ile Val  Arg Lys Lys Asp Val  Ile Ala Ile 
    3770                 3775                 3780             


Asn Gln  Gln Val Tyr Asp Arg  Ser Ser Phe Gly Val  Ser Ile Ile 
    3785                 3790                 3795             


Pro Arg  Cys Val Pro Glu Trp  His Tyr Tyr Ile Thr  Leu Gly Arg 
    3800                 3805                 3810             


Arg Leu  His Ala Leu Gln Ser  Asn Pro Leu Tyr Ile  Gly Leu Met 
    3815                 3820                 3825             


Ser Ser  Gly Tyr Ser Ser Lys  Ser Asn Asn Asp Leu  Pro Ser Ala 
    3830                 3835                 3840             


Lys Arg  Met Arg Ser Ile Leu  Asn Ala Leu Asp Arg  Pro Met Ala 
    3845                 3850                 3855             


Ala Phe  Tyr Phe Cys Ile Gly  Gly Gly Ile Ser Gln  Ala Gln Tyr 
    3860                 3865                 3870             


Met Cys  Glu Gly Met Lys Glu  Asp Val Val His Met  Lys Gly Pro 
    3875                 3880                 3885             


Val Glu  Ile Ile Lys Asp Asp  Leu Gln Gln Gln Leu  Pro Gln Tyr 
    3890                 3895                 3900             


Met Ile  Pro Asn Lys Val Leu  Val Phe Asp Lys Leu  Pro Leu Thr 
    3905                 3910                 3915             


Ala Asn  Gly Lys Val Asp Tyr  Gln Ser Leu Ser Glu  Ser Lys Ala 
    3920                 3925                 3930             


Val Glu  Asn Val Ser Thr Gln  Arg Leu Leu Val Pro  Leu His Thr 
    3935                 3940                 3945             


Asp Thr  Glu Ile Arg Leu Gly  Lys Ile Trp Met Glu  Val Leu Lys 
    3950                 3955                 3960             


Trp Asp  Ser Val Ser Ala Leu  Asp Asp Phe Phe Glu  Ser Gly Gly 
    3965                 3970                 3975             


Asn Ser  Leu Met Ala Val Ala  Met Val Asn Lys Ile  Asn Ala Ala 
    3980                 3985                 3990             


Phe Asn  Ile Arg Phe Pro Leu  Gln Ile Leu Phe Gln  Ser Pro Asn 
    3995                 4000                 4005             


Ile Ala  Glu Leu Ala Lys Trp  Ile Glu Gln Thr Asp  Ser Lys Thr 
    4010                 4015                 4020             


Ile Ser  Arg Leu Ile Leu Leu  Asn Gln Ala Ser Lys  Asp Pro Ile 
    4025                 4030                 4035             


Tyr Cys  Trp Pro Gly Leu Gly  Gly Tyr Pro Met Ser  Leu Arg Leu 
    4040                 4045                 4050             


Leu Ala  Asn Lys Val Val Pro  Asp Arg Ala Phe Tyr  Gly Ile Gln 
    4055                 4060                 4065             


Ala Tyr  Gly Ile Asn Glu Ser  Glu Ile Pro Phe Ser  Ser Ile Gln 
    4070                 4075                 4080             


Arg Met  Ala Glu Glu Asp Ile  Lys Glu Ile Lys Lys  Ile Gln Pro 
    4085                 4090                 4095             


Glu Gly  Pro Tyr Ile Leu Trp  Gly Tyr Ser Phe Gly  Ala Arg Val 
    4100                 4105                 4110             


Ala Phe  Glu Val Ala Tyr Gln  Leu Glu Gln Ala Gly  Glu Glu Val 
    4115                 4120                 4125             


Asn Ala  Leu Asn Leu Leu Ala  Pro Gly Ser Pro His  Leu Asp Met 
    4130                 4135                 4140             


Lys Gln  Ala Glu Tyr Met Asp  Lys Gly Ala Glu Phe  Thr Asn Pro 
    4145                 4150                 4155             


Ala Phe  Val Lys Ile Leu Phe  Ser Val Phe Ser Arg  Ser Ile Asn 
    4160                 4165                 4170             


Ser Pro  Met Val Lys Thr Cys  Leu Glu Gln Val Asn  Ser Glu Thr 
    4175                 4180                 4185             


Thr Phe  Ile Asn Phe Ile Cys  Ser Arg Phe Lys Asn  Leu Glu Pro 
    4190                 4195                 4200             


Ser Leu  Val Lys Arg Ile Val  Arg Ile Val Thr Leu  Thr Tyr Asp 
    4205                 4210                 4215             


Phe Lys  Tyr Ser Ile Asp Glu  Leu Tyr His Arg His  Leu Lys Ala 
    4220                 4225                 4230             


Pro Ile  Thr Ile Phe Lys Ala  Asn Arg Asp Asn Asp  Ser Phe Ile 
    4235                 4240                 4245             


Glu Glu  Ser Asp Val Ile Ser  Ser Met Ser Pro Lys  Ile Ile Glu 
    4250                 4255                 4260             


Leu Ile  Ser Asp His Tyr Gln  Leu Leu Glu Ser Glu  Gly Val Ala 
    4265                 4270                 4275             


Glu Ile  Glu Lys Ile Ile 
    4280                 


<210>  35
<211>  2168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPS being a synthetase of a fusion peptide consisting of Valine 
       and Indigoidine. Due to its sterical advantages, Valine may be 
       used as a spacer between the indigoidine pigment and the NRPS 
       oligopeptide of interest to be tagged with the pigment.

<400>  35

Met Tyr Pro Arg Asp Leu Thr Ile Gln Glu Leu Phe Glu Gln Gln Ala 
1               5                   10                  15      


Ala Lys Thr Pro Glu His Ala Ala Val Val Met Asp Gly Gln Met Leu 
            20                  25                  30          


Thr Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Leu Ala His Val Leu 
        35                  40                  45              


Arg Gln Asn Gly Val Gly Lys Glu Ser Ile Val Gly Leu Leu Ala Asp 
    50                  55                  60                  


Arg Ser Leu Glu Met Ile Thr Gly Ile Met Gly Ile Leu Lys Ala Gly 
65                  70                  75                  80  


Gly Ala Tyr Leu Gly Leu Asp Pro Glu His Pro Ser Glu Arg Leu Ala 
                85                  90                  95      


Tyr Met Leu Glu Asp Gly Gly Val Lys Val Val Leu Val Gln Lys His 
            100                 105                 110         


Leu Leu Pro Leu Val Gly Glu Gly Leu Met Pro Ile Val Leu Glu Glu 
        115                 120                 125             


Glu Ser Leu Arg Pro Glu Asp Cys Gly Asn Pro Ala Ile Val Asn Gly 
    130                 135                 140                 


Ala Ser Asp Leu Ala Tyr Val Met Tyr Thr Ser Gly Ser Thr Gly Lys 
145                 150                 155                 160 


Pro Lys Gly Val Met Val Glu His Arg Asn Val Thr Arg Leu Val Met 
                165                 170                 175     


His Thr Asn Tyr Val Gln Val Arg Glu Ser Asp Arg Met Ile Gln Thr 
            180                 185                 190         


Gly Ala Ile Gly Phe Asp Ala Met Thr Phe Glu Ile Phe Gly Ala Leu 
        195                 200                 205             


Leu His Gly Ala Ser Leu Tyr Leu Val Ser Lys Asp Val Leu Leu Asp 
    210                 215                 220                 


Ala Glu Lys Leu Gly Asp Phe Leu Arg Thr Asn Gln Ile Thr Thr Met 
225                 230                 235                 240 


Trp Leu Thr Ser Pro Leu Phe Asn Gln Leu Ser Gln Asp Asn Pro Ala 
                245                 250                 255     


Met Phe Asp Ser Leu Arg Ala Leu Ile Val Gly Gly Glu Ala Leu Ser 
            260                 265                 270         


Pro Lys His Ile Asn Arg Val Lys Ser Ala Leu Pro Asp Leu Glu Ile 
        275                 280                 285             


Trp Asn Gly Tyr Gly Pro Thr Glu Asn Thr Thr Phe Ser Thr Cys Tyr 
    290                 295                 300                 


Leu Ile Glu Gln His Phe Glu Glu Gln Ile Pro Ile Gly Lys Pro Ile 
305                 310                 315                 320 


Ala Asn Ser Thr Ala Tyr Ile Val Asp Gly Asn Asn Gln Pro Gln Pro 
                325                 330                 335     


Ile Gly Val Pro Gly Glu Leu Cys Val Gly Gly Asp Gly Val Ala Arg 
            340                 345                 350         


Gly Tyr Val Asn Lys Pro Glu Leu Thr Ala Glu Lys Phe Val Pro Asn 
        355                 360                 365             


Pro Phe Ala Pro Gly Glu Thr Met Tyr Arg Thr Gly Asp Leu Ala Arg 
    370                 375                 380                 


Trp Leu Pro Asp Gly Thr Ile Glu Tyr Leu Gly Arg Ile Asp Gln Gln 
385                 390                 395                 400 


Val Lys Ile Arg Gly Tyr Arg Ile Glu Leu Gly Glu Ile Glu Thr Val 
                405                 410                 415     


Leu Ser Gln Gln Ala Gln Val Lys Glu Ala Val Val Ala Val Ile Glu 
            420                 425                 430         


Glu Ala Asn Gly Gln Lys Ala Leu Cys Ala Tyr Phe Val Pro Glu Gln 
        435                 440                 445             


Ala Val Asp Ala Ala Glu Leu Arg Glu Ala Met Ser Lys Gln Leu Pro 
    450                 455                 460                 


Gly Tyr Met Val Pro Ala Tyr Tyr Val Gln Met Glu Lys Leu Pro Leu 
465                 470                 475                 480 


Thr Ala Asn Gly Lys Val Asp Arg Arg Ala Leu Pro Gln Pro Ser Gly 
                485                 490                 495     


Glu Arg Thr Thr Gly Ser Ala Phe Val Ala Ala Gln Asn Asp Thr Glu 
            500                 505                 510         


Ala Lys Leu Gln Gln Ile Trp Gln Glu Val Leu Gly Ile Pro Ala Ile 
        515                 520                 525             


Gly Ile His Asp Asn Phe Phe Glu Ile Gly Gly His Ser Leu Lys Ala 
    530                 535                 540                 


Met Asn Val Ile Thr Gln Val His Lys Thr Phe Gln Val Glu Leu Pro 
545                 550                 555                 560 


Leu Lys Ala Leu Phe Ala Thr Pro Thr Ile His Glu Leu Ala Ala His 
                565                 570                 575     


Ile Ser Glu Lys Thr Glu Tyr Thr Ala Ile Gln Pro Val Ala Ala Gln 
            580                 585                 590         


Glu Phe Tyr Pro Val Ser Ser Ala Gln Lys Arg Met Tyr Ile Leu Gln 
        595                 600                 605             


Gln Phe Glu Gly Asn Gly Ile Ser Tyr Asn Ile Ser Gly Ala Ile Leu 
    610                 615                 620                 


Leu Glu Gly Lys Leu Asp Tyr Ala Arg Phe Ala Ser Ala Val Gln Gln 
625                 630                 635                 640 


Leu Ala Glu Arg His Glu Ala Leu Arg Thr Ser Phe His Arg Ile Asp 
                645                 650                 655     


Gly Glu Pro Val Gln Lys Val His Glu Glu Val Glu Val Pro Leu Phe 
            660                 665                 670         


Met Leu Glu Ala Pro Glu Asp Gln Ala Glu Lys Ile Met Arg Glu Phe 
        675                 680                 685             


Val Arg Pro Phe Asp Leu Gly Val Ala Pro Leu Met Arg Thr Gly Leu 
    690                 695                 700                 


Leu Lys Leu Gly Lys Asp Arg His Leu Phe Leu Leu Asp Met His His 
705                 710                 715                 720 


Ile Ile Ser Asp Gly Val Ser Ser Gln Ile Leu Leu Arg Glu Phe Ala 
                725                 730                 735     


Glu Leu Tyr Gln Gly Ala Asp Leu Gln Pro Leu Ser Leu Gln Tyr Lys 
            740                 745                 750         


Asp Phe Ala Ala Trp Gln Asn Glu Leu Phe Gln Thr Glu Ala Tyr Lys 
        755                 760                 765             


Lys Gln Glu Gln His Trp Leu Asn Thr Phe Ala Asp Glu Ile Pro Leu 
    770                 775                 780                 


Leu Asn Leu Pro Thr Asp Tyr Pro Arg Pro Ser Val Gln Ser Phe Ala 
785                 790                 795                 800 


Gly Asp Leu Val Leu Phe Ala Ala Gly Lys Glu Leu Leu Glu Arg Leu 
                805                 810                 815     


