                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Zlotnik, Albert
       Burkhardt, Amanda M
       Maravillasmontero, Jose L
 
<120>  IDENTIFICATION OF CXCR8, A NOVEL CHEMOKINE RECEPTOR

<130>  1279-588

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Val Phe Phe 
305                 310                 315                 320 


Arg Lys His Ile Thr Lys Arg Phe Cys Lys Gln Cys Pro Val Phe Tyr 
                325                 330                 335     


Arg Glu Thr Val Asp Gly Val Thr Ser Thr Asn Thr Pro Ser Thr Gly 
            340                 345                 350         


Glu Gln Glu Val Ser Ala Gly Leu 
        355                 360 


<210>  2
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  3
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  4
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  5
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  6
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu Thr Trp Pro 
1               5                   10                  15      


Pro Ala Ile Lys Leu Gly Phe Tyr Ala Tyr Leu Gly Val Leu Leu Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Asn Ser Leu Ala Leu Trp Val Phe Cys Cys Arg 
        35                  40                  45              


Met Gln Gln Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val 
    50                  55                  60                  


Ala Asp Leu Cys Leu Leu Cys Thr Leu Pro Phe Val Leu His Ser Leu 
65                  70                  75                  80  


Arg Asp Thr Ser Asp Thr Pro Leu Cys Gln Leu Ser Gln Gly Ile Tyr 
                85                  90                  95      


Leu Thr Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val 
            100                 105                 110         


Asp Arg Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Gly Leu Arg 
        115                 120                 125             


Ser Pro Arg Gln Ala Ala Ala Val Cys Ala Val Leu Trp Val Leu Val 
    130                 135                 140                 


Ile Gly Ser Leu Val Ala Arg Trp Leu Leu Gly Ile Gln Glu Gly Gly 
145                 150                 155                 160 


Phe Cys Phe Arg Ser Thr Arg His Asn Phe Asn Ser Met Ala Phe Pro 
                165                 170                 175     


Leu Leu Gly Phe Tyr Leu Pro Leu Ala Val Val Val Phe Cys Ser Leu 
            180                 185                 190         


Lys Val Val Thr Ala Leu Ala Gln Arg Pro Pro Thr Asp Val Gly Gln 
        195                 200                 205             


Ala Glu Ala Thr Arg Lys Ala Ala Arg Met Val Trp Ala Asn Leu Leu 
    210                 215                 220                 


Val Phe Val Val Cys Phe Leu Pro Leu His Val Gly Leu Thr Val Arg 
225                 230                 235                 240 


Leu Ala Val Gly Trp Asn Ala Cys Ala Leu Leu Glu Thr Ile Arg Arg 
                245                 250                 255     


Ala Leu Tyr Ile Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp 
            260                 265                 270         


Ala Ile Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Glu Ala Ser Ala 
        275                 280                 285             


Leu Ala Val Ala Pro Ser Ala Lys Ala His Lys Ser Gln Asp Ser Leu 
    290                 295                 300                 


Cys Val Thr Leu Ala 
305                 


<210>  7
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (27)..(27)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (45)..(45)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (49)..(49)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (57)..(57)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (60)..(60)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (63)..(63)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (75)..(75)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (81)..(81)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (91)..(91)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (95)..(95)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (105)..(105)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (109)..(109)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (111)..(111)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (113)..(113)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (138)..(138)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (148)..(148)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (152)..(152)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (154)..(154)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (157)..(158)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (167)..(167)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (174)..(174)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (180)..(181)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (185)..(185)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (195)..(197)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (221)..(222)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (244)..(244)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (251)..(251)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (255)..(255)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (263)..(264)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (268)..(269)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (283)..(283)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (289)..(289)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (303)..(303)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (306)..(306)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (315)..(315)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (320)..(320)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (325)..(325)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (328)..(328)
<223>  conserved residue

<220>
<221>  Xaa
<222>  (334)..(335)
<223>  conserved residues

<220>
<221>  Xaa
<222>  (344)..(344)
<223>  conserved residue

<400>  7

Met Pro Thr Asn Glu Asp Tyr Xaa Glu Xaa Thr Phe Asp Xaa Asp Tyr 
1               5                   10                  15      


Glu Pro Cys Gln Lys Ser Asp Val Lys Gln Xaa Gly Ala Leu Gln Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Xaa Gly Xaa Val Gly Asn 
        35                  40                  45              


