                               SEQUENCE LISTING

<110> AMGEN INC.
 
<120> V-C-FC-V-C ANTIBODY

<130> A-1843-WO-PCT

<140> to be assigned
<141> 2014-09-25

<150> 61/882,428
<151> 2013-09-25

<160> 101   

<170> PatentIn version 3.5

<210> 1
<211> 708
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            500                 505                 510         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        515                 520                 525             


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    530                 535                 540                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
545                 550                 555                 560 


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            580                 585                 590         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        595                 600                 605             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    610                 615                 620                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
625                 630                 635                 640 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                645                 650                 655     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            660                 665                 670         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        675                 680                 685             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    690                 695                 700                 


Pro Lys Ser Cys 
705             


<210> 2
<211> 2124
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgcttact actggacctg gatccgccag      180

cacccaggga agggcctgga gtggattggg tacatctatt acagtgggag cacctactac      240

aacccgtccc tcaagagtcg agttagcata tcaatagaca cgtctaagaa ccagttctcc      300

ctgaagctga gctctgtgac tgccgcggac acggccgtgt attactgtgc gcgaggcagc      360

agcagctggt tcgactactg gggccaggga accctggtca ccgtctcctc agctagcacc      420

aagggcccat ccgtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag cagctggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccggaagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctgaagtcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa agcggccgct ggaggcggcg gttcaggcgg aggtggctct     1440

gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc     1500

tcatgtgcag cctctggatt caccttcaat agctacgcca tgaactgggt ccgccaggct     1560

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca     1620

tattatgccg attcagtgaa aggcaggttc accatctcca gagatgattc aaaaaacact     1680

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga     1740

catgggaact tcggtaatag ctacgtttcc tggtgggctt actggggcca agggactctg     1800

gtcaccgtct cctcagctag caccaagggc ccatccgtct tccccctggc accctcctcc     1860

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa     1920

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     1980

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     2040

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac     2100

aagagagttg agcccaaatc ttgt                                            2124


<210> 3
<211> 690
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala 
            20                  25                  30          


Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser Ser Gly Val Ser Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
                85                  90                  95      


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala 
    450                 455                 460                 


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr 
465                 470                 475                 480 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                485                 490                 495     


Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
            500                 505                 510         


Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
        515                 520                 525             


Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
    530                 535                 540                 


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
545                 550                 555                 560 


Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
                565                 570                 575     


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
            580                 585                 590         


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
        595                 600                 605             


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
    610                 615                 620                 


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
625                 630                 635                 640 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
                645                 650                 655     


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
            660                 665                 670         


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
        675                 680                 685             


Cys Ser 
    690 


<210> 4
<211> 2070
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcccag       60

tctgtgctga ctcagccacc ctcggtgtct gaagccccca ggcagagggt caccatctcc      120

tgttctggaa gcagctccaa catcggaaat aatgctgtaa actggtacca gcagctccca      180

ggaaaggctc ccaaactcct catctattat gatgatatgt tgtcttcagg ggtctcggac      240

cgattttctg gctccaagtc tggcacctca gcctccctgg ccatcagtgg gctccagtct      300

gaggatgagg ctgattatta ctgtgcagca tgggatgaca gcctgaatgg tgtggtattc      360

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      420

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      480

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg      540

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      600

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      660

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcagacaa aactcacaca      720

tgcccaccgt gcccagcacc tgaagcagct gggggaccgt cagtcttcct cttcccccca      780

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      840

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      900

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      960

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1020

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1080

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacga caccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctatagcg agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1380

ggtaaagcgg ccgctggagg cggcggttca ggcggaggtg gctctcagac tgttgtgact     1440

caggaacctt cactcaccgt atcacctggt ggaacagtca cactcacttg tggctcctcg     1500

actggggctg ttacatctgg caactaccca aactgggtcc aacaaaaacc aggtcaggca     1560

ccccgtggtc taataggtgg gactaagttc ctcgcccccg gtactcctgc cagattctca     1620

ggctccctgc ttggaggcaa ggctgccctc accctctcag gggtacagcc agaggatgag     1680

gcagaatatt actgtgttct atggtacagc aaccgctggg tgttcggtgg aggaaccaaa     1740

ctgactgtcc taggtcagcc caaggctgcc ccctcggtca ctctgttccc gccctcctct     1800

gaggagcttc aagccaacaa ggccacactg gtgtgtctca taagtgactt ctacccggga     1860

gccgtgacag tggcctggaa ggcagatagc agccccgtca aggcgggagt ggagaccacc     1920

acaccctcca aacaaagcaa caacaagtac gcggccagca gctatctgag cctgacgcct     1980

gagcagtgga agtcccacag aagctacagc tgccaggtca cgcatgaagg gagcaccgtg     2040

gagaagacag tggcccctac agaatgttca                                      2070


<210> 5
<211> 708
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
        115                 120                 125             


Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
                485                 490                 495     


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
            500                 505                 510         


Gly Gly Ser Ile Ser Ser Gly Ala Tyr Tyr Trp Thr Trp Ile Arg Gln 
        515                 520                 525             


His Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly 
    530                 535                 540                 


Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Ser Ile 
545                 550                 555                 560 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
                565                 570                 575     


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ser Ser Trp Phe 
            580                 585                 590         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        595                 600                 605             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    610                 615                 620                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
625                 630                 635                 640 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                645                 650                 655     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            660                 665                 670         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        675                 680                 685             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    690                 695                 700                 


Pro Lys Ser Cys 
705             


<210> 6
<211> 2124
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgg tcgagtctgg aggaggattg gtgcagcctg gagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatagc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaat ataataatta tgcaacatat      240

tatgccgatt cagtgaaagg caggttcacc atctccagag atgattcaaa aaacactgcc      300

tatctacaaa tgaacaactt gaaaactgag gacactgccg tgtactactg tgtgagacat      360

gggaacttcg gtaatagcta cgtttcctgg tgggcttact ggggccaagg gactctggtc      420

accgtctcct cagctagcac caagggccca tccgtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

gcagctgggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccggaagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctgaagtc cgacggctcc ttcttcctct atagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aagcggccgc tggaggcggc     1440

ggttcaggcg gaggtggctc tcaggtgcag ctgcaggagt cgggcccagg actggtgaag     1500

ccttcacaga ccctgtccct cacctgcact gtctctggtg gctccatcag cagtggtgct     1560

tactactgga cctggatccg ccagcaccca gggaagggcc tggagtggat tgggtacatc     1620

tattacagtg ggagcaccta ctacaacccg tccctcaaga gtcgagttag catatcaata     1680

gacacgtcta agaaccagtt ctccctgaag ctgagctctg tgactgccgc ggacacggcc     1740

gtgtattact gtgcgcgagg cagcagcagc tggttcgact actggggcca gggaaccctg     1800

gtcaccgtct cctcagctag caccaagggc ccatccgtct tccccctggc accctcctcc     1860

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa     1920

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     1980

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     2040

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac     2100

aagagagttg agcccaaatc ttgt                                            2124


<210> 7
<211> 690
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
            100                 105                 110         


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
465                 470                 475                 480 


Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys 
                485                 490                 495     


Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln 
            500                 505                 510         


Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met 
        515                 520                 525             


Leu Ser Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
    530                 535                 540                 


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
545                 550                 555                 560 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly 
                565                 570                 575     


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
            580                 585                 590         


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
        595                 600                 605             


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
    610                 615                 620                 


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
625                 630                 635                 640 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
                645                 650                 655     


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
            660                 665                 670         


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
        675                 680                 685             


Cys Ser 
    690 


<210> 8
<211> 2070
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcccag       60

actgttgtga ctcaggaacc ttcactcacc gtatcacctg gtggaacagt cacactcact      120

tgtggctcct cgactggggc tgttacatct ggcaactacc caaactgggt ccaacaaaaa      180

ccaggtcagg caccccgtgg tctaataggt gggactaagt tcctcgcccc cggtactcct      240

gccagattct caggctccct gcttggaggc aaggctgccc tcaccctctc aggggtacag      300

ccagaggatg aggcagaata ttactgtgtt ctatggtaca gcaaccgctg ggtgttcggt      360

ggaggaacca aactgactgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt cagacaaaac tcacacatgc      720

ccaccgtgcc cagcacctga agcagctggg ggaccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacgacac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tatagcgagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaagcggccg ctggaggcgg cggttcaggc ggaggtggct ctcagtctgt gctgactcag     1440

ccaccctcgg tgtctgaagc ccccaggcag agggtcacca tctcctgttc tggaagcagc     1500

tccaacatcg gaaataatgc tgtaaactgg taccagcagc tcccaggaaa ggctcccaaa     1560

ctcctcatct attatgatga tatgttgtct tcaggggtct cggaccgatt ttctggctcc     1620

aagtctggca cctcagcctc cctggccatc agtgggctcc agtctgagga tgaggctgat     1680

tattactgtg cagcatggga tgacagcctg aatggtgtgg tattcggcgg agggaccaag     1740

ctgaccgtcc taggtcagcc caaggctgcc ccctcggtca ctctgttccc gccctcctct     1800

gaggagcttc aagccaacaa ggccacactg gtgtgtctca taagtgactt ctacccggga     1860

gccgtgacag tggcctggaa ggcagatagc agccccgtca aggcgggagt ggagaccacc     1920

acaccctcca aacaaagcaa caacaagtac gcggccagca gctatctgag cctgacgcct     1980

gagcagtgga agtcccacag aagctacagc tgccaggtca cgcatgaagg gagcaccgtg     2040

gagaagacag tggcccctac agaatgttca                                      2070


<210> 9
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys 
        35                  40                  45              


