                               SEQUENCE LISTING

<110> IMMUNOMEDICS, INC.
 
<120> ANTI-TROP-2 ANTIBODY-DRUG CONJUGATES AND USES THEREOF

<130> IMM184WO8

<140>
<141>

<150> 14/259,469
<151> 2014-04-23

<150> 14/258,228
<151> 2014-04-22

<150> 14/040,024
<151> 2013-09-27

<160> 96    

<170> PatentIn version 3.5

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala 
1               5                   10      


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gln Gln His Tyr Ile Thr Pro Leu Thr 
1               5                   


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Asn Tyr Gly Met Asn 
1               5   


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210> 7
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 8
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 9
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 10
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 13
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210> 14
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Ser Cys Gly Gly Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys 
1               5                   10                  15      


His Asn Ile Gln Ala Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr 
            20                  25                  30          


Ala Arg Pro Glu Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg 
        35                  40                  45              


Leu Glu Lys Glu Glu Ala Lys 
    50                  55  


<210> 15
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Cys Gly Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser 
1               5                   10                  15      


Asp Val Phe Gln Gln Gly Cys 
            20              


<210> 16
<211> 51
<212> PRT
<213> Homo sapiens

<400> 16
Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Val Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu 
            20                  25                  30          


Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Lys Leu Glu Lys Glu 
        35                  40                  45              


Glu Ala Lys 
    50      


<210> 17
<211> 54
<212> PRT
<213> Homo sapiens

<400> 17
Ser Leu Lys Gly Cys Glu Leu Tyr Val Gln Leu His Gly Ile Gln Gln 
1               5                   10                  15      


Val Leu Lys Asp Cys Ile Val His Leu Cys Ile Ser Lys Pro Glu Arg 
            20                  25                  30          


Pro Met Lys Phe Leu Arg Glu His Phe Glu Lys Leu Glu Lys Glu Glu 
        35                  40                  45              


Asn Arg Gln Ile Leu Ala 
    50                  


<210> 18
<211> 44
<212> PRT
<213> Homo sapiens

<400> 18
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Gly Gln Gln Pro Pro Asp Leu Val Asp Phe Ala Val 
            20                  25                  30          


Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Arg Gln 
        35                  40                  


<210> 19
<211> 44
<212> PRT
<213> Homo sapiens

<400> 19
Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
1               5                   10                  15      


Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
            20                  25                  30          


Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg 
        35                  40                  


<210> 20
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Thr His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 21
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Ser Lys Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 22
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ser Arg Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 23
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Ser His Ile Asn Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 24
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Ser His Ile Gln Ile Pro Pro Ala Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 25
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ser His Ile Gln Ile Pro Pro Gly Leu Ser Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 26
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Asp Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 27
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Asn Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 28
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Ala Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 29
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Ser Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 30
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Asp Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 31
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Lys Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 32
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Asn Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 33
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Asn Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 34
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Glu Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 35
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Asp Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 36
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Leu 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 37
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ile 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 38
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Val 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 39
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Asp Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Asn Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gln Leu Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gln Val Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gln Ile Asp Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 44
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gln Ile Glu Phe Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gln Ile Glu Thr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gln Ile Glu Ser Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gln Ile Glu Tyr Ile Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gln Ile Glu Tyr Leu Ala Arg Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gln Ile Glu Tyr Leu Ala Lys Asn Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Glu Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 52
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Gln Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 53
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Asn Gln 
1               5                   10                  15      


Ala 
    


<210> 54
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Asn 
1               5                   10                  15      


Ala 
    


<210> 55
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Leu 
    


<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ile 
    


<210> 57
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Val 
    


<210> 58
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Tyr Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 59
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gln Ile Glu Tyr Lys Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Gln Ile Glu Tyr His Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 61
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 62
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Pro Leu Glu Tyr Gln Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala Ile 
        


<210> 63
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Leu Leu Ile Glu Thr Ala Ser Ser Leu Val Lys Asn Ala Ile Gln Leu 
1               5                   10                  15      


Ser Ile 
        


<210> 64
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu Gln 
1               5                   10                  15      


Val Lys 
        


<210> 65
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Ala Leu Tyr Gln Phe Ala Asp Arg Phe Ser Glu Leu Val Ile Ser Glu 
1               5                   10                  15      


Ala Leu 
        


<210> 66
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Leu Glu Gln Val Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr 
    


<210> 67
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe 
    


<210> 68
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys 
1               5                   10                  15      


Ala Val 
        


<210> 69
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln Val Val Thr Ala Glu 
1               5                   10                  15      