Xaa Leu Val Val Leu Val Leu Ile Xaa Cys Lys Xaa Leu Lys Xaa Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Xaa Cys Leu Leu Phe Leu 
65                  70                  75                  80  


Xaa Thr Leu Pro Phe Trp Ala His Ser Ala Xaa Ala Asn Trp Xaa Phe 
                85                  90                  95      


Gly Asn Ala Met Cys Lys Leu Leu Xaa Gly Ile Tyr Xaa Ile Xaa Leu 
            100                 105                 110         


Xaa Ser Ser Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Ala Val Phe Ala Leu Xaa Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Xaa Ser Val Ile Xaa Trp Xaa Leu Ala Xaa Xaa Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Xaa Lys Thr Gln Lys Glu Asp Xaa His Tyr 
                165                 170                 175     


Thr Cys Ser Xaa Xaa Phe Pro His Xaa Glu Trp Lys Asn Phe Gln Thr 
            180                 185                 190         


Leu Lys Xaa Xaa Xaa Leu Gly Leu Val Leu Pro Leu Leu Val Met Val 
        195                 200                 205             


Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Xaa Xaa Asn Glu 
    210                 215                 220                 


Lys Lys Arg His Lys Ala Val Arg Leu Ile Phe Thr Ile Met Ile Val 
225                 230                 235                 240 


Phe Phe Leu Xaa Trp Leu Pro Tyr Asn Ile Xaa Ile Leu Leu Xaa Thr 
                245                 250                 255     


Phe Gln Glu Phe Phe Gly Xaa Xaa Asn Cys Glu Xaa Xaa Asn Thr Leu 
            260                 265                 270         


Asp Gln Ala Leu Gln Val Thr Glu Thr Leu Xaa Met Thr His Cys Cys 
        275                 280                 285             


Xaa Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe Arg Xaa Tyr 
    290                 295                 300                 


Leu Xaa Val Phe Phe His Lys His Ile Ala Xaa Arg Phe Cys Lys Xaa 
305                 310                 315                 320 


Pro Ile Phe Ser Xaa Glu Ala Xaa Glu Gly Val Ser Ser Xaa Xaa Thr 
                325                 330                 335     


Pro Ser Thr Gly Glu Gln Glu Xaa Ser Ala Gly Leu 
            340                 345             


<210>  8
<211>  323
<212>  PRT
<213>  Felis catus

<400>  8

Met Ser Arg Gly Gly Gly Asp Gly Ser Ala Gln Arg Glu Lys Pro Gln 
1               5                   10                  15      


Gly Arg Gly Val Gly Ser Leu Pro His Cys Ala Arg Arg Ala Gly Leu 
            20                  25                  30          


Ser Gly Arg Lys Thr Arg Arg Leu Gly Val Ser Ser Glu Trp Gly Gly 
        35                  40                  45              


Arg Pro Arg Arg Pro Leu Glu Gln Gly Cys Pro Cys Ala Gln Ser His 
    50                  55                  60                  


Arg Lys Ser Pro Val Trp Val Arg Thr Ala Gly Pro Glu Glu Pro Leu 
65                  70                  75                  80  


Cys Pro Arg Thr Ser Arg Arg Thr Met Asn Gly Thr Cys His Ser Ser 
                85                  90                  95      


Glu Leu Thr Trp Pro Tyr Trp Val Lys Asn Ile Val Asp Ala Tyr Val 
            100                 105                 110         


Gly Leu Leu Leu Ala Leu Gly Leu Leu Leu Asn Gly Leu Ala Leu Trp 
        115                 120                 125             


Val Phe Cys Cys Arg Val Arg Arg Trp Thr Glu Thr His Ile Tyr Met 
    130                 135                 140                 


Ala Asn Leu Ala Val Ala Asp Leu Cys Leu Leu Cys Ala Leu Pro Phe 
145                 150                 155                 160 


Phe Leu Tyr Ser Leu Lys Gln Arg Gly Val Arg Glu Gly Gly Phe Cys 
                165                 170                 175     


Phe Leu Ser Ala Ser Arg His Ser Ser Asn Thr Thr Ala Phe Ser Leu 
            180                 185                 190         


Leu Gly Phe Tyr Leu Pro Leu Ala Val Leu Leu Phe Cys Ser Leu Arg 
        195                 200                 205             


