                         SEQUENCE LISTING

<110>  Drexel University
       Schlecht, Hans
       Vosseller, Keith
 
<120>  Novel Non-Invasive Methods of Monitoring HIV Viral Loads

<130>  046528-7030WO1(00519)

<150>  US 61/881,767
<151>  2013-09-24

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  4116
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Q8TD57

<400>  1

Met Gly Ala Thr Gly Arg Leu Glu Leu Thr Leu Ala Ala Pro Pro His 
1               5                   10                  15      


Pro Gly Pro Ala Phe Gln Arg Ser Lys Ala Arg Glu Thr Gln Gly Glu 
            20                  25                  30          


Glu Glu Gly Ser Glu Met Gln Ile Ala Lys Ser Asp Ser Ile His His 
        35                  40                  45              


Met Ser His Ser Gln Gly Gln Pro Glu Leu Pro Pro Leu Pro Ala Ser 
    50                  55                  60                  


Ala Asn Glu Glu Pro Ser Gly Leu Tyr Gln Thr Val Met Ser His Ser 
65                  70                  75                  80  


Phe Tyr Pro Pro Leu Met Gln Arg Thr Ser Trp Thr Leu Ala Ala Pro 
                85                  90                  95      


Phe Lys Glu Gln His His His Arg Gly Pro Ser Asp Ser Ile Ala Asn 
            100                 105                 110         


Asn Tyr Ser Leu Met Ala Gln Asp Leu Lys Leu Lys Asp Leu Leu Lys 
        115                 120                 125             


Val Tyr Gln Pro Ala Thr Ile Ser Val Pro Arg Asp Arg Thr Gly Gln 
    130                 135                 140                 


Gly Leu Pro Ser Ser Gly Asn Arg Ser Ser Ser Glu Pro Met Arg Lys 
145                 150                 155                 160 


Lys Thr Lys Phe Ser Ser Arg Asn Lys Glu Asp Ser Thr Arg Ile Lys 
                165                 170                 175     


Leu Ala Phe Lys Thr Ser Ile Phe Ser Pro Met Lys Lys Glu Val Lys 
            180                 185                 190         


Thr Ser Leu Thr Phe Pro Gly Ser Arg Pro Met Ser Pro Glu Gln Gln 
        195                 200                 205             


Leu Asp Val Met Leu Gln Gln Glu Met Glu Met Glu Ser Lys Glu Lys 
    210                 215                 220                 


Lys Pro Ser Glu Ser Asp Leu Glu Arg Tyr Tyr Tyr Tyr Leu Thr Asn 
225                 230                 235                 240 


Gly Ile Arg Lys Asp Met Ile Ala Pro Glu Glu Gly Glu Val Met Val 
                245                 250                 255     


Arg Ile Ser Lys Leu Ile Ser Asn Thr Leu Leu Thr Ser Pro Phe Leu 
            260                 265                 270         


Glu Pro Leu Met Val Val Leu Val Gln Glu Lys Glu Asn Asp Tyr Tyr 
        275                 280                 285             


Cys Ser Leu Met Lys Ser Ile Val Asp Tyr Ile Leu Met Asp Pro Met 
    290                 295                 300                 


Glu Arg Lys Arg Leu Phe Ile Glu Ser Ile Pro Arg Leu Phe Pro Gln 
305                 310                 315                 320 


Arg Val Ile Arg Ala Pro Val Pro Trp His Ser Val Tyr Arg Ser Ala 
                325                 330                 335     


Lys Lys Trp Asn Glu Glu His Leu His Thr Val Asn Pro Met Met Leu 
            340                 345                 350         


Arg Leu Lys Glu Leu Trp Phe Ala Glu Phe Arg Asp Leu Arg Phe Val 
        355                 360                 365             


Arg Thr Ala Glu Ile Leu Ala Gly Lys Leu Pro Leu Gln Pro Gln Glu 
    370                 375                 380                 


Phe Trp Asp Val Ile Gln Lys His Cys Leu Glu Ala His Gln Thr Leu 
385                 390                 395                 400 


Leu Asn Lys Trp Ile Pro Thr Cys Ala Gln Leu Phe Thr Ser Arg Lys 
                405                 410                 415     


Glu His Trp Ile His Phe Ala Pro Lys Ser Asn Tyr Asp Ser Ser Arg 
            420                 425                 430         


Asn Ile Glu Glu Tyr Phe Ala Ser Val Ala Ser Phe Met Ser Leu Gln 
        435                 440                 445             


Leu Arg Glu Leu Val Ile Lys Ser Leu Glu Asp Leu Val Ser Leu Phe 
    450                 455                 460                 


Met Ile His Lys Asp Gly Asn Asp Phe Lys Glu Pro Tyr Gln Glu Met 
465                 470                 475                 480 


Lys Phe Phe Ile Pro Gln Leu Ile Met Ile Lys Leu Glu Val Ser Glu 
                485                 490                 495     


Pro Ile Ile Val Phe Asn Pro Ser Phe Asp Gly Cys Trp Glu Leu Ile 
            500                 505                 510         


Arg Asp Ser Phe Leu Glu Ile Ile Lys Asn Ser Asn Gly Ile Pro Lys 
        515                 520                 525             


Leu Lys Tyr Ile Pro Leu Lys Phe Ser Phe Thr Ala Ala Ala Ala Asp 
    530                 535                 540                 


Arg Gln Cys Val Lys Ala Ala Glu Pro Gly Glu Pro Ser Met His Ala 
545                 550                 555                 560 


Ala Ala Thr Ala Met Ala Glu Leu Lys Gly Tyr Asn Leu Leu Leu Gly 
                565                 570                 575     


Thr Val Asn Ala Glu Glu Lys Leu Val Ser Asp Phe Leu Ile Gln Thr 
            580                 585                 590         


Phe Lys Val Phe Gln Lys Asn Gln Val Gly Pro Cys Lys Tyr Leu Asn 
        595                 600                 605             


Val Tyr Lys Lys Tyr Val Asp Leu Leu Asp Asn Thr Ala Glu Gln Asn 
    610                 615                 620                 


Ile Ala Ala Phe Leu Lys Glu Asn His Asp Ile Asp Asp Phe Val Thr 
625                 630                 635                 640 


Lys Ile Asn Ala Ile Lys Lys Arg Arg Asn Glu Ile Ala Ser Met Asn 
                645                 650                 655     


Ile Thr Val Pro Leu Ala Met Phe Cys Leu Asp Ala Thr Ala Leu Asn 
            660                 665                 670         


His Asp Leu Cys Glu Arg Ala Gln Asn Leu Lys Asp His Leu Ile Gln 
        675                 680                 685             


Phe Gln Val Asp Val Asn Arg Asp Thr Asn Thr Ser Ile Cys Asn Gln 
    690                 695                 700                 


Tyr Ser His Ile Ala Asp Lys Val Ser Glu Val Pro Ala Asn Thr Lys 
705                 710                 715                 720 


Glu Leu Val Ser Leu Ile Glu Phe Leu Lys Lys Ser Ser Ala Val Thr 
                725                 730                 735     


Val Phe Lys Leu Arg Arg Gln Leu Arg Asp Ala Ser Glu Arg Leu Glu 
            740                 745                 750         


Phe Leu Met Asp Tyr Ala Asp Leu Pro Tyr Gln Ile Glu Asp Ile Phe 
        755                 760                 765             


Asp Asn Ser Arg Asn Leu Leu Leu His Lys Arg Asp Gln Ala Glu Met 
    770                 775                 780                 


Asp Leu Ile Lys Arg Cys Ser Glu Phe Glu Leu Arg Leu Glu Gly Tyr 
785                 790                 795                 800 


His Arg Glu Leu Glu Ser Phe Arg Lys Arg Glu Val Met Thr Thr Glu 
                805                 810                 815     


Glu Met Lys His Asn Val Glu Lys Leu Asn Glu Leu Ser Lys Asn Leu 
            820                 825                 830         


Asn Arg Ala Phe Ala Glu Phe Glu Leu Ile Asn Lys Glu Glu Glu Leu 
        835                 840                 845             


Leu Glu Lys Glu Lys Ser Thr Tyr Pro Leu Leu Gln Ala Met Leu Lys 
    850                 855                 860                 


Asn Lys Val Pro Tyr Glu Gln Leu Trp Ser Thr Ala Tyr Glu Phe Ser 
865                 870                 875                 880 


Ile Lys Ser Glu Glu Trp Met Asn Gly Pro Leu Phe Leu Leu Asn Ala 
                885                 890                 895     


Glu Gln Ile Ala Glu Glu Ile Gly Asn Met Trp Arg Thr Thr Tyr Lys 
            900                 905                 910         


Leu Ile Lys Thr Leu Ser Asp Val Pro Ala Pro Arg Arg Leu Ala Glu 
        915                 920                 925             


Asn Val Lys Ile Lys Ile Asp Lys Phe Lys Gln Tyr Ile Pro Ile Leu 
    930                 935                 940                 


Ser Ile Ser Cys Asn Pro Gly Met Lys Asp Arg His Trp Gln Gln Ile 
945                 950                 955                 960 


Ser Glu Ile Val Gly Tyr Glu Ile Lys Pro Thr Glu Thr Thr Cys Leu 
                965                 970                 975     


Ser Asn Met Leu Glu Phe Gly Phe Gly Lys Phe Val Glu Lys Leu Glu 
            980                 985                 990         


Pro Ile Gly Ala Ala Ala Ser Lys  Glu Tyr Ser Leu Glu  Lys Asn Leu 
        995                 1000                 1005             


Asp Arg  Met Lys Leu Asp Trp  Val Asn Val Thr Phe  Ser Phe Val 
    1010                 1015                 1020             


Lys Tyr  Arg Asp Thr Asp Thr  Asn Ile Leu Cys Ala  Ile Asp Asp 
    1025                 1030                 1035             


Ile Gln  Met Leu Leu Asp Asp  His Val Ile Lys Thr  Gln Thr Met 
    1040                 1045                 1050             


Cys Gly  Ser Pro Phe Ile Lys  Pro Ile Glu Ala Glu  Cys Arg Lys 
    1055                 1060                 1065             


Trp Glu  Glu Lys Leu Ile Arg  Ile Gln Asp Asn Leu  Asp Ala Trp 
    1070                 1075                 1080             


Leu Lys  Cys Gln Ala Thr Trp  Leu Tyr Leu Glu Pro  Ile Phe Ser 
    1085                 1090                 1095             


Ser Glu  Asp Ile Ile Ala Gln  Met Pro Glu Glu Gly  Arg Lys Phe 
    1100                 1105                 1110             


Gly Ile  Val Asp Ser Tyr Trp  Lys Ser Leu Met Ser  Gln Ala Val 
    1115                 1120                 1125             


Lys Asp  Asn Arg Ile Leu Val  Ala Ala Asp Gln Pro  Arg Met Ala 
    1130                 1135                 1140             


Glu Lys  Leu Gln Glu Ala Asn  Phe Leu Leu Glu Asp  Ile Gln Lys 
    1145                 1150                 1155             


Gly Leu  Asn Asp Tyr Leu Glu  Lys Lys Arg Leu Phe  Phe Pro Arg 
    1160                 1165                 1170             


Phe Phe  Phe Leu Ser Asn Asp  Glu Leu Leu Glu Ile  Leu Ser Glu 
    1175                 1180                 1185             


Thr Lys  Asp Pro Leu Arg Val  Gln Pro His Leu Lys  Lys Cys Phe 
    1190                 1195                 1200             


Glu Gly  Ile Ala Lys Leu Glu  Phe Thr Asp Asn Leu  Glu Ile Val 
    1205                 1210                 1215             


Gly Met  Ile Ser Ser Glu Lys  Glu Thr Val Pro Phe  Ile Gln Lys 
    1220                 1225                 1230             


Ile Tyr  Pro Ala Asn Ala Lys  Gly Met Val Glu Lys  Trp Leu Gln 
    1235                 1240                 1245             


Gln Val  Glu Gln Met Met Leu  Ala Ser Met Arg Glu  Val Ile Gly 
    1250                 1255                 1260             


Leu Gly  Ile Glu Ala Tyr Val  Lys Val Pro Arg Asn  His Trp Val 
    1265                 1270                 1275             


Leu Gln  Trp Pro Gly Gln Val  Val Ile Cys Val Ser  Ser Ile Phe 
    1280                 1285                 1290             


Trp Thr  Gln Glu Val Ser Gln  Ala Leu Ala Glu Asn  Thr Leu Leu 
    1295                 1300                 1305             


Asp Phe  Leu Lys Lys Ser Asn  Asp Gln Ile Ala Gln  Ile Val Gln 
    1310                 1315                 1320             


Leu Val  Arg Gly Lys Leu Ser  Ser Gly Ala Arg Leu  Thr Leu Gly 
    1325                 1330                 1335             


Ala Leu  Thr Val Ile Asp Val  His Ala Arg Asp Val  Val Ala Lys 
    1340                 1345                 1350             


Leu Ser  Glu Asp Arg Val Ser  Asp Leu Asn Asp Phe  Gln Trp Ile 
    1355                 1360                 1365             


Ser Gln  Leu Arg Tyr Tyr Trp  Val Ala Lys Asp Val  Gln Val Gln 
    1370                 1375                 1380             


Ile Ile  Thr Thr Glu Ala Leu  Tyr Gly Tyr Glu Tyr  Leu Gly Asn 
    1385                 1390                 1395             


Ser Pro  Arg Leu Val Ile Thr  Pro Leu Thr Asp Arg  Cys Tyr Arg 
    1400                 1405                 1410             


Thr Leu  Met Gly Ala Leu Lys  Leu Asn Leu Gly Gly  Ala Pro Glu 
    1415                 1420                 1425             


Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Thr Thr Lys  Asp Leu Ala 
    1430                 1435                 1440             


Lys Ala  Leu Ala Lys Gln Cys  Val Val Phe Asn Cys  Ser Asp Gly 
    1445                 1450                 1455             


Leu Asp  Tyr Lys Ala Met Gly  Lys Phe Phe Lys Gly  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Ala Trp Ala Cys Phe  Asp Glu Phe Asn Arg  Ile Glu Val 
    1475                 1480                 1485             


Glu Val  Leu Ser Val Val Ala  Gln Gln Ile Leu Ser  Ile Gln Gln 
    1490                 1495                 1500             


Ala Ile  Ile Arg Lys Leu Lys  Thr Phe Ile Phe Glu  Gly Thr Glu 
    1505                 1510                 1515             


Leu Ser  Leu Asn Pro Thr Cys  Ala Val Phe Ile Thr  Met Asn Pro 
    1520                 1525                 1530             


Gly Tyr  Ala Gly Arg Ala Glu  Leu Pro Asp Asn Leu  Lys Ala Leu 
    1535                 1540                 1545             


Phe Arg  Thr Val Ala Met Met  Val Pro Asp Tyr Ala  Leu Ile Gly 
    1550                 1555                 1560             


Glu Ile  Ser Leu Tyr Ser Met  Gly Phe Leu Asp Ser  Arg Ser Leu 
    1565                 1570                 1575             


Ala Gln  Lys Ile Val Ala Thr  Tyr Arg Leu Cys Ser  Glu Gln Leu 
    1580                 1585                 1590             


Ser Ser  Gln His His Tyr Asp  Tyr Gly Met Arg Ala  Val Lys Ser 
    1595                 1600                 1605             


Val Leu  Thr Ala Ala Gly Asn  Leu Lys Leu Lys Tyr  Pro Glu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Val Leu Leu Leu  Arg Ala Leu Leu Asp  Val Asn Leu 
    1625                 1630                 1635             


Ala Lys  Phe Leu Ala Gln Asp  Val Pro Leu Phe Gln  Gly Ile Ile 
    1640                 1645                 1650             


Ser Asp  Leu Phe Pro Gly Val  Val Leu Pro Lys Pro  Asp Tyr Glu 
    1655                 1660                 1665             


Val Phe  Leu Lys Val Leu Asn  Asp Asn Ile Lys Lys  Met Lys Leu 
    1670                 1675                 1680             


Gln Pro  Val Pro Trp Phe Ile  Gly Lys Ile Ile Gln  Ile Tyr Glu 
    1685                 1690                 1695             


Met Met  Leu Val Arg His Gly  Tyr Met Ile Val Gly  Asp Pro Met 
    1700                 1705                 1710             


Gly Gly  Lys Thr Ser Ala Tyr  Lys Val Leu Ala Ala  Ala Leu Gly 
    1715                 1720                 1725             


Asp Leu  His Ala Ala Asn Gln  Met Glu Glu Phe Ala  Val Glu Tyr 
    1730                 1735                 1740             


Lys Ile  Ile Asn Pro Lys Ala  Ile Thr Met Gly Gln  Leu Tyr Gly 
    1745                 1750                 1755             


Cys Phe  Asp Gln Val Ser His  Glu Trp Met Asp Gly  Val Leu Ala 
    1760                 1765                 1770             


Asn Ala  Phe Arg Glu Gln Ala  Ser Ser Leu Ser Asp  Asp Arg Lys 
    1775                 1780                 1785             


Trp Ile  Ile Phe Asp Gly Pro  Val Asp Ala Ile Trp  Ile Glu Asn 
    1790                 1795                 1800             


Met Asn  Thr Val Leu Asp Asp  Asn Lys Lys Leu Cys  Leu Met Ser 
    1805                 1810                 1815             


Gly Glu  Ile Ile Gln Met Asn  Ser Lys Met Ser Leu  Ile Phe Glu 
    1820                 1825                 1830             


Pro Ala  Asp Leu Glu Gln Ala  Ser Pro Ala Thr Val  Ser Arg Cys 
    1835                 1840                 1845             


Gly Met  Ile Tyr Met Glu Pro  His Gln Leu Gly Trp  Lys Pro Leu 
    1850                 1855                 1860             


Lys Asp  Ser Tyr Met Asp Thr  Leu Pro Ser Ser Leu  Thr Lys Glu 
    1865                 1870                 1875             


His Lys  Glu Leu Val Asn Asp  Met Phe Met Trp Leu  Val Gln Pro 
    1880                 1885                 1890             


Cys Leu  Glu Phe Gly Arg Leu  His Cys Lys Phe Val  Val Gln Thr 
    1895                 1900                 1905             


Ser Pro  Ile His Leu Ala Phe  Ser Met Met Arg Leu  Tyr Ser Ser 
    1910                 1915                 1920             


Leu Leu  Asp Glu Ile Arg Ala  Val Glu Glu Glu Glu  Met Glu Leu 
    1925                 1930                 1935             


Gly Glu  Gly Leu Ser Ser Gln  Gln Ile Phe Leu Trp  Leu Gln Gly 
    1940                 1945                 1950             


Leu Phe  Leu Phe Ser Leu Val  Trp Thr Val Ala Gly  Thr Ile Asn 
    1955                 1960                 1965             


Ala Asp  Ser Arg Lys Lys Phe  Asp Val Phe Phe Arg  Asn Leu Ile 
    1970                 1975                 1980             


Met Gly  Met Asp Asp Asn His  Pro Arg Pro Lys Ser  Val Lys Leu 
    1985                 1990                 1995             


Thr Lys  Asn Asn Ile Phe Pro  Glu Arg Gly Ser Ile  Tyr Asp Phe 
    2000                 2005                 2010             


Tyr Phe  Ile Lys Gln Ala Ser  Gly His Trp Glu Thr  Trp Thr Gln 
    2015                 2020                 2025             


Tyr Ile  Thr Lys Glu Glu Glu  Lys Val Pro Ala Gly  Ala Lys Val 
    2030                 2035                 2040             


Ser Glu  Leu Ile Ile Pro Thr  Met Glu Thr Ala Arg  Gln Ser Phe 
    2045                 2050                 2055             


Phe Leu  Lys Thr Tyr Leu Asp  His Glu Ile Pro Met  Leu Phe Val 
    2060                 2065                 2070             


Gly Pro  Thr Gly Thr Gly Lys  Ser Ala Ile Thr Asn  Asn Phe Leu 
    2075                 2080                 2085             


Leu His  Leu Pro Lys Asn Thr  Tyr Leu Pro Asn Cys  Ile Asn Phe 
    2090                 2095                 2100             


Ser Ala  Arg Thr Ser Ala Asn  Gln Thr Gln Asp Ile  Ile Met Ser 
    2105                 2110                 2115             


Lys Leu  Asp Arg Arg Arg Lys  Gly Leu Phe Gly Pro  Pro Ile Gly 
    2120                 2125                 2130             


Lys Lys  Ala Val Val Phe Val  Asp Asp Leu Asn Met  Pro Ala Lys 
    2135                 2140                 2145             


Glu Val  Tyr Gly Ala Gln Pro  Pro Ile Glu Leu Leu  Arg Gln Trp 
    2150                 2155                 2160             


Ile Asp  His Gly Tyr Trp Phe  Asp Lys Lys Asp Thr  Thr Arg Leu 
    2165                 2170                 2175             


Asp Ile  Val Asp Met Leu Leu  Val Thr Ala Met Gly  Pro Pro Gly 
    2180                 2185                 2190             


Gly Gly  Arg Asn Asp Ile Thr  Gly Arg Phe Thr Arg  His Leu Asn 
    2195                 2200                 2205             


Ile Ile  Ser Ile Asn Ala Phe  Glu Asp Asp Ile Leu  Thr Lys Ile 
    2210                 2215                 2220             


Phe Ser  Ser Ile Val Asp Trp  His Phe Gly Lys Gly  Phe Asp Val 
    2225                 2230                 2235             


Met Phe  Leu Arg Tyr Gly Lys  Met Leu Val Gln Ala  Thr Lys Thr 
    2240                 2245                 2250             


Ile Tyr  Arg Asp Ala Val Glu  Asn Phe Leu Pro Thr  Pro Ser Lys 
    2255                 2260                 2265             


Ser His  Tyr Val Phe Asn Leu  Arg Asp Phe Ser Arg  Val Ile Gln 
    2270                 2275                 2280             


Gly Val  Leu Leu Cys Pro His  Thr His Leu Gln Asp  Val Glu Lys 
    2285                 2290                 2295             


Cys Ile  Arg Leu Trp Ile His  Glu Val Tyr Arg Val  Phe Tyr Asp 
    2300                 2305                 2310             


Arg Leu  Ile Asp Lys Glu Asp  Arg Gln Val Phe Phe  Asn Met Val 
    2315                 2320                 2325             


Lys Glu  Thr Thr Ser Asn Cys  Phe Lys Gln Thr Ile  Glu Lys Val 
    2330                 2335                 2340             


Leu Ile  His Leu Ser Pro Thr  Gly Lys Ile Val Asp  Asp Asn Ile 
    2345                 2350                 2355             


Arg Ser  Leu Phe Phe Gly Asp  Tyr Phe Lys Pro Glu  Ser Asp Gln 
    2360                 2365                 2370             


Lys Ile  Tyr Asp Glu Ile Thr  Asp Leu Lys Gln Leu  Thr Val Val 
    2375                 2380                 2385             


Met Glu  His Tyr Leu Glu Glu  Phe Asn Asn Ile Ser  Lys Ala Pro 
    2390                 2395                 2400             


Met Ser  Leu Val Met Phe Arg  Phe Ala Ile Glu His  Ile Ser Arg 
    2405                 2410                 2415             


Ile Cys  Arg Val Leu Lys Gln  Asp Lys Gly His Leu  Leu Leu Val 
    2420                 2425                 2430             


Gly Ile  Gly Gly Ser Gly Arg  Gln Ser Ala Ala Lys  Leu Ser Thr 
    2435                 2440                 2445             


Phe Met  Asn Ala Tyr Glu Leu  Tyr Gln Ile Glu Ile  Thr Lys Asn 
    2450                 2455                 2460             


Tyr Ala  Gly Asn Asp Trp Arg  Glu Asp Leu Lys Lys  Ile Ile Leu 
    2465                 2470                 2475             


Gln Val  Gly Val Ala Thr Lys  Ser Thr Val Phe Leu  Phe Ala Asp 
    2480                 2485                 2490             


Asn Gln  Ile Lys Asp Glu Ser  Phe Val Glu Asp Ile  Asn Met Leu 
    2495                 2500                 2505             


Leu Asn  Thr Gly Asp Val Pro  Asn Ile Phe Pro Ala  Asp Glu Lys 
    2510                 2515                 2520             


Ala Asp  Ile Val Glu Lys Met  Gln Thr Ala Ala Arg  Thr Gln Gly 
    2525                 2530                 2535             


Glu Lys  Val Glu Val Thr Pro  Leu Ser Met Tyr Asn  Phe Phe Ile 
    2540                 2545                 2550             


Glu Arg  Val Ile Asn Lys Ile  Ser Phe Ser Leu Ala  Met Ser Pro 
    2555                 2560                 2565             


Ile Gly  Asp Ala Phe Arg Asn  Arg Leu Arg Met Phe  Pro Ser Leu 
    2570                 2575                 2580             


Ile Asn  Cys Cys Thr Ile Asp  Trp Phe Gln Ser Trp  Pro Thr Asp 
    2585                 2590                 2595             


Ala Leu  Glu Leu Val Ala Asn  Lys Phe Leu Glu Asp  Val Glu Leu 
    2600                 2605                 2610             


Asp Asp  Asn Ile Arg Val Glu  Val Val Ser Met Cys  Lys Tyr Phe 
    2615                 2620                 2625             


Gln Glu  Ser Val Lys Lys Leu  Ser Leu Asp Tyr Tyr  Asn Lys Leu 
    2630                 2635                 2640             


Arg Arg  His Asn Tyr Val Thr  Pro Thr Ser Tyr Leu  Glu Leu Ile 
    2645                 2650                 2655             


Leu Thr  Phe Lys Thr Leu Leu  Asn Ser Lys Arg Gln  Glu Val Ala 
    2660                 2665                 2670             


Met Met  Arg Asn Arg Tyr Leu  Thr Gly Leu Gln Lys  Leu Asp Phe 
    2675                 2680                 2685             


Ala Ala  Ser Gln Val Ala Val  Met Gln Arg Glu Leu  Thr Ala Leu 
    2690                 2695                 2700             


Gln Pro  Gln Leu Ile Leu Thr  Ser Glu Glu Thr Ala  Lys Met Met 
    2705                 2710                 2715             


Val Lys  Ile Glu Ala Glu Thr  Arg Glu Ala Asp Gly  Lys Lys Leu 
    2720                 2725                 2730             


Leu Val  Gln Ala Asp Glu Lys  Glu Ala Asn Val Ala  Ala Ala Ile 
    2735                 2740                 2745             


Ala Gln  Gly Ile Lys Asn Glu  Cys Glu Gly Asp Leu  Ala Glu Ala 
    2750                 2755                 2760             


Met Pro  Ala Leu Glu Ala Ala  Leu Ala Ala Leu Asp  Thr Leu Asn 
    2765                 2770                 2775             


Pro Ala  Asp Ile Ser Leu Val  Lys Ser Met Gln Asn  Pro Pro Gly 
    2780                 2785                 2790             


Pro Val  Lys Leu Val Met Glu  Ser Ile Cys Ile Met  Lys Gly Met 
    2795                 2800                 2805             


Lys Pro  Glu Arg Lys Pro Asp  Pro Ser Gly Ser Gly  Lys Met Ile 
    2810                 2815                 2820             


Glu Asp  Tyr Trp Gly Val Ser  Lys Lys Ile Leu Gly  Asp Leu Lys 
    2825                 2830                 2835             


Phe Leu  Glu Ser Leu Lys Thr  Tyr Asp Lys Asp Asn  Ile Pro Pro 
    2840                 2845                 2850             


Leu Thr  Met Lys Arg Ile Arg  Glu Arg Phe Ile Asn  His Pro Glu 
    2855                 2860                 2865             


Phe Gln  Pro Ala Val Ile Lys  Asn Val Ser Ser Ala  Cys Glu Gly 
    2870                 2875                 2880             


