                         SEQUENCE LISTING

<110>  FOLIA BIOTECH INC.
       LAMARRE, Alain
 
<120>  PAPAYA MOSAIC VIRUS AND VIRUS-LIKE PARTICLES IN CANCER THERAPY

<130>  V86634WO

<140>  n/a
<141>  2014-09-19

<150>  61/886,481
<151>  2013-10-03

<150>  61/880,156
<151>  2013-09-19

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  1522
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence encoding synthetic RNA template for VLP production

<400>  1
gggcgaattg gagctcgaaa agaaacacaa agcaaagcaa agcaaagcaa ctcaaataaa       60

ccatatttgg ccaaggcact tggtaatcaa acgggcacaa ccctagatta acgattaagc      120

aaatttgagg agtgttttcg aacagttgaa cgacgtctca ctccgggctg ttattcaaga      180

agaggcctac agagacatta agctcactat taaggaaact aaaacctaca atcctttaac      240

acatccagta gcagtagcag atagtttaga aaaattagga atagaaacta acccctttgc      300

cgtcaaggcg catacgctaa ccgcggcaaa aacaatagaa ttagattaat acaaaatagt      360

ttctttctac ctcccaaagg agaaccccac taccttttaa ttctaaaaga ggagcaagtt      420

gcaatatttt agaagaggcc cacagcaaaa agtaatattc ctcataactc acatagaacc      480

caaagacgtg gctaggttaa acgtggacac cctttttgac aagaacgtga ccccacagat      540

taccacaaac acagcctttt aaggggatac cctccatttt ctcccactaa cagcgattga      600

aaggattttt aaatcctccc ccaacttcaa accctctacg ccacttaagt actcccaccg      660

gaggccctgc ataggctgca ttccctgcac cctggtatat taaaattaga gtttcaccaa      720

gaacatttca tctacaaacc agggggtcta actggggcag cgtacatcca caaatacgag      780

caactcgagt ggattaaagt gggaaggttt aagtgggcgg acgggaaggg gcttacccac      840

acggtgacct cacaaatttt ggaaactaaa ggtgccaacc acctcttcat ttttcagaga      900

gggaggtttc tgactccaga attgaggtgt ttcaacactg agacaaaatt aatcacctaa      960

cctcccatct tcctccccaa gcagtttata acccggttgc caattaagaa aaccaaccgg     1020

tccgcccaac aattgtttct ctacgtaaaa tcagtgaaga taataacaga gagggacatc     1080

tgggcaaagt aaagacagtt gctcaagact tcggagctac aagattacaa tccaagggag     1140

gtggctctgc tggtgaacta ttttctcttg atcgccagat taaggtcgga aacgtgtttt     1200

gacaacgtcc tcagcggggg ataattcaag aaactcttca aacccttcat cgctaagtgg     1260

gagatccaaa aacacaaaat ttttggaata aaggagtttg aacagttata agaagctctg     1320

gataaggtgg taataacact gacctaccca acaaaaactt ttgacaatcg gggttgggtg     1380

gttaagctgg aagcgaggag gggttacgag tggttcgctg taaagtaaca caagccgaag     1440

ggtccagaac taaacttgga ggagaagaaa acggatccgg acgccgcatc ctacgaaaaa     1500

tacttgaaag ccctgaacgc gt                                              1522


<210>  2
<211>  215
<212>  PRT
<213>  Papaya mosaic virus


<220>
<221>  
<223>  wild-type PapMV coat protein

<400>  2

Met Ser Lys Ser Ser Met Ser Thr Pro Asn Ile Ala Phe Pro Ala Ile 
1               5                   10                  15      


Thr Gln Glu Gln Met Ser Ser Ile Lys Val Asp Pro Thr Ser Asn Leu 
            20                  25                  30          


Leu Pro Ser Gln Glu Gln Leu Lys Ser Val Ser Thr Leu Met Val Ala 
        35                  40                  45              


Ala Lys Val Pro Ala Ala Ser Val Thr Thr Val Ala Leu Glu Leu Val 
    50                  55                  60                  


