                               SEQUENCE LISTING

<110> COSTIM PHARMACEUTICALS INC.
      THE MEDICAL COLLEGE OF WISCONSIN, INC.
 
<120> METHODS FOR TREATING HEMATOLOGIC CANCERS

<130> C2160-7004WO

<140> PCT/US2014/057491
<141> 2014-09-25

<150> 62/017,192
<151> 2014-06-25

<150> 61/882,702
<151> 2013-09-26

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 921
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (25)..(888)

<400> 1
cactctggtg gggctgctcc aggc atg cag atc cca cag gcg ccc tgg cca          51
                           Met Gln Ile Pro Gln Ala Pro Trp Pro            
                           1               5                              

gtc gtc tgg gcg gtg cta caa ctg ggc tgg cgg cca gga tgg ttc tta         99
Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu           
10                  15                  20                  25            

gac tcc cca gac agg ccc tgg aac ccc ccc acc ttc tcc cca gcc ctg        147
Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu           
                30                  35                  40                

ctc gtg gtg acc gaa ggg gac aac gcc acc ttc acc tgc agc ttc tcc        195
Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser           
            45                  50                  55                    

aac aca tcg gag agc ttc gtg cta aac tgg tac cgc atg agc ccc agc        243
Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser           
        60                  65                  70                        

aac cag acg gac aag ctg gcc gcc ttc ccc gag gac cgc agc cag ccc        291
Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro           
    75                  80                  85                            

ggc cag gac tgc cgc ttc cgt gtc aca caa ctg ccc aac ggg cgt gac        339
Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp           
90                  95                  100                 105           

ttc cac atg agc gtg gtc agg gcc cgg cgc aat gac agc ggc acc tac        387
Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr           
                110                 115                 120               

ctc tgt ggg gcc atc tcc ctg gcc ccc aag gcg cag atc aaa gag agc        435
Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser           
            125                 130                 135                   

ctg cgg gca gag ctc agg gtg aca gag aga agg gca gaa gtg ccc aca        483
Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr           
        140                 145                 150                       

gcc cac ccc agc ccc tca ccc agg tca gcc ggc cag ttc caa acc ctg        531
Ala His Pro Ser Pro Ser Pro Arg Ser Ala Gly Gln Phe Gln Thr Leu           
    155                 160                 165                           

gtg gtt ggt gtc gtg ggc ggc ctg ctg ggc agc ctg gtg ctg cta gtc        579
Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val           
170                 175                 180                 185           

tgg gtc ctg gcc gtc atc tgc tcc cgg gcc gca cga ggg aca ata gga        627
Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly           
                190                 195                 200               

gcc agg cgc acc ggc cag ccc ctg aag gag gac ccc tca gcc gtg cct        675
Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro           
            205                 210                 215                   

gtg ttc tct gtg gac tat ggg gag ctg gat ttc cag tgg cga gag aag        723
Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys           
        220                 225                 230                       

acc ccg gag ccc ccc gtg ccc tgt gtc cct gag cag acg gag tat gcc        771
Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala           
    235                 240                 245                           

acc att gtc ttt cct agc gga atg ggc acc tca tcc ccc gcc cgc agg        819
Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg           
250                 255                 260                 265           

ggc tca gct gac ggc cct cgg agt gcc cag cca ctg agg cct gag gat        867
Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp           
                270                 275                 280               

gga cac tgc tct tgg ccc ctc tgaccggctt ccttggccac cagtgttctg cag       921
Gly His Cys Ser Trp Pro Leu                                               
            285                                                           


<210> 2
<211> 288
<212> PRT
<213> Homo sapiens

<400> 2
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Ser Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 3
<211> 968
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (59)..(793)