Val Val Ala Ala Leu Gly Gln Gly Pro Ala Ala His Thr Asp Gln Ala 
    210                 215                 220                 


Glu Ala Thr Arg Arg Ala Thr Arg Met Val Trp Ala Asn Leu Val Val 
225                 230                 235                 240 


Phe Val Ala Cys Phe Leu Pro Leu His Val Val Leu Ala Val His Val 
                245                 250                 255     


Ala Ala Ser Arg Ser Ala Pro Ala Pro Ala Leu Cys Tyr Ala Leu Tyr 
            260                 265                 270         


Val Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp Ala Ile Cys 
        275                 280                 285             


Tyr Tyr Phe Met Ala Lys Glu Phe Gln Glu Glu Ala Ala Ala Leu Ala 
    290                 295                 300                 


Ser Met Pro Thr Ala Lys Ala His Arg Ser Arg Asp Ser Phe Ser Val 
305                 310                 315                 320 


Thr Leu Ala 
            


<210>  9
<211>  379
<212>  PRT
<213>  Bos taurus

<400>  9

Met Pro Thr Ser Cys Ser Ile Ala Ser Thr Ile Phe Ser Gln Thr Pro 
1               5                   10                  15      


Thr Ile Pro Arg Gly Glu Gly Pro Arg Pro Gln Gly Arg Arg Ser Pro 
            20                  25                  30          


Cys Leu Gln Ser Arg Ile Trp Thr Pro Thr Arg His Arg Leu Pro His 
        35                  40                  45              


Arg Leu Leu Gly Arg Cys Glu Ala Gly Glu Pro Phe Gly Arg Thr Cys 
    50                  55                  60                  


Arg Gly Val Ser Ser Ser Gly Gly Asn Gln Arg Val Ser Pro Gly Ile 
65                  70                  75                  80  


Met Asn Ser Ser Asn Cys Ser Ser Trp Asp Ala Asn Pro Val Tyr Tyr 
                85                  90                  95      


Thr Tyr Met Gly Gly Leu Leu Ala Leu Gly Leu Leu Leu Asn Gly Leu 
            100                 105                 110         


Ala Leu Trp Val Leu Cys Trp Arg Leu Pro Arg Trp Thr Glu Thr Arg 
        115                 120                 125             


Ile Tyr Met Ala Asn Leu Ala Val Ala Asp Leu Cys Leu Leu Cys Ala 
    130                 135                 140                 


Leu Pro Ser Phe Leu Tyr Phe Gln Lys Gln Thr Ser Lys Asp Thr Pro 
145                 150                 155                 160 


Leu Cys Gln Ile Ser Gln Ala Val Tyr Leu Leu Asn Arg Tyr Met Ser 
                165                 170                 175     


Ile Ser Leu Val Thr Ala Ile Ala Val Asp Arg Tyr Val Ala Val Arg 
            180                 185                 190         


His Pro Leu Arg Ala Arg Arg Leu Arg Ser Pro Gly Arg Ala Ala Ala 
        195                 200                 205             


Val Cys Thr Ala Leu Trp Ala Val Val Leu Gly Ser Leu Val Leu Arg 
    210                 215                 220                 


Trp Phe Leu Asp Val Gln Asp Gly Gly Phe Cys Phe Ala Val Arg Ser 
225                 230                 235                 240 


Gly Arg Ser Thr Tyr Thr Gly Val Phe Ser Leu Leu Gly Phe Tyr Leu 
                245                 250                 255     


Pro Leu Ala Val Leu Val Phe Cys Ser Leu Gln Val Val Thr Ala Leu 
            260                 265                 270         


Thr Gln Arg Pro Glu Ala Asn Pro Gly Gln Ala Glu Ala Thr Gln Lys 
        275                 280                 285             


Ala Ser Arg Met Val Leu Ala Asn Leu Ala Val Phe Val Val Cys Phe 
    290                 295                 300                 


Leu Pro Phe His Met Val Leu Thr Met Arg Val Ala Leu Gly Leu Gln 
305                 310                 315                 320 


Thr Cys Ala Ile Lys Val Ala Met Gln Ile Thr Ser Arg Leu Ser Asp 
                325                 330                 335     


Ala Asn Cys Cys Leu Asp Ala Ile Cys Tyr Tyr Phe Met Ala Lys Glu 
            340                 345                 350         