Asn Phe Cys Tyr Asp Asn Gly Ser Ser Ala Tyr Thr Thr Val Thr Gly 
65                  70                  75                  80  


Pro Ser Ser Ile Pro Glu Ile Ser Leu Ala Gln Leu Ala Ser Ile Val 
                85                  90                  95      


Lys Ala Ser Gly Thr Ser Leu Arg Lys Phe Cys Arg Tyr Phe Ala Pro 
            100                 105                 110         


Ile Ile Trp Asn Leu Arg Thr Asp Lys Met Ala Pro Ala Asn Trp Glu 
        115                 120                 125             


Ala Ser Gly Tyr Lys Pro Ser Ala Lys Phe Ala Ala Phe Asp Phe Phe 
    130                 135                 140                 


Asp Gly Val Glu Asn Pro Ala Ala Met Gln Pro Pro Ser Gly Leu Ile 
145                 150                 155                 160 


Arg Ser Pro Thr Gln Glu Glu Arg Ile Ala Asn Ala Thr Asn Lys Gln 
                165                 170                 175     


Val His Leu Phe Gln Ala Ala Ala Gln Asp Asn Asn Phe Thr Ser Asn 
            180                 185                 190         


Ser Ala Phe Ile Thr Lys Gly Gln Ile Ser Gly Ser Thr Pro Thr Ile 
        195                 200                 205             


Gln Phe Leu Pro Pro Pro Glu 
    210                 215 


<210>  3
<211>  648
<212>  DNA
<213>  Papaya mosaic virus


<220>
<221>  
<223>  sequence encoding wild-type PapMV coat protein

<400>  3
atgtctaagt caagtatgtc cacacccaac atagccttcc ccgccatcac ccaggaacag       60

atgagctcga ttaaggtcga tccaacgtcc aatcttctgc cctcccaaga gcagttaaag      120

tcagtgtcca ccctcatggt agctgctaag gttccagcag ccagtgttac aactgtggca      180

ttggagttgg tcaacttctg ctatgacaat gggtccagcg cgtacaccac agtgactggc      240

ccatcatcaa taccggagat atcactggca caattggcta gtattgtcaa agcttccggc      300

acttccctta gaaaattctg ccggtacttc gcgccaataa tctggaatct gaggacggac      360

aaaatggctc ctgccaattg ggaggcttca ggatacaagc caagcgccaa atttgccgcg      420

ttcgacttct tcgacggggt ggagaatccg gcggccatgc aacccccttc gggactaatc      480

aggtcgccga cccaggaaga gcggattgcc aatgctacca acaaacaggt gcatctcttc      540

caagccgcgg cacaggacaa caactttacc agcaactccg ccttcatcac caaaggccaa      600

atttctgggt caaccccaac catccaattc cttccacccc ccgaataa                   648


<210>  4
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  modified PapMV coat protein CPdeltaN5

<400>  4

Met Ala Ser Thr Pro Asn Ile Ala Phe Pro Ala Ile Thr Gln Glu Gln 
1               5                   10                  15      


Met Ser Ser Ile Lys Val Asp Pro Thr Ser Asn Leu Leu Pro Ser Gln 
            20                  25                  30          


Glu Gln Leu Lys Ser Val Ser Thr Leu Met Val Ala Ala Lys Val Pro 
        35                  40                  45              


Ala Ala Ser Val Thr Thr Val Ala Leu Glu Leu Val Asn Phe Cys Tyr 
    50                  55                  60                  


Asp Asn Gly Ser Ser Ala Tyr Thr Thr Val Thr Gly Pro Ser Ser Ile 
65                  70                  75                  80  


Pro Glu Ile Ser Leu Ala Gln Leu Ala Ser Ile Val Lys Ala Ser Gly 
                85                  90                  95      


Thr Ser Leu Arg Lys Phe Cys Arg Tyr Phe Ala Pro Ile Ile Trp Asn 
            100                 105                 110         


