
                                SEQUENCE LISTING

<110> Burden, Steven J.
      Zhang, Wei
      Huijbers, Maartje
      Verschuuren, Johannes J.
      van der Maarel, Silvere M.

<120> Methods for Treating Muscle Specific
  Receptor Kinase Myasthenia Gravis
  

<130> 3413-1-001PCT

<140> PCT/US2014/055618    
<141> 2014-09-15  

<150> 61/877,557          
<151> 2013-09-13  

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2666
<212> DNA
<213> Homo sapiens


<400> 1
tgcgttgtcc agaaggaact tcgtcctgcg tgagcctgga ttaatcatga gagagctcgt 60
caacattcca ctggtacata ttcttactct ggttgccttc agcggaactg agaaacttcc 120
aaaagctcct gtcatcacca ctcctcttga aacagtggat gccttagttg aagaagtggc 180
tactttcatg tgtgcagtgg aatcctaccc ccagcctgag atttcctgga ctagaaataa 240
aattctcatt aaactctttg acacccggta cagcatccgg gagaatgggc agctcctcac 300
catcctgagt gtggaagaca gtgatgatgg catttactgc tgcacggcca acaatggtgt 360
gggaggagct gtggagagtt gtggagccct gcaagtgaag atgaaaccta aaataactcg 420
ccctcccata aatgtgaaaa taatagaggg attaaaagca gtcctaccat gtactacaat 480
gggtaatccc aaaccatcag tgtcttggat aaagggagac agccctctca gggaaaattc 540
ccgaattgca gttcttgaat ctgggagctt gaggattcat aacgtacaaa aggaagatgc 600
aggacagtat cgatgtgtgg caaaaaacag cctcgggaca gcatattcca aagtggtgaa 660
gctggaagtt gaggtttttg ccaggatcct gcgggctcct gaatcccaca atgtcacctt 720
tggctccttt gtgaccctgc actgtacagc aacaggcatt cctgtcccca ccatcacctg 780
gattgaaaac ggaaatgctg tttcttctgg gtccattcaa gagagtgtga aagaccgagt 840
gattgactca agactgcagc tgtttatcac caagccagga ctctacacat gcatagctac 900
caataagcat ggggagaagt tcagtactgc caaggctgca gccaccatca gcatagcaga 960
atggagtaaa ccacagaaag ataacaaagg ctactgcgcc cagtacagag gggaggtgtg 1020
taatgcagtc ctggcaaaag atgctcttgt ttttctcaac acctcctatg cggaccctga 1080
ggaggcccaa gagctactgg tccacacggc ctggaatgaa ctgaaagtag tgagcccagt 1140
ctgccggcca gctgctgagg ctttgttgtg taaccacatc ttccaggagt gcagtcctgg 1200
agtagtgcct actcctattc ccatttgcag agagtactgc ttggcagtaa aggagctctt 1260
ctgcgcaaaa gaatggctgg taatggaaga gaagacccac agaggactct acagatccga 1320
gatgcatttg ctgtccgtgc cagaatgcag caagcttccc agcatgcatt gggaccccac 1380
ggcctgtgcc agactgccac atctagatta taacaaagaa aacctaaaaa cattcccacc 1440
aatgacgtcc tcaaagccaa gtgtggacat tccaaatctg ccttcctcct cctcttcttc 1500
cttctctgtc tcacctacat actccatgac tgtaataatc tccatcatgt ccagctttgc 1560
aatatttgtg cttcttacca taactactct ctattgctgc cgaagaagaa aacaatggaa 1620
aaataagaaa agagaatcag cagcagtaac cctcaccaca ctgccttctg agctcttact 1680
agatagactt catcccaacc ccatgtacca gaggatgccg ctccttctga accccaaatt 1740
gctcagcctg gagtatccaa ggaataacat tgaatatgtg agagacatcg gagagggagc 1800
gtttggaagg gtgtttcaag caagggcacc aggcttactt ccctatgaac ctttcactat 1860
ggtggcagta aagatgctca aagaagaagc ctcggcagat atgcaagcgg actttcagag 1920
ggaggcagcc ctcatggcag aatttgacaa ccctaacatt gtgaagctat taggagtgtg 1980
tgctgtcggg aagccaatgt gcctgctctt tgaatacatg gcctatggtg acctcaatga 2040
gttcctccgc agcatgtccc ctcacaccgt gtgcagcctc agtcacagtg acttgtctat 2100
gagggctcag gtctccagcc ctgggccccc acccctctcc tgtgctgagc agctttgcat 2160
tgccaggcag gtggcagctg gcatggctta cctctcagaa cgtaagtttg ttcaccgaga 2220
tttagccacc aggaactgcc tggtgggcga gaacatggtg gtgaaaattg ccgactttgg 2280
cctctccagg aacatctact cagcagacta ctacaaagct aatgaaaacg acgctatccc 2340
tatccgttgg atgccaccag agtccatttt ttataaccgc tacactacag agtctgatgt 2400
gtgggcctat ggcgtggtcc tctgggagat cttctcctat ggcctgcagc cctactatgg 2460
gatggcccat gaggaggtca tttactacgt gcgagatggc aacatcctct cctgccctga 2520
gaactgcccc gtggagctgt acaatctcat gcgtctatgt tggagcaagc tgcctgcaga 2580
cagacccagt ttcaccagta ttcaccgaat tctggaacgc atgtgtgaga gggcagaggg 2640
aactgtgagt gtctaaggtt gaagac                                      2666


