                         SEQUENCE LISTING

<110>  Viventia Bio Inc
 
<120>  ANTI-EPCAM ANTIBODIES AND METHODS OF USE

<130>  11169/00002

<150>  PCT/CA2014/
<151>  2014-10-02

<140>  61/865,817
<141>  2013-10-02

<140>  61/030,805
<141>  2014-07-30

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  de-immunized VH-CH or DI VH-CH

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  2
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  de-immunized VL-CL or DI VL-CL

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Thr Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  3
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETA toxin 252-608

<400>  3

Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
1               5                   10                  15      


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
            20                  25                  30          


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
        35                  40                  45              


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
    50                  55                  60                  


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
65                  70                  75                  80  


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
                85                  90                  95      


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
            100                 105                 110         


Ser Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
        115                 120                 125             


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
    130                 135                 140                 


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
145                 150                 155                 160 


Arg Gly Thr Gln Asn Trp Thr Glu Arg Leu Leu Gln Ala His Arg Gln 
                165                 170                 175     


Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu 
            180                 185                 190         


Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln 
        195                 200                 205             


Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala 
    210                 215                 220                 


Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg 
225                 230                 235                 240 


Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu 
                245                 250                 255     


Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Glu Val Glu Arg Leu Leu Gly His Pro Leu Pro Leu Arg Leu Asp 
        275                 280                 285             


Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu 
    290                 295                 300                 


Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro 
305                 310                 315                 320 


Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro 
                325                 330                 335     


Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro 
            340                 345                 350         


Gly Lys Pro Pro 
        355     


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified bouganin protein

<400>  4

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  5
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type VH-CH or WT VH-CH

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  6
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type VL-CL or WT VL-CL

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  7
<211>  1588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of de-immunized VB5-845

<400>  7
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcggaagt acagctggtc gaatccggtg gtggtctggt tcagccgggt ggtagcctgc      180

gtctgagctg cgcggcgagc ggttacacct tcaccgcgta cggtatgaac tgggttcgtc      240

aggctccggg taaaggtttg gaatggatgg gttggatcaa cacctatacc ggtgagtcta      300

cctacgctga tagcgttaaa ggccgtttca ccatcagcgc tgacactagc aaaaacaccg      360

cgtacctgca gatgaactct ctgcgtgctg aggacactgc ggtttactac tgcgctcgtt      420

tcgcgatcaa aggtgactat tggggtcagg gtactctggt taccgttagc agcgctagca      480

ctaagggccc gtccgttttc ccactggctc cgtcttctaa aagcacttct ggtggtaccg      540

cggctctggg ttgccttgtt aaagactact tccctgaacc ggtcaccgtt agctggaact      600

ccggtgcgtt gacctctggt gttcacacct tcccagcggt tctgcagtct agcggtctgt      660

atagcctgag ctctgtagtt accgttccgt cttctagcct gggtacgcag acctacatct      720

gcaacgtgaa ccacaaaccg agcaacacta aagtggataa aaaagttgaa ccgaagtctt      780

gctagtaatc tagagtcgac ctgcaggtct atggaacgat aaatgcccat gaaaattcta      840

tttcaaggag acagtcataa tgaaatacct tctgccgacc gctgccgctg gtctgctgct      900

gttggctgct caaccggcta tggcagacat ccagatgacc cagtccccgt ctagcctgag      960

cgcaagcgtt ggtgaccgtg tgaccatcac ctgccgtagc actaaatccc tgctgcactc     1020

taacggcatc acctacctgt attggtacca acagaaaccg ggtaaagctc cgaaactgct     1080

gatctaccag atgtctaacc tggctagcgg cgttccttct cgtttttctt ctagcggtag     1140

cggtactgac ttcaccctga ccattagctc tctgcagcct gaagactttg cgacctacta     1200

ttgcgctcag aaccttgaaa tcccgcgtac cttcggcacc ggtaccaaag ttgaaatcaa     1260

gcgtaccgtt gcggctccgt ctgttttcat cttcccacct agcgatgaac agcttaaatc     1320

tggtactgct agcgtagttt gcctgcttaa caacttctac cctcgtgaag ctaaagttca     1380

gtggaaagtt gacaacgctc tgcagtctgg taactctcag gaatctgtga ccgaacagga     1440

tagcaaagat agcacctata gcctgtctag caccctgacc cttagcaagg cggactatga     1500

aaaacacaaa gtttacgctt gcgaggtgac ccaccaaggt ctgtcttctc cggtgactaa     1560

atcctttaac cgtggcgaat gctagtga                                        1588


<210>  8
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5MOC-B

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Thr Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro 
        115                 120                 125             


