                         SEQUENCE LISTING

<110>  Los Alamos National Security, LLC
       Duke University
       Dana-Farber Cancer Institute
       Korber, Bette T.M.
       Gnanakaran, S.
       Perkins, Simon
       Sodroski, Joseph
       Haynes, Barton
 
<120>  MOSAIC HIV ENVELOPE IMMUNOGENIC POLYPEPTIDES

<130>  8472-91895-02

<150>  US 61/884,696
<151>  2013-09-30

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cmos3.1 mosaic protein

<400>  1

Met Arg Val Arg Gly Ile Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Ser Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Thr Ala Thr Asn Thr Thr Thr Arg Asn Asn Thr Val Gly 
    130                 135                 140                 


Glu Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Lys Lys Lys Asn Val Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val Pro 
                165                 170                 175     


Leu His Glu Lys Asp Asn Asn Ile Ser Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Lys Glu Pro Val Glu 
        275                 280                 285             


Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Val Ser Lys Gln Asn Trp Asn Arg Thr Leu 
                325                 330                 335     


Gln Gln Val Gly Arg Lys Leu Ala Glu His Phe Pro Asn Arg Asn Ile 
            340                 345                 350         


Thr Phe Asn His Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Gly Thr Tyr His Pro Asn Gly Thr Tyr Asn Glu Thr Ala Val Asn 
385                 390                 395                 400 


Ser Ser Asp Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly 
            420                 425                 430         


Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Lys Asn Asn Ser Gly Pro Glu Thr Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     


Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly 
            500                 505                 510         


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu 
        515                 520                 525             


Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg 
                565                 570                 575     


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys 
        595                 600                 605             


Ser Gln Gly Glu Ile Trp Gly Asn Met Thr Trp Met Gln Trp Asp Arg 
    610                 615                 620                 


Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser 
625                 630                 635                 640 


Gln Ile Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser 
                645                 650                 655     


Trp Lys Asn Leu Trp Ser Trp Phe Ser Ile Thr Asn Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
        675                 680                 685             


Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg 
705                 710                 715                 720 


Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser 
                725                 730                 735     


Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
            740                 745                 750         


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile 
        755                 760                 765             


Ala Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu 
    770                 775                 780                 


Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr 
785                 790                 795                 800 


Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile 
                805                 810                 815     


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Val Gln 
            820                 825                 830         


Arg Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Phe Glu Ala Ala Leu Gln 
    850                 


<210>  2
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cmos3.2 mosaic protein

<400>  2

Met Arg Val Met Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Ser Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Glu Val Ala Lys Ala Thr Gly Asn Phe Thr Gly Val Glu 
    130                 135                 140                 


Met Lys Asn Cys Ser Phe Asn Thr Thr Thr Glu Leu Arg Asp Lys Lys 
145                 150                 155                 160 


Glu Asn Gln Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Ser 
                165                 170                 175     


Lys Lys Asp Lys Thr Asn Asn Asp Ser Gly Glu Tyr Ile Leu Ile Asn 
            180                 185                 190         


Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Asp 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Tyr Ala Ile Leu Lys 
    210                 215                 220                 


Cys Lys Asp Lys Thr Phe Asn Gly Thr Gly Pro Cys Arg Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu 
            260                 265                 270         


Asn Leu Thr Asp Asn Val Lys Thr Ile Ile Val His Leu Asn Glu Ser 
        275                 280                 285             


Val Glu Ile Val Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys Ser Val 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Asp Ile Arg Glu Ala His Cys Asn Ile Ser Arg Trp Ser Glu Thr Leu 
                325                 330                 335     


Glu Lys Val Arg Glu Lys Leu Lys Gly Leu Phe Asn Lys Thr Ile Glu 
            340                 345                 350         


Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe 
        355                 360                 365             


Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Trp Ser 
    370                 375                 380                 


Asn Glu Ser Asn Asp Gly Asn Asp Thr Ile Ile Leu Pro Cys Arg Ile 
385                 390                 395                 400 


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala 
                405                 410                 415     


Pro Pro Ile Ala Gly Ser Ile Thr Cys Lys Ser Ser Ile Thr Gly Leu 
            420                 425                 430         


Leu Leu Val Arg Asp Gly Gly Ile Thr Asn Asn Asn Thr Glu Thr Phe 
        435                 440                 445             


Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr 
    450                 455                 460                 


