                               SEQUENCE LISTING

<110> NEW YORK GENOME CENTER, INC.
 
<120> FUSION PROTEINS AND METHODS OF USE THEREOF

<130> 2205433.145 WO1

<140> PCT/US2014/057580
<141> 2014-09-26

<150> 61/882,929
<151> 2013-09-26

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Gly Lys Asp Tyr Tyr Gln Thr Leu Gly Leu Ala Arg Gly Ala Ser 
1               5                   10                  15      


Asp Glu Glu Ile Lys Arg Ala Tyr Arg Arg Gln Ala Leu Arg Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Gly Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Arg Lys Arg Glu Ile Phe 
    50                  55                  60                  


Asp Arg Tyr Gly Glu Glu Val Lys Glu Phe Leu Ala Lys Ala Lys Glu 
65                  70                  75                  80  


Asp Phe Leu Lys Lys Trp Glu Ser Pro Ala Gln Asn Thr Ala His Leu 
                85                  90                  95      


Asp Gln Phe Glu Arg Ile Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg 
            100                 105                 110         


Val Met Leu Val Lys His Lys Glu Thr Gly Asn His Tyr Ala Met Lys 
        115                 120                 125             


Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr 
    130                 135                 140                 


Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val 
145                 150                 155                 160 


Lys Leu Glu Phe Ser Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met 
                165                 170                 175     


Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly 
            180                 185                 190         


Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu 
        195                 200                 205             


Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys 
    210                 215                 220                 


Pro Glu Asn Leu Leu Ile Asp Gln Gln Gly Tyr Ile Gln Val Thr Asp 
225                 230                 235                 240 


Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly 
                245                 250                 255     


Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn 
            260                 265                 270         


Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala 
        275                 280                 285             


Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu 
    290                 295                 300                 


Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp 
305                 310                 315                 320 


Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg 
                325                 330                 335     


Phe Gly Asn Leu Lys Asn Gly Val Asn Asp Ile Lys Asn His Lys Trp 
            340                 345                 350         


Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala 
        355                 360                 365             


Pro Phe Ile Pro Lys Phe Lys Gly Pro Gly Asp Thr Ser Asn Phe Asp 
    370                 375                 380                 


Asp Tyr Glu Glu Glu Glu Ile Arg Val Ser Ile Asn Glu Lys Cys Gly 
385                 390                 395                 400 


Lys Glu Phe Ser Glu Phe 
                405     


<210> 2
<211> 1221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgggtaaag actactacca gacgttgggc ctggcccgcg gcgcgtcgga cgaggagatc       60

aagcgggcct accgccgcca ggcgctgcgc taccacccgg acaagaacaa ggagcccggc      120

gccgaggaga agttcaagga gatcgctgag gcctacgacg tgctcagcga cccgcgcaag      180

cgcgagatct tcgaccgcta cggggaggaa gtgaaagaat tcttagccaa agccaaagaa      240

gattttctta aaaaatggga aagtcccgct cagaacacag cccacttgga tcagtttgaa      300

cgaatcaaga ccctcggcac gggctccttc gggcgggtga tgctggtgaa acacaaggag      360

accgggaacc actatgccat gaagatcctc gacaaacaga aggtggtgaa actgaaacag      420

atcgaacaca ccctgaatga aaagcgcatc ctgcaagctg tcaactttcc gttcctcgtc      480

aaactcgagt tctccttcaa ggacaactca aacttataca tggtcatgga gtacgtgccc      540

ggcggggaga tgttctcaca cctacggcgg atcggaaggt tcagtgagcc ccatgcccgt      600

ttctacgcgg cccagatcgt cctgaccttt gagtatctgc actcgctgga tctcatctac      660

agggacctga agccggagaa tctgctcatt gaccagcagg gctacattca ggtgacagac      720

ttcggtttcg ccaagcgcgt gaagggccgc acttggacct tgtgcggcac ccctgagtac      780

ctggcccctg agattatcct gagcaaaggc tacaacaagg ccgtggactg gtgggccctg      840

ggggttctta tctatgaaat ggccgctggc tacccgccct tcttcgcaga ccagcccatc      900

cagatctatg agaagatcgt ctctgggaag gtgcgcttcc cttcccactt cagctctgac      960

ttgaaggacc tgctgcggaa cctcctgcag gtagatctca ccaagcgctt tgggaacctc     1020

aagaatgggg tcaacgatat caagaaccac aagtggtttg ccacaactga ctggattgcc     1080

atctaccaga ggaaggtgga agctcccttc ataccaaagt ttaaaggccc tggggatacg     1140

agtaactttg acgactatga ggaagaagaa atccgggtct ccatcaatga gaagtgtggc     1200

aaggagtttt ctgagtttta g                                               1221


<210> 3
<211> 351
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210> 4
<211> 2689
<212> DNA
<213> Homo sapiens