Leu Cys  Lys Trp Val Arg Ala  Met Glu Val Tyr Asp  Arg Val Ala 
    2885                 2890                 2895             


Lys Val  Val Ala Pro Lys Arg  Glu Arg Leu Arg Glu  Ala Glu Gly 
    2900                 2905                 2910             


Lys Leu  Ala Ala Gln Met Gln  Lys Leu Asn Gln Lys  Arg Ala Glu 
    2915                 2920                 2925             


Leu Lys  Leu Val Val Asp Arg  Leu Gln Ala Leu Asn  Asp Asp Phe 
    2930                 2935                 2940             


Glu Glu  Met Asn Thr Lys Lys  Lys Asp Leu Glu Glu  Asn Ile Glu 
    2945                 2950                 2955             


Ile Cys  Ser Gln Lys Leu Val  Arg Ala Glu Lys Leu  Ile Ser Gly 
    2960                 2965                 2970             


Leu Gly  Gly Glu Lys Asp Arg  Trp Thr Glu Ala Ala  Arg Gln Leu 
    2975                 2980                 2985             


Gly Ile  Arg Tyr Thr Asn Leu  Thr Gly Asp Val Leu  Leu Ser Ser 
    2990                 2995                 3000             


Gly Thr  Val Ala Tyr Leu Gly  Ala Phe Thr Val Asp  Tyr Arg Val 
    3005                 3010                 3015             


Gln Cys  Gln Asn Gln Trp Leu  Ala Glu Cys Lys Asp  Lys Val Ile 
    3020                 3025                 3030             


Pro Gly  Phe Ser Asp Phe Ser  Leu Ser His Thr Leu  Gly Asp Pro 
    3035                 3040                 3045             


Ile Lys  Ile Arg Ala Trp Gln  Ile Ala Gly Leu Pro  Val Asp Ser 
    3050                 3055                 3060             


Phe Ser  Ile Asp Asn Gly Ile  Ile Val Ser Asn Ser  Arg Arg Trp 
    3065                 3070                 3075             


Ala Leu  Met Ile Asp Pro His  Gly Gln Ala Asn Lys  Trp Ile Lys 
    3080                 3085                 3090             


Asn Met  Glu Lys Ala Asn Lys  Leu Ala Val Ile Lys  Phe Ser Asp 
    3095                 3100                 3105             


Ser Asn  Tyr Met Arg Met Leu  Glu Asn Ala Leu Gln  Leu Gly Thr 
    3110                 3115                 3120             


Pro Val  Leu Ile Glu Asn Ile  Gly Glu Glu Leu Asp  Ala Ser Ile 
    3125                 3130                 3135             


Glu Pro  Ile Leu Leu Lys Ala  Thr Phe Lys Gln Gln  Gly Val Glu 
    3140                 3145                 3150             


Tyr Met  Arg Leu Gly Glu Asn  Ile Ile Glu Tyr Ser  Arg Asp Phe 
    3155                 3160                 3165             


Lys Leu  Tyr Ile Thr Thr Arg  Leu Arg Asn Pro His  Tyr Leu Pro 
    3170                 3175                 3180             


Glu Val  Ala Val Lys Val Cys  Leu Leu Asn Phe Met  Ile Thr Pro 
    3185                 3190                 3195             


Leu Gly  Leu Gln Asp Gln Leu  Leu Gly Ile Val Ala  Ala Lys Glu 
    3200                 3205                 3210             


Lys Pro  Glu Leu Glu Glu Lys  Lys Asn Gln Leu Ile  Val Glu Ser 
    3215                 3220                 3225             


Ala Lys  Asn Lys Lys His Leu  Lys Glu Ile Glu Asp  Lys Ile Leu 
    3230                 3235                 3240             


Glu Val  Leu Ser Met Ser Lys  Gly Asn Ile Leu Glu  Asp Glu Thr 
    3245                 3250                 3255             


Ala Ile  Lys Val Leu Ser Ser  Ser Lys Val Leu Ser  Glu Glu Ile 
    3260                 3265                 3270             


Ser Glu  Lys Gln Lys Val Ala  Ser Met Thr Glu Thr  Gln Ile Asp 
    3275                 3280                 3285             


Glu Thr  Arg Met Gly Tyr Lys  Pro Val Ala Val His  Ser Ala Thr 
    3290                 3295                 3300             


Ile Phe  Phe Cys Ile Ser Asp  Leu Ala Asn Ile Glu  Pro Met Tyr 
    3305                 3310                 3315             


Gln Tyr  Ser Leu Thr Trp Phe  Ile Asn Leu Tyr Met  His Ser Leu 
    3320                 3325                 3330             


Thr His  Ser Thr Lys Ser Glu  Glu Leu Asn Leu Arg  Ile Lys Tyr 
    3335                 3340                 3345             


Ile Ile  Asp His Phe Thr Leu  Ser Ile Tyr Asn Asn  Val Cys Arg 
    3350                 3355                 3360             


Ser Leu  Phe Glu Lys Asp Lys  Leu Leu Phe Ser Leu  Leu Leu Thr 
    3365                 3370                 3375             


Ile Gly  Ile Met Lys Gln Lys  Lys Glu Ile Thr Glu  Glu Val Trp 
    3380                 3385                 3390             


Tyr Phe  Leu Leu Thr Gly Gly  Ile Ala Leu Asp Asn  Pro Tyr Pro 
    3395                 3400                 3405             


Asn Pro  Ala Pro Gln Trp Leu  Ser Glu Lys Ala Trp  Ala Glu Ile 
    3410                 3415                 3420             


Val Arg  Ala Ser Ala Leu Pro  Lys Leu His Gly Leu  Met Glu His 
    3425                 3430                 3435             


Leu Glu  Gln Asn Leu Gly Glu  Trp Lys Leu Ile Tyr  Asp Ser Ala 
    3440                 3445                 3450             


Trp Pro  His Glu Glu Gln Leu  Pro Gly Ser Trp Lys  Phe Ser Gln 
    3455                 3460                 3465             


Gly Leu  Glu Lys Met Val Ile  Leu Arg Cys Leu Arg  Pro Asp Lys 
    3470                 3475                 3480             


Met Val  Pro Ala Val Arg Glu  Phe Ile Ala Glu His  Met Gly Lys 
    3485                 3490                 3495             


Leu Tyr  Ile Glu Ala Pro Thr  Phe Asp Leu Gln Gly  Ser Tyr Asn 
    3500                 3505                 3510             


Asp Ser  Ser Cys Cys Ala Pro  Leu Ile Phe Val Leu  Ser Pro Ser 
    3515                 3520                 3525             


Ala Asp  Pro Met Ala Gly Leu  Leu Lys Phe Ala Asp  Asp Leu Gly 
    3530                 3535                 3540             


Met Gly  Gly Thr Arg Thr Gln  Thr Ile Ser Leu Gly  Gln Gly Gln 
    3545                 3550                 3555             


Gly Pro  Ile Ala Ala Lys Met  Ile Asn Asn Ala Ile  Lys Asp Gly 
    3560                 3565                 3570             


Thr Trp  Val Val Leu Gln Asn  Cys His Leu Ala Ala  Ser Trp Met 
    3575                 3580                 3585             


Pro Thr  Leu Glu Lys Ile Cys  Glu Glu Val Ile Val  Pro Glu Ser 
    3590                 3595                 3600             


Thr Asn  Ala Arg Phe Arg Leu  Trp Leu Thr Ser Tyr  Pro Ser Glu 
    3605                 3610                 3615             


Lys Phe  Pro Val Ser Ile Leu  Gln Asn Gly Ile Lys  Met Thr Asn 
    3620                 3625                 3630             


Glu Pro  Pro Lys Gly Leu Arg  Ala Asn Leu Leu Arg  Ser Tyr Leu 
    3635                 3640                 3645             


Asn Asp  Pro Ile Ser Asp Pro  Val Phe Phe Gln Ser  Cys Ala Lys 
    3650                 3655                 3660             


Ala Val  Met Trp Gln Lys Met  Leu Phe Gly Leu Cys  Phe Phe His 
    3665                 3670                 3675             


Ala Val  Val Gln Glu Arg Arg  Asn Phe Gly Pro Leu  Gly Trp Asn 
    3680                 3685                 3690             


Ile Pro  Tyr Glu Phe Asn Glu  Ser Asp Leu Arg Ile  Ser Met Trp 
    3695                 3700                 3705             


Gln Ile  Gln Met Phe Leu Asn  Asp Tyr Lys Glu Val  Pro Phe Asp 
    3710                 3715                 3720             


Ala Leu  Thr Tyr Leu Thr Gly  Glu Cys Asn Tyr Gly  Gly Arg Val 
    3725                 3730                 3735             


Thr Asp  Asp Lys Asp Arg Arg  Leu Leu Leu Ser Leu  Leu Ser Met 
    3740                 3745                 3750             


Phe Tyr  Cys Lys Glu Ile Glu  Glu Asp Tyr Tyr Ser  Leu Ala Pro 
    3755                 3760                 3765             


Gly Asp  Thr Tyr Tyr Ile Pro  Pro His Gly Ser Tyr  Gln Ser Tyr 
    3770                 3775                 3780             


Ile Asp  Tyr Leu Arg Asn Leu  Pro Ile Thr Ala His  Pro Glu Val 
    3785                 3790                 3795             


Phe Gly  Leu His Glu Asn Ala  Asp Ile Thr Lys Asp  Asn Gln Glu 
    3800                 3805                 3810             


Thr Asn  Gln Leu Phe Glu Gly  Val Leu Leu Thr Leu  Pro Arg Gln 
    3815                 3820                 3825             


Ser Gly  Gly Ser Gly Lys Ser  Pro Gln Glu Val Val  Glu Glu Leu 
    3830                 3835                 3840             


Ala Gln  Asp Ile Leu Ser Lys  Leu Pro Arg Asp Phe  Asp Leu Glu 
    3845                 3850                 3855             


Glu Val  Met Lys Leu Tyr Pro  Val Val Tyr Glu Glu  Ser Met Asn 
    3860                 3865                 3870             


Thr Val  Leu Arg Gln Glu Leu  Ile Arg Phe Asn Arg  Leu Thr Lys 
    3875                 3880                 3885             


Val Val  Arg Arg Ser Leu Ile  Asn Leu Gly Arg Ala  Ile Lys Gly 
    3890                 3895                 3900             


Gln Val  Leu Met Ser Ser Glu  Leu Glu Glu Val Phe  Asn Ser Met 
    3905                 3910                 3915             


Leu Val  Gly Lys Val Pro Ala  Met Trp Ala Ala Lys  Ser Tyr Pro 
    3920                 3925                 3930             


Ser Leu  Lys Pro Leu Gly Gly  Tyr Val Ala Asp Leu  Leu Ala Arg 
    3935                 3940                 3945             


Leu Thr  Phe Phe Gln Glu Trp  Ile Asp Lys Gly Pro  Pro Val Val 
    3950                 3955                 3960             


Phe Trp  Ile Ser Gly Phe Tyr  Phe Thr Gln Ser Phe  Leu Thr Gly 
    3965                 3970                 3975             


Val Ser  Gln Asn Tyr Ala Arg  Lys Tyr Thr Ile Pro  Ile Asp His 
    3980                 3985                 3990             


Ile Gly  Phe Glu Phe Glu Val  Thr Pro Gln Glu Thr  Val Met Glu 
    3995                 4000                 4005             


Asn Asn  Pro Glu Asp Gly Ala  Tyr Ile Lys Gly Leu  Phe Leu Glu 
    4010                 4015                 4020             


Gly Ala  Arg Trp Asp Arg Lys  Thr Met Gln Ile Gly  Glu Ser Leu 
    4025                 4030                 4035             


Pro Lys  Ile Leu Tyr Asp Pro  Leu Pro Ile Ile Trp  Leu Lys Pro 
    4040                 4045                 4050             


Gly Glu  Ser Ala Met Phe Leu  His Gln Asp Ile Tyr  Val Cys Pro 
    4055                 4060                 4065             


Val Tyr  Lys Thr Ser Ala Arg  Arg Gly Thr Leu Ser  Thr Thr Gly 
    4070                 4075                 4080             


His Ser  Thr Asn Tyr Val Leu  Ser Ile Glu Leu Pro  Thr Asp Met 
    4085                 4090                 4095             


Pro Gln  Lys His Trp Ile Asn  Arg Gly Val Ala Ser  Leu Cys Gln 
    4100                 4105                 4110             


Leu Asp  Asn 
    4115     


<210>  2
<211>  504
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q18PE1

<400>  2

Met Thr Glu Ala Ala Leu Val Glu Gly Gln Val Lys Leu Arg Asp Gly 
1               5                   10                  15      


Lys Lys Trp Lys Ser Arg Trp Leu Val Leu Arg Lys Pro Ser Pro Val 
            20                  25                  30          


Ala Asp Cys Leu Leu Met Leu Val Tyr Lys Asp Lys Ser Glu Arg Ile 
        35                  40                  45              


Lys Gly Leu Arg Glu Arg Ser Ser Leu Thr Leu Glu Asp Ile Cys Gly 
    50                  55                  60                  


Leu Glu Pro Gly Leu Pro Tyr Glu Gly Leu Val His Thr Leu Ala Ile 
65                  70                  75                  80  


Val Cys Leu Ser Gln Ala Ile Met Leu Gly Phe Asp Ser His Glu Ala 
                85                  90                  95      


Met Cys Ala Trp Asp Ala Arg Ile Arg Tyr Ala Leu Gly Glu Val His 
            100                 105                 110         


Arg Phe His Val Thr Val Ala Pro Gly Thr Lys Leu Glu Ser Gly Pro 
        115                 120                 125             


Ala Thr Leu His Leu Cys Asn Asp Val Leu Val Leu Ala Arg Asp Ile 
    130                 135                 140                 


Pro Pro Ala Val Thr Gly Gln Trp Lys Leu Ser Asp Leu Arg Arg Tyr 
145                 150                 155                 160 


Gly Ala Val Pro Ser Gly Phe Ile Phe Glu Gly Gly Thr Arg Cys Gly 
                165                 170                 175     


Tyr Trp Ala Gly Val Phe Phe Leu Ser Ser Ala Glu Gly Glu Gln Ile 
            180                 185                 190         


Ser Phe Leu Phe Asp Cys Ile Val Arg Gly Ile Ser Pro Thr Lys Gly 
        195                 200                 205             


Pro Phe Gly Leu Arg Pro Val Leu Pro Asp Pro Ser Pro Pro Gly Pro 
    210                 215                 220                 


Ser Thr Val Glu Glu Arg Val Ala Gln Glu Ala Leu Glu Thr Leu Gln 
225                 230                 235                 240 


Leu Glu Lys Arg Leu Ser Leu Leu Ser His Ala Gly Arg Pro Gly Ser 
                245                 250                 255     


Gly Gly Asp Asp Arg Ser Leu Ser Ser Ser Ser Ser Glu Ala Ser His 
            260                 265                 270         


Leu Asp Val Ser Ala Ser Ser Arg Leu Thr Ala Trp Pro Glu Gln Ser 
        275                 280                 285             


Ser Ser Ser Ala Ser Thr Ser Gln Glu Gly Pro Arg Pro Ala Ala Ala 
    290                 295                 300                 


Gln Ala Ala Gly Glu Ala Met Val Gly Ala Ser Arg Pro Pro Pro Lys 
305                 310                 315                 320 


Pro Leu Arg Pro Arg Gln Leu Gln Glu Val Gly Arg Gln Ser Ser Ser 
                325                 330                 335     


Asp Ser Gly Ile Ala Thr Gly Ser His Ser Ser Tyr Ser Ser Ser Leu 
            340                 345                 350         


Ser Ser Tyr Ala Gly Ser Ser Leu Asp Val Trp Arg Ala Thr Asp Glu 
        355                 360                 365             


Leu Gly Ser Leu Leu Ser Leu Pro Ala Ala Gly Ala Pro Glu Pro Ser 
    370                 375                 380                 


Leu Cys Thr Cys Leu Pro Gly Thr Val Glu Tyr Gln Val Pro Thr Ser 
385                 390                 395                 400 


Leu Arg Ala His Tyr Asp Thr Pro Arg Ser Leu Cys Leu Ala Pro Arg 
                405                 410                 415     


Asp His Ser Pro Pro Ser Gln Gly Ser Pro Gly Asn Ser Ala Ala Arg 
            420                 425                 430         


Asp Ser Gly Gly Gln Thr Ser Ala Gly Cys Pro Ser Gly Trp Leu Gly 
        435                 440                 445             


Thr Arg Arg Arg Gly Leu Val Met Glu Ala Pro Gln Gly Ser Glu Ala 
    450                 455                 460                 


Thr Leu Pro Gly Pro Ala Pro Gly Glu Pro Trp Glu Ala Gly Gly Pro 
465                 470                 475                 480 


His Ala Gly Pro Pro Pro Ala Phe Phe Ser Ala Cys Pro Val Cys Gly 
                485                 490                 495     


Gly Leu Lys Val Asn Pro Pro Pro 
            500                 


<210>  3
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Q8NFH5

<400>  3

Met Ala Ala Phe Ala Val Glu Pro Gln Gly Pro Ala Leu Gly Ser Glu 
1               5                   10                  15      


Pro Met Met Leu Gly Ser Pro Thr Ser Pro Lys Pro Gly Val Asn Ala 
            20                  25                  30          


Gln Phe Leu Pro Gly Phe Leu Met Gly Asp Leu Pro Ala Pro Val Thr 
        35                  40                  45              


Pro Gln Pro Arg Ser Ile Ser Gly Pro Ser Val Gly Val Met Glu Met 
    50                  55                  60                  


Arg Ser Pro Leu Leu Ala Gly Gly Ser Pro Pro Gln Pro Val Val Pro 
65                  70                  75                  80  


Ala His Lys Asp Lys Ser Gly Ala Pro Pro Val Arg Ser Ile Tyr Asp 
                85                  90                  95      


Asp Ile Ser Ser Pro Gly Leu Gly Ser Thr Pro Leu Thr Ser Arg Arg 
            100                 105                 110         


Gln Pro Asn Ile Ser Val Met Gln Ser Pro Leu Val Gly Val Thr Ser 
        115                 120                 125             


Thr Pro Gly Thr Gly Gln Ser Met Phe Ser Pro Ala Ser Ile Gly Gln 
    130                 135                 140                 


Pro Arg Lys Thr Thr Leu Ser Pro Ala Gln Leu Asp Pro Phe Tyr Thr 
145                 150                 155                 160 


Gln Gly Asp Ser Leu Thr Ser Glu Asp His Leu Asp Asp Ser Trp Val 
                165                 170                 175     


Thr Val Phe Gly Phe Pro Gln Ala Ser Ala Ser Tyr Ile Leu Leu Gln 
            180                 185                 190         


Phe Ala Gln Tyr Gly Asn Ile Leu Lys His Val Met Ser Asn Thr Gly 
        195                 200                 205             


Asn Trp Met His Ile Arg Tyr Gln Ser Lys Leu Gln Ala Arg Lys Ala 
    210                 215                 220                 


Leu Ser Lys Asp Gly Arg Ile Phe Gly Glu Ser Ile Met Ile Gly Val 
225                 230                 235                 240 


Lys Pro Cys Ile Asp Lys Ser Val Met Glu Ser Ser Asp Arg Cys Ala 
                245                 250                 255     


Leu Ser Ser Pro Ser Leu Ala Phe Thr Pro Pro Ile Lys Thr Leu Gly 
            260                 265                 270         


Thr Pro Thr Gln Pro Gly Ser Thr Pro Arg Ile Ser Thr Met Arg Pro 
        275                 280                 285             


Leu Ala Thr Ala Tyr Lys Ala Ser Thr Ser Asp Tyr Gln Val Ile Ser 
    290                 295                 300                 


Asp Arg Gln Thr Pro Lys Lys Asp Glu Ser Leu Val Ser Lys Ala Met 
305                 310                 315                 320 


Glu Tyr Met Phe Gly Trp 
                325     


<210>  4
<211>  1049
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8WYL5

<400>  4

Met Ala Leu Val Thr Leu Gln Arg Ser Pro Thr Pro Ser Ala Ala Ser 
1               5                   10                  15      


Ser Ser Ala Ser Asn Ser Glu Leu Glu Ala Gly Ser Glu Glu Asp Arg 
            20                  25                  30          


Lys Leu Asn Leu Ser Leu Ser Glu Ser Phe Phe Met Val Lys Gly Ala 
        35                  40                  45              


Ala Leu Phe Leu Gln Gln Gly Ser Ser Pro Gln Gly Gln Arg Ser Leu 
    50                  55                  60                  


Gln His Pro His Lys His Ala Gly Asp Leu Pro Gln His Leu Gln Val 
65                  70                  75                  80  


Met Ile Asn Leu Leu Arg Cys Glu Asp Arg Ile Lys Leu Ala Val Arg 
                85                  90                  95      


Leu Glu Ser Ala Trp Ala Asp Arg Val Arg Tyr Met Val Val Val Tyr 
            100                 105                 110         


Ser Ser Gly Arg Gln Asp Thr Glu Glu Asn Ile Leu Leu Gly Val Asp 
        115                 120                 125             


Phe Ser Ser Lys Glu Ser Lys Ser Cys Thr Ile Gly Met Val Leu Arg 
    130                 135                 140                 


Leu Trp Ser Asp Thr Lys Ile His Leu Asp Gly Asp Gly Gly Phe Ser 
145                 150                 155                 160 


Val Ser Thr Ala Gly Arg Met His Ile Phe Lys Pro Val Ser Val Gln 
                165                 170                 175     


Ala Met Trp Ser Ala Leu Gln Val Leu His Lys Ala Cys Glu Val Ala 
            180                 185                 190         


Arg Arg His Asn Tyr Phe Pro Gly Gly Val Ala Leu Ile Trp Ala Thr 
        195                 200                 205             


Tyr Tyr Glu Ser Cys Ile Ser Ser Glu Gln Ser Cys Ile Asn Glu Trp 
    210                 215                 220                 


Asn Ala Met Gln Asp Leu Glu Ser Thr Arg Pro Asp Ser Pro Ala Leu 
225                 230                 235                 240 


Phe Val Asp Lys Pro Thr Glu Gly Glu Arg Thr Glu Arg Leu Ile Lys 
                245                 250                 255     


Ala Lys Leu Arg Ser Ile Met Met Ser Gln Asp Leu Glu Asn Val Thr 
            260                 265                 270         


Ser Lys Glu Ile Arg Asn Glu Leu Glu Lys Gln Met Asn Cys Asn Leu 
        275                 280                 285             


Lys Glu Leu Lys Glu Phe Ile Asp Asn Glu Met Leu Leu Ile Leu Gly 
    290                 295                 300                 


Gln Met Asp Lys Pro Ser Leu Ile Phe Asp His Leu Tyr Leu Gly Ser 
305                 310                 315                 320 


Glu Trp Asn Ala Ser Asn Leu Glu Glu Leu Gln Gly Ser Gly Val Asp 
                325                 330                 335     


Tyr Ile Leu Asn Val Thr Arg Glu Ile Asp Asn Phe Phe Pro Gly Leu 
            340                 345                 350         


Phe Ala Tyr His Asn Ile Arg Val Tyr Asp Glu Glu Thr Thr Asp Leu 
        355                 360                 365             


Leu Ala His Trp Asn Glu Ala Tyr His Phe Ile Asn Lys Ala Lys Arg 
    370                 375                 380                 


Asn His Ser Lys Cys Leu Val His Cys Lys Met Gly Val Ser Arg Ser 
385                 390                 395                 400 


Ala Ser Thr Val Ile Ala Tyr Ala Met Lys Glu Phe Gly Trp Pro Leu 
                405                 410                 415     


Glu Lys Ala Tyr Asn Tyr Val Lys Gln Lys Arg Ser Ile Thr Arg Pro 
            420                 425                 430         


Asn Ala Gly Phe Met Arg Gln Leu Ser Glu Tyr Glu Gly Ile Leu Asp 
        435                 440                 445             


Ala Ser Lys Gln Arg His Asn Lys Leu Trp Arg Gln Gln Thr Asp Ser 
    450                 455                 460                 


Ser Leu Gln Gln Pro Val Asp Asp Pro Ala Gly Pro Gly Asp Phe Leu 
465                 470                 475                 480 


Pro Glu Thr Pro Asp Gly Thr Pro Glu Ser Gln Leu Pro Phe Leu Asp 
                485                 490                 495     


Asp Ala Ala Gln Pro Gly Leu Gly Pro Pro Leu Pro Cys Cys Phe Arg 
            500                 505                 510         


Arg Leu Ser Asp Pro Leu Leu Pro Ser Pro Glu Asp Glu Thr Gly Ser 
        515                 520                 525             


Leu Val His Leu Glu Asp Pro Glu Arg Glu Ala Leu Leu Glu Glu Ala 
    530                 535                 540                 


Ala Pro Pro Ala Glu Val His Arg Pro Ala Arg Gln Pro Gln Gln Gly 
545                 550                 555                 560 


Ser Gly Leu Cys Glu Lys Asp Val Lys Lys Lys Leu Glu Phe Gly Ser 
                565                 570                 575     


Pro Lys Gly Arg Ser Gly Ser Leu Leu Gln Val Glu Glu Thr Glu Arg 
            580                 585                 590         


Glu Glu Gly Leu Gly Ala Gly Arg Trp Gly Gln Leu Pro Thr Gln Leu 
        595                 600                 605             


Asp Gln Asn Leu Leu Asn Ser Glu Asn Leu Asn Asn Asn Ser Lys Arg 
    610                 615                 620                 


Ser Cys Pro Asn Gly Met Glu Asp Asp Ala Ile Phe Gly Ile Leu Asn 
625                 630                 635                 640 


Lys Val Lys Pro Ser Tyr Lys Ser Cys Ala Asp Cys Met Tyr Pro Thr 
                645                 650                 655     


Ala Ser Gly Ala Pro Glu Ala Ser Arg Glu Arg Cys Glu Asp Pro Asn 
            660                 665                 670         


Ala Pro Ala Ile Cys Thr Gln Pro Ala Phe Leu Pro His Ile Thr Ser 
        675                 680                 685             


Ser Pro Val Ala His Leu Ala Ser Arg Ser Arg Val Pro Glu Lys Pro 
    690                 695                 700                 


Ala Ser Gly Pro Thr Glu Pro Pro Pro Phe Leu Pro Pro Ala Gly Ser 
705                 710                 715                 720 


Arg Arg Ala Asp Thr Ser Gly Pro Gly Ala Gly Ala Ala Leu Glu Pro 
                725                 730                 735     


Pro Ala Ser Leu Leu Glu Pro Ser Arg Glu Thr Pro Lys Val Leu Pro 
            740                 745                 750         


Lys Ser Leu Leu Leu Lys Asn Ser His Cys Asp Lys Asn Pro Pro Ser 
        755                 760                 765             


Thr Glu Val Val Ile Lys Glu Glu Ser Ser Pro Lys Lys Asp Met Lys 
    770                 775                 780                 


Pro Ala Lys Asp Leu Arg Leu Leu Phe Ser Asn Glu Ser Glu Lys Pro 
785                 790                 795                 800 


Thr Thr Asn Ser Tyr Leu Met Gln His Gln Glu Ser Ile Ile Gln Leu 
                805                 810                 815     


Gln Lys Ala Gly Leu Val Arg Lys His Thr Lys Glu Leu Glu Arg Leu 
            820                 825                 830         


Lys Ser Val Pro Ala Asp Pro Ala Pro Pro Ser Arg Asp Gly Pro Ala 
        835                 840                 845             


Ser Arg Leu Glu Ala Ser Ile Pro Glu Glu Ser Gln Asp Pro Ala Ala 
    850                 855                 860                 


Leu His Glu Leu Gly Pro Leu Val Met Pro Ser Gln Ala Gly Ser Asp 
865                 870                 875                 880 


