                         SEQUENCE LISTING

<110>  University Health Network (UHN): Technology Development and
        Commercialization
       
 
<120>  AGENTS DIRECTED AGAINST A CIS RGMA/NEOGENIN INTERACTION OR LIPID 
       RAFTS AND USE OF THE SAME IN METHODS OF TREATMENT

<130>  31609-2238

<150>  US 61/878,827
<151>  2013-09-17

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1443
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<223>  Neogenin - Accession No. AAC59662

<400>  1

Arg Ser Gly Pro Arg Ser Pro Leu Thr Gly Ser Val Val Arg Thr Phe 
1               5                   10                  15      


Thr Pro Phe Tyr Phe Leu Val Glu Pro Met Asp Ile Leu Ser Val Arg 
            20                  25                  30          


Gly Ala Ser Val Ile Met Asn Cys Ser Ser Tyr Cys Glu Thr Pro Pro 
        35                  40                  45              


Lys Ile Glu Trp Lys Lys Asp Gly Thr Leu Leu Asn Leu Val Ser Asp 
    50                  55                  60                  


Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Leu Ile Asn Ser Val 
65                  70                  75                  80  


Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln Cys Val 
                85                  90                  95      


Ala Thr Val Glu Ser Leu Gly Ser Ile Val Ser Arg Thr Ala Lys Leu 
            100                 105                 110         


Thr Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Leu Ser Ser 
        115                 120                 125             


Val Tyr Lys Gly Asn Ser Ala Ile Leu Asn Cys Glu Val Asn Val Asp 
    130                 135                 140                 


Leu Ala Pro Phe Val Arg Trp Glu Gln Asp Arg Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Asp Asp Arg Val Phe Lys Leu Pro Ser Gly Ala Leu Leu Ile Gly Asn 
                165                 170                 175     


Ala Thr Asp Thr Asp Gly Gly Phe Tyr Arg Cys Val Ile Glu Ser Gly 
            180                 185                 190         


Gly Thr Pro Lys Tyr Ser Glu Glu Ala Glu Leu Lys Ile Leu Pro Asp 
        195                 200                 205             


Pro Glu Glu Pro Gln Ser Leu Val Phe Val Arg Gln Pro Ser Ser Leu 
    210                 215                 220                 


Thr Lys Val Thr Gly Gln Asn Ala Val Phe Pro Cys Val Ala Gly Gly 
225                 230                 235                 240 


Phe Pro Thr Pro Tyr Val Arg Trp Thr Lys Asn Gly Glu Glu Leu Ile 
                245                 250                 255     


Thr Glu Asp Ser Glu Arg Phe Ala Leu Arg Ala Gly Gly Ser Leu Leu 
            260                 265                 270         


Ile Ser Asp Val Thr Glu Glu Asp Val Gly Thr Tyr Thr Cys Ile Ala 
        275                 280                 285             


Asp Asn Glu Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Ala Val Gln 
    290                 295                 300                 


Val Pro Pro Glu Phe Leu Lys Arg Pro Ala Asn Ile Tyr Ala His Glu 
305                 310                 315                 320 


Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro Thr Pro 
                325                 330                 335     


Thr Val Lys Trp Val Lys Asn Gly Asp Val Val Ile Pro Ser Asp Tyr 
            340                 345                 350         


Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu Val Lys 
        355                 360                 365             


Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val Gly Asn 
    370                 375                 380                 


Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Asp Leu Asp Val Ala Ile 
385                 390                 395                 400 


Pro Thr Leu Pro Pro Thr Ser Leu Thr Ser Ala Thr Asn Asp His Leu 
                405                 410                 415     


Ala Pro Ala Thr Thr Gly Pro Leu Pro Thr Ala Pro Arg Asp Val Val 
            420                 425                 430         


Ala Thr Leu Val Ser Thr Arg Phe Ile Arg Leu Thr Trp Arg Thr Pro 
        435                 440                 445             


Val Ser Asp Pro Gln Gly Asp Asn Leu Thr Tyr Ser Ile Phe Tyr Thr 
    450                 455                 460                 


Lys Glu Gly Ile Asn Arg Glu Arg Val Glu Asn Thr Ser Arg Pro Gly 
465                 470                 475                 480 


Glu Thr Gln Val Met Ile Gln Asn Leu Met Pro Glu Thr Val Tyr Val 
                485                 490                 495     