Ile Lys Asp Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr 
65                  70                  75                  80  


Gly Pro Asn Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser 
                85                  90                  95      


Asn Thr Gly Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                485                 490                 495     


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            500                 505                 510         


Asn Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        515                 520                 525             


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
    530                 535                 540                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
545                 550                 555                 560 


Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                565                 570                 575     


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
            580                 585                 590         


Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        595                 600                 605             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    610                 615                 620                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
625                 630                 635                 640 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                645                 650                 655     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            660                 665                 670         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        675                 680                 685             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    690                 695                 700                 


Arg Val Glu Pro Lys Ser Cys 
705                 710     


<210> 10
<211> 2133
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgc tcgagcagtc tggagctgag cttgtgaggc caggggcctt agtcaagttg      120

tcctgcaaag cttctggctt caaaattaaa gactactttg tgaactgggt gaagcagagg      180

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatgataa tagtttatat      240

ggcccgaact tccaggacaa ggccagtatc acagcagaca catcctccaa cacaggctac      300

ctgcagctca gcggcctgac atctgaggac actgccgtct attactgtgc tctttattac      360

ggaagtaggg gggatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      420

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc agctggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccggaaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctgaagtccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa gcggccgctg gaggcggcgg ttcaggcgga     1440

ggtggctctg aggtgcagct ggtcgagtct ggaggaggat tggtgcagcc tggagggtca     1500

ttgaaactct catgtgcagc ctctggattc accttcaata gctacgccat gaactgggtc     1560

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaagtaa atataataat     1620

tatgcaacat attatgccga ttcagtgaaa ggcaggttca ccatctccag agatgattca     1680

aaaaacactg cctatctaca aatgaacaac ttgaaaactg aggacactgc cgtgtactac     1740

tgtgtgagac atgggaactt cggtaatagc tacgtttcct ggtgggctta ctggggccaa     1800

gggactctgg tcaccgtctc ctcagctagc accaagggcc catccgtctt ccccctggca     1860

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac     1920

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc     1980

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc     2040

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc     2100

aaggtggaca agagagttga gcccaaatct tgt                                  2133


<210> 11
<211> 688
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Leu Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
465                 470                 475                 480 


Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
                485                 490                 495     


Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
            500                 505                 510         


Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
        515                 520                 525             


Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
    530                 535                 540                 


Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
545                 550                 555                 560 


Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                565                 570                 575     


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
            580                 585                 590         


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
        595                 600                 605             


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
    610                 615                 620                 


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
625                 630                 635                 640 


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
                645                 650                 655     


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
            660                 665                 670         


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        675                 680                 685             


<210> 12
<211> 2064
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

ctcgtgatga cccagactcc atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcaggg caagtcagga cattagcaat tatttaaact ggtatcagca gaaaccagat      180

ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggagcaagaa      300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgctcacgtt cggtgctggg      360

accaagcttg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg acaaaactca cacatgccca      720

ccgtgcccag cacctgaagc agctggggga ccgtcagtct tcctcttccc cccaaaaccc      780

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      840

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      900

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      960

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1020

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1080

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1140

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1200

gagaacaact acgacaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1260

agcgagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1320

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1380

gcggccgctg gaggcggcgg ttcaggcgga ggtggctctc agactgttgt gactcaggaa     1440

ccttcactca ccgtatcacc tggtggaaca gtcacactca cttgtggctc ctcgactggg     1500

gctgttacat ctggcaacta cccaaactgg gtccaacaaa aaccaggtca ggcaccccgt     1560

ggtctaatag gtgggactaa gttcctcgcc cccggtactc ctgccagatt ctcaggctcc     1620

ctgcttggag gcaaggctgc cctcaccctc tcaggggtac agccagagga tgaggcagaa     1680

tattactgtg ttctatggta cagcaaccgc tgggtgttcg gtggaggaac caaactgact     1740

gtcctaggtc agcccaaggc tgccccctcg gtcactctgt tcccgccctc ctctgaggag     1800

cttcaagcca acaaggccac actggtgtgt ctcataagtg acttctaccc gggagccgtg     1860

acagtggcct ggaaggcaga tagcagcccc gtcaaggcgg gagtggagac caccacaccc     1920

tccaaacaaa gcaacaacaa gtacgcggcc agcagctatc tgagcctgac gcctgagcag     1980

tggaagtccc acagaagcta cagctgccag gtcacgcatg aagggagcac cgtggagaag     2040

acagtggccc ctacagaatg ttca                                            2064


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Gly Gly Cys Val Phe Asn Met Phe Asn Cys Gly Gly 
1               5                   10          


<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Gly Cys His Leu Pro Phe Ala Val Cys Gly Gly 
1               5                   10          


<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Gly Gly Cys Gly His Glu Tyr Met Trp Cys Gly Gly 
1               5                   10          