Gln Gln Val Ala Ser Glu Thr Gly Thr Thr Leu Tyr Met Ile Leu Leu 
            820                 825                 830         


Ala Ala Tyr Asn Val Leu Leu Ser Lys Tyr Thr Gly Gln Glu Asp Ile 
        835                 840                 845             


Ile Val Gly Thr Pro Val Ala Gly Arg Ser His Ala Asp Val Glu Asn 
    850                 855                 860                 


Ile Met Gly Ile Phe Val Asn Thr Leu Ala Leu Arg Asn Gln Pro Ala 
865                 870                 875                 880 


Ser Ser Lys Thr Met Leu Glu Asn Asn Ile Thr Gln Cys Asp Ser Ile 
                885                 890                 895     


Asn Asp Val Tyr Leu Lys Glu Glu Ala Ile Thr Leu Met Asp Met Leu 
            900                 905                 910         


Glu Ser Gln Leu Lys His Gln Ala Asp Gly Tyr Val Val Ile Asp Gln 
        915                 920                 925             


Glu Glu Ser Leu Ser Tyr Ala Asp Phe Tyr Leu Arg Val Lys Glu Ile 
    930                 935                 940                 


Gly Tyr Cys Leu Ser Glu Ile Ser Ser Lys Ser Ser Val Gly Ile Gly 
945                 950                 955                 960 


Leu Phe Cys Asp Pro Ser Ile Asp Leu Ile Cys Gly Ala Trp Gly Ile 
                965                 970                 975     


Leu Ser Ala Asp Lys Ala Tyr Leu Pro Leu Ser Pro Asp Tyr Pro Thr 
            980                 985                 990         


Glu Arg Leu Lys Tyr Met Ile Glu  Asp Ser Gly Ile Asp  Val Ile Phe 
        995                 1000                 1005             


Thr Gln  Ser His Leu Lys Ala  Gln Leu Gln Asp Ile  Ala Pro Lys 
    1010                 1015                 1020             


Ser Val  Leu Ile Met Thr Pro  Glu Asp Val Ala Leu  Thr Ile Lys 
    1025                 1030                 1035             


Thr Arg  Thr Ile Glu Asp Ile  Leu Gly Thr Val Gln  Val Pro Lys 
    1040                 1045                 1050             


Pro Thr  Ser Leu Ala Tyr Ile  Ile Tyr Thr Ser Gly  Ser Thr Gly 
    1055                 1060                 1065             


Lys Pro  Lys Gly Val Met Ile  Glu His His Ser Ile  Val Asn Gln 
    1070                 1075                 1080             


Met Arg  Phe Leu Ala Lys Ala  Phe Lys Leu Gly Cys  His Ser Arg 
    1085                 1090                 1095             


Ile Leu  Gln Lys Thr Pro Met  Ser Phe Asp Ala Ala  Gln Trp Glu 
    1100                 1105                 1110             


Ile Leu  Ala Pro Ala Ile Gly  Gly Gln Val Ile Met  Gly Pro Leu 
    1115                 1120                 1125             


Gly Cys  Tyr Arg Asp Pro Asp  Ala Ile Ile Lys Thr  Ile Leu Gln 
    1130                 1135                 1140             


His Gln  Val Thr Thr Leu Gln  Cys Val Pro Thr Leu  Leu Gln Ala 
    1145                 1150                 1155             


Leu Leu  Asp Asn Pro Asn Phe  Leu Asp Cys Leu Ser  Leu Thr Gln 
    1160                 1165                 1170             


Val Phe  Ser Gly Gly Glu Ala  Leu Thr Thr Lys Leu  Ala Thr Gln 
    1175                 1180                 1185             


Phe Leu  Asn Ser Phe Thr His  Cys Glu Leu Ile Asn  Leu Tyr Gly 
    1190                 1195                 1200             


Pro Thr  Glu Cys Thr Ile Asn  Ser Ser Phe Phe Arg  Val Thr Asn 
    1205                 1210                 1215             


Glu Thr  Leu Pro Asn Tyr Gln  Thr Ser Ile Ser Ile  Gly Ala Pro 
    1220                 1225                 1230             


Val Asp  Asn Thr Glu Tyr Tyr  Val Leu Asp Asp Asp  Arg Leu Pro 
    1235                 1240                 1245             


Val Ala  Val Gly Glu Ile Gly  Glu Leu Tyr Ile Ser  Gly Ala Gln 
    1250                 1255                 1260             


Leu Ala  Arg Gly Tyr Leu His  Lys Pro Glu Met Thr  Lys Asp Lys 
    1265                 1270                 1275             


Phe Ile  Cys Asn His Leu Val  Ser Gly Thr Gln His  Gln Trp Leu 
    1280                 1285                 1290             


Tyr Arg  Thr Gly Asp Leu Val  Thr Arg Gly Ala Asp  Gly Asn Thr 
    1295                 1300                 1305             


Tyr Phe  Val Gly Arg Val Asp  Ser Gln Val Lys Leu  Arg Gly Tyr 
    1310                 1315                 1320             


Arg Ile  Glu Leu Asp Glu Ile  Arg His Ala Ile Glu  Glu His Ser 
    1325                 1330                 1335             


Trp Ile  Lys Thr Ala Ala Met  Leu Ile Lys Lys Asp  Ala Arg Thr 
    1340                 1345                 1350             


Gly Phe  Gln Asn Leu Ile Ala  Cys Val Glu Leu Asp  Glu Lys Glu 
    1355                 1360                 1365             


Ala Ala  Leu Met Asp Gln Gly  Asn Ser Ser Ser His  His Lys Ser 
    1370                 1375                 1380             


Lys Ala  Asp Lys Leu Gln Val  Lys Ala Gln Leu Ser  Asn Ser Gly 
    1385                 1390                 1395             


Cys Arg  Ser Glu Glu Leu Cys  Glu Asn Arg Pro Thr  Phe Leu Leu 
    1400                 1405                 1410             


Pro Tyr  Gln Glu Gly Glu Ile  Lys Gln Arg Glu Tyr  Ala Phe Gly 
    1415                 1420                 1425             


Arg Lys  Thr Tyr Arg Tyr Phe  Glu Gly Thr Glu Ile  Thr Val Glu 
    1430                 1435                 1440             


Lys Leu  Lys Lys Leu Leu Thr  Ala Thr Gln Ser Asn  Glu Ile Ser 
    1445                 1450                 1455             


Ser Leu  Pro Leu Ser His Leu  Thr Leu Asn Asp Phe  Gly Tyr Ala 
    1460                 1465                 1470             


Leu Arg  Tyr Phe Gly Gln Phe  Thr Ser His Gln Arg  Leu Leu Pro 
    1475                 1480                 1485             


Lys Tyr  Ala Tyr Ala Ser Pro  Gly Ala Leu Tyr Ala  Thr Gln Met 
    1490                 1495                 1500             


Tyr Phe  Glu Leu His Asn Val  Leu Gly Leu Asp Ala  Gly Ile Tyr 
    1505                 1510                 1515             


Tyr Tyr  His Pro Val Thr His  Lys Leu Ile Lys Ile  Ser Thr Leu 
    1520                 1525                 1530             


Ser Arg  Arg Gln Met Pro Thr  Ile Lys Val His Phe  Ile Gly Lys 
    1535                 1540                 1545             


His Glu  Ala Ile Glu Pro Val  Tyr Lys Asn Asn Ile  Gln Glu Val 
    1550                 1555                 1560             


Leu Glu  Met Glu Ala Gly His  Met Met Gly Leu Phe  Asp Asp Val 
    1565                 1570                 1575             


Leu Pro  Glu Ile Gly Leu Ser  Ile Gly Lys Ser Glu  Tyr Gln Asp 
    1580                 1585                 1590             


Glu Cys  Pro Asp Trp Tyr Asp  Gly Asp Ile Gln Asp  Tyr Tyr Leu 
    1595                 1600                 1605             


Gly Ala  Phe Glu Ile Cys Ser  Tyr Glu His Gly Leu  Pro Pro Phe 
    1610                 1615                 1620             


Glu Thr  Asp Ile Tyr Leu Gln  Thr His Ala His Lys  Ile Pro Glu 
    1625                 1630                 1635             


Met Pro  Cys Gly Leu Tyr His  Phe Ser Asn Gly Glu  Phe Val Arg 
    1640                 1645                 1650             


Ile Ser  Asp Asp Ile Val Arg  Lys Lys Asp Val Ile  Ala Ile Asn 
    1655                 1660                 1665             


Gln Gln  Val Tyr Asp Arg Ser  Ser Phe Gly Val Ser  Ile Ile Pro 
    1670                 1675                 1680             


Arg Cys  Val Pro Glu Trp His  Tyr Tyr Ile Thr Leu  Gly Arg Arg 
    1685                 1690                 1695             


Leu His  Ala Leu Gln Ser Asn  Pro Leu Tyr Ile Gly  Leu Met Ser 
    1700                 1705                 1710             


Ser Gly  Tyr Ser Ser Lys Ser  Asn Asn Asp Leu Pro  Ser Ala Lys 
    1715                 1720                 1725             


Arg Met  Arg Ser Ile Leu Asn  Ala Leu Asp Arg Pro  Met Ala Ala 
    1730                 1735                 1740             


Phe Tyr  Phe Cys Ile Gly Gly  Gly Ile Ser Gln Ala  Gln Tyr Met 
    1745                 1750                 1755             


Cys Glu  Gly Met Lys Glu Asp  Val Val His Met Lys  Gly Pro Val 
    1760                 1765                 1770             


Glu Ile  Ile Lys Asp Asp Leu  Gln Gln Gln Leu Pro  Gln Tyr Met 
    1775                 1780                 1785             


Ile Pro  Asn Lys Val Leu Val  Phe Asp Lys Leu Pro  Leu Thr Ala 
    1790                 1795                 1800             


Asn Gly  Lys Val Asp Tyr Gln  Ser Leu Ser Glu Ser  Lys Ala Val 
    1805                 1810                 1815             


Glu Asn  Val Ser Thr Gln Arg  Leu Leu Val Pro Leu  His Thr Asp 
    1820                 1825                 1830             


Thr Glu  Ile Arg Leu Gly Lys  Ile Trp Met Glu Val  Leu Lys Trp 
    1835                 1840                 1845             


Asp Ser  Val Ser Ala Leu Asp  Asp Phe Phe Glu Ser  Gly Gly Asn 
    1850                 1855                 1860             


Ser Leu  Met Ala Val Ala Met  Val Asn Lys Ile Asn  Ala Ala Phe 
    1865                 1870                 1875             


Asn Ile  Arg Phe Pro Leu Gln  Ile Leu Phe Gln Ser  Pro Asn Ile 
    1880                 1885                 1890             


Ala Glu  Leu Ala Lys Trp Ile  Glu Gln Thr Asp Ser  Lys Thr Ile 
    1895                 1900                 1905             


Ser Arg  Leu Ile Leu Leu Asn  Gln Ala Ser Lys Asp  Pro Ile Tyr 
    1910                 1915                 1920             


Cys Trp  Pro Gly Leu Gly Gly  Tyr Pro Met Ser Leu  Arg Leu Leu 
    1925                 1930                 1935             


Ala Asn  Lys Val Val Pro Asp  Arg Ala Phe Tyr Gly  Ile Gln Ala 
    1940                 1945                 1950             


Tyr Gly  Ile Asn Glu Ser Glu  Ile Pro Phe Ser Ser  Ile Gln Arg 
    1955                 1960                 1965             


Met Ala  Glu Glu Asp Ile Lys  Glu Ile Lys Lys Ile  Gln Pro Glu 
    1970                 1975                 1980             


Gly Pro  Tyr Ile Leu Trp Gly  Tyr Ser Phe Gly Ala  Arg Val Ala 
    1985                 1990                 1995             


Phe Glu  Val Ala Tyr Gln Leu  Glu Gln Ala Gly Glu  Glu Val Asn 
    2000                 2005                 2010             


Ala Leu  Asn Leu Leu Ala Pro  Gly Ser Pro His Leu  Asp Met Lys 
    2015                 2020                 2025             


Gln Ala  Glu Tyr Met Asp Lys  Gly Ala Glu Phe Thr  Asn Pro Ala 
    2030                 2035                 2040             


Phe Val  Lys Ile Leu Phe Ser  Val Phe Ser Arg Ser  Ile Asn Ser 
    2045                 2050                 2055             


Pro Met  Val Lys Thr Cys Leu  Glu Gln Val Asn Ser  Glu Thr Thr 
    2060                 2065                 2070             


Phe Ile  Asn Phe Ile Cys Ser  Arg Phe Lys Asn Leu  Glu Pro Ser 
    2075                 2080                 2085             


Leu Val  Lys Arg Ile Val Arg  Ile Val Thr Leu Thr  Tyr Asp Phe 
    2090                 2095                 2100             


Lys Tyr  Ser Ile Asp Glu Leu  Tyr His Arg His Leu  Lys Ala Pro 
    2105                 2110                 2115             


Ile Thr  Ile Phe Lys Ala Asn  Arg Asp Asn Asp Ser  Phe Ile Glu 
    2120                 2125                 2130             


Glu Ser  Asp Val Ile Ser Ser  Met Ser Pro Lys Ile  Ile Glu Leu 
    2135                 2140                 2145             


Ile Ser  Asp His Tyr Gln Leu  Leu Glu Ser Glu Gly  Val Ala Glu 
    2150                 2155                 2160             


Ile Glu  Lys Ile Ile 
    2165             


<210>  36
<211>  3202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRPSase synthesizing a Indigoidine-tagged Dipeptide consisting of
       two Valine-monomers.