Leu Arg Thr Asp Lys Met Ala Pro Ala Asn Trp Glu Ala Ser Gly Tyr 
        115                 120                 125             


Lys Pro Ser Ala Lys Phe Ala Ala Phe Asp Phe Phe Asp Gly Val Glu 
    130                 135                 140                 


Asn Pro Ala Ala Met Gln Pro Pro Ser Gly Leu Thr Arg Ser Pro Thr 
145                 150                 155                 160 


Gln Glu Glu Arg Ile Ala Asn Ala Thr Asn Lys Gln Val His Leu Phe 
                165                 170                 175     


Gln Ala Ala Ala Gln Asp Asn Asn Phe Ala Ser Asn Ser Ala Phe Ile 
            180                 185                 190         


Thr Lys Gly Gln Ile Ser Gly Ser Thr Pro Thr Ile Gln Phe Leu Pro 
        195                 200                 205             


Pro Pro Glu 
    210     


<210>  5
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  modified PapMV coat protein PapMV CPsm

<400>  5

Met Ala Ser Thr Pro Asn Ile Ala Phe Pro Ala Ile Thr Gln Glu Gln 
1               5                   10                  15      


Met Ser Ser Ile Lys Val Asp Pro Thr Ser Asn Leu Leu Pro Ser Gln 
            20                  25                  30          


Glu Gln Leu Lys Ser Val Ser Thr Leu Met Val Ala Ala Lys Val Pro 
        35                  40                  45              


Ala Ala Ser Val Thr Thr Val Ala Leu Glu Leu Val Asn Phe Cys Tyr 
    50                  55                  60                  


Asp Asn Gly Ser Ser Ala Tyr Thr Thr Val Thr Gly Pro Ser Ser Ile 
65                  70                  75                  80  


Pro Glu Ile Ser Leu Ala Gln Leu Ala Ser Ile Val Lys Ala Ser Gly 
                85                  90                  95      


Thr Ser Leu Arg Lys Phe Cys Arg Tyr Phe Ala Pro Ile Ile Trp Asn 
            100                 105                 110         


Leu Arg Thr Asp Lys Met Ala Pro Ala Asn Trp Glu Ala Ser Gly Tyr 
        115                 120                 125             


Lys Pro Ser Ala Lys Phe Ala Ala Phe Asp Phe Phe Asp Gly Val Glu 
    130                 135                 140                 


Asn Pro Ala Ala Met Gln Pro Pro Ser Gly Leu Thr Arg Ser Pro Thr 
145                 150                 155                 160 


Gln Glu Glu Arg Ile Ala Asn Ala Thr Asn Lys Gln Val His Leu Phe 
                165                 170                 175     


Gln Ala Ala Ala Gln Asp Asn Asn Phe Ala Ser Asn Ser Ala Phe Ile 
            180                 185                 190         


Thr Lys Gly Gln Ile Ser Gly Ser Thr Pro Thr Ile Gln Phe Leu Pro 
        195                 200                 205             


Pro Pro Glu Thr Ser Thr Thr Arg His His His His His His 
    210                 215                 220         


<210>  6
<211>  2662
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sequence encoding synthetic RNA template for VLP production

<400>  6
gggcgaattg gagctcgaaa agaaacacaa agcaaagcaa agcaaagcaa ctcaaataaa       60