Phe Gln Glu Ala Ser Val Ser Thr Thr Ser Pro Arg Ala Lys Ala His 
        355                 360                 365             


Lys Ser Lys Asp Ser Val Thr Met Thr Leu Thr 
    370                 375                 


<210>  10
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ser Gly Ser Arg Ala Val Pro Thr Pro His Arg Gly Ser Glu 
1               5                   10                  15      


Glu Leu Leu Lys Tyr Met Leu His Ser Pro Cys Val Ser Leu Thr Met 
            20                  25                  30          


Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu Thr Trp Pro Pro 
        35                  40                  45              


Ala Ile Lys Leu Gly Phe Tyr Ala Tyr Leu Gly Val Leu Leu Val Leu 
    50                  55                  60                  


Gly Leu Leu Leu Asn Ser Leu Ala Leu Trp Val Phe Cys Cys Arg Met 
65                  70                  75                  80  


Gln Gln Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Cys Leu Leu Cys Thr Leu Pro Phe Val Leu His Ser Leu Arg 
            100                 105                 110         


Asp Thr Ser Asp Thr Pro Leu Cys Gln Leu Ser Gln Gly Ile Tyr Leu 
        115                 120                 125             


Thr Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val Asp 
    130                 135                 140                 


Arg Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Gly Leu Arg Ser 
145                 150                 155                 160 


Pro Arg Gln Ala Ala Ala Val Cys Ala Val Leu Trp Val Leu Val Ile 
                165                 170                 175     


Gly Ser Leu Val Ala Arg Trp Leu Leu Gly Ile Gln Glu Gly Gly Phe 
            180                 185                 190         


Cys Phe Arg Ser Thr Arg His Asn Phe Asn Ser Met Ala Phe Pro Leu 
        195                 200                 205             


Leu Gly Phe Tyr Leu Pro Leu Ala Val Val Val Phe Cys Ser Leu Lys 
    210                 215                 220                 


Val Val Thr Ala Leu Ala Gln Arg Pro Pro Thr Asp Val Gly Gln Ala 
225                 230                 235                 240 


Glu Ala Thr Arg Lys Ala Ala Arg Met Val Trp Ala Asn Leu Leu Val 
                245                 250                 255     


Phe Val Val Cys Phe Leu Pro Leu His Val Gly Leu Thr Val Arg Leu 
            260                 265                 270         


Ala Val Gly Trp Asn Ala Cys Ala Leu Leu Glu Thr Ile Arg Arg Ala 
        275                 280                 285             


Leu Tyr Ile Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp Ala 
    290                 295                 300                 


Ile Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Glu Ala Ser Ala Leu 
305                 310                 315                 320 


Ala Val Ala Pro Ser Ala Lys Ala His Lys Ser Gln Asp Ser Leu Cys 
                325                 330                 335     


Val Thr Leu Ala 
            340 


<210>  11
<211>  300
<212>  PRT
<213>  Pan troglodytes

<400>  11

Met Leu Cys Leu Arg Cys Phe Val Phe Val Asp Met Gly Leu Gly Leu 
1               5                   10                  15      


Thr Ser Ser His Ile Pro Ala Gln Arg Trp Ala Glu Trp Gly Gln Cys 
            20                  25                  30          


Leu Ala Pro Pro Ala Arg Ser Leu Leu Thr Ser Gly Ser Leu Cys Cys 
        35                  40                  45              


Pro Arg Thr Met Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu 
    50                  55                  60                  


Thr Trp Pro Pro His Ser Leu Arg Asp Thr Ser Asp Thr Pro Leu Cys 
65                  70                  75                  80  


Gln Leu Ser Gln Gly Ile Tyr Leu Thr Asn Arg Tyr Met Ser Ile Ser 
                85                  90                  95      


Leu Val Thr Ala Ile Ala Val Asp Arg Tyr Val Ala Val Arg His Pro 
            100                 105                 110         


Leu Arg Ala Arg Gly Leu Arg Ser Pro Arg Gln Ala Ala Ala Val Cys 
        115                 120                 125             


Ala Val Leu Trp Val Leu Val Ile Gly Ser Leu Val Ala Arg Trp Phe 
    130                 135                 140                 