<400>  36

Met Tyr Pro Arg Asp Leu Thr Ile Gln Glu Leu Phe Glu Gln Gln Ala 
1               5                   10                  15      


Ala Lys Thr Pro Glu His Ala Ala Val Val Met Asp Gly Gln Met Leu 
            20                  25                  30          


Thr Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Leu Ala His Val Leu 
        35                  40                  45              


Arg Gln Asn Gly Val Gly Lys Glu Ser Ile Val Gly Leu Leu Ala Asp 
    50                  55                  60                  


Arg Ser Leu Glu Met Ile Thr Gly Ile Met Gly Ile Leu Lys Ala Gly 
65                  70                  75                  80  


Gly Ala Tyr Leu Gly Leu Asp Pro Glu His Pro Ser Glu Arg Leu Ala 
                85                  90                  95      


Tyr Met Leu Glu Asp Gly Gly Val Lys Val Val Leu Val Gln Lys His 
            100                 105                 110         


Leu Leu Pro Leu Val Gly Glu Gly Leu Met Pro Ile Val Leu Glu Glu 
        115                 120                 125             


Glu Ser Leu Arg Pro Glu Asp Cys Gly Asn Pro Ala Ile Val Asn Gly 
    130                 135                 140                 


Ala Ser Asp Leu Ala Tyr Val Met Tyr Thr Ser Gly Ser Thr Gly Lys 
145                 150                 155                 160 


Pro Lys Gly Val Met Val Glu His Arg Asn Val Thr Arg Leu Val Met 
                165                 170                 175     


His Thr Asn Tyr Val Gln Val Arg Glu Ser Asp Arg Met Ile Gln Thr 
            180                 185                 190         


Gly Ala Ile Gly Phe Asp Ala Met Thr Phe Glu Ile Phe Gly Ala Leu 
        195                 200                 205             


Leu His Gly Ala Ser Leu Tyr Leu Val Ser Lys Asp Val Leu Leu Asp 
    210                 215                 220                 


Ala Glu Lys Leu Gly Asp Phe Leu Arg Thr Asn Gln Ile Thr Thr Met 
225                 230                 235                 240 


Trp Leu Thr Ser Pro Leu Phe Asn Gln Leu Ser Gln Asp Asn Pro Ala 
                245                 250                 255     


Met Phe Asp Ser Leu Arg Ala Leu Ile Val Gly Gly Glu Ala Leu Ser 
            260                 265                 270         


Pro Lys His Ile Asn Arg Val Lys Ser Ala Leu Pro Asp Leu Glu Ile 
        275                 280                 285             


Trp Asn Gly Tyr Gly Pro Thr Glu Asn Thr Thr Phe Ser Thr Cys Tyr 
    290                 295                 300                 


Leu Ile Glu Gln His Phe Glu Glu Gln Ile Pro Ile Gly Lys Pro Ile 
305                 310                 315                 320 


Ala Asn Ser Thr Ala Tyr Ile Val Asp Gly Asn Asn Gln Pro Gln Pro 
                325                 330                 335     


Ile Gly Val Pro Gly Glu Leu Cys Val Gly Gly Asp Gly Val Ala Arg 
            340                 345                 350         


Gly Tyr Val Asn Lys Pro Glu Leu Thr Ala Glu Lys Phe Val Pro Asn 
        355                 360                 365             


Pro Phe Ala Pro Gly Glu Thr Met Tyr Arg Thr Gly Asp Leu Ala Arg 
    370                 375                 380                 


Trp Leu Pro Asp Gly Thr Ile Glu Tyr Leu Gly Arg Ile Asp Gln Gln 
385                 390                 395                 400 


Val Lys Ile Arg Gly Tyr Arg Ile Glu Leu Gly Glu Ile Glu Thr Val 
                405                 410                 415     


Leu Ser Gln Gln Ala Gln Val Lys Glu Ala Val Val Ala Val Ile Glu 
            420                 425                 430         


Glu Ala Asn Gly Gln Lys Ala Leu Cys Ala Tyr Phe Val Pro Glu Gln 
        435                 440                 445             


Ala Val Asp Ala Ala Glu Leu Arg Glu Ala Met Ser Lys Gln Leu Pro 
    450                 455                 460                 


Gly Tyr Met Val Pro Ala Tyr Tyr Val Gln Met Glu Lys Leu Pro Leu 
465                 470                 475                 480 


Thr Ala Asn Gly Lys Val Asp Arg Arg Ala Leu Pro Gln Pro Ser Gly 
                485                 490                 495     


Glu Arg Thr Thr Gly Ser Ala Phe Val Ala Ala Gln Asn Asp Thr Glu 
            500                 505                 510         


Ala Lys Leu Gln Gln Ile Trp Gln Glu Val Leu Gly Ile Pro Ala Ile 
        515                 520                 525             


Gly Ile His Asp Asn Phe Phe Glu Ile Gly Gly His Ser Leu Lys Ala 
    530                 535                 540                 


Met Asn Val Ile Thr Gln Val His Lys Thr Phe Gln Val Glu Leu Pro 
545                 550                 555                 560 


Leu Lys Ala Leu Phe Ala Thr Pro Thr Ile His Glu Leu Ala Ala His 
                565                 570                 575     


Ile Ala Thr Ser Gly Lys Glu Thr Tyr Val Pro Ile Glu Pro Ala Pro 
            580                 585                 590         


Leu Gln Glu Tyr Tyr Pro Val Ser Ser Ala Gln Lys Arg Met Tyr Val 
        595                 600                 605             


Leu Arg Gln Phe Ala Asp Thr Gly Thr Val Tyr Asn Met Pro Ser Ala 
    610                 615                 620                 


Leu Tyr Ile Glu Gly Asp Leu Asp Arg Lys Arg Phe Glu Ala Ala Ile 
625                 630                 635                 640 


His Gly Leu Val Glu Arg His Glu Ser Leu Arg Thr Ser Phe His Thr 
                645                 650                 655     


Val Asn Gly Glu Pro Val Gln Arg Val His Glu His Val Glu Leu Asn 
            660                 665                 670         


Val Gln Tyr Ala Glu Val Thr Glu Ala Gln Val Glu Pro Thr Val Glu 
        675                 680                 685             


Ser Phe Val Gln Ala Phe Asp Leu Thr Lys Ala Pro Leu Leu Arg Val 
    690                 695                 700                 


Gly Leu Phe Lys Leu Ala Ala Lys Arg His Leu Phe Leu Leu Asp Met 
705                 710                 715                 720 


His His Ile Ile Ser Asp Gly Val Ser Ala Gly Ile Ile Met Glu Glu 
                725                 730                 735     


Phe Ser Lys Leu Tyr Arg Gly Glu Glu Leu Pro Ala Leu Ser Val His 
            740                 745                 750         


Tyr Lys Asp Phe Ala Val Trp Gln Ser Glu Leu Phe Gln Ser Asp Val 
        755                 760                 765             


Tyr Thr Glu His Glu Asn Tyr Trp Leu Asn Ala Phe Ser Gly Asp Ile 
    770                 775                 780                 


Pro Val Leu Asn Leu Pro Ala Asp Phe Ser Arg Pro Leu Thr Gln Ser 
785                 790                 795                 800 


Phe Glu Gly Asp Cys Val Ser Phe Gln Ala Asp Lys Ala Leu Leu Asp 
                805                 810                 815     


Asp Leu His Lys Leu Ala Gln Glu Ser Gln Ser Thr Leu Phe Met Val 
            820                 825                 830         


Leu Leu Ala Ala Tyr Asn Val Leu Leu Ala Lys Tyr Ser Gly Gln Glu 
        835                 840                 845             


Asp Ile Val Val Gly Thr Pro Ile Ala Gly Arg Ser His Ala Asp Ile 
    850                 855                 860                 


Glu Asn Val Leu Gly Met Phe Val Asn Thr Leu Ala Leu Arg Asn Tyr 
865                 870                 875                 880 


Pro Val Glu Thr Lys His Phe Gln Ala Phe Leu Glu Glu Val Lys Gln 
                885                 890                 895     


Asn Thr Leu Gln Ala Tyr Ala His Gln Asp Tyr Pro Phe Glu Ala Leu 
            900                 905                 910         


Val Glu Lys Leu Asp Ile Gln Arg Asp Leu Ser Arg Asn Pro Leu Phe 
        915                 920                 925             


Asp Thr Met Phe Ile Leu Gln Asn Leu Asp Gln Lys Ala Tyr Glu Leu 
    930                 935                 940                 


Asp Gly Leu Lys Leu Glu Ala Tyr Pro Ala Gln Ala Gly Asn Ala Lys 
945                 950                 955                 960 


Phe Asp Leu Thr Leu Glu Ala His Glu Asp Glu Thr Gly Ile His Phe 
                965                 970                 975     


Ala Leu Val Tyr Ser Thr Lys Leu Phe Gln Arg Glu Ser Ile Glu Arg 
            980                 985                 990         


Met Ala Gly His Phe Leu Gln Val  Leu Arg Gln Val Val  Ala Asp Gln 
        995                 1000                 1005             


Ala Thr  Ala Leu Arg Glu Ile  Ser Leu Leu Ser Glu  Glu Glu Arg 
    1010                 1015                 1020             


Arg Ile  Val Thr Val Asp Phe  Asn Asn Thr Phe Ala  Tyr Pro Arg 
    1025                 1030                 1035             


Asp Leu  Thr Ile Gln Glu Leu  Phe Glu Gln Gln Ala  Ala Lys Thr 
    1040                 1045                 1050             


Pro Glu  His Ala Ala Val Val  Met Asp Gly Gln Met  Leu Thr Tyr 
    1055                 1060                 1065             


Arg Glu  Leu Asn Glu Lys Ala  Asn Gln Leu Ala His  Val Leu Arg 
    1070                 1075                 1080             


Gln Asn  Gly Val Gly Lys Glu  Ser Ile Val Gly Leu  Leu Ala Asp 
    1085                 1090                 1095             


Arg Ser  Leu Glu Met Ile Thr  Gly Ile Met Gly Ile  Leu Lys Ala 
    1100                 1105                 1110             


Gly Gly  Ala Tyr Leu Gly Leu  Asp Pro Glu His Pro  Ser Glu Arg 
    1115                 1120                 1125             


Leu Ala  Tyr Met Leu Glu Asp  Gly Gly Val Lys Val  Val Leu Val 
    1130                 1135                 1140             


Gln Lys  His Leu Leu Pro Leu  Val Gly Glu Gly Leu  Met Pro Ile 
    1145                 1150                 1155             


Val Leu  Glu Glu Glu Ser Leu  Arg Pro Glu Asp Cys  Gly Asn Pro 
    1160                 1165                 1170             


Ala Ile  Val Asn Gly Ala Ser  Asp Leu Ala Tyr Val  Met Tyr Thr 
    1175                 1180                 1185             


Ser Gly  Ser Thr Gly Lys Pro  Lys Gly Val Met Val  Glu His Arg 
    1190                 1195                 1200             


Asn Val  Thr Arg Leu Val Met  His Thr Asn Tyr Val  Gln Val Arg 
    1205                 1210                 1215             


Glu Ser  Asp Arg Met Ile Gln  Thr Gly Ala Ile Gly  Phe Asp Ala 
    1220                 1225                 1230             


Met Thr  Phe Glu Ile Phe Gly  Ala Leu Leu His Gly  Ala Ser Leu 
    1235                 1240                 1245             


Tyr Leu  Val Ser Lys Asp Val  Leu Leu Asp Ala Glu  Lys Leu Gly 
    1250                 1255                 1260             


Asp Phe  Leu Arg Thr Asn Gln  Ile Thr Thr Met Trp  Leu Thr Ser 
    1265                 1270                 1275             


Pro Leu  Phe Asn Gln Leu Ser  Gln Asp Asn Pro Ala  Met Phe Asp 
    1280                 1285                 1290             


