                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum Stiftung des ffentlichen 
       Rechts
 
<120>  Human TERT promoter variants, as well as kits, methods and uses 
       thereof

<130>  D68843PC

<150>  US 61/885,614
<151>  2013-10-02

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  1
gcccgacgcc ccgcgtccgg acctggaggc agccctgggt ctccggatca ggccagcggc       60

caaagggtcg ccgcacgcac ctgttcccag ggcctccaca tcatggcccc tccctcgggt      120

taccccacag cctaggccga ttcgacctct ctccgctggg gccctcgctg gcgtccctgc      180

accctgggag cgcgagcggc gcgcgggcgg ggaagcgcgg cccagacccc cgggtccgcc      240

cggagcagct gcgctgtcgg ggccaggccg ggctcccagt ggattcgcgg gcacagacgc      300

ccaggaccgc gcttcccacg tggcggaggg actggggacc cgggcacccg tcctgcccct      360

tcaccttcca gctccgcctc ctccgcgcgg accccgcccc gtcccgaccc ctcccgggtc      420

cccggcccag ccccctccgg gccctcccag cccctcccct tcctttccgc ggccccgccc      480

tctcctcgcg gcgcgagttt caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg      540

gccccggcca cccccgcgat gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg      600

cgcagccact accgcgaggt gctgccgctg gccacgttcg t                          641


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT_F primer

<400>  2
acgaacgtgg ccagcggcag                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT_R primer

<400>  3
ctggcgtccc tgcaccctgg                                                   20


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT_short_F primer

<400>  4
cagcgctgcc tgaaactc                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT_short_R primer

<400>  5
gtcctgcccc ttcacctt                                                     18


<210>  6
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT_cloning_F primer

<400>  6
ctggtactga atccactgtt tcatttg                                           27


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT_cloning_R primer

<400>  7
ctctccgcat gtcgctggtt                                                   20


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  501288_F primer

<400>  8
cagctaatta agcacacaat gg                                                22


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  501288_R primer

<400>  9
accttgaaag gtccttggag                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1036775_F primer

<400>  10
tccttccaca gctacctgtt g                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1036775_R primer

<400>  11
catccacact actggacgac                                                   20


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1073496_F primer

<400>  12
ccccagtgag cctgaac                                                      17


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1073496_R primer

<400>  13
ggcggtggct ttgagctc                                                     18


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1140303_F primer

<400>  14
gcatcaaacg ctccgaggtc                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1140303_R primer

<400>  15
ggatcacatg cctcatcgcc tg                                                22


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1140764_F primer

<400>  16
ggaggcgtca ttctgtaaac agg                                               23


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1140764_R primer

<400>  17
aatggccctc ctgggtgaat c                                                 21


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1557614_F primer

<400>  18
cctgtcagct caggtcatgt gtt                                               23


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1557614_R

<400>  19
tctctcatcc acagctggac g                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_1_F primer

<400>  20
cggctgcgga gagggggaga g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_1_R primer

<400>  21
ctccagagtc gcccgccatc c                                                 21


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_1B_F primer

<400>  22
ggaggcggcg agaacat                                                      17


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_1B_R primer

<400>  23
gggcctttcc tacctggtct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_2_F primer

<400>  24
gggctctaca caagcttcct t                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_2_R primer

<400>  25
tttggaagct ctcagggtac a                                                 21


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_3_F primer

<400>  26
gcctgttttc tttctgccct ctg                                               23


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon_3_R primer

<400>  27
cgaaagcggg gtgggttgt                                                    19


<210>  28
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT-Prom-F primer

<400>  28
ctggtactga atccactgtt tcatttg                                           27


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT-Prom-R primer

<400>  29
ctctccgcat gtcgctggtt                                                   20


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTert +65-F primer

<400>  30
agcacctcgc ggtagtgg                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTert -278-R primer

<400>  31
ggattcgcgg gcacagac                                                     18


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
cggaagagtg tctggagca                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
ggatgaagcg gagtctgga                                                    19


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BRAF: exon 15 forward primer

<400>  34
cctaaactct tcataatgct t                                                 21


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BRAF: exon 15 rev primer

<400>  35
atagcctcaa ttcttaccat                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon1 F primer

<400>  36
cggctgcgga gagggggaga g                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon1 rev primer

<400>  37
ggatggcggg cgactctgga g                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon2 F primer

<400>  38
tttggaagct ctcagggtac a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon2 rev primer

<400>  39
gggctctaca caagcttcct t                                                 21


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon2 F primer 2

<400>  40
atgccggtag ggacggcaag                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKN2A: exon2 rev primer 2

<400>  41
aaagcggggt gggttgtggc                                                   20


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRAS: exon 2 F primer

<400>  42
cgccaattaa ccctgattac t                                                 21


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRAS: exon 2 rev primer

<400>  43
cactgggcct cacctcta                                                     18


<210>  44
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRAS: exon3 F primer

<400>  44
ccccttaccc tccacac                                                      17


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NRAS: exon3 rev primer

<400>  45
aggttaatat ccgcaaatga c                                                 21


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT promoter: -27 to -286 F

<400>  46
cccacgtgcg cagcaggac                                                    19


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT promoter: -27 to -286 rev

<400>  47
ctcccagtgg attcgcgggc                                                   20


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ref Figure 4 (1)

<400>  48
agcgctgcct gaaactcg                                                     18


<210>  49
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reference from Figure 4 (2)

<400>  49
gcccggaggg ggctgggccg gggacccggg aggg                                   34


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wt seq Figure 14

<400>  50
acccctcccg ggtccccggc ccagccccct ccgggc                                 36


<210>  51
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant Figure 14 (2)

<400>  51
accccttccg ggtccccggc ccagcccctt ccgggc                                 36


<210>  52
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wt Figure 14(2)

<400>  52
gagtttcagg cagcg                                                        15


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant seq Figure 14 (2)

<400>  53
gagtttccgg cagcg                                                        15


<210>  54
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of Figure 13

<400>  54
acgcagcgct gccggaaact cgcgccgacg cagcgctgcc tgaaactcgc gccggggagg       60

gcccggaagg ggctgggccg gggagggccc ggagggggct gggccg                     106


<210>  55
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Figure 13, sequence on right side

<400>  55
gccggggacc cgggaggggt cgggacggcc ggggacccgg gaggggtcgg gacgggaggg       60

ggctgggccg ggaacccggg agggaggggg tgggccgggg acccggaagg                 110


<210>  56
<211>  161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Figure 14, sequence portion of TERT promoter

<400>  56
gtcccgaccc ctcccgggtc cccggcccag ccccctccgg gccctcccag cccctcccct       60

tcctttccgc ggccccgccc tctcctcgcg gcgcgagttt caggcagcgc tgcgtcctgc      120

tgcgcacgtg ggaagccctg gccccggcca cccccgcgat g                          161


<210>  57
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Figure 17b, upper sequence, first half

<400>  57
gaccccttcc gggtttccgg cccagcccct tccgggcc                               38


<210>  58
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fig. 17b, upper sequence, second half

<400>  58
agtttcgggc ag                                                           12


<210>  59
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Figure 17b, lower sequence, first half

<400>  59
gacccctccc gggtccccgg cccagccccc tccgggcc                               38


<210>  60
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Figure 17b, lower sequence, second half

<400>  60
agtttcaggc ag                                                           12


<210>  61
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT promoter sequence of Figure 19

<400>  61
gccccttccg ggccctccca gcccctcccc ttcctttctg cgg                         43