Glu Lys Ser Glu Ala Ala Pro Ala Ser Leu Glu Gly Gly Ser Leu Lys 
                885                 890                 895     


Ser Pro Pro Pro Phe Phe Tyr Arg Leu Asp His Thr Ser Ser Phe Ser 
            900                 905                 910         


Lys Asp Phe Leu Lys Thr Ile Cys Tyr Thr Pro Thr Ser Ser Ser Met 
        915                 920                 925             


Ser Ser Asn Leu Thr Arg Ser Ser Ser Ser Asp Ser Ile His Ser Val 
    930                 935                 940                 


Arg Gly Lys Pro Gly Leu Val Lys Gln Arg Thr Gln Glu Ile Glu Thr 
945                 950                 955                 960 


Arg Leu Arg Leu Ala Gly Leu Thr Val Ser Ser Pro Leu Lys Arg Ser 
                965                 970                 975     


His Ser Leu Ala Lys Leu Gly Ser Leu Thr Phe Ser Thr Glu Asp Leu 
            980                 985                 990         


Ser Ser Glu Ala Asp Pro Ser Thr  Val Ala Asp Ser Gln  Asp Thr Thr 
        995                 1000                 1005             


Leu Ser  Glu Ser Ser Phe Leu  His Glu Pro Gln Gly  Thr Pro Arg 
    1010                 1015                 1020             


Asp Pro  Ala Ala Thr Ser Lys  Pro Ser Gly Lys Pro  Ala Pro Glu 
    1025                 1030                 1035             


Asn Leu  Lys Ser Pro Ser Trp  Met Ser Lys Ser 
    1040                 1045                 


<210>  5
<211>  2048
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8IYD8

<400>  5

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  6
<211>  1257
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  O14654

<400>  6

Met Ala Ser Cys Ser Phe Thr Arg Asp Gln Ala Thr Arg Arg Leu Arg 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Ala Ala Ala Leu Ala Ala Val Val Thr Thr 
            20                  25                  30          


Pro Leu Leu Ser Ser Gly Thr Pro Thr Ala Leu Ile Gly Thr Gly Ser 
        35                  40                  45              


Ser Cys Pro Gly Ala Met Trp Leu Ser Thr Ala Thr Gly Ser Arg Ser 
    50                  55                  60                  


Asp Ser Glu Ser Glu Glu Glu Asp Leu Pro Val Gly Glu Glu Val Cys 
65                  70                  75                  80  


Lys Arg Gly Tyr Leu Arg Lys Gln Lys His Gly His Arg Arg Tyr Phe 
                85                  90                  95      


Val Leu Lys Leu Glu Thr Ala Asp Ala Pro Ala Arg Leu Glu Tyr Tyr 
            100                 105                 110         


Glu Asn Ala Arg Lys Phe Arg His Ser Val Arg Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ser Gly Ala Ala Ile Pro Pro Leu Ile Pro Pro 
    130                 135                 140                 


Arg Arg Val Ile Thr Leu Tyr Gln Cys Phe Ser Val Ser Gln Arg Ala 
145                 150                 155                 160 


Asp Ala Arg Tyr Arg His Leu Ile Ala Leu Phe Thr Gln Asp Glu Tyr 
                165                 170                 175     


Phe Ala Met Val Ala Glu Asn Glu Ser Glu Gln Glu Ser Trp Tyr Leu 
            180                 185                 190         


Leu Leu Ser Arg Leu Ile Leu Glu Ser Lys Arg Arg Arg Cys Gly Thr 
        195                 200                 205             


Leu Gly Ala Gln Pro Asp Gly Glu Pro Ala Ala Leu Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Glu Pro Pro Phe Tyr Lys Asp Val Trp Gln Val Ile Val Lys 
225                 230                 235                 240 


Pro Arg Gly Leu Gly His Arg Lys Glu Leu Ser Gly Val Phe Arg Leu 
                245                 250                 255     


Cys Leu Thr Asp Glu Glu Val Val Phe Val Arg Leu Asn Thr Glu Val 
            260                 265                 270         


Ala Ser Val Val Val Gln Leu Leu Ser Ile Arg Arg Cys Gly His Ser 
        275                 280                 285             


Glu Gln Tyr Phe Phe Leu Glu Val Gly Arg Ser Thr Val Ile Gly Pro 
    290                 295                 300                 


Gly Glu Leu Trp Met Gln Val Asp Asp Cys Val Val Ala Gln Asn Met 
305                 310                 315                 320 


His Glu Leu Phe Leu Glu Lys Met Arg Ala Leu Cys Ala Asp Glu Tyr 
                325                 330                 335     


Arg Ala Arg Cys Arg Ser Tyr Ser Ile Ser Ile Gly Ala His Leu Leu 
            340                 345                 350         


Thr Leu Leu Ser Ala Arg Arg His Leu Gly Leu Val Pro Leu Glu Pro 
        355                 360                 365             


Gly Gly Trp Leu Arg Arg Ser Arg Phe Glu Gln Phe Cys His Leu Arg 
    370                 375                 380                 


Ala Ile Gly Asp Gly Glu Asp Glu Met Leu Phe Thr Arg Arg Phe Val 
385                 390                 395                 400 


Thr Pro Ser Glu Pro Val Ala His Ser Arg Arg Gly Arg Leu His Leu 
                405                 410                 415     


Pro Arg Gly Arg Arg Ser Arg Arg Ala Val Ser Val Pro Ala Ser Phe 
            420                 425                 430         


Phe Arg Arg Leu Ala Pro Ser Pro Ala Arg Pro Arg His Pro Ala Glu 
        435                 440                 445             


Ala Pro Asn Asn Gly Ala Arg Leu Ser Ser Glu Val Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Asn Phe Gly Glu Glu Gly Asn Pro Gln Gly Lys Glu Asp Gln 
465                 470                 475                 480 


Glu Gly Ser Gly Gly Asp Tyr Met Pro Met Asn Asn Trp Gly Ser Gly 
                485                 490                 495     


Asn Gly Arg Gly Ser Gly Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser 
            500                 505                 510         


Ser Ser His Ser Ser Gly Gly Asn Gln Cys Ser Gly Glu Gly Gln Gly 
        515                 520                 525             


Ser Arg Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser Gly Gly Asn Gln 
    530                 535                 540                 


Cys Ser Arg Asp Gly Gln Gly Thr Ala Gly Gly His Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Arg Pro Gly Gly Gly His Gly Ser Gly Gly Gly Gln Gly Pro 
                565                 570                 575     


Gly Asp Gly His Gly Ser Gly Gly Gly Lys Asn Ser Gly Gly Gly Lys 
            580                 585                 590         


Gly Ser Gly Ser Gly Lys Gly Ser Asp Gly Asp Gly Glu Arg Gly Lys 
        595                 600                 605             


Ser Leu Lys Lys Arg Ser Tyr Phe Gly Lys Leu Thr Gln Ser Lys Gln 
    610                 615                 620                 


Gln Gln Met Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala 
625                 630                 635                 640 


Gly Gly Thr Gly Gly Lys Gly Lys Ser Gly Gly Arg Phe Arg Leu Tyr 
                645                 650                 655     


Phe Cys Val Asp Arg Gly Ala Thr Lys Glu Cys Lys Glu Ala Lys Glu 
            660                 665                 670         


Val Lys Asp Ala Glu Ile Pro Glu Gly Ala Ala Arg Gly Pro His Arg 
        675                 680                 685             


Ala Arg Ala Phe Asp Glu Asp Glu Asp Asp Pro Tyr Val Pro Met Arg 
    690                 695                 700                 


Pro Gly Val Ala Thr Pro Leu Val Ser Ser Ser Asp Tyr Met Pro Met 
705                 710                 715                 720 


Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg His Ser Arg Ser Pro 
                725                 730                 735     


Phe Glu Asp Ser Arg Gly Tyr Met Met Met Phe Pro Arg Val Ser Pro 
            740                 745                 750         


Pro Pro Ala Pro Ser Pro Pro Lys Ala Pro Asp Thr Asn Lys Glu Asp 
        755                 760                 765             


Asp Ser Lys Asp Asn Asp Ser Glu Ser Asp Tyr Met Phe Met Ala Pro 
    770                 775                 780                 


Gly Ala Gly Ala Ile Pro Lys Asn Pro Arg Asn Pro Gln Gly Gly Ser 
785                 790                 795                 800 


Ser Ser Lys Ser Trp Ser Ser Tyr Phe Ser Leu Pro Asn Pro Phe Arg 
                805                 810                 815     


Ser Ser Pro Leu Gly Gln Asn Asp Asn Ser Glu Tyr Val Pro Met Leu 
            820                 825                 830         


Pro Gly Lys Phe Leu Gly Arg Gly Leu Asp Lys Glu Val Ser Tyr Asn 
        835                 840                 845             


Trp Asp Pro Lys Asp Ala Ala Ser Lys Pro Ser Gly Glu Gly Ser Phe 
    850                 855                 860                 


Ser Lys Pro Gly Asp Gly Gly Ser Pro Ser Lys Pro Ser Asp His Glu 
865                 870                 875                 880 


Pro Pro Lys Asn Lys Ala Lys Arg Pro Asn Arg Leu Ser Phe Ile Thr 
                885                 890                 895     


Lys Gly Tyr Lys Ile Lys Pro Lys Pro Gln Lys Pro Thr His Glu Gln 
            900                 905                 910         


Arg Glu Ala Asp Ser Ser Ser Asp Tyr Val Asn Met Asp Phe Thr Lys 
        915                 920                 925             


Arg Glu Ser Asn Thr Pro Ala Pro Ser Thr Gln Gly Leu Pro Asp Ser 
    930                 935                 940                 


Trp Gly Ile Ile Ala Glu Pro Arg Gln Ser Ala Phe Ser Asn Tyr Val 
945                 950                 955                 960 


Asn Val Glu Phe Gly Val Pro Phe Pro Asn Pro Ala Asn Asp Leu Ser 
                965                 970                 975     


Asp Leu Leu Arg Ala Ile Pro Arg Ala Asn Pro Leu Ser Leu Asp Ser 
            980                 985                 990         


Ala Arg Trp Pro Leu Pro Pro Leu  Pro Leu Ser Ala Thr  Gly Ser Asn 
        995                 1000                 1005             


Ala Ile  Glu Glu Glu Gly Asp  Tyr Ile Glu Val Ile  Phe Asn Ser 
    1010                 1015                 1020             


Ala Met  Thr Pro Ala Met Ala  Leu Ala Asp Ser Ala  Ile Arg Tyr 
    1025                 1030                 1035             


Asp Ala  Glu Thr Gly Arg Ile  Tyr Val Val Asp Pro  Phe Ser Glu 
    1040                 1045                 1050             


Cys Cys  Met Asp Ile Ser Leu  Ser Pro Ser Arg Cys  Ser Glu Pro 
    1055                 1060                 1065             


Pro Pro  Val Ala Arg Leu Leu  Gln Glu Glu Glu Gln  Glu Arg Arg 
    1070                 1075                 1080             


Arg Pro  Gln Ser Arg Ser Gln  Ser Phe Phe Ala Ala  Ala Arg Ala 
    1085                 1090                 1095             


Ala Val  Ser Ala Phe Pro Thr  Asp Ser Leu Glu Arg  Asp Leu Ser 
    1100                 1105                 1110             


Pro Ser  Ser Ala Pro Ala Val  Ala Ser Ala Ala Glu  Pro Thr Leu 
    1115                 1120                 1125             


Ala Leu  Ser Gln Val Val Ala  Ala Ala Ser Ala Leu  Ala Ala Ala 
    1130                 1135                 1140             


Pro Gly  Ile Gly Ala Ala Ala  Ala Ala Ala Gly Phe  Asp Ser Ala 
    1145                 1150                 1155             


Ser Ala  Arg Trp Phe Gln Pro  Val Ala Asn Ala Ala  Asp Ala Glu 
    1160                 1165                 1170             


Ala Val  Arg Gly Ala Gln Asp  Val Ala Gly Gly Ser  Asn Pro Gly 
    1175                 1180                 1185             


Ala His  Asn Pro Ser Ala Asn  Leu Ala Arg Gly Asp  Asn Gln Ala 
    1190                 1195                 1200             


Gly Gly  Ala Ala Ala Ala Ala  Ala Ala Pro Glu Pro  Pro Pro Arg 
    1205                 1210                 1215             


Ser Arg  Arg Val Pro Arg Pro  Pro Glu Arg Glu Asp  Ser Asp Asn 
    1220                 1225                 1230             


Asp Asp  Asp Thr His Val Arg  Met Asp Phe Ala Arg  Arg Asp Asn 
    1235                 1240                 1245             


Gln Phe  Asp Ser Pro Lys Arg  Gly Arg 
    1250                 1255         


<210>  7
<211>  578
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q96AP4

<400>  7

Met Leu Ser Cys Asn Ile Cys Gly Glu Thr Val Thr Ser Glu Pro Asp 
1               5                   10                  15      


Met Lys Ala His Leu Ile Val His Met Glu Ser Glu Ile Ile Cys Pro 
            20                  25                  30          


Phe Cys Lys Leu Ser Gly Val Asn Tyr Asp Glu Met Cys Phe His Ile 
        35                  40                  45              


Glu Thr Ala His Phe Glu Gln Asn Thr Leu Glu Arg Asn Phe Glu Arg 
    50                  55                  60                  


Ile Asn Thr Val Gln Tyr Gly Thr Ser Asp Asn Lys Lys Asp Asn Thr 
65                  70                  75                  80  


Leu Gln Cys Gly Met Glu Val Asn Ser Ser Ile Leu Ser Gly Cys Ala 
                85                  90                  95      


Ser Asn His Pro Lys Asn Ser Ala Gln Asn Leu Thr Lys Asp Ser Thr 
            100                 105                 110         


Leu Lys His Glu Gly Phe Tyr Ser Glu Asn Leu Thr Glu Ser Arg Lys 
        115                 120                 125             


Phe Leu Lys Ser Arg Glu Lys Gln Ser Ser Leu Thr Glu Ile Lys Gly 
    130                 135                 140                 


Ser Val Tyr Glu Thr Thr Tyr Ser Pro Pro Glu Cys Pro Phe Cys Gly 
145                 150                 155                 160 


Lys Ile Glu Glu His Ser Glu Asp Met Glu Thr His Val Lys Thr Lys 
                165                 170                 175     


His Ala Asn Leu Leu Asp Ile Pro Leu Glu Asp Cys Asp Gln Pro Leu 
            180                 185                 190         


Tyr Asp Cys Pro Met Cys Gly Leu Ile Cys Thr Asn Tyr His Ile Leu 
        195                 200                 205             


Gln Glu His Val Asp Leu His Leu Glu Glu Asn Ser Phe Gln Gln Gly 
    210                 215                 220                 


Met Asp Arg Val Gln Cys Ser Gly Asp Leu Gln Leu Ala His Gln Leu 
225                 230                 235                 240 


Gln Gln Glu Glu Asp Arg Lys Arg Arg Ser Glu Glu Ser Arg Gln Glu 
                245                 250                 255     


Ile Glu Glu Phe Gln Lys Leu Gln Arg Gln Tyr Gly Leu Asp Asn Ser 
            260                 265                 270         


Gly Gly Tyr Lys Gln Gln Gln Leu Arg Asn Met Glu Ile Glu Val Asn 
        275                 280                 285             


Arg Gly Arg Met Pro Pro Ser Glu Phe His Arg Arg Lys Ala Asp Met 
    290                 295                 300                 


Met Glu Ser Leu Ala Leu Gly Phe Asp Asp Gly Lys Thr Lys Thr Ser 
305                 310                 315                 320 


Gly Ile Ile Glu Ala Leu His Arg Tyr Tyr Gln Asn Ala Ala Thr Asp 
                325                 330                 335     


Val Arg Arg Val Trp Leu Ser Ser Val Val Asp His Phe His Ser Ser 
            340                 345                 350         


Leu Gly Asp Lys Gly Trp Gly Cys Gly Tyr Arg Asn Phe Gln Met Leu 
        355                 360                 365             


Leu Ser Ser Leu Leu Gln Asn Asp Ala Tyr Asn Asp Cys Leu Lys Gly 
    370                 375                 380                 


Met Leu Ile Pro Cys Ile Pro Lys Ile Gln Ser Met Ile Glu Asp Ala 
385                 390                 395                 400 


Trp Lys Glu Gly Phe Asp Pro Gln Gly Ala Ser Gln Leu Asn Asn Arg 
                405                 410                 415     


Leu Gln Gly Thr Lys Ala Trp Ile Gly Ala Cys Glu Val Tyr Ile Leu 
            420                 425                 430         


Leu Thr Ser Leu Arg Val Lys Cys His Ile Val Asp Phe His Lys Ser 
        435                 440                 445             


Thr Gly Pro Leu Gly Thr His Pro Arg Leu Phe Glu Trp Ile Leu Asn 
    450                 455                 460                 


Tyr Tyr Ser Ser Glu Gly Glu Gly Ser Pro Lys Val Val Cys Thr Ser 
465                 470                 475                 480 


Lys Pro Pro Ile Tyr Leu Gln His Gln Gly His Ser Arg Thr Val Ile 
                485                 490                 495     


Gly Ile Glu Glu Lys Lys Asn Arg Thr Leu Cys Leu Leu Ile Leu Asp 
            500                 505                 510         


Pro Gly Cys Pro Ser Arg Glu Met Gln Lys Leu Leu Lys Gln Asp Ile 
        515                 520                 525             


Glu Ala Ser Ser Leu Lys Gln Leu Arg Lys Ser Met Gly Asn Leu Lys 
    530                 535                 540                 


His Lys Gln Tyr Gln Ile Leu Ala Val Glu Gly Ala Leu Ser Leu Glu 
545                 550                 555                 560 


Glu Lys Leu Ala Arg Arg Gln Ala Ser Gln Val Phe Thr Ala Glu Lys 
                565                 570                 575     


Ile Pro 
        


<210>  8
<211>  2752
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9UQ35

<400>  8

Met Tyr Asn Gly Ile Gly Leu Pro Thr Pro Arg Gly Ser Gly Thr Asn 
1               5                   10                  15      


Gly Tyr Val Gln Arg Asn Leu Ser Leu Val Arg Gly Arg Arg Gly Glu 
            20                  25                  30          


Arg Pro Asp Tyr Lys Gly Glu Glu Glu Leu Arg Arg Leu Glu Ala Ala 
        35                  40                  45              


Leu Val Lys Arg Pro Asn Pro Asp Ile Leu Asp His Glu Arg Lys Arg 
    50                  55                  60                  


Arg Val Glu Leu Arg Cys Leu Glu Leu Glu Glu Met Met Glu Glu Gln 
65                  70                  75                  80  


Gly Tyr Glu Glu Gln Gln Ile Gln Glu Lys Val Ala Thr Phe Arg Leu 
                85                  90                  95      


Met Leu Leu Glu Lys Asp Val Asn Pro Gly Gly Lys Glu Glu Thr Pro 
            100                 105                 110         


Gly Gln Arg Pro Ala Val Thr Glu Thr His Gln Leu Ala Glu Leu Asn 
        115                 120                 125             


Glu Lys Lys Asn Glu Arg Leu Arg Ala Ala Phe Gly Ile Ser Asp Ser 
    130                 135                 140                 


Tyr Val Asp Gly Ser Ser Phe Asp Pro Gln Arg Arg Ala Arg Glu Ala 
145                 150                 155                 160 


Lys Gln Pro Ala Pro Glu Pro Pro Lys Pro Tyr Ser Leu Val Arg Glu 
                165                 170                 175     


Ser Ser Ser Ser Arg Ser Pro Thr Pro Lys Gln Lys Lys Lys Lys Lys 
            180                 185                 190         


Lys Lys Asp Arg Gly Arg Arg Ser Glu Ser Ser Ser Pro Arg Arg Glu 
        195                 200                 205             


Arg Lys Lys Ser Ser Lys Lys Lys Lys His Arg Ser Glu Ser Glu Ser 
    210                 215                 220                 


Lys Lys Arg Lys His Arg Ser Pro Thr Pro Lys Ser Lys Arg Lys Ser 
225                 230                 235                 240 


Lys Asp Lys Lys Arg Lys Arg Ser Arg Ser Thr Thr Pro Ala Pro Lys 
                245                 250                 255     


Ser Arg Arg Ala His Arg Ser Thr Ser Ala Asp Ser Ala Ser Ser Ser 
            260                 265                 270         


Asp Thr Ser Arg Ser Arg Ser Arg Ser Ala Ala Ala Lys Thr His Thr 
        275                 280                 285             


Thr Ala Leu Ala Gly Arg Ser Pro Ser Pro Ala Ser Gly Arg Arg Gly 
    290                 295                 300                 


Glu Gly Asp Ala Pro Phe Ser Glu Pro Gly Thr Thr Ser Thr Gln Arg 
305                 310                 315                 320 


Pro Ser Ser Pro Glu Thr Ala Thr Lys Gln Pro Ser Ser Pro Tyr Glu 
                325                 330                 335     


Asp Lys Asp Lys Asp Lys Lys Glu Lys Ser Ala Thr Arg Pro Ser Pro 
            340                 345                 350         


Ser Pro Glu Arg Ser Ser Thr Gly Pro Glu Pro Pro Ala Pro Thr Pro 
        355                 360                 365             


Leu Leu Ala Glu Arg His Gly Gly Ser Pro Gln Pro Leu Ala Thr Thr 
    370                 375                 380                 


Pro Leu Ser Gln Glu Pro Val Asn Pro Pro Ser Glu Ala Ser Pro Thr 
385                 390                 395                 400 


Arg Asp Arg Ser Pro Pro Lys Ser Pro Glu Lys Leu Pro Gln Ser Ser 
                405                 410                 415     


Ser Ser Glu Ser Ser Pro Pro Ser Pro Gln Pro Thr Lys Val Ser Arg 
            420                 425                 430         


His Ala Ser Ser Ser Pro Glu Ser Pro Lys Pro Ala Pro Ala Pro Gly 
        435                 440                 445             


Ser His Arg Glu Ile Ser Ser Ser Pro Thr Ser Lys Asn Arg Ser His 
    450                 455                 460                 


Gly Arg Ala Lys Arg Asp Lys Ser His Ser His Thr Pro Ser Arg Arg 
465                 470                 475                 480 


Met Gly Arg Ser Arg Ser Pro Ala Thr Ala Lys Arg Gly Arg Ser Arg 
                485                 490                 495     


Ser Arg Thr Pro Thr Lys Arg Gly His Ser Arg Ser Arg Ser Pro Gln 
            500                 505                 510         


Trp Arg Arg Ser Arg Ser Ala Gln Arg Trp Gly Arg Ser Arg Ser Pro 
        515                 520                 525             


Gln Arg Arg Gly Arg Ser Arg Ser Pro Gln Arg Pro Gly Trp Ser Arg 
    530                 535                 540                 


Ser Arg Asn Thr Gln Arg Arg Gly Arg Ser Arg Ser Ala Arg Arg Gly 
545                 550                 555                 560 


Arg Ser His Ser Arg Ser Pro Ala Thr Arg Gly Arg Ser Arg Ser Arg 
                565                 570                 575     


Thr Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg 
            580                 585                 590         


Arg Ser Arg Ser Arg Thr Pro Thr Arg Arg Arg Ser Arg Ser Arg Thr 
        595                 600                 605             


Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Arg 
    610                 615                 620                 


Ser Arg Thr Arg Ser Pro Val Arg Arg Arg Ser Arg Ser Arg Ser Pro 
625                 630                 635                 640 


Ala Arg Arg Ser Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Gly 
                645                 650                 655     


Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg 
            660                 665                 670         


Thr Pro Ala Arg Arg Ser Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg 
        675                 680                 685             


Arg Gly Arg Ser Arg Ser Arg Thr Pro Arg Arg Gly Arg Ser Arg Ser 
    690                 695                 700                 


Arg Ser Leu Val Arg Arg Gly Arg Ser His Ser Arg Thr Pro Gln Arg 
705                 710                 715                 720 


Arg Gly Arg Ser Gly Ser Ser Ser Glu Arg Lys Asn Lys Ser Arg Thr 
                725                 730                 735     


Ser Gln Arg Arg Ser Arg Ser Asn Ser Ser Pro Glu Met Lys Lys Ser 
            740                 745                 750         


Arg Ile Ser Ser Arg Arg Ser Arg Ser Leu Ser Ser Pro Arg Ser Lys 
        755                 760                 765             


Ala Lys Ser Arg Leu Ser Leu Arg Arg Ser Leu Ser Gly Ser Ser Pro 
    770                 775                 780                 


Cys Pro Lys Gln Lys Ser Gln Thr Pro Pro Arg Arg Ser Arg Ser Gly 
785                 790                 795                 800 


Ser Ser Gln Pro Lys Ala Lys Ser Arg Thr Pro Pro Arg Arg Ser Arg 
                805                 810                 815     


Ser Ser Ser Ser Pro Pro Pro Lys Gln Lys Ser Lys Thr Pro Ser Arg 
            820                 825                 830         


Gln Ser His Ser Ser Ser Ser Pro His Pro Lys Val Lys Ser Gly Thr 
        835                 840                 845             


Pro Pro Arg Gln Gly Ser Ile Thr Ser Pro Gln Ala Asn Glu Gln Ser 
    850                 855                 860                 


Val Thr Pro Gln Arg Arg Ser Cys Phe Glu Ser Ser Pro Asp Pro Glu 
865                 870                 875                 880 


Leu Lys Ser Arg Thr Pro Ser Arg His Ser Cys Ser Gly Ser Ser Pro 
                885                 890                 895     


Pro Arg Val Lys Ser Ser Thr Pro Pro Arg Gln Ser Pro Ser Arg Ser 
            900                 905                 910         


Ser Ser Pro Gln Pro Lys Val Lys Ala Ile Ile Ser Pro Arg Gln Arg 
        915                 920                 925             


Ser His Ser Gly Ser Ser Ser Pro Ser Pro Ser Arg Val Thr Ser Arg 
    930                 935                 940                 


Thr Thr Pro Arg Arg Ser Arg Ser Val Ser Pro Cys Ser Asn Val Glu 
945                 950                 955                 960 


Ser Arg Leu Leu Pro Arg Tyr Ser His Ser Gly Ser Ser Ser Pro Asp 
                965                 970                 975     


Thr Lys Val Lys Pro Glu Thr Pro Pro Arg Gln Ser His Ser Gly Ser 
            980                 985                 990         


Ile Ser Pro Tyr Pro Lys Val Lys  Ala Gln Thr Pro Pro  Gly Pro Ser 
        995                 1000                 1005             


Leu Ser  Gly Ser Lys Ser Pro  Cys Pro Gln Glu Lys  Ser Lys Asp 
    1010                 1015                 1020             


Ser Leu  Val Gln Ser Cys Pro  Gly Ser Leu Ser Leu  Cys Ala Gly 
    1025                 1030                 1035             


Val Lys  Ser Ser Thr Pro Pro  Gly Glu Ser Tyr Phe  Gly Val Ser 
    1040                 1045                 1050             


Ser Leu  Gln Leu Lys Gly Gln  Ser Gln Thr Ser Pro  Asp His Arg 
    1055                 1060                 1065             


Ser Asp  Thr Ser Ser Pro Glu  Val Arg Gln Ser His  Ser Glu Ser 
    1070                 1075                 1080             


Pro Ser  Leu Gln Ser Lys Ser  Gln Thr Ser Pro Lys  Gly Gly Arg 
    1085                 1090                 1095             


Ser Arg  Ser Ser Ser Pro Val  Thr Glu Leu Ala Ser  Arg Ser Pro 
    1100                 1105                 1110             


Ile Arg  Gln Asp Arg Gly Glu  Phe Ser Ala Ser Pro  Met Leu Lys 
    1115                 1120                 1125             