Ser Leu  Arg Ala Leu Ile Val  Gly Gly Glu Ala Leu  Ser Pro Lys 
    1295                 1300                 1305             


His Ile  Asn Arg Val Lys Ser  Ala Leu Pro Asp Leu  Glu Ile Trp 
    1310                 1315                 1320             


Asn Gly  Tyr Gly Pro Thr Glu  Asn Thr Thr Phe Ser  Thr Cys Tyr 
    1325                 1330                 1335             


Leu Ile  Glu Gln His Phe Glu  Glu Gln Ile Pro Ile  Gly Lys Pro 
    1340                 1345                 1350             


Ile Ala  Asn Ser Thr Ala Tyr  Ile Val Asp Gly Asn  Asn Gln Pro 
    1355                 1360                 1365             


Gln Pro  Ile Gly Val Pro Gly  Glu Leu Cys Val Gly  Gly Asp Gly 
    1370                 1375                 1380             


Val Ala  Arg Gly Tyr Val Asn  Lys Pro Glu Leu Thr  Ala Glu Lys 
    1385                 1390                 1395             


Phe Val  Pro Asn Pro Phe Ala  Pro Gly Glu Thr Met  Tyr Arg Thr 
    1400                 1405                 1410             


Gly Asp  Leu Ala Arg Trp Leu  Pro Asp Gly Thr Ile  Glu Tyr Leu 
    1415                 1420                 1425             


Gly Arg  Ile Asp Gln Gln Val  Lys Ile Arg Gly Tyr  Arg Ile Glu 
    1430                 1435                 1440             


Leu Gly  Glu Ile Glu Thr Val  Leu Ser Gln Gln Ala  Gln Val Lys 
    1445                 1450                 1455             


Glu Ala  Val Val Ala Val Ile  Glu Glu Ala Asn Gly  Gln Lys Ala 
    1460                 1465                 1470             


Leu Cys  Ala Tyr Phe Val Pro  Glu Gln Ala Val Asp  Ala Ala Glu 
    1475                 1480                 1485             


Leu Arg  Glu Ala Met Ser Lys  Gln Leu Pro Gly Tyr  Met Val Pro 
    1490                 1495                 1500             


Ala Tyr  Tyr Val Gln Met Glu  Lys Leu Pro Leu Thr  Ala Asn Gly 
    1505                 1510                 1515             


Lys Val  Asp Arg Arg Ala Leu  Pro Gln Pro Ser Gly  Glu Arg Thr 
    1520                 1525                 1530             


Thr Gly  Ser Ala Phe Val Ala  Ala Gln Asn Asp Thr  Glu Ala Lys 
    1535                 1540                 1545             


Leu Gln  Gln Ile Trp Gln Glu  Val Leu Gly Ile Pro  Ala Ile Gly 
    1550                 1555                 1560             


Ile His  Asp Asn Phe Phe Glu  Ile Gly Gly His Ser  Leu Lys Ala 
    1565                 1570                 1575             


Met Asn  Val Ile Thr Gln Val  His Lys Thr Phe Gln  Val Glu Leu 
    1580                 1585                 1590             


Pro Leu  Lys Ala Leu Phe Ala  Thr Pro Thr Ile His  Glu Leu Ala 
    1595                 1600                 1605             


Ala His  Ile Ser Glu Lys Thr  Glu Tyr Thr Ala Ile  Gln Pro Val 
    1610                 1615                 1620             


Ala Ala  Gln Glu Phe Tyr Pro  Val Ser Ser Ala Gln  Lys Arg Met 
    1625                 1630                 1635             


Tyr Ile  Leu Gln Gln Phe Glu  Gly Asn Gly Ile Ser  Tyr Asn Ile 
    1640                 1645                 1650             


Ser Gly  Ala Ile Leu Leu Glu  Gly Lys Leu Asp Tyr  Ala Arg Phe 
    1655                 1660                 1665             


Ala Ser  Ala Val Gln Gln Leu  Ala Glu Arg His Glu  Ala Leu Arg 
    1670                 1675                 1680             


Thr Ser  Phe His Arg Ile Asp  Gly Glu Pro Val Gln  Lys Val His 
    1685                 1690                 1695             


Glu Glu  Val Glu Val Pro Leu  Phe Met Leu Glu Ala  Pro Glu Asp 
    1700                 1705                 1710             


Gln Ala  Glu Lys Ile Met Arg  Glu Phe Val Arg Pro  Phe Asp Leu 
    1715                 1720                 1725             


Gly Val  Ala Pro Leu Met Arg  Thr Gly Leu Leu Lys  Leu Gly Lys 
    1730                 1735                 1740             


Asp Arg  His Leu Phe Leu Leu  Asp Met His His Ile  Ile Ser Asp 
    1745                 1750                 1755             


Gly Val  Ser Ser Gln Ile Leu  Leu Arg Glu Phe Ala  Glu Leu Tyr 
    1760                 1765                 1770             


Gln Gly  Ala Asp Leu Gln Pro  Leu Ser Leu Gln Tyr  Lys Asp Phe 
    1775                 1780                 1785             


Ala Ala  Trp Gln Asn Glu Leu  Phe Gln Thr Glu Ala  Tyr Lys Lys 
    1790                 1795                 1800             


Gln Glu  Gln His Trp Leu Asn  Thr Phe Ala Asp Glu  Ile Pro Leu 
    1805                 1810                 1815             


Leu Asn  Leu Pro Thr Asp Tyr  Pro Arg Pro Ser Val  Gln Ser Phe 
    1820                 1825                 1830             


Ala Gly  Asp Leu Val Leu Phe  Ala Ala Gly Lys Glu  Leu Leu Glu 
    1835                 1840                 1845             


Arg Leu  Gln Gln Val Ala Ser  Glu Thr Gly Thr Thr  Leu Tyr Met 
    1850                 1855                 1860             


Ile Leu  Leu Ala Ala Tyr Asn  Val Leu Leu Ser Lys  Tyr Thr Gly 
    1865                 1870                 1875             


Gln Glu  Asp Ile Ile Val Gly  Thr Pro Val Ala Gly  Arg Ser His 
    1880                 1885                 1890             


Ala Asp  Val Glu Asn Ile Met  Gly Ile Phe Val Asn  Thr Leu Ala 
    1895                 1900                 1905             


Leu Arg  Asn Gln Pro Ala Ser  Ser Lys Thr Met Leu  Glu Asn Asn 
    1910                 1915                 1920             


Ile Thr  Gln Cys Asp Ser Ile  Asn Asp Val Tyr Leu  Lys Glu Glu 
    1925                 1930                 1935             


Ala Ile  Thr Leu Met Asp Met  Leu Glu Ser Gln Leu  Lys His Gln 
    1940                 1945                 1950             


Ala Asp  Gly Tyr Val Val Ile  Asp Gln Glu Glu Ser  Leu Ser Tyr 
    1955                 1960                 1965             


Ala Asp  Phe Tyr Leu Arg Val  Lys Glu Ile Gly Tyr  Cys Leu Ser 
    1970                 1975                 1980             


Glu Ile  Ser Ser Lys Asn Ser  Val Gly Ile Gly Leu  Phe Cys Asp 
    1985                 1990                 1995             


Pro Ser  Ile Asp Leu Ile Cys  Gly Ala Trp Gly Ile  Leu Ser Ala 
    2000                 2005                 2010             


Asp Lys  Ala Tyr Leu Pro Leu  Ser Pro Asp Tyr Pro  Thr Glu Arg 
    2015                 2020                 2025             


Leu Lys  Tyr Met Ile Glu Asp  Ser Gly Ile Asp Val  Ile Phe Thr 
    2030                 2035                 2040             


Gln Ser  His Leu Lys Ala Gln  Leu Gln Asp Ile Ala  Pro Lys Ser 
    2045                 2050                 2055             


Val Leu  Ile Met Thr Pro Glu  Asp Val Ala Leu Thr  Ile Lys Thr 
    2060                 2065                 2070             


Arg Thr  Ile Glu Asp Ile Leu  Gly Thr Val Gln Val  Pro Lys Pro 
    2075                 2080                 2085             


Thr Ser  Leu Ala Tyr Ile Ile  Tyr Thr Ser Gly Ser  Thr Gly Lys 
    2090                 2095                 2100             


Pro Lys  Gly Val Met Ile Glu  His His Ser Ile Val  Asn Gln Met 
    2105                 2110                 2115             


Arg Phe  Leu Ala Lys Ala Phe  Lys Leu Gly Cys His  Ser Arg Ile 
    2120                 2125                 2130             


Leu Gln  Lys Thr Pro Met Ser  Phe Asp Ala Ala Gln  Trp Glu Ile 
    2135                 2140                 2145             


Leu Ala  Pro Ala Ile Gly Gly  Gln Val Ile Met Gly  Pro Leu Gly 
    2150                 2155                 2160             


Cys Tyr  Arg Asp Pro Asp Ala  Ile Ile Lys Thr Ile  Leu Gln His 
    2165                 2170                 2175             


Gln Val  Thr Thr Leu Gln Cys  Val Pro Thr Leu Leu  Gln Ala Leu 
    2180                 2185                 2190             


Leu Asp  Asn Pro Asn Phe Leu  Asp Cys Leu Ser Leu  Thr Gln Val 
    2195                 2200                 2205             


Phe Ser  Gly Gly Glu Ala Leu  Thr Thr Lys Leu Ala  Thr Gln Phe 
    2210                 2215                 2220             


Leu Asn  Ser Phe Thr His Cys  Glu Leu Ile Asn Leu  Tyr Gly Pro 
    2225                 2230                 2235             


Thr Glu  Cys Thr Ile Asn Ser  Ser Phe Phe Arg Val  Thr Asn Glu 
    2240                 2245                 2250             


Thr Leu  Pro Asn Tyr Gln Thr  Ser Ile Ser Ile Gly  Ala Pro Val 
    2255                 2260                 2265             


Asp Asn  Thr Glu Tyr Tyr Val  Leu Asp Asp Asp Arg  Leu Pro Val 
    2270                 2275                 2280             


Ala Val  Gly Glu Ile Gly Glu  Leu Tyr Ile Ser Gly  Ala Gln Leu 
    2285                 2290                 2295             


Ala Arg  Gly Tyr Leu His Lys  Pro Glu Met Thr Lys  Asp Lys Phe 
    2300                 2305                 2310             


Ile Cys  Asn His Leu Val Ser  Gly Thr Gln His Gln  Trp Leu Tyr 
    2315                 2320                 2325             


Arg Thr  Gly Asp Leu Val Thr  Arg Gly Ala Asp Gly  Asn Thr Tyr 
    2330                 2335                 2340             


Phe Val  Gly Arg Val Asp Ser  Gln Val Lys Leu Arg  Gly Tyr Arg 
    2345                 2350                 2355             


Ile Glu  Leu Asp Glu Ile Arg  His Ala Ile Glu Glu  His Ser Trp 
    2360                 2365                 2370             


Ile Lys  Thr Ala Ala Met Leu  Ile Lys Lys Asp Ala  Arg Thr Gly 
    2375                 2380                 2385             


Phe Gln  Asn Leu Ile Ala Cys  Val Glu Leu Asp Glu  Lys Glu Ala 
    2390                 2395                 2400             


Ala Leu  Met Asp Gln Gly Asn  Ser Ser Ser His His  Lys Ser Lys 
    2405                 2410                 2415             


Ala Asp  Lys Leu Gln Val Lys  Ala Gln Leu Ser Asn  Ser Gly Cys 
    2420                 2425                 2430             


Arg Ser  Glu Glu Leu Cys Glu  Asn Arg Pro Thr Phe  Leu Leu Pro 
    2435                 2440                 2445             


Tyr Gln  Glu Gly Glu Ile Lys  Gln Arg Glu Tyr Ala  Phe Gly Arg 
    2450                 2455                 2460             


Lys Thr  Tyr Arg Tyr Phe Glu  Gly Thr Glu Ile Thr  Val Glu Lys 
    2465                 2470                 2475             


Leu Lys  Lys Leu Leu Thr Ala  Thr Gln Ser Asn Glu  Ile Ser Ser 
    2480                 2485                 2490             


Leu Pro  Leu Ser His Leu Thr  Leu Asn Asp Phe Gly  Tyr Ala Leu 
    2495                 2500                 2505             


Arg Tyr  Phe Gly Gln Phe Thr  Ser His Gln Arg Leu  Leu Pro Lys 
    2510                 2515                 2520             


Tyr Ala  Tyr Ala Ser Pro Gly  Ala Leu Tyr Ala Thr  Gln Met Tyr 
    2525                 2530                 2535             


Phe Glu  Leu His Asn Val Leu  Gly Leu Asp Ala Gly  Ile Tyr Tyr 
    2540                 2545                 2550             