<400> 3
gcttcccgag gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaag         58

atg agg ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg        106
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu           
1               5                   10                  15                

aac gca ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat        154
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr           
            20                  25                  30                    

ggt agc aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta        202
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu           
        35                  40                  45                        

gac ctg gct gca cta att gtc tat tgg gaa atg gag gat aag aac att        250
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile           
    50                  55                  60                            

att caa ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc        298
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser           
65                  70                  75                  80            

tac aga cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat        346
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn           
                85                  90                  95                

gct gca ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac        394
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr           
            100                 105                 110                   

cgc tgc atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg        442
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val           
        115                 120                 125                       

aaa gtc aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg        490
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val           
    130                 135                 140                           

gat cca gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac        538
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr           
145                 150                 155                 160           

ccc aag gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt        586
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser           
                165                 170                 175               

ggt aag acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat        634
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn           
            180                 185                 190                   

gtg acc agc aca ctg aga atc aac aca aca act aat gag att ttc tac        682
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr           
        195                 200                 205                       

tgc act ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg        730
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu           
    210                 215                 220                           

gtc atc cca ggt aat att ctg aat gtg tcc att aaa ata tgt cta aca        778
Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr           
225                 230                 235                 240           

ctg tcc cct agc acc tagcatgatg tctgcctatc atagtcattc agtgattgtt        833
Leu Ser Pro Ser Thr                                                       
                245                                                       

gaataaatga atgaatgaat aacactatgt ttacaaaata tatcctaatt cctcacctcc      893

attcatccaa accatattgt tacttaataa acattcagca gatatttatg gaataaaaaa      953

aaaaaaaaaa aaaaa                                                       968


<210> 4
<211> 245
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210> 5
<211> 1553
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (53)..(922)

<400> 5
cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa ag atg agg       58
                                                          Met Arg         
                                                          1               

ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg aac gca        106
Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala           
        5                   10                  15                        

ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat ggt agc        154
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser           
    20                  25                  30                            

aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta gac ctg        202
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu           
35                  40                  45                  50            

gct gca cta att gtc tat tgg gaa atg gag gat aag aac att att caa        250
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln           
                55                  60                  65                

ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc tac aga        298
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg           
            70                  75                  80                    

cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat gct gca        346
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala           
        85                  90                  95                        

ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac cgc tgc        394
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys           
    100                 105                 110                           

atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg aaa gtc        442
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val           
115                 120                 125                 130           

aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg gat cca        490
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro           
                135                 140                 145               

gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac ccc aag        538
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys           
            150                 155                 160                   

gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt ggt aag        586
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys           
        165                 170                 175                       

acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat gtg acc        634
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr           
    180                 185                 190                           

agc aca ctg aga atc aac aca aca act aat gag att ttc tac tgc act        682
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr           
195                 200                 205                 210           

ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg gtc atc        730
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile           
                215                 220                 225               

cca gaa cta cct ctg gca cat cct cca aat gaa agg act cac ttg gta        778
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val           
            230                 235                 240                   

att ctg gga gcc atc tta tta tgc ctt ggt gta gca ctg aca ttc atc        826
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile           
        245                 250                 255                       

ttc cgt tta aga aaa ggg aga atg atg gat gtg aaa aaa tgt ggc atc        874
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile           
    260                 265                 270                           

caa gat aca aac tca aag aag caa agt gat aca cat ttg gag gag acg        922
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr           
275                 280                 285                 290           

taatccagca ttggaacttc tgatcttcaa gcagggattc tcaacctgtg gtttaggggt      982

tcatcggggc tgagcgtgac aagaggaagg aatgggcccg tgggatgcag gcaatgtggg     1042

acttaaaagg cccaagcact gaaaatggaa cctggcgaaa gcagaggagg agaatgaaga     1102

aagatggagt caaacaggga gcctggaggg agaccttgat actttcaaat gcctgagggg     1162

ctcatcgacg cctgtgacag ggagaaagga tacttctgaa caaggagcct ccaagcaaat     1222

catccattgc tcatcctagg aagacgggtt gagaatccct aatttgaggg tcagttcctg     1282

cagaagtgcc ctttgcctcc actcaatgcc tcaatttgtt ttctgcatga ctgagagtct     1342

cagtgttgga acgggacagt atttatgtat gagtttttcc tatttatttt gagtctgtga     1402

ggtcttcttg tcatgtgagt gtggttgtga atgatttctt ttgaagatat attgtagtag     1462

atgttacaat tttgtcgcca aactaaactt gctgcttaat gatttgctca catctagtaa     1522

aacatggagt atttgtaaaa aaaaaaaaaa a                                    1553


<210> 6
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 7
<211> 873
<212> DNA
<213> Mus sp.