Phe Arg Val Val Ala Gln Asn Lys His Gly His Gly Glu Ser Ser Ala 
            500                 505                 510         


Pro Leu Lys Val Ala Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala 
        515                 520                 525             


Pro Asn Ile Arg Ala Tyr Ala Gly Ser Pro Thr Ser Val Thr Val Thr 
    530                 535                 540                 


Trp Glu Thr Pro Leu Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu 
545                 550                 555                 560 


Tyr Tyr Met Glu Lys Gly Gln Asp Ser Glu Gln Asp Val Asp Val Ala 
                565                 570                 575     


Gly Leu Ser Tyr Thr Ile Thr Gly Leu Lys Lys Tyr Thr Glu Tyr Ser 
            580                 585                 590         


Phe Arg Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Gln 
        595                 600                 605             


Asp Val Val Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln 
    610                 615                 620                 


Asn Leu Thr Leu Glu Ala Arg Asn Ser Lys Ser Ile Met Leu His Trp 
625                 630                 635                 640 


Gln Pro Pro Pro Ala Gly Thr His Ser Gly Gln Ile Thr Gly Tyr Lys 
                645                 650                 655     


Ile Arg Tyr Arg Lys Val Ser Arg Lys Ser Asp Val Thr Glu Ser Val 
            660                 665                 670         


Gly Gly Thr Gln Leu Phe Gln Leu Ile Glu Gly Leu Glu Arg Gly Thr 
        675                 680                 685             


Glu Tyr Asn Phe Arg Ile Ala Ala Met Thr Val Asn Gly Thr Gly Pro 
    690                 695                 700                 


Ala Thr Asp Trp Val Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu 
705                 710                 715                 720 


Ser Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val 
                725                 730                 735     


Thr Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val 
            740                 745                 750         


Val Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln 
        755                 760                 765             


Thr Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu 
    770                 775                 780                 


Asp Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val 
785                 790                 795                 800 


Gly Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Ser 
                805                 810                 815     


Asp Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro 
            820                 825                 830         


Val Pro Asp Pro Ser Pro Met Met Pro Pro Val Gly Val Gln Ala Ser 
        835                 840                 845             


Ile Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu 
    850                 855                 860                 


Pro Lys Asn Gln Lys Ile Thr Asp Ala Arg Tyr Tyr Thr Val Arg Trp 
865                 870                 875                 880 


Lys Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Thr Ala Asn Ala Thr 
                885                 890                 895     


Thr Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu 
            900                 905                 910         


Phe Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met 
        915                 920                 925             


Thr Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys 
    930                 935                 940                 


Asp Val Thr Val Val Ser Lys Glu Gly Lys Pro Arg Thr Ile Ile Val 
945                 950                 955                 960 


Asn Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile 
                965                 970                 975     


Ile Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile 
            980                 985                 990         


Glu Pro Val Val Gly Asn Arg Leu  Thr His Gln Ile Gln  Glu Leu Thr 
        995                 1000                 1005             


Leu Asp  Thr Pro Tyr Tyr Phe  Lys Ile Gln Ala Arg  Asn Ser Lys 
    1010                 1015                 1020             


Gly Met  Gly Pro Met Ser Glu  Ala Val Gln Phe Arg  Thr Pro Lys 
    1025                 1030                 1035             


Ala Glu  Ser Ser Asp Lys Met  Pro Asn Asp Gln Ala  Ser Gly Ser 
    1040                 1045                 1050             


Ala Gly  Lys Gly Ser Arg Pro  Val Asp Val Gly Pro  Asp Tyr Lys 
    1055                 1060                 1065             


Pro Pro  Leu Ser Gly Ser Asn  Ser Pro His Gly Ser  Pro Thr Ser 
    1070                 1075                 1080             


Pro Leu  Asp Ser Asn Met Leu  Leu Val Ile Ile Val  Ser Val Gly 
    1085                 1090                 1095             


Val Ile  Thr Ile Val Ile Val  Val Ile Val Ala Val  Phe Cys Thr 
    1100                 1105                 1110             


Arg Arg  Thr Thr Ser His Gln  Lys Lys Lys Arg Ala  Ala Cys Lys 
    1115                 1120                 1125             


Ser Val  Asn Gly Ser His Lys  Tyr Lys Gly Asn Ser  Lys Asp Val 
    1130                 1135                 1140             