Ser Gly  Met Ser Pro Glu Gln  Ser Arg Phe Gln Ser  Asp Ser Ser 
    1130                 1135                 1140             


Ser Tyr  Pro Thr Val Asp Ser  Asn Ser Leu Leu Gly  Gln Ser Arg 
    1145                 1150                 1155             


Leu Glu  Thr Ala Glu Ser Lys  Glu Lys Met Ala Leu  Pro Pro Gln 
    1160                 1165                 1170             


Glu Asp  Ala Thr Ala Ser Pro  Pro Arg Gln Lys Asp  Lys Phe Ser 
    1175                 1180                 1185             


Pro Phe  Pro Val Gln Asp Arg  Pro Glu Ser Ser Leu  Val Phe Lys 
    1190                 1195                 1200             


Asp Thr  Leu Arg Thr Pro Pro  Arg Glu Arg Ser Gly  Ala Gly Ser 
    1205                 1210                 1215             


Ser Pro  Glu Thr Lys Glu Gln  Asn Ser Ala Leu Pro  Thr Ser Ser 
    1220                 1225                 1230             


Gln Asp  Glu Glu Leu Met Glu  Val Val Glu Lys Ser  Glu Glu Pro 
    1235                 1240                 1245             


Ala Gly  Gln Ile Leu Ser His  Leu Ser Ser Glu Leu  Lys Glu Met 
    1250                 1255                 1260             


Ser Thr  Ser Asn Phe Glu Ser  Ser Pro Glu Val Glu  Glu Arg Pro 
    1265                 1270                 1275             


Ala Val  Ser Leu Thr Leu Asp  Gln Ser Gln Ser Gln  Ala Ser Leu 
    1280                 1285                 1290             


Glu Ala  Val Glu Val Pro Ser  Met Ala Ser Ser Trp  Gly Gly Pro 
    1295                 1300                 1305             


His Phe  Ser Pro Glu His Lys  Glu Leu Ser Asn Ser  Pro Leu Arg 
    1310                 1315                 1320             


Glu Asn  Ser Phe Gly Ser Pro  Leu Glu Phe Arg Asn  Ser Gly Pro 
    1325                 1330                 1335             


Leu Gly  Thr Glu Met Asn Thr  Gly Phe Ser Ser Glu  Val Lys Glu 
    1340                 1345                 1350             


Asp Leu  Asn Gly Pro Phe Leu  Asn Gln Leu Glu Thr  Asp Pro Ser 
    1355                 1360                 1365             


Leu Asp  Met Lys Glu Gln Ser  Thr Arg Ser Ser Gly  His Ser Ser 
    1370                 1375                 1380             


Ser Glu  Leu Ser Pro Asp Ala  Val Glu Lys Ala Gly  Met Ser Ser 
    1385                 1390                 1395             


Asn Gln  Ser Ile Ser Ser Pro  Val Leu Asp Ala Val  Pro Arg Thr 
    1400                 1405                 1410             


Pro Ser  Arg Glu Arg Ser Ser  Ser Ala Ser Ser Pro  Glu Met Lys 
    1415                 1420                 1425             


Asp Gly  Leu Pro Arg Thr Pro  Ser Arg Arg Ser Arg  Ser Gly Ser 
    1430                 1435                 1440             


Ser Pro  Gly Leu Arg Asp Gly  Ser Gly Thr Pro Ser  Arg His Ser 
    1445                 1450                 1455             


Leu Ser  Gly Ser Ser Pro Gly  Met Lys Asp Ile Pro  Arg Thr Pro 
    1460                 1465                 1470             


Ser Arg  Gly Arg Ser Glu Cys  Asp Ser Ser Pro Glu  Pro Lys Ala 
    1475                 1480                 1485             


Leu Pro  Gln Thr Pro Arg Pro  Arg Ser Arg Ser Pro  Ser Ser Pro 
    1490                 1495                 1500             


Glu Leu  Asn Asn Lys Cys Leu  Thr Pro Gln Arg Glu  Arg Ser Gly 
    1505                 1510                 1515             


Ser Glu  Ser Ser Val Asp Gln  Lys Thr Val Ala Arg  Thr Pro Leu 
    1520                 1525                 1530             


Gly Gln  Arg Ser Arg Ser Gly  Ser Ser Gln Glu Leu  Asp Val Lys 
    1535                 1540                 1545             


Pro Ser  Ala Ser Pro Gln Glu  Arg Ser Glu Ser Asp  Ser Ser Pro 
    1550                 1555                 1560             


Asp Ser  Lys Ala Lys Thr Arg  Thr Pro Leu Arg Gln  Arg Ser Arg 
    1565                 1570                 1575             


Ser Gly  Ser Ser Pro Glu Val  Asp Ser Lys Ser Arg  Leu Ser Pro 
    1580                 1585                 1590             


Arg Arg  Ser Arg Ser Gly Ser  Ser Pro Glu Val Lys  Asp Lys Pro 
    1595                 1600                 1605             


Arg Ala  Ala Pro Arg Ala Gln  Ser Gly Ser Asp Ser  Ser Pro Glu 
    1610                 1615                 1620             


Pro Lys  Ala Pro Ala Pro Arg  Ala Leu Pro Arg Arg  Ser Arg Ser 
    1625                 1630                 1635             


Gly Ser  Ser Ser Lys Gly Arg  Gly Pro Ser Pro Glu  Gly Ser Ser 
    1640                 1645                 1650             


Ser Thr  Glu Ser Ser Pro Glu  His Pro Pro Lys Ser  Arg Thr Ala 
    1655                 1660                 1665             


Arg Arg  Gly Ser Arg Ser Ser  Pro Glu Pro Lys Thr  Lys Ser Arg 
    1670                 1675                 1680             


Thr Pro  Pro Arg Arg Arg Ser  Ser Arg Ser Ser Pro  Glu Leu Thr 
    1685                 1690                 1695             


Arg Lys  Ala Arg Leu Ser Arg  Arg Ser Arg Ser Ala  Ser Ser Ser 
    1700                 1705                 1710             


Pro Glu  Thr Arg Ser Arg Thr  Pro Pro Arg His Arg  Arg Ser Pro 
    1715                 1720                 1725             


Ser Val  Ser Ser Pro Glu Pro  Ala Glu Lys Ser Arg  Ser Ser Arg 
    1730                 1735                 1740             


Arg Arg  Arg Ser Ala Ser Ser  Pro Arg Thr Lys Thr  Thr Ser Arg 
    1745                 1750                 1755             


Arg Gly  Arg Ser Pro Ser Pro  Lys Pro Arg Gly Leu  Gln Arg Ser 
    1760                 1765                 1770             


Arg Ser  Arg Ser Arg Arg Glu  Lys Thr Arg Thr Thr  Arg Arg Arg 
    1775                 1780                 1785             


Asp Arg  Ser Gly Ser Ser Gln  Ser Thr Ser Arg Arg  Arg Gln Arg 
    1790                 1795                 1800             


Ser Arg  Ser Arg Ser Arg Val  Thr Arg Arg Arg Arg  Gly Gly Ser 
    1805                 1810                 1815             


Gly Tyr  His Ser Arg Ser Pro  Ala Arg Gln Glu Ser  Ser Arg Thr 
    1820                 1825                 1830             


Ser Ser  Arg Arg Arg Arg Gly  Arg Ser Arg Thr Pro  Pro Thr Ser 
    1835                 1840                 1845             


Arg Lys  Arg Ser Arg Ser Arg  Thr Ser Pro Ala Pro  Trp Lys Arg 
    1850                 1855                 1860             


Ser Arg  Ser Arg Ala Ser Pro  Ala Thr His Arg Arg  Ser Arg Ser 
    1865                 1870                 1875             


Arg Thr  Pro Leu Ile Ser Arg  Arg Arg Ser Arg Ser  Arg Thr Ser 
    1880                 1885                 1890             


Pro Val  Ser Arg Arg Arg Ser  Arg Ser Arg Thr Ser  Val Thr Arg 
    1895                 1900                 1905             


Arg Arg  Ser Arg Ser Arg Ala  Ser Pro Val Ser Arg  Arg Arg Ser 
    1910                 1915                 1920             


Arg Ser  Arg Thr Pro Pro Val  Thr Arg Arg Arg Ser  Arg Ser Arg 
    1925                 1930                 1935             


Thr Pro  Thr Thr Arg Arg Arg  Ser Arg Ser Arg Thr  Pro Pro Val 
    1940                 1945                 1950             


Thr Arg  Arg Arg Ser Arg Ser  Arg Thr Pro Pro Val  Thr Arg Arg 
    1955                 1960                 1965             


Arg Ser  Arg Ser Arg Thr Ser  Pro Ile Thr Arg Arg  Arg Ser Arg 
    1970                 1975                 1980             


Ser Arg  Thr Ser Pro Val Thr  Arg Arg Arg Ser Arg  Ser Arg Thr 
    1985                 1990                 1995             


Ser Pro  Val Thr Arg Arg Arg  Ser Arg Ser Arg Thr  Ser Pro Val 
    2000                 2005                 2010             


Thr Arg  Arg Arg Ser Arg Ser  Arg Thr Pro Pro Ala  Ile Arg Arg 
    2015                 2020                 2025             


Arg Ser  Arg Ser Arg Thr Pro  Leu Leu Pro Arg Lys  Arg Ser Arg 
    2030                 2035                 2040             


Ser Arg  Ser Pro Leu Ala Ile  Arg Arg Arg Ser Arg  Ser Arg Thr 
    2045                 2050                 2055             


Pro Arg  Thr Ala Arg Gly Lys  Arg Ser Leu Thr Arg  Ser Pro Pro 
    2060                 2065                 2070             


Ala Ile  Arg Arg Arg Ser Ala  Ser Gly Ser Ser Ser  Asp Arg Ser 
    2075                 2080                 2085             


Arg Ser  Ala Thr Pro Pro Ala  Thr Arg Asn His Ser  Gly Ser Arg 
    2090                 2095                 2100             


Thr Pro  Pro Val Ala Leu Asn  Ser Ser Arg Met Ser  Cys Phe Ser 
    2105                 2110                 2115             


Arg Pro  Ser Met Ser Pro Thr  Pro Leu Asp Arg Cys  Arg Ser Pro 
    2120                 2125                 2130             


Gly Met  Leu Glu Pro Leu Gly  Ser Ser Arg Thr Pro  Met Ser Val 
    2135                 2140                 2145             


Leu Gln  Gln Ala Gly Gly Ser  Met Met Asp Gly Pro  Gly Pro Arg 
    2150                 2155                 2160             


Ile Pro  Asp His Gln Arg Thr  Ser Val Pro Glu Asn  His Ala Gln 
    2165                 2170                 2175             


Ser Arg  Ile Ala Leu Ala Leu  Thr Ala Ile Ser Leu  Gly Thr Ala 
    2180                 2185                 2190             


Arg Pro  Pro Pro Ser Met Ser  Ala Ala Gly Leu Ala  Ala Arg Met 
    2195                 2200                 2205             


Ser Gln  Val Pro Ala Pro Val  Pro Leu Met Ser Leu  Arg Thr Ala 
    2210                 2215                 2220             


Pro Ala  Ala Asn Leu Ala Ser  Arg Ile Pro Ala Ala  Ser Ala Ala 
    2225                 2230                 2235             


Ala Met  Asn Leu Ala Ser Ala  Arg Thr Pro Ala Ile  Pro Thr Ala 
    2240                 2245                 2250             


Val Asn  Leu Ala Asp Ser Arg  Thr Pro Ala Ala Ala  Ala Ala Met 
    2255                 2260                 2265             


Asn Leu  Ala Ser Pro Arg Thr  Ala Val Ala Pro Ser  Ala Val Asn 
    2270                 2275                 2280             


Leu Ala  Asp Pro Arg Thr Pro  Thr Ala Pro Ala Val  Asn Leu Ala 
    2285                 2290                 2295             


Gly Ala  Arg Thr Pro Ala Ala  Leu Ala Ala Leu Ser  Leu Thr Gly 
    2300                 2305                 2310             


Ser Gly  Thr Pro Pro Thr Ala  Ala Asn Tyr Pro Ser  Ser Ser Arg 
    2315                 2320                 2325             


Thr Pro  Gln Ala Pro Ala Ser  Ala Asn Leu Val Gly  Pro Arg Ser 
    2330                 2335                 2340             


Ala His  Ala Thr Ala Pro Val  Asn Ile Ala Gly Ser  Arg Thr Ala 
    2345                 2350                 2355             


Ala Ala  Leu Ala Pro Ala Ser  Leu Thr Ser Ala Arg  Met Ala Pro 
    2360                 2365                 2370             


Ala Leu  Ser Gly Ala Asn Leu  Thr Ser Pro Arg Val  Pro Leu Ser 
    2375                 2380                 2385             


Ala Tyr  Glu Arg Val Ser Gly  Arg Thr Ser Pro Pro  Leu Leu Asp 
    2390                 2395                 2400             


Arg Ala  Arg Ser Arg Thr Pro  Pro Ser Ala Pro Ser  Gln Ser Arg 
    2405                 2410                 2415             


Met Thr  Ser Glu Arg Ala Pro  Ser Pro Ser Ser Arg  Met Gly Gln 
    2420                 2425                 2430             


Ala Pro  Ser Gln Ser Leu Leu  Pro Pro Ala Gln Asp  Gln Pro Arg 
    2435                 2440                 2445             


Ser Pro  Val Pro Ser Ala Phe  Ser Asp Gln Ser Arg  Cys Leu Ile 
    2450                 2455                 2460             


Ala Gln  Thr Thr Pro Val Ala  Gly Ser Gln Ser Leu  Ser Ser Gly 
    2465                 2470                 2475             


Ala Val  Ala Thr Thr Thr Ser  Ser Ala Gly Asp His  Asn Gly Met 
    2480                 2485                 2490             


Leu Ser  Val Pro Ala Pro Gly  Val Pro His Ser Asp  Val Gly Glu 
    2495                 2500                 2505             


Pro Pro  Ala Ser Thr Gly Ala  Gln Gln Pro Ser Ala  Leu Ala Ala 
    2510                 2515                 2520             


Leu Gln  Pro Ala Lys Glu Arg  Arg Ser Ser Ser Ser  Ser Ser Ser 
    2525                 2530                 2535             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2540                 2545                 2550             


Ser Ser  Ser Gly Ser Ser Ser  Ser Asp Ser Glu Gly  Ser Ser Leu 
    2555                 2560                 2565             


Pro Val  Gln Pro Glu Val Ala  Leu Lys Arg Val Pro  Ser Pro Thr 
    2570                 2575                 2580             


Pro Ala  Pro Lys Glu Ala Val  Arg Glu Gly Arg Pro  Pro Glu Pro 
    2585                 2590                 2595             


Thr Pro  Ala Lys Arg Lys Arg  Arg Ser Ser Ser Ser  Ser Ser Ser 
    2600                 2605                 2610             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2615                 2620                 2625             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2630                 2635                 2640             


Ser Ser  Ser Ser Ser Pro Ser  Pro Ala Lys Pro Gly  Pro Gln Ala 
    2645                 2650                 2655             


Leu Pro  Lys Pro Ala Ser Pro  Lys Lys Pro Pro Pro  Gly Glu Arg 
    2660                 2665                 2670             


Arg Ser  Arg Ser Pro Arg Lys  Pro Ile Asp Ser Leu  Arg Asp Ser 
    2675                 2680                 2685             


Arg Ser  Leu Ser Tyr Ser Pro  Val Glu Arg Arg Arg  Pro Ser Pro 
    2690                 2695                 2700             


Gln Pro  Ser Pro Arg Asp Gln  Gln Ser Ser Ser Ser  Glu Arg Gly 
    2705                 2710                 2715             


Ser Arg  Arg Gly Gln Arg Gly  Asp Ser Arg Ser Pro  Ser His Lys 
    2720                 2725                 2730             


Arg Arg  Arg Glu Thr Pro Ser  Pro Arg Pro Met Arg  His Arg Ser 
    2735                 2740                 2745             


Ser Arg  Ser Pro 
    2750         


<210>  9
<211>  485
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8N6W0

<400>  9

Met Ala Arg Leu Thr Glu Ser Glu Ala Arg Arg Gln Gln Gln Gln Leu 
1               5                   10                  15      


Leu Gln Pro Arg Pro Ser Pro Val Gly Ser Ser Gly Pro Glu Pro Pro 
            20                  25                  30          


Gly Gly Gln Pro Asp Gly Met Lys Asp Leu Asp Ala Ile Lys Leu Phe 
        35                  40                  45              


Val Gly Gln Ile Pro Arg His Leu Asp Glu Lys Asp Leu Lys Pro Leu 
    50                  55                  60                  


Phe Glu Gln Phe Gly Arg Ile Tyr Glu Leu Thr Val Leu Lys Asp Pro 
65                  70                  75                  80  


Tyr Thr Gly Met His Lys Gly Cys Ala Phe Leu Thr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Ala Ile Lys Ala Gln Thr Ala Leu His Glu Gln Lys Thr Leu 
            100                 105                 110         


Pro Gly Met Ala Arg Pro Ile Gln Val Lys Pro Ala Asp Ser Glu Ser 
        115                 120                 125             


Arg Gly Gly Arg Asp Arg Lys Leu Phe Val Gly Met Leu Asn Lys Gln 
    130                 135                 140                 


Gln Ser Glu Glu Asp Val Leu Arg Leu Phe Gln Pro Phe Gly Val Ile 
145                 150                 155                 160 


Asp Glu Cys Thr Val Leu Arg Gly Pro Asp Gly Ser Ser Lys Gly Cys 
                165                 170                 175     


Ala Phe Val Lys Phe Ser Ser His Thr Glu Ala Gln Ala Ala Ile His 
            180                 185                 190         


Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser Leu Val 
        195                 200                 205             


Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Leu Arg Arg Met Gln 
    210                 215                 220                 


Gln Met Val Gly Gln Leu Gly Ile Leu Thr Pro Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Phe Ser Pro Tyr Ser Ala Tyr Ala Gln Ala Leu Met Gln Gln Gln Thr 
                245                 250                 255     


Thr Val Leu Ser Thr Ser Gly Ser Tyr Leu Ser Pro Gly Val Ala Phe 
            260                 265                 270         


Ser Pro Cys His Ile Gln Gln Ile Gly Ala Val Ser Leu Asn Gly Leu 
        275                 280                 285             


Pro Ala Thr Pro Ile Ala Pro Ala Ser Gly Leu His Ser Pro Pro Leu 
    290                 295                 300                 


Leu Gly Thr Thr Ala Val Pro Gly Leu Val Ala Pro Ile Thr Asn Gly 
305                 310                 315                 320 


Phe Ala Gly Val Val Pro Phe Pro Gly Gly His Pro Ala Leu Glu Thr 
                325                 330                 335     


Val Tyr Ala Asn Gly Leu Val Pro Tyr Pro Ala Gln Ser Pro Thr Val 
            340                 345                 350         


Ala Glu Thr Leu His Pro Ala Phe Ser Gly Val Gln Gln Tyr Thr Ala 
        355                 360                 365             


Met Tyr Pro Thr Ala Ala Ile Thr Pro Ile Ala His Ser Val Pro Gln 
    370                 375                 380                 


Pro Pro Pro Leu Leu Gln Gln Gln Gln Arg Glu Gly Pro Glu Gly Cys 
385                 390                 395                 400 


Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Thr Glu Leu 
                405                 410                 415     


Thr Gln Met Phe Leu Pro Phe Gly Asn Ile Ile Ser Ser Lys Val Phe 
            420                 425                 430         


Met Asp Arg Ala Thr Asn Gln Ser Lys Cys Phe Gly Phe Val Ser Phe 
        435                 440                 445             


Asp Asn Pro Ala Ser Ala Gln Ala Ala Ile Gln Ala Met Asn Gly Phe 
    450                 455                 460                 


Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp 
465                 470                 475                 480 


Pro Gly His Pro Tyr 
                485 


<210>  10
<211>  1746
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9H792

<400>  10

Met Ser Ala Cys Asn Thr Phe Thr Glu His Val Trp Lys Pro Gly Glu 
1               5                   10                  15      


Cys Lys Asn Cys Phe Lys Pro Lys Ser Leu His Gln Leu Pro Pro Asp 
            20                  25                  30          


Pro Glu Lys Ala Pro Ile Thr His Gly Asn Val Lys Thr Asn Ala Asn 
        35                  40                  45              


His Ser Asn Asn His Arg Ile Arg Asn Thr Gly Asn Phe Arg Pro Pro 
    50                  55                  60                  


Val Ala Lys Lys Pro Thr Ile Ala Val Lys Pro Thr Met Ile Val Ala 
65                  70                  75                  80  


Asp Gly Gln Ser Ile Cys Gly Glu Leu Ser Ile Gln Glu His Cys Glu 
                85                  90                  95      


Asn Lys Pro Val Ile Ile Gly Trp Asn Arg Asn Arg Ala Ala Leu Ser 
            100                 105                 110         


Gln Lys Pro Leu Asn Asn Asn Asn Glu Asp Asp Glu Gly Ile Ser His 
        115                 120                 125             


Val Pro Lys Pro Tyr Gly Asn Asn Asp Ser Ala Lys Lys Met Ser Asp 
    130                 135                 140                 


Asn Asn Asn Gly Leu Thr Glu Val Leu Lys Glu Ile Ala Gly Leu Asp 
145                 150                 155                 160 


Thr Ala Pro Gln Ile Arg Gly Asn Glu Thr Asn Ser Arg Glu Thr Phe 
                165                 170                 175     


Leu Gly Arg Ile Asn Asp Cys Tyr Lys Arg Ser Leu Glu Arg Lys Leu 
            180                 185                 190         


Pro Pro Ser Cys Met Ile Gly Gly Ile Lys Glu Thr Gln Gly Lys His 
        195                 200                 205             


Val Ile Leu Ser Gly Ser Thr Glu Val Ile Ser Asn Glu Gly Gly Arg 
    210                 215                 220                 


Phe Cys Tyr Pro Glu Phe Ser Ser Gly Glu Glu Ser Glu Glu Asp Val 
225                 230                 235                 240 


Leu Phe Ser Asn Met Glu Glu Glu His Glu Ser Trp Asp Glu Ser Asp 
                245                 250                 255     


Glu Glu Leu Leu Ala Met Glu Ile Arg Met Arg Gly Gln Pro Arg Phe 
            260                 265                 270         


Ala Asn Phe Arg Ala Asn Thr Leu Ser Pro Val Arg Phe Phe Val Asp 
        275                 280                 285             


Lys Lys Trp Asn Thr Ile Pro Leu Arg Asn Lys Ser Leu Gln Arg Ile 
    290                 295                 300                 


Cys Ala Val Asp Tyr Asp Asp Ser Tyr Asp Glu Ile Leu Asn Gly Tyr 
305                 310                 315                 320 


Glu Glu Asn Ser Val Val Ser Tyr Gly Gln Gly Ser Ile Gln Ser Met 
                325                 330                 335     


Val Ser Ser Asp Ser Thr Ser Pro Asp Ser Ser Leu Thr Glu Glu Ser 
            340                 345                 350         


Arg Ser Glu Thr Ala Ser Ser Leu Ser Gln Lys Ile Cys Asn Gly Gly 
        355                 360                 365             


Leu Ser Pro Gly Asn Pro Gly Asp Ser Lys Asp Met Lys Glu Ile Glu 
    370                 375                 380                 


Pro Asn Tyr Glu Ser Pro Ser Ser Asn Asn Gln Asp Lys Asp Ser Ser 
385                 390                 395                 400 


Gln Ala Ser Lys Ser Ser Ile Lys Val Pro Glu Thr His Lys Ala Val 
                405                 410                 415     


Leu Ala Leu Arg Leu Glu Glu Lys Asp Gly Lys Ile Ala Val Gln Thr 
            420                 425                 430         


Glu Lys Glu Glu Ser Lys Ala Ser Thr Asp Val Ala Gly Gln Ala Val 
        435                 440                 445             


Thr Ile Asn Leu Val Pro Thr Glu Glu Gln Ala Lys Pro Tyr Arg Val 
    450                 455                 460                 


Val Asn Leu Glu Gln Pro Leu Cys Lys Pro Tyr Thr Val Val Asp Val 
465                 470                 475                 480 


Ser Ala Ala Met Ala Ser Glu His Leu Glu Gly Pro Val Asn Ser Pro 
                485                 490                 495     


Lys Thr Lys Ser Ser Ser Ser Thr Pro Asn Ser Pro Val Thr Ser Ser 
            500                 505                 510         


Ser Leu Thr Pro Gly Gln Ile Ser Ala His Phe Gln Lys Ser Ser Ala 
        515                 520                 525             


Ile Arg Tyr Gln Glu Val Trp Thr Ser Ser Thr Ser Pro Arg Gln Lys 
    530                 535                 540                 


Ile Pro Lys Val Glu Leu Ile Thr Ser Gly Thr Gly Pro Asn Val Pro 
545                 550                 555                 560 


Pro Arg Lys Asn Cys His Lys Ser Ala Pro Thr Ser Pro Thr Ala Thr 
                565                 570                 575     


Asn Ile Ser Ser Lys Thr Ile Pro Val Lys Ser Pro Asn Leu Ser Glu 
            580                 585                 590         


Ile Lys Phe Asn Ser Tyr Asn Asn Ala Gly Met Pro Pro Phe Pro Ile 
        595                 600                 605             


Ile Ile His Asp Glu Pro Thr Tyr Ala Arg Ser Ser Lys Asn Ala Ile 
    610                 615                 620                 


Lys Val Pro Ile Val Ile Asn Pro Asn Ala Tyr Asp Asn Leu Ala Ile 
625                 630                 635                 640 


Tyr Lys Ser Phe Leu Gly Thr Ser Gly Glu Leu Ser Val Lys Glu Lys 
                645                 650                 655     


Thr Thr Ser Val Ile Ser His Thr Tyr Glu Glu Ile Glu Thr Glu Ser 
            660                 665                 670         


Lys Val Pro Asp Asn Thr Thr Ser Lys Thr Thr Asp Cys Leu Gln Thr 
        675                 680                 685             


Lys Gly Phe Ser Asn Ser Thr Glu His Lys Arg Gly Ser Val Ala Gln 
    690                 695                 700                 


Lys Val Gln Glu Phe Asn Asn Cys Leu Asn Arg Gly Gln Ser Ser Pro 
705                 710                 715                 720 


Gln Arg Ser Tyr Ser Ser Ser His Ser Ser Pro Ala Lys Ile Gln Arg 
                725                 730                 735     


Ala Thr Gln Glu Pro Val Ala Lys Ile Glu Gly Thr Gln Glu Ser Gln 
            740                 745                 750         


Met Val Gly Ser Ser Ser Thr Arg Glu Lys Ala Ser Thr Val Leu Ser 
        755                 760                 765             


Gln Ile Val Ala Ser Ile Gln Pro Pro Gln Ser Pro Pro Glu Thr Pro 
    770                 775                 780                 


Gln Ser Gly Pro Lys Ala Cys Ser Val Glu Glu Leu Tyr Ala Ile Pro 
785                 790                 795                 800 


Pro Asp Ala Asp Val Ala Lys Ser Thr Pro Lys Ser Thr Pro Val Arg 
                805                 810                 815     


Pro Lys Ser Leu Phe Thr Ser Gln Pro Ser Gly Glu Ala Glu Ala Pro 
            820                 825                 830         


Gln Thr Thr Asp Ser Pro Thr Thr Lys Val Gln Lys Asp Pro Ser Ile 
        835                 840                 845             


Lys Pro Val Thr Pro Ser Pro Ser Lys Leu Val Thr Ser Pro Gln Ser 
    850                 855                 860                 


Glu Pro Pro Ala Pro Phe Pro Pro Pro Arg Ser Thr Ser Ser Pro Tyr 
865                 870                 875                 880 