Thr Ala Asn Ser Gly Thr Ser Gly Ser Glu Val Gln Leu Val Gln Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln 
                165                 170                 175     


Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr 
            180                 185                 190         


Gly Glu Ser Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser 
        195                 200                 205             


Leu Asp Thr Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
                245                 250             


<210>  9
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified bouganin protein


<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Xaa is Thr or Ala or Gln

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  Xaa is Gln or Gly or Glu

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Xaa is Asn or Asp or Thr or Ala or Arg or Gln or Glu or Gly or 
       His or Lys or Ser

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa is Gln or Ala

<400>  9

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Xaa Asp Arg Lys Xaa Leu 
        115                 120                 125             


Xaa Leu Gly Val Xaa Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Xaa Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  10
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB6-845

<400>  10

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser 
65                  70                  75                  80  


Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Tyr Asn Thr 
                245                 250                 255     


Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln 
            260                 265                 270         


Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys Gln Leu Pro 
        275                 280                 285             


Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val Leu Val Asp 
    290                 295                 300                 


Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile Asp Val Thr 
305                 310                 315                 320 


Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg 
                325                 330                 335     


Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser Lys Leu Phe 
            340                 345                 350         


Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln 
        355                 360                 365             


Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly 
    370                 375                 380                 


Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly Lys Thr Ile 
385                 390                 395                 400 


Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile Gln Met Val 
                405                 410                 415     


Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val Val Asp Arg 
            420                 425                 430         


Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu Asn Leu Glu 
        435                 440                 445             


Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser Ser Pro Gln 
    450                 455                 460                 


Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp 
465                 470                 475                 480 


Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp Met Gly Ile 
                485                 490                 495     


Leu Lys Phe Lys Ser Ser Lys Met Lys Tyr Leu Leu Pro Thr Ala Ala 
            500                 505                 510         


Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala His His His 
        515                 520                 525             


His His His Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    530                 535                 540                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu 
545                 550                 555                 560 


Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro 
                565                 570                 575     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser 
            580                 585                 590         


Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr 
        595                 600                 605             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    610                 615                 620                 


Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val 
625                 630                 635                 640 


Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
                645                 650                 655     


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
            660                 665                 670         


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
        675                 680                 685             


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
    690                 695                 700                 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
705                 710                 715                 720 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
                725                 730                 735     


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            740                 745                 750 


<210>  11
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH-CH

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Gln Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  12
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VL-CL

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser His Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  13
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VH-CH-deBouganin

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  14
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH-CH-deBouganin

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Gln Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  15
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VH-CH-deBouganin

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  16
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VL-CL-deBouganin

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Thr Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  17
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VL-CL-deBouganin

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser His Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  18
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VL-CL-deBouganin

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  19
<211>  788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of DI VH-CH

<400>  19
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcggaagt acagctggtc gaatccggtg gtggtctggt tcagccgggt ggtagcctgc      180

gtctgagctg cgcggcgagc ggttacacct tcaccgcgta cggtatgaac tgggttcgtc      240

aggctccggg taaaggtttg gaatggatgg gttggatcaa cacctatacc ggtgagtcta      300

cctacgctga tagcgttaaa ggccgtttca ccatcagcgc tgacacttct aaaaacaccg      360

cgtacctgca gatgaactct ctgcgtgctg aggacactgc ggtttactac tgcgctcgtt      420

tcgcgatcaa aggtgactat tggggtcagg gtactctggt taccgttagc agcgctagca      480

ctaagggccc gtccgttttc ccactggctc cgtcttctaa aagcacttct ggtggtaccg      540

cggctctggg ttgccttgtt aaagactact tccctgaacc ggtcaccgtt agctggaact      600

ccggtgcgtt gacctctggt gttcacacct tcccagcggt tctgcagtct agcggtctgt      660

atagcctgag ctctgtagtt accgttccgt cttctagcct gggtacgcag acctacatct      720

gcaacgtgaa ccacaaaccg agcaacacta aagtggataa aaaagttgaa ccgaagtctt      780

gctagtaa                                                               788


<210>  20
<211>  788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of DI VL-CL