<210> 2
<211> 869
<212> PRT
<213> Homo sapiens


<400> 2
Met Arg Glu Leu Val Asn Ile Pro Leu Val His Ile Leu Thr Leu Val
 1               5                  10                  15      
Ala Phe Ser Gly Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr
            20                  25                  30          
Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met
        35                  40                  45              
Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn
    50                  55                  60                  
Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn
65                  70                  75                  80  
Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile
                85                  90                  95      
Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys
            100                 105                 110         
Gly Ala Leu Gln Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile
        115                 120                 125             
Asn Val Lys Ile Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr
    130                 135                 140                 
Met Gly Asn Pro Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro
145                 150                 155                 160 
Leu Arg Glu Asn Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg
                165                 170                 175     
Ile His Asn Val Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala
            180                 185                 190         
Lys Asn Ser Leu Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val
        195                 200                 205             
Glu Val Phe Ala Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr
    210                 215                 220                 
Phe Gly Ser Phe Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val
225                 230                 235                 240 
Pro Thr Ile Thr Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser
                245                 250                 255     
Ile Gln Glu Ser Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu
            260                 265                 270         
Phe Ile Thr Lys Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His
        275                 280                 285             
Gly Glu Lys Phe Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala
    290                 295                 300                 
Glu Trp Ser Lys Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr
305                 310                 315                 320 
Arg Gly Glu Val Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe
                325                 330                 335     
Leu Asn Thr Ser Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val
            340                 345                 350         
His Thr Ala Trp Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro
        355                 360                 365             
Ala Ala Glu Ala Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro
    370                 375                 380                 
Gly Val Val Pro Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala
385                 390                 395                 400 
Val Lys Glu Leu Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys
                405                 410                 415     
Thr His Arg Gly Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro
            420                 425                 430         
Glu Cys Ser Lys Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala
        435                 440                 445             
Arg Leu Pro His Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro
    450                 455                 460                 
Pro Met Thr Ser Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser
465                 470                 475                 480 
Ser Ser Ser Ser Ser Phe Ser Val Ser Pro Thr Tyr Ser Met Thr Val
                485                 490                 495     
Ile Ile Ser Ile Met Ser Ser Phe Ala Ile Phe Val Leu Leu Thr Ile
            500                 505                 510         
Thr Thr Leu Tyr Cys Cys Arg Arg Arg Lys Gln Trp Lys Asn Lys Lys
        515                 520                 525             
Arg Glu Ser Ala Ala Val Thr Leu Thr Thr Leu Pro Ser Glu Leu Leu
    530                 535                 540                 
Leu Asp Arg Leu His Pro Asn Pro Met Tyr Gln Arg Met Pro Leu Leu
545                 550                 555                 560 
Leu Asn Pro Lys Leu Leu Ser Leu Glu Tyr Pro Arg Asn Asn Ile Glu
                565                 570                 575     
Tyr Val Arg Asp Ile Gly Glu Gly Ala Phe Gly Arg Val Phe Gln Ala
            580                 585                 590         
Arg Ala Pro Gly Leu Leu Pro Tyr Glu Pro Phe Thr Met Val Ala Val
        595                 600                 605             
Lys Met Leu Lys Glu Glu Ala Ser Ala Asp Met Gln Ala Asp Phe Gln
    610                 615                 620                 
Arg Glu Ala Ala Leu Met Ala Glu Phe Asp Asn Pro Asn Ile Val Lys
625                 630                 635                 640 
Leu Leu Gly Val Cys Ala Val Gly Lys Pro Met Cys Leu Leu Phe Glu
                645                 650                 655     
Tyr Met Ala Tyr Gly Asp Leu Asn Glu Phe Leu Arg Ser Met Ser Pro
            660                 665                 670         
His Thr Val Cys Ser Leu Ser His Ser Asp Leu Ser Met Arg Ala Gln
        675                 680                 685             
Val Ser Ser Pro Gly Pro Pro Pro Leu Ser Cys Ala Glu Gln Leu Cys
    690                 695                 700                 
Ile Ala Arg Gln Val Ala Ala Gly Met Ala Tyr Leu Ser Glu Arg Lys
705                 710                 715                 720 
Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn
                725                 730                 735     
Met Val Val Lys Ile Ala Asp Phe Gly Leu Ser Arg Asn Ile Tyr Ser
            740                 745                 750         
Ala Asp Tyr Tyr Lys Ala Asn Glu Asn Asp Ala Ile Pro Ile Arg Trp
        755                 760                 765             
Met Pro Pro Glu Ser Ile Phe Tyr Asn Arg Tyr Thr Thr Glu Ser Asp
    770                 775                 780                 
Val Trp Ala Tyr Gly Val Val Leu Trp Glu Ile Phe Ser Tyr Gly Leu
785                 790                 795                 800 
Gln Pro Tyr Tyr Gly Met Ala His Glu Glu Val Ile Tyr Tyr Val Arg
                805                 810                 815     
Asp Gly Asn Ile Leu Ser Cys Pro Glu Asn Cys Pro Val Glu Leu Tyr
            820                 825                 830         
Asn Leu Met Arg Leu Cys Trp Ser Lys Leu Pro Ala Asp Arg Pro Ser
        835                 840                 845             
Phe Thr Ser Ile His Arg Ile Leu Glu Arg Met Cys Glu Arg Ala Glu
    850                 855                 860                 
Gly Thr Val Ser Val
865                 


