                         SEQUENCE LISTING

<110>  INSERM
 
<120>  A DYRK1A POLYPEPTIDE FOR USE IN PREVENTING OR TREATING METABOLIC 
       DISORDERS

<130>  12387RACHDI

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  763
<212>  PRT
<213>  homo sapiens

<400>  1

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Arg Gln 
545                 550                 555                 560 


Gln Phe Pro Ala Pro Leu Gly Trp Ser Gly Thr Glu Ala Pro Thr Gln 
                565                 570                 575     


Val Thr Val Glu Thr His Pro Val Gln Glu Thr Thr Phe His Val Ala 
            580                 585                 590         


Pro Gln Gln Asn Ala Leu His His His His Gly Asn Ser Ser His His 
        595                 600                 605             


His His His His His His His His His His His Gly Gln Gln Ala Leu 
    610                 615                 620                 


Gly Asn Arg Thr Arg Pro Arg Val Tyr Asn Ser Pro Thr Asn Ser Ser 
625                 630                 635                 640 


Ser Thr Gln Asp Ser Met Glu Val Gly His Ser His His Ser Met Thr 
                645                 650                 655     


Ser Leu Ser Ser Ser Thr Thr Ser Ser Ser Thr Ser Ser Ser Ser Thr 
            660                 665                 670         


Gly Asn Gln Gly Asn Gln Ala Tyr Gln Asn Arg Pro Val Ala Ala Asn 
        675                 680                 685             


Thr Leu Asp Phe Gly Gln Asn Gly Ala Met Asp Val Asn Leu Thr Val 
    690                 695                 700                 


Tyr Ser Asn Pro Arg Gln Glu Thr Gly Ile Ala Gly His Pro Thr Tyr 
705                 710                 715                 720 


Gln Phe Ser Ala Asn Thr Gly Pro Ala His Tyr Met Thr Glu Gly His 
                725                 730                 735     


Leu Thr Met Arg Gln Gly Ala Asp Arg Glu Glu Ser Pro Met Thr Gly 
            740                 745                 750         


Val Cys Val Gln Gln Ser Pro Val Ala Ser Ser 
        755                 760             


<210>  2
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  HIV transactivator of transcription (TAT) peptide

<400>  2

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Penetratin or Antennapedia PTD

<400>  3

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  4
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  SynB1

<400>  4

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  5
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Transportan

<400>  5

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  6
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Pep-1

<400>  6

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  7
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  MAP

<400>  7

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  8
cccaguguuu agacuaucug uuc                                             23


<210>  9
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  9
uuagggcccu ggcuccaucu cc                                              22