<400>  20
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct tctgccgacc gctgccgctg gtctgctgct gttggctgct caaccggcta      120

tggcagacat ccagatgacc cagtccccgt ctagcctgag cgcaagcgtt ggtgaccgtg      180

tgaccatcac ctgccgtagc actaaatccc tgctgcactc taacggcatc acctacctgt      240

attggtacca acagaaaccg ggtaaagctc cgaaactgct gatctaccag atgtctaacc      300

tggctagcgg cgttccttct cgtttttctt ctagcggtag cggtactgac ttcaccctga      360

ccattagctc tctgcagcct gaagactttg cgacctacta ttgcgctcag aaccttgaaa      420

tcccgcgtac cttcggcacc ggtaccaaag ttgaaatcaa gcgtaccgtt gcggctccgt      480

ctgttttcat cttcccacct agcgatgaac agcttaaatc tggtactgct agcgtagttt      540

gcctgcttaa caacttctac cctcgtgaag ctaaagttca gtggaaagtt gacaacgctc      600

tgcagtctgg taactctcag gaatctgtga ccgaacagga tagcaaagat agcacctata      660

gcctgtctag caccctgacc cttagcaagg cggactatga aaaacacaaa gtttacgctt      720

gcgaggtgac ccaccaaggt ctgtcttctc cggtgactaa atcctttaac cgtggcgaat      780

gctagtga                                                               788


<210>  21
<211>  788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of WT VH-CH

<400>  21
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcggaagt acagctggtt cagtccggcc cgggtcttgt tcaaccgggt ggttccgttc      180

gtatctcttg cgctgcttct ggttacacgt tcaccaacta cggcatgaac tgggtcaaac      240

aggctccggg taaaggcctg gaatggatgg gctggatcaa cacctacacc ggtgaatcca      300

cctacgctga ctccttcaaa ggtcgcttca ctttctccct cgacacaagt gctagtgctg      360

catacctcca aatcaactcg ctgcgtgcag aggatacagc agtctattac tgcgcccgtt      420

tcgctatcaa aggtgactac tggggtcaag gcacgctgct gaccgtttcc tcggctagca      480

ccaaaggccc atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag      540

cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact      600

caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct      660

actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct      720

gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag cccaaatctt      780

gttagtga                                                               788


<210>  22
<211>  806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of WT VL-CL

<400>  22
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcgcacca tcatcaccat cacgatatcc agatgaccca gtccccgtcc tccctgagtg      180

cttctgttgg tgaccgtgtt accatcacct gccgttccac caaatccctc ctgcactcca      240

acggtatcac ctacctttat tggtatcaac agaaaccggg taaagctccg aaacttctga      300

tctaccagat gtccaacctg gcttccggtg ttccgtctcg tttctccagt tctggttctg      360

gtaccgactt caccctgacc atctcttctc tgcagccgga agacttcgct acctactact      420

gcgctcagaa cctggaaatc ccgcgtacct tcggtcaggg taccaaagtt gaacttaagc      480

gcactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg      540

gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt      600

ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca      660

gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga      720

aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga      780

gcttcaacag gggagagtgt tagtga                                           806


<210>  23
<211>  794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Algo VH-CH

<400>  23
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc ggaagtacag ctgcagcagt ccggtccggg tctggttcag ccgggtggta      180

gcgttcgtat tagctgcgcg gcgagcggtt acaccttcac cgcgtacggt atgaactggg      240

ttcgtcaggc tccgggtaaa ggtttggaat ggatgggttg gatcaacacc tataccggtg      300

agtctaccta cgctgatagc ttcaaaggcc gtttcgaatt tagccttgac actcacaaca      360

gctctgcgta cctgcagatt cagtctctgc gtgaagagga cactgcggtt tactactgcg      420

ctcgtttcgc gatccagggt gactattggg gtcagggtac tctggttacc gttagcagcg      480

ctagcactaa gggcccgtcc gttttcccac tggctccgtc ttctaaaagc acttctggtg      540

gtaccgcggc tctgggttgc cttgttaaag actacttccc tgaaccggtc accgttagct      600

ggaactccgg tgcgttgacc tctggtgttc acaccttccc agcggttctg cagtctagcg      660

gtctgtatag cctgagctct gtagttaccg ttccgtcttc tagcctgggt acgcagacct      720

acatctgcaa cgtgaaccac aaaccgagca acactaaagt ggataaaaaa gttgaaccga      780

agtcttgcta gtaa                                                        794


<210>  24
<211>  794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Algo VL-CL