<210> 3
<211> 2772
<212> DNA
<213> Homo sapiens


<400> 3
gtggagctgc tgacacaaac agtcattagc agacaaccct tttgcaacaa agtatgcttt 60
aaaatgtaaa ctgtggagcc attttccttg cgttgtccag aaggaacttc gtcctgcgtg 120
agcctggatt aatcatgaga gagctcgtca acattccact ggtacatatt cttactctgg 180
ttgccttcag cggaactgag aaacttccaa aagctcctgt catcaccact cctcttgaaa 240
cagtggatgc cttagttgaa gaagtggcta ctttcatgtg tgcagtggaa tcctaccccc 300
agcctgagat ttcctggact agaaataaaa ttctcattaa actctttgac acccggtaca 360
gcatccggga gaatgggcag ctcctcacca tcctgagtgt ggaagacagt gatgatggca 420
tttactgctg cacggccaac aatggtgtgg gaggagctgt ggagagttgt ggagccctgc 480
aagtgaagat gaaacctaaa ataactcgtc ctcccataaa tgtgaaaata atagagggat 540
taaaagcagt cctaccatgt actacaatgg gtaatcccaa accatcagtg tcttggataa 600
agggagacag ccctctcagg gaaaattccc gaattgcagt tcttgaatct gggagcttga 660
ggattcataa cgtacaaaag gaagatgcag gacagtatcg atgtgtggca aaaaacagcc 720
tcgggacagc atattccaaa gtggtgaagc tggaagttga ggtttttgcc aggatcctgc 780
gggctcctga atcccacaat gtcacctttg gctcctttgt gaccctgcac tgtacagcaa 840
caggcattcc tgtccccacc atcacctgga ttgaaaacgg aaatgctgtt tcttctgggt 900
ccattcaaga gagtgtgaaa gaccgagtga ttgactcaag actgcagctg tttatcacca 960
agccaggact ctacacatgc atagctacca ataagcatgg ggagaagttc agtactgcca 1020
aggctgcagc caccatcagc atagcagaaa tgttgttcat ttcttctttc agtaaaccac 1080
agaaagataa caaaggctac tgcgcccagt acagagggga ggtgtgtaat gcagtcctgg 1140
caaaagatgc tcttgttttt ctcaacacct cctatgcgga ccctgaggag gcccaagagc 1200
tactggtcca cacggcctgg aatgaactga aagtagtgag cccagtctgc cggccagctg 1260
ctgaggcttt gttgtgtaac cacatcttcc aggagtgcag tcctggagta gtgcctactc 1320
ctattcccat ttgcagagag tactgcttgg cagtaaagga gctcttctgc gcaaaagaat 1380
ggctggtaat ggaagagaag acccacagag gactctacag atccgagatg catttgctgt 1440
ccgtgccaga atgcagcaag cttcccagca tgcattggga ccccacggcc tgtgccagac 1500
tgccacatct agattataac aaagaaaacc taaaaacatt cccaccaatg acgtcctcaa 1560
agccaagtgt ggacattcca aatctgcctt cctcctcctc ttcttccttc tctgtctcac 1620
ctacatactc catgactgta ataatctcca tcatgtccag ctttgcaata tttgtgcttc 1680
ttaccataac tactctctat tgctgccgaa gaagaaaaca atggaaaaat aagaaaagag 1740
aatcagcagc agtaaccctc accacactgc cttctgagct cttactagat agacttcatc 1800
ccaaccccat gtaccagagg atgccgctcc ttctgaaccc caaattgctc agcctggagt 1860
atccaaggaa taacattgaa tatgtgagag acatcggaga gggagcgttt ggaagggtgt 1920
ttcaagcaag ggcaccaggc ttacttccct atgaaccttt cactatggtg gcagtaaaga 1980
tgctcaaaga agaagcctcg gcagatatgc aagcggactt tcagagggag gcagccctca 2040
tggcagaatt tgacaaccct aacattgtga agctattagg agtgtgtgct gtcgggaagc 2100
caatgtgcct gctctttgaa tacatggcct atggtgacct caatgagttc ctccgcagca 2160
tgtcccctca caccgtgtgc agcctcagtc acagtgactt gtctatgagg gctcaggtct 2220
ccagccctgg gcccccaccc ctctcctgtg ctgagcagct ttgcattgcc aggcaggtgg 2280
cagctggcat ggcttacctc tcagaacgta agtttgttca ccgagattta gccaccagga 2340
actgcctggt gggcgagaac atggtggtga aaattgccga ctttggcctc tccaggaaca 2400
tctactcagc agactactac aaagctaatg aaaacgacgc tatccctatc cgttggatgc 2460
caccagagtc cattttttat aaccgctaca ctacagagtc tgatgtgtgg gcctatggcg 2520
tggtcctctg ggagatcttc tcctatggcc tgcagcccta ctatgggatg gcccatgagg 2580
aggtcattta ctacgtgcga gatggcaaca tcctctcctg ccctgagaac tgccccgtgg 2640
agctgtacaa tctcatgcgt ctatgttgga gcaagctgcc tgcagacaga cccagtttca 2700
ccagtattca ccgaattctg gaacgcatgt gtgagagggc agagggaact gtgagtgtct 2760
aaggttgaag ac                                                     2772


<210> 4
<211> 923
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature
<222> (9)...(9)
<223> Xaa is a translational stop