<400> 4
gatcttgggc tgaggttccc gggcgggcgg gcgcggagag acgcgggaag caggggctgg       60

gcgggggtcg cggcgccgca gctagcgcag ccagcccgag ggccgccgcc gccgccgccc      120

agcgcgctcc ggggccgccg gccgcagcca gcacccgccg cgccgcagct ccgggaccgg      180

ccccggccgc cgccgccgcg atgggcaacg ccgccgccgc caagaagggc agcgagcagg      240

agagcgtgaa agaattctta gccaaagcca aagaagattt tcttaaaaaa tgggaaagtc      300

ccgctcagaa cacagcccac ttggatcagt ttgaacgaat caagaccctc ggcacgggct      360

ccttcgggcg ggtgatgctg gtgaaacaca aggagaccgg gaaccactat gccatgaaga      420

tcctcgacaa acagaaggtg gtgaaactga aacagatcga acacaccctg aatgaaaagc      480

gcatcctgca agctgtcaac tttccgttcc tcgtcaaact cgagttctcc ttcaaggaca      540

actcaaactt atacatggtc atggagtacg tgcccggcgg ggagatgttc tcacacctac      600

ggcggatcgg aaggttcagt gagccccatg cccgtttcta cgcggcccag atcgtcctga      660

cctttgagta tctgcactcg ctggatctca tctacaggga cctgaagccg gagaatctgc      720

tcattgacca gcagggctac attcaggtga cagacttcgg tttcgccaag cgcgtgaagg      780

gccgcacttg gaccttgtgc ggcacccctg agtacctggc ccctgagatt atcctgagca      840

aaggctacaa caaggccgtg gactggtggg ccctgggggt tcttatctat gaaatggccg      900

ctggctaccc gcccttcttc gcagaccagc ccatccagat ctatgagaag atcgtctctg      960

ggaaggtgcg cttcccttcc cacttcagct ctgacttgaa ggacctgctg cggaacctcc     1020

tgcaggtaga tctcaccaag cgctttggga acctcaagaa tggggtcaac gatatcaaga     1080

accacaagtg gtttgccaca actgactgga ttgccatcta ccagaggaag gtggaagctc     1140

ccttcatacc aaagtttaaa ggccctgggg atacgagtaa ctttgacgac tatgaggaag     1200

aagaaatccg ggtctccatc aatgagaagt gtggcaagga gttttctgag ttttaggggc     1260

atgcctgtgc ccccatgggt tttctttttt cttttttctt ttttttggtc gggggggtgg     1320

gagggttgga ttgaacagcc agagggcccc agagttcctt gcatctaatt tcacccccac     1380

cccaccctcc agggttaggg ggagcaggaa gcccagataa tcagagggac agaaacacca     1440

gctgctcccc ctcatcccct tcaccctcct gccccctctc ccacttttcc cttcctcttt     1500

ccccacagcc ccccagcccc tcagccctcc cagcccactt ctgcctgttt taaacgagtt     1560

tctcaactcc agtcagacca ggtcttgctg gtgtatccag ggacagggta tggaaagagg     1620

ggctcacgct taactccagc ccccacccac acccccatcc cacccaacca caggccccac     1680

ttgctaaggg caaatgaacg aagcgccaac cttcctttcg gagtaatcct gcctgggaag     1740

gagagatttt tagtgacatg ttcagtgggt tgcttgctag aattttttta aaaaaacaac     1800

aatttaaaat cttatttaag ttccaccagt gcctccctcc ctccttcctc tactcccacc     1860

cctcccatgt ccccccattc ctcaaatcca ttttaaagag aagcagactg actttggaaa     1920

gggaggcgct ggggtttgaa cctccccgct gctaatctcc cctgggcccc tccccgggga     1980

atcctctctg ccaatcctgc gagggtctag gcccctttag gaagcctccg ctctcttttt     2040

ccccaacaga cctgtcttca cccttgggct ttgaaagcca gacaaagcag ctgcccctct     2100

ccctgccaaa gaggagtcat cccccaaaaa gacagagggg gagccccaag cccaagtctt     2160

tcctcccagc agcgtttccc cccaactcct taattttatt ctccgctaga ttttaacgtc     2220

cagccttccc tcagctgagt ggggagggca tccctgcaaa agggaacaga agaggccaag     2280

tccccccaag ccacggcccg gggttcaagg ctagagctgc tggggagggg ctgcctgttt     2340

tactcaccca ccagcttccg cctcccccat cctgggcgcc cctcctccag cttagctgtc     2400