His Ala Gly Asn Leu Leu Gln Arg His Phe Thr Asn Trp Thr Lys Pro 
                885                 890                 895     


Thr Ser Pro Thr Arg Ser Thr Glu Ala Glu Ser Val Leu His Ser Glu 
            900                 905                 910         


Gly Ser Arg Arg Ala Ala Asp Ala Lys Pro Lys Arg Trp Ile Ser Phe 
        915                 920                 925             


Lys Ser Phe Phe Arg Arg Arg Lys Thr Asp Glu Glu Asp Asp Lys Glu 
    930                 935                 940                 


Lys Glu Arg Glu Lys Gly Lys Leu Val Gly Leu Asp Gly Thr Val Ile 
945                 950                 955                 960 


His Met Leu Pro Pro Pro Pro Val Gln Arg His His Trp Phe Thr Glu 
                965                 970                 975     


Ala Lys Gly Glu Ser Ser Glu Lys Pro Ala Ile Val Phe Met Tyr Arg 
            980                 985                 990         


Cys Asp Pro Ala Gln Gly Gln Leu  Ser Val Asp Gln Ser  Lys Ala Arg 
        995                 1000                 1005             


Thr Asp  Gln Ala Ala Val Met  Glu Lys Gly Arg Ala  Glu Asn Ala 
    1010                 1015                 1020             


Leu Leu  Gln Asp Ser Glu Lys  Lys Arg Ser His Ser  Ser Pro Ser 
    1025                 1030                 1035             


Gln Ile  Pro Lys Lys Ile Leu  Ser His Met Thr His  Glu Val Thr 
    1040                 1045                 1050             


Glu Asp  Phe Ser Pro Arg Asp  Pro Arg Thr Val Val  Gly Lys Gln 
    1055                 1060                 1065             


Asp Gly  Arg Gly Cys Thr Ser  Val Thr Thr Ala Leu  Ser Leu Pro 
    1070                 1075                 1080             


Glu Leu  Glu Arg Glu Asp Gly  Lys Glu Asp Ile Ser  Asp Pro Met 
    1085                 1090                 1095             


Asp Pro  Asn Pro Cys Ser Ala  Thr Tyr Ser Asn Leu  Gly Gln Ser 
    1100                 1105                 1110             


Arg Ala  Ala Met Ile Pro Pro  Lys Gln Pro Arg Gln  Pro Lys Gly 
    1115                 1120                 1125             


Ala Val  Asp Asp Ala Ile Ala  Phe Gly Gly Lys Thr  Asp Gln Glu 
    1130                 1135                 1140             


Ala Pro  Asn Ala Ser Gln Pro  Thr Pro Pro Pro Leu  Pro Lys Lys 
    1145                 1150                 1155             


Met Ile  Ile Arg Ala Asn Thr  Glu Pro Ile Ser Lys  Asp Leu Gln 
    1160                 1165                 1170             


Lys Ser  Met Glu Ser Ser Leu  Cys Val Met Ala Asn  Pro Thr Tyr 
    1175                 1180                 1185             


Asp Ile  Asp Pro Asn Trp Asp  Ala Ser Ser Ala Gly  Ser Ser Ile 
    1190                 1195                 1200             


Ser Tyr  Glu Leu Lys Gly Leu  Asp Ile Glu Ser Tyr  Asp Ser Leu 
    1205                 1210                 1215             


Glu Arg  Pro Leu Arg Lys Glu  Arg Pro Val Pro Ser  Ala Ala Asn 
    1220                 1225                 1230             


Ser Ile  Ser Ser Leu Thr Thr  Leu Ser Ile Lys Asp  Arg Phe Ser 
    1235                 1240                 1245             


Asn Ser  Met Glu Ser Leu Ser  Ser Arg Arg Gly Pro  Ser Cys Arg 
    1250                 1255                 1260             


Gln Gly  Arg Gly Ile Gln Lys  Pro Gln Arg Gln Ala  Leu Tyr Arg 
    1265                 1270                 1275             


Gly Leu  Glu Asn Arg Glu Glu  Val Val Gly Lys Ile  Arg Ser Leu 
    1280                 1285                 1290             


His Thr  Asp Ala Leu Lys Lys  Leu Ala Val Lys Cys  Glu Asp Leu 
    1295                 1300                 1305             


Phe Met  Ala Gly Gln Lys Asp  Gln Leu Arg Phe Gly  Val Asp Ser 
    1310                 1315                 1320             


Trp Ser  Asp Phe Arg Leu Thr  Ser Asp Lys Pro Cys  Cys Glu Ala 
    1325                 1330                 1335             


Gly Asp  Ala Val Tyr Tyr Thr  Ala Ser Tyr Ala Lys  Asp Pro Leu 
    1340                 1345                 1350             


Asn Asn  Tyr Ala Val Lys Ile  Cys Lys Ser Lys Ala  Lys Glu Ser 
    1355                 1360                 1365             


Gln Gln  Tyr Tyr His Ser Leu  Ala Val Arg Gln Ser  Leu Ala Val 
    1370                 1375                 1380             


His Phe  Asn Ile Gln Gln Asp  Cys Gly His Phe Leu  Ala Glu Val 
    1385                 1390                 1395             


Pro Asn  Arg Leu Leu Pro Trp  Glu Asp Pro Asp Asp  Pro Glu Lys 
    1400                 1405                 1410             


Asp Glu  Asp Asp Met Glu Glu  Thr Glu Glu Asp Ala  Lys Gly Glu 
    1415                 1420                 1425             


Thr Asp  Gly Lys Asn Pro Lys  Pro Cys Ser Glu Ala  Ala Ser Ser 
    1430                 1435                 1440             


Gln Lys  Glu Asn Gln Gly Val  Met Ser Lys Lys Gln  Arg Ser His 
    1445                 1450                 1455             


Val Val  Val Ile Thr Arg Glu  Val Pro Cys Leu Thr  Val Ala Asp 
    1460                 1465                 1470             


Phe Val  Arg Asp Ser Leu Ala  Gln His Gly Lys Ser  Pro Asp Leu 
    1475                 1480                 1485             


Tyr Glu  Arg Gln Val Cys Leu  Leu Leu Leu Gln Leu  Cys Ser Gly 
    1490                 1495                 1500             


Leu Glu  His Leu Lys Pro Tyr  His Val Thr His Cys  Asp Leu Arg 
    1505                 1510                 1515             


Leu Glu  Asn Leu Leu Leu Val  His Tyr Gln Pro Gly  Gly Thr Ala 
    1520                 1525                 1530             


Gln Gly  Phe Gly Pro Ala Glu  Pro Ser Pro Thr Ser  Ser Tyr Pro 
    1535                 1540                 1545             


Thr Arg  Leu Ile Val Ser Asn  Phe Ser Gln Ala Lys  Gln Lys Ser 
    1550                 1555                 1560             


His Leu  Val Asp Pro Glu Ile  Leu Arg Asp Gln Ser  Arg Leu Ala 
    1565                 1570                 1575             


Pro Glu  Ile Ile Thr Ala Thr  Gln Tyr Lys Lys Cys  Asp Glu Phe 
    1580                 1585                 1590             


Gln Thr  Gly Ile Leu Ile Tyr  Glu Met Leu His Leu  Pro Asn Pro 
    1595                 1600                 1605             


Phe Asp  Glu Asn Pro Glu Leu  Lys Glu Arg Glu Tyr  Thr Arg Ala 
    1610                 1615                 1620             


Asp Leu  Pro Arg Ile Pro Phe  Arg Ser Pro Tyr Ser  Arg Gly Leu 
    1625                 1630                 1635             


Gln Gln  Leu Ala Ser Cys Leu  Leu Asn Pro Asn Pro  Ser Glu Arg 
    1640                 1645                 1650             


Ile Leu  Ile Ser Asp Ala Lys  Gly Ile Leu Gln Cys  Leu Leu Trp 
    1655                 1660                 1665             


Gly Pro  Arg Glu Asp Leu Phe  Gln Thr Phe Thr Ala  Cys Pro Ser 
    1670                 1675                 1680             


Leu Val  Gln Arg Asn Thr Leu  Leu Gln Asn Trp Leu  Asp Ile Lys 
    1685                 1690                 1695             


Arg Thr  Leu Leu Met Ile Lys  Phe Ala Glu Lys Ser  Leu Asp Arg 
    1700                 1705                 1710             


Glu Gly  Gly Ile Ser Leu Glu  Asp Trp Leu Cys Ala  Gln Tyr Leu 
    1715                 1720                 1725             


Ala Phe  Ala Thr Thr Asp Ser  Leu Ser Cys Ile Val  Lys Ile Leu 
    1730                 1735                 1740             


Gln His  Arg 
    1745     


<210>  11
<211>  397
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9H497

<400>  11

Met Leu Arg Gly Pro Trp Arg Gln Leu Trp Leu Phe Phe Leu Leu Leu 
1               5                   10                  15      


Leu Pro Gly Ala Pro Glu Pro Arg Gly Ala Ser Arg Pro Trp Glu Gly 
            20                  25                  30          


Thr Asp Glu Pro Gly Ser Ala Trp Ala Trp Pro Gly Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Gln Leu Arg Ala Ala Gly Ala Leu Ser Lys Arg Tyr Trp Thr 
    50                  55                  60                  


Leu Phe Ser Cys Gln Val Trp Pro Asp Asp Cys Asp Glu Asp Glu Glu 
65                  70                  75                  80  


Ala Ala Thr Gly Pro Leu Gly Trp Arg Leu Pro Leu Leu Gly Gln Arg 
                85                  90                  95      


Tyr Leu Asp Leu Leu Thr Thr Trp Tyr Cys Ser Phe Lys Asp Cys Cys 
            100                 105                 110         


Pro Arg Gly Asp Cys Arg Ile Ser Asn Asn Phe Thr Gly Leu Glu Trp 
        115                 120                 125             


Asp Leu Asn Val Arg Leu His Gly Gln His Leu Val Gln Gln Leu Val 
    130                 135                 140                 


Leu Arg Thr Val Arg Gly Tyr Leu Glu Thr Pro Gln Pro Glu Lys Ala 
145                 150                 155                 160 


Leu Ala Leu Ser Phe His Gly Trp Ser Gly Thr Gly Lys Asn Phe Val 
                165                 170                 175     


Ala Arg Met Leu Val Glu Asn Leu Tyr Arg Asp Gly Leu Met Ser Asp 
            180                 185                 190         


Cys Val Arg Met Phe Ile Ala Thr Phe His Phe Pro His Pro Lys Tyr 
        195                 200                 205             


Val Asp Leu Tyr Lys Glu Gln Leu Met Ser Gln Ile Arg Glu Thr Gln 
    210                 215                 220                 


Gln Leu Cys His Gln Thr Leu Phe Ile Phe Asp Glu Ala Glu Lys Leu 
225                 230                 235                 240 


His Pro Gly Leu Leu Glu Val Leu Gly Pro His Leu Glu Arg Arg Ala 
                245                 250                 255     


Pro Glu Gly His Arg Ala Glu Ser Pro Trp Thr Ile Phe Leu Phe Leu 
            260                 265                 270         


Ser Asn Leu Arg Gly Asp Ile Ile Asn Glu Val Val Leu Lys Leu Leu 
        275                 280                 285             


Lys Ala Gly Trp Ser Arg Glu Glu Ile Thr Met Glu His Leu Glu Pro 
    290                 295                 300                 


His Leu Gln Ala Glu Ile Val Glu Thr Ile Asp Asn Gly Phe Gly His 
305                 310                 315                 320 


Ser Arg Leu Val Lys Glu Asn Leu Ile Asp Tyr Phe Ile Pro Phe Leu 
                325                 330                 335     


Pro Leu Glu Tyr Arg His Val Arg Leu Cys Ala Arg Asp Ala Phe Leu 
            340                 345                 350         


Ser Gln Glu Leu Leu Tyr Lys Glu Glu Thr Leu Asp Glu Ile Ala Gln 
        355                 360                 365             


Met Met Val Tyr Val Pro Lys Glu Glu Gln Leu Phe Ser Ser Gln Gly 
    370                 375                 380                 


Cys Lys Ser Ile Ser Gln Arg Ile Asn Tyr Phe Leu Ser 
385                 390                 395         


<210>  12
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9UE35

<400>  12

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro 
        115 


<210>  13
<211>  305
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  O00743

<400>  13

Met Ala Pro Leu Asp Leu Asp Lys Tyr Val Glu Ile Ala Arg Leu Cys 
1               5                   10                  15      


Lys Tyr Leu Pro Glu Asn Asp Leu Lys Arg Leu Cys Asp Tyr Val Cys 
            20                  25                  30          


Asp Leu Leu Leu Glu Glu Ser Asn Val Gln Pro Val Ser Thr Pro Val 
        35                  40                  45              


Thr Val Cys Gly Asp Ile His Gly Gln Phe Tyr Asp Leu Cys Glu Leu 
    50                  55                  60                  


Phe Arg Thr Gly Gly Gln Val Pro Asp Thr Asn Tyr Ile Phe Met Gly 
65                  70                  75                  80  


Asp Phe Val Asp Arg Gly Tyr Tyr Ser Leu Glu Thr Phe Thr Tyr Leu 
                85                  90                  95      


Leu Ala Leu Lys Ala Lys Trp Pro Asp Arg Ile Thr Leu Leu Arg Gly 
            100                 105                 110         


Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe Tyr Asp Glu 
        115                 120                 125             


Cys Gln Thr Lys Tyr Gly Asn Ala Asn Ala Trp Arg Tyr Cys Thr Lys 
    130                 135                 140                 


Val Phe Asp Met Leu Thr Val Ala Ala Leu Ile Asp Glu Gln Ile Leu 
145                 150                 155                 160 


Cys Val His Gly Gly Leu Ser Pro Asp Ile Lys Thr Leu Asp Gln Ile 
                165                 170                 175     


Arg Thr Ile Glu Arg Asn Gln Glu Ile Pro His Lys Gly Ala Phe Cys 
            180                 185                 190         


Asp Leu Val Trp Ser Asp Pro Glu Asp Val Asp Thr Trp Ala Ile Ser 
        195                 200                 205             


Pro Arg Gly Ala Gly Trp Leu Phe Gly Ala Lys Val Thr Asn Glu Phe 
    210                 215                 220                 


Val His Ile Asn Asn Leu Lys Leu Ile Cys Arg Ala His Gln Leu Val 
225                 230                 235                 240 


His Glu Gly Tyr Lys Phe Met Phe Asp Glu Lys Leu Val Thr Val Trp 
                245                 250                 255     


Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Ile Ala Ser Ile Met 
            260                 265                 270         


Val Phe Lys Asp Val Asn Thr Arg Glu Pro Lys Leu Phe Arg Ala Val 
        275                 280                 285             


Pro Asp Ser Glu Arg Val Ile Pro Pro Arg Thr Thr Thr Pro Tyr Phe 
    290                 295                 300                 


Leu 
305 


<210>  14
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8WXF8

<400>  14

Met Ala Leu Ser Gly Ser Thr Pro Ala Pro Cys Trp Glu Glu Asp Glu 
1               5                   10                  15      


Cys Leu Asp Tyr Tyr Gly Met Leu Ser Leu His Arg Met Phe Glu Val 
            20                  25                  30          


Val Gly Gly Gln Leu Thr Glu Cys Glu Leu Glu Leu Leu Ala Phe Leu 
        35                  40                  45              


Leu Asp Glu Ala Pro Gly Ala Ala Gly Gly Leu Ala Arg Ala Arg Ser 
    50                  55                  60                  


Gly Leu Glu Leu Leu Leu Glu Leu Glu Arg Arg Gly Gln Cys Asp Glu 
65                  70                  75                  80  


Ser Asn Leu Arg Leu Leu Gly Gln Leu Leu Arg Val Leu Ala Arg His 
                85                  90                  95      


Asp Leu Leu Pro His Leu Ala Arg Lys Arg Arg Arg Pro Val Ser Pro 
            100                 105                 110         


Glu Arg Tyr Ser Tyr Gly Thr Ser Ser Ser Ser Lys Arg Thr Glu Gly 
        115                 120                 125             


Ser Cys Arg Arg Arg Arg Gln Ser Ser Ser Ser Ala Asn Ser Gln Gln 
    130                 135                 140                 


Gly Gln Trp Glu Thr Gly Ser Pro Pro Thr Lys Arg Gln Arg Arg Ser 
145                 150                 155                 160 


Arg Gly Arg Pro Ser Gly Gly Ala Arg Arg Arg Arg Arg Gly Ala Pro 
                165                 170                 175     


Ala Ala Pro Gln Gln Gln Ser Glu Pro Ala Arg Pro Ser Ser Glu Gly 
            180                 185                 190         


Lys Val Thr Cys Asp Ile Arg Leu Arg Val Arg Ala Glu Tyr Cys Glu 
        195                 200                 205             


His Gly Pro Ala Leu Glu Gln Gly Val Ala Ser Arg Arg Pro Gln Ala 
    210                 215                 220                 


Leu Ala Arg Gln Leu Asp Val Phe Gly Gln Ala Thr Ala Val Leu Arg 
225                 230                 235                 240 


Ser Arg Asp Leu Gly Ser Val Val Cys Asp Ile Lys Phe Ser Glu Leu 
                245                 250                 255     


Ser Tyr Leu Asp Ala Phe Trp Gly Asp Tyr Leu Ser Gly Ala Leu Leu 
            260                 265                 270         


Gln Ala Leu Arg Gly Val Phe Leu Thr Glu Ala Leu Arg Glu Ala Val 
        275                 280                 285             


Gly Arg Glu Ala Val Arg Leu Leu Val Ser Val Asp Glu Ala Asp Tyr 
    290                 295                 300                 


Glu Ala Gly Arg Arg Arg Leu Leu Leu Met Glu Glu Glu Gly Gly Arg 
305                 310                 315                 320 


Arg Pro Thr Glu Ala Ser 
                325     


<210>  15
<211>  684
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  P81274

<400>  15

Met Glu Glu Asn Leu Ile Ser Met Arg Glu Asp His Ser Phe His Val 
1               5                   10                  15      


Arg Tyr Arg Met Glu Ala Ser Cys Leu Glu Leu Ala Leu Glu Gly Glu 
            20                  25                  30          


Arg Leu Cys Lys Ser Gly Asp Cys Arg Ala Gly Val Ser Phe Phe Glu 
        35                  40                  45              


Ala Ala Val Gln Val Gly Thr Glu Asp Leu Lys Thr Leu Ser Ala Ile 
    50                  55                  60                  


Tyr Ser Gln Leu Gly Asn Ala Tyr Phe Tyr Leu His Asp Tyr Ala Lys 
65                  70                  75                  80  


Ala Leu Glu Tyr His His His Asp Leu Thr Leu Ala Arg Thr Ile Gly 
                85                  90                  95      


Asp Gln Leu Gly Glu Ala Lys Ala Ser Gly Asn Leu Gly Asn Thr Leu 
            100                 105                 110         


Lys Val Leu Gly Asn Phe Asp Glu Ala Ile Val Cys Cys Gln Arg His 
        115                 120                 125             


Leu Asp Ile Ser Arg Glu Leu Asn Asp Lys Val Gly Glu Ala Arg Ala 
    130                 135                 140                 


Leu Tyr Asn Leu Gly Asn Val Tyr His Ala Lys Gly Lys Ser Phe Gly 
145                 150                 155                 160 


Cys Pro Gly Pro Gln Asp Val Gly Glu Phe Pro Glu Glu Val Arg Asp 
                165                 170                 175     


Ala Leu Gln Ala Ala Val Asp Phe Tyr Glu Glu Asn Leu Ser Leu Val 
            180                 185                 190         


Thr Ala Leu Gly Asp Arg Ala Ala Gln Gly Arg Ala Phe Gly Asn Leu 
        195                 200                 205             


Gly Asn Thr His Tyr Leu Leu Gly Asn Phe Arg Asp Ala Val Ile Ala 
    210                 215                 220                 


His Glu Gln Arg Leu Leu Ile Ala Lys Glu Phe Gly Asp Lys Ala Ala 
225                 230                 235                 240 


Glu Arg Arg Ala Tyr Ser Asn Leu Gly Asn Ala Tyr Ile Phe Leu Gly 
                245                 250                 255     


Glu Phe Glu Thr Ala Ser Glu Tyr Tyr Lys Lys Thr Leu Leu Leu Ala 
            260                 265                 270         


Arg Gln Leu Lys Asp Arg Ala Val Glu Ala Gln Ser Cys Tyr Ser Leu 
        275                 280                 285             


Gly Asn Thr Tyr Thr Leu Leu Gln Asp Tyr Glu Lys Ala Ile Asp Tyr 
    290                 295                 300                 


His Leu Lys His Leu Ala Ile Ala Gln Glu Leu Asn Asp Arg Ile Gly 
305                 310                 315                 320 


Glu Gly Arg Ala Cys Trp Ser Leu Gly Asn Ala Tyr Thr Ala Leu Gly 
                325                 330                 335     


Asn His Asp Gln Ala Met His Phe Ala Glu Lys His Leu Glu Ile Ser 
            340                 345                 350         


Arg Glu Val Gly Asp Lys Ser Gly Glu Leu Thr Ala Arg Leu Asn Leu 
        355                 360                 365             


Ser Asp Leu Gln Met Val Leu Gly Leu Ser Tyr Ser Thr Asn Asn Ser 
    370                 375                 380                 


Ile Met Ser Glu Asn Thr Glu Ile Asp Ser Ser Leu Asn Gly Val Arg 
385                 390                 395                 400 


Pro Lys Leu Gly Arg Arg His Ser Met Glu Asn Met Glu Leu Met Lys 
                405                 410                 415     


Leu Thr Pro Glu Lys Val Gln Asn Trp Asn Ser Glu Ile Leu Ala Lys 
            420                 425                 430         


Gln Lys Pro Leu Ile Ala Lys Pro Ser Ala Lys Leu Leu Phe Val Asn 
        435                 440                 445             


Arg Leu Lys Gly Lys Lys Tyr Lys Thr Asn Ser Ser Thr Lys Val Leu 
    450                 455                 460                 


Gln Asp Ala Ser Asn Ser Ile Asp His Arg Ile Pro Asn Ser Gln Arg 
465                 470                 475                 480 


Lys Ile Ser Ala Asp Thr Ile Gly Asp Glu Gly Phe Phe Asp Leu Leu 
                485                 490                 495     


Ser Arg Phe Gln Ser Asn Arg Met Asp Asp Gln Arg Cys Cys Leu Gln 
            500                 505                 510         


Glu Lys Asn Cys His Thr Ala Ser Thr Thr Thr Ser Ser Thr Pro Pro 
        515                 520                 525             


Lys Met Met Leu Lys Thr Ser Ser Val Pro Val Val Ser Pro Asn Thr 
    530                 535                 540                 


Asp Glu Phe Leu Asp Leu Leu Ala Ser Ser Gln Ser Arg Arg Leu Asp 
545                 550                 555                 560 


Asp Gln Arg Ala Ser Phe Ser Asn Leu Pro Gly Leu Arg Leu Thr Gln 
                565                 570                 575     


Asn Ser Gln Ser Val Leu Ser His Leu Met Thr Asn Asp Asn Lys Glu 
            580                 585                 590         


Ala Asp Glu Asp Phe Phe Asp Ile Leu Val Lys Cys Gln Gly Ser Arg 
        595                 600                 605             


Leu Asp Asp Gln Arg Cys Ala Pro Pro Pro Ala Thr Thr Lys Gly Pro 
    610                 615                 620                 


Thr Val Pro Asp Glu Asp Phe Phe Ser Leu Ile Leu Arg Ser Gln Gly 
625                 630                 635                 640 


Lys Arg Met Asp Glu Gln Arg Val Leu Leu Gln Arg Asp Gln Asn Arg 
                645                 650                 655     


Asp Thr Asp Phe Gly Leu Lys Asp Phe Leu Gln Asn Asn Ala Leu Leu 
            660                 665                 670         


Glu Phe Lys Asn Ser Gly Lys Lys Ser Ala Asp His 
        675                 680                 


<210>  16
<211>  1087
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8NG08

<400>  16

Met Ala Arg Ser Ser Pro Tyr Leu Arg Gln Leu Gln Gly Pro Leu Leu 
1               5                   10                  15      


Pro Pro Arg Asp Leu Val Glu Glu Asp Asp Asp Tyr Leu Asn Asp Asp 
            20                  25                  30          


Val Glu Glu Asp Glu Glu Ser Val Phe Ile Asp Ala Glu Glu Leu Cys 
        35                  40                  45              


Ser Gly Gly Val Lys Ala Gly Ser Leu Pro Gly Cys Leu Arg Val Ser 
    50                  55                  60                  


Ile Cys Asp Glu Asn Thr Gln Glu Thr Cys Lys Val Phe Gly Arg Phe 
65                  70                  75                  80  


Pro Ile Thr Gly Ala Trp Trp Arg Val Lys Val Gln Val Lys Pro Val 
                85                  90                  95      


Val Gly Ser Arg Ser Tyr Gln Tyr Gln Val Gln Gly Phe Pro Ser Tyr 
            100                 105                 110         


Phe Leu Gln Ser Asp Met Ser Pro Pro Asn Gln Lys His Ile Cys Ala 
        115                 120                 125             


Leu Phe Leu Lys Glu Cys Glu Val Ser Ser Asp Asp Val Asn Lys Phe 
    130                 135                 140                 


Leu Thr Trp Val Lys Glu Val Ser Asn Tyr Lys Asn Leu Asn Phe Glu 
145                 150                 155                 160 


Asn Leu Arg Glu Thr Leu Arg Thr Phe His Lys Glu Thr Gly Arg Lys 
                165                 170                 175     


Asp Gln Lys Gln Pro Thr Gln Asn Gly Gln Glu Glu Leu Phe Leu Asp 
            180                 185                 190         


Asn Glu Met Ser Leu Pro Leu Glu Asn Thr Ile Pro Phe Arg Asn Val 
        195                 200                 205             


Met Thr Ala Leu Gln Phe Pro Lys Ile Met Glu Phe Leu Pro Val Leu 
    210                 215                 220                 


Leu Pro Arg His Phe Lys Trp Ile Ile Gly Ser Gly Ser Lys Glu Met 
225                 230                 235                 240 


Leu Lys Glu Ile Glu Glu Ile Leu Gly Thr His Pro Trp Lys Leu Gly 
                245                 250                 255     


Phe Ser Lys Ile Thr Tyr Arg Glu Trp Lys Leu Leu Arg Cys Glu Ala 
            260                 265                 270         


Ser Trp Ile Ala Phe Cys Gln Cys Glu Ser Leu Leu Gln Leu Met Thr 
        275                 280                 285             


Asp Leu Glu Lys Asn Ala Leu Ile Met Tyr Ser Arg Leu Lys Gln Ile 
    290                 295                 300                 


Cys Arg Glu Asp Gly His Thr Tyr Val Glu Val Asn Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Leu Ser Asn His Met Ser Phe His Ala Ala Ser Glu Ser Leu Lys 
                325                 330                 335     


Phe Leu Lys Asp Ile Gly Val Val Thr Tyr Glu Lys Ser Cys Val Phe 
            340                 345                 350         


Pro Tyr Asp Leu Tyr His Ala Glu Arg Ala Ile Ala Phe Ser Ile Cys 
        355                 360                 365             


Asp Leu Met Lys Lys Pro Pro Trp His Leu Cys Val Asp Val Glu Lys 
    370                 375                 380                 


Val Leu Ala Ser Ile His Thr Thr Lys Pro Glu Asn Ser Ser Asp Asp 
385                 390                 395                 400 


Ala Leu Asn Glu Ser Lys Pro Asp Glu Val Arg Leu Glu Asn Pro Val 
                405                 410                 415     


Asp Val Val Asp Thr Gln Asp Asn Gly Asp His Ile Trp Thr Asn Gly 
            420                 425                 430         