<400>  24
tctagagtcg acctgcaggt ctatggaacg ataaatgccc atgaaaattc tatttcaagg       60

agacagtcat aatgaaatac cttctgccga ccgctgccgc tggtctgctg ctgttggctg      120

ctcaaccggc tatggcagac atccagatga cccagtcccc gtctagcctg agcgcaagcg      180

ttggtgaccg tgtgaccatc acctgcaaaa gcactaaatc cctgctgcac tctaacggca      240

tcacctacct gtattggtac caacagaaac cgggttctgc tccgaaactg ctgatctacc      300

agatgtctca cctggctagc ggcgttcctt ctcgtttttc ttctagcggt agcggtactg      360

acttcaccct gaccattagc tctctgcagc ctgaagactt tgcgacctac tattgcgctc      420

agaaccttga aatcccgcgt accttcggcc agggtaccaa agttgaaatc aagcgtaccg      480

ttgcggctcc gtctgttttc atcttcccac ctagcgatga acagcttaaa tctggtactg      540

ctagcgtagt ttgcctgctt aacaacttct accctcgtga agctaaagtt cagtggaaag      600

ttgacaacgc tctgcagtct ggtaactctc aggaatctgt gaccgaacag gatagcaaag      660

atagcaccta tagcctgtct agcaccctga cccttagcaa ggcggactat gaaaaacaca      720

aagtttacgc ttgcgaggtg acccaccaag gtctgtcttc tccggtgact aaatccttta      780

accgtggcga atgc                                                        794


<210>  25
<211>  1580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of DI VH-CH-deBouganin

<400>  25
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcggaagt acagctggtc gaatccggtg gtggtctggt tcagccgggt ggtagcctgc      180