agctgtccat cacctctccc ccactttctc atttgtgctt ttttctctcg taatagaaaa     2460

gtggggagcc gctggggagc caccccattc atccccgtat ttccccctct cataacttct     2520

ccccatccca ggaggagttc tcaggcctgg ggtggggccc cgggtgggtg cgggggcgat     2580

tcaacctgtg tgctgcgaag gacgagactt cctcttgaac agtgtgctgt tgtaaacata     2640

tttgaaaact attaccaata aagttttgtt taaaaaaaaa aaaaaaaaa                 2689


<210> 5
<211> 340
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Lys Asp Tyr Tyr Gln Thr Leu Gly Leu Ala Arg Gly Ala Ser 
1               5                   10                  15      


Asp Glu Glu Ile Lys Arg Ala Tyr Arg Arg Gln Ala Leu Arg Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Gly Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Arg Lys Arg Glu Ile Phe 
    50                  55                  60                  


Asp Arg Tyr Gly Glu Glu Gly Leu Lys Gly Ser Gly Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Ala Asn Gly Thr Ser Phe Ser Tyr Thr Phe His Gly 
                85                  90                  95      


Asp Pro His Ala Met Phe Ala Glu Phe Phe Gly Gly Arg Asn Pro Phe 
            100                 105                 110         


Asp Thr Phe Phe Gly Gln Arg Asn Gly Glu Glu Gly Met Asp Ile Asp 
        115                 120                 125             


Asp Pro Phe Ser Gly Phe Pro Met Gly Met Gly Gly Phe Thr Asn Val 
    130                 135                 140                 


Asn Phe Gly Arg Ser Arg Ser Ala Gln Glu Pro Ala Arg Lys Lys Gln 
145                 150                 155                 160 


Asp Pro Pro Val Thr His Asp Leu Arg Val Ser Leu Glu Glu Ile Tyr 
                165                 170                 175     


Ser Gly Cys Thr Lys Lys Met Lys Ile Ser His Lys Arg Leu Asn Pro 
            180                 185                 190         


Asp Gly Lys Ser Ile Arg Asn Glu Asp Lys Ile Leu Thr Ile Glu Val 
        195                 200                 205             


Lys Lys Gly Trp Lys Glu Gly Thr Lys Ile Thr Phe Pro Lys Glu Gly 
    210                 215                 220                 


Asp Gln Thr Ser Asn Asn Ile Pro Ala Asp Ile Val Phe Val Leu Lys 
225                 230                 235                 240 


Asp Lys Pro His Asn Ile Phe Lys Arg Asp Gly Ser Asp Val Ile Tyr 
                245                 250                 255     


Pro Ala Arg Ile Ser Leu Arg Glu Ala Leu Cys Gly Cys Thr Val Asn 
            260                 265                 270         


Val Pro Thr Leu Asp Gly Arg Thr Ile Pro Val Val Phe Lys Asp Val 
        275                 280                 285             


Ile Arg Pro Gly Met Arg Arg Lys Val Pro Gly Glu Gly Leu Pro Leu 
    290                 295                 300                 


Pro Lys Thr Pro Glu Lys Arg Gly Asp Leu Ile Ile Glu Phe Glu Val 
305                 310                 315                 320 


Ile Phe Pro Glu Arg Ile Pro Gln Thr Ser Arg Thr Val Leu Glu Gln 
                325                 330                 335     


