                         SEQUENCE LISTING

<110>  Levicept Ltd.
 
<120>  FUSION PROTEIN

<130>  LEV01134GBP1

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  1

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
                165                 170                 175     


Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu 
            180                 185                 190         


Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met 
        195                 200                 205             


Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Asp Ile 
    210                 215                 220                 


Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  2
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  2

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly 
            20                  25                  30          


Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys 
        35                  40                  45              


Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe 
    50                  55                  60                  


Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys 
65                  70                  75                  80  


Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala 
                85                  90                  95      


Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg 
            100                 105                 110         


Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser 
        115                 120                 125             


Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr 
    130                 135                 140                 


Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val 
145                 150                 155                 160 


Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp 
                165                 170                 175     


Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro 
            180                 185                 190         


Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala 
        195                 200                 205             


Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr 
    210                 215                 220                 


Thr Val Met Gly Gly Gly Gly Glu Pro Lys Ser Ser Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  3
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  3

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
                165                 170                 175     


Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu 
            180                 185                 190         


Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met 
        195                 200                 205             


Gly Gly Gly Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  4
<211>  1411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning insert

<400>  4
aagcttgccg ccaccatgga atggtcctgg gtgttcctgt tcttcctgtc cgtgaccacc       60

ggcgtgcact ccaaagaggc ttgtcccacc ggcctgtaca cccactctgg cgagtgttgc      120

aaggcctgta acctgggaga aggcgtggcc cagccttgtg gcgctaatca gacagtgtgc      180

gagccctgcc tggactccgt gaccttctcc gatgtggtgt ccgccaccga gccttgcaag      240

ccctgcacag agtgtgtggg cctgcagtcc atgtccgccc cttgcgtgga agccgacgac      300

gccgtgtgta gatgcgccta cggctactac caggacgaga caaccggcag atgcgaggcc      360

tgcagagtgt gcgaagctgg ctctggcctg gtgttcagtt gtcaagacaa gcagaacacc      420

gtgtgcgagg aatgccccga cggcacctac tctgacgagg ccaatcacgt ggacccctgc      480

ctgccttgca ccgtgtgtga agataccgag cggcagctgc gcgagtgcac cagatgggct      540

gatgccgagt gcgaagagat ccctggccgg tggatcacca gatccacccc tccagagggc      600

tccgactcta ccgctccctc tacccaggaa cctgaggccc ctcctgagca ggacctgatc      660

gcttctacag tggccggcgt cgtgaccaca gtgatgggcg gaggcggcga gcctaagtcc      720

tccgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgtttctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagta caactccacc      960

taccgggtgg tgtctgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tgtccaacaa ggccctgcca gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgac ctgtctcgtg aagggcttct acccctccga tatcgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

agcgacggct cattctttct gtactccaag ctgacagtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgcag cgtgatgcac gaggctctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg ctgatgaatt c                                    1411


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretase site

<400>  5

Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Asp Ile 
1               5                   10                  15      


Glu Gly Arg Met Asp 
            20      


<210>  6
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment.

<400>  6

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser 
1               5                   10                  15      


Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr 
            20                  25                  30          


Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala 
        35                  40                  45              


Phe Lys Arg 
    50      


<210>  7
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  7

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ile Pro 
1               5                   10                  15      


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe 
    50  


<210>  8
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  8

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ile Pro 
1               5                   10                  15      


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe 
    50  


<210>  9
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  9

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ile Pro 
1               5                   10                  15      


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe 
    50  


<210>  10
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  10

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Gly Gly 
1               5                   10                  15      


Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45  


<210>  11
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  11

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Gly Gly 
1               5                   10                  15      


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45      


<210>  12
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  12

Ile Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe 
    50      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence for sequence alignment

<400>  13

Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
1               5                   10                  15      


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            20                  25                  30          


Val Phe Leu Phe 
        35      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  14

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  15
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein

<400>  15

Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys 
1               5                   10                  15      


Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn 
            20                  25                  30          


Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val 
        35                  40                  45              


Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu 
    50                  55                  60                  


Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg 
65                  70                  75                  80  


Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala 
                85                  90                  95      


Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp 
            100                 105                 110         


Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp 
        115                 120                 125             


Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp 
    130                 135                 140                 


Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys 
145                 150                 155                 160 


Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly 
                165                 170                 175     


Gly Gly Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
305                 310                 315                 320 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                405                 410 


