                         SEQUENCE LISTING

<110>  MEDICENNA THERAPEUTICS PTE LTD
       MERCHANT, Fahar
 
<120>  INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF

<130>  PAT 102517AW-90

<150>  US 61/881,930
<151>  2013-09-24

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 sequence including an additional methionine at the 
       N-terminus

<400>  1

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  2
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 sequence including an additional methionine at the 
       N-terminus

<400>  2

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  3
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-4 sequence

<400>  3

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  4
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "RGA" variant IL-4

<400>  4

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  5
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "KFR" variant IL-4

<400>  5

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  6
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "KF" variant IL-4

<400>  6

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Lys Cys Ser Ser Gly Gly Asn Gly 
                85                  90                  95      


Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
            100                 105                 110         


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
        115                 120                 125             


Ile Phe Ala Ala Ser 
    130             


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 including an additional methionine at the N-terminus

<400>  7

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  8
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  " A11" IL-13 variant

<400>  8

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  9
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "DN" IL-13 variant

<400>  9

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu 
1               5                   10                  15      


Glu Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  10

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  11

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13 "A11" variant

<400>  12

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Arg Thr Ala Gly 
        115         


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  13

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Arg Thr Ala Gly 
        115             


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "DN" IL-13

<400>  14

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  15

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  16
<211>  232
<212>  PRT
<213>  Homom sapiens

<400>  16

Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu 
1               5                   10                  15      


Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn 
            20                  25                  30          


Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro Ser 
        35                  40                  45              


Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala Val 
    50                  55                  60                  


Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val Ile 
65                  70                  75                  80  


Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe 
                85                  90                  95      


Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His 
            100                 105                 110         


Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu 
        115                 120                 125             


Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser 
    130                 135                 140                 


Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val 
145                 150                 155                 160 


Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His 
                165                 170                 175     


Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu 
            180                 185                 190         


Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg 
        195                 200                 205             


Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val Leu 
    210                 215                 220                 


Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230         


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Lys Ala Ser Gly Gly Pro Glu 
1               5           


<210>  18
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpIL-4-BclxL

<400>  18

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Lys Ala Ser Gly Gly Pro Glu Ser Gln Ser 
    130                 135                 140                 


Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys 
145                 150                 155                 160 


Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu 
                165                 170                 175     


Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn 
            180                 185                 190         


Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala 
        195                 200                 205             


Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala 
    210                 215                 220                 


Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg 
225                 230                 235                 240 


Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro 
                245                 250                 255     


Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg 
            260                 265                 270         


Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly 
        275                 280                 285             


Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser 
    290                 295                 300                 


Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro 
305                 310                 315                 320 


Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly 
                325                 330                 335     


Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg 
            340                 345                 350         


Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val Leu Leu Gly Ser 
        355                 360                 365             


Leu Phe Ser Arg Lys 
    370             


<210>  19
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ubiquitin linker

<400>  19

Gly Gly Gly Ser Met Gln Ile Phe Val Arg Thr Leu Thr Gly Arg Thr 
1               5                   10                  15      


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Arg Ala 
            20                  25                  30          


Arg Ile Gln Asp Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
        35                  40                  45              


Phe Ala Gly Arg Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
    50                  55                  60                  


Ile Gln Arg Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75                  80  


Gly Ser 
        


<210>  20
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpIL-4-Ub-BclxL

<400>  20

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Gly Gly Ser Met Gln Ile Phe Val Arg 
    130                 135                 140                 


Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr 
145                 150                 155                 160 


Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly Ile Pro Pro 
                165                 170                 175     


Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu Asp Gly Arg 
            180                 185                 190         


Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu His Leu Val 
        195                 200                 205             


Leu Arg Leu Arg Gly Gly Gly Ser Ser Gln Ser Asn Arg Glu Leu Val 
    210                 215                 220                 


Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser 
225                 230                 235                 240 


Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr 
                245                 250                 255     


Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser Trp 
            260                 265                 270         


His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser Ser 
        275                 280                 285             


Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln Ala 
    290                 295                 300                 


Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe 
305                 310                 315                 320 


Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln 
                325                 330                 335     


Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp 
            340                 345                 350         


Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu 
        355                 360                 365             


Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp 
    370                 375                 380                 


Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn 
385                 390                 395                 400 


Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala 
                405                 410                 415     


Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly 
            420                 425                 430         


Met Thr Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
        435                 440                 445             


<210>  21
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpKRF4-Ub-BclxL

<400>  21

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Gly Gly Ser Met Gln Ile Phe Val Arg 
    130                 135                 140                 


Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr 
145                 150                 155                 160 


Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly Ile Pro Pro 
                165                 170                 175     


Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu Asp Gly Arg 
            180                 185                 190         


Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu His Leu Val 
        195                 200                 205             


Leu Arg Leu Arg Gly Gly Gly Ser Ser Gln Ser Asn Arg Glu Leu Val 
    210                 215                 220                 


Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp Ser 
225                 230                 235                 240 


Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly Thr 
                245                 250                 255     


Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser Trp 
            260                 265                 270         


His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser Ser 
        275                 280                 285             


Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln Ala 
    290                 295                 300                 


Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala Phe 
305                 310                 315                 320 


Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr Gln 
                325                 330                 335     


Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn Trp 
            340                 345                 350         


Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val Glu 
        355                 360                 365             


Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala Trp 
    370                 375                 380                 


Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu Asn 
385                 390                 395                 400 


Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala 
                405                 410                 415     


Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly 
            420                 425                 430         


Met Thr Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
        435                 440                 445             


<210>  22
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpKFR4-BclxL

<400>  22

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Lys Gly Ser Ser Gln Ser Asn Arg Glu Leu 
    130                 135                 140                 


Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp 
145                 150                 155                 160 


Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly 
                165                 170                 175     


Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser 
            180                 185                 190         


Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser 
        195                 200                 205             


Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln 
    210                 215                 220                 


Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala 
225                 230                 235                 240 


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
                245                 250                 255     


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
            260                 265                 270         


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
        275                 280                 285             


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
    290                 295                 300                 


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
305                 310                 315                 320 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
                325                 330                 335     


Ala Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr 
            340                 345                 350         


Gly Met Thr Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg 
        355                 360                 365             


Lys 
    


<210>  23
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpS4-Ub-BclxL

<400>  23

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Lys Gly Gly Gly Ser Met Gln Ile Phe Val 
    130                 135                 140                 


Arg Thr Leu Thr Gly Arg Thr Ile Thr Leu Glu Val Glu Pro Ser Asp 
145                 150                 155                 160 


Thr Ile Glu Asn Val Arg Ala Arg Ile Gln Asp Arg Glu Gly Ile Pro 
                165                 170                 175     


Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Arg Gln Leu Glu Asp Gly 
            180                 185                 190         


Arg Thr Leu Ser Asp Tyr Asn Ile Gln Arg Glu Ser Thr Leu His Leu 
        195                 200                 205             


Val Leu Arg Leu Arg Gly Gly Gly Ser Ser Gln Ser Asn Arg Glu Leu 
    210                 215                 220                 


Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp 
225                 230                 235                 240 


Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly 
                245                 250                 255     


Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser 
            260                 265                 270         


Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser 
        275                 280                 285             


Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln 
    290                 295                 300                 


Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala 
305                 310                 315                 320 


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
                325                 330                 335     


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
            340                 345                 350         


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
        355                 360                 365             


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
    370                 375                 380                 


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
385                 390                 395                 400 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr 
            420                 425                 430         


Gly Met Thr Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg 
        435                 440                 445             


Lys 
    


<210>  24
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpS4-BclxL

<400>  24

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Lys Gly Ser Ser Gln Ser Asn Arg Glu Leu 
    130                 135                 140                 


Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser Trp 
145                 150                 155                 160 


Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu Gly 
                165                 170                 175     


Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro Ser 
            180                 185                 190         


Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His Ser 
        195                 200                 205             


Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys Gln 
    210                 215                 220                 


Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg Ala 
225                 230                 235                 240 


Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala Tyr 
                245                 250                 255     


Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val Asn 
            260                 265                 270         


Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys Val 
        275                 280                 285             


Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala Ala 
    290                 295                 300                 


Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln Glu 
305                 310                 315                 320 


Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Ala Ala 
                325                 330                 335     


Ala Glu Ser Arg Lys Gly Gln Glu Arg Phe Asn Arg Trp Phe Leu Thr 
            340                 345                 350         


Gly Met Thr Val Ala Gly Val Val Leu Leu Gly Ser Leu Phe Ser Arg 
        355                 360                 365             


Lys 
    


<210>  25
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-4

<400>  25
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc                                       390


<210>  26
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4

<400>  26
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt cc                         402


<210>  27
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpKFR

<400>  27
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gc                         402


<210>  28
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpS4

<400>  28
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt cc                         402


<210>  29
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant BclxL

<400>  29
tctcagtcta accgcgaact ggtggtggac ttcctgtctt ataaactgag ccagaaaggc       60

tactcctgga gccagttcag cgacgtagag gagaaccgta ccgaagctcc tgaaggcacc      120

gagagcgaga tggaaacccc atccgcgatt aacggcaacc cgtcctggca cctggctgat      180

tctccggcgg taaacggcgc aactggtcat tctagctccc tggatgcacg tgaagtaatc      240

ccgatggccg cggttaaaca ggcgctgcgt gaagctggtg acgaatttga gctgcgctac      300

cgccgtgcat tttctgatct gacctcccag ctgcacatca cgccgggtac cgcataccaa      360

agcttcgaac aggtggttaa cgaactgttt cgtgacggcg tcaactgggg ccgcatcgtg      420

gcctttttct ctttcggcgg tgccctgtgc gtcgaatctg ttgacaaaga aatgcaggtt      480

ctggtgagcc gtattgcggc ttggatggca acttatctga acgatcacct ggaaccgtgg      540

atccaggaaa acggtggttg ggataccttc gttgaactgt acggtaacaa tgctgcggcg      600

gaatcccgta agggtcaaga acgtttcaat cgctggttcc tgaccggcat gactgttgct      660

ggtgtagttc tgctgggttc tctgttctcc cgtaaa                                696


<210>  30
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4-BclxL

<400>  30
atggacacga ctgagaaaga gaccttctgc cgtgcagcaa ctgttctgcg tcagttctat       60

