                         SEQUENCE LISTING

<110>  AGBAS, Abdulbaki
 
<120>  BIOMARKER FOR EARLY NEURODEGENERATION DETECTION

<130>  061237-462301PCT

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  4236
<212>  DNA
<213>  Homo sapiens

<400>  1
ggtgggcggg gggaggaggc ggccctagcg ccattttgtg ggagcgaagc ggtggctggg       60

ctgcgcttgg gtccgtcgct gcttcggtgt ccctgtcggg cttcccagca gcggcctagc      120

gggaaaagta aaagatgtct gaatatattc gggtaaccga agatgagaac gatgagccca      180

ttgaaatacc atcggaagac gatgggacgg tgctgctctc cacggttaca gcccagtttc      240

caggggcgtg tgggcttcgc tacaggaatc cagtgtctca gtgtatgaga ggtgtccggc      300

tggtagaagg aattctgcat gccccagatg ctggctgggg aaatctggtg tatgttgtca      360

actatccaaa agataacaaa agaaaaatgg atgagacaga tgcttcatca gcagtgaaag      420

tgaaaagagc agtccagaaa acatccgatt taatagtgtt gggtctccca tggaaaacaa      480

ccgaacagga cctgaaagag tattttagta cctttggaga agttcttatg gtgcaggtca      540

agaaagatct taagactggt cattcaaagg ggtttggctt tgttcgtttt acggaatatg      600

aaacacaagt gaaagtaatg tcacagcgac atatgataga tggacgatgg tgtgactgca      660

aacttcctaa ttctaagcaa agccaagatg agcctttgag aagcagaaaa gtgtttgtgg      720

ggcgctgtac agaggacatg actgaggatg agctgcggga gttcttctct cagtacgggg      780

atgtgatgga tgtcttcatc cccaagccat tcagggcctt tgcctttgtt acatttgcag      840

atgatcagat tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc      900

atatatccaa tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat      960

ttggtggtaa tccaggtggc tttgggaatc agggtggatt tggtaatagc agagggggtg     1020

gagctggttt gggaaacaat caaggtagta atatgggtgg tgggatgaac tttggtgcgt     1080

tcagcattaa tccagccatg atggctgccg cccaggcagc actacagagc agttggggta     1140

tgatgggcat gttagccagc cagcagaacc agtcaggccc atcgggtaat aaccaaaacc     1200

aaggcaacat gcagagggag ccaaaccagg ccttcggttc tggaaataac tcttatagtg     1260

gctctaattc tggtgcagca attggttggg gatcagcatc caatgcaggg tcgggcagtg     1320

gttttaatgg aggctttggc tcaagcatgg attctaagtc ttctggctgg ggaatgtaga     1380

cagtggggtt gtggttggtt ggtatagaat ggtgggaatt caaatttttc taaactcatg     1440

gtaagtatat tgtaaaatac atatgtacta agaattttca aaattggttt gttcagtgtg     1500

gagtatattc agcagtattt ttgacatttt tctttagaaa aaggaagagc taaaggaatt     1560

ttataagttt tgttacatga aaggttgaaa tattgagtgg ttgaaagtga actgctgttt     1620

gcctgattgg taaaccaaca cactacaatt gatatcaaaa ggtttctcct gtaatatttt     1680

atccctggac ttgtcaagtg aattctttgc atgttcaaaa cggaaaccat tgattagaac     1740

tacattcttt accccttgtt ttaatttgaa ccccaccata tggatttttt tccttaagaa     1800

aatctccttt taggagatca tggtgtcaca gtgtttggtt cttttgtttt gttttttaac     1860

acttgtctcc cctcatacac aaaagtacaa tatgaagcct tcatttaatc tctgcagttc     1920

atctcatttc aaatgtttat ggaagaagca cttcattgaa agtagtgctg taaatattct     1980

gccataggaa tactgtctac atgctttctc attcaagaat tcgtcatcac gcatcacagg     2040

ccgcgtcttt gacggtgggt gtcccatttt tatccgctac tctttatttc atggagtcgt     2100