Lys Tyr Lys Val Val Glu Ile Gln Pro Leu Gly Val Ala Pro Thr Gly 
465                 470                 475                 480 


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly 
                485                 490                 495     


Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
            500                 505                 510         


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
        515                 520                 525             


Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His 
    530                 535                 540                 


Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val 
545                 550                 555                 560 


Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp 
                565                 570                 575     


Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser 
            580                 585                 590         


Ser Trp Ser Asn Lys Ser Gln Thr Asp Ile Trp Asp Asn Met Thr Trp 
        595                 600                 605             


Ile Gln Trp Asp Arg Glu Ile Ser Asn Tyr Ser Asn Thr Ile Tyr Lys 
    610                 615                 620                 


Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Gln Asn Glu Lys Asp Leu 
625                 630                 635                 640 


Leu Ala Leu Asp Ser Trp Asn Asn Leu Trp Asn Trp Phe Asp Ile Thr 
                645                 650                 655     


Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly Leu 
            660                 665                 670         


Ile Gly Leu Arg Ile Ile Leu Gly Val Leu Ser Ile Val Lys Arg Val 
        675                 680                 685             


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro 
    690                 695                 700                 


Arg Gly Leu Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln 
705                 710                 715                 720 


Asp Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala 
                725                 730                 735     


Trp Glu Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Gln Leu Arg 
            740                 745                 750         


Asp Phe Ile Leu Ile Val Ala Arg Ala Val Glu Leu Leu Gly Arg Ser 
        755                 760                 765             


Ser Leu Arg Gly Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu Gly 
    770                 775                 780                 


Asn Leu Val Gln Tyr Trp Gly Leu Glu Ile Lys Lys Ser Ala Ile Asn 
785                 790                 795                 800 


Leu Leu Asp Thr Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile 
                805                 810                 815     


Ile Glu Leu Ile Gln Arg Ile Cys Arg Ala Ile Cys Asn Ile Pro Thr 
            820                 825                 830         


Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
        835                 840             


<210>  3
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cmos3.3 mosaic protein

<400>  3

Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Gly Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Ala Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Gln Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Ser Asn Arg Thr Val Asp Asn Ala Thr Gln 
    130                 135                 140                 


Gly Glu Met Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp 
145                 150                 155                 160 


Lys Lys Arg Gln Val Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val Pro 
                165                 170                 175     


Ile Asn Glu Ser Ser Ser Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Ala Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Gln Glu Ile Val Ile Arg Ser Glu Asn Leu 
            260                 265                 270         


Thr Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Thr Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Ala Phe Tyr Ala Thr Asn Gly Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Arg Glu Leu Trp Asn Lys Thr Leu 
                325                 330                 335     


Glu Gly Val Arg Glu Lys Leu Lys Glu His Phe Pro Asn Arg Thr Ile 
            340                 345                 350         


Asn Phe Asn Gln Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Lys Asn Asn Leu Thr Ala Ser Asn Thr Glu Ser Asn Gln Thr Ile Thr 
385                 390                 395                 400 


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly Val Gly 
                405                 410                 415     


Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser 
            420                 425                 430         


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Thr Asn Asp Ser 
        435                 440                 445             


Met Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp 
    450                 455                 460                 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
465                 470                 475                 480 


Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
                485                 490                 495     


Ala Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
            500                 505                 510         


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
        515                 520                 525             


Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
    530                 535                 540                 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
545                 550                 555                 560 


Leu Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu Gln Asp Gln Gln 
                565                 570                 575     


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn 
            580                 585                 590         


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Gln Asp Glu Ile Trp 
        595                 600                 605             


Gly Asn Met Thr Trp Met Gln Trp Glu Lys Glu Ile Ser Asn Tyr Thr 
    610                 615                 620                 


Asp Thr Ile Tyr Arg Leu Leu Glu Glu Ser Gln Thr Gln Gln Glu Gln 
625                 630                 635                 640 


Asn Glu Lys Asp Leu Leu Ala Leu Asp Lys Trp Gln Asn Leu Trp Ser 
                645                 650                 655     


Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
            660                 665                 670         


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
        675                 680                 685             


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
    690                 695                 700                 


Leu Ile Pro Ser Pro Arg Gly Pro Asp Arg Leu Gly Gly Ile Glu Glu 
705                 710                 715                 720 


Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Ser Gly 
                725                 730                 735     


Phe Leu Ser Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys 
            740                 745                 750         


Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Ala Ala Glu 
        755                 760                 765             