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Gly Cys Trp Pro Leu Gln Asp Tyr Cys Gly Gly 
1               5                   10          


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Gly Gly Cys Met Gln Met Asn Lys Trp Cys Gly Gly 
1               5                   10          


<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Gly Cys Asp Gly Arg Thr Lys Tyr Cys Gly Gly 
1               5                   10          


<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Gly Cys Ala Leu Tyr Pro Thr Asn Cys Gly Gly 
1               5                   10          


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Cys Gly Lys His Trp His Gln Cys Gly Gly 
1               5                   10          


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Gly Cys His Ser Phe Lys His Phe Cys Gly Gly 
1               5                   10          


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gly Gly Cys Gln Gly Met Trp Thr Trp Cys Gly Gly 
1               5                   10          


<210> 23
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Gly Cys Ala Gln Gln Trp His His Glu Tyr Cys Gly Gly 
1               5                   10                  


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Gly Cys Glu Arg Phe His His Ala Cys Gly Gly 
1               5                   10          


<210> 25
<211> 91
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
1               5                   10                  15      


Ile Ser Trp Asp Ala Pro His His Gly Val Ala Tyr Tyr Arg Ile Thr 
            20                  25                  30          


Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro 
        35                  40                  45              


Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp 
    50                  55                  60                  


Tyr Thr Ile Asn Val Tyr Ala Val Leu Ala Tyr Pro Arg Gly Tyr Pro 
65                  70                  75                  80  


Leu Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90      


<210> 26
<211> 232
<212> PRT
<213> Homo sapiens

<400> 26
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 27
<211> 228
<212> PRT
<213> Homo sapiens

<400> 27
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 28
<211> 279
<212> PRT
<213> Homo sapiens

<400> 28
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210> 29
<211> 229
<212> PRT
<213> Homo sapiens

<400> 29
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(9)
<223> Any amino acid

<400> 30
Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Leu Glu Trp Ile Gly 
1               5   


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 32
Trp Gly Xaa Gly 
1               


<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 33
Phe Gly Xaa Gly 
1               


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Thr Val Ala Ala Pro 
1               5   


<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Ala Ser Thr Lys Gly Pro 
1               5       


<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 39
<211> 186
<212> PRT
<213> Homo sapiens

<400> 39
Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
            100                 105                 110         


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
        115                 120                 125             


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
    130                 135                 140                 


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
145                 150                 155                 160 


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
                165                 170                 175     


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185     


<210> 40
<211> 177
<212> PRT
<213> Macaca fascicularis

<400> 40
Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Ser Gln His Leu 
            20                  25                  30          


Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys Asn Lys Gly Asp Ser 
        35                  40                  45              


Gly Asp Gln Leu Phe Leu Pro Glu Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro Glu Asp Ala Ser His 
65                  70                  75                  80  


His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
                85                  90                  95      


Val Met Ala Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Leu 
            100                 105                 110         


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
        115                 120                 125             


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
    130                 135                 140                 


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro 
145                 150                 155                 160 


Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg 
                165                 170                 175     


Ile 
    


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Gln Asp Gly Asn Glu 
1               5   


<210> 42
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys 
        35                  40                  45              


Ile Lys Asp Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr 
65                  70                  75                  80  


Gly Pro Asn Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser 
                85                  90                  95      


Asn Thr Gly Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Ala Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
        515                 520                 525             


Gly Ser Ser His His His His His His 
    530                 535         


<210> 43
<211> 1611
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 43
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgc tcgagcagtc tggagctgag cttgtgaggc caggggcctt agtcaagttg      120

tcctgcaaag cttctggctt caaaattaaa gactactttg tgaactgggt gaagcagagg      180

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatgataa tagtttatat      240

ggcccgaact tccaggacaa ggccagtatc acagcagaca catcctccaa cacaggctac      300

ctgcagctca gcggcctgac atctgaggac actgccgtct attactgtgc tctttattac      360

ggaagtaggg gggatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgagct cgtgatgacc      480

cagactccat cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca      540

agtcaggaca ttagcaatta tttaaactgg tatcagcaga aaccagatgg aactgttaaa      600

ctcctgatct actacacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt      660