Lys Pro  Pro Asp Leu Trp Ile  His His Glu Arg Leu  Glu Leu Lys 
    1145                 1150                 1155             


Pro Ile  Asp Lys Ser Pro Asp  Pro Asn Pro Ile Met  Thr Asp Thr 
    1160                 1165                 1170             


Pro Ile  Pro Arg Asn Ser Gln  Asp Ile Thr Pro Val  Asp Asn Ser 
    1175                 1180                 1185             


Met Asp  Ser Asn Ile His Gln  Arg Arg Asn Ser Tyr  Arg Gly His 
    1190                 1195                 1200             


Glu Ser  Glu Asp Ser Met Ser  Thr Leu Ala Gly Arg  Arg Gly Met 
    1205                 1210                 1215             


Arg Pro  Lys Met Met Met Pro  Phe Asp Ser Gln Pro  Pro Gln Pro 
    1220                 1225                 1230             


Val Ile  Ser Ala His Pro Ile  His Ser Leu Asp Asn  Pro His His 
    1235                 1240                 1245             


His Phe  His Ser Gly Ser Leu  Ala Ser Pro Thr Arg  Ser Tyr Leu 
    1250                 1255                 1260             


His His  Gln Val Ser Pro Trp  Pro Val Gly Thr Ser  Met Ser His 
    1265                 1270                 1275             


Ser Asp  Arg Ala Asn Ser Thr  Glu Ser Val Arg Asn  Thr Pro Ser 
    1280                 1285                 1290             


Ser Asp  Thr Met Pro Ala Ser  Ser Ser Gln Pro Cys  Ala Asp His 
    1295                 1300                 1305             


Gln Asp  Pro Asp Ser Ser Ser  Gly Ala Tyr Leu Gly  Ser Ala Gln 
    1310                 1315                 1320             


Glu Glu  Asp Ala Ala Gln Ser  Leu Pro Thr Ala His  Val Arg Pro 
    1325                 1330                 1335             


Ser His  Pro Leu Lys Ser Phe  Ala Val Pro Ala Val  Pro Ala Ala 
    1340                 1345                 1350             


Gly Ser  Ala Tyr Asp Pro Thr  Leu Pro Ser Thr Pro  Leu Leu Thr 
    1355                 1360                 1365             


Gln Gln  Ala Pro Ser His Pro  Val His Ser Val Lys  Thr Ala Ser 
    1370                 1375                 1380             


Ile Gly  Thr Leu Gly Arg Thr  Arg Pro Pro Met Pro  Val Val Val 
    1385                 1390                 1395             


Pro Ser  Ala Pro Asp Val Gln  Glu Thr Thr Arg Met  Leu Glu Asp 
    1400                 1405                 1410             


Ser Glu  Ser Ser Tyr Glu Pro  Asp Glu Leu Thr Lys  Glu Met Ala 
    1415                 1420                 1425             


His Leu  Glu Gly Leu Met Lys  Asp Leu Asn Ala Ile  Thr Thr Ala 
    1430                 1435                 1440             


<210>  2
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-Raft - amino acids 28-73 of RGMa

<400>  2

Ser Pro Cys Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ala Ala Thr 
1               5                   10                  15      


Ser Gly Ser His His Leu Gly Ala Glu Glu Thr Pro Glu Phe Cys Thr 
            20                  25                  30          


Ala Leu Arg Ala Tyr Ala His Cys Thr Arg Arg Thr Ala Arg 
        35                  40                  45      


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acids 54-73 of RGMa

<400>  3

Thr Pro Glu Phe Cys Thr Ala Leu Arg Ala Tyr Ala His Cys Thr Arg 
1               5                   10                  15      


Arg Thr Ala Arg 
            20  


<210>  4
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acids 40-62 of RGMa

<400>  4

Trp Ala Ala Thr Ser Gly Ser His His Leu Gly Ala Glu Glu Thr Pro 
1               5                   10                  15      


Glu Phe Cys Thr Ala Leu Arg 
            20              


<210>  5
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Noggin - Accession No. AAA83259

<400>  5

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  6
<211>  432
<212>  PRT
<213>  Gallus gallus


<220>
<221>  MISC_FEATURE
<223>  RGMa - Accession No. NP_989868.1

<400>  6

Met Gly Arg Gly Ala Gly Ser Thr Ala Leu Gly Leu Phe Gln Ile Leu 
1               5                   10                  15      