gtctgagctg cgcggcgagc ggttacacct tcaccgcgta cggtatgaac tgggttcgtc      240

aggctccggg taaaggtttg gaatggatgg gttggatcaa cacctatacc ggtgagtcta      300

cctacgctga tagcgttaaa ggccgtttca ccatcagcgc tgacacttct aaaaacaccg      360

cgtacctgca gatgaactct ctgcgtgctg aggacactgc ggtttactac tgcgctcgtt      420

tcgcgatcaa aggtgactat tggggtcagg gtactctggt taccgttagc agcgctagca      480

ctaagggccc gtccgttttc ccactggctc cgtcttctaa aagcacttct ggtggtaccg      540

cggctctggg ttgccttgtt aaagactact tccctgaacc ggtcaccgtt agctggaact      600

ccggtgcgtt gacctctggt gttcacacct tcccagcggt tctgcagtct agcggtctgt      660

atagcctgag ctctgtagtt accgttccgt cttctagcct gggtacgcag acctacatct      720

gcaacgtgaa ccacaaaccg agcaacacta aagtggataa aaaagttgaa ccgaagtctt      780

gcacccgtca ccgtcagccg cgtggttggg aacagaaata taacaccgta tcttttaacc      840

tgggtgaggc gtatgaatac ccgaccttca tccaggacct gcgtaatgaa cttgctaaag      900

gtacccctgt ttgccagctg cctgtgaccc tgcagaccat cgctgatgat aaacgtttcg      960

ttctggttga cattaccacc acctccaaaa aaaccgttaa agtcgcgatc gatgtgaccg     1020

acgtttacgt ggtaggttac caggataaat gggacggtaa agatcgtgcg gttttcctgg     1080

acaaagttcc gaccgtagcg acttctaaac tgttcccagg tgtgaccaac cgtgtgaccc     1140

tgaccttcga cggcagctat cagaaactgg ttaacgcggc caaagctgat cgtaaagctc     1200

tcgaactggg tgttaacaaa ctggagttca gcattgaagc tatccacggt aaaaccatca     1260

acggtcaaga agcagctaaa ttcttcctga tcgtgatcca gatggttagc gaagcagcgc     1320

gttttaaata cattgaaacc gaagtagttg atcgtggtct gtatggtagc ttcaaaccga     1380

acttcaaagt tcttaacctg gagaacaact ggggtgacat tagcgacgcg atccataaat     1440

cttccccgca atgcaccacc attaacccgg ctctgcagct gatctctccg tctaacgatc     1500

cgtgggtagt taacaaagtg tctcaaatca gcccggacat gggtatcctg aaatttaaat     1560

ctagcaaata gtgactcgag                                                 1580


<210>  26
<211>  1586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Algo VH-CH-deBouganin

<400>  26
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc ggaagtacag ctgcagcagt ccggtccggg tctggttcag ccgggtggta      180

gcgttcgtat tagctgcgcg gcgagcggtt acaccttcac cgcgtacggt atgaactggg      240

ttcgtcaggc tccgggtaaa ggtttggaat ggatgggttg gatcaacacc tataccggtg      300

agtctaccta cgctgatagc ttcaaaggcc gtttcgaatt tagccttgac actcacaaca      360

gctctgcgta cctgcagatt cagtctctgc gtgaagagga cactgcggtt tactactgcg      420

ctcgtttcgc gatccagggt gactattggg gtcagggtac tctggttacc gttagcagcg      480

ctagcactaa gggcccgtcc gttttcccac tggctccgtc ttctaaaagc acttctggtg      540

gtaccgcggc tctgggttgc cttgttaaag actacttccc tgaaccggtc accgttagct      600

ggaactccgg tgcgttgacc tctggtgttc acaccttccc agcggttctg cagtctagcg      660

gtctgtatag cctgagctct gtagttaccg ttccgtcttc tagcctgggt acgcagacct      720

acatctgcaa cgtgaaccac aaaccgagca acactaaagt ggataaaaaa gttgaaccga      780

agtcttgcac ccgtcaccgt cagccgcgtg gttgggaaca gaaatataac accgtatctt      840

ttaacctggg tgaggcgtat gaatacccga ccttcatcca ggacctgcgt aatgaacttg      900

ctaaaggtac ccctgtttgc cagctgcctg tgaccctgca gaccatcgct gatgataaac      960

gtttcgttct ggttgacatt accaccacct ccaaaaaaac cgttaaagtc gcgatcgatg     1020

tgaccgacgt ttacgtggta ggttaccagg ataaatggga cggtaaagat cgtgcggttt     1080

tcctggacaa agttccgacc gtagcgactt ctaaactgtt cccaggtgtg accaaccgtg     1140

tgaccctgac cttcgacggc agctatcaga aactggttaa cgcggccaaa gctgatcgta     1200

aagctctcga actgggtgtt aacaaactgg agttcagcat tgaagctatc cacggtaaaa     1260

ccatcaacgg tcaagaagca gctaaattct tcctgatcgt gatccagatg gttagcgaag     1320

cagcgcgttt taaatacatt gaaaccgaag tagttgatcg tggtctgtat ggtagcttca     1380

aaccgaactt caaagttctt aacctggaga acaactgggg tgacattagc gacgcgatcc     1440

ataaatcttc cccgcaatgc accaccatta acccggctct gcagctgatc tctccgtcta     1500

acgatccgtg ggtagttaac aaagtgtctc aaatcagccc ggacatgggt atcctgaaat     1560

ttaaatctag caaatagtga ctcgag                                          1586


<210>  27
<211>  1580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of WT VH-CH-deBouganin

<400>  27
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcggaagt acagctggtt cagtccggcc cgggtcttgt tcaaccgggt ggttccgttc      180