gggtctggaa cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact      720

tacttttgcc aacagggtaa tacgcttccg ctcacgttcg gtgctgggac caagcttgag      780

atcaaatccg gaggtggtgg atccgaggtg cagctggtcg agtctggagg aggattggtg      840

cagcctggag ggtcattgaa actctcatgt gcagcctctg gattcacctt caatagctac      900

gccatgaact gggtccgcca ggctccagga aagggtttgg aatgggttgc tcgcataaga      960

agtaaatata ataattatgc aacatattat gccgattcag tgaaaggcag gttcaccatc     1020

tccagagatg attcaaaaaa cactgcctat ctacaaatga acaacttgaa aactgaggac     1080

actgccgtgt actactgtgt gagacatggg aacttcggta atagctacgt ttcctggtgg     1140

gcttactggg gccaagggac tctggtcacc gtctcctcag gtggtggtgg ttctggcggc     1200

ggcggctccg gtggtggtgg ttctcagact gttgtgactc aggaaccttc actcaccgta     1260

tcacctggtg gaacagtcac actcacttgt ggctcctcga ctggggctgt tacatctggc     1320

aactacccaa actgggtcca acaaaaacca ggtcaggcac cccgtggtct aataggtggg     1380

actaagttcc tcgcccccgg tactcctgcc agattctcag gctccctgct tggaggcaag     1440

gctgccctca ccctctcagg ggtacagcca gaggatgagg cagaatatta ctgtgttcta     1500

tggtacagca accgctgggt gttcggtgga ggaaccaaac tgactgtcct agcggccgca     1560

gactacaaag acgatgacga caagggcagt tctcaccatc accatcacca c              1611


<210> 44
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Ala Tyr Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Ser Ile Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Ser Ser Ser Trp Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
145                 150                 155                 160 


Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly 
                165                 170                 175     


Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Met Leu Ser 
        195                 200                 205             


Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 
    210                 215                 220                 


Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Ala Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
        515                 520                 525             


Gly Ser Ser His His His His His His 
    530                 535         


<210> 45
<211> 1611
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 45
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cacagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagcagt ggtgcttact actggacctg gatccgccag      180

cacccaggga agggcctgga gtggattggg tacatctatt acagtgggag cacctactac      240

aacccgtccc tcaagagtcg agttagcata tcaatagaca cgtctaagaa ccagttctcc      300

ctgaagctga gctctgtgac tgccgcggac acggccgtgt attactgtgc gcgaggcagc      360

agcagctggt tcgactactg gggccaggga accctggtca ccgtctcctc aggaggcggc      420

ggttcaggcg gaggtggctc tggcggtggc ggaagtcagt ctgtgctgac tcagccaccc      480

tcggtgtctg aagcccccag gcagagggtc accatctcct gttctggaag cagctccaac      540

atcggaaata atgctgtaaa ctggtaccag cagctcccag gaaaggctcc caaactcctc      600

atctattatg atgatatgtt gtcttcaggg gtctcggacc gattttctgg ctccaagtct      660

ggcacctcag cctccctggc catcagtggg ctccagtctg aggatgaggc tgattattac      720

tgtgcagcat gggatgacag cctgaatggt gtggtattcg gcggagggac caagctgacc      780

gtcctatccg gaggtggtgg atccgaggtg cagctggtcg agtctggagg aggattggtg      840

cagcctggag ggtcattgaa actctcatgt gcagcctctg gattcacctt caatagctac      900

gccatgaact gggtccgcca ggctccagga aagggtttgg aatgggttgc tcgcataaga      960

agtaaatata ataattatgc aacatattat gccgattcag tgaaaggcag gttcaccatc     1020

tccagagatg attcaaaaaa cactgcctat ctacaaatga acaacttgaa aactgaggac     1080

actgccgtgt actactgtgt gagacatggg aacttcggta atagctacgt ttcctggtgg     1140

gcttactggg gccaagggac tctggtcacc gtctcctcag gtggtggtgg ttctggcggc     1200

ggcggctccg gtggtggtgg ttctcagact gttgtgactc aggaaccttc actcaccgta     1260

tcacctggtg gaacagtcac actcacttgt ggctcctcga ctggggctgt tacatctggc     1320

aactacccaa actgggtcca acaaaaacca ggtcaggcac cccgtggtct aataggtggg     1380

actaagttcc tcgcccccgg tactcctgcc agattctcag gctccctgct tggaggcaag     1440

gctgccctca ccctctcagg ggtacagcca gaggatgagg cagaatatta ctgtgttcta     1500

tggtacagca accgctgggt gttcggtgga ggaaccaaac tgactgtcct agcggccgca     1560

gactacaaag acgatgacga caagggcagt tctcaccatc accatcacca c              1611


<210> 46
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 
        115                 120                 125             


Ser Trp Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Gln Ser Gly 
                485                 490                 495     


Ala Glu Leu Val Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala 
            500                 505                 510         


Ser Gly Phe Lys Ile Lys Asp Tyr Phe Val Asn Trp Val Lys Gln Arg 
        515                 520                 525             


Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Asp 
    530                 535                 540                 


Asn Ser Leu Tyr Gly Pro Asn Phe Gln Asp Lys Ala Ser Ile Thr Ala 
545                 550                 555                 560 


Asp Thr Ser Ser Asn Thr Gly Tyr Leu Gln Leu Ser Gly Leu Thr Ser 
                565                 570                 575     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Tyr Tyr Gly Ser Arg Gly 
            580                 585                 590         


Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        595                 600                 605             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    610                 615                 620                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
625                 630                 635                 640 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                645                 650                 655     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            660                 665                 670         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        675                 680                 685             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    690                 695                 700                 