Tyr His  Pro Val Thr His Lys  Leu Ile Lys Ile Ser  Thr Leu Ser 
    2555                 2560                 2565             


Arg Arg  Gln Met Pro Thr Ile  Lys Val His Phe Ile  Gly Lys His 
    2570                 2575                 2580             


Glu Ala  Ile Glu Pro Val Tyr  Lys Asn Asn Ile Gln  Glu Val Leu 
    2585                 2590                 2595             


Glu Met  Glu Ala Gly His Met  Met Gly Leu Phe Asp  Asp Val Leu 
    2600                 2605                 2610             


Pro Glu  Ile Gly Leu Ser Ile  Gly Lys Ser Glu Tyr  Gln Asp Glu 
    2615                 2620                 2625             


Cys Pro  Asp Trp Tyr Asp Gly  Asp Ile Gln Asp Tyr  Tyr Leu Gly 
    2630                 2635                 2640             


Ala Phe  Glu Ile Cys Ser Tyr  Glu His Gly Leu Pro  Pro Phe Glu 
    2645                 2650                 2655             


Thr Asp  Ile Tyr Leu Gln Thr  His Ala His Lys Ile  Pro Glu Met 
    2660                 2665                 2670             


Pro Cys  Gly Leu Tyr His Phe  Ser Asn Gly Glu Phe  Val Arg Ile 
    2675                 2680                 2685             


Ser Asp  Asp Ile Val Arg Lys  Lys Asp Val Ile Ala  Ile Asn Gln 
    2690                 2695                 2700             


Gln Val  Tyr Asp Arg Ser Ser  Phe Gly Val Ser Ile  Ile Pro Arg 
    2705                 2710                 2715             


Cys Val  Pro Glu Trp His Tyr  Tyr Ile Thr Leu Gly  Arg Arg Leu 
    2720                 2725                 2730             


His Ala  Leu Gln Ser Asn Pro  Leu Tyr Ile Gly Leu  Met Ser Ser 
    2735                 2740                 2745             


Gly Tyr  Ser Ser Lys Ser Asn  Asn Asp Leu Pro Ser  Ala Lys Arg 
    2750                 2755                 2760             


Met Arg  Ser Ile Leu Asn Ala  Leu Asp Arg Pro Met  Ala Ala Phe 
    2765                 2770                 2775             


Tyr Phe  Cys Ile Gly Gly Gly  Ile Ser Gln Ala Gln  Tyr Met Cys 
    2780                 2785                 2790             


Glu Gly  Met Lys Glu Asp Val  Val His Met Lys Gly  Pro Val Glu 
    2795                 2800                 2805             


Ile Ile  Lys Asp Asp Leu Gln  Gln Gln Leu Pro Gln  Tyr Met Ile 
    2810                 2815                 2820             


Pro Asn  Lys Val Leu Val Phe  Asp Lys Leu Pro Leu  Thr Ala Asn 
    2825                 2830                 2835             


Gly Lys  Val Asp Tyr Gln Ser  Leu Ser Glu Ser Lys  Ala Val Glu 
    2840                 2845                 2850             


Asn Val  Ser Thr Gln Arg Leu  Leu Val Pro Leu His  Thr Asp Thr 
    2855                 2860                 2865             


Glu Ile  Arg Leu Gly Lys Ile  Trp Met Glu Val Leu  Lys Trp Asp 
    2870                 2875                 2880             


Ser Val  Ser Ala Leu Asp Asp  Phe Phe Glu Ser Gly  Gly Asn Ser 
    2885                 2890                 2895             


Leu Met  Ala Val Ala Met Val  Asn Lys Ile Asn Ala  Ala Phe Asn 
    2900                 2905                 2910             


Ile Arg  Phe Pro Leu Gln Ile  Leu Phe Gln Ser Pro  Asn Ile Ala 
    2915                 2920                 2925             


Glu Leu  Ala Lys Trp Ile Glu  Gln Thr Asp Ser Lys  Thr Ile Ser 
    2930                 2935                 2940             


Arg Leu  Ile Leu Leu Asn Gln  Ala Ser Lys Asp Pro  Ile Tyr Cys 
    2945                 2950                 2955             


Trp Pro  Gly Leu Gly Gly Tyr  Pro Met Ser Leu Arg  Leu Leu Ala 
    2960                 2965                 2970             


Asn Lys  Val Val Pro Asp Arg  Ala Phe Tyr Gly Ile  Gln Ala Tyr 
    2975                 2980                 2985             


Gly Ile  Asn Glu Ser Glu Ile  Pro Phe Ser Ser Ile  Gln Arg Met 
    2990                 2995                 3000             


Ala Glu  Glu Asp Ile Lys Glu  Ile Lys Lys Ile Gln  Pro Glu Gly 
    3005                 3010                 3015             


Pro Tyr  Ile Leu Trp Gly Tyr  Ser Phe Gly Ala Arg  Val Ala Phe 
    3020                 3025                 3030             


Glu Val  Ala Tyr Gln Leu Glu  Gln Ala Gly Glu Glu  Val Asn Ala 
    3035                 3040                 3045             


Leu Asn  Leu Leu Ala Pro Gly  Ser Pro His Leu Asp  Met Lys Gln 
    3050                 3055                 3060             


Ala Glu  Tyr Met Asp Lys Gly  Ala Glu Phe Thr Asn  Pro Ala Phe 
    3065                 3070                 3075             


Val Lys  Ile Leu Phe Ser Val  Phe Ser Arg Ser Ile  Asn Ser Pro 
    3080                 3085                 3090             


Met Val  Lys Thr Cys Leu Glu  Gln Val Asn Ser Glu  Thr Thr Phe 
    3095                 3100                 3105             


Ile Asn  Phe Ile Cys Ser Arg  Phe Lys Asn Leu Glu  Pro Ser Leu 
    3110                 3115                 3120             


Val Lys  Arg Ile Val Arg Ile  Val Thr Leu Thr Tyr  Asp Phe Lys 
    3125                 3130                 3135             


Tyr Ser  Ile Asp Glu Leu Tyr  His Arg His Leu Lys  Ala Pro Ile 
    3140                 3145                 3150             


Thr Ile  Phe Lys Ala Asn Arg  Asp Asn Asp Ser Phe  Ile Glu Glu 
    3155                 3160                 3165             


Ser Asp  Val Ile Ser Ser Met  Ser Pro Lys Ile Ile  Glu Leu Ile 
    3170                 3175                 3180             


Ser Asp  His Tyr Gln Leu Leu  Glu Ser Glu Gly Val  Ala Glu Ile 
    3185                 3190                 3195             


Glu Lys  Ile Ile 
    3200         


<210>  37
<211>  1591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minimal construct C(of TycC2)-Ind

<400>  37

Ser Glu Lys Thr Glu Tyr Thr Ala Ile Gln Pro Val Ala Ala Gln Glu 
1               5                   10                  15      


Phe Tyr Pro Val Ser Ser Ala Gln Lys Arg Met Tyr Ile Leu Gln Gln 
            20                  25                  30          


Phe Glu Gly Asn Gly Ile Ser Tyr Asn Ile Ser Gly Ala Ile Leu Leu 
        35                  40                  45              


Glu Gly Lys Leu Asp Tyr Ala Arg Phe Ala Ser Ala Val Gln Gln Leu 
    50                  55                  60                  


Ala Glu Arg His Glu Ala Leu Arg Thr Ser Phe His Arg Ile Asp Gly 
65                  70                  75                  80  


Glu Pro Val Gln Lys Val His Glu Glu Val Glu Val Pro Leu Phe Met 
                85                  90                  95      


Leu Glu Ala Pro Glu Asp Gln Ala Glu Lys Ile Met Arg Glu Phe Val 
            100                 105                 110         


Arg Pro Phe Asp Leu Gly Val Ala Pro Leu Met Arg Thr Gly Leu Leu 
        115                 120                 125             


Lys Leu Gly Lys Asp Arg His Leu Phe Leu Leu Asp Met His His Ile 
    130                 135                 140                 


Ile Ser Asp Gly Val Ser Ser Gln Ile Leu Leu Arg Glu Phe Ala Glu 
145                 150                 155                 160 


Leu Tyr Gln Gly Ala Asp Leu Gln Pro Leu Ser Leu Gln Tyr Lys Asp 
                165                 170                 175     


Phe Ala Ala Trp Gln Asn Glu Leu Phe Gln Thr Glu Ala Tyr Lys Lys 
            180                 185                 190         


Gln Glu Gln His Trp Leu Asn Thr Phe Ala Asp Glu Ile Pro Leu Leu 
        195                 200                 205             


Asn Leu Pro Thr Asp Tyr Pro Arg Pro Ser Val Gln Ser Phe Ala Gly 
    210                 215                 220                 


Asp Leu Val Leu Phe Ala Ala Gly Lys Glu Leu Leu Glu Arg Leu Gln 
225                 230                 235                 240 


Gln Val Ala Ser Glu Thr Gly Thr Thr Leu Tyr Met Ile Leu Leu Ala 
                245                 250                 255     


Ala Tyr Asn Val Leu Leu Ser Lys Tyr Thr Gly Gln Glu Asp Ile Ile 
            260                 265                 270         


Val Gly Thr Pro Val Ala Gly Arg Ser His Ala Asp Val Glu Asn Ile 
        275                 280                 285             


Met Gly Ile Phe Val Asn Thr Leu Ala Leu Arg Asn Gln Pro Ala Ser 
    290                 295                 300                 


Ser Lys Thr Met Leu Glu Asn Asn Ile Thr Gln Cys Asp Ser Ile Asn 
305                 310                 315                 320 


Asp Val Tyr Leu Lys Glu Glu Ala Ile Thr Leu Met Asp Met Leu Glu 
                325                 330                 335     


Ser Gln Leu Lys His Gln Ala Asp Gly Tyr Val Val Ile Asp Gln Glu 
            340                 345                 350         


Glu Ser Leu Ser Tyr Ala Asp Phe Tyr Leu Arg Val Lys Glu Ile Gly 
        355                 360                 365             


Tyr Cys Leu Ser Glu Ile Ser Ser Lys Ser Ser Val Gly Ile Gly Leu 
    370                 375                 380                 


Phe Cys Asp Pro Ser Ile Asp Leu Ile Cys Gly Ala Trp Gly Ile Leu 
385                 390                 395                 400 


Ser Ala Asp Lys Ala Tyr Leu Pro Leu Ser Pro Asp Tyr Pro Thr Glu 
                405                 410                 415     


Arg Leu Lys Tyr Met Ile Glu Asp Ser Gly Ile Asp Val Ile Phe Thr 
            420                 425                 430         


Gln Ser His Leu Lys Ala Gln Leu Gln Asp Ile Ala Pro Lys Ser Val 
        435                 440                 445             


Leu Ile Met Thr Pro Glu Asp Val Ala Leu Thr Ile Lys Thr Arg Thr 
    450                 455                 460                 


Ile Glu Asp Ile Leu Gly Thr Val Gln Val Pro Lys Pro Thr Ser Leu 
465                 470                 475                 480 


Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly Val 
                485                 490                 495     


Met Ile Glu His His Ser Ile Val Asn Gln Met Arg Phe Leu Ala Lys 
            500                 505                 510         


Ala Phe Lys Leu Gly Cys His Ser Arg Ile Leu Gln Lys Thr Pro Met 
        515                 520                 525             


Ser Phe Asp Ala Ala Gln Trp Glu Ile Leu Ala Pro Ala Ile Gly Gly 
    530                 535                 540                 


Gln Val Ile Met Gly Pro Leu Gly Cys Tyr Arg Asp Pro Asp Ala Ile 
545                 550                 555                 560 


Ile Lys Thr Ile Leu Gln His Gln Val Thr Thr Leu Gln Cys Val Pro 
                565                 570                 575     


Thr Leu Leu Gln Ala Leu Leu Asp Asn Pro Asn Phe Leu Asp Cys Leu 
            580                 585                 590         


Ser Leu Thr Gln Val Phe Ser Gly Gly Glu Ala Leu Thr Thr Lys Leu 
        595                 600                 605             


Ala Thr Gln Phe Leu Asn Ser Phe Thr His Cys Glu Leu Ile Asn Leu 
    610                 615                 620                 


Tyr Gly Pro Thr Glu Cys Thr Ile Asn Ser Ser Phe Phe Arg Val Thr 
625                 630                 635                 640 


Asn Glu Thr Leu Pro Asn Tyr Gln Thr Ser Ile Ser Ile Gly Ala Pro 
                645                 650                 655     


Val Asp Asn Thr Glu Tyr Tyr Val Leu Asp Asp Asp Arg Leu Pro Val 
            660                 665                 670         


Ala Val Gly Glu Ile Gly Glu Leu Tyr Ile Ser Gly Ala Gln Leu Ala 
        675                 680                 685             