<220> 
<221> misc_feature
<222> (20)...(20)
<223> Xaa is a translational stop

<220> 
<221> misc_feature
<222> (920)...(920)
<223> Xaa is a translational stop

<220> 
<221> misc_feature
<222> (922)...(922)
<223> Xaa is a translational stop

<400> 4
Gly Ala Ala Asp Thr Asn Ser His Xaa Gln Thr Thr Leu Leu Gln Gln
 1               5                  10                  15      
Ser Met Leu Xaa Asn Val Asn Cys Gly Ala Ile Phe Leu Ala Leu Ser
            20                  25                  30          
Arg Arg Asn Phe Val Leu Arg Glu Pro Gly Leu Ile Met Arg Glu Leu
        35                  40                  45              
Val Asn Ile Pro Leu Val His Ile Leu Thr Leu Val Ala Phe Ser Gly
    50                  55                  60                  
Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr Pro Leu Glu Thr
65                  70                  75                  80  
Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met Cys Ala Val Glu
                85                  90                  95      
Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn Lys Ile Leu Ile
            100                 105                 110         
Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn Gly Gln Leu Leu
        115                 120                 125             
Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile Tyr Cys Cys Thr
    130                 135                 140                 
Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys Gly Ala Leu Gln
145                 150                 155                 160 
Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile Asn Val Lys Ile
                165                 170                 175     
Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr Met Gly Asn Pro
            180                 185                 190         
Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro Leu Arg Glu Asn
        195                 200                 205             
Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg Ile His Asn Val
    210                 215                 220                 
Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala Lys Asn Ser Leu
225                 230                 235                 240 
Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val Glu Val Phe Ala
                245                 250                 255     
Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr Phe Gly Ser Phe
            260                 265                 270         
Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val Pro Thr Ile Thr
        275                 280                 285             
Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser Ile Gln Glu Ser
    290                 295                 300                 
Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu Phe Ile Thr Lys
305                 310                 315                 320 
Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His Gly Glu Lys Phe
                325                 330                 335     
Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala Glu Met Leu Phe
            340                 345                 350         
Ile Ser Ser Phe Ser Lys Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala
        355                 360                 365             
Gln Tyr Arg Gly Glu Val Cys Asn Ala Val Leu Ala Lys Asp Ala Leu
    370                 375                 380                 
Val Phe Leu Asn Thr Ser Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu
385                 390                 395                 400 
Leu Val His Thr Ala Trp Asn Glu Leu Lys Val Val Ser Pro Val Cys
                405                 410                 415     
Arg Pro Ala Ala Glu Ala Leu Leu Cys Asn His Ile Phe Gln Glu Cys
            420                 425                 430         
Ser Pro Gly Val Val Pro Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys
        435                 440                 445             
Leu Ala Val Lys Glu Leu Phe Cys Ala Lys Glu Trp Leu Val Met Glu
    450                 455                 460                 
Glu Lys Thr His Arg Gly Leu Tyr Arg Ser Glu Met His Leu Leu Ser
465                 470                 475                 480 
Val Pro Glu Cys Ser Lys Leu Pro Ser Met His Trp Asp Pro Thr Ala
                485                 490                 495     
Cys Ala Arg Leu Pro His Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr
            500                 505                 510         
Phe Pro Pro Met Thr Ser Ser Lys Pro Ser Val Asp Ile Pro Asn Leu
        515                 520                 525             
Pro Ser Ser Ser Ser Ser Ser Phe Ser Val Ser Pro Thr Tyr Ser Met
    530                 535                 540                 
Thr Val Ile Ile Ser Ile Met Ser Ser Phe Ala Ile Phe Val Leu Leu
545                 550                 555                 560 
Thr Ile Thr Thr Leu Tyr Cys Cys Arg Arg Arg Lys Gln Trp Lys Asn
                565                 570                 575     
Lys Lys Arg Glu Ser Ala Ala Val Thr Leu Thr Thr Leu Pro Ser Glu
            580                 585                 590         
Leu Leu Leu Asp Arg Leu His Pro Asn Pro Met Tyr Gln Arg Met Pro
        595                 600                 605             
Leu Leu Leu Asn Pro Lys Leu Leu Ser Leu Glu Tyr Pro Arg Asn Asn
    610                 615                 620                 
Ile Glu Tyr Val Arg Asp Ile Gly Glu Gly Ala Phe Gly Arg Val Phe
625                 630                 635                 640 
Gln Ala Arg Ala Pro Gly Leu Leu Pro Tyr Glu Pro Phe Thr Met Val
                645                 650                 655     
Ala Val Lys Met Leu Lys Glu Glu Ala Ser Ala Asp Met Gln Ala Asp
            660                 665                 670         
Phe Gln Arg Glu Ala Ala Leu Met Ala Glu Phe Asp Asn Pro Asn Ile
        675                 680                 685             
Val Lys Leu Leu Gly Val Cys Ala Val Gly Lys Pro Met Cys Leu Leu
    690                 695                 700                 
Phe Glu Tyr Met Ala Tyr Gly Asp Leu Asn Glu Phe Leu Arg Ser Met
705                 710                 715                 720 
Ser Pro His Thr Val Cys Ser Leu Ser His Ser Asp Leu Ser Met Arg
                725                 730                 735     
Ala Gln Val Ser Ser Pro Gly Pro Pro Pro Leu Ser Cys Ala Glu Gln
            740                 745                 750         
Leu Cys Ile Ala Arg Gln Val Ala Ala Gly Met Ala Tyr Leu Ser Glu
        755                 760                 765             
Arg Lys Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly
    770                 775                 780                 
Glu Asn Met Val Val Lys Ile Ala Asp Phe Gly Leu Ser Arg Asn Ile
785                 790                 795                 800 
Tyr Ser Ala Asp Tyr Tyr Lys Ala Asn Glu Asn Asp Ala Ile Pro Ile
                805                 810                 815     
Arg Trp Met Pro Pro Glu Ser Ile Phe Tyr Asn Arg Tyr Thr Thr Glu
            820                 825                 830         
Ser Asp Val Trp Ala Tyr Gly Val Val Leu Trp Glu Ile Phe Ser Tyr
        835                 840                 845             
Gly Leu Gln Pro Tyr Tyr Gly Met Ala His Glu Glu Val Ile Tyr Tyr
    850                 855                 860                 
Val Arg Asp Gly Asn Ile Leu Ser Cys Pro Glu Asn Cys Pro Val Glu
865                 870                 875                 880 
Leu Tyr Asn Leu Met Arg Leu Cys Trp Ser Lys Leu Pro Ala Asp Arg
                885                 890                 895     
Pro Ser Phe Thr Ser Ile His Arg Ile Leu Glu Arg Met Cys Glu Arg
            900                 905                 910         
Ala Glu Gly Thr Val Ser Val Xaa Gly Xaa Arg
        915                 920             