Arg Val Glu Pro Lys Ser Cys 
705                 710     


<210> 47
<211> 2133
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 47
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgg tcgagtctgg aggaggattg gtgcagcctg gagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatagc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaat ataataatta tgcaacatat      240

tatgccgatt cagtgaaagg caggttcacc atctccagag atgattcaaa aaacactgcc      300

tatctacaaa tgaacaactt gaaaactgag gacactgccg tgtactactg tgtgagacat      360

gggaacttcg gtaatagcta cgtttcctgg tgggcttact ggggccaagg gactctggtc      420

accgtctcct cagctagcac caagggccca tccgtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

gcagctgggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccggaagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctgaagtc cgacggctcc ttcttcctct atagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aagcggccgc tggaggcggc     1440

ggttcaggcg gaggtggctc tgaggtgcag ctgctcgagc agtctggagc tgagcttgtg     1500

aggccagggg ccttagtcaa gttgtcctgc aaagcttctg gcttcaaaat taaagactac     1560

tttgtgaact gggtgaagca gaggcctgaa cagggcctgg agtggattgg atggattgat     1620

cctgagaatg ataatagttt atatggcccg aacttccagg acaaggccag tatcacagca     1680

gacacatcct ccaacacagg ctacctgcag ctcagcggcc tgacatctga ggacactgcc     1740

gtctattact gtgctcttta ttacggaagt aggggggatg ctatggacta ctggggccaa     1800

gggaccacgg tcaccgtctc ctcagctagc accaagggcc catccgtctt ccccctggca     1860

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac     1920

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc     1980

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc     2040

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc     2100

aaggtggaca agagagttga gcccaaatct tgt                                  2133


<210> 48
<211> 688
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
            100                 105                 110         


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln 
465                 470                 475                 480 


Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                485                 490                 495     


Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            500                 505                 510         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
        515                 520                 525             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    530                 535                 540                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
545                 550                 555                 560 


Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly Thr 
                565                 570                 575     


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            580                 585                 590         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        595                 600                 605             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    610                 615                 620                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
625                 630                 635                 640 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
                645                 650                 655     


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
            660                 665                 670         


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        675                 680                 685             


<210> 49
<211> 2064
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgcccag       60

actgttgtga ctcaggaacc ttcactcacc gtatcacctg gtggaacagt cacactcact      120

tgtggctcct cgactggggc tgttacatct ggcaactacc caaactgggt ccaacaaaaa      180

ccaggtcagg caccccgtgg tctaataggt gggactaagt tcctcgcccc cggtactcct      240

gccagattct caggctccct gcttggaggc aaggctgccc tcaccctctc aggggtacag      300

ccagaggatg aggcagaata ttactgtgtt ctatggtaca gcaaccgctg ggtgttcggt      360

ggaggaacca aactgactgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt cagacaaaac tcacacatgc      720

ccaccgtgcc cagcacctga agcagctggg ggaccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacgacac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tatagcgagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaagcggccg ctggaggcgg cggttcaggc ggaggtggct ctgagctcgt gatgacccag     1440

actccatcct ccctgtctgc ctctctggga gacagagtca ccatcagttg cagggcaagt     1500

caggacatta gcaattattt aaactggtat cagcagaaac cagatggaac tgttaaactc     1560

ctgatctact acacatcaag attacactca ggagtcccat caaggttcag tggcagtggg     1620

tctggaacag attattctct caccattagc aacctggagc aagaagatat tgccacttac     1680

ttttgccaac agggtaatac gcttccgctc acgttcggtg ctgggaccaa gcttgagatc     1740

aaacgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa     1800

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta     1860

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag     1920

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac     1980

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca     2040

aagagcttca acaggggaga gtgt                                            2064


<210> 50
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (6)..(50)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(50)
<223> /note="This sequence may encompass 1-10 'Gly Gly Gly Gly Ser'
      repeating units"

<220>
<221> misc_feature
<222> (1)..(50)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Arg Arg Arg Arg Arg Arg 
1               5       


<210> 53
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Gly Gly Gly Gly Ser Arg Arg Arg Arg Arg Arg Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gly Gly Gly Gly Ser Gly Pro Leu Gly Ile Ala Gly Gln Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 55
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 56
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gln Ser Ser Arg His 
1               5                   10                  15      


Arg Arg Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 57
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Leu Gly Met 
1               5                   10                  15      


Leu Ser Gln Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 58
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Arg 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Ala Val Arg Trp Leu Leu Thr Ala 
1               5               


<210> 60
<211> 580
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
                245                 250                 255     


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
            260                 265                 270         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        275                 280                 285             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    290                 295                 300                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
305                 310                 315                 320 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
                325                 330                 335     