Arg Gly Tyr Leu His Lys Pro Glu Met Thr Lys Asp Lys Phe Ile Cys 
    690                 695                 700                 


Asn His Leu Val Ser Gly Thr Gln His Gln Trp Leu Tyr Arg Thr Gly 
705                 710                 715                 720 


Asp Leu Val Thr Arg Gly Ala Asp Gly Asn Thr Tyr Phe Val Gly Arg 
                725                 730                 735     


Val Asp Ser Gln Val Lys Leu Arg Gly Tyr Arg Ile Glu Leu Asp Glu 
            740                 745                 750         


Ile Arg His Ala Ile Glu Glu His Ser Trp Ile Lys Thr Ala Ala Met 
        755                 760                 765             


Leu Ile Lys Lys Asp Ala Arg Thr Gly Phe Gln Asn Leu Ile Ala Cys 
    770                 775                 780                 


Val Glu Leu Asp Glu Lys Glu Ala Ala Leu Met Asp Gln Gly Asn Ser 
785                 790                 795                 800 


Ser Ser His His Lys Ser Lys Ala Asp Lys Leu Gln Val Lys Ala Gln 
                805                 810                 815     


Leu Ser Asn Ser Gly Cys Arg Ser Glu Glu Leu Cys Glu Asn Arg Pro 
            820                 825                 830         


Thr Phe Leu Leu Pro Tyr Gln Glu Gly Glu Ile Lys Gln Arg Glu Tyr 
        835                 840                 845             


Ala Phe Gly Arg Lys Thr Tyr Arg Tyr Phe Glu Gly Thr Glu Ile Thr 
    850                 855                 860                 


Val Glu Lys Leu Lys Lys Leu Leu Thr Ala Thr Gln Ser Asn Glu Ile 
865                 870                 875                 880 


Ser Ser Leu Pro Leu Ser His Leu Thr Leu Asn Asp Phe Gly Tyr Ala 
                885                 890                 895     


Leu Arg Tyr Phe Gly Gln Phe Thr Ser His Gln Arg Leu Leu Pro Lys 
            900                 905                 910         


Tyr Ala Tyr Ala Ser Pro Gly Ala Leu Tyr Ala Thr Gln Met Tyr Phe 
        915                 920                 925             


Glu Leu His Asn Val Leu Gly Leu Asp Ala Gly Ile Tyr Tyr Tyr His 
    930                 935                 940                 


Pro Val Thr His Lys Leu Ile Lys Ile Ser Thr Leu Ser Arg Arg Gln 
945                 950                 955                 960 


Met Pro Thr Ile Lys Val His Phe Ile Gly Lys His Glu Ala Ile Glu 
                965                 970                 975     


Pro Val Tyr Lys Asn Asn Ile Gln Glu Val Leu Glu Met Glu Ala Gly 
            980                 985                 990         


His Met Met Gly Leu Phe Asp Asp  Val Leu Pro Glu Ile  Gly Leu Ser 
        995                 1000                 1005             


Ile Gly  Lys Ser Glu Tyr Gln  Asp Glu Cys Pro Asp  Trp Tyr Asp 
    1010                 1015                 1020             


Gly Asp  Ile Gln Asp Tyr Tyr  Leu Gly Ala Phe Glu  Ile Cys Ser 
    1025                 1030                 1035             


Tyr Glu  His Gly Leu Pro Pro  Phe Glu Thr Asp Ile  Tyr Leu Gln 
    1040                 1045                 1050             


Thr His  Ala His Lys Ile Pro  Glu Met Pro Cys Gly  Leu Tyr His 
    1055                 1060                 1065             


Phe Ser  Asn Gly Glu Phe Val  Arg Ile Ser Asp Asp  Ile Val Arg 
    1070                 1075                 1080             


Lys Lys  Asp Val Ile Ala Ile  Asn Gln Gln Val Tyr  Asp Arg Ser 
    1085                 1090                 1095             


Ser Phe  Gly Val Ser Ile Ile  Pro Arg Cys Val Pro  Glu Trp His 
    1100                 1105                 1110             


Tyr Tyr  Ile Thr Leu Gly Arg  Arg Leu His Ala Leu  Gln Ser Asn 
    1115                 1120                 1125             


Pro Leu  Tyr Ile Gly Leu Met  Ser Ser Gly Tyr Ser  Ser Lys Ser 
    1130                 1135                 1140             


Asn Asn  Asp Leu Pro Ser Ala  Lys Arg Met Arg Ser  Ile Leu Asn 
    1145                 1150                 1155             


Ala Leu  Asp Arg Pro Met Ala  Ala Phe Tyr Phe Cys  Ile Gly Gly 
    1160                 1165                 1170             


Gly Ile  Ser Gln Ala Gln Tyr  Met Cys Glu Gly Met  Lys Glu Asp 
    1175                 1180                 1185             


Val Val  His Met Lys Gly Pro  Val Glu Ile Ile Lys  Asp Asp Leu 
    1190                 1195                 1200             


Gln Gln  Gln Leu Pro Gln Tyr  Met Ile Pro Asn Lys  Val Leu Val 
    1205                 1210                 1215             


Phe Asp  Lys Leu Pro Leu Thr  Ala Asn Gly Lys Val  Asp Tyr Gln 
    1220                 1225                 1230             


Ser Leu  Ser Glu Ser Lys Ala  Val Glu Asn Val Ser  Thr Gln Arg 
    1235                 1240                 1245             


Leu Leu  Val Pro Leu His Thr  Asp Thr Glu Ile Arg  Leu Gly Lys 
    1250                 1255                 1260             


Ile Trp  Met Glu Val Leu Lys  Trp Asp Ser Val Ser  Ala Leu Asp 
    1265                 1270                 1275             


Asp Phe  Phe Glu Ser Gly Gly  Asn Ser Leu Met Ala  Val Ala Met 
    1280                 1285                 1290             


Val Asn  Lys Ile Asn Ala Ala  Phe Asn Ile Arg Phe  Pro Leu Gln 
    1295                 1300                 1305             


Ile Leu  Phe Gln Ser Pro Asn  Ile Ala Glu Leu Ala  Lys Trp Ile 
    1310                 1315                 1320             


Glu Gln  Thr Asp Ser Lys Thr  Ile Ser Arg Leu Ile  Leu Leu Asn 
    1325                 1330                 1335             


Gln Ala  Ser Lys Asp Pro Ile  Tyr Cys Trp Pro Gly  Leu Gly Gly 
    1340                 1345                 1350             


Tyr Pro  Met Ser Leu Arg Leu  Leu Ala Asn Lys Val  Val Pro Asp 
    1355                 1360                 1365             


Arg Ala  Phe Tyr Gly Ile Gln  Ala Tyr Gly Ile Asn  Glu Ser Glu 
    1370                 1375                 1380             


Ile Pro  Phe Ser Ser Ile Gln  Arg Met Ala Glu Glu  Asp Ile Lys 
    1385                 1390                 1395             


Glu Ile  Lys Lys Ile Gln Pro  Glu Gly Pro Tyr Ile  Leu Trp Gly 
    1400                 1405                 1410             


Tyr Ser  Phe Gly Ala Arg Val  Ala Phe Glu Val Ala  Tyr Gln Leu 
    1415                 1420                 1425             


Glu Gln  Ala Gly Glu Glu Val  Asn Ala Leu Asn Leu  Leu Ala Pro 
    1430                 1435                 1440             


Gly Ser  Pro His Leu Asp Met  Lys Gln Ala Glu Tyr  Met Asp Lys 
    1445                 1450                 1455             


Gly Ala  Glu Phe Thr Asn Pro  Ala Phe Val Lys Ile  Leu Phe Ser 
    1460                 1465                 1470             


Val Phe  Ser Arg Ser Ile Asn  Ser Pro Met Val Lys  Thr Cys Leu 
    1475                 1480                 1485             


Glu Gln  Val Asn Ser Glu Thr  Thr Phe Ile Asn Phe  Ile Cys Ser 
    1490                 1495                 1500             


Arg Phe  Lys Asn Leu Glu Pro  Ser Leu Val Lys Arg  Ile Val Arg 
    1505                 1510                 1515             


Ile Val  Thr Leu Thr Tyr Asp  Phe Lys Tyr Ser Ile  Asp Glu Leu 
    1520                 1525                 1530             


Tyr His  Arg His Leu Lys Ala  Pro Ile Thr Ile Phe  Lys Ala Asn 
    1535                 1540                 1545             


Arg Asp  Asn Asp Ser Phe Ile  Glu Glu Ser Asp Val  Ile Ser Ser 
    1550                 1555                 1560             


Met Ser  Pro Lys Ile Ile Glu  Leu Ile Ser Asp His  Tyr Gln Leu 
    1565                 1570                 1575             


Leu Glu  Ser Glu Gly Val Ala  Glu Ile Glu Lys Ile  Ile 
    1580                 1585                 1590     


<210>  38
<211>  1949
<212>  PRT
<213>  Shewanella violacea DSS12

<400>  38

Met Glu Pro Lys Ser Phe Asn Leu Ala Glu Gln Thr Ser Leu Val Ala 
1               5                   10                  15      


Val Leu Gln His Arg Ala Gln Ile Thr Pro Asn Lys Val Ala Tyr Ile 
            20                  25                  30          


Tyr Leu Glu Asn Gly Glu Asp Ile Glu Val Pro Ile Thr Tyr Ala Glu 
        35                  40                  45              


Leu Asp Cys Arg Ala Arg Glu Leu Ala Ala Gln Leu Gln Gly Lys Asn 
    50                  55                  60                  


Pro Leu Ile Gln Gln Glu Arg Val Leu Leu Ile Tyr Pro Gln Gly Ile 
65                  70                  75                  80  


Asp Phe Ile Val Ala Phe Phe Ala Thr Leu Tyr Ala Gly Ala Ile Ala 
                85                  90                  95      


Val Leu Val Tyr Pro Pro Ser Ser Lys Lys Met Ala Gln Arg Leu Asn 
            100                 105                 110         


Gly Ile Val Glu Asp Cys Asn Val Lys Leu Ile Leu Ser Thr Ala Lys 
        115                 120                 125             


Val Ile Ser Arg Met Asp Arg Met Asn Met Val Thr Asp Ala Gly Glu 
    130                 135                 140                 


Gln Asp Glu Asp Ala Ile Asn Ile Pro Ala Gln Tyr Trp Ile Asn Ser 
145                 150                 155                 160 


Asp Asn Leu Asp Pro Glu Ala Ala Arg Asp Phe Lys Gln Pro Ile Ile 
                165                 170                 175     


Leu Gly Glu His Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr Gly 
            180                 185                 190         


Thr Pro Lys Gly Val Met Ile Ser His Ser Asn Leu Met Ala Asn Gln 
        195                 200                 205             


Ala Ala Ile Lys Asp Ile Tyr Gln His Asp Asp Lys Thr Ile Phe Val 
    210                 215                 220                 


Gly Trp Leu Pro Leu Ile His Asp Met Gly Leu Ile Gly Asn Val Leu 
225                 230                 235                 240 


Gln Pro Met Tyr Leu Gly Ile Ser Leu Val Phe Met Ser Pro Leu His 
                245                 250                 255     


Phe Val Gln Lys Pro Val Arg Trp Leu Arg Ala Ile Ser Lys Tyr Gln 
            260                 265                 270         


Ala Thr Thr Ser Gly Gly Pro Asn Phe Ala Tyr Asp Leu Cys Val Arg 
        275                 280                 285             


Lys Ile Ala Asp Ala Asp Leu Ala Asp Leu Asp Leu Ser Ser Trp Thr 
    290                 295                 300                 


Leu Ala Tyr Asn Gly Ala Glu Pro Val Arg Lys Glu Thr Val Ser Arg 
305                 310                 315                 320 


Phe Asn Gln Arg Phe Ser Val Cys Gly Leu Lys Pro Glu Ser His Met 
                325                 330                 335     


Ala Val Tyr Gly Leu Ala Glu Ala Thr Leu Ile Val Thr Gly Thr Asn 
            340                 345                 350         


Lys Gln Ala Val Leu Ala Thr Ser Asp Asn Val Asp Tyr Met Ser Ser 
        355                 360                 365             


Gly Thr Cys Val Glu Val Asp Arg Val Arg Ile Val Asn Pro Glu Thr 
    370                 375                 380                 


Cys Val Glu Ala Asp Glu Gln Gln Glu Gly Glu Ile Trp Val His Gly 
385                 390                 395                 400 


Pro Ser Val Ala Lys Gly Tyr Trp Asn Arg Pro Glu Glu Thr Gln Thr 
                405                 410                 415     


Thr Phe Lys Ala Gln Ile Leu Gly Ser Glu Leu His Tyr Met Arg Thr 
            420                 425                 430         