tcccaccacg aaaaagatac gcgttgcctg ggtgctactg cgcagcagtt ccatcgtcat      120

aagcaactga ttcgctttct gaaacgtctg gaccgtaacc tgtggggtct ggccggtctg      180

aacagctgcc cggtcaaaga agcgaaccag tccactctgg aaaacttcct ggaacgcctg      240

aagaccatca tgcgcgaaaa atactccaag tgttccagcg gcggcaacgg cggtcacaaa      300

tgtgacatca ccctgcagga aatcatcaaa actctgaatt ctctgactga gcagaaaacc      360

ctgtgtaccg aactgaccgt gaccgatatt tttgccgctt ctaaagcgtc tggtggcccg      420

gaatctcagt ctaaccgcga actggtggtg gacttcctgt cttataaact gagccagaaa      480

ggctactcct ggagccagtt cagcgacgta gaggagaacc gtaccgaagc tcctgaaggc      540

accgagagcg agatggaaac cccatccgcg attaacggca acccgtcctg gcacctggct      600

gattctccgg cggtaaacgg cgcaactggt cattctagct ccctggatgc acgtgaagta      660

atcccgatgg ccgcggttaa acaggcgctg cgtgaagctg gtgacgaatt tgagctgcgc      720

taccgccgtg cattttctga tctgacctcc cagctgcaca tcacgccggg taccgcatac      780

caaagcttcg aacaggtggt taacgaactg tttcgtgacg gcgtcaactg gggccgcatc      840

gtggcctttt tctctttcgg cggtgccctg tgcgtcgaat ctgttgacaa agaaatgcag      900

gttctggtga gccgtattgc ggcttggatg gcaacttatc tgaacgatca cctggaaccg      960

tggatccagg aaaacggtgg ttgggatacc ttcgttgaac tgtacggtaa caatgctgcg     1020

gcggaatccc gtaagggtca agaacgtttc aatcgctggt tcctgaccgg catgactgtt     1080

gctggtgtag ttctgctggg ttctctgttc tcccgtaaa                            1119


<210>  31
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4-Ub-BclxL

<400>  31
atggacacga ctgagaaaga gaccttctgc cgtgcagcaa ctgttctgcg tcagttctat       60

tcccaccacg aaaaagatac gcgttgcctg ggtgctactg cgcagcagtt ccatcgtcat      120

aagcaactga ttcgctttct gaaacgtctg gaccgtaacc tgtggggtct ggccggtctg      180

aacagctgcc cggtcaaaga agcgaaccag tccactctgg aaaacttcct ggaacgcctg      240

aagaccatca tgcgcgaaaa atactccaag tgttccagcg gcggcaacgg cggtcacaaa      300

tgtgacatca ccctgcagga aatcatcaaa actctgaatt ctctgactga gcagaaaacc      360

ctgtgtaccg aactgaccgt gaccgatatt tttgccgctt ctaaaggtgg cggctctatg      420

caaattttcg ttcgtaccct gacgggtcgt accatcactc tggaagtaga accgagcgac      480

acgatcgaaa atgtccgcgc acgcatccaa gaccgcgaag gcattccacc ggatcagcag      540

cgtctgatct tcgccggtcg ccagctggag gatggtcgta ctctgtccga ttataacatc      600

cagcgtgaat ccaccctgca cctggtgctg cgtctgcgtg gcggtggtag ctctcagtct      660

aaccgcgaac tggtggtgga cttcctgtct tataaactga gccagaaagg ctactcctgg      720

agccagttca gcgacgtaga ggagaaccgt accgaagctc ctgaaggcac cgagagcgag      780

atggaaaccc catccgcgat taacggcaac ccgtcctggc acctggctga ttctccggcg      840

gtaaacggcg caactggtca ttctagctcc ctggatgcac gtgaagtaat cccgatggcc      900

gcggttaaac aggcgctgcg tgaagctggt gacgaatttg agctgcgcta ccgccgtgca      960

ttttctgatc tgacctccca gctgcacatc acgccgggta ccgcatacca aagcttcgaa     1020

caggtggtta acgaactgtt tcgtgacggc gtcaactggg gccgcatcgt ggcctttttc     1080

tctttcggcg gtgccctgtg cgtcgaatct gttgacaaag aaatgcaggt tctggtgagc     1140

cgtattgcgg cttggatggc aacttatctg aacgatcacc tggaaccgtg gatccaggaa     1200

aacggtggtt gggatacctt cgttgaactg tacggtaaca atgctgcggc ggaatcccgt     1260

aagggtcaag aacgtttcaa tcgctggttc ctgaccggca tgactgttgc tggtgtagtt     1320

ctgctgggtt ctctgttctc ccgtaaa                                         1347