<210> 5
<211> 473
<212> PRT
<213> Homo sapiens


<400> 5
Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr Pro Leu Glu Thr
 1               5                  10                  15      
Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met Cys Ala Val Glu
            20                  25                  30          
Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn Lys Ile Leu Ile
        35                  40                  45              
Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn Gly Gln Leu Leu
    50                  55                  60                  
Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile Tyr Cys Cys Thr
65                  70                  75                  80  
Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys Gly Ala Leu Gln
                85                  90                  95      
Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile Asn Val Lys Ile
            100                 105                 110         
Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr Met Gly Asn Pro
        115                 120                 125             
Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro Leu Arg Glu Asn
    130                 135                 140                 
Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg Ile His Asn Val
145                 150                 155                 160 
Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala Lys Asn Ser Leu
                165                 170                 175     
Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val Glu Val Phe Ala
            180                 185                 190         
Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr Phe Gly Ser Phe
        195                 200                 205             
Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val Pro Thr Ile Thr
    210                 215                 220                 
Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser Ile Gln Glu Ser
225                 230                 235                 240 
Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu Phe Ile Thr Lys
                245                 250                 255     
Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His Gly Glu Lys Phe
            260                 265                 270         
Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala Glu Trp Ser Lys
        275                 280                 285             
Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr Arg Gly Glu Val
    290                 295                 300                 
Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe Leu Asn Thr Ser
305                 310                 315                 320 
Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val His Thr Ala Trp
                325                 330                 335     
Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro Ala Ala Glu Ala
            340                 345                 350         
Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro Gly Val Val Pro
        355                 360                 365             
Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala Val Lys Glu Leu
    370                 375                 380                 
Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys Thr His Arg Gly
385                 390                 395                 400 
Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro Glu Cys Ser Lys
                405                 410                 415     
Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala Arg Leu Pro His
            420                 425                 430         
Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro Pro Met Thr Ser
        435                 440                 445             
Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser Ser Ser Ser Ser
    450                 455                 460                 
Ser Phe Ser Val Ser Pro Thr Tyr Ser
465                 470             