Gly Asp Thr Gly Tyr Cys Lys Asn Gly Glu Ile His Val Thr Gly Arg 
        435                 440                 445             


Ile Lys Asp Ile Val Ile Val Gln Gly Lys Asn Phe His Pro Glu Asp 
    450                 455                 460                 


Ile Glu Trp Ser Leu Ile Asp Val Gln Gly Leu Arg Val Gly Gly Ser 
465                 470                 475                 480 


Val Ala Phe Ser Leu Asp Val Val Asp Glu Gln Gly Gln Thr Ser Glu 
                485                 490                 495     


Ser Leu Val Val Val Ala Gly Val Leu Glu Ser Asp Ser Asp Lys His 
            500                 505                 510         


Pro Ser Ile Ile Ser Asn Ile Arg Ser Phe Ile Tyr Gln Asp His Gln 
        515                 520                 525             


Leu Gln Val Asp Arg Val Val Leu Ile Lys Pro Lys Gln Ile Pro Met 
    530                 535                 540                 


Thr Thr Ser Gly Lys Val Gln Arg Arg Leu Thr Arg Gln Met Leu Val 
545                 550                 555                 560 


Ala Asn Glu Phe Thr Ile Leu Gly Asp Asp Leu Leu Ala Ala Val Asp 
                565                 570                 575     


Asp Lys Ser Thr Gln Ala Arg Ser Ser Ile Val Ala Ala Thr Thr Lys 
            580                 585                 590         


Ala Glu Leu Glu Leu Thr Ser Met Trp Gly Ala Ile Leu Gly Leu Ser 
        595                 600                 605             


Ala Ser Asp Ile Gly Ile Thr Asp Asn Phe Phe Asp Leu Gly Gly Ser 
    610                 615                 620                 


Ser Leu Thr Met Leu Glu Leu Ser Ile Gln Leu Asn Thr Thr Met Glu 
625                 630                 635                 640 


Leu Leu Phe Arg Tyr Pro Thr Ile Ser Ser Tyr Leu Tyr Arg Thr Ser 
                645                 650                 655     


Glu Tyr Glu Phe Pro Glu Val Glu Lys Asp Ile Tyr Leu Pro Ala Ala 
            660                 665                 670         


Asn Ile Asp Arg Ser Leu Glu Gly Glu Thr Gly Ile Ser Leu Ile Thr 
        675                 680                 685             


Gly Gly Thr Gly Phe Phe Gly Leu His Phe Leu Gln Ser Met Met Gln 
    690                 695                 700                 


Arg Thr Gln Asp Lys Phe Val Leu Leu Ile Arg Gly Glu Asn Asp Asp 
705                 710                 715                 720 


Val Met Asn Lys Lys Phe Thr Asp Ala Val Ala Tyr Phe His Met Glu 
                725                 730                 735     


Lys Asp Ile Asp Ile Gly Arg Val Ile Leu Ile Arg Gly Asp Leu Ser 
            740                 745                 750         


Glu His His Val Gly Ile Pro Asp Asp Lys Tyr Pro Trp Val Cys Gln 
        755                 760                 765             


Asn Val Asp Lys Ile Phe His Ile Gly Ser His Val Asn Asn Trp Leu 
    770                 775                 780                 


Pro Tyr Glu Gly Ile Arg Glu Ile Asn Val Asp Gly Thr Arg Ser Leu 
785                 790                 795                 800 


Leu Ala Leu Ala Arg Thr Gly Arg Lys Lys Glu Phe His Tyr Thr Ser 
                805                 810                 815     


Thr Ser Thr Phe Ser Pro Asp Lys Ala Asp Pro Ser Val Phe Leu Glu 
            820                 825                 830         


Gly Asp Thr Ile Asp Lys Asn Asp Ile Asn Arg Phe Phe Gly Tyr Asp 
        835                 840                 845             


Ile Ser Lys Tyr Ala Ser Glu Gln Met Cys Arg Ile Ala Arg Glu Glu 
    850                 855                 860                 


Gly Leu Ile Cys Asn Ile Tyr Arg Leu Val Trp Ile Gly Gly His Ile 
865                 870                 875                 880 


Glu Thr Gly Leu Thr Lys Leu Asn Asp Gly Phe Asn Ile Met Leu Arg 
                885                 890                 895     


Ile Leu Ile Thr Ile Lys Ala Phe Pro Lys Gly Asn Tyr Leu His Asp 
            900                 905                 910         


Ile Thr Pro Val Asp Leu Leu Ala Asp Gly Met Ala Ser Val Gln Gly 
        915                 920                 925             


Lys Ala Lys Asn Thr Asp Phe Asn Leu Thr Ser Gln Ser Lys Glu Ser 
    930                 935                 940                 


Ile Asp Met Lys Arg Leu Ala Val Met Leu Arg Gly Met Gly Tyr Gln 
945                 950                 955                 960 


Ile Asp Glu Val Ser Arg Thr Glu Phe Val Glu Arg Leu Lys Asn Tyr 
                965                 970                 975     


Pro Leu Glu Gln Trp Asp Glu His Cys Lys Ser Tyr Arg Gln Leu Val 
            980                 985                 990         


Ile Arg Leu Phe Glu Asp Pro Thr  Pro Lys Ile Glu Ser  Phe Tyr Asp 
        995                 1000                 1005             


Gly Ser  Asn Phe Arg Lys His  Val Asp Pro Asn Leu  Leu Val Lys 
    1010                 1015                 1020             


Met Glu  Gln Lys Phe Ile Asp  Thr Trp Phe Glu Lys  Thr Val Asn 
    1025                 1030                 1035             


Phe Leu  Val Ser Asn Asn Ala  Leu Pro Thr Pro Glu  Gly Asn Val 
    1040                 1045                 1050             


Tyr Asp  Asp Glu Ile Lys Thr  Leu Leu Thr Trp Gly  Gln His Lys 
    1055                 1060                 1065             


Gly Glu  Phe Thr His Gln Gln  Cys Ile His His Val  Phe Ala Gln 
    1070                 1075                 1080             


Gln Val  Gln Arg Thr Pro Glu  Ala Ile Ala Val Arg  Phe Asn Gln 
    1085                 1090                 1095             


Asp Ser  Leu Thr Tyr Gln Glu  Leu Asn Glu Arg Ser  Glu Gln Val 
    1100                 1105                 1110             


Ala Gln  Tyr Leu Arg Asn His  Ala Ile Ala Pro Gly  Ala Val Val 
    1115                 1120                 1125             


Gly Leu  Cys Ile Glu Arg Ser  Thr His Leu Ile Val  Ser Ile Leu 
    1130                 1135                 1140             


Ala Ile  Phe Lys Ala Gly Cys  Ala Tyr Leu Pro Leu  Asp Pro Asn 
    1145                 1150                 1155             


Tyr Pro  Ala Ala Ser Leu Asp  His Met Ile Glu Asp  Cys Ala Val 
    1160                 1165                 1170             


Lys His  Ile Leu Val Ala Asn  Lys Ser Pro Gln Ala  Leu Val Leu 
    1175                 1180                 1185             


His Arg  Glu Lys Leu Ile Ser  Leu Thr Asp Val Asp  Phe Ala Met 
    1190                 1195                 1200             


Tyr Ala  Ala Ser Glu Leu Ala  Pro Gly Ile Ser Asn  Thr Gly Gln 
    1205                 1210                 1215             


Gln Ser  Arg Pro Ser Asp Leu  Ala Tyr Val Ile Tyr  Thr Ser Gly 
    1220                 1225                 1230             


Thr Thr  Gly Lys Pro Lys Gly  Val Gln Val Glu His  Arg Ser Val 
    1235                 1240                 1245             


Val Asn  His Ser Leu Ser Met  Ala Asp Val Phe Gly  Leu Thr Gly 
    1250                 1255                 1260             


Gln Asp  Asn Val Leu Gln Phe  Ser Thr Ile Asn Phe  Asp Ser Phe 
    1265                 1270                 1275             


Ile Glu  Glu Val Phe Pro Ser  Leu Phe Thr Gly Ala  Thr Val Val 
    1280                 1285                 1290             


Met Ile  Glu Gln Glu Lys Leu  Thr Gln Val Ser Glu  Leu Thr Glu 
    1295                 1300                 1305             


Leu Ile  Leu Gln Gln Ser Val  Asn Val Val Lys Phe  Ser Thr Ala 
    1310                 1315                 1320             


Tyr Trp  His Thr Val Ser Lys  Val Asn Leu Gln Gln  Leu Gly Val 
    1325                 1330                 1335             


Arg Leu  Leu Ala Ile Gly Gly  Glu Glu Ala Asp Ile  Gln Lys Tyr 
    1340                 1345                 1350             


Asn Glu  Trp Arg Val Ile Asn  Thr Asp Ile Pro Leu  Ile Asn Thr 
    1355                 1360                 1365             


Tyr Gly  Pro Thr Glu Thr Thr  Val Ser Ala Ser Tyr  Ser Val Leu 
    1370                 1375                 1380             


Asn Gly  Pro Leu Asp Asn Ile  Thr Ile Gly Arg Pro  Ile Ala Asn 
    1385                 1390                 1395             


Thr Gln  Ala Tyr Ile Leu Asp  Ser Asn Leu Val Pro  Val Ala Ile 
    1400                 1405                 1410             


Gly Phe  Val Gly Glu Leu Tyr  Ile Ala Gly Glu Gly  Val Ser Arg 
    1415                 1420                 1425             


Gly Tyr  Leu Asn Asn Ala Glu  Leu Thr Ala Gln Val  Phe Ile Asp 
    1430                 1435                 1440             


Asn Pro  Phe Ser Gly His Ser  Lys Met Tyr Lys Thr  Gly Asp Leu 
    1445                 1450                 1455             


Val Arg  Trp Asp Asn Ala Gly  Asn Ile Glu Phe Met  Gly Arg Thr 
    1460                 1465                 1470             


Asp Asn  Gln Val Lys Val Arg  Gly Tyr Arg Ile Glu  Leu Gly Ala 
    1475                 1480                 1485             


Ile Glu  Ser Val Leu Asn Asp  Tyr Gln Gly Ile Ser  Gln Ala Val 
    1490                 1495                 1500             


Val Val  Leu Lys Gln Ile Glu  Thr Lys Lys Lys Val  Val Ala Tyr 
    1505                 1510                 1515             


Val Val  Ala Asn Asn Glu Ala  Ile Asp Ile Ala Glu  Leu Gly Glu 
    1520                 1525                 1530             


His Leu  Ser Gln Ala Leu Pro  Ser Tyr Met Leu Pro  Asn Leu Ile 
    1535                 1540                 1545             


Leu Pro  Leu Asp Asp Ile Pro  Leu Asn Pro Asn Gly  Lys Val Asp 
    1550                 1555                 1560             


Arg Gly  Leu Leu Glu Lys Met  Glu Ile Asn Ser Glu  Lys Ser Ile 
    1565                 1570                 1575             


Asn Phe  Thr Ser Pro Val Thr  Asp Asn Glu Ile Lys  Met Thr Ala 
    1580                 1585                 1590             


Ile Trp  Gln Asp Val Leu Ala  Val Ser Ser Val Gly  Leu His Asp 
    1595                 1600                 1605             


Asp Phe  Met Glu Leu Gly Gly  His Ser Leu Leu Val  Met Ser Leu 
    1610                 1615                 1620             


Ile Ser  Glu Val Asn Gln Glu  Phe Asn Ala Asn Val  Ser Ile Asn 
    1625                 1630                 1635             


Asp Ile  Tyr Glu Ser Ala Thr  Val Ala Lys Leu Leu  Ala Val Val 
    1640                 1645                 1650             


Glu Asn  Asn Asp Tyr Glu Gln  Gly Ser Asn Leu Val  Glu Phe Pro 
    1655                 1660                 1665             


Asn Val  His Leu Ser Lys Thr  Glu Leu Thr Gln Val  Lys Pro Leu 
    1670                 1675                 1680             


Phe Leu  Val His Gly Leu Gly  Gly His Leu Ala Ser  Phe Tyr Pro 
    1685                 1690                 1695             


Leu Val  Lys Asn Leu Lys Gln  Gln Leu His Asp Val  Tyr Asp Ile 
    1700                 1705                 1710             


Asp Ile  Ala Val Tyr Gly Leu  Glu Ala Asn Gly Phe  Lys Ala Gln 
    1715                 1720                 1725             


Gln Gln  His Phe Ala Ser Val  Asp Glu Met Val Ser  Glu Tyr Ile 
    1730                 1735                 1740             


Lys Leu  Ile Lys Ala Lys Gln  Ala Ser Gly Pro Tyr  Leu Ile Gly 
    1745                 1750                 1755             