Asp Lys Thr Val Gly Gly Gly Gly Ser Ala Ala Ala Glu Pro Lys Ser 
            340                 345                 350         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        355                 360                 365             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    370                 375                 380                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
385                 390                 395                 400 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                405                 410                 415     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            420                 425                 430         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        435                 440                 445             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    450                 455                 460                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
465                 470                 475                 480 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                485                 490                 495     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            500                 505                 510         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro 
        515                 520                 525             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr 
    530                 535                 540                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
545                 550                 555                 560 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                565                 570                 575     


Ser Pro Gly Lys 
            580 


<210> 61
<211> 590
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys Ile Lys Asp 
            20                  25                  30          


Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr Gly Pro Asn 
    50                  55                  60                  


Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Gly 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
    130                 135                 140                 


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
145                 150                 155                 160 


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
        195                 200                 205             


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
    210                 215                 220                 


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
                245                 250                 255     


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            260                 265                 270         


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        275                 280                 285             


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    290                 295                 300                 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
305                 310                 315                 320 


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                325                 330                 335     


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Ala Ala Ala Glu Pro Lys 
            340                 345                 350         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        355                 360                 365             


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn Gln 
                485                 490                 495     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             


Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     


Leu Ser Pro Gly Lys Ala Ala Ala His His His His His His 
            580                 585                 590 


<210> 62
<211> 707
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys 
        35                  40                  45              


Ile Lys Asp Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr 
65                  70                  75                  80  


Gly Pro Asn Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser 
                85                  90                  95      


Asn Thr Gly Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Ala Ala Ala Arg Arg Arg Arg Arg Arg Glu 
465                 470                 475                 480 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                485                 490                 495     


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Ala 
            500                 505                 510         


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        515                 520                 525             


Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
    530                 535                 540                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
545                 550                 555                 560 


Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                565                 570                 575     


Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala 
            580                 585                 590         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        595                 600                 605             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    610                 615                 620                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
625                 630                 635                 640 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                645                 650                 655     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            660                 665                 670         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        675                 680                 685             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    690                 695                 700                 


Lys Ser Cys 
705         


<210> 63
<211> 2121
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 63
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgc tcgagcagtc tggagctgag cttgtgaggc caggggcctt agtcaagttg      120

tcctgcaaag cttctggctt caaaattaaa gactactttg tgaactgggt gaagcagagg      180

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatgataa tagtttatat      240

ggcccgaact tccaggacaa ggccagtatc acagcagaca catcctccaa cacaggctac      300

ctgcagctca gcggcctgac atctgaggac actgccgtct attactgtgc tctttattac      360

ggaagtaggg gggatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      420

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc agctggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccggaaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctgaagtccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa gcggccgctc ggcgaagacg tcgcagggag     1440

gtgcagctgg tcgagtctgg aggaggattg gtgcagcctg gagggtcatt gaaactctca     1500

tgtgcagcct ctggattcac cttcaatagc tacgccatga actgggtccg ccaggctcca     1560

ggaaagggtt tggaatgggt tgctcgcata agaagtaaat ataataatta tgcaacatat     1620

tatgccgatt cagtgaaagg caggttcacc atctccagag atgattcaaa aaacactgcc     1680

tatctacaaa tgaacaactt gaaaactgag gacactgccg tgtactactg tgtgagacat     1740

gggaacttcg gtaatagcta cgtttcctgg tgggcttact ggggccaagg gactctggtc     1800

accgtctcct cagctagcac caagggccca tccgtcttcc ccctggcacc ctcctccaag     1860

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg     1920

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc     1980

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg     2040

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag     2100

agagttgagc ccaaatcttg t                                               2121


<210> 64
<211> 709
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Gly Arg Ala Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Lys 
        35                  40                  45              


Ile Lys Asp Tyr Phe Val Asn Trp Val Lys Gln Arg Pro Glu Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Asp Asn Ser Leu Tyr 
65                  70                  75                  80  


Gly Pro Asn Phe Gln Asp Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser 
                85                  90                  95      


Asn Thr Gly Tyr Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Tyr Tyr Gly Ser Arg Gly Asp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly Pro Leu Gly Ile Ala Gly 
465                 470                 475                 480 


Gln Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                485                 490                 495     


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser 
            500                 505                 510         


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        515                 520                 525             


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
    530                 535                 540                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
545                 550                 555                 560 


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                565                 570                 575     


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp 
            580                 585                 590         


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        595                 600                 605             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    610                 615                 620                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
625                 630                 635                 640 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                645                 650                 655     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            660                 665                 670         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        675                 680                 685             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    690                 695                 700                 