<210> 6
<211> 420
<212> PRT
<213> Homo sapiens


<400> 6
Arg Tyr Ser Ile Arg Glu Asn Gly Gln Leu Leu Thr Ile Leu Ser Val
 1               5                  10                  15      
Glu Asp Ser Asp Asp Gly Ile Tyr Cys Cys Thr Ala Asn Asn Gly Val
            20                  25                  30          
Gly Gly Ala Val Glu Ser Cys Gly Ala Leu Gln Val Lys Met Lys Pro
        35                  40                  45              
Lys Ile Thr Arg Pro Pro Ile Asn Val Lys Ile Ile Glu Gly Leu Lys
    50                  55                  60                  
Ala Val Leu Pro Cys Thr Thr Met Gly Asn Pro Lys Pro Ser Val Ser
65                  70                  75                  80  
Trp Ile Lys Gly Asp Ser Pro Leu Arg Glu Asn Ser Arg Ile Ala Val
                85                  90                  95      
Leu Glu Ser Gly Ser Leu Arg Ile His Asn Val Gln Lys Glu Asp Ala
            100                 105                 110         
Gly Gln Tyr Arg Cys Val Ala Lys Asn Ser Leu Gly Thr Ala Tyr Ser
        115                 120                 125             
Lys Val Val Lys Leu Glu Val Glu Val Phe Ala Arg Ile Leu Arg Ala
    130                 135                 140                 
Pro Glu Ser His Asn Val Thr Phe Gly Ser Phe Val Thr Leu His Cys
145                 150                 155                 160 
Thr Ala Thr Gly Ile Pro Val Pro Thr Ile Thr Trp Ile Glu Asn Gly
                165                 170                 175     
Asn Ala Val Ser Ser Gly Ser Ile Gln Glu Ser Val Lys Asp Arg Val
            180                 185                 190         
Ile Asp Ser Arg Leu Gln Leu Phe Ile Thr Lys Pro Gly Leu Tyr Thr
        195                 200                 205             
Cys Ile Ala Thr Asn Lys His Gly Glu Lys Phe Ser Thr Ala Lys Ala
    210                 215                 220                 
Ala Ala Thr Ile Ser Ile Ala Glu Trp Ser Lys Pro Gln Lys Asp Asn
225                 230                 235                 240 
Lys Gly Tyr Cys Ala Gln Tyr Arg Gly Glu Val Cys Asn Ala Val Leu
                245                 250                 255     
Ala Lys Asp Ala Leu Val Phe Leu Asn Thr Ser Tyr Ala Asp Pro Glu
            260                 265                 270         
Glu Ala Gln Glu Leu Leu Val His Thr Ala Trp Asn Glu Leu Lys Val
        275                 280                 285             
Val Ser Pro Val Cys Arg Pro Ala Ala Glu Ala Leu Leu Cys Asn His
    290                 295                 300                 
Ile Phe Gln Glu Cys Ser Pro Gly Val Val Pro Thr Pro Ile Pro Ile
305                 310                 315                 320 
Cys Arg Glu Tyr Cys Leu Ala Val Lys Glu Leu Phe Cys Ala Lys Glu
                325                 330                 335     
Trp Leu Val Met Glu Glu Lys Thr His Arg Gly Leu Tyr Arg Ser Glu
            340                 345                 350         
Met His Leu Leu Ser Val Pro Glu Cys Ser Lys Leu Pro Ser Met His
        355                 360                 365             
Trp Asp Pro Thr Ala Cys Ala Arg Leu Pro His Leu Asp Tyr Asn Lys
    370                 375                 380                 
Glu Asn Leu Lys Thr Phe Pro Pro Met Thr Ser Ser Lys Pro Ser Val
385                 390                 395                 400 
Asp Ile Pro Asn Leu Pro Ser Ser Ser Ser Ser Ser Phe Ser Val Ser
                405                 410                 415     
Pro Thr Tyr Ser
            420 