gtatctcttg cgctgcttct ggttacacgt tcaccaacta cggcatgaac tgggtcaaac      240

aggctccggg taaaggcctg gaatggatgg gctggatcaa cacctacacc ggtgaatcca      300

cctacgctga ctccttcaaa ggtcgcttca ctttctccct cgacacaagt gctagtgctg      360

catacctcca aatcaactcg ctgcgtgcag aggatacagc agtctattac tgcgcccgtt      420

tcgctatcaa aggtgactac tggggtcaag gcacgctgct gaccgtttcc tcggctagca      480

ccaaaggccc atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag      540

cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact      600

caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct      660

actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct      720

gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag cccaaatctt      780

gtacccgtca ccgtcagccg cgtggttggg aacagctcta taacaccgta tcttttaacc      840

tgggtgaggc gtatgaatac ccgaccttca tccaggacct gcgtaatgaa cttgctaaag      900

gtacccctgt ttgccagctg cctgtgaccc tgcagaccat cgctgatgat aaacgtttcg      960

ttctggttga cattaccacc acctccaaaa aaaccgttaa agtcgcgatc gatgtgaccg     1020

acgtttacgt ggtaggttac caggataaat gggacggtaa agatcgtgcg gttttcctgg     1080

acaaagttcc gaccgtagcg acttctaaac tgttcccagg tgtgaccaac cgtgtgaccc     1140

tgaccttcga cggcagctat cagaaactgg ttaacgcggc caaagctgat cgtaaagctc     1200

tcgaactggg tgttaacaaa ctggagttca gcattgaagc tatccacggt aaaaccatca     1260

acggtcaaga agcagctaaa ttcttcctga tcgtgatcca gatggttagc gaagcagcgc     1320

gttttaaata cattgaaacc gaagtagttg atcgtggtct gtatggtagc ttcaaaccga     1380

acttcaaagt tcttaacctg gagaacaact ggggtgacat tagcgacgcg atccataaat     1440

cttccccgca atgcaccacc attaacccgg ctctgcagct gatctctccg tctaacgatc     1500

cgtgggtagt taacaaagtg tctcaaatca gcccggacat gggtatcctg aaatttaaat     1560

ctagcaaata gtgactcgag                                                 1580


<210>  28
<211>  1580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of DI VL-CL-deBouganin

<400>  28
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct tctgccgacc gctgccgctg gtctgctgct gttggctgct caaccggcta      120

tggcagacat ccagatgacc cagtccccgt ctagcctgag cgcaagcgtt ggtgaccgtg      180

tgaccatcac ctgccgtagc actaaatccc tgctgcactc taacggcatc acctacctgt      240

attggtacca acagaaaccg ggtaaagctc cgaaactgct gatctaccag atgtctaacc      300

tggctagcgg cgttccttct cgtttttctt ctagcggtag cggtactgac ttcaccctga      360

ccattagctc tctgcagcct gaagactttg cgacctacta ttgcgctcag aaccttgaaa      420

tcccgcgtac cttcggcacc ggtaccaaag ttgaaatcaa gcgtaccgtt gcggctccgt      480

ctgttttcat cttcccacct agcgatgaac agcttaaatc tggtactgct agcgtagttt      540

gcctgcttaa caacttctac cctcgtgaag ctaaagttca gtggaaagtt gacaacgctc      600

tgcagtctgg taactctcag gaatctgtga ccgaacagga tagcaaagat agcacctata      660

gcctgtctag caccctgacc cttagcaagg cggactatga aaaacacaaa gtttacgctt      720

gcgaggtgac ccaccaaggt ctgtcttctc cggtgactaa atcctttaac cgtggcgaat      780

gcacccgtca ccgtcagccg cgtggttggg aacagaaata taacaccgta tcttttaacc      840

tgggtgaggc gtatgaatac ccgaccttca tccaggacct gcgtaatgaa cttgctaaag      900

gtacccctgt ttgccagctg cctgtgaccc tgcagaccat cgctgatgat aaacgtttcg      960

ttctggttga cattaccacc acctccaaaa aaaccgttaa agtcgcgatc gatgtgaccg     1020

acgtttacgt ggtaggttac caggataaat gggacggtaa agatcgtgcg gttttcctgg     1080

acaaagttcc gaccgtagcg acttctaaac tgttcccagg tgtgaccaac cgtgtgaccc     1140

tgaccttcga cggcagctat cagaaactgg ttaacgcggc caaagctgat cgtaaagctc     1200

tcgaactggg tgttaacaaa ctggagttca gcattgaagc tatccacggt aaaaccatca     1260

acggtcaaga agcagctaaa ttcttcctga tcgtgatcca gatggttagc gaagcagcgc     1320

gttttaaata cattgaaacc gaagtagttg atcgtggtct gtatggtagc ttcaaaccga     1380

acttcaaagt tcttaacctg gagaacaact ggggtgacat tagcgacgcg atccataaat     1440

cttccccgca atgcaccacc attaacccgg ctctgcagct gatctctccg tctaacgatc     1500

cgtgggtagt taacaaagtg tctcaaatca gcccggacat gggtatcctg aaatttaaat     1560

ctagcaaata gtgactcgag                                                 1580


<210>  29
<211>  1592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Algo VL-CL-deBouganin