Leu Leu Gly Arg Ser Ser Leu Lys Gly Leu Gln Arg Gly Trp Glu Ile 
    770                 775                 780                 


Leu Lys Tyr Leu Gly Asn Leu Leu Gln Tyr Trp Gly Leu Glu Leu Lys 
785                 790                 795                 800 


Arg Ser Ala Ile Ser Leu Leu Asp Thr Thr Ala Ile Thr Val Ala Glu 
                805                 810                 815     


Gly Thr Asp Arg Ile Ile Glu Ile Val Gln Arg Ile Cys Arg Ala Ile 
            820                 825                 830         


Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Thr Ala Leu Leu 
        835                 840                 845             


<210>  4
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bmos3.1 mosaic protein

<400>  4

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Ser Ser Asn Ser Thr Ser Val Asn Ile Thr Ser 
    130                 135                 140                 


Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile 
145                 150                 155                 160 


Arg Gly Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Ile 
                165                 170                 175     


Val Pro Ile Asp Asn Asp Asn Arg Asn Asn Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
            260                 265                 270         


Asn Phe Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu Ser 
        275                 280                 285             


Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


His Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Glu Ile Ile Gly 
305                 310                 315                 320 


Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Thr His Trp Asn Asn 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Arg Asn Asp Thr Trp Asn Asp Thr Trp 
385                 390                 395                 400 


Lys Asp Thr Thr Asn Asp Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Asn Ser Ser Ser Asn Asn Glu Thr Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Met 
            500                 505                 510         


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
        515                 520                 525             


Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
    530                 535                 540                 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
545                 550                 555                 560 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                565                 570                 575     


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
            580                 585                 590         


Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp 
        595                 600                 605             


Ser Asn Lys Ser Leu Asp Ala Ile Trp Asn Asn Met Thr Trp Met Glu 
    610                 615                 620                 


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile 
625                 630                 635                 640 


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
                645                 650                 655     


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp 
            660                 665                 670         


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
        675                 680                 685             


Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln 
    690                 695                 700                 


Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ala Pro Arg Gly 
705                 710                 715                 720 


Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg 
                725                 730                 735     


Asp Arg Ser Gly Pro Leu Val Asp Gly Phe Leu Ala Ile Ile Trp Val 
            740                 745                 750         


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu 
        755                 760                 765             


Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp 
    770                 775                 780                 


Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu 
785                 790                 795                 800 


Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val 
                805                 810                 815     


Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Leu Gln Arg Ile Gly Arg 
            820                 825                 830         


Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala 
        835                 840                 845             


Leu Leu 
    850 


<210>  5
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRF01mos3.1 mosaic protein

<400>  5

Met Arg Val Arg Gly Ile Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asn Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Met Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Pro Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Glu Trp His Asn Thr Thr Asn Gly Asn Ser Ser 
    130                 135                 140                 


Ile Gly Asn Ile Thr Asp Glu Val Lys Asn Cys Thr Phe Asn Met Thr 
145                 150                 155                 160 


Thr Glu Ile Arg Gly Lys Gln Gln Lys Val His Ala Leu Phe Tyr Ala 
                165                 170                 175     


Leu Asp Ile Val Gln Met Lys Glu Asn Gly Ser Glu Tyr Arg Leu Ile 
            180                 185                 190         


Ser Cys Asn Thr Ser Val Ile Lys Gln Ala Cys Pro Lys Ile Ser Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn Lys 
        275                 280                 285             


Ser Val Ser Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Thr Ser 
    290                 295                 300                 


Ile Arg Ile Gly Pro Gly Gln Met Phe Tyr Arg Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn Gly Thr Glu Trp Asn 
                325                 330                 335     


Glu Thr Leu Asn Gln Val Ala Lys Lys Leu Lys Glu His Phe Lys Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Gln Pro Pro Ser Gly Gly Asp Leu Glu Thr Thr 
        355                 360                 365             


Met His His Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
    370                 375                 380                 


Lys Leu Phe Asn Ser Thr Glu Asn Gly Thr Met Glu Gly Arg Asn Thr 
385                 390                 395                 400 


Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
                405                 410                 415     


Gly Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Ser Gly Ile Ile Asn 
            420                 425                 430         


Cys Thr Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn 
        435                 440                 445             


Asn Asn Ala Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly Asn Ile Lys 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys Arg Arg Val Val Asp Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Ile Gly Ala Met Ile Phe Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Lys Phe Leu Gly Leu Trp Gly Cys Ser Gly Lys Ile Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Thr Trp Ser Asn Lys Ser Tyr Glu 
        595                 600                 605             