Glu Pro Lys Ser Cys 
705                 


<210> 65
<211> 2127
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 65
atggggtcaa ccgccatcct tggcctcctc ctggctgtcc tgcagggagg gcgcgccgag       60

gtgcagctgc tcgagcagtc tggagctgag cttgtgaggc caggggcctt agtcaagttg      120

tcctgcaaag cttctggctt caaaattaaa gactactttg tgaactgggt gaagcagagg      180

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatgataa tagtttatat      240

ggcccgaact tccaggacaa ggccagtatc acagcagaca catcctccaa cacaggctac      300

ctgcagctca gcggcctgac atctgaggac actgccgtct attactgtgc tctttattac      360

ggaagtaggg gggatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      420

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc agctggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccggaaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctgaagtccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa gcggccgctg gaccgttggg tatcgctggc     1440

caggaggtgc agctggtcga gtctggagga ggattggtgc agcctggagg gtcattgaaa     1500

ctctcatgtg cagcctctgg attcaccttc aatagctacg ccatgaactg ggtccgccag     1560

gctccaggaa agggtttgga atgggttgct cgcataagaa gtaaatataa taattatgca     1620

acatattatg ccgattcagt gaaaggcagg ttcaccatct ccagagatga ttcaaaaaac     1680

actgcctatc tacaaatgaa caacttgaaa actgaggaca ctgccgtgta ctactgtgtg     1740

agacatggga acttcggtaa tagctacgtt tcctggtggg cttactgggg ccaagggact     1800

ctggtcaccg tctcctcagc tagcaccaag ggcccatccg tcttccccct ggcaccctcc     1860

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     1920

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     1980

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     2040

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg     2100

gacaagagag ttgagcccaa atcttgt                                         2127


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210> 67
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 68
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 68
gaggtgcagc tggtcgagtc tggaggagga ttggtgcagc ctggagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagtacgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aatataataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc aaaaaacact      240

gcctatctac aaatgaacaa cttgaaaact gaggacactg ccgtgtacta ctgtgtgaga      300

catgggaact tcggtaatag ctacatatcc tactgggctt actggggcca agggactctg      360

gtcaccgtct cctca                                                       375


<210> 69
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 70
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
cagactgttg tgactcagga accttcactc accgtatcac ctggtggaac agtcacactc       60

acttgtggct cctcgactgg ggctgttaca tctggcaact acccaaactg ggtccaacaa      120

aaaccaggtc aggcaccccg tggtctaata ggtgggacta agttcctcgc ccccggtact      180

cctgccagat tctcaggctc cctgcttgga ggcaaggctg ccctcaccct ctcaggggta      240

cagccagagg atgaggcaga atattactgt gttctatggt acagcaaccg ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210> 71
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Ala Pro Met Ala Glu Gly Gly Gly 
1               5               


<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Glu Ala Gln Gly Asp Lys Ile Ile 
1               5               


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Leu Ala Phe Ser Asp Ala Gly Pro 
1               5               


<210> 74
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Tyr Val Ala Asp Ala Pro Lys 
1               5           


<210> 75
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Ser Gly Arg Ser Ala 
1               5   


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Gly Ser Gly Arg Ser Ala 
1               5       


<210> 77
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Ser Gly Lys Ser Ala 
1               5   


<210> 78
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Ser Gly Arg Ser Ser 
1               5   


<210> 79
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Ser Gly Arg Arg Ala 
1               5   


<210> 80
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Ser Gly Arg Asn Ala 
1               5   


<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Ser Gly Arg Lys Ala 
1               5   


<210> 82
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 82
Gln Arg Gly Arg Ser Ala 
1               5       


<210> 83
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Thr Gln Gly Ala Ala Ala 
1               5       


<210> 84
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Gly Ala Ala Ala Ala Ala 
1               5       


<210> 85
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Gly Ala Gly Ala Ala Gly 
1               5       


<210> 86
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Ala Ala Ala Ala Ala Gly 
1               5       


<210> 87
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 87
Leu Cys Gly Ala Ala Ile 
1               5       


<210> 88
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Phe Ala Gln Ala Leu Gly 
1               5       


<210> 89
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Leu Leu Gln Ala Asn Pro 
1               5       


<210> 90
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 90
Leu Ala Ala Ala Asn Pro 
1               5       


<210> 91
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 91
Leu Tyr Gly Ala Gln Phe 
1               5       


<210> 92
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 92
Leu Ser Gln Ala Gln Gly 
1               5       


<210> 93
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 93
Ala Ser Ala Ala Ser Gly 
1               5       


<210> 94
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 94
Phe Leu Gly Ala Ser Leu 
1               5       


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 95
Ala Tyr Gly Ala Thr Gly 
1               5       


<210> 96
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Leu Ala Gln Ala Thr Gly 
1               5       


<210> 97
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 97
Arg Arg Arg Arg Arg 
1               5   


<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 98
Gly Gln Ser Ser Arg His Arg Arg Ala Leu 
1               5                   10  


<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 99
Gly Gly Pro Leu Gly Met Leu Ser Gln Ser 
1               5                   10  


<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Pro Leu Gly Leu Ala Gly 
1               5       


<210> 101
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 101
Leu Ala Ala Ala Asn Pro 
1               5       