Val Leu Pro Ile 
            340 


<210> 6
<211> 2233
<212> DNA
<213> Homo sapiens

<400> 6
gggacggcga cagcgggtcg gcgggccgca ggagggggtc atgggtaaag actactacca       60

gacgttgggc ctggcccgcg gcgcgtcgga cgaggagatc aagcgggcct accgccgcca      120

ggcgctgcgc taccacccgg acaagaacaa ggagcccggc gccgaggaga agttcaagga      180

gatcgctgag gcctacgacg tgctcagcga cccgcgcaag cgcgagatct tcgaccgcta      240

cggggaggaa ggcctaaagg ggagtggccc cagtggcggt agcggcggtg gtgccaatgg      300

tacctctttc agctacacat tccatggaga ccctcatgcc atgtttgctg agttcttcgg      360

tggcagaaat ccctttgaca ccttttttgg gcagcggaac ggggaggaag gcatggacat      420

tgatgaccca ttctctggct tccctatggg catgggtggc ttcaccaacg tgaactttgg      480

ccgctcccgc tctgcccaag agcccgcccg aaagaagcaa gatcccccag tcacccacga      540

ccttcgagtc tcccttgaag agatctacag cggctgtacc aagaagatga aaatctccca      600

caagcggcta aaccccgacg gaaagagcat tcgaaacgaa gacaaaatat tgaccatcga      660

agtgaagaag gggtggaaag aaggaaccaa aatcactttc cccaaggaag gagaccagac      720

ctccaacaac attccagctg atatcgtctt tgttttaaag gacaagcccc acaatatctt      780

taagagagat ggctctgatg tcatttatcc tgccaggatc agcctccggg aggctctgtg      840

tggctgcaca gtgaacgtcc ccactctgga cggcaggacg atacccgtcg tattcaaaga      900

tgttatcagg cctggcatgc ggcgaaaagt tcctggagaa ggcctccccc tccccaaaac      960

acccgagaaa cgtggggacc tcattattga gtttgaagtg atcttccccg aaaggattcc     1020

ccagacatca agaaccgtac ttgagcaggt tcttccaata tagctatctg agctccccaa     1080

ggactgacca gggacctttc cagagctcaa ggatttctgg acctttctac cagttgtgga     1140

ccatgagagg gtgggagggc ccagggaggg ctttcgtact gctgaatgtt ttccagagca     1200

tatattacaa tctttcaaag tcgcacacta gacttcagtg gtttttcgag ctatagggca     1260

tcaggtggtg ggaacagcag gaaaaggcat tccagtctgc cccactgggt ctggcagccc     1320

tcccgggatg ggcccacatc cacctccagt ccctggccag gggtgagagg cagaccagca     1380

gatggacttg atccctctgt gtctttgggc ttctggctgg tagataatgt caacctgcag     1440

tcttgattcc cagaccctgt acactcctcc ttttctgttg tgtgatcagt ttgtgcttta     1500

ttctgtattt gtctcccatg tcttgctctt ctcctggaga attctgtctt ctctttggcc     1560

atctcaaatt gagaacctaa actattcctg cagaactgcc tggttggcgt ccacaagcaa     1620

tacctctcgt tccagcagga ccaagggagc cagcctccag tgagtgactc cagcaagtgc     1680

agccacctct cccttgatgg tctgggagcc tggcctcagc aaggggcctt cctgacctct     1740

ggctccagtg aagctgaatg tcctcacttt gtgggtcaca ctctttacat ttctgtaagg     1800

caatcttggc acacgtgggg cttaccagtg gcccaggtaa ttttttgttt catggactat     1860

ggactctttc aaagggatct gatccttttg aattttgcac agccctagat acaatccctt     1920

ttgataaaag ggtctttgct tctgattaca ggagcactgt ggaacgtctg taaatatgtt     1980

tttataattc catgtatagt tggtgtacac tcaaaacctg tccccggcag ccagtgctct     2040

ctgtataggg ccataatgga attctgaaga aatcttgggg agggaagggg agttggaaca     2100

aatgtctgtt ccctggaggc cagtccagtg ctcagacctt tagactcatt gtaagttgcc     2160

actgccaaca tgagaccaaa gtgtgtgact agtcaatgaa gtgcgacagc attaaagact     2220

gatgctaaac ctc                                                        2233