Pro Val Phe Leu Cys Ile Phe Pro Pro Val Thr Ser Pro Cys Lys Ile 
            20                  25                  30          


Leu Lys Cys Asn Ser Glu Phe Trp Ala Ala Thr Ser Gly Ser His His 
        35                  40                  45              


Leu Gly Ala Glu Glu Thr Pro Glu Phe Cys Thr Ala Leu Arg Ala Tyr 
    50                  55                  60                  


Ala His Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu Ala 
65                  70                  75                  80  


Tyr His Ser Ala Val His Gly Ile Asp Asp Leu Met Val Gln His Asn 
                85                  90                  95      


Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr Leu Pro 
            100                 105                 110         


Pro Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile Cys His Tyr 
        115                 120                 125             


Glu Lys Ser Phe His Lys His Ser Ala Ala Pro Asn Tyr Thr His Cys 
    130                 135                 140                 


Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp Thr Phe Gln 
145                 150                 155                 160 


Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu 
                165                 170                 175     


Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Gly Ser Ser Ala Thr 
            180                 185                 190         


Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Ser Phe Gln Glu Cys Val 
        195                 200                 205             


Glu Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ala Ala Phe 
    210                 215                 220                 


Ala Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn Ser Leu 
225                 230                 235                 240 


Lys Ile Thr Glu Lys Val Ser Gly Gln His Ile Glu Ile Gln Ala Lys 
                245                 250                 255     


Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr Leu Thr 
            260                 265                 270         


Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val Glu Asp Arg 
        275                 280                 285             


Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro Leu Asn Gln 
    290                 295                 300                 


Gln Ile Asp Phe Gln Thr Phe Arg Leu Ala Gln Ala Ala Glu Gly Arg 
305                 310                 315                 320 


Ala Arg Arg Lys Gly Pro Ser Leu Pro Ala Pro Pro Glu Ala Phe Thr 
                325                 330                 335     


Tyr Glu Ser Ala Thr Ala Lys Cys Arg Glu Lys Leu Pro Val Glu Asp 
            340                 345                 350         


Leu Tyr Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp Val 
        355                 360                 365             


Asn Phe Met Leu Ala Ala Tyr Tyr Ala Phe Glu Asp Val Lys Met Leu 
    370                 375                 380                 


His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg Thr Arg Ala Leu 
385                 390                 395                 400 


Ala Pro Gly Asn Ala Ala Pro Ser Glu His Pro Trp Ala Leu Pro Ala 
                405                 410                 415     


Leu Trp Val Ala Leu Leu Ser Leu Ser Gln Cys Trp Leu Gly Leu Leu 
            420                 425                 430         


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acids 40-73 of RGMa

<400>  7

Trp Ala Ala Thr Ser Gly Ser His His Leu Gly Ala Glu Glu Thr Pro 
1               5                   10                  15      


Glu Phe Cys Thr Ala Leu Arg Ala Tyr Ala His Cys Thr Arg Arg Thr 
            20                  25                  30          


Ala Arg 
        


<210>  8
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4Ig domain of Human Neogenin

<400>  8

Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe 
1               5                   10                  15      


Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala 
            20                  25                  30          


Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg 
        35                  40                  45              


Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser 
    50                  55                  60                  


Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro 
65                  70                  75                  80  


Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val 
                85                  90                  95      


Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser 
            100                 105                 110         


Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln 
        115                 120                 125             


Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala 
    130                 135                 140                 


Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro 
145                 150                 155                 160 


Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn 
                165                 170                 175     


Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu 
            180                 185                 190         


Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile 
        195                 200                 205             


Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu 
    210                 215                 220                 


Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu 
225                 230                 235                 240 


Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser 
                245                 250                 255     


Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala 
            260                 265                 270         


Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala 
        275                 280                 285             


Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser 
    290                 295                 300                 


Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys 
305                 310                 315                 320 


Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr 
                325                 330                 335     


Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala 
            340                 345                 350         


His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro 
        355                 360                 365             


Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser 
    370                 375                 380                 


Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu 
385                 390                 395                 400 


Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val 
                405                 410                 415     


Gly 
    


<210>  9
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse N-RGMc

<400>  9

Met Gly Gln Ser Pro Ser Pro Arg Ser Pro His Gly Ser Pro Pro Thr 
1               5                   10                  15      


Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly Gln Ala His Ser 
            20                  25                  30          


Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu 
        35                  40                  45              


Ser Leu Arg Gly Gly Gly Ser Pro Asp Thr Pro Arg Gly Gly Gly Arg 
    50                  55                  60                  


Gly Gly Leu Ala Ser Gly Gly Leu Cys Arg Ala Leu Arg Ser Tyr Ala 
65                  70                  75                  80  


Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu Ala Phe 
                85                  90                  95      


His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile Gln His Asn Cys 
            100                 105                 110         


Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Ala Arg Gly Pro Ala Leu 
        115                 120                 125             


Pro Gly Ala Gly Pro Ala Pro Leu Thr Pro Asp Pro Cys Asp Tyr Glu 
    130                 135                 140                 


Ala Arg Phe Ser Arg Leu His Gly Arg Ala Pro Gly Phe Leu His Cys 
145                 150                 155                 160 


Ala Ser Phe Gly Asp 
                165 


<210>  10
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse N-RGMa

<400>  10

Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp 
1               5                   10                  15      


Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Leu Trp Pro 
            20                  25                  30          


Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Ile Ser Pro Cys 
        35                  40                  45              


Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Ser Gly 
    50                  55                  60                  


Ser His Ala Pro Ala Ser Asp Asp Val Pro Glu Phe Cys Ala Ala Leu 
65                  70                  75                  80  


Arg Thr Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
                85                  90                  95      


Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser 
            100                 105                 110         


Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Val Arg 
        115                 120                 125             


Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu 
    130                 135                 140                 


Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Ala Pro Asn 
145                 150                 155                 160 


Tyr Thr 
        


<210>  11
<211>  1450
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Neogenin - Accession No. AAI43272

<400>  11

Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe 
1               5                   10                  15      


Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala 
            20                  25                  30          


Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg 
        35                  40                  45              


Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser 
    50                  55                  60                  


Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro 
65                  70                  75                  80  


Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val 
                85                  90                  95      


Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser 
            100                 105                 110         


Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln 
        115                 120                 125             


Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala 
    130                 135                 140                 


Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro 
145                 150                 155                 160 


Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn 
                165                 170                 175     


Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu 
            180                 185                 190         


Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile 
        195                 200                 205             


Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu 
    210                 215                 220                 


Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu 
225                 230                 235                 240 


Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser 
                245                 250                 255     


Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala 
            260                 265                 270         


Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala 
        275                 280                 285             


Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser 
    290                 295                 300                 


Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys 
305                 310                 315                 320 


Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr 
                325                 330                 335     


Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala 
            340                 345                 350         


His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro 
        355                 360                 365             


Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser 
    370                 375                 380                 


Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu 
385                 390                 395                 400 


Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val 
                405                 410                 415     


Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro 
            420                 425                 430         


Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser 
        435                 440                 445             


Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser 
    450                 455                 460                 


Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu 
465                 470                 475                 480 


Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met 
                485                 490                 495     


Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg 
            500                 505                 510         


Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu 
        515                 520                 525             


Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn 
    530                 535                 540                 


Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu 
545                 550                 555                 560 


Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr 
                565                 570                 575     


Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His 
            580                 585                 590         


Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg 
        595                 600                 605             


Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val 
    610                 615                 620                 


Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu 
625                 630                 635                 640 


Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro 
                645                 650                 655     


Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg 
            660                 665                 670         


Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser 
        675                 680                 685             


Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu 
    690                 695                 700                 


Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala 
705                 710                 715                 720 


Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr 
                725                 730                 735     


Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr 
            740                 745                 750         


Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val 
        755                 760                 765             


Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr 
    770                 775                 780                 


Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp 
785                 790                 795                 800 


Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly 
                805                 810                 815     


Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp 
            820                 825                 830         


Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val 
        835                 840                 845             


Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile 
    850                 855                 860                 


Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro 
865                 870                 875                 880 


Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys 
                885                 890                 895     


Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr 
            900                 905                 910         


Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe 
        915                 920                 925             


Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr 
    930                 935                 940                 


Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp 
945                 950                 955                 960 


Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn 
                965                 970                 975     


Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Ser Thr Asp Val Asn Ala  Glu Ile His Asp Trp  Val Ile Glu 
        995                 1000                 1005             


Pro Val  Val Gly Asn Arg Leu  Thr His Gln Ile Gln  Glu Leu Thr 
    1010                 1015                 1020             