<400>  29
tctagagtcg acctgcaggt ctatggaacg ataaatgccc atgaaaattc tatttcaagg       60

agacagtcat aatgaaatac cttctgccga ccgctgccgc tggtctgctg ctgttggctg      120

ctcaaccggc tatggcagac atccagatga cccagtcccc gtctagcctg agcgcaagcg      180

ttggtgaccg tgtgaccatc acctgcaaaa gcactaaatc cctgctgcac tctaacggca      240

tcacctacct gtattggtac caacagaaac cgggttctgc tccgaaactg ctgatctacc      300

agatgtctca cctggctagc ggcgttcctt ctcgtttttc ttctagcggt agcggtactg      360

acttcaccct gaccattagc tctctgcagc ctgaagactt tgcgacctac tattgcgctc      420

agaaccttga aatcccgcgt accttcggcc agggtaccaa agttgaaatc aagcgtaccg      480

ttgcggctcc gtctgttttc atcttcccac ctagcgatga acagcttaaa tctggtactg      540

ctagcgtagt ttgcctgctt aacaacttct accctcgtga agctaaagtt cagtggaaag      600

ttgacaacgc tctgcagtct ggtaactctc aggaatctgt gaccgaacag gatagcaaag      660

atagcaccta tagcctgtct agcaccctga cccttagcaa ggcggactat gaaaaacaca      720

aagtttacgc ttgcgaggtg acccaccaag gtctgtcttc tccggtgact aaatccttta      780

accgtggcga atgcacccgt caccgtcagc cgcgtggttg ggaacagaaa tataacaccg      840

tatcttttaa cctgggtgag gcgtatgaat acccgacctt catccaggac ctgcgtaatg      900

aacttgctaa aggtacccct gtttgccagc tgcctgtgac cctgcagacc atcgctgatg      960

ataaacgttt cgttctggtt gacattacca ccacctccaa aaaaaccgtt aaagtcgcga     1020

tcgatgtgac cgacgtttac gtggtaggtt accaggataa atgggacggt aaagatcgtg     1080

cggttttcct ggacaaagtt ccgaccgtag cgacttctaa actgttccca ggtgtgacca     1140

accgtgtgac cctgaccttc gacggcagct atcagaaact ggttaacgcg gccaaagctg     1200

atcgtaaagc tctcgaactg ggtgttaaca aactggagtt cagcattgaa gctatccacg     1260

gtaaaaccat caacggtcaa gaagcagcta aattcttcct gatcgtgatc cagatggtta     1320

gcgaagcagc gcgttttaaa tacattgaaa ccgaagtagt tgatcgtggt ctgtatggta     1380

gcttcaaacc gaacttcaaa gttcttaacc tggagaacaa ctggggtgac attagcgacg     1440

cgatccataa atcttccccg caatgcacca ccattaaccc ggctctgcag ctgatctctc     1500

cgtctaacga tccgtgggta gttaacaaag tgtctcaaat cagcccggac atgggtatcc     1560

tgaaatttaa atctagcaaa tagtgactcg ag                                   1592


<210>  30
<211>  1598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of WT VL-CL-deBouganin

<400>  30
ctgcaggtct atggaacgat aaatgcccat gaaaattcta tttcaaggag acagtcataa       60

