                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT 
       HUMAN CLOTTING FACTOR XA PROTEINS

<130>  PC72049

<150>  US 61/881,834
<151>  2013-09-24

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  1

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys 
    130                 135                 140                 


Arg Leu Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln 
145                 150                 155                 160 


Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile 
                165                 170                 175     


Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala 
            180                 185                 190         


Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu 
        195                 200                 205             


Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg 
    210                 215                 220                 


Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys 
225                 230                 235                 240 


Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu 
                245                 250                 255     


Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val 
            260                 265                 270         


Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu 
        275                 280                 285             


Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser 
    290                 295                 300                 


Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr 
305                 310                 315                 320 


Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr 
                325                 330                 335     


Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu 
            340                 345                 350         


Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala 
        355                 360                 365             


Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys 
    370                 375                 380                 


Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
385                 390                 395                 


<210>  2
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  2

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys 
    130                 135                 140                 


Arg 
145 


<210>  3
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  3

Leu Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  4
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified human DNA sequence

<400>  4
atggcgcacg tccgaggctt gcagctgcct ggctgcctgg ccctggctgc cctgtgtagc       60

cttgtgcaca gccagcatgt gttcctggct cctcagcaag cacggtcgct gctccagcgg      120

gtccggcgag ccaattcctt tcttgaagag atgaagaaag gacacctcga aagagagtgc      180

atggaagaga cctgctcata cgaagaggcc cgcgaggtct ttgaggacag cgacaagacg      240

aatgaattct ggaataaata caaagatggc gaccagtgtg agaccagtcc ttgccagaac      300

cagggcaaat gtaaagacgg cctcggggaa tacacctgca cctgtttaga aggattcgaa      360

ggcaaaaact gtgaattatt cacacggaag ctctgcagcc tggacaacgg ggactgtgac      420

cagttctgcc acgaggaaca gaactctgtg gtgtgctcct gcgcccgcgg gtacaccctg      480

gctgacaacg gcaaggcctg cattcccaca gggccctacc cctgtgggaa acagaccctg      540

gaacgcagga agaggcgtaa gcgtctcgtg ggaggccagg aatgcaagga cggggagtgt      600

ccctggcagg ccctgctcat caatgaggaa aacgagggtt tctgtggtgg aactattctg      660

agcgagttct acatcctaac ggcagcccac tgtctctacc aagccaagag attcaaggtg      720

agggtaggtg accggaacac ggagcaggag gagggcggtg aggcggtgca cgaggtggag      780

gtggtcatca agcacaaccg gttcacaaag gagacctatg acttcgacat cgccgtgctc      840

cggctcaaga cccccatcac cttccgcatg aacgtggcgc ctgcctgcct ccccgagcgt      900

gactgggccg agtccacgct gatgacgcag aagacgggga ttgtgagcgg cttcgggcgc      960

acccacgaga agggccggca gtccaccagg ctcaagatgc tggaggtgcc ctacgtggac     1020

cgcaacagct gcaagctgtc cagcagcttc atcatcaccc agaacatgtt ctgtgccggc     1080

tacgacacca agcaggagga tgcctgccag ggggacagcg ggggcccgca cgtcacccgc     1140

ttcaaggaca cctacttcgt gacaggcatc gtcagctggg gagagggctg tgcccgtaag     1200

gggaagtacg ggatctacac caaggtcacc gccttcctca agtggatcga caggtccatg     1260

aaaaccaggg gcttgcccaa ggccaagagc catgccccgg aggtcataac gtcctctcca     1320

ttaaagtga                                                             1329


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACE site

<400>  5

Arg Lys Arg Arg Lys Arg 
1               5       


<210>  6
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  6

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg 
    130                 135                 


<210>  7
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  7

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg 
    130                 135                 140 


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytic fragment

<400>  8

Lys Arg Arg Lys Arg 
1               5   


<210>  9
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  9

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys 
    130                 135                 140     


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytic fragment

<400>  10

Arg Arg Lys Arg 
1               


<210>  11
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  11

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    130                 135                 140         


<210>  12
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  12

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Arg 
    130                 135                 140             


<210>  13
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  13

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys 
    130                 135                 140                 


<210>  14
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  14

Leu Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
                245                 250             


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Ala Asn Ser Phe Leu Xaa Xaa Met Lys Lys 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Leu Val Gly Gly Gln Glu Xaa Lys Asp Gly 
1               5                   10  


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  17

Ala Asn Ser Phe Leu Glu Glu Met Lys 
1               5                   


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  18

Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu 
1               5                   10                  15      


Ala Arg Glu Val Phe Glu Asp Ser Asp Lys 
            20                  25      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  19

Thr Asn Glu Phe Trp Asn Lys 
1               5           


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  20

Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys 
1               5                   10                  15  


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  21

Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly 
1               5                   10                  15      


Lys 
    


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  22

Asn Cys Glu Leu Phe Thr Arg Lys 
1               5               


<210>  23
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  23

Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
1               5                   10                  15      


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
            20                  25                  30          


Asn Gly Lys 
        35  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  24

Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
1               5                   10          


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  25

Gln Thr Leu Glu Arg Arg Lys 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  26

Gln Thr Leu Glu Arg Arg 
1               5       


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  27

Gln Thr Leu Glu Arg 
1               5   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  28

Leu Val Gly Gly Gln Glu Cys Lys 
1               5               


<210>  29
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  29

Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu 
1               5                   10                  15      


Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala 
            20                  25                  30          


Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  30

Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala 
1               5                   10                  15      


Val His Glu Val Glu Val Val Ile Lys 
            20                  25  


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  31

His Asn Arg Phe Thr Lys 
1               5       


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  32

Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys 
1               5                   10              


<210>  33
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  33

Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu 
1               5                   10                  15      


Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys 
            20                  25              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  34

Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys 
1               5                   10              


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  35

Gly Arg Gln Ser Thr Arg Leu Lys 
1               5               


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  36

Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
1               5                   10              


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  37

Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
1               5                   10                  15      


Asp Thr Lys 
            


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  38

Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
1               5                   10                  15      


Phe Lys 
        


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  39

Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala 
1               5                   10                  15      


Arg Lys 
        


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  40

Tyr Gly Ile Tyr Thr Lys 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  41

Val Thr Ala Phe Leu Lys 
1               5       


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  42

Trp Ile Asp Arg Ser Met Lys 
1               5           


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  43

Thr Arg Gly Leu Pro Lys 
1               5       


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  44

Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
1               5                   10              


<210>  45
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  45

Leu Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys 
225                 230                 235                 


<210>  46
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified human protein sequence

<400>  46

Leu Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys 
    