Leu Asp  Thr Pro Tyr Tyr Phe  Lys Ile Gln Ala Arg  Asn Ser Lys 
    1025                 1030                 1035             


Gly Met  Gly Pro Met Ser Glu  Ala Val Gln Phe Arg  Thr Pro Lys 
    1040                 1045                 1050             


Ala Ser  Gly Ser Gly Gly Lys  Gly Ser Arg Leu Pro  Asp Leu Gly 
    1055                 1060                 1065             


Ser Asp  Tyr Lys Pro Pro Met  Ser Gly Ser Asn Ser  Pro His Gly 
    1070                 1075                 1080             


Ser Pro  Thr Ser Pro Leu Asp  Ser Asn Met Leu Leu  Val Ile Ile 
    1085                 1090                 1095             


Val Ser  Val Gly Val Ile Thr  Ile Val Val Val Val  Ile Ile Ala 
    1100                 1105                 1110             


Val Phe  Cys Thr Arg Arg Thr  Thr Ser His Gln Lys  Lys Lys Arg 
    1115                 1120                 1125             


Ala Ala  Cys Lys Ser Val Asn  Gly Ser His Lys Tyr  Lys Gly Asn 
    1130                 1135                 1140             


Ser Lys  Asp Val Lys Pro Pro  Asp Leu Trp Ile His  His Glu Arg 
    1145                 1150                 1155             


Leu Glu  Leu Lys Pro Ile Asp  Lys Ser Pro Asp Pro  Asn Pro Ile 
    1160                 1165                 1170             


Met Thr  Asp Thr Pro Ile Pro  Arg Asn Ser Gln Asp  Ile Thr Pro 
    1175                 1180                 1185             


Val Asp  Asn Ser Met Asp Ser  Asn Ile His Gln Arg  Arg Asn Ser 
    1190                 1195                 1200             


Tyr Arg  Gly His Glu Ser Glu  Asp Ser Met Ser Thr  Leu Ala Gly 
    1205                 1210                 1215             


Arg Arg  Gly Met Arg Pro Lys  Met Met Met Pro Phe  Asp Ser Gln 
    1220                 1225                 1230             


Pro Pro  Gln Pro Val Ile Ser  Ala His Pro Ile His  Ser Leu Asp 
    1235                 1240                 1245             


Asn Pro  His His His Phe His  Ser Ser Ser Leu Ala  Ser Pro Ala 
    1250                 1255                 1260             


Arg Ser  His Leu Tyr His Pro  Gly Ser Pro Trp Pro  Ile Gly Thr 
    1265                 1270                 1275             


Ser Met  Ser Leu Ser Asp Arg  Ala Asn Ser Thr Glu  Ser Val Arg 
    1280                 1285                 1290             


Asn Thr  Pro Ser Thr Asp Thr  Met Pro Ala Ser Ser  Ser Gln Thr 
    1295                 1300                 1305             


Cys Cys  Thr Asp His Gln Asp  Pro Glu Gly Ala Thr  Ser Ser Ser 
    1310                 1315                 1320             


Tyr Leu  Ala Ser Ser Gln Glu  Glu Asp Ser Gly Gln  Ser Leu Pro 
    1325                 1330                 1335             


Thr Ala  His Val Arg Pro Ser  His Pro Leu Lys Ser  Phe Ala Val 
    1340                 1345                 1350             


Pro Ala  Ile Pro Pro Pro Gly  Pro Pro Thr Tyr Asp  Pro Ala Leu 
    1355                 1360                 1365             


Pro Ser  Thr Pro Leu Leu Ser  Gln Gln Ala Leu Asn  His His Ile 
    1370                 1375                 1380             


His Ser  Val Lys Thr Ala Ser  Ile Gly Thr Leu Gly  Arg Ser Arg 
    1385                 1390                 1395             


Pro Pro  Met Pro Val Val Val  Pro Ser Ala Pro Glu  Val Gln Glu 
    1400                 1405                 1410             


Thr Thr  Arg Met Leu Glu Asp  Ser Glu Ser Ser Tyr  Glu Pro Asp 
    1415                 1420                 1425             


Glu Leu  Thr Lys Glu Met Ala  His Leu Glu Gly Leu  Met Lys Asp 
    1430                 1435                 1440             


Leu Asn  Ala Ile Thr Thr Ala  
    1445                 1450 