Gly Trp  Ser Tyr Gly Val Ser  Ile Ala Tyr His Ile  Val Gln Ala 
    1760                 1765                 1770             


Leu Ile  Asn Gln Gly Asp Glu  Val Glu Val Phe Ile  Ser Ile Asp 
    1775                 1780                 1785             


Ala Glu  Ala Pro Tyr Val Pro  Lys Asp Phe Ala Glu  Phe Leu Arg 
    1790                 1795                 1800             


Asp Asn  Asp Val Ser Gly Leu  Asn Asp Leu Tyr Gln  Asp Glu Lys 
    1805                 1810                 1815             


Leu Ala  Ala Leu Leu Lys Asn  Phe Gly Lys Arg Phe  Gly Phe Ile 
    1820                 1825                 1830             


Ser Asn  Asp Lys Glu Cys Ile  Lys Gln Gln Phe Tyr  Arg Phe Leu 
    1835                 1840                 1845             


Gly Tyr  Ser Gln Asp Asp Ser  Gln Asp Gln Val Glu  Arg Phe Asn 
    1850                 1855                 1860             


Lys Val  Ala Ile Ala Asn Leu  Leu Asn Ala Lys Asp  Phe Asn Pro 
    1865                 1870                 1875             


Ser Thr  Ile Asn Pro Val Asn  Ser Leu Leu Val Lys  Ala Ser Gln 
    1880                 1885                 1890             


Ser Val  Phe Asp Asp Tyr Val  Ala Asp Trp Tyr Asp  Leu Leu Asp 
    1895                 1900                 1905             


Ser Lys  Met Ile Ser Leu Leu  Thr Leu Thr Gly Asp  His Trp Ser 
    1910                 1915                 1920             


Ile Met  Gln Glu Gln Glu Leu  Ala Ser Asn Leu Ala  Arg Val Leu 
    1925                 1930                 1935             


Ala Val  Ser Ser Gln Val Val  Ile Asn Glu Ser 
    1940                 1945                 


<210>  39
<211>  5850
<212>  DNA
<213>  Shewanella violacea DSS12

<400>  39
atggaaccta agtcgttcaa cttagcggaa caaacatctt tggttgctgt tttacagcac     60

agagcgcaaa ttacgccaaa taaagttgcc tatatttatt tagaaaatgg tgaagatatt    120

gaagtgccta tcacctacgc tgaattagat tgccgagctc gtgaactcgc ggcgcaatta    180

caagggaaaa acccactgat tcagcaagag cgtgtgctac taatctatcc tcaagggatt    240

gattttatag tggcattttt tgccaccttg tacgcggggg cgatcgctgt gttggtgtat    300

ccacccagca gtaagaaaat ggctcaacgc ttaaatggca tagtcgaaga ttgtaacgtg    360

aaattgattt tatcgacggc taaagtgatt agtcgtatgg atcggatgaa catggtgacc    420

gatgcaggcg aacaagatga agatgccatt aatatcccgg cgcaatactg gataaatagc    480

gacaacttag atcctgaggc ggccagggat tttaagcagc ctattattct aggtgagcat    540

cttgcctttt tacaatacac ctccggctcc acaggtactc caaaaggcgt gatgataagt    600

cacagtaact taatggccaa ccaggccgcg atcaaggata tttatcaaca tgacgacaaa    660

acgatttttg tcggctggtt gccgcttatt catgatatgg gtctgattgg taatgtatta    720

caacccatgt atttaggcat ctccttggtg tttatgtcgc cactgcattt cgtgcaaaaa    780

ccggtacgtt ggctacgtgc tatcagtaag tatcaagcga ccaccagtgg cggccctaat    840

tttgcctatg acttgtgtgt gcgaaaaata gccgatgctg atttggccga cttagaccta    900

tccagttgga cgctggcata caatggcgcc gagcccgttc gcaaagaaac tgtgagtcgt    960

tttaatcaaa ggtttagcgt ctgtgggctc aagcctgagt cgcatatggc ggtatatggt   1020

ttagccgaag ccaccttaat cgtaaccggc accaacaaac aagcggtatt agccactagt   1080

gataatgtcg attatatgtc atctggaaca tgtgttgagg tcgacagggt cagaattgtt   1140

aaccctgaaa cttgcgtcga ggctgatgag caacaagagg gcgaaatttg ggtgcatggc   1200

ccgagcgtag ccaagggtta ttggaatcgc ccagaagaaa ctcaaacgac ttttaaggcg   1260

cagatcctcg gcagcgagct gcattatatg cgcaccggtg atacaggtta ctgcaaaaat   1320

ggtgaaatcc atgtcacagg tcgtattaaa gatatcgtta tcgtgcaagg gaaaaacttc   1380

cacccagagg acatcgaatg gagccttatc gatgtgcagg gtctgcgagt tggcggcagc   1440

gtggcattct cattagatgt ggttgatgag cagggccaaa ccagtgaatc cttggtggtt   1500

gtggcgggcg tattagagtc agatagtgac aagcacccca gcatcatcag taatattcgc   1560

tcgtttatct atcaagacca tcaattgcaa gttgaccgtg tggtgctgat taaacctaag   1620

caaatcccca tgaccaccag tggcaaggta cagcgtcgtt taacccgtca aatgttggtg   1680

gccaatgaat ttaccatcct tggtgacgac ctgttagcgg ctgtcgatga taaatcgact   1740

caagccaggt ctagtattgt tgcagctacc accaaagctg agctggaatt aaccagtatg   1800

tggggcgcaa tcttagggtt atcggccagc gatatcggca tcacagataa cttctttgat   1860

ttaggtggtt cctcattgac catgttggag ctatcaattc agttaaatac caccatggag   1920

ctgttatttc gctacccaac tattagttca tatttatatc gcactagcga gtatgagttt   1980

ccagaagtcg agaaagatat ctatttaccg gcagccaata tagacaggag tttagaaggt   2040

gaaactggta ttagcttgat caccggtggt actggattct ttggcttaca ttttctgcaa   2100

agtatgatgc agcgtaccca ggacaaattt gttttgttaa ttcgtggcga aaatgatgac   2160

gtcatgaaca aaaagtttac cgatgcagtg gcttatttcc atatggaaaa agacatagat   2220

ataggcagag tgatcttaat taggggggat ttaagtgagc accatgtagg tattcctgat   2280

gataagtacc cttgggtttg ccagaatgtg gataagattt tccatatcgg ctcccatgtc   2340

aataactggc tcccctatga aggcatacgc gagatcaatg tcgatggcac tcggagctta   2400

ttggcgcttg ctcgtaccgg acgtaagaag gagttccact ataccagtac cagtactttc   2460

tcaccggata aagccgatcc gtctgtgttc ctagaaggcg atactatcga taaaaacgat   2520

atcaatcgtt tctttggtta tgacataagt aaatatgcca gtgagcaaat gtgccgtatt   2580

gctagagaag aagggcttat ttgtaatatc tatcgtttgg tctggatagg cggtcatatc   2640

gagaccgggc taactaagct caacgatggc tttaatatta tgctgcgtat tttaatcacc   2700

attaaagcct ttcctaaggg aaattatctc cacgatatta ccccggtaga tctattggct   2760

gatggtatgg catcggtgca aggtaaagcc aaaaataccg actttaactt aaccagtcag   2820

tcgaaagaat ccatcgacat gaaacgttta gccgtgatgt tgcgtggcat gggttatcaa   2880

atcgatgagg tgagtcgtac cgaatttgtt gagcgtctaa aaaattaccc attggagcaa   2940

tgggatgagc attgtaagtc gtaccgccaa ctggtgatcc gcttatttga agaccccacg   3000

cctaaaatag aatcttttta tgatggtagt aacttcagaa agcatgttga tccaaacttg   3060

ctggttaaga tggagcaaaa attcatcgat acctggttcg aaaagacggt caacttctta   3120

gtcagtaata atgccctgcc tacaccggag gggaatgttt atgatgatga aattaagacc   3180

ttattgacct ggggccagca taagggtgag ttcacacatc aacaatgtat acaccatgta   3240

tttgcccaac aagtacaaag aaccccagag gcgattgcgg ttaggtttaa tcaagacagt   3300

ttaacctatc aggagttgaa tgagcgtagc gagcaagtag cccaatactt gcgtaatcat   3360

gccattgccc ccggtgctgt ggtgggctta tgtatcgagc gttccacaca cttgattgta   3420

tccatcttgg ccatcttcaa agccggttgc gcctatttac cattggaccc taattatccc   3480

gccgcgagtc tggatcatat gatagaagac tgcgccgtta agcatatttt agtggccaat   3540

aagtcgccac aagcactagt gcttcatcgg gaaaagctga tttcactgac cgatgttgac   3600

tttgccatgt acgcggccag tgaattagct cccggcatat caaatactgg ccagcaatca   3660

cggccgagtg atctggccta tgtgatttac acttcgggca ccacaggcaa gcctaaaggg   3720

gtacaggttg agcataggag tgtggtgaat cacagtttaa gtatggctga tgtgtttggt   3780

ttgactggac aagataatgt attacagttc tcaaccatca actttgattc ttttatcgaa   3840

gaagtgtttc ccagcttatt tactggcgct actgtggtga tgattgagca ggagaagctt   3900

acccaagtga gcgagctaac tgagttaatt ctccagcagt cggtcaacgt ggttaagttc   3960

tccaccgcct actggcacac tgtgtctaag gttaacttgc agcaactggg tgtgcgattg   4020

ttagccatag ggggtgaaga ggccgatatt cagaaataca atgagtggcg agtcattaat   4080

accgatattc cccttatcaa cacctatggg ccaactgaga cgacagtgag cgccagttac   4140

tcagtattaa atggtccgct cgataacatc accataggcc ggccaattgc caatacccaa   4200

gcttacatct tggacagtaa cttggttcct gtggccattg gctttgtggg tgaactctat   4260

attgctggtg aaggggtcag tcggggttat ctcaataatg ccgagcttac cgcgcaagtg   4320

tttattgata atccttttag cggtcattct aagatgtata aaacagggga tctggtacgt   4380

tgggacaatg ccggtaatat tgagtttatg ggccgcacag acaaccaggt gaaagttcgc   4440

ggttatcgta tcgagctcgg cgccattgaa agtgtgttaa atgactatca aggtattagc   4500

caggccgtgg tagtgctgaa gcaaattgaa accaagaaga aagtggttgc ctatgttgtg   4560

gccaataatg aggcgattga tattgccgag ctaggggagc atctatccca agccttgcct   4620

agttatatgc tgcctaatct aatattacct ctcgatgata ttcctctcaa tcccaacggc   4680

aaagttgatc gtggcttgct agaaaagatg gagattaata gtgagaaaag tattaatttc   4740

acctctccgg tgacggataa tgaaatcaaa atgacggcca tttggcaaga tgtattggcg   4800

gtatcgagtg tcggtttaca tgatgacttc atggagcttg gtggccactc attgctagtt   4860

atgtcgctta taagtgaagt gaaccaagag tttaatgcta atgtcagtat caatgatatt   4920

tatgagtcgg cgacggttgc caagttactc gccgtggtcg aaaataatga ctatgagcaa   4980

gggtctaatt tggttgaatt tcccaacgtt cacctctcta agactgagtt aactcaggtt   5040

aaacctctgt tcttagtcca tggtctaggg gggcatctag cgtctttcta tcccttggtg   5100

aagaacttaa agcagcagtt acatgatgtg tatgatattg atattgcagt ttatggccta   5160

gaagccaatg gttttaaggc tcagcagcaa cactttgcca gtgtcgatga gatggtgagt   5220

gaatacatta aactgataaa ggctaagcag gcatcgggcc catacctgat aggtggctgg   5280

tcttatggcg tctcgattgc ttaccacata gtgcaagcgc tcattaatca gggcgatgaa   5340

gtcgaggtgt ttatctccat agatgctgag gcaccctatg tgccaaaaga ctttgcagag   5400

ttcttgcgag acaatgatgt ctctggtttg aatgacttat atcaggatga aaaactggcg   5460

gcgctgttga aaaacttcgg caaacgtttt ggctttatca gtaatgacaa agagtgtatt   5520

aagcagcagt tttatcgctt tttaggctat tcacaagatg atagtcaaga ccaagtcgag   5580

cgcttcaata aggtggccat agccaatctg ttaaatgcta aggactttaa ccccagcaca   5640

attaacccgg ttaattcgct cttagttaaa gcatcacaga gtgtcttcga tgattacgtc   5700

gccgattggt atgacttact cgacagtaag atgatatcac tgcttacttt aaccggagat   5760

cattggtcca ttatgcagga gcaagaattg gcaagtaatt tagcaagagt actcgctgtt   5820

agctcacagg tggtaattaa cgagagctag                                    5850