Glu Asn Glu Ile Asn Ala Glu Ile Ser Glu Val Gln Leu Asp Gln Asp 
        435                 440                 445             


Gln Val Glu Val Pro Leu Asp Arg Asp Gln Val Ala Ala Leu Glu Met 
    450                 455                 460                 


Ile Cys Ser Asn Pro Val Thr Val Ile Ser Gly Lys Gly Gly Cys Gly 
465                 470                 475                 480 


Lys Thr Thr Ile Val Ser Arg Leu Phe Lys His Ile Glu Gln Leu Glu 
                485                 490                 495     


Glu Arg Glu Val Lys Lys Ala Cys Glu Asp Phe Glu Gln Asp Gln Asn 
            500                 505                 510         


Ala Ser Glu Glu Trp Ile Thr Phe Thr Glu Gln Ser Gln Leu Glu Ala 
        515                 520                 525             


Asp Lys Ala Ile Glu Val Leu Leu Thr Ala Pro Thr Gly Lys Ala Ala 
    530                 535                 540                 


Gly Leu Leu Arg Gln Lys Thr Gly Leu His Ala Tyr Thr Leu Cys Gln 
545                 550                 555                 560 


Val Asn Tyr Ser Phe Tyr Ser Trp Thr Gln Thr Met Met Thr Thr Asn 
                565                 570                 575     


Lys Pro Trp Lys Phe Ser Ser Val Arg Val Leu Val Val Asp Glu Gly 
            580                 585                 590         


Ser Leu Val Ser Val Gly Ile Phe Lys Ser Val Leu Asn Leu Leu Cys 
        595                 600                 605             


Glu His Ser Lys Leu Ser Lys Leu Ile Ile Leu Gly Asp Ile Arg Gln 
    610                 615                 620                 


Leu Pro Ser Ile Glu Pro Gly Asn Leu Leu Lys Asp Leu Phe Glu Thr 
625                 630                 635                 640 


Leu Lys Ser Arg Asn Cys Ala Ile Glu Leu Lys Thr Asn His Arg Ala 
                645                 650                 655     


Glu Ser Gln Leu Ile Val Asp Asn Ala Thr Arg Ile Ser Arg Arg Gln 
            660                 665                 670         


Phe Pro Lys Phe Asp Ala Glu Leu Asn Ile Ser Asp Asn Pro Thr Leu 
        675                 680                 685             


Pro Ile Ser Ile Gln Asp Lys Thr Phe Ile Phe Val Arg Leu Pro Glu 
    690                 695                 700                 


Glu Asp Ala Ser Ser Gln Ser Ser Lys Thr Asn His His Ser Cys Leu 
705                 710                 715                 720 


Tyr Ser Ala Val Lys Thr Leu Leu Gln Glu Asn Asn Leu Gln Asn Ala 
                725                 730                 735     


Lys Thr Ser Gln Phe Ile Ala Phe Arg Arg Gln Asp Cys Asp Leu Ile 
            740                 745                 750         


Asn Asp Cys Cys Cys Lys His Tyr Thr Gly His Leu Thr Lys Asp His 
        755                 760                 765             


Gln Ser Arg Leu Val Phe Gly Ile Gly Asp Lys Ile Cys Cys Thr Arg 
    770                 775                 780                 


Asn Ala Tyr Leu Ser Asp Leu Leu Pro Glu Asn Ile Ser Gly Ser Gln 
785                 790                 795                 800 


Gln Asn Asn Asp Leu Asp Ala Ser Ser Glu Asp Phe Ser Gly Thr Leu 
                805                 810                 815     


Pro Asp Phe Ala Lys Asn Lys Arg Asp Phe Glu Ser Asn Val Arg Leu 
            820                 825                 830         


Cys Asn Gly Glu Ile Phe Phe Ile Thr Asn Asp Val Thr Asp Val Thr 
        835                 840                 845             


Phe Gly Lys Arg Arg Ser Leu Thr Ile Asn Asn Met Ala Gly Leu Glu 
    850                 855                 860                 


Val Thr Val Asp Phe Lys Lys Leu Met Lys Tyr Cys Arg Ile Lys His 
865                 870                 875                 880 


Ala Trp Ala Arg Thr Ile His Thr Phe Gln Gly Ser Glu Glu Gln Thr 
                885                 890                 895     


Val Val Tyr Val Val Gly Lys Ala Gly Arg Gln His Trp Gln His Val 
            900                 905                 910         


Tyr Thr Ala Val Thr Arg Gly Arg Cys Arg Val Tyr Val Ile Ala Glu 
        915                 920                 925             


Glu Ser Gln Leu Arg Asn Ala Ile Met Lys Asn Ser Phe Pro Arg Lys 
    930                 935                 940                 


Thr Arg Leu Lys His Phe Leu Gln Ser Lys Leu Ser Ser Ser Gly Ala 
945                 950                 955                 960 


Pro Pro Ala Asp Phe Pro Ser Pro Arg Lys Ser Ser Gly Asp Ser Gly 
                965                 970                 975     


Gly Pro Ser Thr Pro Ser Ala Ser Pro Leu Pro Val Val Thr Asp His 
            980                 985                 990         


Ala Met Thr Asn Asp Val Thr Trp  Ser Glu Ala Ser Ser  Pro Asp Glu 
        995                 1000                 1005             


Arg Thr  Leu Thr Phe Ala Glu  Arg Trp Gln Leu Ser  Ser Pro Asp 
    1010                 1015                 1020             


Gly Val  Asp Thr Asp Asp Asp  Leu Pro Lys Ser Arg  Ala Ser Lys 
    1025                 1030                 1035             


Arg Thr  Cys Gly Val Asn Asp  Asp Glu Ser Pro Ser  Lys Ile Phe 
    1040                 1045                 1050             


Met Val  Gly Glu Ser Pro Gln  Val Ser Ser Arg Leu  Gln Asn Leu 
    1055                 1060                 1065             


Arg Leu  Asn Asn Leu Ile Pro  Arg Gln Leu Phe Lys  Pro Thr Asp 
    1070                 1075                 1080             


Asn Gln  Glu Thr 
    1085         


<210>  17
<211>  1141
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q96AE7

<400>  17

Met Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys 
1               5                   10                  15      


Ser Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala 
            20                  25                  30          


Ala Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly 
        35                  40                  45              


Lys Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His 
    50                  55                  60                  


Asp Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn 
                85                  90                  95      


Glu Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro 
            100                 105                 110         


Asp Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp 
        115                 120                 125             


Gly Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr 
    130                 135                 140                 


Ile Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys 
145                 150                 155                 160 


Thr Lys Ile Leu Glu Leu Pro Tyr Ser Ile His Ala Phe Gln His Leu 
                165                 170                 175     


Arg Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys 
            180                 185                 190         


Glu Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile 
        195                 200                 205             


Asp Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser 
    210                 215                 220                 


Ser Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn 
225                 230                 235                 240 


Glu Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser 
                245                 250                 255     


Ser Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu 
            260                 265                 270         


His Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala 
        275                 280                 285             


Leu Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile 
    290                 295                 300                 


Tyr Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His 
305                 310                 315                 320 


Ala Leu Gln Ala Arg Pro Gly Phe Glu Gln Ala Ile Lys Arg Lys His 
                325                 330                 335     


Ala Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His 
            340                 345                 350         


Arg Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln 
        355                 360                 365             


His Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu 
    370                 375                 380                 


Ile Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met 
385                 390                 395                 400 


Ala Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn 
                405                 410                 415     


Gln Gln His Ser Leu His Cys Gln Trp Asp Gln Pro Val Arg Tyr His 
            420                 425                 430         


Arg Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp 
        435                 440                 445             


Ser Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn 
    450                 455                 460                 


Gln Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser 
465                 470                 475                 480 


Ile Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln 
                485                 490                 495     


His Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg 
            500                 505                 510         


Val Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn 
        515                 520                 525             


Lys Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu 
    530                 535                 540                 


Glu Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser 
545                 550                 555                 560 


His Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu 
                565                 570                 575     


Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg 
            580                 585                 590         


Ile Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe 
        595                 600                 605             


His Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu 
    610                 615                 620                 


Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala 
625                 630                 635                 640 


Cys Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val 
                645                 650                 655     


Pro Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu 
            660                 665                 670         


Asp Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu 
        675                 680                 685             


Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn 
    690                 695                 700                 


Ile Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr 
705                 710                 715                 720 


Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln 
                725                 730                 735     


Phe Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Thr 
            740                 745                 750         


Val Val Glu Glu Ser Asn Gly Ser Asp Glu Met Glu Asn Ser Asp Glu 
        755                 760                 765             


Thr Lys Met Ser Glu Glu Ile Leu Ala Leu Val Asp Glu Phe Gln Gln 
    770                 775                 780                 


Ala Trp Pro Leu Glu Gly Phe Gly Gly Ala Leu Glu Met Lys Gly Arg 
785                 790                 795                 800 


Arg Leu Asp Leu Gln Gly Ile Arg Val Leu Lys Lys Gly Pro Gln Asp 
                805                 810                 815     


Gly Val Ala Arg Ser Ser Cys Tyr Gly Asp Cys Arg Ser Glu Asp Asp 
            820                 825                 830         


Glu Ala Thr Glu Trp Ile Thr Phe Gln Val Lys Arg Val Lys Lys Pro 
        835                 840                 845             


Lys Gly Asp His Lys Lys Thr Pro Gly Lys Lys Val Glu Thr Gly Gln 
    850                 855                 860                 


Ile Glu Asn Gly His Arg Tyr Gln Ala Asn Leu Glu Ile Thr Gly Pro 
865                 870                 875                 880 


Lys Val Ala Ser Pro Gly Pro Gln Gly Lys Lys Arg Asp Tyr Gln Arg 
                885                 890                 895     


Leu Gly Trp Pro Ser Pro Asp Glu Cys Leu Lys Leu Arg Trp Val Glu 
            900                 905                 910         


Leu Thr Ala Ile Val Ser Thr Trp Leu Ala Val Ser Ser Lys Asn Ile 
        915                 920                 925             


Asp Ile Thr Glu His Ile Asp Phe Ala Thr Pro Ile Gln Gln Pro Ala 
    930                 935                 940                 


Met Glu Pro Leu Cys Asn Gly Asn Leu Pro Thr Ser Met His Thr Leu 
945                 950                 955                 960 


Asp His Leu His Gly Val Ser Asn Arg Ala Ser Leu His Tyr Thr Gly 
                965                 970                 975     


Glu Ser Gln Leu Thr Glu Val Leu Gln Asn Leu Gly Lys Asp Gln Tyr 
            980                 985                 990         


Pro Gln Gln Ser Leu Glu Gln Ile  Gly Thr Arg Ile Ala  Lys Val Leu 
        995                 1000                 1005             


Glu Lys  Asn Gln Thr Ser Trp  Val Leu Ser Ser Met  Ala Ala Leu 
    1010                 1015                 1020             


Tyr Trp  Arg Val Lys Gly Gln  Gly Lys Lys Ala Ile  Asp Cys Leu 
    1025                 1030                 1035             


Arg Gln  Ala Leu His Tyr Ala  Pro His Gln Met Lys  Asp Val Pro 
    1040                 1045                 1050             


Leu Ile  Ser Leu Ala Asn Ile  Leu His Asn Ala Lys  Leu Trp Asn 
    1055                 1060                 1065             


Asp Ala  Val Ile Val Ala Thr  Met Ala Val Glu Ile  Ala Pro His 
    1070                 1075                 1080             


Phe Ala  Val Asn His Phe Thr  Leu Gly Asn Val Tyr  Val Ala Met 
    1085                 1090                 1095             


Glu Glu  Phe Glu Lys Ala Leu  Val Trp Tyr Glu Ser  Thr Leu Lys 
    1100                 1105                 1110             


Leu Gln  Pro Glu Phe Val Pro  Ala Lys Asn Arg Ile  Gln Thr Ile 
    1115                 1120                 1125             


Gln Cys  His Leu Met Leu Lys  Lys Gly Arg Arg Ser  Pro 
    1130                 1135                 1140     


<210>  18
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9BZM4

<400>  18

Met Ala Ala Ala Ala Ser Pro Ala Ile Leu Pro Arg Leu Ala Ile Leu 
1               5                   10                  15      


Pro Tyr Leu Leu Phe Asp Trp Ser Gly Thr Gly Arg Ala Asp Ala His 
            20                  25                  30          


Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg His Gly Gln 
        35                  40                  45              


Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn Phe Leu Ser 
    50                  55                  60                  


Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu Met Leu Arg 
                85                  90                  95      


Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr Glu Leu Glu 
            100                 105                 110         


Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg Met Ser Cys 
        115                 120                 125             


Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln Phe Ser Phe 
    130                 135                 140                 


Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr 
145                 150                 155                 160 


Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp Glu Lys Asp 
                165                 170                 175     


Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg Asp Cys Lys 
            180                 185                 190         


Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg Leu Glu Pro 
        195                 200                 205             


Thr Ala Pro Pro Thr Met Ala Pro Gly Leu Ala Gln Pro Lys Ala Ile 
    210                 215                 220                 


Ala Thr Thr Leu Ser Pro Trp Ser Phe Leu Ile Ile Leu Cys Phe Ile 
225                 230                 235                 240 


Leu Pro Gly Ile 
                


<210>  19
<211>  398
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q5T2D3

<400>  19

Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg Ile Asn Asp Asn 
            180                 185                 190         


Ser Glu Ala Pro Ala His Leu Gln Thr Asp Phe Gln Met Leu His Gln 
        195                 200                 205             


Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser 
    210                 215                 220                 


Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys 
225                 230                 235                 240 


Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu 
                245                 250                 255     


Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met 
            260                 265                 270         


Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly 
        275                 280                 285             


Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly 
    290                 295                 300                 


Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn 
305                 310                 315                 320 


Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn 
                325                 330                 335     


Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met 
            340                 345                 350         


Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu 
        355                 360                 365             


Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn 
    370                 375                 380                 


Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 
385                 390                 395             


<210>  20
<211>  1001
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q8IXT5

<400>  20

Met Ala Val Val Ile Arg Leu Leu Gly Leu Pro Phe Ile Ala Gly Pro 
1               5                   10                  15      


Val Asp Ile Arg His Phe Phe Thr Gly Leu Thr Ile Pro Asp Gly Gly 
            20                  25                  30          


Val His Ile Ile Gly Gly Glu Ile Gly Glu Ala Phe Ile Ile Phe Ala 
        35                  40                  45              


Thr Asp Glu Asp Ala Arg Arg Ala Ile Ser Arg Ser Gly Gly Phe Ile 
    50                  55                  60                  


Lys Asp Ser Ser Val Glu Leu Phe Leu Ser Ser Lys Ala Glu Met Gln 
65                  70                  75                  80  


Lys Thr Ile Glu Met Lys Arg Thr Asp Arg Val Gly Arg Gly Arg Pro 
                85                  90                  95      


Gly Ser Gly Thr Ser Gly Val Asp Ser Leu Ser Asn Phe Ile Glu Ser 
            100                 105                 110         


Val Lys Glu Glu Ala Ser Asn Ser Gly Tyr Gly Ser Ser Ile Asn Gln 
        115                 120                 125             


Asp Ala Gly Phe His Thr Asn Gly Thr Gly His Gly Asn Leu Arg Pro 
    130                 135                 140                 


Arg Lys Thr Arg Pro Leu Lys Ala Glu Asn Pro Tyr Leu Phe Leu Arg 
145                 150                 155                 160 


Gly Leu Pro Tyr Leu Val Asn Glu Asp Asp Val Arg Val Phe Phe Ser 
                165                 170                 175     


Gly Leu Cys Val Asp Gly Val Ile Phe Leu Lys His His Asp Gly Arg 
            180                 185                 190         


Asn Asn Gly Asp Ala Ile Val Lys Phe Ala Ser Cys Val Asp Ala Ser 
        195                 200                 205             


Gly Gly Leu Lys Cys His Arg Ser Phe Met Gly Ser Arg Phe Ile Glu 
    210                 215                 220                 


Val Met Gln Gly Ser Glu Gln Gln Trp Ile Glu Phe Gly Gly Asn Ala 
225                 230                 235                 240 


Val Lys Glu Gly Asp Val Leu Arg Arg Ser Glu Glu His Ser Pro Pro 
                245                 250                 255     


Arg Gly Ile Asn Asp Arg His Phe Arg Lys Arg Ser His Ser Lys Ser 
            260                 265                 270         


Pro Arg Arg Thr Arg Ser Arg Ser Pro Leu Gly Phe Tyr Val His Leu 
        275                 280                 285             


Lys Asn Leu Ser Leu Ser Ile Asp Glu Arg Asp Leu Arg Asn Phe Phe 
    290                 295                 300                 


Arg Gly Thr Asp Leu Thr Asp Glu Gln Ile Arg Phe Leu Tyr Lys Asp 
305                 310                 315                 320 


Glu Asn Arg Thr Arg Tyr Ala Phe Val Met Phe Lys Thr Leu Lys Asp 
                325                 330                 335     


Tyr Asn Thr Ala Leu Ser Leu His Lys Thr Val Leu Gln Tyr Arg Pro 
            340                 345                 350         


Val His Ile Asp Pro Ile Ser Arg Lys Gln Met Leu Lys Phe Ile Ala 
        355                 360                 365             


Arg Tyr Glu Lys Lys Arg Ser Gly Ser Leu Glu Arg Asp Arg Pro Gly 
    370                 375                 380                 


His Val Ser Gln Lys Tyr Ser Gln Glu Gly Asn Ser Gly Gln Lys Leu 
385                 390                 395                 400 


Cys Ile Tyr Ile Arg Asn Phe Pro Phe Asp Val Thr Lys Val Glu Val 
                405                 410                 415     


Gln Lys Phe Phe Ala Asp Phe Leu Leu Ala Glu Asp Asp Ile Tyr Leu 
            420                 425                 430         


Leu Tyr Asp Asp Lys Gly Val Gly Leu Gly Glu Ala Leu Val Lys Phe 
        435                 440                 445             


Lys Ser Glu Glu Gln Ala Met Lys Ala Glu Arg Leu Asn Arg Arg Arg 
    450                 455                 460                 


Phe Leu Gly Thr Glu Val Leu Leu Arg Leu Ile Ser Glu Ala Gln Ile 
465                 470                 475                 480 


Gln Glu Phe Gly Val Asn Phe Ser Val Met Ser Ser Glu Lys Met Gln 
                485                 490                 495     


Ala Arg Ser Gln Ser Arg Glu Arg Gly Asp His Ser His Leu Phe Asp 
            500                 505                 510         


Ser Lys Asp Pro Pro Ile Tyr Ser Val Gly Ala Phe Glu Asn Phe Arg 
        515                 520                 525             


His Gln Leu Glu Asp Leu Arg Gln Leu Asp Asn Phe Lys His Pro Gln 
    530                 535                 540                 


Arg Asp Phe Arg Gln Pro Asp Arg His Pro Pro Glu Asp Phe Arg His 
545                 550                 555                 560 


Ser Ser Glu Asp Phe Arg Phe Pro Pro Glu Asp Phe Arg His Ser Pro 
                565                 570                 575     


Glu Asp Phe Arg Arg Pro Arg Glu Glu Asp Phe Arg Arg Pro Ser Glu 
            580                 585                 590         


Glu Asp Phe Arg Arg Pro Trp Glu Glu Asp Phe Arg Arg Pro Pro Glu 
        595                 600                 605             


Asp Asp Phe Arg His Pro Arg Glu Glu Asp Trp Arg Arg Pro Leu Glu 
    610                 615                 620                 


Glu Asp Trp Arg Arg Pro Leu Glu Glu Asp Phe Arg Arg Ser Pro Thr 
625                 630                 635                 640 


Glu Asp Phe Arg Gln Leu Pro Glu Glu Asp Phe Arg Gln Pro Pro Glu 
                645                 650                 655     


Glu Asp Leu Arg Trp Leu Pro Glu Glu Asp Phe Arg Arg Pro Pro Glu 
            660                 665                 670         


Glu Asp Trp Arg Arg Pro Pro Glu Glu Asp Phe Arg Arg Pro Leu Gln 
        675                 680                 685             


Gly Glu Trp Arg Arg Pro Pro Glu Asp Asp Phe Arg Arg Pro Pro Glu 
    690                 695                 700                 


Glu Asp Phe Arg His Ser Pro Glu Glu Asp Phe Arg Gln Ser Pro Gln 
705                 710                 715                 720 


Glu His Phe Arg Arg Pro Pro Gln Glu His Phe Arg Arg Pro Pro Pro 
                725                 730                 735     


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Pro 
            740                 745                 750         


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Pro 
        755                 760                 765             


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Gln 
    770                 775                 780                 


Glu His Phe Arg Arg Pro Pro Gln Glu His Phe Arg Arg Ser Arg Glu 
785                 790                 795                 800 


Glu Asp Phe Arg His Pro Pro Asp Glu Asp Phe Arg Gly Pro Pro Asp 
                805                 810                 815     


Glu Asp Phe Arg His Pro Pro Asp Glu Asp Phe Arg Ser Pro Gln Glu 
            820                 825                 830         


Glu Asp Phe Arg Cys Pro Ser Asp Glu Asp Phe Arg Gln Leu Pro Glu 
        835                 840                 845             


Glu Asp Leu Arg Glu Ala Pro Glu Glu Asp Pro Arg Leu Pro Asp Asn 
    850                 855                 860                 


Phe Arg Pro Pro Gly Glu Asp Phe Arg Ser Pro Pro Asp Asp Phe Arg 
865                 870                 875                 880 


Ser His Arg Pro Phe Val Asn Phe Gly Arg Pro Glu Gly Gly Lys Phe 
                885                 890                 895     


Asp Phe Gly Lys His Asn Met Gly Ser Phe Pro Glu Gly Arg Phe Met 
            900                 905                 910         


Pro Asp Pro Lys Ile Asn Cys Gly Ser Gly Arg Val Thr Pro Ile Lys 
        915                 920                 925             


Ile Met Asn Leu Pro Phe Lys Ala Asn Val Asn Glu Ile Leu Asp Phe 
    930                 935                 940                 


Phe His Gly Tyr Arg Ile Ile Pro Asp Ser Val Ser Ile Gln Tyr Asn 
945                 950                 955                 960 


Glu Gln Gly Leu Pro Thr Gly Glu Ala Ile Val Ala Met Ile Asn Tyr 
                965                 970                 975     


Asn Glu Ala Met Ala Ala Ile Lys Asp Leu Asn Asp Arg Pro Val Gly 
            980                 985                 990         


Pro Arg Lys Val Lys Leu Thr Leu  Leu 
        995                 1000     


<210>  21
<211>  4427
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9P225

<400>  21

Met Ser Ser Lys Ala Glu Lys Lys Gln Arg Leu Ser Gly Arg Gly Ser 
1               5                   10                  15      


Ser Gln Ala Ser Trp Ser Gly Arg Ala Thr Arg Ala Ala Val Ala Thr 
            20                  25                  30          


Gln Glu Gln Gly Asn Ala Pro Ala Val Ser Glu Pro Glu Leu Gln Ala 
        35                  40                  45              


Glu Leu Pro Lys Glu Glu Pro Glu Pro Arg Leu Glu Gly Pro Gln Ala 
    50                  55                  60                  


Gln Ser Glu Glu Ser Val Glu Pro Glu Ala Asp Val Lys Pro Leu Phe 
65                  70                  75                  80  


Leu Ser Arg Ala Ala Leu Thr Gly Leu Ala Asp Ala Val Trp Thr Gln 
                85                  90                  95      


Glu His Asp Ala Ile Leu Glu His Phe Ala Gln Asp Pro Thr Glu Ser 
            100                 105                 110         


Ile Leu Thr Ile Phe Ile Asp Pro Cys Phe Gly Leu Lys Leu Glu Leu 
        115                 120                 125             


Gly Met Pro Val Gln Thr Gln Asn Gln Leu Val Tyr Phe Ile Arg Gln 
    130                 135                 140                 


Ala Pro Val Pro Ile Thr Trp Glu Asn Phe Glu Ala Thr Val Gln Phe 
145                 150                 155                 160 


Gly Thr Val Arg Gly Pro Tyr Ile Pro Ala Leu Leu Arg Leu Leu Gly 
                165                 170                 175     


Gly Val Phe Ala Pro Gln Ile Phe Ala Asn Thr Gly Trp Pro Glu Ser 
            180                 185                 190         


Ile Arg Asn His Phe Ala Ser His Leu His Lys Phe Leu Ala Cys Leu 
        195                 200                 205             


Thr Asp Thr Arg Tyr Lys Leu Glu Gly His Thr Val Leu Tyr Ile Pro 
    210                 215                 220                 


Ala Glu Ala Met Asn Met Lys Pro Glu Met Val Ile Lys Asp Lys Glu 
225                 230                 235                 240 


Leu Val Gln Arg Leu Glu Thr Ser Met Ile His Trp Thr Arg Gln Ile 
                245                 250                 255     


Lys Glu Met Leu Ser Ala Gln Glu Thr Val Glu Thr Gly Glu Asn Leu 
            260                 265                 270         


Gly Pro Leu Glu Glu Ile Glu Phe Trp Arg Asn Arg Cys Met Asp Leu 
        275                 280                 285             


Ser Gly Ile Ser Lys Gln Leu Val Lys Lys Gly Val Lys His Val Glu 
    290                 295                 300                 


Ser Ile Leu His Leu Ala Lys Ser Ser Tyr Leu Ala Pro Phe Met Lys 
305                 310                 315                 320 


Leu Ala Gln Gln Ile Gln Asp Gly Ser Arg Gln Ala Gln Ser Asn Leu 
                325                 330                 335     


Thr Phe Leu Ser Ile Leu Lys Glu Pro Tyr Gln Glu Leu Ala Phe Met 
            340                 345                 350         


Lys Pro Lys Asp Ile Ser Ser Lys Leu Pro Lys Leu Ile Ser Leu Ile 
        355                 360                 365             


Arg Ile Ile Trp Val Asn Ser Pro His Tyr Asn Thr Arg Glu Arg Leu 
    370                 375                 380                 


Thr Ser Leu Phe Arg Lys Val Cys Asp Cys Gln Tyr His Phe Ala Arg 
385                 390                 395                 400 


Trp Glu Asp Gly Lys Gln Gly Pro Leu Pro Cys Phe Phe Gly Ala Gln 
                405                 410                 415     


Gly Pro Gln Ile Thr Arg Asn Leu Leu Glu Ile Glu Asp Ile Phe His 
            420                 425                 430         


Lys Asn Leu His Thr Leu Arg Ala Val Arg Gly Gly Ile Leu Asp Val 
        435                 440                 445             


Lys Asn Thr Cys Trp His Glu Asp Tyr Asn Lys Phe Arg Ala Gly Ile 
    450                 455                 460                 


Lys Asp Leu Glu Val Met Thr Gln Asn Leu Ile Thr Ser Ala Phe Glu 
465                 470                 475                 480 


Leu Val Arg Asp Val Pro His Gly Val Leu Leu Leu Asp Thr Phe His 
                485                 490                 495     


Arg Leu Ala Ser Arg Glu Ala Ile Lys Arg Thr Tyr Asp Lys Lys Ala 
            500                 505                 510         


Val Asp Leu Tyr Met Leu Phe Asn Ser Glu Leu Ala Leu Val Asn Arg 
        515                 520                 525             


Glu Arg Asn Lys Lys Trp Pro Asp Leu Glu Pro Tyr Val Ala Gln Tyr 
    530                 535                 540                 


Ser Gly Lys Ala Arg Trp Val His Ile Leu Arg Arg Arg Ile Asp Arg 
545                 550                 555                 560 


Val Met Thr Cys Leu Ala Gly Ala His Phe Leu Pro Arg Ile Gly Thr 
                565                 570                 575     


Gly Lys Glu Ser Val His Thr Tyr Gln Gln Met Val Gln Ala Ile Asp 
            580                 585                 590         