Leu Gly Met Gln Glu Gly Gly Phe Cys Phe Arg Ser Thr Arg His Asn 
145                 150                 155                 160 


Phe Asn Ser Met Ala Phe Pro Leu Leu Gly Phe Tyr Leu Pro Leu Ala 
                165                 170                 175     


Val Val Val Phe Cys Ser Leu Lys Val Val Thr Ala Leu Ala Gln Arg 
            180                 185                 190         


Pro Pro Thr Asp Val Gly Gln Ala Glu Ala Thr Arg Lys Ala Ala Arg 
        195                 200                 205             


Met Val Trp Ala Asn Leu Val Val Phe Val Val Cys Phe Leu Pro Leu 
    210                 215                 220                 


His Val Gly Leu Thr Val Arg Leu Ala Val Gly Trp Asn Ala Cys Ala 
225                 230                 235                 240 


Leu Leu Glu Thr Val Arg Arg Ala Leu Tyr Ile Thr Ser Lys Leu Ser 
                245                 250                 255     


Asp Ala Asn Cys Cys Leu Asp Ala Ile Cys Tyr Tyr Tyr Met Ala Lys 
            260                 265                 270         


Glu Phe Gln Glu Ala Ser Ala Leu Ala Val Ala Pro Ser Ala Lys Ala 
        275                 280                 285             


His Lys Ser Gln Asp Ser Leu Cys Val Thr Leu Ala 
    290                 295                 300 


<210>  12
<211>  309
<212>  PRT
<213>  Macaca mulatta

<400>  12

Met Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu Thr Trp Pro 
1               5                   10                  15      


Pro Thr Ile Lys Leu Gly Phe Tyr Ala Tyr Leu Gly Ile Leu Leu Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Asn Ser Leu Ala Leu Trp Val Phe Cys Cys Arg 
        35                  40                  45              


Met Gln Arg Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val 
    50                  55                  60                  


Ala Asp Leu Cys Leu Leu Cys Ala Leu Pro Phe Val Leu His Ser Leu 
65                  70                  75                  80  


Gln Asp Thr Ser Asp Thr Pro Leu Cys Gln Leu Ser Gln Gly Ile Tyr 
                85                  90                  95      


Leu Thr Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val 
            100                 105                 110         


Asp Arg Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Gly Leu Arg 
        115                 120                 125             


Ser Pro Arg Gln Ala Ala Ala Val Cys Ala Val Leu Trp Met Leu Val 
    130                 135                 140                 


Ile Gly Ser Leu Val Ala Arg Trp Phe Leu Gly Met Gln Glu Gly Gly 
145                 150                 155                 160 


Phe Cys Phe Arg Ser Thr Arg His Asn Phe Ser Ser Met Ala Phe Pro 
                165                 170                 175     


Leu Leu Gly Phe Tyr Leu Pro Leu Ala Val Val Val Phe Cys Ser Leu 
            180                 185                 190         


Lys Val Val Thr Ala Leu Ala Gln Arg Pro Pro Ile Asp Val Gly Gln 
        195                 200                 205             


Ala Glu Ala Ser His Lys Ala Ala Arg Met Val Trp Ala Asn Leu Val 
    210                 215                 220                 


Val Phe Val Val Cys Phe Leu Pro Leu His Val Gly Leu Thr Val Arg 
225                 230                 235                 240 


Leu Thr Val Gly Trp Asn Ala Cys Ala Phe Leu Glu Thr Leu Arg Arg 
                245                 250                 255     


Thr Leu Phe Ile Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp 
            260                 265                 270         


Ala Ile Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Glu Ala Ser Ala 
        275                 280                 285             


Leu Ala Val Val Pro Ser Ala Lys Ala His Lys Ser Gln Ala Ser Leu 
    290                 295                 300                 


Cys Val Thr Leu Ala 
305                 


<210>  13
<211>  306
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Asn Asn Thr Asn Cys Ser Ile Leu Pro Trp Pro Ala Ala Val Asn 
1               5                   10                  15      


His Ile Phe Thr Ile Tyr Leu Val Leu Leu Leu Val Leu Gly Leu Leu 
            20                  25                  30          


Leu Asn Gly Leu Ala Leu Trp Val Phe Cys Tyr Arg Met His Gln Trp 
        35                  40                  45              


Thr Glu Thr Arg Val Tyr Met Thr Asn Leu Ala Val Ala Asp Val Cys 
    50                  55                  60                  