Ala Val 
        


<210> 70
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gln Ile Lys Gln Ala Ala Phe Gln Leu Ile Ser Gln Val Ile Leu Glu 
1               5                   10                  15      


Ala Thr 
        


<210> 71
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Leu Ala Trp Lys Ile Ala Lys Met Ile Val Ser Asp Val Met Gln Gln 
1               5                   10                  15      


<210> 72
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Gly Ala Tyr 
            20                  


<210> 73
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr Glu 
        


<210> 74
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe Gln Gln Cys 
            20  


<210> 75
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Pro Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 76
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Lys Gly Ala Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala 
1               5                   10                  15      


Val Ile Glu Gln Val Lys Ala Ala Gly 
            20                  25  


<210> 77
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Lys Gly Ala Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Pro Asp Ala 
1               5                   10                  15      


Pro Ile Glu Gln Val Lys Ala Ala Gly 
            20                  25  


<210> 78
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 79
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Pro Glu Asp Ala Glu Leu Val Arg Thr Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 80
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Asp Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 81
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Pro Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 82
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Pro Glu Asn 
1               5                   10                  15      


Ala Pro Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 83
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Glu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 84
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Glu Glu Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln 
1               5                   10                  15      


Ile Ile Ser Gln Val Ile Ser Glu Ala 
            20                  25  


<210> 85
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Leu Val Asp Asp Pro Leu Glu Tyr Gln Ala Gly Leu Leu Val Gln Asn 
1               5                   10                  15      


Ala Ile Gln Gln Ala Ile Ala Glu Gln 
            20                  25  


<210> 86
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Gln Tyr Glu Thr Leu Leu Ile Glu Thr Ala Ser Ser Leu Val Lys Asn 
1               5                   10                  15      


Ala Ile Gln Leu Ser Ile Glu Gln Leu 
            20                  25  


<210> 87
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val Ala Lys Val 
1               5                   10                  15      


Ile Val Ser Met Ser Ile Ala Phe Ala 
            20                  25  


<210> 88
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Asn Thr Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys Met 
1               5                   10                  15      


Ile Val Ser Asp Ile Met Gln Gln Ala 
            20                  25  


<210> 89
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Val Asn Leu Asp Lys Lys Ala Val Leu Ala Glu Lys Ile Val Ala Glu 
1               5                   10                  15      


Ala Ile Glu Lys Ala Glu Arg Glu Leu 
            20                  25  


<210> 90
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Asn Gly Ile Leu Glu Leu Glu Thr Lys Ser Ser Lys Leu Val Gln Asn 
1               5                   10                  15      


Ile Ile Gln Thr Ala Val Asp Gln Phe 
            20                  25  


<210> 91
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Thr Gln Asp Lys Asn Tyr Glu Asp Glu Leu Thr Gln Val Ala Leu Ala 
1               5                   10                  15      


Leu Val Glu Asp Val Ile Asn Tyr Ala 
            20                  25  


<210> 92
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Glu Thr Ser Ala Lys Asp Asn Ile Asn Ile Glu Glu Ala Ala Arg Phe 
1               5                   10                  15      


Leu Val Glu Lys Ile Leu Val Asn His 
            20                  25  


<210> 93
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210> 94
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (2)..(2)
<223> His, Lys or Arg

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Gly or Ala

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Gly or Ala

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asp or Glu

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Ala, Leu, Ile or Val

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Ala, Leu, Ile or Val

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Ala, Leu, Ile or Val

<400> 94
Xaa Xaa Ile Xaa Ile Pro Pro Xaa Leu Xaa Xaa Leu Leu Xaa Xaa Tyr 
1               5                   10                  15      


Xaa Val Xaa Val Leu Xaa Xaa Xaa Pro Pro Xaa Leu Val Xaa Phe Xaa 
            20                  25                  30          


Val Xaa Tyr Phe Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa 
        35                  40                  


<210> 95
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ile, Leu or Val

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Tyr, Phe, Thr or Ser

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Leu, Ile or Val

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Asp or Glu

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asn or Gln

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Leu, Ile or Val

<400> 95
Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Ile Val Xaa Xaa Ala Ile Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 96
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Val, Ile, Leu or Ala

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Val, Ile, Leu or Ala

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Glu or Asp

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Ala, Leu, Ile or Val

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Ala, Leu, Ile or Val 

<400> 96
Xaa His Ile Xaa Ile Pro Pro Gly Leu Xaa Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Xaa Glu Val Leu Arg Xaa Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Xaa Xaa Tyr Phe Xaa Xaa Leu Xaa Glu Xaa Arg Xaa 
        35                  40                  