<210> 7
<211> 281
<212> PRT
<213> Homo sapiens

<400> 7
Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr Phe Gly Ser Phe
 1               5                  10                  15      
Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val Pro Thr Ile Thr
            20                  25                  30          
Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser Ile Gln Glu Ser
        35                  40                  45              
Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu Phe Ile Thr Lys
    50                  55                  60                  
Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His Gly Glu Lys Phe
65                  70                  75                  80  
Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala Glu Trp Ser Lys
                85                  90                  95      
Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr Arg Gly Glu Val
            100                 105                 110         
Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe Leu Asn Thr Ser
        115                 120                 125             
Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val His Thr Ala Trp
    130                 135                 140                 
Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro Ala Ala Glu Ala
145                 150                 155                 160 
Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro Gly Val Val Pro
                165                 170                 175     
Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala Val Lys Glu Leu
            180                 185                 190         
Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys Thr His Arg Gly
        195                 200                 205             
Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro Glu Cys Ser Lys
    210                 215                 220                 
Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala Arg Leu Pro His
225                 230                 235                 240 
Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro Pro Met Thr Ser
                245                 250                 255     
Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser Ser Ser Ser Ser
            260                 265                 270         
Ser Phe Ser Val Ser Pro Thr Tyr Ser
        275                 280     


<210> 8
<211> 138
<212> PRT
<213> Homo sapiens

<400> 8
Asn Lys Gly Tyr Cys Ala Gln Tyr Arg Gly Glu Val Cys Asn Ala Val
 1               5                  10                  15      
Leu Ala Lys Asp Ala Leu Val Phe Leu Asn Thr Ser Tyr Ala Asp Pro
            20                  25                  30          
Glu Glu Ala Gln Glu Leu Leu Val His Thr Ala Trp Asn Glu Leu Lys
        35                  40                  45              
Val Val Ser Pro Val Cys Arg Pro Ala Ala Glu Ala Leu Leu Cys Asn
    50                  55                  60                  
His Ile Phe Gln Glu Cys Ser Pro Gly Val Val Pro Thr Pro Ile Pro
65                  70                  75                  80  
Ile Cys Arg Glu Tyr Cys Leu Ala Val Lys Glu Leu Phe Cys Ala Lys
                85                  90                  95      
Glu Trp Leu Val Met Glu Glu Lys Thr His Arg Gly Leu Tyr Arg Ser
            100                 105                 110         
Glu Met His Leu Leu Ser Val Pro Glu Cys Ser Lys Leu Pro Ser Met
        115                 120                 125             
His Trp Asp Pro Thr Ala Cys Ala Arg Leu
    130                 135             


<210> 9
<211> 105
<212> PRT
<213> Homo sapiens

<400> 9
Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr Pro Leu Glu Thr
 1               5                  10                  15      
Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met Cys Ala Val Glu
            20                  25                  30          
Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn Lys Ile Leu Ile
        35                  40                  45              
Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn Gly Gln Leu Leu
    50                  55                  60                  
Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile Tyr Cys Cys Thr
65                  70                  75                  80  
Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys Gly Ala Leu Gln
                85                  90                  95      
Val Lys Met Lys Pro Lys Ile Thr Arg
            100                 105 


<210> 10
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
gacctcgaga tgagagagct cgtcaacatt ccactg                           36


<210> 11
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 11
ctctcccgtc tcccttgaca ctcacagacc atggcgt                          37


<210> 12
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 12
gccttcagcg gaactgagaa acctaaaata actcgccctc cc                    42


<210> 13
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 13
agcgaattca tgagagagct cgtcaacatt c                                31


<210> 14
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 14
gagtggatgt atgaggtact gatctagacg t                                31


<210> 15
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 15
actttggcat gaccaggaac atctactcag ca                               32


<210> 16
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 16
agatgttcct ggtcatgcca aagtcggcaa ttttcac                          37


<210> 17
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 17
gacctcgaga tgagagagct cgtcaacatt ccactg                           36


<210> 18
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 18
gagagggcag agggaactgt gagtgtctgg taccgca                          37


<210> 19
<211> 90
<212> PRT
<213> Homo sapiens

<400> 19
Pro Val Ile Thr Thr Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu
 1               5                  10                  15      
Val Ala Thr Phe Met Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile
            20                  25                  30          
Ser Trp Thr Arg Asn Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr
        35                  40                  45              
Ser Ile Arg Glu Asn Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp
    50                  55                  60                  
Ser Asp Asp Gly Ile Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly
65                  70                  75                  80  
Ala Val Glu Ser Cys Gly Ala Leu Gln Val
                85                  90  