Leu Leu Cys Ser Leu Pro Phe Val Leu Tyr Ser Leu Lys Tyr Ser Thr 
65                  70                  75                  80  


Ser Asp Thr Pro Ile Cys Gln Leu Ser Gln Gly Ile Tyr Leu Val Asn 
                85                  90                  95      


Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val Asp Arg Tyr 
            100                 105                 110         


Val Ala Val Arg His Pro Leu Arg Ala Arg Glu Leu Arg Ser Pro Arg 
        115                 120                 125             


Gln Ala Gly Ala Val Cys Val Ala Leu Trp Val Ile Val Val Thr Ser 
    130                 135                 140                 


Leu Val Leu Arg Trp Arg Leu Gly Ile Gln Glu Gly Gly Phe Cys Phe 
145                 150                 155                 160 


Ser Ser Gln Asn Arg Tyr Asn Phe Ser Thr Thr Ala Phe Ser Leu Leu 
                165                 170                 175     


Gly Phe Tyr Leu Pro Leu Ala Ile Val Val Phe Cys Ser Leu Gln Val 
            180                 185                 190         


Val Thr Ala Leu Ala Arg Arg Pro Ala Thr Asp Val Glu Gln Val Glu 
        195                 200                 205             


Ala Thr Gln Lys Ala Thr Arg Met Val Trp Ala Asn Leu Ala Val Phe 
    210                 215                 220                 


Ile Ile Cys Phe Leu Pro Leu His Leu Ile Leu Thr Val Gln Val Ser 
225                 230                 235                 240 


Leu Asn Leu His Thr Cys Ala Ala Arg Asn Ile Phe Ser Arg Ala Leu 
                245                 250                 255     


Thr Ile Thr Ala Lys Leu Ser Asp Ile Asn Cys Cys Leu Asp Ala Ile 
            260                 265                 270         


Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Asp Ala Ser Leu Arg Ala 
        275                 280                 285             


Thr Ala Ser Ser Thr Pro His Lys Ser Gln Asp Thr Gln Ser Leu Ser 
    290                 295                 300                 


Leu Thr 
305     


<210>  14
<211>  307
<212>  PRT
<213>  Mus musculus

<400>  14

Met Asn Ser Thr Thr Cys Asn Ser Thr Leu Thr Trp Pro Ala Ser Val 
1               5                   10                  15      


Asn Asn Phe Phe Ile Ile Tyr Ser Ala Leu Leu Leu Val Leu Gly Leu 
            20                  25                  30          


Leu Leu Asn Ser Val Ala Leu Trp Val Phe Cys Tyr Arg Met His Gln 
        35                  40                  45              


Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val Ala Asp Leu 
    50                  55                  60                  


Cys Leu Leu Cys Ser Leu Pro Phe Val Leu Tyr Ser Leu Lys Tyr Ser 
65                  70                  75                  80  


Ser Ser Asp Thr Pro Val Cys Gln Leu Ser Gln Gly Ile Tyr Leu Ala 
                85                  90                  95      


Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val Asp Arg 
            100                 105                 110         


Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Glu Leu Arg Ser Pro 
        115                 120                 125             


Arg Gln Ala Ala Ala Val Cys Val Ala Leu Trp Val Ile Val Val Thr 
    130                 135                 140                 


Ser Leu Val Val Arg Trp Arg Leu Gly Met Gln Glu Gly Gly Phe Cys 
145                 150                 155                 160 


Phe Ser Ser Gln Thr Arg Arg Asn Phe Ser Thr Thr Ala Phe Ser Leu 
                165                 170                 175     


Leu Gly Phe Tyr Leu Pro Leu Ala Ile Val Val Phe Cys Ser Leu Gln 
            180                 185                 190         


Val Val Thr Val Leu Ser Arg Arg Pro Ala Ala Asp Val Gly Gln Ala 
        195                 200                 205             


Glu Ala Thr Gln Lys Ala Thr His Met Val Trp Ala Asn Leu Ala Val 
    210                 215                 220                 


Phe Val Ile Cys Phe Leu Pro Leu His Val Val Leu Thr Val Gln Val 
225                 230                 235                 240 


Ser Leu Asn Leu Asn Thr Cys Ala Ala Arg Asp Thr Phe Ser Arg Ala 
                245                 250                 255     