Glu Leu Val Arg Lys Thr Phe Gln Glu Trp Thr Ser Ser Leu Asp Lys 
        595                 600                 605             


Asp Cys Ile Arg Arg Leu Asp Thr Pro Leu Leu Arg Ile Ser Gln Glu 
    610                 615                 620                 


Lys Ala Gly Met Leu Asp Val Asn Phe Asp Lys Ser Leu Leu Ile Leu 
625                 630                 635                 640 


Phe Ala Glu Ile Asp Tyr Trp Glu Arg Leu Leu Phe Glu Thr Pro His 
                645                 650                 655     


Tyr Val Val Asn Val Ala Glu Arg Ala Glu Asp Leu Arg Ile Leu Arg 
            660                 665                 670         


Glu Asn Leu Leu Leu Val Ala Arg Asp Tyr Asn Arg Ile Ile Ala Met 
        675                 680                 685             


Leu Ser Pro Asp Glu Gln Ala Leu Phe Lys Glu Arg Ile Arg Leu Leu 
    690                 695                 700                 


Asp Lys Lys Ile His Pro Gly Leu Lys Lys Leu His Trp Ala Leu Lys 
705                 710                 715                 720 


Gly Ala Ser Ala Phe Phe Ile Thr Glu Cys Arg Ile His Ala Ser Lys 
                725                 730                 735     


Val Gln Met Ile Val Asn Glu Phe Lys Ala Ser Thr Leu Thr Ile Gly 
            740                 745                 750         


Trp Arg Ala Gln Glu Met Ser Glu Lys Leu Leu Val Arg Ile Ser Gly 
        755                 760                 765             


Lys Arg Val Tyr Arg Asp Leu Glu Phe Glu Glu Asp Gln Arg Glu His 
    770                 775                 780                 


Arg Ala Ala Val Gln Gln Lys Leu Met Asn Leu His Gln Asp Val Val 
785                 790                 795                 800 


Thr Ile Met Thr Asn Ser Tyr Glu Val Phe Lys Asn Asp Gly Pro Glu 
                805                 810                 815     


Ile Gln Gln Gln Trp Met Leu Tyr Met Ile Arg Leu Asp Arg Met Met 
            820                 825                 830         


Glu Asp Ala Leu Arg Leu Asn Val Lys Trp Ser Leu Leu Glu Leu Ser 
        835                 840                 845             


Lys Ala Ile Asn Gly Asp Gly Lys Thr Ser Pro Asn Pro Leu Phe Gln 
    850                 855                 860                 


Val Leu Val Ile Leu Lys Asn Asp Leu Gln Gly Ser Val Ala Gln Val 
865                 870                 875                 880 


Glu Phe Ser Pro Thr Leu Gln Thr Leu Ala Gly Val Val Asn Asp Ile 
                885                 890                 895     


Gly Asn His Leu Phe Ser Thr Ile Ser Val Phe Cys His Leu Pro Asp 
            900                 905                 910         


Ile Leu Thr Lys Arg Lys Leu His Arg Glu Pro Ile Gln Thr Val Val 
        915                 920                 925             


Glu Gln Asp Glu Asp Ile Lys Lys Ile Gln Thr Gln Ile Ser Ser Gly 
    930                 935                 940                 


Met Thr Asn Asn Ala Ser Leu Leu Gln Asn Tyr Leu Lys Thr Trp Asp 
945                 950                 955                 960 


Met Tyr Arg Glu Ile Trp Glu Ile Asn Lys Asp Ser Phe Ile His Arg 
                965                 970                 975     


Tyr Gln Arg Leu Asn Pro Pro Val Ser Ser Phe Val Ala Asp Ile Ala 
            980                 985                 990         


Arg Tyr Thr Glu Val Ala Asn Asn  Val Gln Lys Glu Glu  Thr Val Thr 
        995                 1000                 1005             


Asn Ile  Gln Phe Val Leu Leu  Asp Cys Ser His Leu  Lys Phe Ser 
    1010                 1015                 1020             


Leu Val  Gln His Cys Asn Glu  Trp Gln Asn Lys Phe  Ala Thr Leu 
    1025                 1030                 1035             


Leu Arg  Glu Met Ala Ala Gly  Arg Leu Leu Glu Leu  His Thr Tyr 
    1040                 1045                 1050             


Leu Lys  Glu Asn Ala Glu Lys  Ile Ser Arg Pro Pro  Gln Thr Leu 
    1055                 1060                 1065             


Glu Glu  Leu Gly Val Ser Leu  Gln Leu Val Asp Ala  Leu Lys His 
    1070                 1075                 1080             


Asp Leu  Ala Asn Val Glu Thr  Gln Ile Pro Pro Ile  His Glu Gln 
    1085                 1090                 1095             


Phe Ala  Ile Leu Glu Lys Tyr  Glu Val Pro Val Glu  Asp Ser Val 
    1100                 1105                 1110             


Leu Glu  Met Leu Asp Ser Leu  Asn Gly Glu Trp Val  Val Phe Gln 
    1115                 1120                 1125             


Gln Thr  Leu Leu Asp Ser Lys  Gln Met Leu Lys Lys  His Lys Glu 
    1130                 1135                 1140             


Lys Phe  Lys Thr Gly Leu Ile  His Ser Ala Asp Asp  Phe Lys Lys 
    1145                 1150                 1155             


Lys Ala  His Thr Leu Leu Glu  Asp Phe Glu Phe Lys  Gly His Phe 
    1160                 1165                 1170             


Thr Ser  Asn Val Gly Tyr Met  Ser Ala Leu Asp Gln  Ile Thr Gln 
    1175                 1180                 1185             


Val Arg  Ala Met Leu Met Ala  Met Arg Glu Glu Glu  Asn Ser Leu 
    1190                 1195                 1200             


Arg Ala  Asn Leu Gly Ile Phe  Lys Ile Glu Gln Pro  Pro Ser Lys 
    1205                 1210                 1215             


Asp Leu  Gln Asn Leu Glu Lys  Glu Leu Asp Ala Leu  Gln Gln Ile 
    1220                 1225                 1230             


Trp Glu  Ile Ala Arg Asp Trp  Glu Glu Asn Trp Asn  Glu Trp Lys 
    1235                 1240                 1245             


Thr Gly  Arg Phe Leu Ile Leu  Gln Thr Glu Thr Met  Glu Thr Thr 
    1250                 1255                 1260             


Ala His  Gly Leu Phe Arg Arg  Leu Thr Lys Leu Ala  Lys Glu Tyr 
    1265                 1270                 1275             


Lys Asp  Arg Asn Trp Glu Ile  Ile Glu Thr Thr Arg  Ser Lys Ile 
    1280                 1285                 1290             


Glu Gln  Phe Lys Arg Thr Met  Pro Leu Ile Ser Asp  Leu Arg Asn 
    1295                 1300                 1305             


Pro Ala  Leu Arg Glu Arg His  Trp Asp Gln Val Arg  Asp Glu Ile 
    1310                 1315                 1320             


Gln Arg  Glu Phe Asp Gln Glu  Ser Glu Ser Phe Thr  Leu Glu Gln 
    1325                 1330                 1335             


Ile Val  Glu Leu Gly Met Asp  Gln His Val Glu Lys  Ile Gly Glu 
    1340                 1345                 1350             


Ile Ser  Ala Ser Ala Thr Lys  Glu Leu Ala Ile Glu  Val Ala Leu 
    1355                 1360                 1365             


Gln Asn  Ile Ala Lys Thr Trp  Asp Val Thr Gln Leu  Asp Ile Val 
    1370                 1375                 1380             


Pro Tyr  Lys Asp Lys Gly His  His Arg Leu Arg Gly  Thr Glu Glu 
    1385                 1390                 1395             


Val Phe  Gln Ala Leu Glu Asp  Asn Gln Val Ala Leu  Ser Thr Met 
    1400                 1405                 1410             


Lys Ala  Ser Arg Phe Val Lys  Ala Phe Glu Lys Asp  Val Asp His 
    1415                 1420                 1425             


Trp Glu  Arg Cys Leu Ser Leu  Ile Leu Glu Val Ile  Glu Met Ile 
    1430                 1435                 1440             


Leu Thr  Val Gln Arg Gln Trp  Met Tyr Leu Glu Asn  Ile Phe Leu 
    1445                 1450                 1455             


Gly Glu  Asp Ile Arg Lys Gln  Leu Pro Asn Glu Ser  Thr Leu Phe 
    1460                 1465                 1470             


Asp Gln  Val Asn Ser Asn Trp  Lys Ala Ile Met Asp  Arg Met Asn 
    1475                 1480                 1485             


Lys Asp  Asn Asn Ala Leu Arg  Ser Thr His His Pro  Gly Leu Leu 
    1490                 1495                 1500             


Asp Thr  Leu Ile Glu Met Asn  Thr Ile Leu Glu Asp  Ile Gln Lys 
    1505                 1510                 1515             


Ser Leu  Asp Met Tyr Leu Glu  Thr Lys Arg His Ile  Phe Pro Arg 
    1520                 1525                 1530             


Phe Tyr  Phe Leu Ser Asn Asp  Asp Leu Leu Glu Ile  Leu Gly Gln 
    1535                 1540                 1545             


Ser Arg  Asn Pro Glu Ala Val  Gln Pro His Leu Lys  Lys Cys Phe 
    1550                 1555                 1560             


Asp Asn  Ile Lys Leu Leu Arg  Ile Gln Lys Val Gly  Gly Pro Ser 
    1565                 1570                 1575             


Ser Lys  Trp Glu Ala Val Gly  Met Phe Ser Gly Asp  Gly Glu Tyr 
    1580                 1585                 1590             


Ile Asp  Phe Leu His Ser Val  Phe Leu Glu Gly Pro  Val Glu Ser 
    1595                 1600                 1605             


Trp Leu  Gly Asp Val Glu Gln  Thr Met Arg Val Thr  Leu Arg Asp 
    1610                 1615                 1620             


Leu Leu  Arg Asn Cys His Leu  Ala Leu Arg Lys Phe  Leu Asn Lys 
    1625                 1630                 1635             


Arg Asp  Lys Trp Val Lys Glu  Trp Ala Gly Gln Val  Val Ile Thr 
    1640                 1645                 1650             


Ala Ser  Gln Ile Gln Trp Thr  Ala Asp Val Thr Lys  Cys Leu Leu 
    1655                 1660                 1665             


Thr Ala  Lys Glu Arg Ala Asp  Lys Lys Ile Leu Lys  Val Met Lys 
    1670                 1675                 1680             


Lys Asn  Gln Val Ser Ile Leu  Asn Lys Tyr Ser Glu  Ala Ile Arg 
    1685                 1690                 1695             


Gly Asn  Leu Thr Lys Ile Met  Arg Leu Lys Ile Val  Ala Leu Val 
    1700                 1705                 1710             


Thr Ile  Glu Ile His Ala Arg  Asp Val Leu Glu Lys  Leu Tyr Lys 
    1715                 1720                 1725             


Ser Gly  Leu Met Asp Val Asn  Ser Phe Asp Trp Leu  Ser Gln Leu 
    1730                 1735                 1740             


Arg Phe  Tyr Trp Glu Lys Asp  Leu Asp Asp Cys Val  Ile Arg Gln 
    1745                 1750                 1755             


Thr Asn  Thr Gln Phe Gln Tyr  Asn Tyr Glu Tyr Leu  Gly Asn Ser 
    1760                 1765                 1770             


Gly Arg  Leu Val Ile Thr Pro  Leu Thr Asp Arg Cys  Tyr Met Thr 
    1775                 1780                 1785             


Leu Thr  Thr Ala Leu His Leu  His Arg Gly Gly Ser  Pro Lys Gly 
    1790                 1795                 1800             


Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Val Lys Asp  Leu Gly Lys 
    1805                 1810                 1815             


Ala Leu  Gly Ile Tyr Val Ile  Val Val Asn Cys Ser  Glu Gly Leu 
    1820                 1825                 1830             


Asp Tyr  Lys Ser Met Gly Arg  Met Tyr Ser Gly Leu  Ala Gln Thr 
    1835                 1840                 1845             


Gly Ala  Trp Gly Cys Phe Asp  Glu Phe Asn Arg Ile  Asn Ile Glu 
    1850                 1855                 1860             


Val Leu  Ser Val Val Ala His  Gln Ile Leu Cys Ile  Leu Ser Ala 
    1865                 1870                 1875             


Leu Ala  Ala Gly Leu Thr His  Phe His Phe Asp Gly  Phe Glu Ile 
    1880                 1885                 1890             


Asn Leu  Val Trp Ser Cys Gly  Ile Phe Ile Thr Met  Asn Pro Gly 
    1895                 1900                 1905             


Tyr Ala  Gly Arg Thr Glu Leu  Pro Glu Asn Leu Lys  Ser Met Phe 
    1910                 1915                 1920             


Arg Pro  Ile Ala Met Val Val  Pro Asp Ser Thr Leu  Ile Ala Glu 
    1925                 1930                 1935             


Ile Ile  Leu Phe Gly Glu Gly  Phe Gly Asn Cys Lys  Ile Leu Ala 
    1940                 1945                 1950             


Lys Lys  Val Tyr Thr Leu Tyr  Ser Leu Ala Val Gln  Gln Leu Ser 
    1955                 1960                 1965             


Arg Gln  Asp His Tyr Asp Phe  Gly Leu Arg Ala Leu  Thr Ser Leu 
    1970                 1975                 1980             


Leu Arg  Tyr Ala Gly Lys Lys  Arg Arg Leu Gln Pro  Asp Leu Thr 
    1985                 1990                 1995             


Asp Glu  Glu Val Leu Leu Leu  Ser Met Arg Asp Met  Asn Ile Ala 
    2000                 2005                 2010             


Lys Leu  Thr Ser Val Asp Ala  Pro Leu Phe Asn Ala  Ile Val Gln 
    2015                 2020                 2025             


Asp Leu  Phe Pro Asn Ile Glu  Leu Pro Val Ile Asp  Tyr Gly Lys 
    2030                 2035                 2040             


Leu Arg  Glu Thr Val Glu Gln  Glu Ile Arg Asp Met  Gly Leu Gln 
    2045                 2050                 2055             


Ser Thr  Pro Phe Thr Leu Thr  Lys Val Phe Gln Leu  Tyr Glu Thr 
    2060                 2065                 2070             


Lys Asn  Ser Arg His Ser Thr  Met Ile Val Gly Cys  Thr Gly Ser 
    2075                 2080                 2085             


Gly Lys  Thr Ala Ser Trp Arg  Ile Leu Gln Ala Ser  Leu Ser Ser 
    2090                 2095                 2100             


Leu Cys  Arg Ala Gly Asp Pro  Asn Phe Asn Ile Val  Arg Glu Phe 
    2105                 2110                 2115             


Pro Leu  Asn Pro Lys Ala Leu  Ser Leu Gly Glu Leu  Tyr Gly Glu 
    2120                 2125                 2130             


Tyr Asp  Leu Ser Thr Asn Glu  Trp Thr Asp Gly Ile  Leu Ser Ser 
    2135                 2140                 2145             


Val Met  Arg Thr Ala Cys Ala  Asp Glu Lys Pro Asp  Glu Lys Trp 
    2150                 2155                 2160             


Ile Leu  Phe Asp Gly Pro Val  Asp Thr Leu Trp Ile  Glu Asn Met 
    2165                 2170                 2175             


Asn Ser  Val Met Asp Asp Asn  Lys Val Leu Thr Leu  Ile Asn Gly 
    2180                 2185                 2190             


Glu Arg  Ile Ala Met Pro Glu  Gln Val Ser Leu Leu  Phe Glu Val 
    2195                 2200                 2205             


Glu Asp  Leu Ala Met Ala Ser  Pro Ala Thr Val Ser  Arg Cys Gly 
    2210                 2215                 2220             


Met Val  Tyr Thr Asp Tyr Ala  Asp Leu Gly Trp Lys  Pro Tyr Val 
    2225                 2230                 2235             


Gln Ser  Trp Leu Glu Lys Arg  Pro Lys Ala Glu Val  Glu Pro Leu 
    2240                 2245                 2250             


Gln Arg  Met Phe Glu Lys Leu  Ile Asn Lys Met Leu  Ala Phe Lys 
    2255                 2260                 2265             


Lys Asp  Asn Cys Lys Glu Leu  Val Pro Leu Pro Glu  Tyr Ser Gly 
    2270                 2275                 2280             


Ile Thr  Ser Leu Cys Lys Leu  Tyr Ser Ala Leu Ala  Thr Pro Glu 
    2285                 2290                 2295             


Asn Gly  Val Asn Pro Ala Asp  Gly Glu Asn Tyr Val  Thr Met Val 
    2300                 2305                 2310             


Glu Met  Thr Phe Val Phe Ser  Met Ile Trp Ser Val  Cys Ala Ser 
    2315                 2320                 2325             


Val Asp  Glu Glu Gly Arg Lys  Arg Ile Asp Ser Tyr  Leu Arg Glu 
    2330                 2335                 2340             


Ile Glu  Gly Ser Phe Pro Asn  Lys Asp Thr Val Tyr  Glu Tyr Phe 
    2345                 2350                 2355             


Val Asp  Pro Lys Ile Arg Ser  Trp Thr Ser Phe Glu  Asp Lys Leu 
    2360                 2365                 2370             


Pro Lys  Ser Trp Arg Tyr Pro  Pro Asn Ala Pro Phe  Tyr Lys Ile 
    2375                 2380                 2385             


Met Val  Pro Thr Val Asp Thr  Val Arg Tyr Asn Tyr  Leu Val Ser 
    2390                 2395                 2400             


Ser Leu  Val Ala Asn Gln Asn  Pro Ile Leu Leu Val  Gly Pro Val 
    2405                 2410                 2415             


Gly Thr  Gly Lys Thr Ser Ile  Ala Gln Ser Val Leu  Gln Ser Leu 
    2420                 2425                 2430             


Pro Ser  Ser Gln Trp Ser Val  Leu Val Val Asn Met  Ser Ala Gln 
    2435                 2440                 2445             


Thr Thr  Ser Asn Asn Val Gln  Ser Ile Ile Glu Ser  Arg Val Glu 
    2450                 2455                 2460             


Lys Arg  Thr Lys Gly Val Tyr  Val Pro Phe Gly Gly  Lys Ser Met 
    2465                 2470                 2475             


Ile Thr  Phe Met Asp Asp Leu  Asn Met Pro Ala Lys  Asp Met Phe 
    2480                 2485                 2490             


Gly Ser  Gln Pro Pro Leu Glu  Leu Ile Arg Leu Trp  Ile Asp Tyr 
    2495                 2500                 2505             


Gly Phe  Trp Tyr Asp Arg Thr  Lys Gln Thr Ile Lys  Tyr Ile Arg 
    2510                 2515                 2520             


Glu Met  Phe Leu Met Ala Ala  Met Gly Pro Pro Gly  Gly Gly Arg 
    2525                 2530                 2535             


Thr Val  Ile Ser Pro Arg Leu  Arg Ser Arg Phe Asn  Ile Ile Asn 
    2540                 2545                 2550             


Met Thr  Phe Pro Thr Lys Ser  Gln Ile Ile Arg Ile  Phe Gly Thr 
    2555                 2560                 2565             


Met Ile  Asn Gln Lys Leu Gln  Asp Phe Glu Glu Glu  Val Lys Pro 
    2570                 2575                 2580             


Ile Gly  Asn Val Val Thr Glu  Ala Thr Leu Asp Met  Tyr Asn Thr 
    2585                 2590                 2595             


Val Val  Gln Arg Phe Leu Pro  Thr Pro Thr Lys Met  His Tyr Leu 
    2600                 2605                 2610             


Phe Asn  Leu Arg Asp Ile Ser  Lys Val Phe Gln Gly  Met Leu Arg 
    2615                 2620                 2625             


Ala Asn  Lys Asp Phe His Asp  Thr Lys Ser Ser Ile  Thr Arg Leu 
    2630                 2635                 2640             


Trp Ile  His Glu Cys Phe Arg  Val Phe Ser Asp Arg  Leu Val Asp 
    2645                 2650                 2655             


Ala Ala  Asp Thr Glu Ala Phe  Met Gly Ile Ile Ser  Asp Lys Leu 
    2660                 2665                 2670             


Gly Ser  Phe Phe Asp Leu Thr  Phe His His Leu Cys  Pro Ser Lys 
    2675                 2680                 2685             


Arg Pro  Pro Ile Phe Gly Asp  Phe Leu Lys Glu Pro  Lys Val Tyr 
    2690                 2695                 2700             


Glu Asp  Leu Thr Asp Leu Thr  Val Leu Lys Thr Val  Met Glu Thr 
    2705                 2710                 2715             


Ala Leu  Asn Glu Tyr Asn Leu  Ser Pro Ser Val Val  Pro Met Gln 
    2720                 2725                 2730             


Leu Val  Leu Phe Arg Glu Ala  Ile Glu His Ile Thr  Arg Ile Val 
    2735                 2740                 2745             


Arg Val  Ile Gly Gln Pro Arg  Gly Asn Met Leu Leu  Val Gly Ile 
    2750                 2755                 2760             


Gly Gly  Ser Gly Arg Gln Ser  Leu Ala Arg Leu Ala  Ser Ser Ile 
    2765                 2770                 2775             


Cys Asp  Tyr Thr Thr Phe Gln  Ile Glu Val Thr Lys  His Tyr Arg 
    2780                 2785                 2790             


Lys Gln  Glu Phe Arg Asp Asp  Ile Lys Arg Leu Tyr  Arg Gln Ala 
    2795                 2800                 2805             


Gly Val  Glu Leu Lys Thr Thr  Ser Phe Ile Phe Val  Asp Thr Gln 
    2810                 2815                 2820             


Ile Ala  Asp Glu Ser Phe Leu  Glu Asp Ile Asn Asn  Ile Leu Ser 
    2825                 2830                 2835             


Ser Gly  Glu Val Pro Asn Leu  Tyr Lys Pro Asp Glu  Phe Glu Glu 
    2840                 2845                 2850             


Ile Gln  Ser His Ile Ile Asp  Gln Ala Arg Val Glu  Gln Val Pro 
    2855                 2860                 2865             


Glu Ser  Ser Asp Ser Leu Phe  Ala Tyr Leu Ile Glu  Arg Val Gln 
    2870                 2875                 2880             


Asn Asn  Leu His Ile Val Leu  Cys Leu Ser Pro Met  Gly Asp Pro 
    2885                 2890                 2895             


Phe Arg  Asn Trp Ile Arg Gln  Tyr Pro Ala Leu Val  Asn Cys Thr 
    2900                 2905                 2910             


Thr Ile  Asn Trp Phe Ser Glu  Trp Pro Gln Glu Ala  Leu Leu Glu 
    2915                 2920                 2925             


Val Ala  Glu Lys Cys Leu Ile  Gly Val Asp Leu Gly  Thr Gln Glu 
    2930                 2935                 2940             


Asn Ile  His Arg Lys Val Ala  Gln Ile Phe Val Thr  Met His Trp 
    2945                 2950                 2955             


Ser Val  Ala Gln Tyr Ser Gln  Lys Met Leu Leu Glu  Leu Arg Arg 
    2960                 2965                 2970             


His Asn  Tyr Val Thr Pro Thr  Lys Tyr Leu Glu Leu  Leu Ser Gly 
    2975                 2980                 2985             


Tyr Lys  Lys Leu Leu Gly Glu  Lys Arg Gln Glu Leu  Leu Ala Gln 
    2990                 2995                 3000             


Ala Asn  Lys Leu Arg Thr Gly  Leu Phe Lys Ile Asp  Glu Thr Arg 
    3005                 3010                 3015             


Glu Lys  Val Gln Val Met Ser  Leu Glu Leu Glu Asp  Ala Lys Lys 
    3020                 3025                 3030             


Lys Val  Ala Glu Phe Gln Lys  Gln Cys Glu Glu Tyr  Leu Val Ile 
    3035                 3040                 3045             


Ile Val  Gln Gln Lys Arg Glu  Ala Asp Glu Gln Gln  Lys Ala Val 
    3050                 3055                 3060             


Thr Ala  Asn Ser Glu Lys Ile  Ala Val Glu Glu Ile  Lys Cys Gln 
    3065                 3070                 3075             


Ala Leu  Ala Asp Asn Ala Gln  Lys Asp Leu Glu Glu  Ala Leu Pro 
    3080                 3085                 3090             


Ala Leu  Glu Glu Ala Met Arg  Ala Leu Glu Ser Leu  Asn Lys Lys 
    3095                 3100                 3105             


Asp Ile  Gly Glu Ile Lys Ser  Tyr Gly Arg Pro Pro  Ala Gln Val 
    3110                 3115                 3120             


Glu Ile  Val Met Gln Ala Val  Met Ile Leu Arg Gly  Asn Glu Pro 
    3125                 3130                 3135             


Thr Trp  Ala Glu Ala Lys Arg  Gln Leu Gly Glu Gln  Asn Phe Ile 
    3140                 3145                 3150             


Lys Ser  Leu Ile Asn Phe Asp  Lys Asp Asn Ile Ser  Asp Lys Val 
    3155                 3160                 3165             


Leu Lys  Lys Ile Gly Ala Tyr  Cys Ala Gln Pro Asp  Phe Gln Pro 
    3170                 3175                 3180             


Asp Ile  Ile Gly Arg Val Ser  Leu Ala Ala Lys Ser  Leu Cys Met 
    3185                 3190                 3195             


Trp Val  Arg Ala Met Glu Leu  Tyr Gly Arg Leu Tyr  Arg Val Val 
    3200                 3205                 3210             


Glu Pro  Lys Arg Ile Arg Met  Asn Ala Ala Leu Ala  Gln Leu Arg 
    3215                 3220                 3225             


Glu Lys  Gln Ala Ala Leu Ala  Glu Ala Gln Glu Lys  Leu Arg Glu 
    3230                 3235                 3240             


Val Ala  Glu Lys Leu Glu Met  Leu Lys Lys Gln Tyr  Asp Glu Lys 
    3245                 3250                 3255             


Leu Ala  Gln Lys Glu Glu Leu  Arg Lys Lys Ser Glu  Glu Met Glu 
    3260                 3265                 3270             


Leu Lys  Leu Glu Arg Ala Gly  Met Leu Val Ser Gly  Leu Ala Gly 
    3275                 3280                 3285             


Glu Lys  Ala Arg Trp Glu Glu  Thr Val Gln Gly Leu  Glu Glu Asp 
    3290                 3295                 3300             


Leu Gly  Tyr Leu Val Gly Asp  Cys Leu Leu Ala Ala  Ala Phe Leu 
    3305                 3310                 3315             


Ser Tyr  Met Gly Pro Phe Leu  Thr Asn Tyr Arg Asp  Glu Ile Val 
    3320                 3325                 3330             


Asn Gln  Ile Trp Ile Gly Lys  Ile Trp Glu Leu Gln  Val Pro Cys 
    3335                 3340                 3345             


Ser Pro  Ser Phe Ala Ile Asp  Asn Phe Leu Cys Asn  Pro Thr Lys 
    3350                 3355                 3360             


Val Arg  Asp Trp Asn Ile Gln  Gly Leu Pro Ser Asp  Ala Phe Ser 
    3365                 3370                 3375             


Thr Glu  Asn Gly Ile Ile Val  Thr Arg Gly Asn Arg  Trp Ala Leu 
    3380                 3385                 3390             


Met Ile  Asp Pro Gln Ala Gln  Ala Leu Lys Trp Ile  Lys Asn Met 
    3395                 3400                 3405             


Glu Gly  Gly Gln Gly Leu Lys  Ile Ile Asp Leu Gln  Met Ser Asp 
    3410                 3415                 3420             