tgaaatacct attgcctacg gcagccgctg gattgttatt actcgctgcc caaccagcga      120

tggcgcacca tcatcaccat cacgatatcc agatgaccca gtccccgtcc tccctgagtg      180

cttctgttgg tgaccgtgtt accatcacct gccgttccac caaatccctc ctgcactcca      240

acggtatcac ctacctttat tggtatcaac agaaaccggg taaagctccg aaacttctga      300

tctaccagat gtccaacctg gcttccggtg ttccgtctcg tttctccagt tctggttctg      360

gtaccgactt caccctgacc atctcttctc tgcagccgga agacttcgct acctactact      420

gcgctcagaa cctggaaatc ccgcgtacct tcggtcaggg taccaaagtt gaacttaagc      480

gcactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg      540

gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt      600

ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca      660

gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga      720

aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga      780

gcttcaacag gggagagtgt acccgtcacc gtcagccgcg tggttgggaa cagctctata      840

acaccgtatc ttttaacctg ggtgaggcgt atgaataccc gaccttcatc caggacctgc      900

gtaatgaact tgctaaaggt acccctgttt gccagctgcc tgtgaccctg cagaccatcg      960

ctgatgataa acgtttcgtt ctggttgaca ttaccaccac ctccaaaaaa accgttaaag     1020

tcgcgatcga tgtgaccgac gtttacgtgg taggttacca ggataaatgg gacggtaaag     1080

atcgtgcggt tttcctggac aaagttccga ccgtagcgac ttctaaactg ttcccaggtg     1140

tgaccaaccg tgtgaccctg accttcgacg gcagctatca gaaactggtt aacgcggcca     1200

aagctgatcg taaagctctc gaactgggtg ttaacaaact ggagttcagc attgaagcta     1260

tccacggtaa aaccatcaac ggtcaagaag cagctaaatt cttcctgatc gtgatccaga     1320

tggttagcga agcagcgcgt tttaaataca ttgaaaccga agtagttgat cgtggtctgt     1380

atggtagctt caaaccgaac ttcaaagttc ttaacctgga gaacaactgg ggtgacatta     1440

gcgacgcgat ccataaatct tccccgcaat gcaccaccat taacccggct ctgcagctga     1500

tctctccgtc taacgatccg tgggtagtta acaaagtgtc tcaaatcagc ccggacatgg     1560

gtatcctgaa atttaaatct agcaaatagt gactcgag                             1598


<210>  31
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH (CDRsWT) -CH

<400>  31

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  32
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT + Treg) - CH

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  33
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deBouganin 2

<400>  33

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ser Ala Glu Val Asp Arg Lys Asp Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ile Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu His Gly Ser Phe Lys Pro Asp Phe Lys Val Leu 
            180                 185                 190         


Asp Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  34
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VH-CH-deBouganin 3

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  35
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VL-CL-deBouganin 3

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Thr Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  36
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH-CH-deBouganin 3

<400>  36

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Gln Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  37
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VL-CL-deBouganin 3

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser His Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  38
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT)-CH-deBouganin

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  39
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT)-CH-deBouganin3

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  40
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT + Treg)-CH-deBouganin

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  41
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT+Treg)-CH-deBouganin3

<400>  41

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  42
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deBouganin 3

<400>  42

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  43
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  deBouganin 4

<400>  43

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ala Ala Lys Val Asp Arg Lys Asp Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ile Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  44
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VH-CH-deBouganin 4

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  45
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DI VL-CL-deBouganin4

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Thr Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  46
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH-CH-deBouganin 4

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Gln Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  47
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VL-CL-deBouganin 4

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser His Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  48
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT)-CH-deBouganin4

<400>  48

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  49
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Algo VH(CDRsWT +Treg)-CH-deBouganin4

<400>  49

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Glu Phe Ser Leu Asp Thr His Asn Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  50
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VH-CH-deBouganin 3

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  51
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VH-CH-deBouganin4

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  52
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VL-CL-deBouganin 3

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


<210>  53
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VL-CL-deBouganin 4

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Arg His Arg Gln 
    210                 215                 220                 


Pro Arg Gly Trp Glu Gln Lys Tyr Asn Thr Val Ser Phe Asn Leu Gly 
225                 230                 235                 240 


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
                245                 250                 255     


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
            260                 265                 270         


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
        275                 280                 285             


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
    290                 295                 300                 


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
305                 310                 315                 320 


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
                325                 330                 335     


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val His Ala Ala 
            340                 345                 350         


Lys Val Asp Arg Lys Asp Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
        355                 360                 365             


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ile Ala 
    370                 375                 380                 


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
385                 390                 395                 400 


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
                405                 410                 415     


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
            420                 425                 430         


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
        435                 440                 445             


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
    450                 455                 460                 


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
465                 470                 475                 480 


Lys 
    