Leu Ser Ile Thr Gly Lys Leu Ser Asp Thr Asn Cys Cys Leu Asp Ala 
            260                 265                 270         


Ile Cys Tyr Tyr Tyr Met Ala Arg Glu Phe Gln Glu Ala Ser Lys Pro 
        275                 280                 285             


Ala Thr Ser Ser Asn Thr Pro His Lys Ser Gln Asp Ser Gln Ile Leu 
    290                 295                 300                 


Ser Leu Thr 
305         


<210>  15
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  15

Met Lys Leu Leu Ala Ser Pro Phe Leu Leu Leu Leu Pro Val Met Leu 
1               5                   10                  15      


Met Ser Met Val Phe Ser Ser Pro Asn Pro Gly Val Ala Arg Ser His 
            20                  25                  30          


Gly Asp Gln His Leu Ala Pro Arg Arg Trp Leu Leu Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Gln Ala Pro Lys Arg Lys Ala 
    50                  55                  60                  


Thr Ala Val Leu Gly Pro Pro Arg Lys Gln Cys Pro Cys Asp His Val 
65                  70                  75                  80  


Lys Gly Arg Glu Lys Lys Asn Arg His Gln Lys His His Arg Lys Ser 
                85                  90                  95      


Gln Arg Pro Ser Arg Ala Cys Gln Gln Phe Leu Lys Arg Cys His Leu 
            100                 105                 110         


Ala Ser Phe Ala Leu Pro Leu 
        115                 


<210>  16
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Lys Leu Leu Ala Ser Pro Phe Leu Leu Leu Leu Thr Gly Met Phe 
1               5                   10                  15      


Thr Ala Thr Val Ser Ser Ser Pro Asn Gln Glu Val Ala Arg His His 
            20                  25                  30          


Gly Asp Gln His Gln Ala Pro Arg Arg Trp Leu Trp Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Asp Cys Lys Asp Trp Ser Leu Arg Val Ser Lys Arg Lys Thr 
    50                  55                  60                  


Thr Ala Val Leu Glu Pro Pro Arg Lys Gln Cys Pro Cys Asp His Val 
65                  70                  75                  80  


Lys Gly Ser Glu Lys Lys Asn Arg Arg Gln Lys His His Arg Lys Ser 
                85                  90                  95      


Gln Arg Pro Ser Arg Thr Cys Gln Gln Phe Leu Lys Arg Cys Gln Leu 
            100                 105                 110         


Ala Ser Phe Thr Leu Pro Leu 
        115                 


<210>  17
<211>  118
<212>  PRT
<213>  Bos taurus

<400>  17

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Val Val Ser Ser Ser Ser His Thr Gly Val Ala Arg Gly Gln 
            20                  25                  30          


Arg Asp Gln Arg Gln Ala Ser Gly Arg Trp Leu Arg Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Gln Asp Trp Phe Leu Arg Ala Pro Arg Arg Thr Leu 
    50                  55                  60                  


Met Ala Ala Pro Arg Leu Thr Lys Pro Cys Pro Cys Asp His Phe Lys 
65                  70                  75                  80  


Gly Arg Met Lys Lys Thr Arg His Gln Arg His His Arg Lys Ser Asn 
                85                  90                  95      


Lys Pro Ser Arg Ala Cys Gln Gln Phe Leu Thr Arg Cys Leu Leu Glu 
            100                 105                 110         


Ser Phe Ala Leu Pro Leu 
        115             


<210>  18
<211>  119
<212>  PRT
<213>  Felis catus

<400>  18

Met Arg Ile Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Pro Met Val Ser Ser Ser Arg Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Gln Arg Gln Ala Pro Arg Arg Trp Leu Gln Glu Gly Ser Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Lys Arg Lys Leu 
    50                  55                  60                  


Met Thr Val Pro Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Ser Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Thr Arg Cys Gln Leu 
            100                 105                 110         


Glu Ser Phe Ala Leu Pro Leu 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  Macaca mulatta

<400>  19

Met Lys Val Leu Ile Ser Ser Phe Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Gln Gly Gln Ala Ser Arg Lys Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Val 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Lys His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Val Leu Pro Leu 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Phe 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Ala Leu Pro Leu 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  Pan troglodytes

<400>  21

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Lys Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Leu 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Ala Leu Pro Leu 
        115                 