<400> 7
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactcactgg      720

gtgcttctgg gatccatcct gttgttcctc attgtagtgt ccacggtcct cctcttcttg      780

agaaaacaag tgagaatgct agatgtggag aaatgtggcg ttgaagatac aagctcaaaa      840

aaccgaaatg atacacaatt cgaggagacg taa                                   873


<210> 8
<211> 290
<212> PRT
<213> Mus sp.

<400> 8
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr His Trp 
225                 230                 235                 240 


Val Leu Leu Gly Ser Ile Leu Leu Phe Leu Ile Val Val Ser Thr Val 
                245                 250                 255     


Leu Leu Phe Leu Arg Lys Gln Val Arg Met Leu Asp Val Glu Lys Cys 
            260                 265                 270         


Gly Val Glu Asp Thr Ser Ser Lys Asn Arg Asn Asp Thr Gln Phe Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 9
<211> 906
<212> DNA
<213> Homo sapiens

<400> 9
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga      600

ataggcatct acatcggagc agggatctgt gctgggctgg ctctggctct tatcttcggc      660

gctttaattt tcaaatggta ttctcatagc aaagagaaga tacagaattt aagcctcatc      720

tctttggcca acctccctcc ctcaggattg gcaaatgcag tagcagaggg aattcgctca      780

gaagaaaaca tctataccat tgaagagaac gtatatgaag tggaggagcc caatgagtat      840

tattgctatg tcagcagcag gcagcaaccc tcacaacctt tgggttgtcg ctttgcaatg      900

ccatag                                                                 906


<210> 10
<211> 301
<212> PRT
<213> Homo sapiens

<400> 10
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210> 11
<211> 846
<212> DNA
<213> Mus sp.

<400> 11
atgttttcag gtcttaccct caactgtgtc ctgctgctgc tgcaactact acttgcaagg       60

tcattggaaa atgcttatgt gtttgaggtt ggtaagaatg cctatctgcc ctgcagttac      120

actctatcta cacctggggc acttgtgcct atgtgctggg gcaagggatt ctgtccttgg      180

tcacagtgta ccaacgagtt gctcagaact gatgaaagaa atgtgacata tcagaaatcc      240

agcagatacc agctaaaggg cgatctcaac aaaggagacg tgtctctgat cataaagaat      300

gtgactctgg atgaccatgg gacctactgc tgcaggatac agttccctgg tcttatgaat      360

gataaaaaat tagaactgaa attagacatc aaagcagcca aggtcactcc agctcagact      420

gcccatgggg actctactac agcttctcca agaaccctaa ccacggagag aaatggttca      480

gagacacaga cactggtgac cctccataat aacaatggaa caaaaatttc cacatgggct      540

gatgaaatta aggactctgg agaaacgatc agaactgcta tccacattgg agtgggagtc      600

tctgctgggt tgaccctggc acttatcatt ggtgtcttaa tccttaaatg gtattcctgt      660

aagaaaaaga agttatcgag tttgagcctt attacactgg ccaacttgcc tccaggaggg      720

ttggcaaatg caggagcagt caggattcgc tctgaggaaa atatctacac catcgaggag      780

aacgtatatg aagtggagaa ttcaaatgag tactactgct acgtcaacag ccagcagcca      840

tcctga                                                                 846


<210> 12
<211> 281
<212> PRT
<213> Mus sp.