atcaacgcta tgaacgcaag gctgtgatat ggaaccagaa ggctgtctga acttttgaaa     2160

ccttgtgtgg gattgatggt ggtgccgagg catgaaaggc tagtatgagc gagaaaagga     2220

gagagcgcgt gcagagactt ggtggtgcat aatggatatt ttttaacttg gcgagatgtg     2280

tctctcaatc ctgtggcttt ggtgagagag tgtgcagaga gcaatgatag caaataatgt     2340

acgaatgttt tttgcattca aaggacatcc acatctgttg gaagactttt aagtgagttt     2400

ttgttcttag ataacccaca ttagatgaat gtgttaagtg aaatgatact tgtactcccc     2460

ctaccccttt gtcaactgct gtgaatgctg tatggtgtgt gttctcttct gttactgata     2520

tgtaagtgtg gcaatgtgaa ctgaagctga tgggctgaga acatggactg agcttgtggt     2580

gtgctttgca ggaggacttg aagcagagtt caccagtgag ctcaggtgtc tcaaagaagg     2640

gtggaagttc taatgtctgt tagctaccca taagaatgct gtttgctgca gttctgtgtc     2700

ctgtgcttgg atgcttttta taagagttgt cattgttgga aattcttaaa taaaactgat     2760

ttaaataata tgtgtctttg ttttgcagcc ctgaatgcaa agaattcata gcagttaatt     2820

cccctttttt gacccttttg agatggaact ttcataaagt ttcttggcag tagtttattt     2880

tgcttcaaat aaacttattt gaaaagttgt ctcaagtcaa atggattcat cacctgtcat     2940

gcattgacac ctgataccca gacttaattg gtatttgttc ttgcattggc caaagtgaaa     3000

attttttttt ttcttttgaa atctagtttt gaataagtct gggtgaccgc acctaaaatg     3060

gtaagcagta ccctccggct ttttcttagt gcctctgtgc atttgggtga tgttctattt     3120

acatggcctg tgtaaatctc cattgggaag tcatgccttc taaaaagatt cttatttggg     3180

ggagtgggca aaatgttgat tattttctaa tgctttgtag caaagcatat caattgaaaa     3240

gggaatatca gcaccttcct agtttgggat ttgaaaagtg gaattaattg cagtagggat     3300

aaagtagaag aaaccacaaa ttatcttgtg cctgaaatcc attaagaggc ctgatagctt     3360

taagaattag ggtgggttgt ctgtctggaa gtgttaagtg gaatgggctt tgtcctccag     3420

gaggtggggg aatgtggtaa cattgaatac agttgaataa aatcgcttac aaaactcaca     3480

ctctcacaat gcattgttaa gtatgtaaaa gcaataacat tgattctctg ttgtactttt     3540

ttgtaactaa ttctgtgaga gttgagctca ttttctagtt ggaagaatgt gatatttgtt     3600

gtgttggtag tttacctaat gcccttacct aattagatta tgataaatag gtttgtcatt     3660

ttgcaagtta cataaacatt tatcaatgaa gtcatccttt agacttgtaa tcgccacatt     3720

gtttcattat tcagtttcct ctgtaaaggg atcttgagtt gttttaattt tttttttctg     3780

catctgaatc tgcatgattt ccaaaccctg taccatctga attttgcatt ttagcacttg     3840

cactattact cagcagcagt aacatggtaa cacttaaaat ggtactcggg gacctccaaa     3900

gactaaactg acaagccttc aaggagccca ggggtaagtt aacttgtcaa cggcatggtt     3960

taatcccttc tttacacttg tgtaaatttc agttactggt catagaaggc tttcaatgtt     4020

gagtggcctt ttattaacat gtttatggta ctgcatagat acgggtattt attttaccct     4080

aagaagattt tgaagtttaa aagtacttaa actatttggc aaagatttgt ttttaaaaat     4140

ctatttggtc aatctaaatg cattcattct aaaaaatttt ttgaaccaga taaataaaat     4200

ttttttttga caccacaaaa aaaaaaaaaa aaaaaa                               4236


<210>  2
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
1               5                   10      