Tyr Leu  Arg Ile Leu Glu His  Ala Ile His Phe Gly  Tyr Pro Val 
    3425                 3430                 3435             


Leu Leu  Gln Asn Val Gln Glu  Tyr Leu Asp Pro Thr  Leu Asn Pro 
    3440                 3445                 3450             


Met Leu  Asn Lys Ser Val Ala  Arg Ile Gly Gly Arg  Leu Leu Met 
    3455                 3460                 3465             


Arg Ile  Gly Asp Lys Glu Val  Glu Tyr Asn Thr Asn  Phe Arg Phe 
    3470                 3475                 3480             


Tyr Ile  Thr Thr Lys Leu Ser  Asn Pro His Tyr Ser  Pro Glu Thr 
    3485                 3490                 3495             


Ser Ala  Lys Thr Thr Ile Val  Asn Phe Ala Val Lys  Glu Gln Gly 
    3500                 3505                 3510             


Leu Glu  Ala Gln Leu Leu Gly  Ile Val Val Arg Lys  Glu Arg Pro 
    3515                 3520                 3525             


Glu Leu  Glu Glu Gln Lys Asp  Ser Leu Val Ile Asn  Ile Ala Ala 
    3530                 3535                 3540             


Gly Lys  Arg Lys Leu Lys Glu  Leu Glu Asp Glu Ile  Leu Arg Leu 
    3545                 3550                 3555             


Leu Asn  Glu Ala Thr Gly Ser  Leu Leu Asp Asp Val  Gln Leu Val 
    3560                 3565                 3570             


Asn Thr  Leu His Thr Ser Lys  Ile Thr Ala Thr Glu  Val Thr Glu 
    3575                 3580                 3585             


Gln Leu  Glu Thr Ser Glu Thr  Thr Glu Ile Asn Thr  Asp Leu Ala 
    3590                 3595                 3600             


Arg Glu  Ala Tyr Arg Pro Cys  Ala Gln Arg Ala Ser  Ile Leu Phe 
    3605                 3610                 3615             


Phe Val  Leu Asn Asp Met Gly  Cys Ile Asp Pro Met  Tyr Gln Phe 
    3620                 3625                 3630             


Ser Leu  Asp Ala Tyr Ile Ser  Leu Phe Ile Leu Ser  Ile Asp Lys 
    3635                 3640                 3645             


Ser His  Arg Ser Asn Lys Leu  Glu Asp Arg Ile Asp  Tyr Leu Asn 
    3650                 3655                 3660             


Asp Tyr  His Thr Tyr Ala Val  Tyr Arg Tyr Thr Cys  Arg Thr Leu 
    3665                 3670                 3675             


Phe Glu  Arg His Lys Leu Leu  Phe Ser Phe His Met  Cys Ala Lys 
    3680                 3685                 3690             


Ile Leu  Glu Thr Ser Gly Lys  Leu Asn Met Asp Glu  Tyr Asn Phe 
    3695                 3700                 3705             


Phe Leu  Arg Gly Gly Val Val  Leu Asp Arg Glu Gly  Gln Met Asp 
    3710                 3715                 3720             


Asn Pro  Cys Ser Ser Trp Leu  Ala Asp Ala Tyr Trp  Asp Asn Ile 
    3725                 3730                 3735             


Thr Glu  Leu Asp Lys Leu Thr  Asn Phe His Gly Leu  Met Asn Ser 
    3740                 3745                 3750             


Phe Glu  Gln Tyr Pro Arg Asp  Trp His Leu Trp Tyr  Thr Asn Ala 
    3755                 3760                 3765             


Ala Pro  Glu Lys Ala Met Leu  Pro Gly Glu Trp Glu  Asn Ala Cys 
    3770                 3775                 3780             


Asn Glu  Met Gln Arg Met Leu  Ile Val Arg Ser Leu  Arg Gln Asp 
    3785                 3790                 3795             


Arg Val  Ala Phe Cys Val Thr  Ser Phe Ile Ile Thr  Asn Leu Gly 
    3800                 3805                 3810             


Ser Arg  Phe Ile Glu Pro Pro  Val Leu Asn Met Lys  Ser Val Leu 
    3815                 3820                 3825             


Glu Asp  Ser Thr Pro Arg Ser  Pro Leu Val Phe Ile  Leu Ser Pro 
    3830                 3835                 3840             


Gly Val  Asp Pro Thr Ser Ala  Leu Leu Gln Leu Ala  Glu His Met 
    3845                 3850                 3855             


Gly Met  Ala Gln Arg Phe His  Ala Leu Ser Leu Gly  Gln Gly Gln 
    3860                 3865                 3870             


Ala Pro  Ile Ala Ala Arg Leu  Leu Arg Glu Gly Val  Thr Gln Gly 
    3875                 3880                 3885             


His Trp  Val Phe Leu Ala Asn  Cys His Leu Ser Leu  Ser Trp Met 
    3890                 3895                 3900             


Pro Asn  Leu Asp Lys Leu Val  Glu Gln Leu Gln Val  Glu Asp Pro 
    3905                 3910                 3915             


His Pro  Ser Phe Arg Leu Trp  Leu Ser Ser Ile Pro  His Pro Asp 
    3920                 3925                 3930             


Phe Pro  Ile Ser Ile Leu Gln  Val Ser Ile Lys Met  Thr Thr Glu 
    3935                 3940                 3945             


Pro Pro  Lys Gly Leu Lys Ala  Asn Met Thr Arg Leu  Tyr Gln Leu 
    3950                 3955                 3960             


Met Ser  Glu Pro Gln Phe Ser  Arg Cys Ser Lys Pro  Ala Lys Tyr 
    3965                 3970                 3975             


Lys Lys  Leu Leu Phe Ser Leu  Cys Phe Phe His Ser  Val Leu Leu 
    3980                 3985                 3990             


Glu Arg  Lys Lys Phe Leu Gln  Leu Gly Trp Asn Ile  Ile Tyr Gly 
    3995                 4000                 4005             


Phe Asn  Asp Ser Asp Phe Glu  Val Ser Glu Asn Leu  Leu Ser Leu 
    4010                 4015                 4020             


Tyr Leu  Asp Glu Tyr Glu Glu  Thr Pro Trp Asp Ala  Leu Lys Tyr 
    4025                 4030                 4035             


Leu Ile  Ala Gly Ile Asn Tyr  Gly Gly His Val Thr  Asp Asp Trp 
    4040                 4045                 4050             


Asp Arg  Arg Leu Leu Thr Thr  Tyr Ile Asn Asp Tyr  Phe Cys Asp 
    4055                 4060                 4065             


Gln Ser  Leu Ser Thr Pro Phe  His Arg Leu Ser Ala  Leu Glu Thr 
    4070                 4075                 4080             


Tyr Phe  Ile Pro Lys Asp Gly  Ser Leu Ala Ser Tyr  Lys Glu Tyr 
    4085                 4090                 4095             


Ile Ser  Leu Leu Pro Gly Met  Asp Pro Pro Glu Ala  Phe Gly Gln 
    4100                 4105                 4110             


His Pro  Asn Ala Asp Val Ala  Ser Gln Ile Thr Glu  Ala Gln Thr 
    4115                 4120                 4125             


Leu Phe  Asp Thr Leu Leu Ser  Leu Gln Pro Gln Ile  Thr Pro Thr 
    4130                 4135                 4140             


Arg Ala  Gly Gly Gln Thr Arg  Glu Glu Lys Val Leu  Glu Leu Ala 
    4145                 4150                 4155             


Ala Asp  Val Lys Gln Lys Ile  Pro Glu Met Ile Asp  Tyr Glu Gly 
    4160                 4165                 4170             


Thr Gln  Lys Leu Leu Ala Leu  Asp Pro Ser Pro Leu  Asn Val Val 
    4175                 4180                 4185             


Leu Leu  Gln Glu Ile Gln Arg  Tyr Asn Thr Leu Met  Gln Thr Ile 
    4190                 4195                 4200             


Leu Phe  Ser Leu Thr Asp Leu  Glu Lys Gly Ile Gln  Gly Leu Ile 
    4205                 4210                 4215             


Val Met  Ser Thr Ser Leu Glu  Glu Ile Phe Asn Cys  Ile Phe Asp 
    4220                 4225                 4230             


Ala His  Val Pro Pro Leu Trp  Gly Lys Ala Tyr Pro  Ser Gln Lys 
    4235                 4240                 4245             


Pro Leu  Ala Ala Trp Thr Arg  Asp Leu Ala Met Arg  Val Glu Gln 
    4250                 4255                 4260             


Phe Glu  Leu Trp Ala Ser Arg  Ala Arg Pro Pro Val  Ile Phe Trp 
    4265                 4270                 4275             


Leu Ser  Gly Phe Thr Phe Pro  Thr Gly Phe Leu Thr  Ala Val Leu 
    4280                 4285                 4290             


Gln Ser  Ser Ala Arg Gln Asn  Asn Val Ser Val Asp  Ser Leu Ser 
    4295                 4300                 4305             


Trp Glu  Phe Ile Val Ser Thr  Val Asp Asp Ser Asn  Leu Val Tyr 
    4310                 4315                 4320             


Pro Pro  Lys Asp Gly Val Trp  Val Arg Gly Leu Tyr  Leu Glu Gly 
    4325                 4330                 4335             


Ala Gly  Trp Asp Arg Lys Asn  Ser Cys Leu Val Glu  Ala Glu Pro 
    4340                 4345                 4350             


Met Gln  Leu Val Cys Leu Met  Pro Thr Ile His Phe  Arg Pro Ala 
    4355                 4360                 4365             


Glu Ser  Arg Lys Lys Ser Ala  Lys Gly Met Tyr Ser  Cys Pro Cys 
    4370                 4375                 4380             


Tyr Tyr  Tyr Pro Asn Arg Ala  Gly Ser Ser Asp Arg  Ala Ser Phe 
    4385                 4390                 4395             


Val Ile  Gly Ile Asp Leu Arg  Ser Gly Ala Met Thr  Pro Asp His 
    4400                 4405                 4410             


Trp Ile  Lys Arg Gly Thr Ala  Leu Leu Met Ser Leu  Asp Ser 
    4415                 4420                 4425         


<210>  22
<211>  924
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9Y2I9

<400>  22

Met Asp Val Leu Pro Thr Gly Gly Gly Arg Pro Gly Leu Arg Thr Glu 
1               5                   10                  15      


Leu Glu Phe Arg Gly Gly Gly Gly Glu Ala Arg Leu Glu Ser Gln Glu 
            20                  25                  30          


Glu Glu Thr Ile Pro Ala Ala Pro Pro Ala Pro Arg Leu Arg Gly Ala 
        35                  40                  45              


Ala Glu Arg Pro Arg Arg Ser Arg Asp Thr Trp Asp Gly Asp Glu Asp 
    50                  55                  60                  


Thr Glu Pro Gly Glu Ala Cys Gly Gly Arg Thr Ser Arg Thr Ala Ser 
65                  70                  75                  80  


Leu Val Ser Gly Leu Leu Asn Glu Leu Tyr Ser Cys Thr Glu Glu Glu 
                85                  90                  95      


Glu Ala Ala Gly Gly Gly Arg Gly Ala Glu Gly Arg Arg Arg Arg Arg 
            100                 105                 110         


Asp Ser Leu Asp Ser Ser Thr Glu Ala Ser Gly Ser Asp Val Val Leu 
        115                 120                 125             


Gly Gly Arg Ser Gly Ala Gly Asp Ser Arg Val Leu Gln Glu Leu Gln 
    130                 135                 140                 


Glu Arg Pro Ser Gln Arg His Gln Met Leu Tyr Leu Arg Gln Lys Asp 
145                 150                 155                 160 


Ala Asn Glu Leu Lys Thr Ile Leu Arg Glu Leu Lys Tyr Arg Ile Gly 
                165                 170                 175     


Ile Gln Ser Ala Lys Leu Leu Arg His Leu Lys Gln Lys Asp Arg Leu 
            180                 185                 190         


Leu His Lys Val Gln Arg Asn Cys Asp Ile Val Thr Ala Cys Leu Gln 
        195                 200                 205             


Ala Val Ser Gln Lys Arg Arg Val Asp Thr Lys Leu Lys Phe Thr Leu 
    210                 215                 220                 


Glu Pro Ser Leu Gly Gln Asn Gly Phe Gln Gln Trp Tyr Asp Ala Leu 
225                 230                 235                 240 


Lys Ala Val Ala Arg Leu Ser Thr Gly Ile Pro Lys Glu Trp Arg Arg 
                245                 250                 255     


Lys Val Trp Leu Thr Leu Ala Asp His Tyr Leu His Ser Ile Ala Ile 
            260                 265                 270         


Asp Trp Asp Lys Thr Met Arg Phe Thr Phe Asn Glu Arg Ser Asn Pro 
        275                 280                 285             


Asp Asp Asp Ser Met Gly Ile Gln Ile Val Lys Asp Leu His Arg Thr 
    290                 295                 300                 


Gly Cys Ser Ser Tyr Cys Gly Gln Glu Ala Glu Gln Asp Arg Val Val 
305                 310                 315                 320 


Leu Lys Arg Val Leu Leu Ala Tyr Ala Arg Trp Asn Lys Thr Val Gly 
                325                 330                 335     


Tyr Cys Gln Gly Phe Asn Ile Leu Ala Ala Leu Ile Leu Glu Val Met 
            340                 345                 350         


Glu Gly Asn Glu Gly Asp Ala Leu Lys Ile Met Ile Tyr Leu Ile Asp 
        355                 360                 365             


Lys Val Leu Pro Glu Ser Tyr Phe Val Asn Asn Leu Arg Ala Leu Ser 
    370                 375                 380                 


Val Asp Met Ala Val Phe Arg Asp Leu Leu Arg Met Lys Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Gln His Leu Asp Thr Leu Gln Arg Thr Ala Asn Lys Glu Ser 
                405                 410                 415     


Gly Gly Gly Tyr Glu Pro Pro Leu Thr Asn Val Phe Thr Met Gln Trp 
            420                 425                 430         


Phe Leu Thr Leu Phe Ala Thr Cys Leu Pro Asn Gln Thr Val Leu Lys 
        435                 440                 445             


Ile Trp Asp Ser Val Phe Phe Glu Gly Ser Glu Ile Ile Leu Arg Val 
    450                 455                 460                 


Ser Leu Ala Ile Trp Ala Lys Leu Gly Glu Gln Ile Glu Cys Cys Glu 
465                 470                 475                 480 


Thr Ala Asp Glu Phe Tyr Ser Thr Met Gly Arg Leu Thr Gln Glu Met 
                485                 490                 495     


Leu Glu Asn Asp Leu Leu Gln Ser His Glu Leu Met Gln Thr Val Tyr 
            500                 505                 510         


Ser Met Ala Pro Phe Pro Phe Pro Gln Leu Ala Glu Leu Arg Glu Lys 
        515                 520                 525             


Tyr Thr Tyr Asn Ile Thr Pro Phe Pro Ala Thr Val Lys Pro Thr Ser 
    530                 535                 540                 


Val Ser Gly Arg His Ser Lys Ala Arg Asp Ser Asp Glu Glu Asn Asp 
545                 550                 555                 560 


Pro Asp Asp Glu Asp Ala Val Val Asn Ala Val Gly Cys Leu Gly Pro 
                565                 570                 575     


Phe Ser Gly Phe Leu Ala Pro Glu Leu Gln Lys Tyr Gln Lys Gln Ile 
            580                 585                 590         


Lys Glu Pro Asn Glu Glu Gln Ser Leu Arg Ser Asn Asn Ile Ala Glu 
        595                 600                 605             


Leu Ser Pro Gly Ala Ile Asn Ser Cys Arg Ser Glu Tyr His Ala Ala 
    610                 615                 620                 


Phe Asn Ser Met Met Met Glu Arg Met Thr Thr Asp Ile Asn Ala Leu 
625                 630                 635                 640 


Lys Arg Gln Tyr Ser Arg Ile Lys Lys Lys Gln Gln Gln Gln Val His 
                645                 650                 655     


Gln Val Tyr Ile Arg Ala Asp Lys Gly Pro Val Thr Ser Ile Leu Pro 
            660                 665                 670         


Ser Gln Val Asn Ser Ser Pro Val Ile Asn His Leu Leu Leu Gly Lys 
        675                 680                 685             


Lys Met Lys Met Thr Asn Arg Ala Ala Lys Asn Ala Val Ile His Ile 
    690                 695                 700                 


Pro Gly His Thr Gly Gly Lys Ile Ser Pro Val Pro Tyr Glu Asp Leu 
705                 710                 715                 720 


Lys Thr Lys Leu Asn Ser Pro Trp Arg Thr His Ile Arg Val His Lys 
                725                 730                 735     


Lys Asn Met Pro Arg Thr Lys Ser His Pro Gly Cys Gly Asp Thr Val 
            740                 745                 750         


Gly Leu Ile Asp Glu Gln Asn Glu Ala Ser Lys Thr Asn Gly Leu Gly 
        755                 760                 765             


Ala Ala Glu Ala Phe Pro Ser Gly Cys Thr Ala Thr Ala Gly Arg Glu 
    770                 775                 780                 


Gly Ser Ser Pro Glu Gly Ser Thr Arg Arg Thr Ile Glu Gly Gln Ser 
785                 790                 795                 800 


Pro Glu Pro Val Phe Gly Asp Ala Asp Val Asp Val Ser Ala Val Gln 
                805                 810                 815     


Ala Lys Leu Gly Ala Leu Glu Leu Asn Gln Arg Asp Ala Ala Ala Glu 
            820                 825                 830         


Thr Glu Leu Arg Val His Pro Pro Cys Gln Arg His Cys Pro Glu Pro 
        835                 840                 845             


Pro Ser Ala Pro Glu Glu Asn Lys Ala Thr Ser Lys Ala Pro Gln Gly 
    850                 855                 860                 


Ser Asn Ser Lys Thr Pro Ile Phe Ser Pro Phe Pro Ser Val Lys Pro 
865                 870                 875                 880 


Leu Arg Lys Ser Ala Thr Ala Arg Asn Leu Gly Leu Tyr Gly Pro Thr 
                885                 890                 895     


Glu Arg Thr Pro Thr Val His Phe Pro Gln Met Ser Arg Ser Phe Ser 
            900                 905                 910         


Lys Pro Gly Gly Gly Asn Ser Gly Thr Lys Lys Arg 
        915                 920                 


<210>  23
<211>  190
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  P41222 (PTGDS)

<400>  23

Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val 
1               5                   10                  15      


Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro 
            20                  25                  30          


Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu 
        35                  40                  45              


Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met 
    50                  55                  60                  


Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr 
65                  70                  75                  80  


Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu 
                85                  90                  95      


Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp 
            100                 105                 110         


Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr 
        115                 120                 125             


Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg 
    130                 135                 140                 


Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys 
145                 150                 155                 160 


Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr 
                165                 170                 175     


Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr Glu Gln 
            180                 185                 190 


<210>  24
<211>  372
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  P14151 (SELL)

<400>  24

Met Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn 
1               5                   10                  15      


Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala 
            20                  25                  30          


His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met 
        35                  40                  45              


Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu 
    50                  55                  60                  


Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu 
65                  70                  75                  80  


Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly 
                85                  90                  95      


Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu 
            100                 105                 110         


Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys 
        115                 120                 125             


Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp 
    130                 135                 140                 


Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys 
145                 150                 155                 160 


Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn 
                165                 170                 175     


Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln 
            180                 185                 190         


Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met 
        195                 200                 205             


Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala 
    210                 215                 220                 


Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr 
225                 230                 235                 240 


Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val 
                245                 250                 255     


Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys 
            260                 265                 270         


Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile 
        275                 280                 285             


Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu 
    290                 295                 300                 


Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp 
305                 310                 315                 320 


Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile 
                325                 330                 335     


Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile 
            340                 345                 350         


Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met 
        355                 360                 365             


Asn Asp Pro Tyr 
    370         


<210>  25
<211>  518
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q06418 (TYRO3)

<400>  25

Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp Asp Pro Gln Lys 
1               5                   10                  15      


Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val Gly Cys Gly Pro 
            20                  25                  30          


Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg Ala Gly Gln Gln 
        35                  40                  45              


Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val Val Leu Gly Val 
    50                  55                  60                  


Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu Ile Leu Leu Arg 
65                  70                  75                  80  


Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe Asp Ser Val Met 
                85                  90                  95      


Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala Arg Ser Phe Asn 
            100                 105                 110         


Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile 
        115                 120                 125             


Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu Ile Pro Glu Gln 
    130                 135                 140                 


Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu Phe Gly Ser Val 
145                 150                 155                 160 


Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe Val Lys Val Ala 
                165                 170                 175     


Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu 
            180                 185                 190         


Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp His Pro His Val 
        195                 200                 205             


Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu 
    210                 215                 220                 


Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His 
225                 230                 235                 240 


Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro 
                245                 250                 255     


Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala Cys Gly Met Glu 
            260                 265                 270         


Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        275                 280                 285             


Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu 
    290                 295                 300                 


Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser 
305                 310                 315                 320 


Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu 
                325                 330                 335     


Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu 
            340                 345                 350         


Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu 
        355                 360                 365             


Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys Gln Pro Pro Glu 
    370                 375                 380                 


Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp 
385                 390                 395                 400 


Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met Glu Leu Glu Asn 
                405                 410                 415     


Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln Asp Pro Leu Tyr 
            420                 425                 430         


Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly Gly Ser Leu Glu 
        435                 440                 445             


Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly Asp Gly Ser Gly 
    450                 455                 460                 


Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg Tyr Ile Leu Thr 
465                 470                 475                 480 


Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu His Gln Pro Glu 
                485                 490                 495     


Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu 
            500                 505                 510         


Leu Pro His Ser Ser Cys 
        515             


<210>  26
<211>  607
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  P52306 (RAP1GDS1)

<400>  26

Met Asp Asn Leu Ser Asp Thr Leu Lys Lys Leu Lys Ile Thr Ala Val 
1               5                   10                  15      


Asp Lys Thr Glu Asp Ser Leu Glu Gly Cys Leu Asp Cys Leu Leu Gln 
            20                  25                  30          


Ala Leu Ala Gln Asn Asn Thr Glu Thr Ser Glu Lys Ile Gln Ala Ser 
        35                  40                  45              


Gly Ile Leu Gln Leu Phe Ala Ser Leu Leu Thr Pro Gln Ser Ser Cys 
    50                  55                  60                  


Lys Ala Lys Val Ala Asn Ile Ile Ala Glu Val Ala Lys Asn Glu Phe 
65                  70                  75                  80  


Met Arg Ile Pro Cys Val Asp Ala Gly Leu Ile Ser Pro Leu Val Gln 
                85                  90                  95      


Leu Leu Asn Ser Lys Asp Gln Glu Val Leu Leu Gln Thr Gly Arg Ala 
            100                 105                 110         


Leu Gly Asn Ile Cys Tyr Asp Ser His Glu Gly Arg Ser Ala Val Asp 
        115                 120                 125             


Gln Ala Gly Gly Ala Gln Ile Val Ile Asp His Leu Arg Ser Leu Cys 
    130                 135                 140                 


Ser Ile Thr Asp Pro Ala Asn Glu Lys Leu Leu Thr Val Phe Cys Gly 
145                 150                 155                 160 


Met Leu Met Asn Tyr Ser Asn Glu Asn Asp Ser Leu Gln Ala Gln Leu 
                165                 170                 175     


Ile Asn Met Gly Val Ile Pro Thr Leu Val Lys Leu Leu Gly Ile His 
            180                 185                 190         


Cys Gln Asn Ala Ala Leu Thr Glu Met Cys Leu Val Ala Phe Gly Asn 
        195                 200                 205             


Leu Ala Glu Leu Glu Ser Ser Lys Glu Gln Phe Ala Ser Thr Asn Ile 
    210                 215                 220                 


Ala Glu Glu Leu Val Lys Leu Phe Lys Lys Gln Ile Glu His Asp Lys 
225                 230                 235                 240 


Arg Glu Met Ile Phe Glu Val Leu Ala Pro Leu Ala Glu Asn Asp Ala 
                245                 250                 255     


Ile Lys Leu Gln Leu Val Glu Ala Gly Leu Val Glu Cys Leu Leu Glu 
            260                 265                 270         


Ile Val Gln Gln Lys Val Asp Ser Asp Lys Glu Asp Asp Ile Thr Glu 
        275                 280                 285             


Leu Lys Thr Gly Ser Asp Leu Met Val Leu Leu Leu Leu Gly Asp Glu 
    290                 295                 300                 


Ser Met Gln Lys Leu Phe Glu Gly Gly Lys Gly Ser Val Phe Gln Arg 
305                 310                 315                 320 


Val Leu Ser Trp Ile Pro Ser Asn Asn His Gln Leu Gln Leu Ala Gly 
                325                 330                 335     


Ala Leu Ala Ile Ala Asn Phe Ala Arg Asn Asp Ala Asn Cys Ile His 
            340                 345                 350         


Met Val Asp Asn Gly Ile Val Glu Lys Leu Met Asp Leu Leu Asp Arg 
        355                 360                 365             


His Val Glu Asp Gly Asn Val Thr Val Gln His Ala Ala Leu Ser Ala 
    370                 375                 380                 


Leu Arg Asn Leu Ala Ile Pro Val Ile Asn Lys Ala Lys Met Leu Ser 
385                 390                 395                 400 


Ala Gly Val Thr Glu Ala Val Leu Lys Phe Leu Lys Ser Glu Met Pro 
                405                 410                 415     


Pro Val Gln Phe Lys Leu Leu Gly Thr Leu Arg Met Leu Ile Asp Ala 
            420                 425                 430         


Gln Ala Glu Ala Ala Glu Gln Leu Gly Lys Asn Val Lys Leu Val Glu 
        435                 440                 445             


Arg Leu Val Glu Trp Cys Glu Ala Lys Asp His Ala Gly Val Met Gly 
    450                 455                 460                 


Glu Ser Asn Arg Leu Leu Ser Ala Leu Ile Arg His Ser Lys Ser Lys 
465                 470                 475                 480 


Asp Val Ile Lys Thr Ile Val Gln Ser Gly Gly Ile Lys His Leu Val 
                485                 490                 495     


Thr Met Ala Thr Ser Glu His Val Ile Met Gln Asn Glu Ala Leu Val 
            500                 505                 510         


Ala Leu Ala Leu Ile Ala Ala Leu Glu Leu Gly Thr Ala Glu Lys Asp 
        515                 520                 525             


Leu Glu Ser Ala Lys Leu Val Gln Ile Leu His Arg Leu Leu Ala Asp 
    530                 535                 540                 


Glu Arg Ser Ala Pro Glu Ile Lys Tyr Asn Ser Met Val Leu Ile Cys 
545                 550                 555                 560 


Ala Leu Met Gly Ser Glu Cys Leu His Lys Glu Val Gln Asp Leu Ala 
                565                 570                 575     


Phe Leu Asp Val Val Ser Lys Leu Arg Ser His Glu Asn Lys Ser Val 
            580                 585                 590         


Ala Gln Gln Ala Ser Leu Thr Glu Gln Arg Leu Thr Val Glu Ser 
        595                 600                 605         


<210>  27
<211>  322
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Q9Y5Y7 (LYVE1)

<400>  27

Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr 
1               5                   10                  15      


Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile 
            20                  25                  30          


Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala 
        35                  40                  45              


Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala 
65                  70                  75                  80  


Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val 
                85                  90                  95      


Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly 
            100                 105                 110         


Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys 
        115                 120                 125             


Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile 
    130                 135                 140                 


Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr 
145                 150                 155                 160 


Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser 
                165                 170                 175     


Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser 
            180                 185                 190         


Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu 
        195                 200                 205             


Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala 
    210                 215                 220                 


Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu 
225                 230                 235                 240 


Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe 
                245                 250                 255     


Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn 
            260                 265                 270         


Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala 
        275                 280                 285             


Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro 
    290                 295                 300                 


Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala 
305                 310                 315                 320 


Glu Val 
        