Glu Ile Trp Asn Asn Met Thr Trp Ile Glu Trp Glu Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asn Arg Ile Tyr Asp Leu Leu Thr Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Arg Asn Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp Ala Ser 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
        675                 680                 685             


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr Pro Phe His Gln Gln Arg Glu Pro Asp Arg Pro Glu Gly 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser Val Arg Leu 
                725                 730                 735     


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Thr Arg 
        755                 760                 765             


Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Arg Gly 
    770                 775                 780                 


Trp Glu Ser Leu Lys Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln 
785                 790                 795                 800 


Glu Leu Lys Thr Ser Ala Ile Ser Leu Leu Asp Ala Ile Ala Ile Thr 
                805                 810                 815     


Thr Ala Gly Trp Thr Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp 
            820                 825                 830         


Arg Ala Leu Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
        835                 840                 845             


Ala Leu Leu 
    850     


<210>  6
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mmos3.1 mosaic protein

<400>  6

Met Arg Val Met Gly Ile Gln Arg Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu Ala 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Tyr Glu Gly Asn Gly Asn Tyr Thr Thr Val Gln Asn 
    130                 135                 140                 


Asn Thr Ile Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Ala 
145                 150                 155                 160 


Ile Arg Asp Lys Val Gln Lys Thr Tyr Ala Leu Phe Tyr Arg Leu Asp 
                165                 170                 175     


Val Val Pro Ile Lys Asp Thr Asn Asp Ser Arg Thr Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Arg Ala His Cys Asn Leu Ser Arg Thr Ser Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Val Glu Lys Leu Arg Glu Gln Phe Gly Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
    370                 375                 380                 


Gln Leu Phe Asn Ser Thr Trp His Ala Asn Gly Thr Trp Lys Asn Thr 
385                 390                 395                 400 


Glu Gly Ala Asp Asn Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
                405                 410                 415     


Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Asn His Thr Ser Glu Thr Glu Ile Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg 
                485                 490                 495     


Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Met Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser 
        595                 600                 605             


Asn Arg Ser Leu Asn Asp Ile Trp Gln Asn Met Thr Trp Met Glu Trp 
    610                 615                 620                 


Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Thr Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Ala Val Leu Ser Leu Val Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro 
705                 710                 715                 720 


Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Gly Arg Asp 
                725                 730                 735     


Arg Ser Ile Arg Leu Val Asn Gly Phe Ser Ala Leu Ile Trp Asp Asp 
            740                 745                 750         


Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Ile 
        755                 760                 765             


Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu 
    770                 775                 780                 


Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu 
785                 790                 795                 800 


Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala 
                805                 810                 815     


Glu Gly Thr Asp Arg Ile Ile Glu Val Val Gln Arg Ile Cys Arg Ala 
            820                 825                 830         


Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu 
        835                 840                 845             


Gln 
    


<210>  7
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mmos3.2 mosaic protein

<400>  7

Met Arg Val Arg Gly Ile Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Ile Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Ser Asn Arg Thr Val Asp Asn Ala Thr Gln 
    130                 135                 140                 


Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp 
145                 150                 155                 160 


Lys Lys Gln Lys Val Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Leu Pro 
                165                 170                 175     


Leu Asn Gly Asn Asn Asp Ser Asn Glu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg Ser Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Val Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu 
        275                 280                 285             


Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Glu Tyr Lys Trp Asn Lys Thr Leu 
                325                 330                 335     


Gln Arg Val Ser Glu Lys Leu Ala Glu Tyr Phe Pro Asn Asp Thr Ile 
            340                 345                 350         


Lys Phe Ala Pro Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Gly Thr Tyr Asn Ser Thr Tyr Lys Thr Asn Thr Thr Glu Ser Asn 
385                 390                 395                 400 


Ala Thr Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile 
            420                 425                 430         


Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
        435                 440                 445             


Asn Ser Glu Asn Asn Thr Lys Glu Thr Phe Arg Pro Gly Gly Gly Asp 
    450                 455                 460                 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
465                 470                 475                 480 


Ile Lys Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys Arg Arg Val Val 
                485                 490                 495     


Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe 
            500                 505                 510         


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
        515                 520                 525             


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
    530                 535                 540                 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val 
545                 550                 555                 560 


Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr 
                565                 570                 575     


Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
            580                 585                 590         


Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser 
        595                 600                 605             