ccatatttgg ccaaggcact tggtaatcaa acgggcacaa ccctagatta acgattaagc      120

aaatttgagg agtgttttcg aacagttgaa cgacgtctca ctccgggctg ttattcaaga      180

agaggcctac agagacatta agctcactat taaggaaact aaaacctaca atcctttaac      240

acatccagta gcagtagcag atagtttaga aaaattagga atagaaacta acccctttgc      300

cgtcaaggcg catacgctaa ccgcggcaaa aacaatagaa ttagattaat acaaaatagt      360

ttctttctac ctcccaaagg agaaccccac taccttttaa ttctaaaaga ggagcaagtt      420

gcaatatttt agaagaggcc cacagcaaaa agtaatattc ctcataactc acatagaacc      480

caaagacgtg gctaggttaa acgtggacac cctttttgac aagaacgtga ccccacagat      540

taccacaaac acagcctttt aaggggatac cctccatttt ctcccactaa cagcgattga      600

aaggattttt aaatcctccc ccaacttcaa accctctacg ccacttaagt actcccaccg      660

gaggccctgc ataggctgca ttccctgcac cctggtatat taaaattaga gtttcaccaa      720

gaacatttca tctacaaacc agggggtcta actggggcag cgtacatcca caaatacgag      780

caactcgagt ggattaaagt gggaaggttt aagtgggcgg acgggaaggg gcttacccac      840

acggtgacct cacaaatttt ggaaactaaa ggtgccaacc acctcttcat ttttcagaga      900

gggaggtttc tgactccaga attgaggtgt ttcaacactg agacaaaatt aatcacctaa      960

cctcccatct tcctccccaa gcagtttata acccggttgc caattaagaa aaccaaccgg     1020

tccgcccaac aattgtttct ctacgtaaaa tcagtgaaga taataacaga gagggacatc     1080

tgggcaaagt aaagacagtt gctcaagact tcggagctac aagattacaa tccaagggag     1140

gtggctctgc tggtgaacta ttttctcttg atcgccagat taaggtcgga aacgtgtttt     1200

gacaacgtcc tcagcggggg ataattcaag aaactcttca aacccttcat cgctaagtgg     1260

gagatccaaa aacacaaaat ttttggaata aaggagtttg aacagttata agaagctctg     1320

gataaggtgg taataacact gacctaccca acaaaaactt ttgacaatcg gggttgggtg     1380

gttaagctgg aagcgaggag gggttacgag tggttcgctg taaagtaaca caagccgaag     1440

ggtccagaac taaacttgga ggagaagaaa acggatccgg acgccgcatc ctacgaaaaa     1500

tacttgaaag ccctgaacgc gtgccttttg cagaaagaac cggaggtcta agaagccaaa     1560

gaagcagagg caacagtaaa accccaaagg cccgaaatta aggaagagca ggcggaggct     1620

tccacgagtg ggagggctga agaaattcaa gaggatccgg caaccaggaa agggaaggag     1680

gagccgaacc ccaatcggga cctgctctgc cctaacggat tacatctaaa gatcaaaata     1740

accgaatttc ctgaacttcc ggtactcgat catccagatc atctcaccgg aagaaaagct     1800

aagttctttt caaaggtaag aaagccatac tcctacacag gaggctcact aacatctcga     1860

ggctggccaa attggctgga gaaaatttta gctgcaatag aaatcaaaga gccactgccg     1920

gaattcaacc ataacttagt ccagcagttt aaactccaag cggccatccc attccaccga     1980

gtaataaaac cgtgttatcc aaagggtcac caggttggcg ccctcaccat caaccactcg     2040

ggagataacc tcacccaaat agcttgccaa aaaggaaagg caagtataac ctaaggattc     2100

ggggactact acttgagccc agtgggattc caagagtccc acaagctaac ggtgagcaac     2160

accacagggg gaagggtgtc tctgaccttc agtaacacag tccagcaaaa caaatttata     2220

ataataagaa gttaagaagc ccttaataac cttccttgga aagcgtggat cccgaaactg     2280

caaaatttag gattccaagg acggcagctt cagttaaatc ctataagagc actgattagc     2340

cccactgagg aaattcgaag ctaacccaag tgtaagcctg aaggggttcc agaagtagtt     2400

tacaagacgc tggacggact agctcgtgcg ccaactccat attcgccaaa ccctatccga     2460

gctagagcat acacctcagt aatcaaaaac tgcagaattg gggccctgct aaggcaacaa     2520

ggtaaggagt ggggtaacag gtttgtaaca ttggtagaag ctggcaagag agagttggcc     2580

atccccgtaa ttcacggagc gggaggaagt gggaagtcac aagcattgca gaccctgatt     2640

aaggacaacc cagagcttga ta                                              2662


<210>  7
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OVA peptide

<400>  7

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