<400> 12
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asn Ala Tyr Val Phe Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Ser Thr Pro Gly Ala Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


<210> 13
<211> 1578
<212> DNA
<213> Homo sapiens

<400> 13
atgtgggagg ctcagttcct gggcttgctg tttctgcagc cgctttgggt ggctccagtg       60

aagcctctcc agccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc      120

cagctcccct gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg      180

gtcacttggc agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg      240

gcccccggcc ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg      300

gtgctgagcg tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc      360

cagctggatg agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg      420

cgcgcggacg ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc      480

cgcctccgtc tgcgcctggg ccaggcctcg atgactgcca gccccccagg atctctcaga      540

gcctccgact gggtcatttt gaactgctcc ttcagccgcc ctgaccgccc agcctctgtg      600

cattggttcc ggaaccgggg ccagggccga gtccctgtcc gggagtcccc ccatcaccac      660

ttagcggaaa gcttcctctt cctgccccaa gtcagcccca tggactctgg gccctggggc      720

tgcatcctca cctacagaga tggcttcaac gtctccatca tgtataacct cactgttctg      780

ggtctggagc ccccaactcc cttgacagtg tacgctggag caggttccag ggtggggctg      840

ccctgccgcc tgcctgctgg tgtggggacc cggtctttcc tcactgccaa gtggactcct      900

cctgggggag gccctgacct cctggtgact ggagacaatg gcgactttac ccttcgacta      960

gaggatgtga gccaggccca ggctgggacc tacacctgcc atatccatct gcaggaacag     1020

cagctcaatg ccactgtcac attggcaatc atcacagtga ctcccaaatc ctttgggtca     1080

cctggatccc tggggaagct gctttgtgag gtgactccag tatctggaca agaacgcttt     1140

gtgtggagct ctctggacac cccatcccag aggagtttct caggaccttg gctggaggca     1200

caggaggccc agctcctttc ccagccttgg caatgccagc tgtaccaggg ggagaggctt     1260

cttggagcag cagtgtactt cacagagctg tctagcccag gtgcccaacg ctctgggaga     1320

gccccaggtg ccctcccagc aggccacctc ctgctgtttc tcatccttgg tgtcctttct     1380

ctgctccttt tggtgactgg agcctttggc tttcaccttt ggagaagaca gtggcgacca     1440

agacgatttt ctgccttaga gcaagggatt caccctccgc aggctcagag caagatagag     1500

gagctggagc aagaaccgga gccggagccg gagccggaac cggagcccga gcccgagccc     1560

gagccggagc agctctga                                                   1578


<210> 14
<211> 525
<212> PRT
<213> Homo sapiens

<400> 14
Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210> 15
<211> 1566
<212> DNA
<213> Mus sp.

<400> 15
atgagggagg acctgctcct tggctttttg cttctgggac tgctttggga agctccagtt       60