Tyr Asp Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu 
    610                 615                 620                 


Ile Ser Asn Tyr Ser Asp Thr Ile Tyr Arg Leu Leu Glu Glu Ser Gln 
625                 630                 635                 640 


Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp 
                645                 650                 655     


Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile 
            660                 665                 670         


Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val 
        675                 680                 685             


Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro 
    690                 695                 700                 


Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Leu Asp Arg Pro 
705                 710                 715                 720 


Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile 
                725                 730                 735     


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser 
            740                 745                 750         


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala 
        755                 760                 765             


Ala Arg Thr Val Glu Leu Leu Gly Arg Ser Ser Leu Lys Gly Leu Arg 
    770                 775                 780                 


Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Gln Tyr Trp 
785                 790                 795                 800 


Ile Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala 
                805                 810                 815     


Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val Gln Arg 
            820                 825                 830         


Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe 
        835                 840                 845             


Glu Arg Ala Leu Leu 
    850             


<210>  8
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mmos3.3 mosaic protein

<400>  8

Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Lys Ala Asn Leu Thr Asn Ile Asn Glu Thr Thr Ala Ser 
    130                 135                 140                 


Asn Gly Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Met Thr Thr Leu Leu Ser Asp Lys Lys Arg Leu Val His Ala Leu Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Val Pro Ile Lys Asp Asn Gln Asn Ser Ser Val 
            180                 185                 190         


Ser Ser Gly Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Lys 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Thr Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Ser Asn Asn Thr Arg Thr Ser Val Arg Ile Gly Pro Gly Gln Val 
305                 310                 315                 320 


Phe Tyr Arg Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys 
                325                 330                 335     


Glu Ile Asn Gly Thr Lys Trp Asn Glu Thr Leu Arg Gln Val Ala Lys 
            340                 345                 350         


Lys Leu Lys Glu His Phe Asn Lys Thr Ile Ile Phe Gln Pro Pro Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Met His His Phe Asn Cys Arg Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn Ser Thr Trp Ile Gly 
385                 390                 395                 400 


Asn Glu Thr Met Val Glu Gly Asn Asn Asn Asp Thr Ile Ile Leu Pro 
                405                 410                 415     


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly Val Gly Gln Ala 
            420                 425                 430         


Met Tyr Ala Pro Pro Ile Ser Gly Ile Ile Asn Cys Val Ser Asn Ile 
        435                 440                 445             


Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Ser Gly Asp Asn Ala Thr 
    450                 455                 460                 


Glu Thr Phe Arg Pro Gly Gly Gly Asn Ile Lys Asp Asn Trp Arg Ser 
465                 470                 475                 480 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Glu Pro Leu Gly Ile Ala 
                485                 490                 495     


Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Gly Ile Gly Ala Met Ile Phe Gly Phe Leu Gly Ala Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
    530                 535                 540                 


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Lys Phe Leu 
            580                 585                 590         


Gly Leu Trp Gly Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro 
        595                 600                 605             


Trp Asn Ser Thr Trp Ser Asn Lys Ser Tyr Glu Glu Ile Trp Asn Asn 
    610                 615                 620                 


Met Thr Trp Ile Glu Trp Glu Arg Glu Ile Ser Asn Tyr Thr Ser Gln 
625                 630                 635                 640 


Ile Tyr Glu Ile Leu Thr Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu 
                645                 650                 655     


Lys Asp Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
            660                 665                 670         


Asp Ile Thr Arg Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Pro Thr 
705                 710                 715                 720 


His His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu Glu Glu Gly 
                725                 730                 735     


Gly Glu Gln Gly Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu 
            740                 745                 750         


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
        755                 760                 765             


Arg Leu Arg Asp Leu Leu Leu Ile Val Ala Arg Thr Val Glu Leu Leu 
    770                 775                 780                 


Gly His Ser Ser Leu Lys Gly Leu Arg Arg Gly Trp Glu Gly Leu Lys 
785                 790                 795                 800 


Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Gln Glu Leu Lys Ile Ser 
                805                 810                 815     


Ala Ile Ser Leu Leu Asp Ala Thr Ala Ile Ala Val Ala Gly Trp Thr 
            820                 825                 830         


Asp Arg Val Ile Glu Val Ala Gln Arg Ala Trp Arg Ala Ile Leu His 
        835                 840                 845             


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860         


<210>  9
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA leader peptide

<400>  9

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Arg 
            20              