gtgtcttcag ggcctgggaa agagctcccc gtggtgtggg cccaggaggg agctcccgtc      120

catcttccct gcagcctcaa atcccccaac ctggatccta actttctacg aagaggaggg      180

gttatctggc aacatcaacc agacagtggc caacccactc ccatcccggc ccttgacctt      240

caccagggga tgccctcgcc tagacaaccc gcacccggtc gctacacggt gctgagcgtg      300

gctccaggag gcctgcgcag cgggaggcag cccctgcatc cccacgtgca gctggaggag      360

cgcggcctcc agcgcgggga cttctctctg tggttgcgcc cagctctgcg caccgatgcg      420

ggcgagtacc acgccaccgt gcgcctcccg aaccgcgccc tctcctgcag tctccgcctg      480

cgcgtcggcc aggcctcgat gattgctagt ccctcaggag tcctcaagct gtctgattgg      540

gtccttttga actgctcctt cagccgtcct gaccgcccag tctctgtgca ctggttccag      600

ggccagaacc gagtgcctgt ctacaactca ccgcgtcatt ttttagctga aactttcctg      660

ttactgcccc aagtcagccc cctggactct gggacctggg gctgtgtcct cacctacaga      720

gatggcttca atgtctccat cacgtacaac ctcaaggttc tgggtctgga gcccgtagcc      780

cctctgacag tgtacgctgc tgaaggttct agggtggagc tgccctgtca tttgccccca      840

ggagtgggga ccccttcttt gctcattgcc aagtggactc ctcctggagg aggtcctgag      900

ctccccgtgg ctggaaagag tggcaatttt acccttcacc ttgaggctgt gggtctggca      960

caggctggga cctacacctg tagcatccat ctgcagggac agcagctcaa tgccactgtc     1020

acgttggcgg tcatcacagt gactcccaaa tccttcgggt tacctggctc ccgggggaag     1080

ctgttgtgtg aggtaacccc ggcatctgga aaggaaagat ttgtgtggcg tcccctgaac     1140

aatctgtcca ggagttgccc gggccctgtg ctggagattc aggaggccag gctccttgct     1200

gagcgatggc agtgtcagct gtacgagggc cagaggcttc ttggagcgac agtgtacgcc     1260

gcagagtcta gctcaggcgc ccacagtgct aggagaatct caggtgacct taaaggaggc     1320

catctcgttc tcgttctcat ccttggtgcc ctctccctgt tccttttggt ggccggggcc     1380

tttggctttc actggtggag aaaacagttg ctactgagaa gattttctgc cttagaacat     1440

gggattcagc catttccggc tcagaggaag atagaggagc tggagcgaga actggagacg     1500

gagatgggac aggagccgga gcccgagccg gagccacagc tggagccaga gcccaggcag     1560

ctctga                                                                1566


<210> 16
<211> 521
<212> PRT
<213> Mus sp.

<400> 16
Met Arg Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Lys Glu Leu Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Val His Leu Pro Cys Ser Leu Lys Ser 
        35                  40                  45              


Pro Asn Leu Asp Pro Asn Phe Leu Arg Arg Gly Gly Val Ile Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Gln Pro Thr Pro Ile Pro Ala Leu Asp Leu 
65                  70                  75                  80  


His Gln Gly Met Pro Ser Pro Arg Gln Pro Ala Pro Gly Arg Tyr Thr 
                85                  90                  95      


Val Leu Ser Val Ala Pro Gly Gly Leu Arg Ser Gly Arg Gln Pro Leu 
            100                 105                 110         


His Pro His Val Gln Leu Glu Glu Arg Gly Leu Gln Arg Gly Asp Phe 
        115                 120                 125             


Ser Leu Trp Leu Arg Pro Ala Leu Arg Thr Asp Ala Gly Glu Tyr His 
    130                 135                 140                 


Ala Thr Val Arg Leu Pro Asn Arg Ala Leu Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Arg Val Gly Gln Ala Ser Met Ile Ala Ser Pro Ser Gly Val Leu Lys 
                165                 170                 175     


Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg 
            180                 185                 190         


Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg Val Pro Val Tyr 
        195                 200                 205             


Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu Leu Leu Pro Gln 
    210                 215                 220                 


Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val Leu Thr Tyr Arg 
225                 230                 235                 240 


Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys Val Leu Gly Leu 
                245                 250                 255     


Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu Gly Ser Arg Val 
            260                 265                 270         


Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr Pro Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu Leu Pro Val Ala 
    290                 295                 300                 


Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala Val Gly Leu Ala 
305                 310                 315                 320 


Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln Gly Gln Gln Leu 
                325                 330                 335     


Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr Pro Lys Ser Phe 
            340                 345                 350         


Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
        355                 360                 365             


Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn Asn Leu Ser Arg 
    370                 375                 380                 


Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg Leu Leu Gly Ala 
                405                 410                 415     


Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His Ser Ala Arg Arg 
            420                 425                 430         


Ile Ser Gly Asp Leu Lys Gly Gly His Leu Val Leu Val Leu Ile Leu 
        435                 440                 445             


Gly Ala Leu Ser Leu Phe Leu Leu Val Ala Gly Ala Phe Gly Phe His 
    450                 455                 460                 


Trp Trp Arg Lys Gln Leu Leu Leu Arg Arg Phe Ser Ala Leu Glu His 
465                 470                 475                 480 


Gly Ile Gln Pro Phe Pro Ala Gln Arg Lys Ile Glu Glu Leu Glu Arg 
                485                 490                 495     


Glu Leu Glu Thr Glu Met Gly Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Gln Leu Glu Pro Glu Pro Arg Gln Leu 
        515                 520     


